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A comparison of the efficacy and tolerability of adapalene 0.1% gel versus tretinoin 0.025% in patients with acne vulgaris: A meta-analysis of five randomized trials
Posters -Acne
and related
unresponsive to or rapidly relapsing to 3 or more courses of convetional antibiotic therapy. They were 25-35 years old, 69 were female. They recieved 0.5 mg/kg/d for I week in every 4 weeks for a total period 6 months (total cumulative dose 21 mglkg). The patients were reviewed every 3 months and for I2 months following treatment. The result after 6 months course of treatment was satisfactory. The number of the inflammated lesions were reduced significantly in 67 of the patients (84%). Treatment was well tolerated by all patients. No abnormalities were found in the blood tests. All the patients are still under control for a period of other 12 months. I PlO
lsotretinoin (Roaccutane) in the treatment acne and seborrheic dermatitis
J. Bowszyc. University Department,
Pozna4
Medical Poland
School,
of
Dermatological
menty patients, I2 females and 8 males, from I6 to 29 years of age, with acne and severe seborrhea of the scalp and face, including 10 patients with acne and seborrheic dermatitis, were treated with isotretinoin (Roaccutane). Total isotretinoin dose was approximately 300 g and daily doses were from 20 to 60 mg (0.3-1.0 mg/kg).Except an emollient on the lips, no other systemic or topical treatment was used. Apart from dryness of lips and mucous membranes, nose bleeds were observed in 4 patients, thinning of the hair in 2 and elevation of disadvantageous fat metabolites (tri glicerydes) in 2 patients.Complete or almost complete remission of acne and clearing or marked improvement of seborrhea and seborrheic dermatitis were observed in all but one subjects. cream in acne vulgaris I PI 1 Linoladiol N. Berova, A. Nikolova, N. Kiriakova. Department Dermatology Bulgaria
and Venerologj;
Medical
University,
of Soja,
Acne Vulgaris is a disease that commonly occurs during adolescence with the beginning of the production of testosterone and activation of the sebaceous glands. Many investigators indicate that there is a significant decrease in the levels of linoleic acid in sebum of patients with acne and a contemporary increase of squalene and oleic acid. It has been proven that the comedones and the skin surface of acne patients contain much less linoleic acid and acylceramides than the skin of control subjects, which should be considered as a causative factor in the comedonogenesis. Our study was conducted on 20 volunteer patients with acne vulgaris gr. I-V. We treated them locally only with Linoladiol cream (Wolff - g.) containing a combination of estradiol and linoleic acid, applied once daily without any other treatment for one month. Our results proved a considerable improvement of the skin condition. We believe that this cream, particularly rich in linoleic acid and estrogens can be considered as a new useful pharmaceutical agent for the everyday acne therapy and cosmetic for acne prophylaxis.
