The efficacy of tamsulosin in stone clearance after shock wave lithotripsy for renal calculi Eur Urol Suppl 2015;14/2;e99
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Teleb M. 1 , Dawod T.1 , Salem E. 1 , Ragab A. 1 , Shabana W.1 , Fawzi A. 1 , Kamel M. 1 , Wagdy A. 1 , Shalaby E. 2 , Kamel H.1 , Shahin A. 1 1 Zagazig
University, Faculty of Medicine, Dept. of Urology, Zagazig, Egypt, 2 Suez Canal University, Faculty of Medicine, Dept. of Urology,
Zagazig, Egypt INTRODUCTION & OBJECTIVES: To evaluate the efficacy of Tamsulosin 0.4 mg in fragments clearance after successful shock wave lithotripsy (SWL) for renal stones ≤ 2 cm. MATERIAL & METHODS: A prospective randomized study was conducted on 212 patients who underwent successful SWL (fragments < 4 mm) for single renal stone ≤ 2 cm in the period from March 2012 to April 2014. Included patients were divided into two groups; group I (n=106) was assigned to take an analgesic and anti-inflammatory only to facilitate clearance of SWL fragments, and group II (n=106) for which daily Tamsulosin 0.4 mg was added. Follow up of all patients 2 and 4 weeks after SWL was accomplished. The rate and timing of stone-free state achievement, the need for additional analgesia as well as occurrence of any complications were reported. RESULTS: The clearance rate for both stone categories of ≤ 1 cm and 1-2 cm pre-SWL maximal dimension was significantly better in group II (Tamsulosin) than that of group I (control) at 2 weeks of follow up after SWL (92.9% versus 67.7% and 83.3% versus 66.7% respectively). The overall clearance rate shows no statistically significant difference after 4 weeks of follow up (97.2% in group I versus 99.1% in group II). The need for additional analgesia and incidence of steinstrasse were significantly less in group II. CONCLUSIONS: Daily Tamsulosin 0.4 mg enhances clearance of stone fragments after SWL for renal stones and decrease the patients need for additional analgesics as well as the incidence of steinstrasse.