959 EFFECT OF BASELINE PROSTATE CANCER RISK ON DUTASTERIDE EFFICACY IN THE REDUCE (REDUCTION BY DUTASTERIDE OF PROSTATE CANCER EVENTS) STUDY

F\VWRVFRSH WKURXJK D GUDLQ WUDFW IROORZLQJ RSHQ VXUJHU\ WR UHPRYH UHVLGXDO FDOFXOL:LWKQHSKURVWRP\GUDLQDJHZHOOHVWDEOLVKHGWKHᚏUVW3&1/ZDVGHVFULEHG LQSDWLHQWVE\)HUQVWURPDQG-RKDQVHQLQ(DUO\ZRUNZDVSLRQHHUHGE\ $ONHQ0DUEHUJHUDQG:LFNKDPLQ(XURSHZLWK&OD\PDQ6PLWKDQG6HJXUDGRLQJ OLNHZLVHLQWKH86$7KHLUZRUNDQGSHUFHSWLYHIRUHVLJKWGHYHORSHGWKHSULQFLSOHV DQGWHFKQLTXHVIRUSHUFXWDQHRXVVWRQHUHPRYDODQGDUHFRQVLGHUHGWKHIRUHIDWKHUV RI WKLV VSHFLDOW\ 7KH WHFKQLTXH JDLQHG LQFUHDVLQJ DSSURYDO LQ WKH ಬV 7KH GHYHORSPHQWRI([WUDFRUSRUHDO6KRFNZDYH/LWKRWULSV\(6:/ DQGLWVZLGHVSUHDG XVHLQWKHPLGಬVOHGWRDUHGXFWLRQLQWKHLQGLFDWLRQVIRU3&1/+RZHYHUDV WKHOLPLWDWLRQVRI(6:/ZHUHUHFRJQLVHGSHUFXDWDQHRXVVXUJHU\RQFHDJDLQURVH LQSRSXODULW\2YHUWKHODVW\HDUVLPSURYHPHQWVLQQHSKURVRFSHVJXLGHZLUHV VWHQWV DQG VWRQH IUDJPHQWDWLRQ GHYLFHV LQFOXGLQJ ODVHUV KDYH OHG WR FRQVWDQW GHYHORSPHQWRIWKHWHFKQLTXHZLWKHYHUZLGHQLQJLQGLFDWLRQVIRULWVXVH Conclusions: 7KHGHYHORSPHQWRI3&1/ZDVGHSHQGDQWRQERWKUDGLRORJLFDODQG XURORJLFDODGYDQFHPHQWV,WLVDJUHDWH[DPSOHRIKRZLPSURYHPHQWVLQVXUJLFDO HTXLSPHQWGHYHORSPHQWRIQHZWHFKQRORJ\LQFUHDVHGXQGHUVWDQGLQJRIXURORJLFDO GLVHDVH DQG WKH FRXUDJH RI SLRQHHU XURORJLVWV DOO FRPELQHG WR SURGXFH D QHZ FRQFHSW RI VXUJLFDO WUHDWPHQW 2QJRLQJ WHFKQRORJLFDO DGYDQFHPHQWV FRQWLQXH WR UHᚏQHWKHWHFKQLTXH