disorders
IPI2
S189
A comparison of the efficacy and tolerability of adapalene 0.1% gel versus tretinoin 0.025% in patients with acne vulgaris: A meta-analysis of five randomized trials
W.J. Cunliffe’, M. Poncet*, C. Loeschez, M. Verschoore3. ‘The General Antipolis;
Infirmary, Leeds, UK; 2CIRD Galdertna, ‘Galderma Laboratories, Levallois-Pert-et,
Sophia France
The purpose of this meta-analysis was to determine if adapalene 0.1% gel provided superior efficacy and local tolerability to tretinoin 0.025% gel in the treatment of acne vulgaris. All comparative studies, both published and unpublished, from the United States and Europe, that fulfilled rigorous protocol criteria (multicenter, randomized, investigator-blind) were used. Five comparative studies met these criteria. In total, the meta-analysis evaluated 900 patients (450 treated with 0.1% adapalene, 450 treated with 0.025% tretinoin) with mild-tomoderate acne from the combined clinical trials. To avoid study bias, the meta-analysis used an intention-to-treat analysis. Statistical methodology for meta-analysis included analysis of covariance, analysis of variance and Cochran-Mantel-Haenszel (CMH) test. All statistical tests were two-sided, and the 0.05 probability level was used to establish statistical significance, and 95% confidence intervals were used to assess equivalence. Adapalene demonstrated equivalent efficacy to tretinoin in terms of reducing total lesion count. Adapalene demonstrated more rapid efficacy, as evidenced by a significant difference in the reduction of inflammatory and total lesions at week 1. Adapalene also demonstrated superior local tolerability at all evaluation periods. The findings from this meta-analysis suggest that adapalene 0.1% gel constitutes an attractive alternative to such classic retinoids as tretinoin for the treatment of acne vulgaris. ElPI 3
Comparison of adapalene solution, 0.1% and tretinoin gel, 0.025% in the topical treatment of acne vulgaris
C.N. Ellis’, L.E. Millikan*, E.B. Smith3, D.M. Chalker4, L.J. SwinyeS, I.H. Katz@, R.S. Berger’, O.H. Mills Jr’, M. Baker*, C. Loescheg, M. Verschoore’“. ‘Department of Dermatology,
University of Michigan, Ann Arbor; *Depar@nent Tulane University Medical Centec New Orleans; 3Departnlent of Dermatology, University of Texas Medical Branch, Galveston; 4Department of Dermatology, Medical College of Georgia, August; ‘Private Pmctice, Salt Luke City; 6Private Practice, Fridley; 7Hill Top Research, East Brunswick; ‘Galdenna Laboratories, Fort Worth, USA; ‘Cird Galderma, Sophia Antipolis; t”Galderma Laboratories, Levallois-Perret, France
of Dermatology,
A multicenter study was conducted to compare clinical safety and efficacy of adapalene solution, 0.1% and &etinoin gel, 0.02545, both topical treatments for acne in a once daily dosage regimen for 12 weeks. A total of 297 patients were enrolled by eight investigators in this randomised, investigator-masked study in a parallel group design. An open label period using adapalene followed this study to assess the long-term safety of adapalene solution. Adapalene and tretinoin proved to be clinically and statistically effective in treating acne by reducing inflammatory (47%
and related
unresponsive to or rapidly relapsing to 3 or more courses of convetional antibiotic therapy. They were 25-35 years old, 69 were female. They recieved 0.5 mg/kg/d for I week in every 4 weeks for a total period 6 months (total cumulative dose 21 mglkg). The patients were reviewed every 3 months and for I2 months following treatment. The result after 6 months course of treatment was satisfactory. The number of the inflammated lesions were reduced significantly in 67 of the patients (84%). Treatment was well tolerated by all patients. No abnormalities were found in the blood tests. All the patients are still under control for a period of other 12 months. I PlO
lsotretinoin (Roaccutane) in the treatment acne and seborrheic dermatitis
J. Bowszyc. University Department,
Pozna4
Medical Poland
School,
of
Dermatological
menty patients, I2 females and 8 males, from I6 to 29 years of age, with acne and severe seborrhea of the scalp and face, including 10 patients with acne and seborrheic dermatitis, were treated with isotretinoin (Roaccutane). Total isotretinoin dose was approximately 300 g and daily doses were from 20 to 60 mg (0.3-1.0 mg/kg).Except an emollient on the lips, no other systemic or topical treatment was used. Apart from dryness of lips and mucous membranes, nose bleeds were observed in 4 patients, thinning of the hair in 2 and elevation of disadvantageous fat metabolites (tri glicerydes) in 2 patients.Complete or almost complete remission of acne and clearing or marked improvement of seborrhea and seborrheic dermatitis were observed in all but one subjects. cream in acne vulgaris I PI 1 Linoladiol N. Berova, A. Nikolova, N. Kiriakova. Department Dermatology Bulgaria
and Venerologj;
Medical
University,
of Soja,
Acne Vulgaris is a disease that commonly occurs during adolescence with the beginning of the production of testosterone and activation of the sebaceous glands. Many investigators indicate that there is a significant decrease in the levels of linoleic acid in sebum of patients with acne and a contemporary increase of squalene and oleic acid. It has been proven that the comedones and the skin surface of acne patients contain much less linoleic acid and acylceramides than the skin of control subjects, which should be considered as a causative factor in the comedonogenesis. Our study was conducted on 20 volunteer patients with acne vulgaris gr. I-V. We treated them locally only with Linoladiol cream (Wolff - g.) containing a combination of estradiol and linoleic acid, applied once daily without any other treatment for one month. Our results proved a considerable improvement of the skin condition. We believe that this cream, particularly rich in linoleic acid and estrogens can be considered as a new useful pharmaceutical agent for the everyday acne therapy and cosmetic for acne prophylaxis.
