A014 Calcium channel blocker isradipine infusion induces the acetylcholine- vasodilation in hypertensive patients

A014 Calcium channel blocker isradipine infusion induces the acetylcholine- vasodilation in hypertensive patients

A 1 J 1 N 9 4 PH 2 9 - 8 A A- P 1 O VP R O O I F nR E 8L LS d . o a A A L L V D P C D L L A O A E A A I A S T G B S e N a R‘ e M...

131KB Sizes 0 Downloads 37 Views

A

1

J

1

N 9 4 PH

2

9

-

8

A

A-

P

1 O VP

R

O O I F nR

E

8L

LS d

. o

a

A

A L L V D P C

D L L A O A E A A I A S T G B S e N a R‘ e M 1 C lM

T CO RH CL E A T PH D E P a l Gn N r U i ea

O M d

WA O C LN C E ES B Y B L I CK TH A OU I AR LH O A TS P T Rn ea n M iC ’ vSi I dl V i M n D M U t d S n tC s h v i O

M P I C e s a i a e f a L c ( u H t e a h t s t f t e l t c c o t b t e a s t a a N v H ( m s ( w a f o m f d ( m H 5 n ( 1 l m m ( y w a p v d a e L ( m E v w T e r a ( Y t o h d r i “ a m m p c e F v f b f ( m v p c f b i A ( 1 p x5 m e M f v ( F a 1 i a f v m u e m S r L 3 ( 1 m O a T d f 1 8 ( H t r A ( 2 4 2 3 4 s n s m P F ( 5 m w s T w r a o S t w i A v w s i o t e p a d L r T r T S p o i L s c p a s t c c a a f m f d t K C

W

T

e

S

r

a

I

(

t

y

m

i S

P

c

i

m 3

2 2 *

. 1

i

,

S CR I T A IE I P R I NO L L LG L A -G M E I D A N I ME EI VN R T CE C F PA I L EI R OO NN T i mr l l e e tt n n C S O p ae R M l o eS l i e Cl “ C I ea i i eR dc c r a t e o s t m p d n w c c b L i e v n n p t h T a n t s w w I n i m p t O e a e w i ~ S ~ h T r O g f v a . o ( w

.

e d ar

(

r

,

f

5 m

a

s d

I

i a p

f

F

f

(

D

b

f

each

( F 0 b p K

D

\

i

(

T a

a t

S

(

1 rein, b

d

t

n

a

b

t

3

n a

were ( a

3 n

a

( p 2

r

a 8o

i a m C

9 m

s

h

r

1o

F

nI

df c

v

a

m i

p

9 + I

i

I A

i m t

a n

l

i

i

i

A 1 l

5

5

to

w

4



0 for h

c

w

A

w

a

(

D

b

4 d

AcM

e e

e Ach2

( P n

e

@nin,

AZhl

7 (

( w

1

t

t

i

p

i

e

i

S i

W C e

A

A

c

b

r t

h

v

h

n

i

r

c

A

A V N M

A

S R G P

A P

M

&C S

L

S d d

U b

h r

f

A a Q

R

D G

s i

S

f m

s r

I}

nitric oxide,

nitrosothiols,

P II E E CR K U 7 D

r a

dilate small

p s

me P,”ue,!e,,,,”e .Iute ,, Ol,er, um%,uled w,,,, t membak anorma!it,es ancte”ldence ISDoIntInQtoelev@ed @o.rno homo..v,ie(n [I CY,) osa tisk f,~cio, f“, :. O,LWO,Y mtervd,sease and Gthe,OSC(e,OSiSHCVS,o s.ltur.conto,”!”a mmn’cacid, .0. exert atcwc effect o; endothella cells 0. me ate, h“nd, e“rt”!hel,!,m.de, !v+ w,” (F,OIWc!,. Re, 56816, 19851 mUVPICl” a c“rd,o.osculal WOteC*l.e effecl Sir,ce tllgtl d!el”r” (r”.l<).e corrl,LJr T!Pl!or, ,r,d.. ed hvwrl.sullnemla. hvwartridvceridemlo and hvm=tensio. o ‘o st”ciYo” ?he effect otofr.c!me.<,ch deto” HC”SCmd o kmi. Ie.e!. was undertake”

vasxfilation

A TR ’

VH

I NO

7 A

EU ’

h n

4

e

e i o

r n

u

i

o

fc,~,,,ale .( g b + “ I enriched dlel fo( 4 -ks, o%rwneters measured beforeo a“d die, the d,et included, blcccl Pressure. fmi,”g !.s.11., Iriglycerldes, Iicw le..3 o.d ki.1. releos,”g .apablll!v in Cardlovosc”lar t,s,ues

n WA)

n

a

me rewlts, Us’axpecled, 51,0Wlt>ol blood Vce.,.re, level of fmtl”.a insulin a.e lrigwe,,de$ were =11,“creased i“ resw”se to the d,et. Slocd we.$”re rose from 120:5 to 148,8 mm)lg (P:O.O1j: fati”g i“sulfn rose from 1 9?0 4 i ,07. 1,2 ~rno [Pe h“wrlemion ger,er”tec In the mcde and exe!l 0 Inotechve role duriw the Clwdopment ofcardiovcmculor disorders assc.daled wllhdiotetes rnwtus Key Words: ki”i”s, diabetes rnellit.s, hwerhomccvsjei.emb.

Key Words:

’ I N

UL

H. NoIIv *, T. Darniani, R. Miatello, D. Abate. School of Medicine and CX3NICET,Mendoza Argentina. t -

b

results support the concept that L- and D- nitrosocysteine arteries in vitro a d O f

e

I

-

m p g c v s d g i a N a s r s f L h b r t C t e v r t s S S m a ( d 3 i f 2 N Z W r a p a w m m a s v m a s m a ( d 3 f 7 w d f r k c d A r n a w p w 3 n A t c r ap ( 5r c c c e I n ( D l 1 w p A t m w a w c w 3 n a ac c t o i o r a a S c c v w s d e E ( 6 +0 vL 6 A0 I W m r ( 7 +6 vL ~ 6 P “ W r a a D. Sn c c v w s d e E ( 5 i 0 vL 5 +0 0 W n m r ( 8I% + vL + 5 P ;n W T

f t

H RI

h

e

c

s f S

A

H

c

a

K F

I

~rienslo”

n i

i

t e