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A celebration of animal parasitism living together: The biology of animal parasitism
206
structure/function relaUonshtps and ramanon factor modtficaaons which regulate their acUwty, to an examination of a selected vanety of systems including heat shock, wral refection and developmental regulauon m whmch such regulatory mechamsms are relauvely well-founded, ff not completely yet understood The pnmory emphasis is on eukaryotlc translaaonal regulaUon although several papers on prokaryotlc nbosomal regulauon are included The mdtwdual chapters appear as mint rewews of specific topmcs in these areas and generally contam one or two key figures or tables of substannatmg data Understandably, they tend to promote the viewpoint of the laboratory making the presentation
A celebration of animal p a r a s i t i s m
TIBS 1 2 - May 1987
Ltm~tauons of space do not permit the presentanon of sufficient detad for the reader to compare and evaluate mdmvldual points made when different interpretations ernst Most chapters, however, are generally well-referenced and therefore serve as an excellent place to begin a more m-depth mvesngatmon of the current controversies in these areas Because of hmttat~ons on the number of participants attending the conference, several topics and/or points of view whtch would have been included m a larger book are notably missing The usefulness of thins pubhcaUon, however, msnot so much as a comprehensive overvmew of translaUonal regulaUon, but rather as a collechon of selected dlustra-
shovong the hfe cycles of vanous parastates and insect vectors and an equally Lmvmg T o g e t h e r The Biology o f handy index of parasite and vector A m m a l Parasmsm taxonomy at the end of the book Addiby Wdham Trager, Plenum Press 1986 tionally, some of the tables contain data $59 50 (xu + 467 pages) ISBN 0 306 collated from different sources by 423103 Trager, these would reqmre a qmte mtenswe hterature search to obtain For example, one table summanzes the Parasmtology has entered the molecular DNA content and genome stze of vanera and thts beautifully dlustrated and in- ous parasttes However, I dmd think that terestingly wmten work leads us from the seven-or-so tables that gave detmled classmcal paramology into this new and composmons of parasite culture media important era were unnecessary and could have been Ammal parames that hve on or m omttted from the book mthout in any other amraals are ~ndespread m nature way impamng Rs excellence and each parasite has evolved mrs own Many potatoes have complex deumque btology Trager effecuvely com- velopmental cycles that reqmre two or pares and contrasts, mnshort and Iogmcally more hosts, usually an invertebrate and arranged chapters, the cell biology, mm- a vertebrate host Each host species fremunology, biochemistry, ecology and quently has a hmlted number of dtffe~ent populatton btology of many ammal para- types of parasRe tnat can be assocmted sites The parasttes are placed m then with it, and each parasite also often has a proper biological context and due atten- restncted number of hosts that it can intton ms gwen to their Interactions wtth fect Host can modify parasmte and paraboth hosts and envnonment Parasites sRe can alter host, and therefore the that are covered range from the proto- host-parastte interactions are of fundazoan, Ameson mtchaehs, which hterally mental tmportance to our understanding rejects ttself into cells of rots blue crab of parastttc dmseases These mteractmns host, to the tapeworm, Splrometra man- are rightly constdered tn thins book to be sonotdes, whmch secretes a factor that a major feature of the bmology of parastimulates skeletal and muscular growth sttes, chapters that cover these areas, to produce excessively large mdwmduals particularly wRh respect to mtracellular of ~ts rodent hosts These are examples protozoa, malana, lemshrnamasms,trypanoof the veritable and impressive pot- son, uses and sclustosommsms, reveal the poum of animal parasites overvtewed mn types of inleract~ons that occur this book ,,¢,. Although ammal parasttes are fasEach chapter ms aptly dlustrated the cinating orgamsms, one should not book contains over 200 tables and fig- forget that they are responsible for a ures, many of which are stunmng and good deal of svffenng in human populamformatwe light a',d electron m~cro- tions, and Trager does not ignore thins graphs There is a useful introductory there as an mformauve chapter on parachapter that consists of 24 dmgrams state chemotherapy I was particularly
aons of how basic methods avmlable for the study of translaUonal regulauon have been successfully apphed Thins book ms therefore not targeted, only to specmhsts wor~ng m the area of translational regulauon Rather, ~t provides a generally well-written, useful and concise introduction to the overall area of translational regulatton for graduate students, as well as for research sclenttsts from other dlsclphnes who wish to examine gene regulation BRIAN S A F E R
Laboratory of Molecular Hematology, Sectton on ProtemSymhens, NaaonalHeart, Lungand Blood Insntute, NIH, Bethesda,AID20892, USA
glad to see the molecular structures of many of the drugs shown, because so many anttparaslttc drugs have names that suggest nothing about thew chemistry and mqumng blochemtsts must surely find this frustrating Living Together The Biology of Amreal Parasmsm vail undoubtedly be a useful and frequently consulted book for anyone who works wRh parasates, but tt wdl prove to be parUculady valuable for those of us that have recently entered parasitology from other areas of molecular b~ology and biochemistry To us, tt will be a readable source of informatmn on the range and biology of ammal parastates, and the hst of references m each chapter wdl provide an appropriate startmg point for further reformation The book should also be sUmulatmg reading for undergraduates who are considenng the posslblhty of entenng parasite research There msmuch to be dmscovered about ammal parasites and many fasonatmg as well as important problems have merely been touched at the molecular level A book such as this one, which bndges the gap between the macroscopmc and molecular aspects of parasRology and ms also readable and interesting, wdl be welcomed by many parasltologms Trager clearly appreciates the needs of parasRologmsts as well as the parasites themselves
F~ANKASHALL
