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A placebo controlled randomized trial on the effects of supplemental nutrition alone or combined with nandrolone decanoate (decadurabolin) on body composition and physical performance in depleted COPD patients
0.74 A placebo controlled randomized trial on the effects of supplemental nutrition alone or combined with nandrolone decanoate (decadurabolin) on body composition and physical performance in depleted COPD patients.
Statistics: An interim analysis was scheduled after 75 patients had completed the study. Analysis of covariance was performed with the pretreatment value as covariable, and considering treatment and exercise intensity as factors in the statistical model. Results: Dietary intake was 160% of measured resting metabolic rate in the treated groups and 140% in the placebo group (p i 0.05). The 97% confidence interval (Cl) of the paired treatment contrasts indicated a significant improvement in body weight (N-P):1.8 kg(Cl:O.3-3.4)(A-P):2.1 kg(0.5-3.7) and FFM (N-P):1.7 kg (0.3-3.1), (A-P):2.8 kg (1.54.2) and creatinine height index (A-P) : 18.3%(3.633.1 ). A significant exercisextreatment interaction was found for weight (p < 0.005), FFM (p < 0.01) and percent fat mass (p < 0.05). Within-group comparison revealed significant improvements of inspiratory vital capacity amounting to 12% (p < 0.05) in both treated groups and of respiratory muscle strength (N) 7% p = 0.02, (A) 26% p < 0.005). Conclusion: A daily nutntional supplement in addition to a normal dietary intake, as part of a general physical training program, gradually increases FFM in depleted COPDpatients. Supportive treatment with nandrolone decanoate may enhance the increase in FFM while body weight gain is similar. Schols AMWJ, et al. Am Rev Respir Dis 1993; 147: in press
A. M. W. J. Schols, P. B. Soeters’, R. J. Pluymerti, R. Master?, E. F. M. Wouters Depts of Pulmonology and Surgery’, University of Limburg, Maastricht, Asthmacentre Hornerheide3, and Organon lnternational, Oss, The Netherlands Introduction: We investigated in a placebo (P) controlled randomized trial the effects of supplemental nutrition (N) alone or combined with an anabolic steroid (A) on body composition and physical performance in 125 depleted” patients with chronic obstructive pulmonary disease (COPD). Methods: The trial was conducted as an integrated part of an 8 weeks in-patient pulmonary rehabilitation program. The anabolic steroid nandrolone decanoate or placebo was administered by i.m. injection (925 mg/$50 mg) in a double blind fashion on days 1, 15, 29 and 43. The nutritional supplement (420 kcal) was administered daily. Body composition was assessed by bioelectrical impedance analysis, validated to assess changes in fat-free mass (FFM) using deuterium dilution as reference method. Respiratory muscle strength and 12 minute walking distance were evaluated as measures of physical performance.
Topic 14-MICRONUTRIENTS AND VITAMINS Topic 15-HORMONES AND MEDIATORS Homocysteinemia an indicator of vitamin 0.75
in chronic deficiencies?
alcoholics:
value for total serum homocysteine ( > 20 nmol/ml) there was a significant negative correlation between homocystein, and PLP (r= -0.66; P= 0.01) as well as with vitamin B6 levels (r = -0.50; P = 0.05). Serum folate was negatively correlated to serum homocysteine but did not reach statistical significance (r = -0.47; P = 0.07). This study suggests that in the presence of normal circulating levels of these vitamins, an increased total serum homocysteine may be an early indicator of low intracellular vitamin B6 and its active metabolite, PLP, and possibly, folate.
