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94097698 Diagnostic role of follicle-stimulating hormone (FSH) measurements during the menopausal transition — An analysis of FSH, oestradiol and inhibin
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Abstract section / Maruritas 20 (1994) 221-224
r = +O.I I, p < 0.05). These associations between dental status and BMD support the hypothesis that systemic bone loss may contribute to tooth loss.
94097698 Diagnostic role of follicle-stimulating hormone (FSH) measurements during the menopausal transition - An analysis of FSH, oestradiol and inhibin Burger H.G.
94112995 Mechanism of calcification in atherosclerosis Demer L.L.; Watson K.E.; Bostrom K. Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90024-1679 TRENDS CARDIOVASC. MED. 1994 4/l (45-49) Calcification is commonly associated with atherosclerosis, and it has important clinical implications, especially in coronary arteries. The mineral has been identified as the same mineral as in bone, hydroxyapatite, and several features of its development suggest a mechanism similar to osteogenesis and not merely passive precipitation. The artery wall has been shown to contain several bone-related proteins, including those for osteopontin, osteonectin, and osteocalcin, as well as proteoglycan core proteins homologous with bone biglycan. Our laboratory recently demonstrated that a potent osteogenic differentiation factor, bone morphogenetic protein 2a, is expressed in calcitied human atherosclerotic lesions, suggesting that arterial calcification may be initiated by an osteogenic differentiation. In addition, a cell capable of calcium mineral formation in vitro has been isolated from bovine and human aorta and identified by immunostaining as having a surface marker characteristic of microvascular pericytes. These findings suggest the possibility that plaque calcification develops when a signal from atherosclerotic plaque or a factor associated with atherosclerosis induces expression of bone morphogenetic protein, leading to osteogenic differentiation of pluripotential, pericytelike cells located in the arterial intima, which then produce bonelike matrix and hydroxyapatite mineral. These fmdings also raise questions as to whether osteogenic-promoting factors used to prevent osteoporosis may also increase risk of arterial calcification.
Prince Henry’s Medical Res. Inst.. PO Box 152. Clayton. Vie. 3168 EUR. J. ENDOCRINOL. 1994 130/I (38-42) This review examines the role of follicle-stimulating hormone (FSH) measurement in assessing the significance of symptoms and possible continuing fertility during the menopausal transition. Follicle-stimulating hormone measurement is advocated frequently as a useful diagnostic tool in perimenopausal patients. Several investigators have shown that the serum FSH level increases in the early-midfollicular and early postovulatory phases in women over the age of 40 years who continue to experience regular menstrual cycles. The serum oestradiol level
94116566
94106829 A clinical study on memory function in climacteric and periclimacteric women Ohkura T.; lsse K.; Watabe H.; Segawa Y.; Mitsuya K.; Enomoto H.; Hayashi M.; Yaoi Y. Department of Psychiatry, TMTGH, Tokyo ACTA OBSTET. GYNAECOL. JPN. 1994 46/3 (271-276) This study was designed to investigate memory function in
Safety of hormone replacement therapy (HRT) in systemic lupus erythematosos (SLE) Arden N.K.; Lloyd M.E.; Spector T.D.; Hughes G.R.V. Department o$ Rheumatology, St Thomas’ Hospital, London LUPUS 1994 311 (11-13) Despite its obvious benefits. many physicians are reluctant to prescribe HRT to patients with SLE. We have performed a retrospective study in 60 postmenopausal women with SLE including 30 HRT users and 30 never users. The patients were studied for I2 months after the initiation of HRT. The two groups were well matched for disease characteristics, The HRT users experienced significant improvements in general well being, libido and depression. There was no significant difference in any other parameter measured. There was no increase in the number of thrombo-embolic events in the user group despite 7 patients having a positive thrombophilia screen, In conclusion, in stable postmenopausal SLE HRT appears well tolerated and safe.
may fall (although this is controversial) and the immunoreactive inhibin level falls, being inversely correlated with the rising FSH level. When alterations in menstrual cyclicity or flow commence, signalling the onset of the menopausal transition. FSH levels may change abruptly, rising into the normal postmenopausal range and falling again into the range normally seen in young fertile women. Oestradiol and inhibin generally fluctuate in parallel with each other but inversely to FSH, although at times oestradiol in particular may be increased markedly. Postmenopausal FSH levels may be followed by endocrine evidence compatible with normal ovulation. After the menopause, FSH levels rise IO- I5-fold, with low oestradiol and undetectable inhibin levels. It is concluded that FSH measurement is of little value, if any in the assessment of women during the menopausal transition because it cannot be interpreted reliably and because, apparently, ovulatory (and, presumably. potentially fertile) cycles may occur subsequent to the observation of postmenopausal FSH levels. Both oestradiol and inhibin are important negative feedback regulators circulating FSH.
climacteric and periclimacteric women who lived a normal. ordinary life. Two hundred women treated at the gynecological outpatient clinic of Koshigaya Hospital were divided into 7 groups: groups A(3l-35 yr), B(36-40 yr). C(4l-45 yr). D(46-50 yr), E(5l-55 yr), F(56-60 yr) and G(6l-65 yr). Each group consisted of 30 women except group G(n = 20). The memory function of each group was determined and the mean scores for IO paired hard-associates after three trials of presentation were compared. B were 8.02.0 and statistically different.