955

PHALLIC DECORATION REPRESENTED IN PALAEOLITHIC ART IN EUROPE 



Introduction & Objectives: 7KHRULJLQRIPDOHJHQLWDOGHFRUDWLRQLVORVWLQWLPH 6LPLODUO\ WKH SULPLWLYH DQWKURSRORJLFDO PHDQLQJ RI JHQLWDO WDWWRR LV XQGHᚏQHG :H DUJXH WKH H[LVWLQJ HYLGHQFH DERXW WKH SUDFWLFH RI PDOH JHQLWDO GHFRUDWLRQ LQ 3UHKLVWRU\ DV UHYHDOHG E\ QXPHURXV DUFKDHRORJLFDO SLHFHV IRXQG LQ GLᚎHUHQW SODFHVLQ(XURSH Material & Methods: :H KDYH VWXGLHG ERWK WKH DUFKDHRORJLFDO DQG DUWLVWLF HYLGHQFH UHJDUGLQJ JHQLWDO PDOH UHSUHVHQWDWLRQV LQ SRUWDEOH DUW SHUIRUPHG LQ (XURSHGXULQJWKH8SSHU3DODHROLWKLFIURPDSSUR[LPDWHO\WR\HDUV EHIRUHSUHVHQW Results: 0DQ\JUDSKLFDOHYLGHQFHVKDYHRXWOLYHGWRRXUGD\VUHYHDOLQJGHFRUDWHG SKDOOL SUREDEO\ ZLWK LQWHQWLRQDO PDUNV RI GHFRUDWLYH SXUSRVH UHFRYHUHG IURP DUFKDHRORJLFDO VLWHV %HVLGHV WKHUH DUH VRPH WHFKQLFDO VLPLODULWLHV EHWZHHQ VRPH GHVLJQV SUHVHQW LQ FDYH ZDOO DUW SRUWDEOH DUW DQG WDWWRR 6RPH RI WKHVH GHVLJQVPD\VWDQGDVWKHDQWKURSRORJLFDORULJLQRIFXUUHQWJHQLWDOWDWWRR,QIDFW ZH NQRZ ERG\ WDWWRR ZDV SUDFWLFHG LQ WKH ᚏQDO SKDVHV RI (XURSHDQ 3UHKLVWRU\ DQG FRXOG KDYH HYHQ EHHQ SUHVHQW PXFK HDUOLHU $UFKDHRORJLFDO HYLGHQFHV UHYHDOGHFRUDWHGSKDOOLFHOHPHQWVZLWKVHULHVRIGRWVDQGOLQHVIURP0DJGDOHQLDQ SHULRGLQRFFLGHQWDO(XURSHDSSUR[LPDWHO\\HDUVDJRIURP*RUJHGಬ(QIHU 'RUGRJQH 0DVGಬ$]LO$ULªJH 5RFGH0DUFDPSV*LURQGH 3ODFDUG&KDUHQWH  )DULQFRXUW+DXWH0DUQH DQG/DXVVHO'RUGRJQH 7KHVHGHVLJQVFRXOGKDYHEHHQ SHUIRUPHGVHYHUDOWKRXVDQG\HDUVHDUOLHULQRULHQWDO(XURSHDW9RJHOKHUG6WHWWHQ  DQG0ª]LQH1RYJRURG6HYHUVN\L ,QJHQHUDOHDUOLHUSKDOOLFUHSUHVHQWDWLRQVDUH DOVR UHDOLVWLF EXW ODFN VR PXFK GHWDLO ,W LV WKHUHIRUH LPSRVVLEOH WR VWDWH WKH UHDO RQVHWRIWKHVHSHFXOLDUGHFRUDWLYHULWXDOV Conclusions: 3KDOOLF GHFRUDWLRQ LQ (XURSHDQ 3DODHROLWKLF DUW LV H[SOLFLWO\ UHSUHVHQWHGLQPDQ\REMHFWVRISRUWDEOHDUWWKDWKDYHRXWOLYHGWRRXUGD\V0DOH JHQLWDOWDWWRRSLHUFLQJDQGVFDULᚏFDWLRQPD\KDYHEHHQSUDFWLFHGDO3DODHROLWKLF WLPHV

