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90364117 Relationship between trunk muscle torque and bone mineral content of the lumbar spine and hip in healthy postmenopausal women
254 90364117 Relationship between trunk muscle torque and bone mineral content of the lumbar spine and hip in healthy postmenopausal women
Halle J.S.; Smidt G.L.: O’Dwyer K.D.; Lin S.-Y. PHYS. THER. 1990 70/l I (690-699) The purpose of the study was to determine the relationship between trunk muscle strength and bone mineral density (BMD). Fifty-six postmenopausal women, aged 38 to 73 years, were examined. The BMD of lumbar vertebrae L24, the femoral neck, the Ward’s triangle, and the greater trochanter was measured with dual-photon absorptiometry. Isometric and isokinetic torque and work measurements obtained on a trunk testing unit were used to assess trunk flexor and extensor strength. Correlation analysis demonstrated a statistically significant relationship between most trunk torque and work measurements and BMD. The trunk extensors generally provided higher correlations with BMD than did the trunk flexors, and the isokinetic extension torque values demonstrated higher correlations than the isometric extension values in every case. Linear backward-regression models, based on the subjects’ weight and trunk flexor and extensor torque and work measurements, demonstrated multiple-correlation coefficients of .67, S8, .43, and .65 in predicting the BMD of the L24 region, femoral neck, Ward’s triangle, and greater trochanter region. respectively. Estrogen therapy status did not affect the linear regression models. These data suggest a positive relationship in postmenopausal women between flexor and extensor torque values and BMD at the lower lumbar spine and proximal femur. [Halle JS, Smidt GL. O’Dwyer KD, Lin S-Y. Relationship between trunk muscle torque and bone mineral content of the lumbar spine and hip in healthy postmenopausal women.
90365401 Selective depression of metabolic activities in cortical osteoblasts at the site of femoral neck fractures
Dodds R.A.; Emery R.J.H.; Klenerman L.: Chayen J.; Bitensky L. Division of Cellular Biology,
The Kennedy Institute of Rheumatology,
Bute Gardens, London, W6 70 W
BONE 1990 I l/3 (157-161) The aim of this investigation was to determine whether some metabolic defect might be related to the propensity of osteoporotic femoral necks to fracture acutely. To this end, the activities of two dehydrogenases of the glycolytic Embden-Meyerhof pathway, two of the pentose phosphate pathway, two mitochondrial enzymes, and alkaline phosphatase were measured in the cortical and in the trabecular osteoblasts. Comparison was made with such activities in iliac crest biopsies from patients with these fractures and from the equivalent femoral and iliac crest samples from patients with osteoarthritis of the hip, in biopsies from the iliac crests from seven patients with no bony abnormality, and in specimens from the fracture site of six traumatic fractures. The results showed a highly significant decrease in the activities of the two enzymes of the pentose phosphate pathway (p < 0.001) in the cortical, but not in the trabecular, osteoblasts in the osteoporotic fractures. This could not be attributed to the trauma of acute fracture since it was not found in traumatic fractures. Other experimental evidence has indicated that a relationship may occur between depressed activity of these enzymes and a retardation of bone formation.
90365515 Transdermal estradiol. A review of ib pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of menopausal complaints
Balfour J.A.; Heel R.C. Adis Drug Information
Services, Adis International
Ltd., 41 Centorian Drive, Auckland
DRUGS 1990 40/4 (561-582) The estradiol transdermal therapeutic system is a cutaneous delivery device which delivers estradiol into the systemic circulation via the stratum corneum at a constant rate for up to 4 days. Physiological levels of estradiol (the major estrogen secreted by the ovaries in premenopausal women) can therefore be maintained in postmenopausal women with low daily doses because first-pass hepatic metabolism is avoided. In short term clinical studies, the beneficial effects of transdermal estradiol on plasma gonadotrophins,
Halle J.S.; Smidt G.L.: O’Dwyer K.D.; Lin S.-Y. PHYS. THER. 1990 70/l I (690-699) The purpose of the study was to determine the relationship between trunk muscle strength and bone mineral density (BMD). Fifty-six postmenopausal women, aged 38 to 73 years, were examined. The BMD of lumbar vertebrae L24, the femoral neck, the Ward’s triangle, and the greater trochanter was measured with dual-photon absorptiometry. Isometric and isokinetic torque and work measurements obtained on a trunk testing unit were used to assess trunk flexor and extensor strength. Correlation analysis demonstrated a statistically significant relationship between most trunk torque and work measurements and BMD. The trunk extensors generally provided higher correlations with BMD than did the trunk flexors, and the isokinetic extension torque values demonstrated higher correlations than the isometric extension values in every case. Linear backward-regression models, based on the subjects’ weight and trunk flexor and extensor torque and work measurements, demonstrated multiple-correlation coefficients of .67, S8, .43, and .65 in predicting the BMD of the L24 region, femoral neck, Ward’s triangle, and greater trochanter region. respectively. Estrogen therapy status did not affect the linear regression models. These data suggest a positive relationship in postmenopausal women between flexor and extensor torque values and BMD at the lower lumbar spine and proximal femur. [Halle JS, Smidt GL. O’Dwyer KD, Lin S-Y. Relationship between trunk muscle torque and bone mineral content of the lumbar spine and hip in healthy postmenopausal women.
90365401 Selective depression of metabolic activities in cortical osteoblasts at the site of femoral neck fractures
Dodds R.A.; Emery R.J.H.; Klenerman L.: Chayen J.; Bitensky L. Division of Cellular Biology,
The Kennedy Institute of Rheumatology,
Bute Gardens, London, W6 70 W
BONE 1990 I l/3 (157-161) The aim of this investigation was to determine whether some metabolic defect might be related to the propensity of osteoporotic femoral necks to fracture acutely. To this end, the activities of two dehydrogenases of the glycolytic Embden-Meyerhof pathway, two of the pentose phosphate pathway, two mitochondrial enzymes, and alkaline phosphatase were measured in the cortical and in the trabecular osteoblasts. Comparison was made with such activities in iliac crest biopsies from patients with these fractures and from the equivalent femoral and iliac crest samples from patients with osteoarthritis of the hip, in biopsies from the iliac crests from seven patients with no bony abnormality, and in specimens from the fracture site of six traumatic fractures. The results showed a highly significant decrease in the activities of the two enzymes of the pentose phosphate pathway (p < 0.001) in the cortical, but not in the trabecular, osteoblasts in the osteoporotic fractures. This could not be attributed to the trauma of acute fracture since it was not found in traumatic fractures. Other experimental evidence has indicated that a relationship may occur between depressed activity of these enzymes and a retardation of bone formation.
90365515 Transdermal estradiol. A review of ib pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of menopausal complaints
Balfour J.A.; Heel R.C. Adis Drug Information
Services, Adis International
Ltd., 41 Centorian Drive, Auckland
DRUGS 1990 40/4 (561-582) The estradiol transdermal therapeutic system is a cutaneous delivery device which delivers estradiol into the systemic circulation via the stratum corneum at a constant rate for up to 4 days. Physiological levels of estradiol (the major estrogen secreted by the ovaries in premenopausal women) can therefore be maintained in postmenopausal women with low daily doses because first-pass hepatic metabolism is avoided. In short term clinical studies, the beneficial effects of transdermal estradiol on plasma gonadotrophins,