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932. Proton Brain GABA and Suicidal Behavior in Veterans
Biological Psychiatry
Saturday Abstracts
frontal gyrus (SFG), bilateral putamen, right mid-cingulate, and left posterior cingulate cortex (PCC). Group responses did not differ during or after the breathing load. Increased anticipatory putamen activation was associated with greater reward dependence, and anticipatory activation in SFG, putamen, and PCC was inversely associated with months of bulimic symptom remission. Conclusions: Hyperactivation during the expectation of an aversive interoceptive experience could represent an exaggerated prediction error signal. This signal may sensitize individuals to changes in interoceptive state and could contribute to or result from repeated binge-eating/purge episodes. Conceptualizing BN as a disorder of aversive interoceptive instability may inform new interventions targeted at regulating interoceptive experiences. Supported By: R01 MH042984; The Price Foundation Keywords: Interoception, Bulimia Nervosa, fMRI
931. More Efficient Brain Connectivity Network in Veterans with Suicide Attempt Jaeuk Hwang1, Margaret Legarreta2, Charles Elliott Bueler3, Jennifer DiMuzio3, Erin McGlade3, and Deborah Yurgelun-Todd3 1 Diagnostic Neuroimaging, University of Utah, 2MIRECC, Department of Veterans Affairs, 3Diagnostic Neuroimaging, University of Utah
Background: Suicide is a public health concern for United State veterans and civilians. Prior research has shown neurobiological factors in suicide; however, studies of neuroimaging correlates of suicide risk have been limited. The current study applied complex weighted network analyses to characterize the neural connectivity in white matter in veterans with suicide behavior. Methods: Eighty veterans (64 males, 16 females) with a mean age of 36.9 years completed diffusion tensor imaging and a clinical battery including the Columbia Suicide Severity Rating Scale (C-SSRS). Participants included 28 veterans without suicidal behavior, 29 with only suicidal ideation, and 23 with suicide attempt. Structural connectivity networks among 82 parcellated regions were produced using whole-brain tractography. Global and nodal metrics of network topology including efficiency and nodal degree were calculated among three groups. Results: Veterans with a history of suicide attempt had shorter characteristic path length and greater global efficiency and mean weighted degree of global network metrics (p , 0.024). Suicide attempters had sixteen hubs among 82 cerebral nodes, whereas the no suicide and suicide ideation groups had 12 hubs. Moreover, the left posterior cingulate cortex showed significantly greater weighted degree in veterans with suicide attempt relative to others (p,0.0003). Conclusions: Veterans with suicide attempt had more efficient connectivity networks and more hub regions in the brain; these findings may be distinctive neurobiological markers for individuals with suicide attempt. Strong connectivity in the left posterior cingulate cortex may be implicated in traumatic autobiographic memory recall in veterans with suicide attempt.
Supported By: Military Suicide Research Consortium (MSRC) Keywords: Suicide, Diffusion Tensor Imaging (DTI), Veterans, Brain networks, Brain connectivity
932. Proton Brain GABA and Suicidal Behavior in Veterans Chandni Sheth1, Erin McGlade2, Andy Prescott3, Perry Renshaw2, and Deborah Yurgelun-Todd2 University of Utah Medical School, Brain Institute, 2Diagnostic Neuroimaging, University of Utah, Department of Psychiatry, University of Utah, Department of Veteran Affairs, Rocky Mountain MIRECC, 3Diagnostic Neuroimaging, University of Utah, Department of Radiology, University of Utah 1
Background: Studies investigating the neurobiological correlates of suicidal behavior have not provided conclusive results; thus, examinations of changes in neurochemistry that correspond with suicidal behaviors (SB) are limited. Although men have a higher rate of suicide completion, partly due to more violent methods, and women have a higher rate of suicide attempts, sex differences in the neurobiological underpinnings of suicide are not well understood. The current study evaluated the relationship between brain chemistry in the anterior cingulate cortex (ACC), a brain region implicated in suicide, and suicide behavior in female compared to male veterans. Methods: Eighty-one veterans (16 females, mean age537.15 years) were scanned on a 3T Siemens VerioTM whole-body MRI scanner. MRS data were acquired from the voxels positioned bilaterally within the ACC. MRS neurochemical profiling included analysis of creatine (Cre), N-acetyl aspartate, and GABA. Participants also completed a clinical battery including the Columbia Suicide Severity Rating Scale (C-SSRS). Results: Female veterans with SB showed lower GABA/Cre (p50.04) compared to female veterans with no SB. Furthermore, HAM-A scores negatively correlated with GABA/Cre (p50.02) in female veterans but not in male veterans. Conclusions: These preliminary data suggest altered neurochemistry in female veterans with a history of suicidal behavior and highlight sex-specific metabolite changes. In agreement, previous studies showed reduced expression of GABA-A receptors in suicide decendents; collectively suggesting that dysfunction in GABAergic transmission may contribute to SB, especially in females. Replication of these results would suggest specific treatment approaches targeted at females compared to males. Supported By: Military Suicide Risk Consortium & Salt Lake City MIRECC Keywords: Suicide, Proton Magnetic Resonance Spectroscopy, GABA
933. Entropy Analysis Shows Temporal Pole Diffusivity Changes in Bipolar Disorder Karl Spuhler, Christine DeLorenzo, Ramin Parsey, and Chuan Huang Stony Brook University School of Medicine