THE EVOLUTION OF BLADDER MANAGEMENT IN SPINAL CORD INJURED PATIENTS OVER THE LAST 90 YEARS

%LHUV60*X\3 Duke of Cornwall Spinal Treatment Centre, Dept. of Urology, Salisbury, United Kingdom Introduction & Objectives: 0RUELGLW\DQGPRUWDOLW\GXHWRXURORJLFDOFRPSOLFDWLRQV RI VSLQDO FRUG LQMXU\ 6&,  KDV GUDPDWLFDOO\ UHGXFHG RYHU WKH ODVW  \HDUV :H IROORZ WKH HYROXWLRQ RI LPSURYHG EODGGHU PDQDJHPHQW ZLWK WKH LQWURGXFWLRQ RI FDWKHWHULVDWLRQDQGRWKHUWHFKQLTXHVLQFRQWULEXWLQJWRLPSURYHGRXWFRPHVLQWKLV SDWLHQWJURXS Material & Methods: $VHDUFKRIWKHLQWHUQDWLRQDOOLWHUDWXUHZDVSHUIRUPHGIURP WR6SHFLᚏFDOO\ZHDVVHVVHGWKHHᚑFDF\RIEODGGHUGUDLQDJHRSWLRQVLQ 6&,LQFRQMXQFWLRQZLWKWKHLUUHODWHGFRPSOLFDWLRQVDQGRXWFRPHGDWD Results: ,Q  DQ  PRUWDOLW\ UDWH ZDV UHSRUWHG IURP XULQDU\ LQIHFWLRQ LQ VROGLHUV UHQGHUHG SDUDSOHJLF IURP JXQ VKRW ZRXQGV DV LW ZDV EHOLHYHG WKDW DYRLGLQJ FDWKHWHUL]DWLRQ ZRXOG UHGXFH XULQDU\ LQIHFWLRQ 7KLV FKDQJHG LQ :RUOG :DU ,, :LWK LQFUHDVLQJ QHXURVXUJLFDO H[SHUWLVH EHWWHU IDFLOLWLHV DQG QHZ DQWLELRWLFV ODUJHU QXPEHUV RI VROGLHUV ZLWK 6&, ZHUH HYDFXDWHG IURP WKH ᚏHOG ZLWKDVXSUDSXELFF\VWRVWRP\LQSODFH$OWKRXJKWKHSUHGRPLQDQWFDXVHRIGHDWK UHPDLQHG WKDW RI XURVHSVLV DQG XUDHPLD DERXW  RI 6&, SDWLHQWV HYHQWXDOO\

Eur Urol Suppl 2010;9(2):300

957



$QJXOR-& *DUFLD'LH]0 0DUWLQH]0 1 Hospital Universitario De Getafe. Universidad Europea De Madrid., Dept. of Urology, Getafe (Madrid), Spain, 2Cuevas Prehistóricas De Cantabria, Dept. Prehistory, Cuevas De Monte Castillo (Cantabria), Spain, 3Centre Des Monuments Nationaux, Dept. Prehistory, Grotte De Pair-Non-Pair (Gironde), France

956

VXUYLYHG\HDUV)ROORZXSRIVHUYLFHPHQLQMXUHGLQWKH9LHWQDPFRQᚐLFWUHSRUWHG DGHDWKUDWHRI$OWKRXJKWKLVZDVQRWVLJQLᚏFDQWO\EHWWHUWKDQ:RUOG:DU,,RU WKH.RUHDQ:DURQO\RIGHDWKVUHVXOWHGIURPUHQDOFRPSOLFDWLRQVKDOIWKDW RI WKH SUHYLRXV WZR FRQᚐLFWV 6XFFHVV ZDV DWWULEXWHG WR HDUO\ HᚎHFWLYH EODGGHU PDQDJHPHQW 0RUH UHFHQW VWXGLHV UHSRUW D UHQDOUHODWHG PRUWDOLW\ RI RQO\  6LJQLᚏFDQWFRQWULEXWLRQVWRLPSURYLQJFDUHDOVRFDPHIURPDJUHDWHUUHFRJQLWLRQRI WKHQHXURSDWKLFಯEDGಬಬEODGGHULQLWLDWHGE\+XWFKDQG%XQWVLQWKHFRQFHSW RI RXWᚐRZ UHVLVWDQFH GHYHORSHG LQ WKH ODWH ಬV DQG HDUO\ ಬV E\ 6HDPDQV DQG%XQWVDQGWKHDGYRFDWHGXVHRIHDUO\DQGSURDFWLYHVSKLQFWHURWRP\LQ *XWWPDQQ LQWURGXFHG LQWHUPLWWHQW VWHULOH FDWKHWHUL]DWLRQ LQ  ZKLFK HYROYHG LQWRFOHDQLQWHUPLWWHQWVHOIFDWKHWHUL]DWLRQDQGLVQRZFRQVLGHUHGDJROGVWDQGDUG WUHDWPHQW $GGLWLRQDO EHQHᚏWV ZHUH LQWURGXFHG ZLWK WKH WHFKQLTXHV RI EODGGHU DXJPHQWDWLRQᚏUVWGHVFULEHGE\0LONXOLF]LQDQGSRSXODUL]HGLQWKHಬV E\&RXYHODLUHLQLWLDOO\IRUWKH7%EODGGHU DQGWKHPRUHUHFHQWDGPLQLVWUDWLRQRI LQWUDYHVLFDOERWXOLQXPWR[LQ$KDVIXUWKHULPSURYHGERWKKHDOWKDQGTXDOLW\RIOLIH LQ6&, Conclusions: 7KH FRPELQDWLRQ RI JRRG EODGGHU GUDLQDJH DQWLELRWLFV DQG JRRG SUHVVXUHFDUHKDVVHHQDGUDPDWLFUHGXFWLRQLQWKHGHDWKUDWHIURPORZHUXULQDU\ WUDFW DQG UHQDO FRPSOLFDWLRQV LQ 6&, SDWLHQWV IURP RYHU  LQ WKH HDUO\ WK FHQWXU\WRDURXQGDWWKHEHJLQQLQJRIWKHVW

