- Email: [email protected]
881. Quantifying Social Interaction in Borderline Personality Disorder
Biological Psychiatry
Saturday Abstracts
express DT receptors. Decision-making was then reassessed in the PRL task. Results: Ablation of OFC neurons projecting to the nucleus accumbens impaired the ability of rats to flexibly adjust their decision-making in the PRL by reducing the influence of negative outcomes on decision-making. In contrast, ablation of OFC neurons projecting to the amygdala improved PRL performance by increasing the influence of positive outcomes on future decision-making. Conclusions: These data indicate that distinct OFC circuits mediate dissociable components of decision-making. By combining sophisticated viral approaches with translationally analogous behavioral assessments, these data suggest that decision-making may be a useful biomarker for understanding OFC pathophysiology in mental disorders. Supported By: R01 DA043443; T32 MH14276 Keywords: Orbitofrontal Cortex, reversal learning, corticolimbic, Impulsivity, Decision Making
881. Quantifying Social Personality Disorder
Interaction
in
Borderline
Sarah Fineberg1, Jacob Leavitt1, Dylan Stahl1, Chris Landry2, and Philip Corlett1 1
Yale University, 2Columbia University
Background: People with Borderline Personality Disorder have social attributions that are extreme and often difficult to revise. Negative attribution bias has been previously demonstrated. We extend this work by quantifying social behaviors in two interactive contexts: first, regulation of interpersonal space (social distance task), and second, reward learning for social and non-social cues (social valuation task, SVT). Methods: Female BPD and control subjects interacted with a confederate for both tasks. Between-group behavior was compared using t-tests and mixed-effects models. We tested for relationships between behavior and psychological variables with Pearson’s correlations. Results: Preferred social distance was two-fold greater in BPD versus control (control n530, mean511.03”, SD55.7; BPD n523, mean521.11”, SD511.75; t524.12, p,0.001). However, in the BPD group, preferred distance does not correlate with mood, anxiety, impulsivity, or BPD symptoms (p,0.05), and preferred distance does not differ by medication status or by previous diagnosis (p.0.05). In the SVT, there were significant group x predictor effects revealing less weight on non-social and more weight on social predictors in BPD (p, 0.0005). Conclusions: Interactive social tasks allow us to precisely define differences and similarities in social behavior and learning in BPD, extending psychological theory and previous non-interactive methods. Quantitative markers of social deficits in BPD will allow us to measure the efficacy of current interventions (using markers to track treatment), define sub-groups that may respond differentially to treatment (using markers to predict outcome), and investigate relevant brain networks to develop neural targets for intervention (using markers as probes for key circuits).
S356
Supported By: NARSAD Young Investigator Grant Keywords: Social Cognition, Borderline Personality Disorder, Reinforcement learning
882. The Relationship between Catastrophizing, Perception of Disability, and Memory in Veterans with Chronic Pain Margaret Legarreta1, Elliott Bueler2, Jennifer DiMuzio2, Erin McGlade2, and Deborah Yurgelun-Todd2 1
VA Salt Lake City, 2University of Utah
Background: Chronic pain is associated with a variety of psychiatric symptoms including depression and suicide. Memory difficulties also are a primary complaint among people with chronic pain. Most research to date has focused on pain intensity, with results showing that more severe or intense pain is related to more impaired memory. Limited research has focused on negative cognition (catastrophizing or negative thinking patterns) as a contributor to memory deficits in patients with chronic pain. This study will examine cognitive factors of pain (i.e., catastrophizing and perception of disability) that may impact memory. Methods: Participants included 80 veterans (mean age 5 36.93, 82.5% male) from the Salt Lake City area. Participants completed pain measures (McGill Pain Inventory, Pain Catastrophizing Scale, and the Pain Disability Scale) and the CVLT-II to assess memory and learning. Bivariate correlations were utilized to assess the relationship between pain characteristics and learning, short-term, and long-term memory. Results: Pain catastrophizing was negatively related to learning (Trials 1-5, p50.007) and memory (short free recall, p50.006 and long free recall, p50.016). Perceived disability due to pain also was negatively related to learning (Trials, 1-5 p50.043) and memory (short free recall, p50.019 and long free recall, p50.010). Conclusions: These findings suggest that pain intensity alone may not sufficiently describe the cognitive concerns among people with chronic pain. Pain and memory have been shown to share common central nervous system pathways (Liu et al., 2000); as such, research examining these common pathways may provide new insights for improved treatment approaches. Supported By: Military Suicide Research Consortium (MSRC), an effort supported by the Office of the Assistant Secretary of Defense for Health Affairs under Award No. W81XWH-10-2-0178; Merit Review 5I01CX000253-02 Keywords: Memory, chronic pain, catastrophizing, perceived disability
883. Is Categorical Perception of Syllables Intact in Long-Term and First-Episode Schizophrenia? Rebecca M Laher, Sarah Haigh, Timothy K Murphy, Brian A Coffman, Kayla L Ward, Justin R Leiter, and Dean Salisbury University of Pittsburgh School of Medicine Background: Schizophrenia is associated with deficits in language processing, thought to reflect left frontal and temporal cortex abnormalities. Positive symptoms tend to be
