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A comparison of isodose distributions and treatment techniques utilized in fast neutron therapy studies with those employed in megavoltage therapy
IN VITRO RBE DETERMINATIONS OF AN ENERGY MODULATED PROTON BEAM
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J. Tepper,l M. Goitein,' L. Verhey H. Suit,l A. Koehler,' E. Ha11,3 M. Raju,4, J. Robertson, 4 P. Todd,5 and R. Furlinitti5 1) Department of Radiation Medicine, Massachusetts General Hospital, 2) 3) 4) 5)
Boston, Massachusetts Harvard University Cyclotron, Cambridge, Massachusetts Department of Radiology, Columbia University, New York, New York Los Alamos Scientific Laboratory, Los Alamos, New Mexico University of Pennsylvania, University Park, Pennsylvania
In preparation of an expanded clinical trial of proton beam therapy utilizing the modulated energy 160 MV proton beam from the Harvard University Cyclotron an extensive series of experiments have been cgvpleted which were designed to estimate the RBE of the proton beam using Co (clinical therapy unit at MGH) as' the reference radiation. Scientists from four laboratories have performed experiments in this study. They have employed mammalian cells cultured --in vitro and cell survival as the end point. A wide spectrum of cell lines and culture techniques were utilized including V79, M3-1, T-l, H-4 and LICH. This report will detail the results from these various experiments. Analysis of these data yield RBE values in the range from 000 to 1.25. There is some indication of a decreased shoulder compared to Co I? in certain of the experiments, but this is not a consistent finding. The RBE values from these experiments in the center of the spread-out Bragg peak are centered at 1.10-l .15. The results are similar to those obtained from experiments using tissue response previously performed in our laboratory.
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A COMPARISON OF ISODOSE DISTRIBUTIONS AND TREATMENT TECHNIQUES UTILIZED IN FAST NEUTRON THERAPY STUDIES WITH THOSE EMPLOYED IN MEGAVOLTAGE THERAPY James A. Deye, Ph.D., Frances M. Fender, D.S.R.T., and Charles Roger:s, M.D. The Division of Radiation Therapy, The George Washington Unive,rsity Hospital, 901 23rd St., N.W., Washington, D.C.
Clinical ,trials in which the results of fast neutron therapy are to be compared with the results of the optimum conventional methods of treatment for some locally advanced tumors are currently in progress. Protocol arms include neutrons alone, photons alone and mixtures of the two in the same patient. The dosimetry distributions obtained from fast neutron beams have frequently been described as being inferior to the dose distributions Comparisons obtained from the use of modern teletherapy photon equipment. of isodose plots produced for tumors at various sites for photon and In addition the problems associated with neutron beams ,will be made. 135
obtaining equivalent dose distributions for tumor treated with mixed photon Methods in techniques and and neutron treatment will be discussed. positioning used for each modality will be compared.
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SATELLITE DIGITAL DISPLAY FOR THE CLINAC 18 R. G. Lane, M. D. Stevens, D. Lake, I. I. Rosen Biomedical Physics Division, University of New Mexico, Cancer Research and Treatment Center, Albuquerque, New Mexico
A satellite digital readout module which displays simultaneously all the positions of the gantry and collimator has been mounted on a control console of our Clinac 18. Continuous simultaneous display of gantry angle, collimator rotation, upper jaw position and lower jaw position has been found to be a useful safety feature. These critical treatment parameters can be observed from outside the treatment room during patient set-up procedures and during treatment for assurance of the correct set-up. This module has been found to be particularly helpful in electron beam treatments where the absorbed dose delivered per monitor unit is extremely dependent upon the collimator opening.