‘DE URINIS TRACTATUS DUO’ BY H.J. REGA: A CONTRADICTORY TRACT THAT WAS THE BEGINNING OF THE END OF UROSCOPY

0DWWHODHU- AZ Groeninge Campus St. Maarten, Dept. of Urology, Kortrijk, Belgium Introduction & Objectives: +HQGULN -RVHI 5HJD   ZDV D IDPRXV SURIHVVRU RI FKHPLVWU\ DQG DQDWRP\ DW WKH XQLYHUVLW\ RI /RXYDLQ +H SXEOLVKHG LQ'H8ULQLV7UDFWDWXV'XRDVPDOOEXWYLROHQWWUDFWDJDLQVWWKHDEXVHVRI XURVFRS\E\GRFWRUVDQGTXDFNV Material & Methods: :HGHFLGHGWRWUDQVODWHWKHRULJLQDOODWLQWH[W Results: ,QWKHᚏUVWSDUW5HJDᚏQLVKHVWKHDUJXPHQWVRQXURVFRS\RI+LSSRFUDWHV DQGWKHFODVVLFDO5RPDQ%\]DQWLQHDQG$UDEVFLHQWLVWV+HSODFHVWKH0HGLFXV UDWLRQDOLVDJDLQVWWKH0HGLFXVXURVFRSXVVHXH[PDWXODRUಯSLVGRFWRUVರDQGJLYHV PXOWLSOHH[DPSOHVDQGDQHFGRWHV,QWKHVHFRQGSDUWKHH[SODLQVKLVRZQGRFWULQH RQWKHH[DPLQDWLRQRIXULQHLQDSKRULVPV Conclusions: 7KH ZRUN RI 5HJD SUHSDUHV WKH VFLHQWLᚏF SK\VLFDO DQG FKHPLFDO XULQDO\VLVWKDWZDVVWDUWHGE\5LFKDUG%ULJKW DQGKLVUROHRIDOEXPLQLULD LQQHSKURSDWK\

958

THE LIVING WITNESS ORAL HISTORY PROJECT

+RGJVRQ'-7KRPSVRQ30 1 Queen Alexandra Hospital, Dept. of Urology, Portsmouth, United Kingdom, 2 King’s College Hospital, Dept. of Urology, London, United Kingdom Introduction & Objectives: 8URORJ\ EHFDPH PRVW YLVLEO\ D VHSDUDWH VXUJLFDO VSHFLDOW\LQWKHಬVDQGಬV7KHSLRQHHUVIURPWKLVWLPHDUHHOGHUO\DQGWKHLU PHPRULHVPD\VRRQEHORVWIRUHYHU:HZDQWHGWRUHFRUGWKHLUUHFROOHFWLRQVRIWKH GHYHORSPHQWRIRXUGLVFLSOLQH Material & Methods: 2QH RI WKH DXWKRUV DWWHQGHG D FRXUVH RQ UHFRUGLQJ RUDO KLVWRULHV ,QLWLDOO\ WKH WKUHH VXUJHRQV ZKR ZH FRQVLGHU WR KDYH EHHQ WKH PRVW LQᚐXHQWLDO8URORJLVWVLQRXUFRXQWU\ZHUHDSSURDFKHG Results: &RQVHQWIRUXVLQJWKHPDWHULDOZDVREWDLQHG7KHLQWHUYLHZVZHUHWULSOH UHFRUGHGDQGWRRNEHWZHHQWZRDQGIRXUKRXUV&RPPRQWKHPHVFRYHUHGLQFOXGHG WKHLQWURGXFWLRQRIQHZWHFKQRORJLHVJRYHUQDQFHWUDLQLQJDQGWKHGHYHORSPHQWRI UHODWLRQVKLSVEHWZHHQIHOORZ(XURSHDQFRXQWULHV7KHLQWHUYLHZVZHUHWUDQVFULEHG DQGWKHUHFRUGLQJVPDGHDYDLODEOHIRUSXEOLFDFFHVVYLDWKHLQWHUQHW Conclusions: :HKDYHGHPRQVWUDWHGZLOOLQJQHVVDPRQJVWRXUVHQLRUFROOHDJXHV WRWDNHSDUWLQWKLVYHQWXUH:HKRSHWKDWZKDWZHKDYHDFKLHYHGZLOOOHDGWRIXUWKHU LQWHUHVWLQDQGLQYHVWLJDWLRQRIWKHKLVWRU\RI8URORJ\:HZRXOGOLNHWRHQFRXUDJH RWKHUVLQWHUHVWHGLQWKHHYROXWLRQRIRXUGLVFLSOLQHWRFDUU\RXWVLPLODUSURMHFWV

