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A high burden of vascular disease increases the risk of mild cognitive impairment: the mayo clinic study of aging.
Poster Presentations P2 diagnosed, and describe the patients with these disorders. Estimate the metrological parameters of the MOUS scale (Single domains Occupational Useful Score), was another objective. A cross sectional, national epidemiological study was set up. Investigators were asked to include 8 patients. They completed a questionnaire with MMSE, the diagnostic criteria apathy, diagnostic criteria for depression and comorbidity scale (CIRS). Patients completed a self-administered questionnaire, including inventory Apathy, Geriatric Depression Scale (GDS) and MOUS. Results: 734 patients were enrolled by 115 physicians. Patients were predominantly female (62%), with an age of 80 years (SD ¼ 6.6 years). Average MMSE was 23 (min 20-max 29). 41.6% (296) of patients completed the set of diagnostic criteria ’s apathy and 52.7% (381) had apathy clinical symptoms. 47,9% (340) of patients had a depression diagnosis. Patients with apathy had a lower average MMSE than patients without apathy (22.7 versus 23.4) and IADL scores lowest detection (2.5 vs. 3) and therefore (1.9 versus 2.6). They received more social assistance (APA)(22.4% versus 10.6%). 32.4% (225) of patients had both apathy and depression. 8.8 % (65) of patients had apathy alone, 14.6 % (107) depression alone and 40,6 %(298) neither apathy nor depression. These 4 groups of patients were different regarding age, social level, APA, age of diagnosis, MMSE, IADL and comorbidities. Concerning the MOUS scale, all domains were different between the 4 groups. Internal consistency was 0.697. Conclusions: The observed frequency of apathy and depression was 41.6%, respectively (n ¼ 296) and 47.9% (n ¼ 340). Typology of patients based on the presence or the combination of apathy and depression showed significant differences. Acknowledgment: ESTIME GROUP Support from: EISAI, PFIZER
P2-160
A HIGH BURDEN OF VASCULAR DISEASE INCREASES THE RISK OF MILD COGNITIVE IMPAIRMENT: THE MAYO CLINIC STUDY OF AGING.
Rosebud Roberts1, Yonas Geda1, David Knopman1, Ruth Cha1, Bradley Boeve1, V. Pankratz1, Walter Rocca1, Ronald Petersen1, 1Mayo Clinic, Rochester, Minnesota, United States. Background: The apolipoprotein e4 (APOE) allele is associated with increased risk of Alzheimer’s disease and amnestic MCI (a-MCI), a prodromal stage for Alzheimer’s disease. In contrast, non-amnestic MCI (na-MCI) is hypothesized to have a more heterogeneous etiology including vascular risk factors. However, the association of vascular disease burden with MCI subtypes has not been fully examined. Methods: We studied a prospective population-based cohort of Olmsted County, MN, residents aged 70-89 years on October 1, 2004. Participant evaluation at baseline and at 15-month intervals included a neurological evaluation and neuropsychological testing. Comorbid medical conditions at baseline were assessed from the medical record, and we computed a vascular risk score that takes into account several vascular risk factors (Framingham risk profile, D’Agostino et al., 2008). APOE genotyping was also performed. Results: Over a median follow-up of 4.3 years (interquartile range, 3.9-4.9 years), there were 296 incident cases of MCI among 1,450 subjects who were cognitively normal at baseline. APOE e4 allele was associated with incident MCI overall (hazard ratio [HR], 1.34; 95% confidence interval [CI], 1.01-1.77) and with a-MCI (HR, 1.55; 95% CI, 1.09-2.19), but not with na-MCI (HR, 1.29; 95% CI, 0.732.27) after adjustment for age, sex, and education. In contrast, a high vascular risk score (¼ upper quintile vs. otherwise) was associated both with naMCI (HR, 1.65; 95% CI, 1.04-2.63) and with a-MCI (HR, 1.36; 95% CI, 1.00-1.86). Conclusions: Our findings suggest different etiologic mechanisms for MCI subtypes. The etiology of a-MCI includes both neurodegenerative and vascular factors whereas the etiology of na-MCI includes primarily vascular factors.
