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A clinicopathologic study of melanocytic neoplasms
S70
Pathology (2014), 46(S2)
PATHOLOGY 2014 ABSTRACT SUPPLEMENT
accuracy of FNAB. US-FNAB and FNAB-Tg measurements of suspected lymph nodes were performed in 116 patients who underwent surgery because of DTC. Results of FNAB and corresponding FNAB-Tg values were compared to the histology of removed lymph nodes and to clinical follow-up. All patients with positive cytology (n ¼ 23) and two with elevated FNAB-Tg and negative cytology underwent surgery. Two patients with elevated FNAB-Tg and negative cytology were treated with J131 and one patient was not treated but only observed. In five patients with positive cytology, FNAB-Tg levels were not elevated. Three of these patients presented with cervical lymphadenopathy shortly after thyroidectomy and two had metastases from other malignancies.USFNAB is not sensitive enough to detect all metastatic lymph nodes. FNAB-Tg measurement increases diagnostic accuracy of the USFNAB of suspicious neck lymph nodes in the follow-up of patients with DTC, and is particularly useful in detecting small and cystic metastases and in cases of indeterminate cytology.
Cytopathology: Poster#092 UNSATISFACTORY CYTOLOGICAL SCREENING OF CERVICAL CANCER IN SRINAGARIND HOSPITAL Ratchaneegorn Thongbor, Nattcha Patarapadungkit, Emorn Pasatung, Punnatorn Sirivech, Nantaya Kunatippapong and Trai Wongsiri Department of Pathology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Results: Of the 50 cases, 12 (24%) were malignant melanoma and 38 (76%) were melanocytic nevi. Cutaneous melanocytic nevi was the most common, 30/38 (79%), followed by 8/38 (21%) conjunctival nevi. Head and neck was the most common site (25/38) and the mean age at presentation was 32.66þ16.19 years, the female to male ratio being 5.3:1. In melanoma, 4 (33%) were extracutaneous, of the cutaneous, 2 (17%) were acral lentiginous, and 6 (50%) were nodular. Mean age was 50þ16.99 years with an equal female to male ratio. The most common site was the extremities (6/8) in cutaneous lesions and choroid in extracutaneous (2/4) lesions. Concordance between clinical and histopathological diagnosis was found in 30/50 (60%) cases. Conclusion: Melanocytic nevi are quite common in females. Melanoma is rare, affecting men and women equally. In our context, melanoma likely represents a sporadic disorder. Difference from the western societies is the common occurrence of nodular melanoma here and the topographical distribution. Dermatopathology: Poster#094 CLINICOPATHOLOGIC ASPECTS OF CONGENITAL NEVI Claudia Florida Costea1, Camelia Tamas¸2 and Doinit¸a Ra˘dulescu3 1Department of Ophthalmology, UMF Gr T Popa Ias¸i, Romaˆnia, 2Departamentul de Chirurgie Plastica˘ s¸i Reparatorie, UMF Gr T Popa Ias¸i, Romaˆnia, and 3Department of Pathology, Universitatea Apollonia, Ias¸i, Romaˆnia
Dermatopathology: Poster#093
Background: This study was conducted to assess the risk of congenital giant nevus malignization. Material and methods: We studied 8 cases of congenital nevi in patients aged 10 to 32 years, (5 men, 3 women). Nevi were located on the eyelid (1 case), scalp (3 cases), and back (4 cases). The tumor diameter ranged from 0.5 to 12 cm. The surgically excised tumors were fixed in 10% formaldehyde, paraffin-embedded, and stained with hematoxylin-eosin, van Gieson, and Fontana. Results: The histological appearance was of junctional nevus, intradermal nevus and mixed nevus. Congenital melanocytic nevi showed some particular features: nevus cells frequently extended to the hypodermis, had a periadnexal location, and contained neuroid structures. The most common neuroid structures were composed of groups of cells resembling Wagner-Meissner corpuscles and Verocay body. In only one of our cases the giant congenital nevus underwent malignant change to malignant melanoma. Conclusions: Congenital nevi are benign circumscribed tumors formed of nevus cells that penetrate into the deep dermis with the involvement of skin appendages. Giant congenital nevus is a potential precursor of malignant melanoma.
