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8607384 Process for preparing hapatitis B virus surface antigen p31
193
PATENT ABSTRACTS peptides of a natural amino acid sequence can be produced with industrial advantage from polypeptides produced, for example, by genetic engineering technology.
8607381 MONOCLONAL ANTIBODY TO MHS-5: A N E W P R O B E F O R SEXUAL ASSAULT ANALYSES John C HERR, Mark SIGMAN, William M SUTHERLAND assigned to THE UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATI A new probe for forensic analysis of sexual assaults. The probe is a monoclonal antibody to a new protein marker, MHS-5, in semen. Also disclosed is the bybridoma producing the antibody as well as an assay utilizing the antibody for forensic analysis of criminal evidence.
conventional dosage forms for peptide vaccines. or can be supplied in a recombinant vaccinia and the peptides synthesized in situ. Particularly useful autoantigens are those derived from hormones controlling reproduction. An easily administered and reversible vaccine for preventing human pregnancy is disclosed. The vaccine comprises a vaccinia virus vector modified to contain the DNA sequence encoding the Cterminal portion (CTP) of the beta-chain of human chorionic gonadotropin, or a multimer thereof. The vaccinia vectors are designed so that the encoded antigen is expressed internally by infected cells, or the CTP-encoding sequence is modified to provide a chimera which is capable of carrying the CTP)n( antigen to the surface of the infected cell and either presenting the CTP)n(antigen at the cell surface or of secreting it. In a preferred embodiment, the influenza hemagglutinin protein, or portions thereof, are used as the components of the chimera. Similar constructions which include alternate hormone derived sequences are also effective in humans and in other mammals. The antibodies obtained against and specific for these autoantigens are also useful.
8607~2 PROTECTIVE HUMAN MONOCLONAL ANTIBODIES TO PSEUDOMONAS AERUGINOSA) EXOTOXIN A Anthony W SIADAK, Mark E LOSTROM assigned to GENETIC SYSTEMS CORPORATION Cell lines have been produced that secrete human monoclonal antibodies capable of binding to and neutralizing Pseudomanas aeruginosa) exotoxin A. These antibodies have been found to be protective against lethal challenges of the exotoxin. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included.
8~7~4 PROCESS FOR PREPARING HAPATITIS B VIRUS SURFACE A N T I G E N P31 Masakazu KIKUCHI. Yukio FUJISAWA, Shuichi IKEYAMA. Osamu NISHIMURA, 416, Higashitokiwadai 7-chome, Toyono-cho, Toyono-gun. Osaka 563-01. Japan assigned to TAKEDA CHEMICAL INDUSTRIES LTD; Hepatitis B virus surface antigen P31 is prepared by culturing transformant containing recombinant DNA prepared by inserting P31-coding DNA to T-terminal of a promoter region.
8607464 METHODS FOR IDENTIFYING ALLELES ASSOCIATED WITH INCREASED RISK OF DIABETES
8~73~ AUTOANTIGEN
VACCINES
Karen D TALMADGE, John C FIDDES assigned to BIOTECHNOLOGY RESEARCH PARTNERS LTD; Autoantigen vaccines are obtained by conferring antigenicity by formation of multimers, of fusion proteins to non-bacterial sequences, or both. The vaccines can be administered using
Gerald T NEPOM, Barbara S NEPOM, Karen A NELSON assigned to GENETIC SYSTEMS CORPORATION Methods for identifying individuals at increased risk of diabetes. The methods utilize the discovery of the DQw3.2 variant, which identifies a specific allelic polymorphism at a single gene locus. One preferred method utilizes a labeled probe to detect the DQw3.2 allele. This method involves estimating the size of the hybridizable
PATENT ABSTRACTS peptides of a natural amino acid sequence can be produced with industrial advantage from polypeptides produced, for example, by genetic engineering technology.
8607381 MONOCLONAL ANTIBODY TO MHS-5: A N E W P R O B E F O R SEXUAL ASSAULT ANALYSES John C HERR, Mark SIGMAN, William M SUTHERLAND assigned to THE UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATI A new probe for forensic analysis of sexual assaults. The probe is a monoclonal antibody to a new protein marker, MHS-5, in semen. Also disclosed is the bybridoma producing the antibody as well as an assay utilizing the antibody for forensic analysis of criminal evidence.
conventional dosage forms for peptide vaccines. or can be supplied in a recombinant vaccinia and the peptides synthesized in situ. Particularly useful autoantigens are those derived from hormones controlling reproduction. An easily administered and reversible vaccine for preventing human pregnancy is disclosed. The vaccine comprises a vaccinia virus vector modified to contain the DNA sequence encoding the Cterminal portion (CTP) of the beta-chain of human chorionic gonadotropin, or a multimer thereof. The vaccinia vectors are designed so that the encoded antigen is expressed internally by infected cells, or the CTP-encoding sequence is modified to provide a chimera which is capable of carrying the CTP)n( antigen to the surface of the infected cell and either presenting the CTP)n(antigen at the cell surface or of secreting it. In a preferred embodiment, the influenza hemagglutinin protein, or portions thereof, are used as the components of the chimera. Similar constructions which include alternate hormone derived sequences are also effective in humans and in other mammals. The antibodies obtained against and specific for these autoantigens are also useful.
8607~2 PROTECTIVE HUMAN MONOCLONAL ANTIBODIES TO PSEUDOMONAS AERUGINOSA) EXOTOXIN A Anthony W SIADAK, Mark E LOSTROM assigned to GENETIC SYSTEMS CORPORATION Cell lines have been produced that secrete human monoclonal antibodies capable of binding to and neutralizing Pseudomanas aeruginosa) exotoxin A. These antibodies have been found to be protective against lethal challenges of the exotoxin. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included.
8~7~4 PROCESS FOR PREPARING HAPATITIS B VIRUS SURFACE A N T I G E N P31 Masakazu KIKUCHI. Yukio FUJISAWA, Shuichi IKEYAMA. Osamu NISHIMURA, 416, Higashitokiwadai 7-chome, Toyono-cho, Toyono-gun. Osaka 563-01. Japan assigned to TAKEDA CHEMICAL INDUSTRIES LTD; Hepatitis B virus surface antigen P31 is prepared by culturing transformant containing recombinant DNA prepared by inserting P31-coding DNA to T-terminal of a promoter region.
8607464 METHODS FOR IDENTIFYING ALLELES ASSOCIATED WITH INCREASED RISK OF DIABETES
8~73~ AUTOANTIGEN
VACCINES
Karen D TALMADGE, John C FIDDES assigned to BIOTECHNOLOGY RESEARCH PARTNERS LTD; Autoantigen vaccines are obtained by conferring antigenicity by formation of multimers, of fusion proteins to non-bacterial sequences, or both. The vaccines can be administered using
Gerald T NEPOM, Barbara S NEPOM, Karen A NELSON assigned to GENETIC SYSTEMS CORPORATION Methods for identifying individuals at increased risk of diabetes. The methods utilize the discovery of the DQw3.2 variant, which identifies a specific allelic polymorphism at a single gene locus. One preferred method utilizes a labeled probe to detect the DQw3.2 allele. This method involves estimating the size of the hybridizable