P2-161
S363 PLASMA LONG-CHAIN OMEGA-3 FATTY ACIDS AND MEDIAL TEMPORAL LOBE ATROPHY: A LONGITUDINAL MRI STUDY
Cecilia Samieri1, Pauline Maillard2, Fabrice Crivello2, Evelyne Peuchant3, Catherine Helmer1, Michele Allard4, Jean-Francois Dartigues1, Stephen Cunnane5, Bernard Mazoyer2, Pascale Barberger-Gateau4, 1 ISPED, University Bordeaux 2, Bordeaux, France; 2CNRS, Centre d’imagerie-Neurosciences et Application aux pathologies, UMR6232; CEA, DSV/I2BM/CI-NAPS; Universite de Caen Basse Normandie, Caen, France; 3 Inserm, U876; CHU de Bordeaux, h^opital St andre, Bordeaux, France; 4 CHU de Bordeaux, service de medecine nucleaire, ERT-CNRS 5543, Bordeaux, France; 5Research center on aging, Health and social services Center; Sherbrooke University Geriatrics Institute; University of Sherbrooke, Sherbrooke, Quebec, Canada. Background: In spite of neuroprotective properties well documented in animal studies, the benefit of the long-chain omega-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in preventing Alzheimer Disease (AD) has not been clearly demonstrated. More research is needed to determine how EPA and DHA would be biologically related to pathological brain aging. We conducted a longitudinal Voxel-Based Morphometry (VBM) analysis based on the medial temporal lobe (MTL) to study whether, in this region particularly involved in AD, blood levels of EPA and DHA predicted lower grey matter volume loss after 4 yrs of follow-up. Methods: Among the Three-City study, a population-based cohort of older subjects, 281 participants with available plasma fatty acids at baseline underwent a cerebral MRI examination at baseline and at the 4 yr visit. VBM was performed using SPM8. A region of interest including the hippocampal complex and the amygdala was defined using the Automatic Anatomical Labelling SPM interface. Probability maps of annual grey matter (GM) change were calculated as the difference between the 4yr and baseline GM probability maps divided by the delay between the two MRI exams. Secondly, GM volumes at each time-point were extracted and annual GM volume change was computed in each MTL structure. Results: On a voxel-by-voxel basis, higher plasma EPA was associated with lower GM atrophy in the right amygdala and in the right hippocampal/parahippocampal area. Conclusions: Maintaining sufficient dietary supply of long-chain n-3 PUFA from fish, notably EPA, could help to compensate MTL tissue loss consequent to neurodegeneration in preclinical AD.
P2-162
BILINGUALISM AND INCIDENT DEMENTIA RISK: RESULTS FROM THE EINSTEIN AGING STUDY
Amy Sanders1, Charles Hall1, Mindy Katz1, Richard Lipton1, 1Albert Einstein College of Medicine, Bronx, New York, United States. Background: Several cross-sectional studies have suggested that bilingualism may be associated with lower risk of dementia. Speaking a second language is sometimes viewed as a form of cognitive stimulation. Some cognitively-stimulating activities have been shown to protect against the onset of dementia in older adults. Few longitudinal studies have investigated the effects of bilingualism on risk for incident dementia and MCI. This study tests the hypothesis that bilingualism is associated with lower risk of incident dementia and Mild Cognitive Impairment (MCI) in a prospective cohort study. Methods: Participants took part in the Einstein Aging Study (EAS), a longitudinal study of aging and cognition in the Bronx, NY. Participants (n ¼ 1777) self-reported first language learned, age of English acquisition, and the percentage of time they spoke a non-English language at home. All participants were fluent in English. In primary analysis, bilingualism was broadly defined as having a first language other than English. Dementia, amnestic MCI (aMCI), and non-amnestic MCI (naMCI) were diagnosed in consensus conferences according
P2-160
A HIGH BURDEN OF VASCULAR DISEASE INCREASES THE RISK OF MILD COGNITIVE IMPAIRMENT: THE MAYO CLINIC STUDY OF AGING.
Rosebud Roberts1, Yonas Geda1, David Knopman1, Ruth Cha1, Bradley Boeve1, V. Pankratz1, Walter Rocca1, Ronald Petersen1, 1Mayo Clinic, Rochester, Minnesota, United States. Background: The apolipoprotein e4 (APOE) allele is associated with increased risk of Alzheimer’s disease and amnestic MCI (a-MCI), a prodromal stage for Alzheimer’s disease. In contrast, non-amnestic MCI (na-MCI) is hypothesized to have a more heterogeneous etiology including vascular risk factors. However, the association of vascular disease burden with MCI subtypes has not been fully examined. Methods: We studied a prospective population-based cohort of Olmsted County, MN, residents aged 70-89 years on October 1, 2004. Participant evaluation at baseline and at 15-month intervals included a neurological evaluation and neuropsychological testing. Comorbid medical conditions at baseline were assessed from the medical record, and we computed a vascular risk score that takes into account several vascular risk factors (Framingham risk profile, D’Agostino et al., 2008). APOE genotyping was also performed. Results: Over a median follow-up of 4.3 years (interquartile range, 3.9-4.9 years), there were 296 incident cases of MCI among 1,450 subjects who were cognitively normal at baseline. APOE e4 allele was associated with incident MCI overall (hazard ratio [HR], 1.34; 95% confidence interval [CI], 1.01-1.77) and with a-MCI (HR, 1.55; 95% CI, 1.09-2.19), but not with na-MCI (HR, 1.29; 95% CI, 0.732.27) after adjustment for age, sex, and education. In contrast, a high vascular risk score (¼ upper quintile vs. otherwise) was associated both with naMCI (HR, 1.65; 95% CI, 1.04-2.63) and with a-MCI (HR, 1.36; 95% CI, 1.00-1.86). Conclusions: Our findings suggest different etiologic mechanisms for MCI subtypes. The etiology of a-MCI includes both neurodegenerative and vascular factors whereas the etiology of na-MCI includes primarily vascular factors.
