8606634 Mastitis vaccine

New Patents N H R ( a ) wherein R ( a ) is acyl, R ( b ) , COR(b), OR(b), OCOR(b), OR(b)-alkyl, S(O))m(R(b) wherein m is 0, 1 or 2 and R ( b ) is phenyl, naphthyl, indenyl, indanyl, phenanthridinyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, 1,2,4-triazinyl, furyl, thienyl, pyrrolyl, benzofuranyl, indolyl, imidazolyl, pyrazolyl, triazolyl or thiazolyl, SH, S(O))m( R(c), wherein R(c) is alkyl and m is 0, 1 or 2, S O ) 2 ( N R ( d ) R ( e ) , whrein R ( d ) and R(e) independently are hydrogen, alkyl or R ( b ) as defined herein, N H R ( c ) or N(R(c)))2(, wherein R(c) is as defined above; the dotted lines (.... ) represent optional double bonds in ring "M"; k is 0 or 1; p is 0, 1,2, 3, 4 or 5 provided that when Q is other than phenyl p is 0; A is hydrogen, alkyl, CH)2(CH)2(OH, COR(f"/, SO)2(R(f) wherein R(f) is hydrogen, alkyl, phenyl or substituted phenyl, or ( C H ) 2 ( ) ) q ( R ( g ) , wherein q is 1, 2, 3, 4 or 5 and R(g) is carboxyl or N R ' ) 2 ( , wherein R' is hydrogen or alkyl; n is 2 to 6 provided that when n is 3, ring E has no double bond between carbon atoms; and each z is independently hydrogen, alkyl or z's on adjacent carbon atoms together form a double bond, ring M is unsubstituted or substituted at its carbon atoms by alkyl groups, are useful in treating allergic diseases and inflammator7 diseases. Methods for preparing the compounds and methods for their use are also described.

A method for enhancing the ability for humoral immune response in a mammal comprising: exposing lymphocytes histocompatible with the lymphocytes of said mammal to the presence of polymeric or aggregated delta-immunoglobulin at a concentration higher than that at which said lymphocytes would have been exposed while in the lymph or bloodstream of said mammal; and introducing said lymphocytes to the bloodstream or lymph of said mammal.

8606634 MASTITIS VACCINE Dennis Leslie WATSON, 14 Sunset Avenue, Armidale, NSW 2350, Australia assigned to COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH OR A killed vaccine effective in the immunisation of ruminants against intramammary challenge by S.aureus, comprises antiphagocytic in vivo antigen(s) produced by a pseudocapsule-producing strain of S.aureus. An in vitro method of cultivating S.aureus under "simulated in vivo conditions" is also disclosed, together with methods for the production and use of the killed vaccine.

8606635 8606382 AVIAN ENCEPHALOMYELITIS ANTIBODY DETECTION Ian James SMART, 1 Hood Crescent, North Caulfield, VIC 3182, Australia assigned to THE STATE OF VICTORIA A mammalian anti-avian encephalomyelitis antiserum comprising the immunoglobulinfraction of mammalian blood serum containing antibodis to avian encephalomyelitis which antiserum is substantially free of anti-chicken immunoglobulin. The antiserum is used in a ELISA assay for the detection of avian encephalomyelitis.

8606490 METHOD FOR AUGMENTING IMMUNE RESPONSE Richard F COICO, Jeanette G THORBECKE assigned to NEW YORK UNIVERSITY

ORAL V A C C I N E S Gregory John RUSSELL-JONES, AIZPURUA Henry James DE, Peter HOWE, Keith Norman RAND, 101/2 Artarmon Road, Willoughby, NSW 2068, Australia assigned to BIOTECHNOLOGY AUSTRALIA PTY LTD; A complex of an immunogen with a carrier molecule and a method for presentation of the immunogen to mucosal epithelia of a host vertebrate in order to elicit a systemic, cellular, and/or mucosal immune response in the host vertebrate to the complex. The invention also provides processes for the production of the complex. Further the invention provides medicaments containing the complex as well as medicaments which additionally contain dietary molecules. The dietary molecules provides a means of selectively modulating the magnitude and/or type of immune response to the complex of the medicament. The invention provides means for inhibiting gonadal function in a mammal as well as for selectively modulating cellular immune response to a complex according to the invention.