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A nomogram for digoxin therapy
Brooker
G: A nomogram
for digoxin therapy.
Pharmacokinetics
Am J Med 57: 63-68,
Renal function
1974.
syndrome
gland involvement
Lacrimal
Scleroderma
Sclerosis gland involvement
Sicca features of Sjbgren’s syndrome were investigated in 25 consecutive patients with progressive systemic sclerosis by means of clinical examination, Schirmer’s tests, rose bengal staining tests, secretory parotid sialographies, scintillation scanning of salivary glands with 99-mTc pertechnetate, radionuclide salivary excretion studies and lip biopsies for study of minor salivary glands. The results indicate that Sjbgren’s syndrome does occur in the majority of patients with progressive systemic sclerosis. Because Sjbgren’s syndrome coexists almost exclusively with autoimmune disorders, our findings support the contention that progressive systemic sclerosis is related to autoimmunity.
Alar&n-Segovia D, Ib&ez G, Hernsndez-Ortiz J, Velhzquez-Forero F, GonztilezJimbnez Y: Sjbgren’s syndrome in progressive systemic sclerosis (scleroderma). Am J Med 57: 78-85, 1974.
Salivary
Sjtigren’s
A nomogram is described for developing loading and maintenance dosage regimens of digoxin for adult euthyroid patients with reasonably normal hepatic function, in normal electrolyte balance, who have no obvious abnormality of gastrointestinal absorption. The nomogram relates observed data of risk of adverse reactions, risk of arrhythmias, serum digoxin levels, calculated maximum total body digoxin concentrations, body weight, total oral loading dose, data of renal function and daily maintenance dose. Physicians may select an acceptable risk or peak serum level depending upon each patient’s clinical status, and then develop a loading and maintenance dosage regimen to consider giving, adjusted to the patient’s body weight and renal function, to achieve one’s selected therapeutic goals with reasonable accuracy for most patients most of the time.
Jelliffe RW.
Nomogram
Digoxin therapy
disease Cigarette
Alcoholism smoking
Chronic
bronchitis
Liver cirrhosis
Involvement
laparotomy Splenectomy
Staging
Radiation
therapy
Records of 99 consecutive previously untreated patients with Hodgkin’s disease subjected to laparotomy at our institution were reviewed to assess the frequency with which inadequate or inappropriate therapy might have been administered on the basis of clinical staging alone. Of the 86 patients judged to be candidates for aggressive radiation therapy prior to laparotomy (clinical stage less than IIIB) unsuspected disease was found in the porta hepatis lateral to the margin of the usual para-aortic radiation field in 4 and occult liver involvement in an additional 2. On the other hand, 2 patients with clinically suspected hepatic involvement were found to be free of parenchymal disease and therefore candidates for aggressive radiotherapy. In 3 patients with clinical stage IIA disease occult abdominal disease was discovered outside conventional extended field radiation ports. lt was not possible to reliably exclude the presence of occult disease outside standard abdominal radiation ports by previously published guidelines outlining indications for staging laparotomy.
O’Connell MJ, Wiernik PH. Sklansky BD, Greene WH, Abt AB, Kirschner RH, Ramsey HE, Murphy WL: Staging laparotomy in Hodgkin’s disease. Further evidence in support of its clinical utility. Am J Med 57: 86-9 1, 1974.
disease
Hodgkin’s Abdominal
To what extent does alcohol per se produce both respiratory symptoms and functional pulmonary impairments? To determine this an attempt was made to separate the pulmonary effects of alcohol from (1) the effects of previous pulmonary infections, (2) the effects of cigarette smoking, and (3) the effects of cirrhosis of the liver. The data suggest that either alcohol itself through some unknown mechanism may be a causative agent in producing lung diq ease or that alcohol makes a higher percentage of the population susceptible to the harmful effects of cigarette smoking.
Emirgil C, Sobol BJ, Heymann 8, Shibutani K, Reed A, Varble A, Waldie J: Pulmonary function in alcoholics. Am J Med 57: 69-77, 1974.
