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A contribution to the Shwartzman phenomenon
The writers demonstrate that anaphylactic shock symptoms at three weeks are more pronounced when horse serum-insulin was used for sensitization but that at six weeks this difference is not demonstrable. Crystalline insulin was found to produce slightly more marked anaphylactic symptoms than the c>ommercial preparat,ions. Precipitin demonstration is reported as ineonalusive. Dale studies of the uterine strip were not performed.
A Contribution Ztschr.
to the Shwartzman
f. Immunitatsforsch.
Phenomenon.
II. exper. Therap.
Albus, G., and 92: 372, 1938.
Fischer,
I~.:
The writers report their experiments on the use of pollen antigen as the preparatory factor for the production of the Shwartzman phenomenon. Guinea pigs and rabbits were sensitized with a mixed pollen antigen by introducing 16 mg. of the dry pollen into the peritoneal cavity by operative procedure. The authors report practically 100 per rent sensitization with this technique The sensitized animals received preparatory doses of 0.3 C.C. mixed pollen antigen and a similar amount of H. coli filtrate in different regions of the abdomen. Following the intravenous injection of B. coli filtrate, 50 per cent of the animals developed a typical Shwartzman phenomenon at both sites, which were histologically similar. In control (nonsensitized) animals a Shwartznmn phenomenon was produced only at the The intravenous injection of a mixture of pollen site prepared with the filtrate. antigen and serum from pollen sensitized animals provoked no reaction in normal The provocaat,ive intravenous injection of animals prepared with 1;. coZi filtrate. 2 C.C. of pollen antigen into pollen sensitized animals, prepared with B. ooli filtrate, resulted in a moderate Shwartzman reaction in 25 per cent of the animals, together with varying degrees of shock symptoms.
Diphtheria
Immunization
and King-Brown,
With
W. W.:
Finely
Atomized
Form01 Toxoid.
Eonsfield,
CT.,
T,ancet 1: 491, 1938.
Successful attempts to stimulate the production of diphtheria antitoxin by the intranasal instillation of diphtheria toxoid have been reported by C. Jensen and by Bonsfield. Because of some objections raised to the use of this technique in small of this method. ehildren, the authors report their studies on a modification Five adults were subjected to two exposures, at fourteen days interval, of 50 C.V. titer deof form01 toxoid sprayed into a room. Blood was drawn for antitoxin terminations before the first exposure and again ten days after the second exposure. The writers report that all subjeot,s wit,11 a blood antitoxin titer of l/10 unit or more showed an increase up to 10 units after exposure to the formol toxoid spray. T’iolent headache, puffiness of the face and slight tightness of the chest occurred following exposure, especially in those eases developing high titers. To obviate the reactions obtained, the authors recommend the use of a more The suggestion is made that this met,hod of immunization be studied refined antigen. in other diseases.
Serologic ReStudies on Immunity in a Type of Human Allergy (Hay Fever): sponse of Non-sensitive Individuals to Pollen Antigens. Cooke, R. A., J,oveless, IN., and Stull,
A.:
J. Exper.
Med. 66: 689, 1937.
The authors, in a previous publication, demonstrated a phenomenon, produced in sensitive individuals by the injection of ragweed extract, due to a specific blocking In the present communication the writers report their intype of immune body. vestigations on the serologic response of nonsensitive individuals to pollen injections.
A Contribution Ztschr.
to the Shwartzman
f. Immunitatsforsch.
Phenomenon.
II. exper. Therap.
Albus, G., and 92: 372, 1938.
Fischer,
I~.:
The writers report their experiments on the use of pollen antigen as the preparatory factor for the production of the Shwartzman phenomenon. Guinea pigs and rabbits were sensitized with a mixed pollen antigen by introducing 16 mg. of the dry pollen into the peritoneal cavity by operative procedure. The authors report practically 100 per rent sensitization with this technique The sensitized animals received preparatory doses of 0.3 C.C. mixed pollen antigen and a similar amount of H. coli filtrate in different regions of the abdomen. Following the intravenous injection of B. coli filtrate, 50 per cent of the animals developed a typical Shwartzman phenomenon at both sites, which were histologically similar. In control (nonsensitized) animals a Shwartznmn phenomenon was produced only at the The intravenous injection of a mixture of pollen site prepared with the filtrate. antigen and serum from pollen sensitized animals provoked no reaction in normal The provocaat,ive intravenous injection of animals prepared with 1;. coZi filtrate. 2 C.C. of pollen antigen into pollen sensitized animals, prepared with B. ooli filtrate, resulted in a moderate Shwartzman reaction in 25 per cent of the animals, together with varying degrees of shock symptoms.
Diphtheria
Immunization
and King-Brown,
With
W. W.:
Finely
Atomized
Form01 Toxoid.
Eonsfield,
CT.,
T,ancet 1: 491, 1938.
Successful attempts to stimulate the production of diphtheria antitoxin by the intranasal instillation of diphtheria toxoid have been reported by C. Jensen and by Bonsfield. Because of some objections raised to the use of this technique in small of this method. ehildren, the authors report their studies on a modification Five adults were subjected to two exposures, at fourteen days interval, of 50 C.V. titer deof form01 toxoid sprayed into a room. Blood was drawn for antitoxin terminations before the first exposure and again ten days after the second exposure. The writers report that all subjeot,s wit,11 a blood antitoxin titer of l/10 unit or more showed an increase up to 10 units after exposure to the formol toxoid spray. T’iolent headache, puffiness of the face and slight tightness of the chest occurred following exposure, especially in those eases developing high titers. To obviate the reactions obtained, the authors recommend the use of a more The suggestion is made that this met,hod of immunization be studied refined antigen. in other diseases.
Serologic ReStudies on Immunity in a Type of Human Allergy (Hay Fever): sponse of Non-sensitive Individuals to Pollen Antigens. Cooke, R. A., J,oveless, IN., and Stull,
A.:
J. Exper.
Med. 66: 689, 1937.
The authors, in a previous publication, demonstrated a phenomenon, produced in sensitive individuals by the injection of ragweed extract, due to a specific blocking In the present communication the writers report their intype of immune body. vestigations on the serologic response of nonsensitive individuals to pollen injections.