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8700436 The protection of equines against streptococcus equi
196
PATENT ABSTRACTS
amino acids, and culturing is continued into the decline phase of the culture to provide the product(s) of the cells. The process is particularly applicable to genetically modified cells, especially hybridoma cell cultures to produce monoclonal antibodies. Preferably, the supplemental feed is fed to the culture at a slow rate over a prolonged period. Very significant enhancement of overall product yield may be obtained.
8700196 PROTECTION OF PROTEINS THE LIKE
AND
Bruce Joseph ROSER, The Old Vicarage, Church Lane, Balsham, Cambridgeshire, United Kingdom assigned to QUADRANT BIORESOURCES LIMITED Sensitive proteins and other macromolecules, such as enzymes, antibodies, antigens, serum complement, fluorescent proteins, vaccine components, polysaccharides such as agarose etc, can be preserved by drying at ambient temperature and at atmospheric pressure in the presence of trehalose. A porous matrix impregnated with trehalose is provided as a receiver for a blood or other liquid sample to be dried.
8700436 THE PROTECTION OF EQUINES AGAINST STREPTOCOCCUS EQUI John F TIMONEY. John F TIMONEY assigned to CORNELL RESEARCH FOUNDATION INC; A new bacterial vaccine to protect susceptible equine against S. equi which causes strangles. The vaccine stimulates a nasopharyngeal immune response in a susceptible equine through the presence of antibody activity in the nasopharyngeal mucus. The vaccine is a S. equi strain which contains an M protein fragment of 41,000 mw and is adapted for administration to equine either intranasally or orally as a vaccine. There is described a new strain of S. equi (70927), a method of making and isolating useful vaccine strain of S. equi bacteria which stimulates an antibody response in the nasopharyngeal mucosa of the susceptible equine.
8700526 IMMUNOCHEMICAL ASSAYS FOR HUMAN AMYLASE ISOENZYMES AND RELATED MONOCLONAL ANTIBODIES, HYBRIDOMA CELL LINES AND PRODUCTION THEREOF David E BRUNS, David C BENJAMIN assigned to THE UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATI
8700201 EPITHELIAL CELLS EXPRESSING FOREIGN GENETIC MATERIAL Jeffrey R MORGAN, Richard C MULLIGAN assigned to WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH The foreign genetic material can be DNA or RNA which does not occur in epithelial cells; DNA or RNA which occurs in epithelial cells but is not expressed in them at levels which are biologically significant; DNA or RNA which occurs in epithelial and has been modified so that it is expressed in epithelial cells; and any DNA or RNA which can be modified to be expressed in epithelial cells, alone or in any combination thereof. In addition, epithelial cells can express genetic material encoding a selectable marker by which cells expressing the foreign genetic material can be expressed.
Immunoehemical assays for human amylase isoenzymes. These assays utilize monoclonal antibodies which are produced from hybridoma cell lines and are specific for human salivary type amylase but not human pancreatic amylase. The assays involve reacting this monoclonal antibody with the unknown sample for the purpose of studying quantitatively and qualitatively the amylase isoenzymes present. The results from such assays are useful in the diagnosis of disease or ruling out disease. Antibody producing hybridoma cell lines and their production.
8700531 MONOCLONAL ANTIBODIES AND THEIR USE Bruce William WRIGHT. Peter John COX. Alice Margaret NOYES, Danny WIDDOWS, 48 Bush Close, Comberton, Cambridgeshire CB3 7EG. United Kingdom assigned to TECHNOLOGY LICENCE COMPANY LIMITED
PATENT ABSTRACTS
amino acids, and culturing is continued into the decline phase of the culture to provide the product(s) of the cells. The process is particularly applicable to genetically modified cells, especially hybridoma cell cultures to produce monoclonal antibodies. Preferably, the supplemental feed is fed to the culture at a slow rate over a prolonged period. Very significant enhancement of overall product yield may be obtained.
8700196 PROTECTION OF PROTEINS THE LIKE
AND
Bruce Joseph ROSER, The Old Vicarage, Church Lane, Balsham, Cambridgeshire, United Kingdom assigned to QUADRANT BIORESOURCES LIMITED Sensitive proteins and other macromolecules, such as enzymes, antibodies, antigens, serum complement, fluorescent proteins, vaccine components, polysaccharides such as agarose etc, can be preserved by drying at ambient temperature and at atmospheric pressure in the presence of trehalose. A porous matrix impregnated with trehalose is provided as a receiver for a blood or other liquid sample to be dried.
8700436 THE PROTECTION OF EQUINES AGAINST STREPTOCOCCUS EQUI John F TIMONEY. John F TIMONEY assigned to CORNELL RESEARCH FOUNDATION INC; A new bacterial vaccine to protect susceptible equine against S. equi which causes strangles. The vaccine stimulates a nasopharyngeal immune response in a susceptible equine through the presence of antibody activity in the nasopharyngeal mucus. The vaccine is a S. equi strain which contains an M protein fragment of 41,000 mw and is adapted for administration to equine either intranasally or orally as a vaccine. There is described a new strain of S. equi (70927), a method of making and isolating useful vaccine strain of S. equi bacteria which stimulates an antibody response in the nasopharyngeal mucosa of the susceptible equine.
8700526 IMMUNOCHEMICAL ASSAYS FOR HUMAN AMYLASE ISOENZYMES AND RELATED MONOCLONAL ANTIBODIES, HYBRIDOMA CELL LINES AND PRODUCTION THEREOF David E BRUNS, David C BENJAMIN assigned to THE UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATI
8700201 EPITHELIAL CELLS EXPRESSING FOREIGN GENETIC MATERIAL Jeffrey R MORGAN, Richard C MULLIGAN assigned to WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH The foreign genetic material can be DNA or RNA which does not occur in epithelial cells; DNA or RNA which occurs in epithelial cells but is not expressed in them at levels which are biologically significant; DNA or RNA which occurs in epithelial and has been modified so that it is expressed in epithelial cells; and any DNA or RNA which can be modified to be expressed in epithelial cells, alone or in any combination thereof. In addition, epithelial cells can express genetic material encoding a selectable marker by which cells expressing the foreign genetic material can be expressed.
Immunoehemical assays for human amylase isoenzymes. These assays utilize monoclonal antibodies which are produced from hybridoma cell lines and are specific for human salivary type amylase but not human pancreatic amylase. The assays involve reacting this monoclonal antibody with the unknown sample for the purpose of studying quantitatively and qualitatively the amylase isoenzymes present. The results from such assays are useful in the diagnosis of disease or ruling out disease. Antibody producing hybridoma cell lines and their production.
8700531 MONOCLONAL ANTIBODIES AND THEIR USE Bruce William WRIGHT. Peter John COX. Alice Margaret NOYES, Danny WIDDOWS, 48 Bush Close, Comberton, Cambridgeshire CB3 7EG. United Kingdom assigned to TECHNOLOGY LICENCE COMPANY LIMITED