A CLINICOPATHOLOGIC STUDY OF MELANOCYTIC NEOPLASMS
Dermatopathology: Poster#095
Cervical cancer is the second cause of death among cancer in Thai woman. The age range was around 45–55 years old and the disease incidence was 24.7 in 100,000 women. The Pap smear is the most common method to diagnose the abnormality of cervical cells. Unsatisfactory cytological screening means that the cytological screener could not diagnose the slide due to the amount or quality of cells in the slide. In Srinagarind Hospital from 2009 to 2011, there were 51,951 cases of Pap smear. From this amount, the unsatisfactory cytological finding was 168 cases or 0.003%. Most patients were aged over 60 years (73 cases, 43.5%) and the minority were aged less than 30 (3 cases, 1.8%). The most unsatisfactory Pap smears were found in patients from the radiotherapy unit (115 cases, 68.5%) and the minority were found in patients from the OB-Gyn unit (35 cases, 20.8%). The causes of unsatisfactory cytological screening could be from many factors such as method of sampling, age of patient and effects of radiation therapy.
Niharika Shah, R. C. Adhikari, Gita Sayami and Shovana Thapa Department of Pathology, Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal Background and objectives: This study reports baseline information about melanocytic neoplasms in TUTH. The objective was to study the histological spectrum of melanocytic nevi and melanoma, and to make a clinicohistopathological correlation. Methods: 50 consecutive cases of melanocytic neoplasms were studied from December 2010 to December 2011.
EXPRESSION OF KI-67 AND ESTROGEN RECEPTOR BETA IN PRIMARY MALIGNANT MELANOMA AS A POTENTIAL INDICATOR OF REGIONAL LYMPH NODE POSITIVITY Dalma Udovicic-Gagula1, Amina Ahmovic1, Nurija Bilalovic1 and Mirsad Doric2 1Department of Pathology, Clinical Center of the University of Sarajevo, Sarajevo, and 2Institut of Pathology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Copyright © Royal College of pathologists of Australasia. Unauthorized reproduction of this article is prohibited.
Pathology (2014), 46(S2)
PATHOLOGY 2014 ABSTRACT SUPPLEMENT
accuracy of FNAB. US-FNAB and FNAB-Tg measurements of suspected lymph nodes were performed in 116 patients who underwent surgery because of DTC. Results of FNAB and corresponding FNAB-Tg values were compared to the histology of removed lymph nodes and to clinical follow-up. All patients with positive cytology (n ¼ 23) and two with elevated FNAB-Tg and negative cytology underwent surgery. Two patients with elevated FNAB-Tg and negative cytology were treated with J131 and one patient was not treated but only observed. In five patients with positive cytology, FNAB-Tg levels were not elevated. Three of these patients presented with cervical lymphadenopathy shortly after thyroidectomy and two had metastases from other malignancies.USFNAB is not sensitive enough to detect all metastatic lymph nodes. FNAB-Tg measurement increases diagnostic accuracy of the USFNAB of suspicious neck lymph nodes in the follow-up of patients with DTC, and is particularly useful in detecting small and cystic metastases and in cases of indeterminate cytology.