Biological Psychiatry May 15, 2017; 81:S277–S413 www.sobp.org/journal
Saturday Abstracts
express DT receptors. Decision-making was then reassessed in the PRL task. Results: Ablation of OFC neurons projecting to the nucleus accumbens impaired the ability of rats to flexibly adjust their decision-making in the PRL by reducing the influence of negative outcomes on decision-making. In contrast, ablation of OFC neurons projecting to the amygdala improved PRL performance by increasing the influence of positive outcomes on future decision-making. Conclusions: These data indicate that distinct OFC circuits mediate dissociable components of decision-making. By combining sophisticated viral approaches with translationally analogous behavioral assessments, these data suggest that decision-making may be a useful biomarker for understanding OFC pathophysiology in mental disorders. Supported By: R01 DA043443; T32 MH14276 Keywords: Orbitofrontal Cortex, reversal learning, corticolimbic, Impulsivity, Decision Making
881. Quantifying Social Personality Disorder
Interaction
in
Borderline
Sarah Fineberg1, Jacob Leavitt1, Dylan Stahl1, Chris Landry2, and Philip Corlett1 1
Yale University, 2Columbia University
Background: People with Borderline Personality Disorder have social attributions that are extreme and often difficult to revise. Negative attribution bias has been previously demonstrated. We extend this work by quantifying social behaviors in two interactive contexts: first, regulation of interpersonal space (social distance task), and second, reward learning for social and non-social cues (social valuation task, SVT). Methods: Female BPD and control subjects interacted with a confederate for both tasks. Between-group behavior was compared using t-tests and mixed-effects models. We tested for relationships between behavior and psychological variables with Pearson’s correlations. Results: Preferred social distance was two-fold greater in BPD versus control (control n530, mean511.03”, SD55.7; BPD n523, mean521.11”, SD511.75; t524.12, p,0.001). However, in the BPD group, preferred distance does not correlate with mood, anxiety, impulsivity, or BPD symptoms (p,0.05), and preferred distance does not differ by medication status or by previous diagnosis (p.0.05). In the SVT, there were significant group x predictor effects revealing less weight on non-social and more weight on social predictors in BPD (p, 0.0005). Conclusions: Interactive social tasks allow us to precisely define differences and similarities in social behavior and learning in BPD, extending psychological theory and previous non-interactive methods. Quantitative markers of social deficits in BPD will allow us to measure the efficacy of current interventions (using markers to track treatment), define sub-groups that may respond differentially to treatment (using markers to predict outcome), and investigate relevant brain networks to develop neural targets for intervention (using markers as probes for key circuits).
S356
Supported By: NARSAD Young Investigator Grant Keywords: Social Cognition, Borderline Personality Disorder, Reinforcement learning
882. The Relationship between Catastrophizing, Perception of Disability, and Memory in Veterans with Chronic Pain Margaret Legarreta1, Elliott Bueler2, Jennifer DiMuzio2, Erin McGlade2, and Deborah Yurgelun-Todd2 1
VA Salt Lake City, 2University of Utah
Background: Chronic pain is associated with a variety of psychiatric symptoms including depression and suicide. Memory difficulties also are a primary complaint among people with chronic pain. Most research to date has focused on pain intensity, with results showing that more severe or intense pain is related to more impaired memory. Limited research has focused on negative cognition (catastrophizing or negative thinking patterns) as a contributor to memory deficits in patients with chronic pain. This study will examine cognitive factors of pain (i.e., catastrophizing and perception of disability) that may impact memory. Methods: Participants included 80 veterans (mean age 5 36.93, 82.5% male) from the Salt Lake City area. Participants completed pain measures (McGill Pain Inventory, Pain Catastrophizing Scale, and the Pain Disability Scale) and the CVLT-II to assess memory and learning. Bivariate correlations were utilized to assess the relationship between pain characteristics and learning, short-term, and long-term memory. Results: Pain catastrophizing was negatively related to learning (Trials 1-5, p50.007) and memory (short free recall, p50.006 and long free recall, p50.016). Perceived disability due to pain also was negatively related to learning (Trials, 1-5 p50.043) and memory (short free recall, p50.019 and long free recall, p50.010). Conclusions: These findings suggest that pain intensity alone may not sufficiently describe the cognitive concerns among people with chronic pain. Pain and memory have been shown to share common central nervous system pathways (Liu et al., 2000); as such, research examining these common pathways may provide new insights for improved treatment approaches. Supported By: Military Suicide Research Consortium (MSRC), an effort supported by the Office of the Assistant Secretary of Defense for Health Affairs under Award No. W81XWH-10-2-0178; Merit Review 5I01CX000253-02 Keywords: Memory, chronic pain, catastrophizing, perceived disability
883. Is Categorical Perception of Syllables Intact in Long-Term and First-Episode Schizophrenia? Rebecca M Laher, Sarah Haigh, Timothy K Murphy, Brian A Coffman, Kayla L Ward, Justin R Leiter, and Dean Salisbury University of Pittsburgh School of Medicine Background: Schizophrenia is associated with deficits in language processing, thought to reflect left frontal and temporal cortex abnormalities. Positive symptoms tend to be
Biological Psychiatry May 15, 2017; 81:S277–S413 www.sobp.org/journal