- Email: [email protected]
743 Poster Experiences on microwave hyperthermia in clinical practice
Posters
Wednesday/Thursday, 18-19 September 2002 $223
for three things as a supplement to the treatment and care they are receiving: 1. Knowledge; 2. Action and 3. Support Those three things are the basis of our offer in form of: 1. Knowledge about diagnose, treatment and care 2. taking an active part in their course of treatment and care 3. being together with equal people while getting professional support, On the congress we will present our experience starting this project as welt as describing the aim, method and preliminary results.
many as in 75% of cases. References [1] Vrba, J., Lapes, M: Microwave applicators for medical use. CTU, t995 [2] Zamecnik, J., Volenec, K.: Hypertermia in Onkotogy. Avicenum, 1988 [3] Engin, K.: Hyperthermia in cancer treatment. Neoplasma, Nr. 5, 1994 This research has been supported by program: Transdisciplinary research in BME (J04/98:210000012). 744
Poster
Unscheduled interruptions in the radiation therapy of breast cancer
Low dose irradiation and short exposure suboptimal dose paclitaxel adversely modulate metastatic potential of squamous carcinoma cells
.M, Fradoca I , I. Bravo 1, R. Craveiro 1, M.J. Bento 2, I. Silva 1 1lnstituto Portugu~s de Oncofogia, Dep. de Radioterapia, PORTO, Portugal 21nstituto Portugu#s de Oncologia, Dep. de Epidemiotogia, PORTO, Portugal
J. LSvey I , K. Fazekas 2, A. Lad~ny~ 2, G. N~meth 1, J. Timdt2 1National Institute of Oncofogy, Dept. of Radiotherapy, Budapest, Hungary 2National Institute of Oncotogy, Dept. of Tumor Progression, Budapest, Hungary
Total treatment time represents a critical factor in quality control in radiotherapy. The work we are presenting here analysis the causes responsible for non-scheduled breaks in radiotherapy treatment of 150 women with breast cancer, treated in our department during 1999. For each patient we have analysed the number and duration of gaps and their causes: machine breakdown and equipment maintenance, public holiday, staff strike, absence of patient, and acute effects. Non-scheduled interruptions have affected 119 patients (79.3%) and the most common cause was acute effects associated with radiotherapy treatmont. Of the 52 patients that had their treatment interrupted because of this cause, 86,5% were being submitted to associated chemotherapy treatmerit; only 13,5 % of patients without associated chemotherapy had their treatment interrupted for the same cause (p<0,0001, Mann-Whitney test), It is important to notice that causes that could be resolved, namely, machine breakdown and equipment maintenance, public holidays and staff strike represent 56% of all treatment interruptions. A significant improvement in the reduction of these treatment gaps can therefore be obtained through the active motivation of staff and patients,
Introduction: Low dose irradiation and suboptimal drug concentrations may induce unexpected biological responses. Paclitaxel (PTX) is a widely used drug which have a range of antitumoral effects and regarded as a radiation sensitizer too. In our study we tested how "suboptimal" short exposure PTX modifies the biological effects of low dose irradiation on human epithelial carcinoma cell lines. Methods: Two Gy irradiation, 7 and 100 nM PTX treatment and their cornbinations were tested on squamous and transitional carcinoma cell lines A431, KB and ECV304. Cytoskeleton of interphase cells was investigated with immunocytochemistry and confocal scanning laser microscopy, viability and cl0nogenicity were assessed with MTT test and standard clonogenic assay. Effects on primary tumor growth and metastatic potential were tested in vivo using a liver metastasis model in SOlD mice. Results: Short exposure to irradiation of A431 cells induced bundling of microtubules, similar to PTX. Combined treatments suspended each other's effect independently of treatment combinations. Single- or combination treatments did not affect cell proliferation in vitro or in vivo (primary tumor xenografts). However, exposure to irradiation of A431 cells inhibited while t00 nM PTX stimulated the liver metastatic potential. Combination of 100 nM PTX with irradiation suspended the effect of 100 nM PTX and exhibited the highest antimetastatic activity. Conclusions: Short exposure to PTX and irradiation can interfere with each others effects on the cytoskeleton of tumor cells without significant modulation of proliferation and tumorigenicity. However, suboptimal PTX and irradiation adversely modulate the metastatic potential of human squamous carcinoma cell, A431.
