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93P CLINICORADIOGRAPHIC CHARACTERISTICS OF ENDOBRONCHIAL LIPOMAS
S42 wall. Histologic examination found 17 (89.4%) cases with malignant tumor signs, 2 (10.5%) with benign tumors. Postoperative period was uneventful to 5 (31%) patients. Level of intrahospital mortality was 10.5% (2 cases of extended pneumonectomy among them 1 intraoperative death case). Reasons of death were thromboemboly of arteria pulmonalis and cardial insufficiency. 3 (15.7%) pts had appeared massive metastasis signs to postoperative period. In spite of intensive chemo- and radiotherapy nobody with malignant process survived 2 years after operation. Pts with benign tumors did well. Conclusions: Our results indicate HAP as rare asymptomatic and very aggressive tumor. Performance of radical tumor resection is the attempt of successful treatment HAP. Pts with malignant processes have poor prognosis. 93P CLINICORADIOGRAPHIC CHARACTERISTICS OF ENDOBRONCHIAL LIPOMAS B.A. Milenkovic1 , J.M. Stojˇsi´ c2 , R. Stevic3 , A.M. Dudvarski1 1 Institute for Pulmonary Diseases and TB, Clinical Centre of Serbia, Belgrade, Serbia, 2 Oncology Department, Institute of Lung Diseases and Tuberculosis, Belgrade, Serbia, 3 Institute for Radiology, Clinical Centre of Serbia, Belgrade, Serbia Background: Lung lipoma is an extremely rare benign tumor. The endobronchial lipomas (EL) are more common than parenchymal lipomas. Chest x-ray and CT may play a role in the diagnosis but the definitive diagnosis requires tissue examination. The aim of the study was to describe the clinical and radiological features of EL. Methods: We have analyzed medical records from 9 cases of EL. Results: Nine patients (pts) with EL were included in this study (5 male and 4 female; mean age, 61 years). Lipomas did not show a preference for one hemithorax (4 in the right bronchi and 3 in the left bronchi). All tumors were found to arise in the submucosal layer of the main or lobar bronchus. All pts were smokers and symptomatic, and their symptoms included cough (100%), hemoptysis (18.2%%), elevated temperature (44.1%), and chest pain (100%). These symptoms were present for 1 month to 2 years (mean = 4 months). Abnormal radiographic findings (chest x-ray and CT) were reported in all pts: 6 (66.6%) had atelectasis, 3 (33.3%) had consolidation, but no mass shadow nor pleural effusion. Pulmonary function tests showed a normal ventilation in 6 (66.6%) pts and a mild restrictive ventilatory pattern in 3 (33.3%) pts. Endoscopically, the tumor appeared as a reddish (52.9%) or yellowish (47.1%) mass. The definitive diagnosis required tissue examination which was obtained by bronchoscopy. Lung lipomas were diagnosed preoperatively in all pts and no lung cancer accompanied lipoma. Surgical treatment, has been performed in all pts because of destructive peripheral lung disease and the clinical suspicion of malignancy. Surgical procedures were performed with maximum preservation of residual lung function: 5 lobectomies and 4 resections by bronchotomy. Conclusions: EL caused severe parenchymal damage due to bronchus obstruction. The diagnosis was strongly suggested by the radiographic, CT and bronchoscopic findings, although the definitive diagnosis required tissue examination. Surgical therapy was indicated for those pts who had destructive peripheral lung disease. 94P ACTIVE PULMONARY TUBERCULOSIS IN LUNG CANCER PATIENTS ˇ.B. Uskokovi´ T.N. Adˇzi´ c, J.M. Stojˇsi´ c, Z c-Stefanovi´ c, M.M. Savi´ c, G.D. Radosavljevi´ c-Aˇsi´ c Oncology Department, Institute of Lung Diseases and Tuberculosis, Belgrade, Serbia Background: Lung cancer (LC) might be associated or masked by pulmonary tuberculosis (PTB). The aim of the study was to desrcibe
Screening, diagnosis and staging the clinical characteristics of patients (pts) with coexisting LC and PTB. Methods: We retrospectively reviewed the medical records of LC pts and PTB during three years period 2006 2008 at the University Hospital in Belgrade. There were 12 PTB pts among 5130 lung cancer diagnosed, two female with average age of 58 years and ten male with average age of 53 years. Results: NSCLC was diagnosed in 10 (83%) pts, adenocarcinoma and squamous-cell carcinoma in five pts each, while SCLC was diagnosed in two (17%) pts. Tumor shadow and TB were presented in the same lobe in 5 (42%) pts. Among the NSCLC pts, 7 (58%) were with stage IIIB: six with T4N2MO and one with T4N3MO. Other three NSCLC pts left were with IB, IIB, and IIIA stage of LC. Acid Fast Bacilli (AFB) were found in 9 (75%) pts, while L¨ owenstein Jensen cultures were positive in all 12 pts. Antituberculous drugs were applied in standardized doses. Chemotherapy based on Platinum regimen was performed in 6 (50%) pts, combined chemo and radiotherapy in 3 (25%), and the best supportive care (BSC) in 3 (25%) pts. One patient underwent surgery with resectio trachea and terminoterminal anastomosis, and other one was repeatly treated with argon plasma coagulation (APC). Conclusions: The majority of our patients were at advanced stage of LC. In the management of LC, physicians should consider the possibility of coexisting PTB. 95 