Dyspnea
Pulmonary
G: A nomogram
for digoxin therapy.
Pharmacokinetics
Am J Med 57: 63-68,
Renal function
1974.
syndrome
gland involvement
Lacrimal
Scleroderma
Sclerosis gland involvement
Sicca features of Sjbgren’s syndrome were investigated in 25 consecutive patients with progressive systemic sclerosis by means of clinical examination, Schirmer’s tests, rose bengal staining tests, secretory parotid sialographies, scintillation scanning of salivary glands with 99-mTc pertechnetate, radionuclide salivary excretion studies and lip biopsies for study of minor salivary glands. The results indicate that Sjbgren’s syndrome does occur in the majority of patients with progressive systemic sclerosis. Because Sjbgren’s syndrome coexists almost exclusively with autoimmune disorders, our findings support the contention that progressive systemic sclerosis is related to autoimmunity.
Alar&n-Segovia D, Ib&ez G, Hernsndez-Ortiz J, Velhzquez-Forero F, GonztilezJimbnez Y: Sjbgren’s syndrome in progressive systemic sclerosis (scleroderma). Am J Med 57: 78-85, 1974.
Salivary
Sjtigren’s
A nomogram is described for developing loading and maintenance dosage regimens of digoxin for adult euthyroid patients with reasonably normal hepatic function, in normal electrolyte balance, who have no obvious abnormality of gastrointestinal absorption. The nomogram relates observed data of risk of adverse reactions, risk of arrhythmias, serum digoxin levels, calculated maximum total body digoxin concentrations, body weight, total oral loading dose, data of renal function and daily maintenance dose. Physicians may select an acceptable risk or peak serum level depending upon each patient’s clinical status, and then develop a loading and maintenance dosage regimen to consider giving, adjusted to the patient’s body weight and renal function, to achieve one’s selected therapeutic goals with reasonable accuracy for most patients most of the time.
Jelliffe RW.
Nomogram
Digoxin therapy
disease Cigarette
Alcoholism smoking
Chronic
bronchitis
Liver cirrhosis
Involvement
laparotomy Splenectomy
Staging
Radiation
therapy
Records of 99 consecutive previously untreated patients with Hodgkin’s disease subjected to laparotomy at our institution were reviewed to assess the frequency with which inadequate or inappropriate therapy might have been administered on the basis of clinical staging alone. Of the 86 patients judged to be candidates for aggressive radiation therapy prior to laparotomy (clinical stage less than IIIB) unsuspected disease was found in the porta hepatis lateral to the margin of the usual para-aortic radiation field in 4 and occult liver involvement in an additional 2. On the other hand, 2 patients with clinically suspected hepatic involvement were found to be free of parenchymal disease and therefore candidates for aggressive radiotherapy. In 3 patients with clinical stage IIA disease occult abdominal disease was discovered outside conventional extended field radiation ports. lt was not possible to reliably exclude the presence of occult disease outside standard abdominal radiation ports by previously published guidelines outlining indications for staging laparotomy.
O’Connell MJ, Wiernik PH. Sklansky BD, Greene WH, Abt AB, Kirschner RH, Ramsey HE, Murphy WL: Staging laparotomy in Hodgkin’s disease. Further evidence in support of its clinical utility. Am J Med 57: 86-9 1, 1974.
disease
Hodgkin’s Abdominal
To what extent does alcohol per se produce both respiratory symptoms and functional pulmonary impairments? To determine this an attempt was made to separate the pulmonary effects of alcohol from (1) the effects of previous pulmonary infections, (2) the effects of cigarette smoking, and (3) the effects of cirrhosis of the liver. The data suggest that either alcohol itself through some unknown mechanism may be a causative agent in producing lung diq ease or that alcohol makes a higher percentage of the population susceptible to the harmful effects of cigarette smoking.
Emirgil C, Sobol BJ, Heymann 8, Shibutani K, Reed A, Varble A, Waldie J: Pulmonary function in alcoholics. Am J Med 57: 69-77, 1974.
Dyspnea
Pulmonary