742
Poster
MISCELLANEOUS 743 Poster E x p e r i e n c e s on microwave hyperthermia in c l i n i c a l p r a c t i c e
J. Kvech 1, L. Oppt2, J. Vrba2, J. Kubes I t lnstitute for Radiation Oncology ,University Hospital Butovka, Radiotherapy, Prague, Czech Republic
745
Poster
2Czech Technical University in Prague, , Faculty of Electrical Engineer-
Proton beam treatment at Hyogo ion beam medical center (HIBMC)
ing,, Prague, Czech Republic
~,, Murakami 1, K. Kagawa 1, Y. Hishikawa 1, M. Abe 1, S. Kamidono 2,
Introduction: Microwave hyperthermia is used as a therapeutic method in oncology for cancer treatment. Biological principle of this method is based on the reality, that the tumour cells are very sensitive on the temperature higher than 42°C, while the normal cells survive the increase temperature up to 45°C. It means, that the heating of the biological tissue in the tumour area on the temperature level 42°C to 45°C selectively destroys the tumour cells. This heating is usually realised by means of microwave energy, Treatment results: Since 1993 a clinical study at the working place of IRO in Prague was running. In this study 49 patients were evaluated, By 23 patients (47%) complete response (CR - complete elimination of the tumour) was achieved, partial response (PR - reduction of the tumour to less than half of original volume) was achieved by 14 patients (29%), with no response (NR - no or small reduction of the tumour) was 12 patients (24%). Successful treatment was so achieved by 76% of the patients. For the better view are the achieved results shown also in a tabular form. Table
IV. Tsubota 3, N. Nakao 4, K. Yoshino5 lHyogo Ion Beam Medical Center, Radiology, Hyogo, Japan
Complete response Partial response Successful treatment No response
(CR) (PR) (CR+PR) (NR)
23 patients 14 patients 37 patients 12 patients
47% 29% 76% 24%
The effect of hyperthermia treatment very well confirm also two series of pictures. Conclusion: Hyperthermia, especially superficial and regional, is very significant method for the cancer palliative therapy. This treatment method, especially in combination with radiotherapy, achieves successful results as
2Kobe University Graduate School of Medicine, Urology, Hyogo, Japan 3Hyogo Medical Center for Adults, Thoracic Surgery; Hyogo, Japan 4Hyogo College of Medicine, Radiology, Hyogo, Japan 5Osaka Medical Center for Cancer and Cardiovascular Diseases, Otolaryngotogy, Osaka, Japan Purpose: To confirm the acute toxicity, tumor response and stability of the machine which provides proton beams in the HIBMC. Material and methods: The HIBMC, opened in April 2001, has predominant features of (1) generating two ion beams including proton (70-230MeV/u) and carbon (70-320MeV/u), (2) delivering beams in 5 treatment units (2 gantry, 1 horizontal & vertical, t horizontal and 1 oblique fixed beam port), and (3) having a hospital (4,500m z) as an annex to a accelerator facility (12,000mZ). We started proton radiotherapy as a clinical study based on the Good Clinical Practices regulated by the Minister for Health, Labour and Welfare. The relative biological effectiveness of proton beams was estimated as 1.1 by precltnical investigations. Thirty patients with histological proven cancer originated in head & neck, lung, liver, or prostate cancer were treated. Eligibility criteria of the UICC TNM staging system were TIT2NOMO in both lung and prostate cancer. However, in H & N and liver cancer, it did not care about TN factors instead of a requirement about tumor size within 12 cm in diameter. There were 26 males and 4 females. All patients had an ECOG performance status of
Wednesday/Thursday, 18-19 September 2002 $223
for three things as a supplement to the treatment and care they are receiving: 1. Knowledge; 2. Action and 3. Support Those three things are the basis of our offer in form of: 1. Knowledge about diagnose, treatment and care 2. taking an active part in their course of treatment and care 3. being together with equal people while getting professional support, On the congress we will present our experience starting this project as welt as describing the aim, method and preliminary results.
