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8 Genetic mapping of a psoriasis gene in a large Quebec kindred
Abstracts JSIDjCSID
84
Joint Meeting
8 GENETIC MAPPING OF A PSORIASIS GENE IN A LARGE GUEBEC KINDRED. M.11.3Marasse3.8.,2.3Rausanau3.Se,vice da dermalcbgie, Hapita de I'Enfant-JBsus. 2Servke de dermatclcgie, Centre Hcmitalie, Universilaire de Ou&ec- Pav. St-Franc&-d'Assire. 3Uni18 de Racherche an GBn&ique Humaine a1 MoIBculaire. cent,0 de Rechercha de blOpItal St-F,anwiad'Aasise, Ouebec. Canada The etbbgk baaia of psoriasis vul~s,ls remains unknown allough HLA aaac.ci~llc,Ia have baen reported and genelk linkage was established lo, a pscriasis gene on 17q. Pscriasis is beleived 10 have a genetic component aspecIally the early 0nseI form. We have MenliHed a very large pscrlasis vu!ga,is type I five-generation family with a mean age clcnse1 of 20 years old and a transmission paaern compatible with an aukxcmal dcminanlgene with high penetrance. We have sampled and examined almost all living members of the family and collected 45ooNAsem*. After having
etiuded
the HLA region
a8 well as the 179 repbn
of the gencme
as the candMa1e ragions lo, the psoriasis gene in lhis family, we have con&dad that there vaa genetic hetetcgeneily in psoriasis and initiated a ~encrne-wide scan lo, genetic linkage with a panel cl314 Genethcn genetic ma&en ccverlng the whole human Qencme. Al tha presanl lime, wa have exdudDd80#cf~eQenomeanda,elinlshingthe scan. This work will lead lc the idendfkalicn of a new gene involved in psoriasis and will pmvide funhe, insight cn the elicbgical processes involved in Ihis lrequentdisepse.
9 ADULT T CELL LEUKEMIA DERIVED FACTOR IS INVOLVED IN ULTRAVIOLET B INDUCED MELANOGENES1-S BY UPREGULATING MSH RECEPTOR BINDING ACT,“,TY Ycka Funasaka,Ak,koOhash,. Mchkc NagaMma,Ashok K Chakraborty, Kobe Uw Masata Ueda, Hsdeya Ando. Masmmu Ich~hash~ Dept of Dermalology SChDd Of Meblclne. Kobe Japan Ultrav~olel B , UVB , IS known lo anduce act,ve oxygen spec,es I AOS , I” the ok,” The one Sklrl. howe”er. cO”n,eraclSAOS by bCfh SmCked arm newly produced anfloxldanls 0, such a”llox,dan,s Ad”,, Tel, Le”kem,a-Derived Facto, l ADF, ‘human hamoloaue Of
12 MELANOCYTIC NEVI IN SUN-PROTECTED CENTRAL ALBERTA CANADIAN
HUTTERITE
- CHILDREN _...-- .-..
T. Y. Kwan and T. Enta University of Calgary Total body melanccytic nevi (MN) were counted on Hutterite children living in Central Alberta, Canada. Hutterite children wear traditional clothes that provide continuous outdoor coverage to all parts of the body except the face and hands. A total of 332 children, aged 5 to 15, from 23 Hutterite colonies were examined. Of these children, 178 were male and 154 were famale. Nevi with diameters equal to or greater than 2 lllpl were counted on all body Surface areas except the scalp, buttocks, pubic region, and genitalia. In post pubescent females. breast area was not examined. Mean total body nevi in Hutterite children ranging in age fmm 5 to 15 was 2.34 and mean nevi increased with age at a rate of 0.5 nevi per yew. Both the mean number of nevi and the yearly rate of increase were lower than previously reported for children in similar age range. In addition, a sex difference in location of nevi was observed. Females had higher mean nevi on extremities than msles and males had a higher mean m on the torso than did females. Increases in nevi with age were primarily a function of increases on the extremities for females and on the torso for ales. The cccur~ence of this pattern in Hutterite children questions the explanation that this sex difference is due to differential exposure to sunlight between the sexes. Overall, the results were consistent withthe hypothesis that exposure to Sunlight produces greater numbers
of
nevi
in
Caucasians.
