- Email: [email protected]
A testing system for drug-induced peripheral neuropathy in mice
A strong correlation was demonstrated between calculated time-dose factors (TDF) and survival at 1 year. There is a definite upward trend (increased survival with higher TDF). Comparative isodoses, actuarial survival curves and TDF graphs are presented. A TESTING SYSTEM FOR DRUG-INDUCED PERIPHERAL NEUROPATHY IN MICE
(203) Richard
J.R.
Johnson, M.D., and Raymond Drechsel, A.A.S.
Department of Radiation Medicine, Roswell Park Memorial Institute, 666 Elm St,, Buffalo, NY 14263 The effectiveness of electron affinic drugs such as misonidazole as oxygen sensitizers depends on their drug enhancement/toxicity ratio. Although toxicity in the mouse may be determined as a LD-50 dose with the animal maintained at a known temperature, there is no evidence at the present time that the LD-50 dose either obtained under standard laboratory conditions when the animals become profoundly haperthermic (3O'C) or the lower LD-50 obtained with theanimals maintained at 37 C, is related to peripheral neuropathy in mouse or man. An automated mice testing system has been developed which tests the coordination of the mouse extremities by counting the number of times per day that mice completely or incompletely negotiate a rotating rod connecting their eating and drinking area. Ratios of the LD-50 at 37'C for metronidazole and misonidazole are compared with the total dose of drug administered in four daily fractions required to produce a 50% coordination defect in the animals (CD-50) during a two-month follow-up period. The relationship between the CD-50 and the oxygen sensitizer enhancement factor for the two drugs will be presented.
(204)
15 YEARS EXPERIENCE WITH CARCINOMA OF THE ENDOMETRIUM S. Kalnicki, S.G. Ariathurai, F. Mincer, C. Botstein, G. Zacharopoulos Montefiore Hospital and Medical Center, Bronx, NY 10467
From 1361-1976, 151 patients with carcinoma of the endometrium were reviewed. Of these, 67 patients were treated pre-operatively, Forty-five patients were treated definitively by radiotherapy. Eleven patients were treated for local recurrence (l-10 years) following primary surgery. Only one patient with very advanced disease was treated for palliation. The remaining 27 patients were treated post-operatively.
In the analysis of this material, the following points will be emphasized:
1. The efficacy of external vs. intracavitary radiotherapy as a pre-operative method 2. The advantages of Simon afterloading Cesium 137 microsources against Heyman's capsules with Radium. This experience will reflect the changing management of endometrial carcinoma in a general hospital. The course, results and complications in all cases will be analyzed.
218
(203) Richard
J.R.
Johnson, M.D., and Raymond Drechsel, A.A.S.
Department of Radiation Medicine, Roswell Park Memorial Institute, 666 Elm St,, Buffalo, NY 14263 The effectiveness of electron affinic drugs such as misonidazole as oxygen sensitizers depends on their drug enhancement/toxicity ratio. Although toxicity in the mouse may be determined as a LD-50 dose with the animal maintained at a known temperature, there is no evidence at the present time that the LD-50 dose either obtained under standard laboratory conditions when the animals become profoundly haperthermic (3O'C) or the lower LD-50 obtained with theanimals maintained at 37 C, is related to peripheral neuropathy in mouse or man. An automated mice testing system has been developed which tests the coordination of the mouse extremities by counting the number of times per day that mice completely or incompletely negotiate a rotating rod connecting their eating and drinking area. Ratios of the LD-50 at 37'C for metronidazole and misonidazole are compared with the total dose of drug administered in four daily fractions required to produce a 50% coordination defect in the animals (CD-50) during a two-month follow-up period. The relationship between the CD-50 and the oxygen sensitizer enhancement factor for the two drugs will be presented.
(204)
15 YEARS EXPERIENCE WITH CARCINOMA OF THE ENDOMETRIUM S. Kalnicki, S.G. Ariathurai, F. Mincer, C. Botstein, G. Zacharopoulos Montefiore Hospital and Medical Center, Bronx, NY 10467
From 1361-1976, 151 patients with carcinoma of the endometrium were reviewed. Of these, 67 patients were treated pre-operatively, Forty-five patients were treated definitively by radiotherapy. Eleven patients were treated for local recurrence (l-10 years) following primary surgery. Only one patient with very advanced disease was treated for palliation. The remaining 27 patients were treated post-operatively.
In the analysis of this material, the following points will be emphasized:
1. The efficacy of external vs. intracavitary radiotherapy as a pre-operative method 2. The advantages of Simon afterloading Cesium 137 microsources against Heyman's capsules with Radium. This experience will reflect the changing management of endometrial carcinoma in a general hospital. The course, results and complications in all cases will be analyzed.
218