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HOSPITAL-BASED CANCER REGISTRY AND RADIATION THERAPY DATA Juan V. Fayos, M.D. Professor of Radiology, Radiation Therapy Department, University Hospital, Ann Arbor, Michigan 48109
The Cancer Registry at The University Hospital has been operational since 1936. Its objective has been to register all of the cancer cases that are seen at University Hospital and to maintain a continuous follow up of those cases. Input into the system has been made by the different services using appropriate coding sheets. The Radiation Therapy Division at the University of Michigan has also maintained a registry of patients, run independently of the Cancer Initially, a few items were recorded. Since 1974, radiation Registry. therapy patient data has been computerized. This permitted an increase in the number of items recorded as well as rapid retrieval and analysis of information not otherwise possible prior to the use of computer data systems. The present study details the advantages and problems encountered in the Hospital Cancer Registry and its inter-relation with an independent data system for Radiation Therapy. For this study, the author will analyze about 15,600 cases with cancer of the breast, lung, and uterus registered in the system. Emphasis upon retrieval of information, its validity, and integration with a radiation therapy data bank will be examined. costs of accumulating and retrieving the information will be presented. 136
(141)
1
J. Tepper,l M. Goitein,' L. Verhey H. Suit,l A. Koehler,' E. Ha11,3 M. Raju,4, J. Robertson, 4 P. Todd,5 and R. Furlinitti5 1) Department of Radiation Medicine, Massachusetts General Hospital, 2) 3) 4) 5)
Boston, Massachusetts Harvard University Cyclotron, Cambridge, Massachusetts Department of Radiology, Columbia University, New York, New York Los Alamos Scientific Laboratory, Los Alamos, New Mexico University of Pennsylvania, University Park, Pennsylvania
In preparation of an expanded clinical trial of proton beam therapy utilizing the modulated energy 160 MV proton beam from the Harvard University Cyclotron an extensive series of experiments have been cgvpleted which were designed to estimate the RBE of the proton beam using Co (clinical therapy unit at MGH) as' the reference radiation. Scientists from four laboratories have performed experiments in this study. They have employed mammalian cells cultured --in vitro and cell survival as the end point. A wide spectrum of cell lines and culture techniques were utilized including V79, M3-1, T-l, H-4 and LICH. This report will detail the results from these various experiments. Analysis of these data yield RBE values in the range from 000 to 1.25. There is some indication of a decreased shoulder compared to Co I? in certain of the experiments, but this is not a consistent finding. The RBE values from these experiments in the center of the spread-out Bragg peak are centered at 1.10-l .15. The results are similar to those obtained from experiments using tissue response previously performed in our laboratory.
(142)
A COMPARISON OF ISODOSE DISTRIBUTIONS AND TREATMENT TECHNIQUES UTILIZED IN FAST NEUTRON THERAPY STUDIES WITH THOSE EMPLOYED IN MEGAVOLTAGE THERAPY James A. Deye, Ph.D., Frances M. Fender, D.S.R.T., and Charles Roger:s, M.D. The Division of Radiation Therapy, The George Washington Unive,rsity Hospital, 901 23rd St., N.W., Washington, D.C.
Clinical ,trials in which the results of fast neutron therapy are to be compared with the results of the optimum conventional methods of treatment for some locally advanced tumors are currently in progress. Protocol arms include neutrons alone, photons alone and mixtures of the two in the same patient. The dosimetry distributions obtained from fast neutron beams have frequently been described as being inferior to the dose distributions Comparisons obtained from the use of modern teletherapy photon equipment. of isodose plots produced for tumors at various sites for photon and In addition the problems associated with neutron beams ,will be made. 135
obtaining equivalent dose distributions for tumor treated with mixed photon Methods in techniques and and neutron treatment will be discussed. positioning used for each modality will be compared.
(343)
SATELLITE DIGITAL DISPLAY FOR THE CLINAC 18 R. G. Lane, M. D. Stevens, D. Lake, I. I. Rosen Biomedical Physics Division, University of New Mexico, Cancer Research and Treatment Center, Albuquerque, New Mexico
A satellite digital readout module which displays simultaneously all the positions of the gantry and collimator has been mounted on a control console of our Clinac 18. Continuous simultaneous display of gantry angle, collimator rotation, upper jaw position and lower jaw position has been found to be a useful safety feature. These critical treatment parameters can be observed from outside the treatment room during patient set-up procedures and during treatment for assurance of the correct set-up. This module has been found to be particularly helpful in electron beam treatments where the absorbed dose delivered per monitor unit is extremely dependent upon the collimator opening.
(144)
HOSPITAL-BASED CANCER REGISTRY AND RADIATION THERAPY DATA Juan V. Fayos, M.D. Professor of Radiology, Radiation Therapy Department, University Hospital, Ann Arbor, Michigan 48109
The Cancer Registry at The University Hospital has been operational since 1936. Its objective has been to register all of the cancer cases that are seen at University Hospital and to maintain a continuous follow up of those cases. Input into the system has been made by the different services using appropriate coding sheets. The Radiation Therapy Division at the University of Michigan has also maintained a registry of patients, run independently of the Cancer Initially, a few items were recorded. Since 1974, radiation Registry. therapy patient data has been computerized. This permitted an increase in the number of items recorded as well as rapid retrieval and analysis of information not otherwise possible prior to the use of computer data systems. The present study details the advantages and problems encountered in the Hospital Cancer Registry and its inter-relation with an independent data system for Radiation Therapy. For this study, the author will analyze about 15,600 cases with cancer of the breast, lung, and uterus registered in the system. Emphasis upon retrieval of information, its validity, and integration with a radiation therapy data bank will be examined. costs of accumulating and retrieving the information will be presented. 136