- Email: [email protected]
A novel strategy to prepare 2D YBO3: Ce3 +-Yb3 +nanosheets with enhanced near-infrared (NIR) emission properties
Abstracts / Journal of Controlled Release 259 (2017) e5–e195
Fig. 1. Illustration of HCPT-loaded smart nanogel for enhanced intratumoral accumulation and triggered intracellular drug release.
Keywords: polycations, disulfide bond, polypeptide nanogel, tissue affinity, controlled drug delivery
e49
a research focus in drug delivery systems [2]. Recently, Twodimensional (2D) materials have attracted tremendous attention owing to their large surface area and special physical and chemical properties. In this work, 2D YBO3: Ce3 +-Yb3 + nanosheets were successfully prepared using liquid exfoliation method. The prepared nanosheets showed porous structure (Fig. 1a) which favored surface modification. The thickness of the nanosheets was ca. 3.932 nm (not shown here). In addition, 3D AFM image of the nanosheet surface (Fig. 1b) demonstrated the surface undulation of the nanosheets attributable to the porous structure. Moreover, the PL spectra in Fig. 1c indicated that the exfoliated nanosheets showed enhanced near-infrared (NIR) emission properties compared to the bulk (emission center: 971 nm, excited by 360 nm). Therefore, the nanosheets could enhance the energy transfer efficiency between Ce3 + and Yb3 + and show potential in drug delivery applications.
Acknowledgements This work was financially supported by National Natural Science Foundation of China (Projects 51303174, 51390484, 51233004, and 51473165). References [1] B.A. Carneiro, J.J. Meeks, T.M. Kuzel, M. Scaranti, S.A. Abdulkadir, F.J. Giles, Emerging therapeutic targets in bladder cancer, Cancer Treat. Rev. 41 (2015) 170-178. [2] N. Erdogar, A.B. Iskit, H. Eroglu, M.F. Sargon, N.A. Mungan, E. Bilensoy, Cationic core-shell nanoparticles for intravesical chemotherapy in tumor-induced rat model: Safety and efficacy, Int. J. Pharm. 471 (2014) 1-9. [3] F. Shi, J. Ding, C. Xiao, X. Zhuang, C. He, L. Chen, X. Chen, Intracellular microenvironment responsive PEGylated polypeptide nanogels with ionizable cores for efficient doxorubicin loading and triggered release, J. Mater. Chem. 22 (2012) 14168-14179.
Fig. 1. Characterization of 2D YBO3: Ce3 +-Yb3 + nanosheets. (a) TEM image. (b) 3D AFM image. (c) PL spectrum.
Keywords: 2D materials, YBO3: Ce3 +-Yb3 +, near-infrared (NIR), luminescence
doi:10.1016/j.jconrel.2017.03.120
Acknowledgements This work was financially supported by the National Natural Science Foundation of China (51372201, 21476183).
A novel strategy to prepare 2D YBO3: Ce3 +-Yb3 + nanosheets with enhanced near-infrared (NIR) emission properties
References
Hui Miaoa,b, Guowei Zhanga, Xiaoyun Hua,⁎, Enzhou Liuc, Jintao Baia, Xun Houb,d a School of Physics, Northwest University, Xi’an 710069, China b Institute of Photonics & Photon-Technology, Northwest University, Xi’an 710069, China c School of Chemical Engineering, Northwest University, Xi’an 710069, China d State Key Laboratory of Transient Optics and Technology, Xi’an Institute of Optics & Precision Mechanics, Chinese Academy of Sciences, Xi’an 710068, China ⁎Corresponding author. E-mail addresses: [email protected] (H. Miao), [email protected] (X. Hu) Over the past decades, much effort has been devoted to design of novel sustained/controlled drug delivery systems. However, as commonly used fluorescent components, organic dyes usually suffer from rapid photobleaching, poor stability and low quantum yield, while inorganic quantum dots (QDs) are plague from optical blinking and toxicity. For comparison, rare earth (RE) based inorganic materials exhibit good luminescent properties, chemical/photochemical inertness and low toxicity. Particularly, near-infrared (NIR) emission is highly desirable for bioimaging and controlled drug delivery because it enables high contrast in vivo imaging due to the lack of interference from tissue autofluorescence in the NIR window [1]. YBO3 based phosphors, due to their high optical efficiency, low toxicity and exceptional fluorescent damage threshold, have become
[1] J. Pennakalathil, A. Özgün, I. Durmaz, R.C. Atalay, D. Tuncel, pH-responsive nearinfrared emitting conjugated polymer nanoparticles for cellular imaging and controlled-drug delivery, Polym. Chem. 53 (2015) 114-122. [2] G.X. Yang, S.L. Gai, F.Y. Qu, P.P. Yang, SiO2@YBO3: Eu3 + hollow mesoporous spheres for drug delivery vehicle, ACS Appl. Mater. Interfaces 5 (2013) 5788-5796.
doi:10.1016/j.jconrel.2017.03.121
A light-responsive polymer for the co-delivery of anticancer drugs and therapeutic genes Hui Wanga,b, Wujun Miaoa, Dianwen Songa, Yiyun Chengb,⁎, Jianru Xiaoa,⁎ a Department of Orthopedic Oncology, Changzheng Hospital, the Second Military Medical University, Shanghai, 200003, China b Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China ⁎Corresponding authors. E-mail addresses: [email protected] (H. Wang), [email protected] (Y. Cheng), [email protected] (J. Xiao) Nanoscale stimuli-responsive systems for gene and drug delivery have recently received tremendous attention [1]. The systems that sensitive to a specific trigger may provide a specific release of the payloads at targeted regions or at controlled release profiles [2]. Herein,
Fig. 1. Illustration of HCPT-loaded smart nanogel for enhanced intratumoral accumulation and triggered intracellular drug release.