M. Cravo, L. Gloria, M. Nadeau, A. Gouveia-Oliveira, M. Resende, J. Selhub, M. E. Camilo, J. N. Cardoso, C. Nobre Leitao, F. Costa Mira S. Gastrenterologia do IPOFG e S. Psiquiatria e de Medicina II do HSM, Lisboa, Portugal, Bioavailability Laboratory, #NRC at Tufts University, Boston, USA Chronic alcoholism is frequently associated with vitamin deficiencies including folic acid and vitamin B6. These may impair several metabolic processes such as the remethylation of homocysteine into methionine (folate and vitamin B12dependent) and/or the conversion of homocysteine into cystathionine which is catalysed by a pyridoxal-5’-phosphate (PLP)-containing enzyme. Therefore, the cellular depletion of either of these vitamins, can result in homocisteinemia. The aim of the present study was to evaluate the value of total serum homocysteine in relation to folate, B6 and B12 status in a population of 27 chronic alcoholics with an intake > 1.5 g/Kg/day for more than 5 years, as compared to a group of 10 normal controls. Age and sex distribution was similar in both groups. Serum folate was measured using the Lactobacillus Casei microbiologic assay, vitamin B12 was evaluated using a radioassay method and total serum homocysteine, PLP and vitamin B6 were measured by HPLC. Vitamin levels were within the reference range in all subjects and there was no significant differences between alcoholics and controls. However, total serum homocvsteine was significantly higher in chronic alcoholics as compared to controls: 21.13+9.24 vs ll.Oi4.3 nmol/ml; P= 0.005. Also, considering the 11 alcoholic subjects who had an abnormal
0.76 Antioxidant status of patients on hemodialysis before and after parenteral supplementation with sodium selenite J. S. Koenig’, E. Bulant’, W. Drum?, M. Fische?, P. Balcke’, I. Elmadfa’ Institute of Nutrition, University Vienna’. Department of Nephrology, University Vienna=, Austria Introduction: Hemodialysis leads to an affected stability of erythrocyte membranes. This can be caused by a decreased potency of the antioxidative nutrients vit. E, vit. C, selenium, and others. The aim of the present study was to evaluate the possible effects of a controlled i.v. selenium supplementation. Methods: Twelve patients (6 0, 6 f) at an age of 32-78 years and on hemodialysis for a minimum of 5 months were supplemented intravenously with 400 pug selenium (as sodium selenite) three times per week. Blood samples were taken before start (time 0), at intervals of 2 weeks during (time 14) and 4 weeks after the period of 8 week of 27
Statistics: An interim analysis was scheduled after 75 patients had completed the study. Analysis of covariance was performed with the pretreatment value as covariable, and considering treatment and exercise intensity as factors in the statistical model. Results: Dietary intake was 160% of measured resting metabolic rate in the treated groups and 140% in the placebo group (p i 0.05). The 97% confidence interval (Cl) of the paired treatment contrasts indicated a significant improvement in body weight (N-P):1.8 kg(Cl:O.3-3.4)(A-P):2.1 kg(0.5-3.7) and FFM (N-P):1.7 kg (0.3-3.1), (A-P):2.8 kg (1.54.2) and creatinine height index (A-P) : 18.3%(3.633.1 ). A significant exercisextreatment interaction was found for weight (p < 0.005), FFM (p < 0.01) and percent fat mass (p < 0.05). Within-group comparison revealed significant improvements of inspiratory vital capacity amounting to 12% (p < 0.05) in both treated groups and of respiratory muscle strength (N) 7% p = 0.02, (A) 26% p < 0.005). Conclusion: A daily nutntional supplement in addition to a normal dietary intake, as part of a general physical training program, gradually increases FFM in depleted COPDpatients. Supportive treatment with nandrolone decanoate may enhance the increase in FFM while body weight gain is similar. Schols AMWJ, et al. Am Rev Respir Dis 1993; 147: in press
A. M. W. J. Schols, P. B. Soeters’, R. J. Pluymerti, R. Master?, E. F. M. Wouters Depts of Pulmonology and Surgery’, University of Limburg, Maastricht, Asthmacentre Hornerheide3, and Organon lnternational, Oss, The Netherlands Introduction: We investigated in a placebo (P) controlled randomized trial the effects of supplemental nutrition (N) alone or combined with an anabolic steroid (A) on body composition and physical performance in 125 depleted” patients with chronic obstructive pulmonary disease (COPD). Methods: The trial was conducted as an integrated part of an 8 weeks in-patient pulmonary rehabilitation program. The anabolic steroid nandrolone decanoate or placebo was administered by i.m. injection (925 mg/$50 mg) in a double blind fashion on days 1, 15, 29 and 43. The nutritional supplement (420 kcal) was administered daily. Body composition was assessed by bioelectrical impedance analysis, validated to assess changes in fat-free mass (FFM) using deuterium dilution as reference method. Respiratory muscle strength and 12 minute walking distance were evaluated as measures of physical performance.