The mean scores (SD) for groups A and 8.21.7. respectively. which were not The scores for both groups were
Abstract section / Maruritas 20 (1994) 221-224
r = +O.I I, p < 0.05). These associations between dental status and BMD support the hypothesis that systemic bone loss may contribute to tooth loss.
94097698 Diagnostic role of follicle-stimulating hormone (FSH) measurements during the menopausal transition - An analysis of FSH, oestradiol and inhibin Burger H.G.
94112995 Mechanism of calcification in atherosclerosis Demer L.L.; Watson K.E.; Bostrom K. Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90024-1679 TRENDS CARDIOVASC. MED. 1994 4/l (45-49) Calcification is commonly associated with atherosclerosis, and it has important clinical implications, especially in coronary arteries. The mineral has been identified as the same mineral as in bone, hydroxyapatite, and several features of its development suggest a mechanism similar to osteogenesis and not merely passive precipitation. The artery wall has been shown to contain several bone-related proteins, including those for osteopontin, osteonectin, and osteocalcin, as well as proteoglycan core proteins homologous with bone biglycan. Our laboratory recently demonstrated that a potent osteogenic differentiation factor, bone morphogenetic protein 2a, is expressed in calcitied human atherosclerotic lesions, suggesting that arterial calcification may be initiated by an osteogenic differentiation. In addition, a cell capable of calcium mineral formation in vitro has been isolated from bovine and human aorta and identified by immunostaining as having a surface marker characteristic of microvascular pericytes. These findings suggest the possibility that plaque calcification develops when a signal from atherosclerotic plaque or a factor associated with atherosclerosis induces expression of bone morphogenetic protein, leading to osteogenic differentiation of pluripotential, pericytelike cells located in the arterial intima, which then produce bonelike matrix and hydroxyapatite mineral. These fmdings also raise questions as to whether osteogenic-promoting factors used to prevent osteoporosis may also increase risk of arterial calcification.
Prince Henry’s Medical Res. Inst.. PO Box 152. Clayton. Vie. 3168 EUR. J. ENDOCRINOL. 1994 130/I (38-42) This review examines the role of follicle-stimulating hormone (FSH) measurement in assessing the significance of symptoms and possible continuing fertility during the menopausal transition. Follicle-stimulating hormone measurement is advocated frequently as a useful diagnostic tool in perimenopausal patients. Several investigators have shown that the serum FSH level increases in the early-midfollicular and early postovulatory phases in women over the age of 40 years who continue to experience regular menstrual cycles. The serum oestradiol level
94116566
94106829 A clinical study on memory function in climacteric and periclimacteric women Ohkura T.; lsse K.; Watabe H.; Segawa Y.; Mitsuya K.; Enomoto H.; Hayashi M.; Yaoi Y. Department of Psychiatry, TMTGH, Tokyo ACTA OBSTET. GYNAECOL. JPN. 1994 46/3 (271-276) This study was designed to investigate memory function in
Safety of hormone replacement therapy (HRT) in systemic lupus erythematosos (SLE) Arden N.K.; Lloyd M.E.; Spector T.D.; Hughes G.R.V. Department o$ Rheumatology, St Thomas’ Hospital, London LUPUS 1994 311 (11-13) Despite its obvious benefits. many physicians are reluctant to prescribe HRT to patients with SLE. We have performed a retrospective study in 60 postmenopausal women with SLE including 30 HRT users and 30 never users. The patients were studied for I2 months after the initiation of HRT. The two groups were well matched for disease characteristics, The HRT users experienced significant improvements in general well being, libido and depression. There was no significant difference in any other parameter measured. There was no increase in the number of thrombo-embolic events in the user group despite 7 patients having a positive thrombophilia screen, In conclusion, in stable postmenopausal SLE HRT appears well tolerated and safe.
may fall (although this is controversial) and the immunoreactive inhibin level falls, being inversely correlated with the rising FSH level. When alterations in menstrual cyclicity or flow commence, signalling the onset of the menopausal transition. FSH levels may change abruptly, rising into the normal postmenopausal range and falling again into the range normally seen in young fertile women. Oestradiol and inhibin generally fluctuate in parallel with each other but inversely to FSH, although at times oestradiol in particular may be increased markedly. Postmenopausal FSH levels may be followed by endocrine evidence compatible with normal ovulation. After the menopause, FSH levels rise IO- I5-fold, with low oestradiol and undetectable inhibin levels. It is concluded that FSH measurement is of little value, if any in the assessment of women during the menopausal transition because it cannot be interpreted reliably and because, apparently, ovulatory (and, presumably. potentially fertile) cycles may occur subsequent to the observation of postmenopausal FSH levels. Both oestradiol and inhibin are important negative feedback regulators circulating FSH.
climacteric and periclimacteric women who lived a normal. ordinary life. Two hundred women treated at the gynecological outpatient clinic of Koshigaya Hospital were divided into 7 groups: groups A(3l-35 yr), B(36-40 yr). C(4l-45 yr). D(46-50 yr), E(5l-55 yr), F(56-60 yr) and G(6l-65 yr). Each group consisted of 30 women except group G(n = 20). The memory function of each group was determined and the mean scores for IO paired hard-associates after three trials of presentation were compared. B were 8.02.0 and statistically different.
The mean scores (SD) for groups A and 8.21.7. respectively. which were not The scores for both groups were