84
Joint Meeting
8 GENETIC MAPPING OF A PSORIASIS GENE IN A LARGE GUEBEC KINDRED. M.11.3Marasse3.8.,2.3Rausanau3.Se,vice da dermalcbgie, Hapita de I'Enfant-JBsus. 2Servke de dermatclcgie, Centre Hcmitalie, Universilaire de Ou&ec- Pav. St-Franc&-d'Assire. 3Uni18 de Racherche an GBn&ique Humaine a1 MoIBculaire. cent,0 de Rechercha de blOpItal St-F,anwiad'Aasise, Ouebec. Canada The etbbgk baaia of psoriasis vul~s,ls remains unknown allough HLA aaac.ci~llc,Ia have baen reported and genelk linkage was established lo, a pscriasis gene on 17q. Pscriasis is beleived 10 have a genetic component aspecIally the early 0nseI form. We have MenliHed a very large pscrlasis vu!ga,is type I five-generation family with a mean age clcnse1 of 20 years old and a transmission paaern compatible with an aukxcmal dcminanlgene with high penetrance. We have sampled and examined almost all living members of the family and collected 45ooNAsem*. After having
etiuded
the HLA region
a8 well as the 179 repbn
of the gencme
as the candMa1e ragions lo, the psoriasis gene in lhis family, we have con&dad that there vaa genetic hetetcgeneily in psoriasis and initiated a ~encrne-wide scan lo, genetic linkage with a panel cl314 Genethcn genetic ma&en ccverlng the whole human Qencme. Al tha presanl lime, wa have exdudDd80#cf~eQenomeanda,elinlshingthe scan. This work will lead lc the idendfkalicn of a new gene involved in psoriasis and will pmvide funhe, insight cn the elicbgical processes involved in Ihis lrequentdisepse.
9 ADULT T CELL LEUKEMIA DERIVED FACTOR IS INVOLVED IN ULTRAVIOLET B INDUCED MELANOGENES1-S BY UPREGULATING MSH RECEPTOR BINDING ACT,“,TY Ycka Funasaka,Ak,koOhash,. Mchkc NagaMma,Ashok K Chakraborty, Kobe Uw Masata Ueda, Hsdeya Ando. Masmmu Ich~hash~ Dept of Dermalology SChDd Of Meblclne. Kobe Japan Ultrav~olel B , UVB , IS known lo anduce act,ve oxygen spec,es I AOS , I” the ok,” The one Sklrl. howe”er. cO”n,eraclSAOS by bCfh SmCked arm newly produced anfloxldanls 0, such a”llox,dan,s Ad”,, Tel, Le”kem,a-Derived Facto, l ADF, ‘human hamoloaue Of
12 MELANOCYTIC NEVI IN SUN-PROTECTED CENTRAL ALBERTA CANADIAN
HUTTERITE
- CHILDREN _...-- .-..
T. Y. Kwan and T. Enta University of Calgary Total body melanccytic nevi (MN) were counted on Hutterite children living in Central Alberta, Canada. Hutterite children wear traditional clothes that provide continuous outdoor coverage to all parts of the body except the face and hands. A total of 332 children, aged 5 to 15, from 23 Hutterite colonies were examined. Of these children, 178 were male and 154 were famale. Nevi with diameters equal to or greater than 2 lllpl were counted on all body Surface areas except the scalp, buttocks, pubic region, and genitalia. In post pubescent females. breast area was not examined. Mean total body nevi in Hutterite children ranging in age fmm 5 to 15 was 2.34 and mean nevi increased with age at a rate of 0.5 nevi per yew. Both the mean number of nevi and the yearly rate of increase were lower than previously reported for children in similar age range. In addition, a sex difference in location of nevi was observed. Females had higher mean nevi on extremities than msles and males had a higher mean m on the torso than did females. Increases in nevi with age were primarily a function of increases on the extremities for females and on the torso for ales. The cccur~ence of this pattern in Hutterite children questions the explanation that this sex difference is due to differential exposure to sunlight between the sexes. Overall, the results were consistent withthe hypothesis that exposure to Sunlight produces greater numbers
of
nevi
in
Caucasians.