Poster Session 60 PREVENTION AND SCREENING OF PROSTATE CANCER Monday, 19 April, 15.45-17.15, Barcelona Room

959

EFFECT OF BASELINE PROSTATE CANCER RISK ON DUTASTERIDE EFFICACY IN THE REDUCE (REDUCTION BY DUTASTERIDE OF PROSTATE CANCER EVENTS) STUDY

0DUEHUJHU03HWWDZD\&7DPPHOD77LQGDOO'-7HORNHQ& :LOVRQ7+&DVWUR5 1 Medical University of Vienna, Dept. of Urology, Vienna, Austria, 2Anderson

Cancer Center, Urology Unit, Houston, United States of America, 3Tampere University Hospital, Dept. of Urology, Tampere, Finland, 4Mayo Clinic, Dept. of Urology & Biochemistry/molecular Biology, Rochester, United States of America, 5 Ufcspa - Federal University of Health Sciences, Dept. of Urology, Porto Alegre, Brazil, 6Glaxosmithkline, Statistics and Programming, Research Triangle Park, United States of America, 7Glaxosmithkline, Oncology Clinical Development and Medical Affairs, Research Triangle Park, United States of America Introduction & Objectives: 5('8&( LV D FRPSOHWHG \HDU VWXG\ RI SURVWDWH FDQFHU 3&D ULVNUHGXFWLRQ ZLWKGXWDVWHULGH 7KLVDQDO\VLV H[DPLQHV WKH HᚎHFWV RI EDVHOLQH SURVWDWH FDQFHU ULVN RQ SURVWDWH FDQFHU RFFXUUHQFH DQG GXWDVWHULGH ULVNUHGXFWLRQ Material & Methods: (OLJLEOH PHQ IRU WKH 5('8&( VWXG\ ZHUH UDQGRPL]HG WR GXWDVWHULGHRUSODFHERIRU\HDUVZHUHDJHGุDQGื\HDUVKDGDVHUXP 36$ ุ ದ QJPO GHSHQGLQJ RQ DJH DQG ื QJPO DQG D VLQJOH QHJDWLYH ELRSV\ RI ದ FRUHV 7UDQVUHFWDO XOWUDVRXQG GLUHFWHG ELRSVLHV  FRUHV  ZHUH WDNHQDWDQG\HDUV$IDPLO\KLVWRU\RI3&DLQFUHDVLQJDJHVPDOOHUSURVWDWH YROXPH39 ORZHUIUHH36$I36$ DQGDORZHUQXPEHURIFRUHVDWWKHELRSV\ SULRUWRHQUROOPHQWKDYHEHHQLGHQWLᚏHGDVWKHᚏYHVLJQLᚏFDQWS EDVHOLQH YDULDEOHVUHODWHGWRWKHLQFLGHQFHRI3&DDQGWR*OHDVRQದ3&DLQWKH5('8&( VWXG\(DFKRIWKHᚏYHEDVHOLQHULVNIDFWRUVZDVVFRUHGIURPOHDVWUHODWHG WR PRVWUHODWHG DQGDWRWDOULVNIDFWRUVFRUHWR ZDVFDOFXODWHGDJHื !ದ!ದ!\HDUVI36$ื!ದ!ದ!39ืFF!ದ  !ದ!FRUHVืದ! )DPLO\ KLVWRU\  ุ UHODWLYHV  7KH LQFLGHQFH RI 3&D LQ WKH WUHDWPHQW JURXSV LQ HDFK ULVN IDFWRU FDWHJRU\ ZDV FRPSDUHGXVLQJD0DQWHO+DHQV]HOWHVW Results: 7KH LQFLGHQFH RI DQ\ 3&D DQG *OHDVRQ ದ 3&D LQFUHDVHG LQ HDFK WUHDWPHQWJURXSDVWKHWRWDOULVNVFRUHLQFUHDVHG7DEOH 'XWDVWHULGHVLJQLᚏFDQWO\ S  UHGXFHG WKH LQFLGHQFH RI 3&D FRQWUROOLQJ IRU WKH QXPEHU RI ULVN IDFWRUV7UHDWPHQWGLᚎHUHQFHVLQ3&DLQFLGHQFHZHUHODUJHULQWKHWZRKLJKHVWULVN FDWHJRULHV7KHUHZDVQRVLJQLᚏFDQWLQFUHDVHLQ+*7ZLWKGXWDVWHULGHLQDQ\ULVN FDWHJRU\,QFLGHQFH RIDQ\3&DDQG+*7*OHDVRQದ DW
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Conclusions: 'XWDVWHULGHZDVHᚎHFWLYHDWUHGXFLQJWKHULVNRI3&DRYHUDOODFURVV DOO EDVHOLQH ULVN OHYHOV )XUWKHUPRUH GXWDVWHULGH GLG QRW VLJQLᚏFDQWO\ LQFUHDVH *OHDVRQದFDQFHUVLQDQ\ULVNFDWHJRU\

