A PDZ-like domain mediates the dimerization of 11R-lipoxygenase

    A PDZ-like domain mediates the dimerization of 11R–lipoxygenase Priit Eek, Kaspar P˜oldemaa, Sergo Kasvandik, Ivar J¨arving, Nigulas Samel PII: DOI: Reference:

S1388-1981(17)30143-9 doi:10.1016/j.bbalip.2017.07.012 BBAMCB 58185

To appear in:

BBA - Molecular and Cell Biology of Lipids

Received date: Revised date: Accepted date:

9 March 2017 4 July 2017 26 July 2017

Please cite this article as: Priit Eek, Kaspar P˜ oldemaa, Sergo Kasvandik, Ivar J¨arving, Nigulas Samel, A PDZ-like domain mediates the dimerization of 11R–lipoxygenase, BBA - Molecular and Cell Biology of Lipids (2017), doi:10.1016/j.bbalip.2017.07.012

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

PT

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

*

*

 

NU

SC

RI

PT

ACCEPTED MANUSCRIPT



AC CE P

TE

D

MA



1

AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

AC CE P

TE

ε

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

λ π

θλ

θ

AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

∼

AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

≤

AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

SC

RI

PT

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

χ

 

ACCEPTED MANUSCRIPT

PT



MA

NU

SC

RI

χ

TE AC CE P



D







χ

 

PT

ACCEPTED MANUSCRIPT



NU

SC

RI



AC CE P

TE

D

MA









PT

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI





AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

 

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA





MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

AC CE P

TE

D





AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

π

AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

∼

AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

ACCEPTED MANUSCRIPT

ACCEPTED MANUSCRIPT

PT



MA

NU

SC

RI

∆

AC CE P

TE

D

χ

ACCEPTED MANUSCRIPT 

TE

D

MA

NU

SC

RI

PT



AC CE P



MA



NU

SC

RI

PT

ACCEPTED MANUSCRIPT

AC CE P

TE

D





 



ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

Figure 1

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

Figure 2

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

Figure 3

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

Figure 4

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

Figure 5

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

Figure 6

ACCEPTED MANUSCRIPT

AC CE P

TE

D

MA

NU

SC

RI

PT

Graphical Abstract