Topic 14-MICRONUTRIENTS AND VITAMINS Topic 15-HORMONES AND MEDIATORS Homocysteinemia an indicator of vitamin 0.75
in chronic deficiencies?
alcoholics:
value for total serum homocysteine ( > 20 nmol/ml) there was a significant negative correlation between homocystein, and PLP (r= -0.66; P= 0.01) as well as with vitamin B6 levels (r = -0.50; P = 0.05). Serum folate was negatively correlated to serum homocysteine but did not reach statistical significance (r = -0.47; P = 0.07). This study suggests that in the presence of normal circulating levels of these vitamins, an increased total serum homocysteine may be an early indicator of low intracellular vitamin B6 and its active metabolite, PLP, and possibly, folate.
M. Cravo, L. Gloria, M. Nadeau, A. Gouveia-Oliveira, M. Resende, J. Selhub, M. E. Camilo, J. N. Cardoso, C. Nobre Leitao, F. Costa Mira S. Gastrenterologia do IPOFG e S. Psiquiatria e de Medicina II do HSM, Lisboa, Portugal, Bioavailability Laboratory, #NRC at Tufts University, Boston, USA Chronic alcoholism is frequently associated with vitamin deficiencies including folic acid and vitamin B6. These may impair several metabolic processes such as the remethylation of homocysteine into methionine (folate and vitamin B12dependent) and/or the conversion of homocysteine into cystathionine which is catalysed by a pyridoxal-5’-phosphate (PLP)-containing enzyme. Therefore, the cellular depletion of either of these vitamins, can result in homocisteinemia. The aim of the present study was to evaluate the value of total serum homocysteine in relation to folate, B6 and B12 status in a population of 27 chronic alcoholics with an intake > 1.5 g/Kg/day for more than 5 years, as compared to a group of 10 normal controls. Age and sex distribution was similar in both groups. Serum folate was measured using the Lactobacillus Casei microbiologic assay, vitamin B12 was evaluated using a radioassay method and total serum homocysteine, PLP and vitamin B6 were measured by HPLC. Vitamin levels were within the reference range in all subjects and there was no significant differences between alcoholics and controls. However, total serum homocvsteine was significantly higher in chronic alcoholics as compared to controls: 21.13+9.24 vs ll.Oi4.3 nmol/ml; P= 0.005. Also, considering the 11 alcoholic subjects who had an abnormal
0.76 Antioxidant status of patients on hemodialysis before and after parenteral supplementation with sodium selenite J. S. Koenig’, E. Bulant’, W. Drum?, M. Fische?, P. Balcke’, I. Elmadfa’ Institute of Nutrition, University Vienna’. Department of Nephrology, University Vienna=, Austria Introduction: Hemodialysis leads to an affected stability of erythrocyte membranes. This can be caused by a decreased potency of the antioxidative nutrients vit. E, vit. C, selenium, and others. The aim of the present study was to evaluate the possible effects of a controlled i.v. selenium supplementation. Methods: Twelve patients (6 0, 6 f) at an age of 32-78 years and on hemodialysis for a minimum of 5 months were supplemented intravenously with 400 pug selenium (as sodium selenite) three times per week. Blood samples were taken before start (time 0), at intervals of 2 weeks during (time 14) and 4 weeks after the period of 8 week of 27