Keywords: polycations, disulfide bond, polypeptide nanogel, tissue affinity, controlled drug delivery
e49
a research focus in drug delivery systems [2]. Recently, Twodimensional (2D) materials have attracted tremendous attention owing to their large surface area and special physical and chemical properties. In this work, 2D YBO3: Ce3 +-Yb3 + nanosheets were successfully prepared using liquid exfoliation method. The prepared nanosheets showed porous structure (Fig. 1a) which favored surface modification. The thickness of the nanosheets was ca. 3.932 nm (not shown here). In addition, 3D AFM image of the nanosheet surface (Fig. 1b) demonstrated the surface undulation of the nanosheets attributable to the porous structure. Moreover, the PL spectra in Fig. 1c indicated that the exfoliated nanosheets showed enhanced near-infrared (NIR) emission properties compared to the bulk (emission center: 971 nm, excited by 360 nm). Therefore, the nanosheets could enhance the energy transfer efficiency between Ce3 + and Yb3 + and show potential in drug delivery applications.
Acknowledgements This work was financially supported by National Natural Science Foundation of China (Projects 51303174, 51390484, 51233004, and 51473165). References [1] B.A. Carneiro, J.J. Meeks, T.M. Kuzel, M. Scaranti, S.A. Abdulkadir, F.J. Giles, Emerging therapeutic targets in bladder cancer, Cancer Treat. Rev. 41 (2015) 170-178. [2] N. Erdogar, A.B. Iskit, H. Eroglu, M.F. Sargon, N.A. Mungan, E. Bilensoy, Cationic core-shell nanoparticles for intravesical chemotherapy in tumor-induced rat model: Safety and efficacy, Int. J. Pharm. 471 (2014) 1-9. [3] F. Shi, J. Ding, C. Xiao, X. Zhuang, C. He, L. Chen, X. Chen, Intracellular microenvironment responsive PEGylated polypeptide nanogels with ionizable cores for efficient doxorubicin loading and triggered release, J. Mater. Chem. 22 (2012) 14168-14179.
Fig. 1. Characterization of 2D YBO3: Ce3 +-Yb3 + nanosheets. (a) TEM image. (b) 3D AFM image. (c) PL spectrum.
Keywords: 2D materials, YBO3: Ce3 +-Yb3 +, near-infrared (NIR), luminescence
doi:10.1016/j.jconrel.2017.03.120
Acknowledgements This work was financially supported by the National Natural Science Foundation of China (51372201, 21476183).
A novel strategy to prepare 2D YBO3: Ce3 +-Yb3 + nanosheets with enhanced near-infrared (NIR) emission properties
References
Hui Miaoa,b, Guowei Zhanga, Xiaoyun Hua,⁎, Enzhou Liuc, Jintao Baia, Xun Houb,d a School of Physics, Northwest University, Xi’an 710069, China b Institute of Photonics & Photon-Technology, Northwest University, Xi’an 710069, China c School of Chemical Engineering, Northwest University, Xi’an 710069, China d State Key Laboratory of Transient Optics and Technology, Xi’an Institute of Optics & Precision Mechanics, Chinese Academy of Sciences, Xi’an 710068, China ⁎Corresponding author. E-mail addresses: [email protected] (H. Miao), [email protected] (X. Hu) Over the past decades, much effort has been devoted to design of novel sustained/controlled drug delivery systems. However, as commonly used fluorescent components, organic dyes usually suffer from rapid photobleaching, poor stability and low quantum yield, while inorganic quantum dots (QDs) are plague from optical blinking and toxicity. For comparison, rare earth (RE) based inorganic materials exhibit good luminescent properties, chemical/photochemical inertness and low toxicity. Particularly, near-infrared (NIR) emission is highly desirable for bioimaging and controlled drug delivery because it enables high contrast in vivo imaging due to the lack of interference from tissue autofluorescence in the NIR window [1]. YBO3 based phosphors, due to their high optical efficiency, low toxicity and exceptional fluorescent damage threshold, have become
[1] J. Pennakalathil, A. Özgün, I. Durmaz, R.C. Atalay, D. Tuncel, pH-responsive nearinfrared emitting conjugated polymer nanoparticles for cellular imaging and controlled-drug delivery, Polym. Chem. 53 (2015) 114-122. [2] G.X. Yang, S.L. Gai, F.Y. Qu, P.P. Yang, SiO2@YBO3: Eu3 + hollow mesoporous spheres for drug delivery vehicle, ACS Appl. Mater. Interfaces 5 (2013) 5788-5796.
doi:10.1016/j.jconrel.2017.03.121
A light-responsive polymer for the co-delivery of anticancer drugs and therapeutic genes Hui Wanga,b, Wujun Miaoa, Dianwen Songa, Yiyun Chengb,⁎, Jianru Xiaoa,⁎ a Department of Orthopedic Oncology, Changzheng Hospital, the Second Military Medical University, Shanghai, 200003, China b Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China ⁎Corresponding authors. E-mail addresses: [email protected] (H. Wang), [email protected] (Y. Cheng), [email protected] (J. Xiao) Nanoscale stimuli-responsive systems for gene and drug delivery have recently received tremendous attention [1]. The systems that sensitive to a specific trigger may provide a specific release of the payloads at targeted regions or at controlled release profiles [2]. Herein,