848. Granulation Tissue Formation Following the Administration of Recombinant Adenovirus Containing Vascular Endothelial Growth Factor-A165 (VEGF-A165)

848. Granulation Tissue Formation Following the Administration of Recombinant Adenovirus Containing Vascular Endothelial Growth Factor-A165 (VEGF-A165)

"   847. Cytotoxic Immune Response Following Retroviral-Mediated Hepatic Gene T ransfer in Rat Transfer Eliminates Beta-Galactosidase...

116KB Sizes 1 Downloads 72 Views

"   847. Cytotoxic Immune Response Following Retroviral-Mediated Hepatic Gene T ransfer in Rat Transfer Eliminates Beta-Galactosidase T ransduced Hepatocytes Transduced but Does Not Prevent Expression in AA V-T ransduced AAV -Transduced Muscles Nicolas Ferry,1 Dominique Aubert,1 Virginie Pichard.1 1 INSERM ERM 0105, CHU Hotel-Dieu, Nantes, France.              1       3             @          ''.        

                  

    

3             @      

        N       

            -/ E       

   



3     

 β"             -/       N ''.    

  

 β"    3  0             G         

 ''. 



  β"    3  #          



           -MB/  

     N         E  ,6                             

 ''.  N      E                

    -MB/    

           

 - ''.E          =9  /       β"      

    

  β"       2      3   

                 (           

   ;   =9     

               β"  



  &   B          "β"  

         

   =9         C                    β"    3      E 

   ''.   "β"                     ''. E  2      3            =                   ''.  E               

  β"    3        C               

               

 =9  '        

       β"    3   ''. 



          

 β"    3           β"    3           =                 

                  

    

   "  

     ''."  

   ) "                      

     

848. Granulation Tissue Formation Following the Administration of Recombinant Adenovirus Containing Vascular Endothelial Growth Factor-A165 (VEGF-A165)

David W. Kang,1 L. D. Looper,1 Xiao-Mei Jin,2 Erlinda M. Quijano,3 Monica L. Zepeda.1 1 Pharmacology, Canji Incorporated, San Diego, CA, United States; 2Molecular Biology and Biochemistry, Canji Incorporated, San Diego, CA, United States; 3Process Science, Canji Incorporated, San Diego, CA, United States. '                     G        

     . 

        -.>?/   

  

                            0    

       3  .>?"'8B& - ' " .>?"'8B&/      #.    @    -!.'/               

    ' " .>?"'8B&                  

      !.'     ' ".>?"'8B&   

 6;             

  ' "> =&B       

   

          899       

         !@  

Molecular Therapy Vol. 5, No. 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy

    

        ' ".>?"'8B&    !.'       

           .>?"'8B&   $*'     

     8 3 89; !*   8 3 8989 !*  ' ".>?"'8B&         

           .>?"'8B&          

                @   

   .>?"'8B&  

        86        

  

   8 3 8989 !* - ≤ 99&    ≤ 9998   

  ' ">    

     /    .>?"'8B& 

                     

                

849. Genetic Heterogeneity in Response to Adenovirus Gene Therapy Pierre Lefesvre,1 Joline Attema,1 Angelique Lemckert,1 Menzo Havenga,1 Dirk van Bekkum.1 1 Crucell B.V., Leiden, Netherlands. (       

        

 

              3         .       3          



 

         

     1

 

            

    C     

                        

          ?         

    ' & D     ' & DN   E 

                       89  899  

             DN            $*'         @*'            

                      89"       

3   

            3

                 899       

    



             3        

                      

  

 

                 



                  

                                           

850. Consequences of Chemotherapy Resistance and p53-Status for HSV-tk/GCV Based Suicide Gene Therapy Ingrid J. Van Dillen,1,2 Nanno H. Mulder,1 Lianne De Vries,1 Wendy A. Dam,1 Erik F. J. De Vries,2 Wim Vaalburg,2 Geke A. P. Hospers.1 1 Department of Medical Oncology, University Hospital Groningen, Groningen, Netherlands; 2PET-Center, University Hospital Groningen, Groningen, Netherlands. 56 + )7 '               3   "      -C(."/%  -./                     C(."  

        

      

                                  C(."        ."       "      

           3           &="      )7 0  

         

   C(." -B" A"8:/             -D6/         -@/  3  3    -D6"' D6"# )D6"$$!/              

       -',;:9"#./   

&=   8;&,6:   ,;=    -',;:9"8;& ',;:9",6: ',;:9",;=/ ."       "       

         G   ?          "     3    B" A"8:       D6   ',;:9       

  

     5B"       

       . -,&μ% /  )*)7 

    D6           ."          D6"@          -&9D6"@%&9D6/  D6"' D6"# )D6"$$!       8&5 85B   ,&= -O99=/    ?        "   -          

 

3 

   @2>/       D6     

 

S277