881. Comparative Study Demonstrates AAV-5 Is Superior to AAV-2 in Transduction after In Utero and Postnatal Delivery

881. Comparative Study Demonstrates AAV-5 Is Superior to AAV-2 in Transduction after In Utero and Postnatal Delivery

"   G 7 8/          20 -        /       ...

141KB Sizes 2 Downloads 16 Views

"   G

7 8/          20 -        /      

  ? -  "   3  8 

/I ,/  

            

   "       ?  " 

            3   

         

   '  3 $*'        ( 1         

      

      

 3        D?  * ?     "   "      (   

   

     

 7 8/            

    "     -     +   3   ",    !        &"C & 2$*?/    

 -         

  /I ,/  "     D"8  D"B D"5 -  

/   "   D"89D"8=- 

/     

       

   *(I =/  " -2)$/        -2"#/    -  

/I 6/        "  C ,;    "8      " , - 

/   &/    

      

       -()("=/ - 

/ )          

              

         

         3              "         

              

       -    )"@@CA'2'"'         "        &"C , D4 6      $8/     -#'!"       "   

   /       -6       D"8: #/        

        

        

  



  "     

     "                 3       *(                 "  

            

                      "   

881. Comparative Study Demonstrates AA V-5 Is AAV Superior to AA V-2 in T ransduction after In Utero and AAV Transduction Postnatal Delivery Gerald S. Lipshutz,1 Debra Titre,2 Christopher H. Contag,3 Karin M. L. Gaensler.2 1 Department of Surgery, University of California, San Francisco, California, United States; 2Department of Medicine, University of California, San Francisco, California, United States; 3Department of Pediatrics, Stanford University, Palo Alto, California, United States.               

   "                          >         

           

       )          

 "  3  -T8&   /       E     " 

   - ''./ 0     

            3    

     ->?8α   #./ 

    "    

$*'    ''.   -,   &/ (   ,   & ''. 

  

         (   ,    

   

>?8α- ''.",>?8α/  #.- ''.",#./    ''."&    

   #.              

   -0!@>/ - ''."& #./ !      E 

     

 8&      

       >       E 

  =38988      ''. S         

3    G

 G     "

           

    '      

  , 

         3       #    "E 

 -!/  ,9    ,3898,    ''.",#.   3

89   =&     E  (       

     '     E    ''.",   &    3

     , 

  '   3 

 "     3  ' 

   3     

      ''.", >?8α    )     3   

    - 3  T8&    ''.",>?8αI 3 T,,   ''.",#.I

3 T=   ''."&#.Q    R/>3    ''.", #.   L,           ''.", >?8α

Molecular Therapy Vol. 5, No. 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy

''."& #.      

 3  L8,          ''.",#.    3     - ''.",>?8α7 ''." ,#.7 ''."&#./ 8789678B=B   ',9   ''." , >?8α E           3            " E    65=389B±:6&389&             " E 

   ,3898,      ''.", #.      "E        8=:389;±;95389B         =&    "E  =5=389;±;69389B               3   L:                      

3        

                  ''.    (   &"

            3    

     ,     #.              3   >?8α        2  ''.   3  "  3    

  E  >3      

       

        3     I    

  ! ''.                     

3  !        ''. 

                       

                      

882. Use of Replication Competent Retroviral V ectors Vectors (RCR) in Malignant Gliomas Weijun Wang,1 Chienkuo Tai,2 Noriyuki Kasahara,2 Thomas C. Chen.1,3 1 Department of Neurosurgery, University of Southern California, Los Angeles, California, United States; 2Institute of Genetic Medicine, University of Southern California, Los Angeles, California, United States; 3Department of Pathology, University of Southern California, Los Angeles, California, United States. #                  '             3  

  -C(." A/   %.           G

                

           C               

        E              -@@/  C(." A 

            -./                   

                        

   @@                           

   

         -@@/    

       -?!/      -8/ 0      

   @@              -'"8;,4":; "5:4"8=:/  "     @@                           @@"?! E 

          (   $                     0 @@"?!-8389&4%899/E 

  

   4":;      %   @@ ?!        ;9BH 59=H 5:;H        , 6 B 

     ) 

    @@"?! -8 3 89& 4%899/   8,H   9,H  ,   B 

     )        @@"?!             

  @@"?!      8 D @  A D '   C     8,7 5,8"=, ,998

883. T ransferable Autoimmune Regulation Induced by Transferable V-Mediated vIL-10 Gene Therapy AAV AA Zandong Yang, Meng Chen, Lawrence B. Fialkow, Runpei Wu, Marcia J. McDuffie, Jerry L. Nadler. 0         

   ''.   D"89 -D"89/  

   

           -*)$/            

       

  ''. D"89      #   7 -8/     E    D"89   G    ''. D"89" 

 *)$   -,/ $    D"89 @*'      

   ''. D"89" 

   -=/ '                *)$     "  *)$   @  7  "    *)$    

S287