PATTERN, OUTCOMES AND SURVIVAL ANALYSIS OF BRONCHOGENIC CARCINOMA IN A DEVELOPING COUNTRY M. Marappan The Lung Cancer Clinic, DD Hospital & Research Centre, Chennai, India Background: Lung cancer is a significant cause of mortality even in developed countries. Additional strategies for early detection of lung cancer should be considered, as therapy results in early stage of lung malignancies are significantly better and overall and disease free survival have been improved recently. Aim of our study is to find out pattern, outcomes and survival after diagnosis of bronchogenic carcinoma at the lung cancer clinic in a developing country using currently available treatment regimens. Also we aim to find out factors which predict favorable/unfavorable survival. Methods: In a prospective observational study with 89 cases of histologically proved bronchogenic carcinoma, 81 patients were underwent to chemo- or radiotherapy or combination therapy. Factors like age, sex, comorbidities, smoking, histological type and staging were assesed. Patients with other malignancies and malignant pleural effusion with no definitive evidence of lung cancer were excluded. Results: Out of 89 patients, 63 were males, 60 of them above 60 years, and 56 of them were smokers. The average duration of illness at the time of diagnosis was 4 months. Adenocarcinoma was represented with 41% and squamous cell carcinomas in 33%. According TNM stage, 52% were presented with stage IIIA and 24% at the stage IIIB. One-year survival rate was 34% and 2-years 19%. Staging, cell type and age were found to be significant factors in survival prediction. Conclusions: Survival time after diagnosis and its correlation with factors like histological type and staging, age, sex and smoking status definitely have influence on outcome. Knowledge about these factors will help in intervening at early stage.
Screening, diagnosis and staging the clinical characteristics of patients (pts) with coexisting LC and PTB. Methods: We retrospectively reviewed the medical records of LC pts and PTB during three years period 2006 2008 at the University Hospital in Belgrade. There were 12 PTB pts among 5130 lung cancer diagnosed, two female with average age of 58 years and ten male with average age of 53 years. Results: NSCLC was diagnosed in 10 (83%) pts, adenocarcinoma and squamous-cell carcinoma in five pts each, while SCLC was diagnosed in two (17%) pts. Tumor shadow and TB were presented in the same lobe in 5 (42%) pts. Among the NSCLC pts, 7 (58%) were with stage IIIB: six with T4N2MO and one with T4N3MO. Other three NSCLC pts left were with IB, IIB, and IIIA stage of LC. Acid Fast Bacilli (AFB) were found in 9 (75%) pts, while L¨ owenstein Jensen cultures were positive in all 12 pts. Antituberculous drugs were applied in standardized doses. Chemotherapy based on Platinum regimen was performed in 6 (50%) pts, combined chemo and radiotherapy in 3 (25%), and the best supportive care (BSC) in 3 (25%) pts. One patient underwent surgery with resectio trachea and terminoterminal anastomosis, and other one was repeatly treated with argon plasma coagulation (APC). Conclusions: The majority of our patients were at advanced stage of LC. In the management of LC, physicians should consider the possibility of coexisting PTB. 95 PATTERN, OUTCOMES AND SURVIVAL ANALYSIS OF BRONCHOGENIC CARCINOMA IN A DEVELOPING COUNTRY M. Marappan The Lung Cancer Clinic, DD Hospital & Research Centre, Chennai, India Background: Lung cancer is a significant cause of mortality even in developed countries. Additional strategies for early detection of lung cancer should be considered, as therapy results in early stage of lung malignancies are significantly better and overall and disease free survival have been improved recently. Aim of our study is to find out pattern, outcomes and survival after diagnosis of bronchogenic carcinoma at the lung cancer clinic in a developing country using currently available treatment regimens. Also we aim to find out factors which predict favorable/unfavorable survival. Methods: In a prospective observational study with 89 cases of histologically proved bronchogenic carcinoma, 81 patients were underwent to chemo- or radiotherapy or combination therapy. Factors like age, sex, comorbidities, smoking, histological type and staging were assesed. Patients with other malignancies and malignant pleural effusion with no definitive evidence of lung cancer were excluded. Results: Out of 89 patients, 63 were males, 60 of them above 60 years, and 56 of them were smokers. The average duration of illness at the time of diagnosis was 4 months. Adenocarcinoma was represented with 41% and squamous cell carcinomas in 33%. According TNM stage, 52% were presented with stage IIIA and 24% at the stage IIIB. One-year survival rate was 34% and 2-years 19%. Staging, cell type and age were found to be significant factors in survival prediction. Conclusions: Survival time after diagnosis and its correlation with factors like histological type and staging, age, sex and smoking status definitely have influence on outcome. Knowledge about these factors will help in intervening at early stage.