960

THE INFLUENCE OF A POSITIVE FAMILY HISTORY ON PROSTATE CANCER INCIDENCE AND DUTASTERIDE EFFICACY IN THE REDUCE STUDY

7DPPHOD7/-$QGULROH*/7HORNHQ&:LOVRQ7+)RZOHU,/ &DVWUR5 1 Tampere University Hospital, Dept. of Urology, Tampere, Finland, 2Washington University, School of Medicine, St. Louis, United States of America, 3Ufcspa Federal University of Health Sciences, Dept. of Urology, Porto Alegre, Brazil, 4 GlaxoSmithKline, Statistics and Programming, Research Triangle Park, United States of America, 5GlaxoSmithKline, Oncology MDC, Research Triangle Park, United States of America, 6GlaxoSmithKline, Oncology Clinical Development and Medical Affairs, Research Triangle Park, United States of America Introduction & Objectives: 5('8&( LV D FRPSOHWHG \HDU VWXG\ RI SURVWDWH FDQFHU3&D ULVNUHGXFWLRQZLWKGXWDVWHULGH7KLVDQDO\VLVH[DPLQHVWKHHᚎHFWVRI DIDPLO\KLVWRU\)+ RISURVWDWHFDQFHU3&D RQ3&DRXWFRPHVDQGGXWDVWHULGH HᚑFDF\ Material & Methods: (OLJLEOHPHQZHUHUDQGRPL]HGWRGXWDVWHULGHRUSODFHERIRU \HDUVZHUHDJHGุDQGื\HDUVKDGDVHUXP36$ದDQGDVLQJOH QHJDWLYH ELRSV\ RI ದ FRUHV ZLWKLQ  PRQWKV SULRU WR HQUROPHQW 7UDQVUHFWDO XOWUDVRXQGGLUHFWHGELRSVLHVFRUHV ZHUHWDNHQDWDQG\HDUV)+RI3&D EURWKHUIDWKHUJUDQGIDWKHUXQFOH ZDVFROOHFWHG Results: $PRQJWKHVXEMHFWVELRSVLHGZLWK)+DYDLODEOH KDG)+