Wolfson UnnlDepartmem oJ Medwul Protozool ogv, Ltmdo:: School of H)gwne a::d Trop:cal Medwme, KeppelSlreel London WCI, UK
structure/function relaUonshtps and ramanon factor modtficaaons which regulate their acUwty, to an examination of a selected vanety of systems including heat shock, wral refection and developmental regulauon m whmch such regulatory mechamsms are relauvely well-founded, ff not completely yet understood The pnmory emphasis is on eukaryotlc translaaonal regulaUon although several papers on prokaryotlc nbosomal regulauon are included The mdtwdual chapters appear as mint rewews of specific topmcs in these areas and generally contam one or two key figures or tables of substannatmg data Understandably, they tend to promote the viewpoint of the laboratory making the presentation
A celebration of animal p a r a s i t i s m
TIBS 1 2 - May 1987
Ltm~tauons of space do not permit the presentanon of sufficient detad for the reader to compare and evaluate mdmvldual points made when different interpretations ernst Most chapters, however, are generally well-referenced and therefore serve as an excellent place to begin a more m-depth mvesngatmon of the current controversies in these areas Because of hmttat~ons on the number of participants attending the conference, several topics and/or points of view whtch would have been included m a larger book are notably missing The usefulness of thins pubhcaUon, however, msnot so much as a comprehensive overvmew of translaUonal regulaUon, but rather as a collechon of selected dlustra-
shovong the hfe cycles of vanous parastates and insect vectors and an equally Lmvmg T o g e t h e r The Biology o f handy index of parasite and vector A m m a l Parasmsm taxonomy at the end of the book Addiby Wdham Trager, Plenum Press 1986 tionally, some of the tables contain data $59 50 (xu + 467 pages) ISBN 0 306 collated from different sources by 423103 Trager, these would reqmre a qmte mtenswe hterature search to obtain For example, one table summanzes the Parasmtology has entered the molecular DNA content and genome stze of vanera and thts beautifully dlustrated and in- ous parasttes However, I dmd think that terestingly wmten work leads us from the seven-or-so tables that gave detmled classmcal paramology into this new and composmons of parasite culture media important era were unnecessary and could have been Ammal parames that hve on or m omttted from the book mthout in any other amraals are ~ndespread m nature way impamng Rs excellence and each parasite has evolved mrs own Many potatoes have complex deumque btology Trager effecuvely com- velopmental cycles that reqmre two or pares and contrasts, mnshort and Iogmcally more hosts, usually an invertebrate and arranged chapters, the cell biology, mm- a vertebrate host Each host species fremunology, biochemistry, ecology and quently has a hmlted number of dtffe~ent populatton btology of many ammal para- types of parasRe tnat can be assocmted sites The parasttes are placed m then with it, and each parasite also often has a proper biological context and due atten- restncted number of hosts that it can intton ms gwen to their Interactions wtth fect Host can modify parasmte and paraboth hosts and envnonment Parasites sRe can alter host, and therefore the that are covered range from the proto- host-parastte interactions are of fundazoan, Ameson mtchaehs, which hterally mental tmportance to our understanding rejects ttself into cells of rots blue crab of parastttc dmseases These mteractmns host, to the tapeworm, Splrometra man- are rightly constdered tn thins book to be sonotdes, whmch secretes a factor that a major feature of the bmology of parastimulates skeletal and muscular growth sttes, chapters that cover these areas, to produce excessively large mdwmduals particularly wRh respect to mtracellular of ~ts rodent hosts These are examples protozoa, malana, lemshrnamasms,trypanoof the veritable and impressive pot- son, uses and sclustosommsms, reveal the poum of animal parasites overvtewed mn types of inleract~ons that occur this book ,,¢,. Although ammal parasttes are fasEach chapter ms aptly dlustrated the cinating orgamsms, one should not book contains over 200 tables and fig- forget that they are responsible for a ures, many of which are stunmng and good deal of svffenng in human populamformatwe light a',d electron m~cro- tions, and Trager does not ignore thins graphs There is a useful introductory there as an mformauve chapter on parachapter that consists of 24 dmgrams state chemotherapy I was particularly
aons of how basic methods avmlable for the study of translaUonal regulauon have been successfully apphed Thins book ms therefore not targeted, only to specmhsts wor~ng m the area of translational regulauon Rather, ~t provides a generally well-written, useful and concise introduction to the overall area of translational regulatton for graduate students, as well as for research sclenttsts from other dlsclphnes who wish to examine gene regulation BRIAN S A F E R
Laboratory of Molecular Hematology, Sectton on ProtemSymhens, NaaonalHeart, Lungand Blood Insntute, NIH, Bethesda,AID20892, USA
glad to see the molecular structures of many of the drugs shown, because so many anttparaslttc drugs have names that suggest nothing about thew chemistry and mqumng blochemtsts must surely find this frustrating Living Together The Biology of Amreal Parasmsm vail undoubtedly be a useful and frequently consulted book for anyone who works wRh parasates, but tt wdl prove to be parUculady valuable for those of us that have recently entered parasitology from other areas of molecular b~ology and biochemistry To us, tt will be a readable source of informatmn on the range and biology of ammal parastates, and the hst of references m each chapter wdl provide an appropriate startmg point for further reformation The book should also be sUmulatmg reading for undergraduates who are considenng the posslblhty of entenng parasite research There msmuch to be dmscovered about ammal parasites and many fasonatmg as well as important problems have merely been touched at the molecular level A book such as this one, which bndges the gap between the macroscopmc and molecular aspects of parasRology and ms also readable and interesting, wdl be welcomed by many parasltologms Trager clearly appreciates the needs of parasRologmsts as well as the parasites themselves
F~ANKASHALL
Wolfson UnnlDepartmem oJ Medwul Protozool ogv, Ltmdo:: School of H)gwne a::d Trop:cal Medwme, KeppelSlreel London WCI, UK