- Email: [email protected]
A neuroendocrine-immune theory of ageing?
27 It is shown that in the course of learning the changing relevance of the feedback stimulus affects the SPN. Lateralization of the BP preceding right or left finger movements appeared to be useful for evaluation of the learning process and the development of an appropriate internal model. respectively.
A NEUROENDOCRINE-IMMUNE ING?
N. Fabris Immunol. Italy
Ctr. Res. Dpt. (INRCA),
GH concentrations were increased within the first 30 min postictslly only in the group of patients with generalized seizures. According to our preliminary data different types of hormonal responses probably are related to the evolution of certain types of epileptic attacks.
THEORY
OF AGE-
MULTICHANNEL OPTICAL TRANSMISSION SYSTEM: SAFETY FOR THE PATIENTS IN VEGETATIVE PARAMETER MEASUREMENTS
Via Birarelli
8. Ancona.
L. Fedina ‘, E. PCsztor ‘. J. Bencze ‘, Z. Zork6czy ’ and M. S6gor ’ Natl. Inst. of Neurosurgery ‘_ Res. Inst. of Telecommunication ‘, NOVA Techn. Devel. Ltd. ?. Budapest, Hungary
Among the systemic theories of ageing, the ‘immunological theory’ has received in the past some attention due to the apparently intrinsic derangement that occurs in the immune system with advancing age and to the impact that such a derangement has for various body functions. In fact some age-associated alterations in the neuroendocrine and in the immune system are mutually interdependent, as revealed by the fact that experimental manipulation on one of the two systems modifies and sometimes restores the function of the other one. Experimental and clinical evidence will be illustrated in support of the view that the age-associated failure of the thymus or of neuroendocrine centres is not an intrinsic phenomenon, but rather depends on modification occurring in the functionally-linked partner and that a ‘neuroendocrineimmune’ more than a pure ‘immunologic’ theory may offer a hetter approach to understand the ageing mechanisms.
SERUM PROLACTIN. GROWTH HORMONE, SOL AND BETA-ENDORPHINE RESPONSE FERENT TYPES OF EPILEPTIC ATTACKS
CORTITO DIF-
Annamaria Falus. Olga Eisler and Peter IIalasz National Institute for Nervous and Mental Diseases and Postgraduate Medical School Department of Neurology, Budapest, Hungary
Serum concentrations of prolactin (PRL). growth hormone (GH), cortisol (C’S) and beta-endorphine (BE) were measured following generalized seizures, complex partial seizures and functional seizures. Elevated levels of serum BE were ohserved in all types of seizures during the early post-seizure period at 15 and 30 min compared with the samples obtained following 24 h. Prolactin levels showed an increase in patients with generalized and complex partial seizures hut not in functional seizures. Serum CS levels obtained within the first 30 min following the generalized seizures were elevated compared with complex partial and functional seizures. Serum
Patient‘s safety is a most important problem in new complex measuring systems, even in non-invasive investigations. Our IS channel optical transmission system assures absolute safety. because there is no galvanic connection between the patient and the recording and analyzing instruments taking the power from the mains. The signal conditioning and the optical transmitter part is battery-driven. The speed of data transmisaion is 160 Kbit/s. the sampling rate i.\ I KHz with a resolution of IO hit, the distance of transmission is more than 1000 m. The parameters measured are ECG. respiration, central and peripheral pulse. phonocardiogram (taking 2 transmission ch.). photoplethysmographic pulse (2 ch.), galvanic skin resistance (2 ch.), temperature (2 ch.). EEG. EMG and a reaction time meter. Low pass filters of 24 dB/oktave with 20. 100. 500 and 800 Hz corner frequency are used to smooth the DA converted signals at the receiver output.
CHANGES OF GTP BINDING IN HORMONE OPIATE OR ADRENERGIC SUBSENSITIVITY M.I.K. Fekete, T. Szentendrei. Do. T, Kiem EGIS Pharmaceuticals. Inst. Exptl. Med., Hung. Budapest. Hungary
INDUCED
Acad.
Sci..
It has been published that a prolonged treatment with glucocorticoids or ACTH decreases the opiate agonist induced pituitary hormone release (Kanyicska et al. 1983). The glucocorticoid induced decreased sensitivity was also demonstrable by measuring alpha-3 adrenergic responses. Prolonged stress has minimized the effects of prolonged glucocorticoid trentment (Fekete et al. 1984). The decreased effectivity of icv given opioid peptide agonists as well as receptor binding studies suggest glucocorticoid induced changes in receptor sensitivity. The daily alterations of endocrine responses evoked by opioid peptides may occur independently of the presence of adrenals. Receptor binding studies have revealed altered GTP sensitivity of the binding of opiate and alphoadrenergic ligands. Decreases of adrenocortical reactivity similar to
A NEUROENDOCRINE-IMMUNE ING?
