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8702267 Blood serum test strip
405
PATENT ABSTRACTS 96-101 has been modified to isoaspartic acid. Processes for the production of these bioenhanced compositions and for their use are also disclosed.
bacterial, fungal, and parasitic infection, especially in immunologically compromised patients such as these suffering from AIDS. 8702~2
8702059 POLYMORPHISMS RELATED TO LIPID METABOLISM PREDICTIVE OF ATHEROSCLEROSIS: APOB, APOCII, APOE, APOAIV Philippe M FROSSARD, Philippe M FROSSARD assigned to BIOTECHNOLOGY RESEARCH PARTNERS LTD; Polymorphisms in genes related to lipid metabolism, specifically apolipoproteins B, CII, E, and apoAIV, have been identified. Presence or absence of these polymorphisms in particular individuals may be correlated with propensity to show symptoms of atherosclerosis. Also thus correlated are two insertion polymorphisms (5') of the insulin gene.
8702060 HUMAN GRANULOCYTEMACROPHAGE COLONY STIMULATING FACTOR-LIKE POLYPEPTIDES AND PROCESSES FOR PRODUCING THEM IN HIGH YIELDS IN MICROBIAL CELLS John DeLAMARTER, Joachim F ERNST, Joachim F ERNST, Chemin des Goulettes 13, CH-1256 Troinex, Switzerland assigned to B10GEN N V; Granulocyte-macrophage colony stimulating factor-like polypeptides having a specific activity of at least 1 x 10(8) Units/rag and methods of making these products. DNA sequences and recombinant DNA molecules and microbial hosts transformed with them which produce human granulocyte-macrophage colony stimulating factor-like polypeptides in high yields, and methods of making these polypeptides. The human granulocyte-macrophage colony stimulating factor-like polypeptides of this invention may be used to treat cancer patients to regenerate leukocytes after radiation or chemotherapy treatment, and to increase white blood cell count to reduce the likelihood of viral,
RECOMBINANT APOLIPOPROTEINS METHODS
AND
Andrew A PROTTER, Jean-Louis VIGNE, Joanne B MALLORY, Karen D TALMADGE, John P KANE assigned to BIOTECHNOLOGY RESEARCH PARTNERS
LTD; A method of producing a purified lipid-binding peptide which can bind to phospholipids at one or more amphipatic alpha-helical peptide regions. The method includes providing a gene coding for the peptide, and introducing the gene in expressible, heterologous form in a suitable expression system capable of synthesizing a mixture of peptides which includes the lipid-binding peptide. Addition of either endogenous or exogenous lipids to the peptide mixture forms a low-density lipopeptide complex composed of lipid and the lipid-binding peptide, and this complex can be separated easily from nonlipidbinding peptides in the peptide on the basis of its size and/or density. The method is intended particularly for scaled-up production of purified human apolipoproteins and their alpha-helical lipid-binding regions. Also disclosed are related methods for producing recombinant apolipoproteins, therapeutic lipopeptide compositions, and a stabilized lipid emulsion for nutritional therapy. Further disclosed are methods for expressing apolipoproteins or lipidbinding segments thereof in bacterial, yeast and mammalian cell expression systems, and methods for purifying lipid binding proteins, including fused recombinant proteins. 8702267 BLOOD
SERUM
TEST STRIP
Paul R KENNEDY, Ernest C ADAMS, William E WOENKER assigned to CHEM-ELEC INC: Single or multiple blood plasma component concentrations are measured by a disposable stick (63) having one or more plasma component reactive areas (31. 91) covered by a semipermeable membrane (13) which is permeable to
PATENT ABSTRACTS 96-101 has been modified to isoaspartic acid. Processes for the production of these bioenhanced compositions and for their use are also disclosed.
bacterial, fungal, and parasitic infection, especially in immunologically compromised patients such as these suffering from AIDS. 8702~2
8702059 POLYMORPHISMS RELATED TO LIPID METABOLISM PREDICTIVE OF ATHEROSCLEROSIS: APOB, APOCII, APOE, APOAIV Philippe M FROSSARD, Philippe M FROSSARD assigned to BIOTECHNOLOGY RESEARCH PARTNERS LTD; Polymorphisms in genes related to lipid metabolism, specifically apolipoproteins B, CII, E, and apoAIV, have been identified. Presence or absence of these polymorphisms in particular individuals may be correlated with propensity to show symptoms of atherosclerosis. Also thus correlated are two insertion polymorphisms (5') of the insulin gene.
8702060 HUMAN GRANULOCYTEMACROPHAGE COLONY STIMULATING FACTOR-LIKE POLYPEPTIDES AND PROCESSES FOR PRODUCING THEM IN HIGH YIELDS IN MICROBIAL CELLS John DeLAMARTER, Joachim F ERNST, Joachim F ERNST, Chemin des Goulettes 13, CH-1256 Troinex, Switzerland assigned to B10GEN N V; Granulocyte-macrophage colony stimulating factor-like polypeptides having a specific activity of at least 1 x 10(8) Units/rag and methods of making these products. DNA sequences and recombinant DNA molecules and microbial hosts transformed with them which produce human granulocyte-macrophage colony stimulating factor-like polypeptides in high yields, and methods of making these polypeptides. The human granulocyte-macrophage colony stimulating factor-like polypeptides of this invention may be used to treat cancer patients to regenerate leukocytes after radiation or chemotherapy treatment, and to increase white blood cell count to reduce the likelihood of viral,
RECOMBINANT APOLIPOPROTEINS METHODS
AND
Andrew A PROTTER, Jean-Louis VIGNE, Joanne B MALLORY, Karen D TALMADGE, John P KANE assigned to BIOTECHNOLOGY RESEARCH PARTNERS
LTD; A method of producing a purified lipid-binding peptide which can bind to phospholipids at one or more amphipatic alpha-helical peptide regions. The method includes providing a gene coding for the peptide, and introducing the gene in expressible, heterologous form in a suitable expression system capable of synthesizing a mixture of peptides which includes the lipid-binding peptide. Addition of either endogenous or exogenous lipids to the peptide mixture forms a low-density lipopeptide complex composed of lipid and the lipid-binding peptide, and this complex can be separated easily from nonlipidbinding peptides in the peptide on the basis of its size and/or density. The method is intended particularly for scaled-up production of purified human apolipoproteins and their alpha-helical lipid-binding regions. Also disclosed are related methods for producing recombinant apolipoproteins, therapeutic lipopeptide compositions, and a stabilized lipid emulsion for nutritional therapy. Further disclosed are methods for expressing apolipoproteins or lipidbinding segments thereof in bacterial, yeast and mammalian cell expression systems, and methods for purifying lipid binding proteins, including fused recombinant proteins. 8702267 BLOOD
SERUM
TEST STRIP
Paul R KENNEDY, Ernest C ADAMS, William E WOENKER assigned to CHEM-ELEC INC: Single or multiple blood plasma component concentrations are measured by a disposable stick (63) having one or more plasma component reactive areas (31. 91) covered by a semipermeable membrane (13) which is permeable to