Cytopathology: Poster#092 UNSATISFACTORY CYTOLOGICAL SCREENING OF CERVICAL CANCER IN SRINAGARIND HOSPITAL Ratchaneegorn Thongbor, Nattcha Patarapadungkit, Emorn Pasatung, Punnatorn Sirivech, Nantaya Kunatippapong and Trai Wongsiri Department of Pathology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Results: Of the 50 cases, 12 (24%) were malignant melanoma and 38 (76%) were melanocytic nevi. Cutaneous melanocytic nevi was the most common, 30/38 (79%), followed by 8/38 (21%) conjunctival nevi. Head and neck was the most common site (25/38) and the mean age at presentation was 32.66þ16.19 years, the female to male ratio being 5.3:1. In melanoma, 4 (33%) were extracutaneous, of the cutaneous, 2 (17%) were acral lentiginous, and 6 (50%) were nodular. Mean age was 50þ16.99 years with an equal female to male ratio. The most common site was the extremities (6/8) in cutaneous lesions and choroid in extracutaneous (2/4) lesions. Concordance between clinical and histopathological diagnosis was found in 30/50 (60%) cases. Conclusion: Melanocytic nevi are quite common in females. Melanoma is rare, affecting men and women equally. In our context, melanoma likely represents a sporadic disorder. Difference from the western societies is the common occurrence of nodular melanoma here and the topographical distribution. Dermatopathology: Poster#094 CLINICOPATHOLOGIC ASPECTS OF CONGENITAL NEVI Claudia Florida Costea1, Camelia Tamas¸2 and Doinit¸a Ra˘dulescu3 1Department of Ophthalmology, UMF Gr T Popa Ias¸i, Romaˆnia, 2Departamentul de Chirurgie Plastica˘ s¸i Reparatorie, UMF Gr T Popa Ias¸i, Romaˆnia, and 3Department of Pathology, Universitatea Apollonia, Ias¸i, Romaˆnia
Dermatopathology: Poster#093
Background: This study was conducted to assess the risk of congenital giant nevus malignization. Material and methods: We studied 8 cases of congenital nevi in patients aged 10 to 32 years, (5 men, 3 women). Nevi were located on the eyelid (1 case), scalp (3 cases), and back (4 cases). The tumor diameter ranged from 0.5 to 12 cm. The surgically excised tumors were fixed in 10% formaldehyde, paraffin-embedded, and stained with hematoxylin-eosin, van Gieson, and Fontana. Results: The histological appearance was of junctional nevus, intradermal nevus and mixed nevus. Congenital melanocytic nevi showed some particular features: nevus cells frequently extended to the hypodermis, had a periadnexal location, and contained neuroid structures. The most common neuroid structures were composed of groups of cells resembling Wagner-Meissner corpuscles and Verocay body. In only one of our cases the giant congenital nevus underwent malignant change to malignant melanoma. Conclusions: Congenital nevi are benign circumscribed tumors formed of nevus cells that penetrate into the deep dermis with the involvement of skin appendages. Giant congenital nevus is a potential precursor of malignant melanoma.
A CLINICOPATHOLOGIC STUDY OF MELANOCYTIC NEOPLASMS
Dermatopathology: Poster#095
Cervical cancer is the second cause of death among cancer in Thai woman. The age range was around 45–55 years old and the disease incidence was 24.7 in 100,000 women. The Pap smear is the most common method to diagnose the abnormality of cervical cells. Unsatisfactory cytological screening means that the cytological screener could not diagnose the slide due to the amount or quality of cells in the slide. In Srinagarind Hospital from 2009 to 2011, there were 51,951 cases of Pap smear. From this amount, the unsatisfactory cytological finding was 168 cases or 0.003%. Most patients were aged over 60 years (73 cases, 43.5%) and the minority were aged less than 30 (3 cases, 1.8%). The most unsatisfactory Pap smears were found in patients from the radiotherapy unit (115 cases, 68.5%) and the minority were found in patients from the OB-Gyn unit (35 cases, 20.8%). The causes of unsatisfactory cytological screening could be from many factors such as method of sampling, age of patient and effects of radiation therapy.
Niharika Shah, R. C. Adhikari, Gita Sayami and Shovana Thapa Department of Pathology, Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal Background and objectives: This study reports baseline information about melanocytic neoplasms in TUTH. The objective was to study the histological spectrum of melanocytic nevi and melanoma, and to make a clinicohistopathological correlation. Methods: 50 consecutive cases of melanocytic neoplasms were studied from December 2010 to December 2011.
EXPRESSION OF KI-67 AND ESTROGEN RECEPTOR BETA IN PRIMARY MALIGNANT MELANOMA AS A POTENTIAL INDICATOR OF REGIONAL LYMPH NODE POSITIVITY Dalma Udovicic-Gagula1, Amina Ahmovic1, Nurija Bilalovic1 and Mirsad Doric2 1Department of Pathology, Clinical Center of the University of Sarajevo, Sarajevo, and 2Institut of Pathology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Copyright © Royal College of pathologists of Australasia. Unauthorized reproduction of this article is prohibited.