91 – Insulin resistance and lipid levels in adolescent subjects who later develop psychosis

ABSTRACTS / Schizophrenia Research 98 (2008) 3–199 (21%). Participant characteristics were: mean age 44.5 years (SD = 12.2), 57% female, 55% Caucasian, 19% African American and 6% Hispanic. Screening results indicated substantial elevations in metabolic risks (fasting sample): 51% had metabolic syndrome, 81% were overweight/obese (BMI ≥25), 35% had elevated total cholesterol (TCHOL ≥200 mg/dL), 59% had suboptimal HDL (≤40 mg/dL), 45% had elevated triglycerides (TG ≥150 mg/dL), 45% had an elevated TC/HDL ratio (N4.5), 12% had elevated fasting glucose (≥126 mg/dL), and 31% were hypertensive (≥140/90 mmHg). Up to 61% of patients with metabolic syndrome were not receiving any treatment for the health risk. Conclusions: The prevalence of weight, lipid and glucose abnormalities in patients with schizophrenia and bipolar disorder was substantial and frequently untreated or undertreated in this national mental health clinic screening program. doi:10.1016/j.schres.2007.12.157

91 – INSULIN RESISTANCE AND LIPID LEVELS IN ADOLESCENT SUBJECTS WHO LATER DEVELOP PSYCHOSIS H. Koponen 1, J. Vuononvirta 2, P. Mäki 2, H. Halonen 2, J. Miettunen 2, I. Moilanen 3, A. Taanila 4, A. Ruokonen 5, J. Veijola 2.

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92 – PARENTAL AGE DISPARITY – IS IT A FACTOR TO BE CONSIDERED IN THE GENESIS OF MENTAL ILLNESS? S. Krishnaswamy 1, K. Subramaniam 1. 1 Department of Psychiatry, Faculty of Medicine, Penang Medical College, Penang, Malaysia

Presenting Author details: [email protected] No. 4, Jalan Sepoy Lines, 10450 Penang, Malaysia, Tel.: +60 04 2263459; fax: +60 04 2274308. Background: Older and younger fathers have been associated with higher risk for schizophrenia in the progenies. This paper aims to examine the issues concerning paternal age disparity and extreme paternal age associated with common mental disorders in the progenies. Methods: As study involving 3666 subjects selected by stratified random sampling in Malaysia, was planned to elicit risk factors and prevalence of psychiatric morbidity. Using logistic regression analysis the odds ratios were determined for parental age disparity in common mental disorders. Results: Those with paternal age at birth below 19 and 50–59 had 2.5 times and 4.7 times higher risk for mental illness. Conclusions: Examines factors contributing to paternal disparity, older and younger fathers and various strengths and weaknesses of the study.

1

Department of Psychiatry, University of Kuopio, Finland Department of Psychiatry, University of Oulu, Finland 3 Department of Child Psychiatry, University of Oulu, Finland 4 Department of Public Health Science and General Practice, University of Oulu, Finland 5 Department of Clinical Chemistry, University of Oulu, Finland 2

Presenting Author details: hannujuhani.koponen@ uku.fi P.O. Box 1777, FIN-70211 Kuopio, Finland, Tel.: +358 40 550 5996. Background: The aim of the study was to investigate the levels of fasting blood glucose, insulin and lipids and the prevalence of insulin resistance in adolescents who later develop a psychotic episode. Methods: The study population, the Northern Finland 1986 Birth Cohort, originally consists of 9432 children born alive in the two northernmost provinces in Finland. At the age of 15 to 16, 5748 cohort members participated in medical examination including the measurements of body height, weight and waist circumference, blood glucose, lipid and insulin levels and insulin resistance. The Finnish Hospital Discharge Register was used to find the participants who after the follow-up visit developed psychosis, between 2002 and 2005. Psychiatric hospitalization for a non-organic psychosis was found in 17 cases and their results were compared with other members (N = 5731) without a history of psychosis. Results: There were no differences in the waist circumference, blood glucose, serum insulin, cholesterol and triglyceride levels, or insulin resistance between the study groups. Conclusions: Our results suggest that later psychotic episode is not preceded by disturbances of glucose and lipid metabolism. Acknowledgement: This work was supported by grants from the Finnish Academy (no. 113 760, HJK; and 214 273, JV). doi:10.1016/j.schres.2007.12.158

doi:10.1016/j.schres.2007.12.159

93 – THE PROPENSITY TO SUBSTANCE ABUSE IN BIPOLAR DISORDER T.V. Lagerberg 1, P.A. Ringen 2, A.O. Berg 2, S. Larsson 3, K.S. Sundet 4, O.A. Andreassen 1,2, I. Melle 1,2. 1

Ulleval University Hospital, Norway Institute of Psychiatry, University of Oslo, Norway 3 Aker University Hospital, Norway 4 Institute of Psychology, University of Oslo, Norway 2

Presenting Author details: [email protected] Kirkeveien 144, 0407 Oslo, Norway, Tel.: +47 99 020335; fax: +47 23 027351. Background: The prevalence of substance use disorders (SUD) in bipolar disorder (BPD) is high. Whether BPD subjects without SUD also use more substances than healthy subjects is still unclear. Aims: Investigate the rates of SUDs and subthreshold abuse in BPD I and II and differences between the two groups. Study if age at onset of BPD differs between subjects using alcohol versus cannabis and if a younger age at onset increases susceptibility to substance abuse. Methods: Adult patients with BPD I and II (SCID-I) were examined regarding type and frequency of substance use in defined age intervals and lifetime. Results: Preliminary analyses based on the first 40 BPD I, 46 BPD II patients indicated that 31% had at least one lifetime SUD, while 19% had subthreshold abuse of alcohol/drugs. A total of 76% had ever tried drugs. There was a trend towards more use of solely