many as in 75% of cases. References [1] Vrba, J., Lapes, M: Microwave applicators for medical use. CTU, t995 [2] Zamecnik, J., Volenec, K.: Hypertermia in Onkotogy. Avicenum, 1988 [3] Engin, K.: Hyperthermia in cancer treatment. Neoplasma, Nr. 5, 1994 This research has been supported by program: Transdisciplinary research in BME (J04/98:210000012). 744
Poster
Unscheduled interruptions in the radiation therapy of breast cancer
Low dose irradiation and short exposure suboptimal dose paclitaxel adversely modulate metastatic potential of squamous carcinoma cells
.M, Fradoca I , I. Bravo 1, R. Craveiro 1, M.J. Bento 2, I. Silva 1 1lnstituto Portugu~s de Oncofogia, Dep. de Radioterapia, PORTO, Portugal 21nstituto Portugu#s de Oncologia, Dep. de Epidemiotogia, PORTO, Portugal
J. LSvey I , K. Fazekas 2, A. Lad~ny~ 2, G. N~meth 1, J. Timdt2 1National Institute of Oncofogy, Dept. of Radiotherapy, Budapest, Hungary 2National Institute of Oncotogy, Dept. of Tumor Progression, Budapest, Hungary
Total treatment time represents a critical factor in quality control in radiotherapy. The work we are presenting here analysis the causes responsible for non-scheduled breaks in radiotherapy treatment of 150 women with breast cancer, treated in our department during 1999. For each patient we have analysed the number and duration of gaps and their causes: machine breakdown and equipment maintenance, public holiday, staff strike, absence of patient, and acute effects. Non-scheduled interruptions have affected 119 patients (79.3%) and the most common cause was acute effects associated with radiotherapy treatmont. Of the 52 patients that had their treatment interrupted because of this cause, 86,5% were being submitted to associated chemotherapy treatmerit; only 13,5 % of patients without associated chemotherapy had their treatment interrupted for the same cause (p<0,0001, Mann-Whitney test), It is important to notice that causes that could be resolved, namely, machine breakdown and equipment maintenance, public holidays and staff strike represent 56% of all treatment interruptions. A significant improvement in the reduction of these treatment gaps can therefore be obtained through the active motivation of staff and patients,
Introduction: Low dose irradiation and suboptimal drug concentrations may induce unexpected biological responses. Paclitaxel (PTX) is a widely used drug which have a range of antitumoral effects and regarded as a radiation sensitizer too. In our study we tested how "suboptimal" short exposure PTX modifies the biological effects of low dose irradiation on human epithelial carcinoma cell lines. Methods: Two Gy irradiation, 7 and 100 nM PTX treatment and their cornbinations were tested on squamous and transitional carcinoma cell lines A431, KB and ECV304. Cytoskeleton of interphase cells was investigated with immunocytochemistry and confocal scanning laser microscopy, viability and cl0nogenicity were assessed with MTT test and standard clonogenic assay. Effects on primary tumor growth and metastatic potential were tested in vivo using a liver metastasis model in SOlD mice. Results: Short exposure to irradiation of A431 cells induced bundling of microtubules, similar to PTX. Combined treatments suspended each other's effect independently of treatment combinations. Single- or combination treatments did not affect cell proliferation in vitro or in vivo (primary tumor xenografts). However, exposure to irradiation of A431 cells inhibited while t00 nM PTX stimulated the liver metastatic potential. Combination of 100 nM PTX with irradiation suspended the effect of 100 nM PTX and exhibited the highest antimetastatic activity. Conclusions: Short exposure to PTX and irradiation can interfere with each others effects on the cytoskeleton of tumor cells without significant modulation of proliferation and tumorigenicity. However, suboptimal PTX and irradiation adversely modulate the metastatic potential of human squamous carcinoma cell, A431.
