90250420 Influence of menopause on the auditory brainstem response

164

lip&lipoprotein profiles and cardiovascular disease are limited in women, current evidence suggests that total cholesterol and possibly low-density lipoprotein cholesterol are risk factors. We conclude that during the first 12 months of treatment, tamoxifen exerts a favorable effect on the lipid profile in postmenopausal women with early stage breast cancer. 90241589 CootInuons as&tiv*passive exercise and cycle ergometer training in sedentary women Martin D.; Kauwell G.P.A. Department FL 32610

of Physical Therapy, College of Health Related Professions,

University of Florida, Gainesville,

MED. SCI. SPORTS EXERC. 1990 22/4 (523-527) Continuous assistive-passive exercise (CAPE) is a new exercise modality that has become popular with older females. To evaluate the efficacy of CAPE, 43 sedentary, postmenopausal women (PMW) were randomly divided into three groups: CAPA training (N = 15). cycle ergometer training (N = 14), and control (N = 14). The CAPE training consisted of 10 min bouts on six CAPE tables, twice per week. The cycle ergometer group trained twice per week for 30 min per session, at 70-85% of maximal heart rate. The cycle ergometer and CAPE groups trained for 12 wk, while the control group remained sedentary for the duration of the study. Groups were similar with respect to age, height, weight, girths, skinfolds, and aerobic power (VG(2max)) upon entering the study (P > 0.05). The groups were tested pre- and post-training on the sum of seven body girths (7G), sum of four skinfolds (E4SF), weight, and VD(2max). A 3 d dietary recall was recorded pre and post and analyzed for total caloric intake. Following training, changes in caloric intake, C7G, and E4SF were not significantly different in among groups. The cycle group lost 1.I kg (P &It; 0.05) and increased VO(2max) (I*min-t) by 9.2% (P & It; 0.05), while the CAPE group significantly decreased VO(2max) (P = 0.04). Our results indicate that CAPE does not alter C7G or E4SF in sedentary PMW and that two 30 min sessions of cycle training per week at 7045% of maximal heart rate can result in moderate but significant increases in VO(2max) in sedentary PMW. 90250420 InfIB of menopause 00 the auditory brainstem respome Wharton J.A.; Church G.T. Henry Ford Hospital,

AUDIOLOGY

Detroit,

MI

1990 29/4 (196-201)

Auditory brainstem response (ABR) wave latency, interpeak interval and amplitude as a function of intensity were measured in 40 subjects divided into equal groups of postmenopausal females, age-matched males and young adults of both sexes. The results illustrate that age and gender play a significant role in ABR wave latency and amplitude. A larger age effect occurred for the female subjects. While this does not dispute an anatomical explanation for the gender effect in ABR, hormonal changes accompanying menopause may also account for some of the gender differences noted in ABR. 90251860 EvaInatIon of the hypocholesterolemic activity of pantethine in perimenopausal women Binaghi P.; Cellina G.; Lo Cicero G.; Bruschi F.; Porcaro E.; Penotti M. Servizio di Cardiologia,

Istituti

Clinici di Perfezionamento.

Yin Commenda.

20122 Milan0

MINERVA MED. 1990 81/6 (475-%79) Cardiovascular diseases are the main cause of death also in women. Their incidence, rapidly growing in the peri-menopausal period, is related to serum levels of total cholesterol and its LDL fraction. It was also shown that the peroxidation of LDL is an additional factor in the genesis of atherosclerotic vascular disease. As long-term treatments with synthetic lipid-lowering drugs may cause undesiderable side effects, while pantethine is known to be well tolerated, we treated 24 hypercholesterolemic women (total serum cholesterol ~240 mg/dl), in perimenopausal age (range: 45-55 years, mean f SD = 5 I .6 f 2.4) with 900 mg/day of pantethine. This is a precursor of coenxyme A, with an antiperoxidation effect in viva. and