Biological Psychiatry May 15, 2017; 81:S277–S413 www.sobp.org/journal
S377
Saturday Abstracts
frontal gyrus (SFG), bilateral putamen, right mid-cingulate, and left posterior cingulate cortex (PCC). Group responses did not differ during or after the breathing load. Increased anticipatory putamen activation was associated with greater reward dependence, and anticipatory activation in SFG, putamen, and PCC was inversely associated with months of bulimic symptom remission. Conclusions: Hyperactivation during the expectation of an aversive interoceptive experience could represent an exaggerated prediction error signal. This signal may sensitize individuals to changes in interoceptive state and could contribute to or result from repeated binge-eating/purge episodes. Conceptualizing BN as a disorder of aversive interoceptive instability may inform new interventions targeted at regulating interoceptive experiences. Supported By: R01 MH042984; The Price Foundation Keywords: Interoception, Bulimia Nervosa, fMRI
931. More Efficient Brain Connectivity Network in Veterans with Suicide Attempt Jaeuk Hwang1, Margaret Legarreta2, Charles Elliott Bueler3, Jennifer DiMuzio3, Erin McGlade3, and Deborah Yurgelun-Todd3 1 Diagnostic Neuroimaging, University of Utah, 2MIRECC, Department of Veterans Affairs, 3Diagnostic Neuroimaging, University of Utah
Background: Suicide is a public health concern for United State veterans and civilians. Prior research has shown neurobiological factors in suicide; however, studies of neuroimaging correlates of suicide risk have been limited. The current study applied complex weighted network analyses to characterize the neural connectivity in white matter in veterans with suicide behavior. Methods: Eighty veterans (64 males, 16 females) with a mean age of 36.9 years completed diffusion tensor imaging and a clinical battery including the Columbia Suicide Severity Rating Scale (C-SSRS). Participants included 28 veterans without suicidal behavior, 29 with only suicidal ideation, and 23 with suicide attempt. Structural connectivity networks among 82 parcellated regions were produced using whole-brain tractography. Global and nodal metrics of network topology including efficiency and nodal degree were calculated among three groups. Results: Veterans with a history of suicide attempt had shorter characteristic path length and greater global efficiency and mean weighted degree of global network metrics (p , 0.024). Suicide attempters had sixteen hubs among 82 cerebral nodes, whereas the no suicide and suicide ideation groups had 12 hubs. Moreover, the left posterior cingulate cortex showed significantly greater weighted degree in veterans with suicide attempt relative to others (p,0.0003). Conclusions: Veterans with suicide attempt had more efficient connectivity networks and more hub regions in the brain; these findings may be distinctive neurobiological markers for individuals with suicide attempt. Strong connectivity in the left posterior cingulate cortex may be implicated in traumatic autobiographic memory recall in veterans with suicide attempt.
Supported By: Military Suicide Research Consortium (MSRC) Keywords: Suicide, Diffusion Tensor Imaging (DTI), Veterans, Brain networks, Brain connectivity
932. Proton Brain GABA and Suicidal Behavior in Veterans Chandni Sheth1, Erin McGlade2, Andy Prescott3, Perry Renshaw2, and Deborah Yurgelun-Todd2 University of Utah Medical School, Brain Institute, 2Diagnostic Neuroimaging, University of Utah, Department of Psychiatry, University of Utah, Department of Veteran Affairs, Rocky Mountain MIRECC, 3Diagnostic Neuroimaging, University of Utah, Department of Radiology, University of Utah 1
Background: Studies investigating the neurobiological correlates of suicidal behavior have not provided conclusive results; thus, examinations of changes in neurochemistry that correspond with suicidal behaviors (SB) are limited. Although men have a higher rate of suicide completion, partly due to more violent methods, and women have a higher rate of suicide attempts, sex differences in the neurobiological underpinnings of suicide are not well understood. The current study evaluated the relationship between brain chemistry in the anterior cingulate cortex (ACC), a brain region implicated in suicide, and suicide behavior in female compared to male veterans. Methods: Eighty-one veterans (16 females, mean age537.15 years) were scanned on a 3T Siemens VerioTM whole-body MRI scanner. MRS data were acquired from the voxels positioned bilaterally within the ACC. MRS neurochemical profiling included analysis of creatine (Cre), N-acetyl aspartate, and GABA. Participants also completed a clinical battery including the Columbia Suicide Severity Rating Scale (C-SSRS). Results: Female veterans with SB showed lower GABA/Cre (p50.04) compared to female veterans with no SB. Furthermore, HAM-A scores negatively correlated with GABA/Cre (p50.02) in female veterans but not in male veterans. Conclusions: These preliminary data suggest altered neurochemistry in female veterans with a history of suicidal behavior and highlight sex-specific metabolite changes. In agreement, previous studies showed reduced expression of GABA-A receptors in suicide decendents; collectively suggesting that dysfunction in GABAergic transmission may contribute to SB, especially in females. Replication of these results would suggest specific treatment approaches targeted at females compared to males. Supported By: Military Suicide Risk Consortium & Salt Lake City MIRECC Keywords: Suicide, Proton Magnetic Resonance Spectroscopy, GABA
933. Entropy Analysis Shows Temporal Pole Diffusivity Changes in Bipolar Disorder Karl Spuhler, Christine DeLorenzo, Ramin Parsey, and Chuan Huang Stony Brook University School of Medicine
Biological Psychiatry May 15, 2017; 81:S277–S413 www.sobp.org/journal
S377