N. Fabris Immunol. Italy
Ctr. Res. Dpt. (INRCA),
GH concentrations were increased within the first 30 min postictslly only in the group of patients with generalized seizures. According to our preliminary data different types of hormonal responses probably are related to the evolution of certain types of epileptic attacks.
THEORY
OF AGE-
MULTICHANNEL OPTICAL TRANSMISSION SYSTEM: SAFETY FOR THE PATIENTS IN VEGETATIVE PARAMETER MEASUREMENTS
Via Birarelli
8. Ancona.
L. Fedina ‘, E. PCsztor ‘. J. Bencze ‘, Z. Zork6czy ’ and M. S6gor ’ Natl. Inst. of Neurosurgery ‘_ Res. Inst. of Telecommunication ‘, NOVA Techn. Devel. Ltd. ?. Budapest, Hungary
Among the systemic theories of ageing, the ‘immunological theory’ has received in the past some attention due to the apparently intrinsic derangement that occurs in the immune system with advancing age and to the impact that such a derangement has for various body functions. In fact some age-associated alterations in the neuroendocrine and in the immune system are mutually interdependent, as revealed by the fact that experimental manipulation on one of the two systems modifies and sometimes restores the function of the other one. Experimental and clinical evidence will be illustrated in support of the view that the age-associated failure of the thymus or of neuroendocrine centres is not an intrinsic phenomenon, but rather depends on modification occurring in the functionally-linked partner and that a ‘neuroendocrineimmune’ more than a pure ‘immunologic’ theory may offer a hetter approach to understand the ageing mechanisms.
SERUM PROLACTIN. GROWTH HORMONE, SOL AND BETA-ENDORPHINE RESPONSE FERENT TYPES OF EPILEPTIC ATTACKS
CORTITO DIF-
Annamaria Falus. Olga Eisler and Peter IIalasz National Institute for Nervous and Mental Diseases and Postgraduate Medical School Department of Neurology, Budapest, Hungary
Serum concentrations of prolactin (PRL). growth hormone (GH), cortisol (C’S) and beta-endorphine (BE) were measured following generalized seizures, complex partial seizures and functional seizures. Elevated levels of serum BE were ohserved in all types of seizures during the early post-seizure period at 15 and 30 min compared with the samples obtained following 24 h. Prolactin levels showed an increase in patients with generalized and complex partial seizures hut not in functional seizures. Serum CS levels obtained within the first 30 min following the generalized seizures were elevated compared with complex partial and functional seizures. Serum
Patient‘s safety is a most important problem in new complex measuring systems, even in non-invasive investigations. Our IS channel optical transmission system assures absolute safety. because there is no galvanic connection between the patient and the recording and analyzing instruments taking the power from the mains. The signal conditioning and the optical transmitter part is battery-driven. The speed of data transmisaion is 160 Kbit/s. the sampling rate i.\ I KHz with a resolution of IO hit, the distance of transmission is more than 1000 m. The parameters measured are ECG. respiration, central and peripheral pulse. phonocardiogram (taking 2 transmission ch.). photoplethysmographic pulse (2 ch.), galvanic skin resistance (2 ch.), temperature (2 ch.). EEG. EMG and a reaction time meter. Low pass filters of 24 dB/oktave with 20. 100. 500 and 800 Hz corner frequency are used to smooth the DA converted signals at the receiver output.
CHANGES OF GTP BINDING IN HORMONE OPIATE OR ADRENERGIC SUBSENSITIVITY M.I.K. Fekete, T. Szentendrei. Do. T, Kiem EGIS Pharmaceuticals. Inst. Exptl. Med., Hung. Budapest. Hungary
INDUCED
Acad.
Sci..
It has been published that a prolonged treatment with glucocorticoids or ACTH decreases the opiate agonist induced pituitary hormone release (Kanyicska et al. 1983). The glucocorticoid induced decreased sensitivity was also demonstrable by measuring alpha-3 adrenergic responses. Prolonged stress has minimized the effects of prolonged glucocorticoid trentment (Fekete et al. 1984). The decreased effectivity of icv given opioid peptide agonists as well as receptor binding studies suggest glucocorticoid induced changes in receptor sensitivity. The daily alterations of endocrine responses evoked by opioid peptides may occur independently of the presence of adrenals. Receptor binding studies have revealed altered GTP sensitivity of the binding of opiate and alphoadrenergic ligands. Decreases of adrenocortical reactivity similar to