disorders
IPI2
S189
A comparison of the efficacy and tolerability of adapalene 0.1% gel versus tretinoin 0.025% in patients with acne vulgaris: A meta-analysis of five randomized trials
W.J. Cunliffe’, M. Poncet*, C. Loeschez, M. Verschoore3. ‘The General Antipolis;
Infirmary, Leeds, UK; 2CIRD Galdertna, ‘Galderma Laboratories, Levallois-Pert-et,
Sophia France
The purpose of this meta-analysis was to determine if adapalene 0.1% gel provided superior efficacy and local tolerability to tretinoin 0.025% gel in the treatment of acne vulgaris. All comparative studies, both published and unpublished, from the United States and Europe, that fulfilled rigorous protocol criteria (multicenter, randomized, investigator-blind) were used. Five comparative studies met these criteria. In total, the meta-analysis evaluated 900 patients (450 treated with 0.1% adapalene, 450 treated with 0.025% tretinoin) with mild-tomoderate acne from the combined clinical trials. To avoid study bias, the meta-analysis used an intention-to-treat analysis. Statistical methodology for meta-analysis included analysis of covariance, analysis of variance and Cochran-Mantel-Haenszel (CMH) test. All statistical tests were two-sided, and the 0.05 probability level was used to establish statistical significance, and 95% confidence intervals were used to assess equivalence. Adapalene demonstrated equivalent efficacy to tretinoin in terms of reducing total lesion count. Adapalene demonstrated more rapid efficacy, as evidenced by a significant difference in the reduction of inflammatory and total lesions at week 1. Adapalene also demonstrated superior local tolerability at all evaluation periods. The findings from this meta-analysis suggest that adapalene 0.1% gel constitutes an attractive alternative to such classic retinoids as tretinoin for the treatment of acne vulgaris. ElPI 3
Comparison of adapalene solution, 0.1% and tretinoin gel, 0.025% in the topical treatment of acne vulgaris
C.N. Ellis’, L.E. Millikan*, E.B. Smith3, D.M. Chalker4, L.J. SwinyeS, I.H. Katz@, R.S. Berger’, O.H. Mills Jr’, M. Baker*, C. Loescheg, M. Verschoore’“. ‘Department of Dermatology,
University of Michigan, Ann Arbor; *Depar@nent Tulane University Medical Centec New Orleans; 3Departnlent of Dermatology, University of Texas Medical Branch, Galveston; 4Department of Dermatology, Medical College of Georgia, August; ‘Private Pmctice, Salt Luke City; 6Private Practice, Fridley; 7Hill Top Research, East Brunswick; ‘Galdenna Laboratories, Fort Worth, USA; ‘Cird Galderma, Sophia Antipolis; t”Galderma Laboratories, Levallois-Perret, France
of Dermatology,
A multicenter study was conducted to compare clinical safety and efficacy of adapalene solution, 0.1% and &etinoin gel, 0.02545, both topical treatments for acne in a once daily dosage regimen for 12 weeks. A total of 297 patients were enrolled by eight investigators in this randomised, investigator-masked study in a parallel group design. An open label period using adapalene followed this study to assess the long-term safety of adapalene solution. Adapalene and tretinoin proved to be clinically and statistically effective in treating acne by reducing inflammatory (47%