RI3&D0RUHVXEMHFWVLQ86&DQDGD UHSRUWHG)+FRPSDUHGWR(8  DQGWKHUHVWRIWKHZRUOG $)+RI3&DDORQJZLWKLQFUHDVLQJDJHVPDOOHU SURVWDWHYROXPHORZHUIUHH36$DQGORZHUQXPEHURIFRUHVDWWKHHQWU\ELRSV\ ZHUHVLJQLᚏFDQW EDVHOLQH YDULDEOHV UHODWHGWRWKHLQFLGHQFH RI3&DDQG*OHDVRQ ದ3&DS 6XEMHFWVZLWK)+RI3&DKDGORZHUPHDQDJHYV \HDUV VPDOOHUEDVHOLQHSURVWDWHYROXPHYVFF EXWVLPLODUEDVHOLQH IUHH36$YV DQGQXPEHURIFRUHVVDPSOHGDWHQWU\ELRSV\YV FRUHV 7KHPDMRULW\RIVXEMHFWVZLWK)+RI3&DKDGRQO\RQHUHODWLYHDᚎHFWHG ZLWK IDWKHU EHLQJ WKH PRVW FRPPRQ 'XWDVWHULGH VLJQLᚏFDQWO\ UHGXFHG WKH ULVN RI 3&D LQ PHQ ZLWK S  RU ZLWKRXW )+ RI 3&D S  DQG WKH HᚎHFW ZDVKRPRJHQHRXVDFURVVUHJLRQV5HODWLYHULVNUHGXFWLRQIRUGXWDVWHULGHYHUVXV SODFHERIRUDQ\3&DLQVXEMHFWVZLWKQR)+ZDV>&,WR@ DQG>&,WR@LQWKRVHZLWK)+,QFLGHQFHRIDQ\3&DDQG *OHDVRQ ದ 3&D E\ )+VWDWXVLV JLYHQ LQ 7DEOH 7DEOH ,QFLGHQFH   RI RYHUDOO3&DDQG*OHDVRQದ3&DE\)DPLO\+LVWRU\ 3ODFHER

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*O *OHDVRQ Conclusions: 7KHLQFLGHQFHRI3&DRYHUDOODQG*OHDVRQದ3&DZDVKLJKHULQ PHQZLWKD)+RI3&D,WZDVDOVRKLJKHVWLQWKH86&DQDGDPRVWOLNHO\DVDUHVXOW RIDQLQFUHDVHGIUHTXHQF\RIVFUHHQLQJ3&DULVNUHGXFWLRQZLWKGXWDVWHULGHZDV JUHDWHULQPHQZLWKDSRVLWLYH)+DQGWKHUHZDVQRLQFUHDVHLQKLJKJUDGHWXPRUV LQWKHGXWDVWHULGHDUPLQPHQZLWKRUZLWKRXWDSRVLWLYH)+

961

EXTERNAL VALIDATION OF THE PROSTATE CANCER PREVENTION TRIAL RISK CALCULATOR IN A CANADIAN COHORT

7URWWLHU*)HUQDQGHV.%RVWURP3-)LQHOOL$7RL$/RFNZRRG*$ (YDQV$&KDGZLFN.)OHVKQHU1( 1 University of Toronto, Dept. of Surgical Oncology, Toronto, Canada, 2University of Toronto, Dept. of Biostatistics, Toronto, Canada, 3University of Toronto, Dept. of Radiology, Toronto, Canada, 4University of Toronto, Dept. of Pathology, Toronto, Canada Introduction & Objectives: 7KH SURVWDWH FDQFHU SUHYHQWLRQ WULDO 3&37  ULVN FDOFXODWRUZDVGHYHORSHGDVDWRROWRDVVLJQULVNRISURVWDWHFDQFHU3&D DQGKLJK JUDGH+* GLVHDVHDPRQJSDWLHQWVZKRDUHFRQVLGHUHGIRUSURVWDWHELRSV\3ULRU GDWDIURPRXU&DQDGLDQLQVWLWXWLRQKDYHVKRZQKLJKHUUDWHVRIFDQFHUGHWHFWLRQDW SURVWDWHELRSV\WKDQWKRVHSXEOLVKHGIURPRWKHUFHQWUHV:HVHWRXWWRGHWHUPLQHLI WKH3&37FDOFXODWRUSHUIRUPHGZHOOLQRXUFRKRUWDQGWRGHWHUPLQHLIWKHFDOFXODWRU KDVXWLOLW\DPRQJPHQ\HDUVRIDJH Material & Methods: 2XU LQVWLWXWLRQ SURVSHFWLYHO\ PDLQWDLQV D GDWDEDVH RI DOO SURVWDWHELRSVLHVRYHUWKHSDVW\HDUVQa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

Eur Urol Suppl 2010;9(2):301