742
Poster
MISCELLANEOUS 743 Poster E x p e r i e n c e s on microwave hyperthermia in c l i n i c a l p r a c t i c e
J. Kvech 1, L. Oppt2, J. Vrba2, J. Kubes I t lnstitute for Radiation Oncology ,University Hospital Butovka, Radiotherapy, Prague, Czech Republic
745
Poster
2Czech Technical University in Prague, , Faculty of Electrical Engineer-
Proton beam treatment at Hyogo ion beam medical center (HIBMC)
ing,, Prague, Czech Republic
~,, Murakami 1, K. Kagawa 1, Y. Hishikawa 1, M. Abe 1, S. Kamidono 2,
Introduction: Microwave hyperthermia is used as a therapeutic method in oncology for cancer treatment. Biological principle of this method is based on the reality, that the tumour cells are very sensitive on the temperature higher than 42°C, while the normal cells survive the increase temperature up to 45°C. It means, that the heating of the biological tissue in the tumour area on the temperature level 42°C to 45°C selectively destroys the tumour cells. This heating is usually realised by means of microwave energy, Treatment results: Since 1993 a clinical study at the working place of IRO in Prague was running. In this study 49 patients were evaluated, By 23 patients (47%) complete response (CR - complete elimination of the tumour) was achieved, partial response (PR - reduction of the tumour to less than half of original volume) was achieved by 14 patients (29%), with no response (NR - no or small reduction of the tumour) was 12 patients (24%). Successful treatment was so achieved by 76% of the patients. For the better view are the achieved results shown also in a tabular form. Table
IV. Tsubota 3, N. Nakao 4, K. Yoshino5 lHyogo Ion Beam Medical Center, Radiology, Hyogo, Japan
Complete response Partial response Successful treatment No response
(CR) (PR) (CR+PR) (NR)
23 patients 14 patients 37 patients 12 patients
47% 29% 76% 24%
The effect of hyperthermia treatment very well confirm also two series of pictures. Conclusion: Hyperthermia, especially superficial and regional, is very significant method for the cancer palliative therapy. This treatment method, especially in combination with radiotherapy, achieves successful results as
2Kobe University Graduate School of Medicine, Urology, Hyogo, Japan 3Hyogo Medical Center for Adults, Thoracic Surgery; Hyogo, Japan 4Hyogo College of Medicine, Radiology, Hyogo, Japan 5Osaka Medical Center for Cancer and Cardiovascular Diseases, Otolaryngotogy, Osaka, Japan Purpose: To confirm the acute toxicity, tumor response and stability of the machine which provides proton beams in the HIBMC. Material and methods: The HIBMC, opened in April 2001, has predominant features of (1) generating two ion beams including proton (70-230MeV/u) and carbon (70-320MeV/u), (2) delivering beams in 5 treatment units (2 gantry, 1 horizontal & vertical, t horizontal and 1 oblique fixed beam port), and (3) having a hospital (4,500m z) as an annex to a accelerator facility (12,000mZ). We started proton radiotherapy as a clinical study based on the Good Clinical Practices regulated by the Minister for Health, Labour and Welfare. The relative biological effectiveness of proton beams was estimated as 1.1 by precltnical investigations. Thirty patients with histological proven cancer originated in head & neck, lung, liver, or prostate cancer were treated. Eligibility criteria of the UICC TNM staging system were TIT2NOMO in both lung and prostate cancer. However, in H & N and liver cancer, it did not care about TN factors instead of a requirement about tumor size within 12 cm in diameter. There were 26 males and 4 females. All patients had an ECOG performance status of