P2-161
S363 PLASMA LONG-CHAIN OMEGA-3 FATTY ACIDS AND MEDIAL TEMPORAL LOBE ATROPHY: A LONGITUDINAL MRI STUDY
Cecilia Samieri1, Pauline Maillard2, Fabrice Crivello2, Evelyne Peuchant3, Catherine Helmer1, Michele Allard4, Jean-Francois Dartigues1, Stephen Cunnane5, Bernard Mazoyer2, Pascale Barberger-Gateau4, 1 ISPED, University Bordeaux 2, Bordeaux, France; 2CNRS, Centre d’imagerie-Neurosciences et Application aux pathologies, UMR6232; CEA, DSV/I2BM/CI-NAPS; Universite de Caen Basse Normandie, Caen, France; 3 Inserm, U876; CHU de Bordeaux, h^opital St andre, Bordeaux, France; 4 CHU de Bordeaux, service de medecine nucleaire, ERT-CNRS 5543, Bordeaux, France; 5Research center on aging, Health and social services Center; Sherbrooke University Geriatrics Institute; University of Sherbrooke, Sherbrooke, Quebec, Canada. Background: In spite of neuroprotective properties well documented in animal studies, the benefit of the long-chain omega-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in preventing Alzheimer Disease (AD) has not been clearly demonstrated. More research is needed to determine how EPA and DHA would be biologically related to pathological brain aging. We conducted a longitudinal Voxel-Based Morphometry (VBM) analysis based on the medial temporal lobe (MTL) to study whether, in this region particularly involved in AD, blood levels of EPA and DHA predicted lower grey matter volume loss after 4 yrs of follow-up. Methods: Among the Three-City study, a population-based cohort of older subjects, 281 participants with available plasma fatty acids at baseline underwent a cerebral MRI examination at baseline and at the 4 yr visit. VBM was performed using SPM8. A region of interest including the hippocampal complex and the amygdala was defined using the Automatic Anatomical Labelling SPM interface. Probability maps of annual grey matter (GM) change were calculated as the difference between the 4yr and baseline GM probability maps divided by the delay between the two MRI exams. Secondly, GM volumes at each time-point were extracted and annual GM volume change was computed in each MTL structure. Results: On a voxel-by-voxel basis, higher plasma EPA was associated with lower GM atrophy in the right amygdala and in the right hippocampal/parahippocampal area. Conclusions: Maintaining sufficient dietary supply of long-chain n-3 PUFA from fish, notably EPA, could help to compensate MTL tissue loss consequent to neurodegeneration in preclinical AD.
P2-162
BILINGUALISM AND INCIDENT DEMENTIA RISK: RESULTS FROM THE EINSTEIN AGING STUDY
Amy Sanders1, Charles Hall1, Mindy Katz1, Richard Lipton1, 1Albert Einstein College of Medicine, Bronx, New York, United States. Background: Several cross-sectional studies have suggested that bilingualism may be associated with lower risk of dementia. Speaking a second language is sometimes viewed as a form of cognitive stimulation. Some cognitively-stimulating activities have been shown to protect against the onset of dementia in older adults. Few longitudinal studies have investigated the effects of bilingualism on risk for incident dementia and MCI. This study tests the hypothesis that bilingualism is associated with lower risk of incident dementia and Mild Cognitive Impairment (MCI) in a prospective cohort study. Methods: Participants took part in the Einstein Aging Study (EAS), a longitudinal study of aging and cognition in the Bronx, NY. Participants (n ¼ 1777) self-reported first language learned, age of English acquisition, and the percentage of time they spoke a non-English language at home. All participants were fluent in English. In primary analysis, bilingualism was broadly defined as having a first language other than English. Dementia, amnestic MCI (aMCI), and non-amnestic MCI (naMCI) were diagnosed in consensus conferences according