92207039 Correlation of cervical cytology and human papillomavirus DNA detection is postmenopausal women

84 Objective - To estimate the response rates and operating costs of three recruitment methods within a regional osteoporosis screening programme. Design - Randomised trial of three types of invitation letter: one offering fixed appointments with option to change time, one offering fixed appointments but requiring telephoned confirmation of intention to attend, and one inviting recipient to telephone to make an appointment. Setting - Osteoporosis screening unit, Aberdeen. Subjects - 1200 women aged 45-49 years living within 32 km of Aberdeen and randomly selected from the community health index. 400 women were random&d to each appointment method. Main outcome measures - Numbers attending for screening; default rate among women who confirmed appointments; social class of attenders; cost per appointment slot and per completed scan. Results - 299 (75%), 277 (69%) and 217 (54%) women were scanned after fixed, confirmable, and open invitations respectively. Women who attended were given a questionnaire, and 694 (87.5%) returned it. No significant differences were found in the social class of attenders among the three methods. Of the 514 women who made or confirmed appointments, 494 attended for a scan. Total costs per scan were 25.00, 21.40, and 21.00 for fixed, confirmable, and open invitations respectively. Conclusions - The offer of a fixed appointment requiring telephoned confirmation has the potential to reduce the costs of scanning without exaggerating any social bias or significantly reducing response rates provided that empty appointments can be rebooked at short notice. 92207039 Correlation of cervical cytology and human papillomavirus DNA detection in postmenopausal women Symmans F.; Mechanic L.; MacConnell P.; DaSilva K.; Stricker B.; Nuovo G.J. Department of Pathology, SUNY, Stony Brook, NY Ii794

INT. J. GYNECOL. PATHOL. 1992 11/3 (204-209) This study correlated the cytological features of cervical swabs from postmenopausal women with the histological findings and the detection of human papillomavirus (HPV) using filter hybridization analysis. Of 17 postmenopausal women seen at colposcopy for an abnormal Papanicolaou (Pap) smear, most often squamous atypia, HPV DNA was detected in one (6%) cervical swab. Biopsy-proven cervical squamous intraepithelial lesions (SILs) were noted in two of the 17 (12%). The HPV DNA detection rate was equivalent to that found in 47 postmenopausal women who had hysterectomies for noncervical disease. The rates of HPV detection and biopsy-proven SIL in premenopausal women seen at colposcopy was 55% and 66%, respectively. The HPV DNA detection rate for postmenopausal women with biopsy-proven SILs as determined by in situ hybridization was 19/26 (73%), which is equivalent to the rate in premenopausal women. It is concluded that squamous atypia in postmenopausal women is rarely associated with either biopsy-proven SIL or HPV DNA detection and thus, in many cases, may represent atrophic changes. 92208129 Effect of menopawx and hormone replacement therapy w urinary excretion of pyridiniam cra4inks:

A

10ngitndiMl aDd cross9eetioMl study

Hassager C.; Colwell A.; Assiri A.M.A.; Eastell R.; Russell R.G.G.; Christiansen C. Department of Clinical Chemistry, Giostrup Hospital, University of Copenhagen, DK-2600 Glostrup

CLIN. ENDOCRINOL.

1992 37/l (45-50)

Objective - To study longitudinally the effect of the menopause and hormone replacement therapy on the new markers of bone resorption: urinary excretion of pyridinohne and deoxypyridinoline. Design and patients - Urinary pyridinoline and deoxypyridinoline were measured every 3 months for 2-3 years in 15 healthy women aged 45-54 years. Nine remained premenopausal and six became post-menopausal during the study. Urinary pyridinoline and deoxypyridinohne were also measured before and after 3 months of either placebo or hormone replacement therapy in 65 post-menopausal women, aged 45-54 years, who were participating in a double-blind study. Measurements - Urinary pyridinoline and deoxypyridinoline were measured in fasting urine samples by spectrofluorometry after high performance liquid chromatography and corrected for creatinine excretion. Results - Urinary pyridinohne and deoxypyridinoline remained almost constant during the premenopausal period. Both started to increase 6 months after the last menstrual bleeding and the mean post-menopausal values were 30-500/o higher than the premenopausal values in the same subjects (values in nmolAmno1 creatinine given as mean f SEM: