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9. Assessment of Intrathoracic Metastatic Lung Cancer using FDG-PET and CT of the Thorax
PII S1095-0397(00)00075-3
Clinical Positron Imaging Vol. 3, No. 4, 163. 2000 Copyright 2000 Elsevier Science Inc. Printed in the USA. All rights reserved. 1095-0397/00 $–see front matter
POSTER PRESENTATIONS
9. Assessment of Intrathoracic Metastatic Lung Cancer using FDG-PET and CT of the Thorax Mascaro F., Bisker J., Abdel-Nabi, H. Department of Nuclear Medicine & Radiology, The State University of New York at Buffalo, and Center for Positron Emission Tomography, Western New York HealthCare, Buffalo, NY
Purpose: The purpose of this study was to assess the accuracy in localizing mediastinal, hilar and intraparenchymal lymphadenopathy in patients with primary lung carcinomas, using FDG-PET and CT of the thorax and to correlate with surgical pathology. Method: Thirty-five patients with primary lung carcinomas and minimal metastatic lymph node involvement, (either N⭋ or N1 disease) underwent FDG-PET and CT of the thorax prior to surgical intervention. Both FDG-PET and CT of the thorax were blindly read independent of one another. Results: Histologically, 23 patients had negative lymph nodes (N⭋) and 12 patients had N1 disease. The imaging performance characteristics for FDG-PET and CT of the thorax in N⭋/N1 disease was evaluated and reported in Table 1. Table 1. Imaging performance characteristics
sensitivity specificity accuracy positive predictive II value negative predictive II value
FDG-PET (%)
CT of the Thorax (%)
58 87 77 70 80
67 65 66 50 79
Conclusion: This study demonstrates the higher specificity, accuracy, PPV, and NPV of FDGPET over CT of the thorax in patients with minimal lymph node disease. (Clin Pos Imag 2000;3:163) 2000 Elsevier Science Inc. All rights reserved.
163
Clinical Positron Imaging Vol. 3, No. 4, 163. 2000 Copyright 2000 Elsevier Science Inc. Printed in the USA. All rights reserved. 1095-0397/00 $–see front matter
POSTER PRESENTATIONS
9. Assessment of Intrathoracic Metastatic Lung Cancer using FDG-PET and CT of the Thorax Mascaro F., Bisker J., Abdel-Nabi, H. Department of Nuclear Medicine & Radiology, The State University of New York at Buffalo, and Center for Positron Emission Tomography, Western New York HealthCare, Buffalo, NY
Purpose: The purpose of this study was to assess the accuracy in localizing mediastinal, hilar and intraparenchymal lymphadenopathy in patients with primary lung carcinomas, using FDG-PET and CT of the thorax and to correlate with surgical pathology. Method: Thirty-five patients with primary lung carcinomas and minimal metastatic lymph node involvement, (either N⭋ or N1 disease) underwent FDG-PET and CT of the thorax prior to surgical intervention. Both FDG-PET and CT of the thorax were blindly read independent of one another. Results: Histologically, 23 patients had negative lymph nodes (N⭋) and 12 patients had N1 disease. The imaging performance characteristics for FDG-PET and CT of the thorax in N⭋/N1 disease was evaluated and reported in Table 1. Table 1. Imaging performance characteristics
sensitivity specificity accuracy positive predictive II value negative predictive II value
FDG-PET (%)
CT of the Thorax (%)
58 87 77 70 80
67 65 66 50 79
Conclusion: This study demonstrates the higher specificity, accuracy, PPV, and NPV of FDGPET over CT of the thorax in patients with minimal lymph node disease. (Clin Pos Imag 2000;3:163) 2000 Elsevier Science Inc. All rights reserved.
163