- Email: [email protected]
A034 Modulation of central vasopressin by blockade of the renin-angiotensin system in left ventricular hypertrophy
A
1
J
A
1
N 9 4 PH
2
9
P -
V8
A O P
aA - e
t VV i R P p S1 e O
do TaE Oe
I e saA R n - E3L AoL cd n
p.
A
C O A F NI ( G F I M HA OE T V C E UB N T S E ) IS TI R V K C E R OE E I N ( A D P O T H T SL NN T L I N 1A 1 H FM DE G R a MP I O DN S P AH Y I NK K C G NT E O S ) a P B Tf h M NI I H U C Y ( M TA O I CO B L IST a LC Oa Ir LIZ+ s U T + C I s s A I VSMC’S O W A S B R J B a ~ o H S sa r n v a K b aN I v h ne R Z iD o M m a H l e y i p ed c ~ e ri h mw t nn i s’ i .n h t n cae p a Ih i vve t l t ersns e T s W M C H ao T A U I l n o t im s f rr a ot s o i i en e c b t r s ( W s t e o A at E o pf or u of l ld h c ei I f ni Tv ec l re at et d t a c ( V o f y W Sb a S b tt M o r r aw e L d n (Hn o i ’ 0 h on e S aC i u a Kf b o o h yW a s p tn r oe P at r n d s he l i K s ni o n t ee n t e sl go u e L t h tra/+ w a C ( i t m F o a aeo E a a m c cT d h2 A n i T ni iM + s l p A ( 1 v 1 p s p A V f a o y W S a S o( I rM o r C lI u tK o n H ’ an -. S T w r l t o h b O w w g i p ce f 4 h r Tr u e e i o l o k m ut r o sa w h u r r ) r e p A ( 2 p l 2 w i w A n( e .u p i 0e e c en o E0c lM b tT1t a s pl v 1sb M t-a r e’ n ( n V 0w a i i. St p n M 1 s t 0 r rc eM t l t d - u e L w Ca1b ) s w sh r a 0 o v c o o aaP ni – cc nr e h ne he i tA cl ir b er oaK t ba ri t o t t n f sh A i i ui a 1t rl s ( ( n E a AC 0c am d . ha M s a e uwT on cr I -c ) k1 s)e ( n on v Cm cr A dw pnee i d e e o nt i p h h ni ae c y o et m h d r en a i n t tt D T s a t o A a E ci w s N m t p t i m u hne i ( ( la amA vn an (t T ma wl i t i oh l t. i S a W I a n o C s cm uK rc H p n a u T rY ws r en i e s nnR t ( po n e sh t s a t o E a iA c i V mf t c Sl h dsi a v rM T v n tt I h i oa C r t oe y c S v vo wR b HC W a f S H V f o S r S wH f K n t e mr M e e o Yr ’ Me l i w E nw m s c t tui u si n bcob nh Te p a i d pi t t b hdrt r ie i t db A a A r t r C hE n + e o C B A a Ef i f o Tc t d a e r eL s t w n a T e w i t + c cl T a i al i on C c n a t A (d o c r u m a r aI a e + e rD s d A G p gc te a v s a a a 1 a b f C l a r b 0 e se ce m p vite + li n dv % ss g rn pa e p ov e u ep l0v t c on a t c l oo E ( n wt l cA 3eh ho a t 0 t a r c T wu af ta m n t Ig ei oh M L t f F m M mb T s r wle ( n r E e as m e o1i i x o et r 0i f g re n 0a ) l u s a c A a a V f S a W S e o E o KC rM f Y H C f n . a o T ’ e hS+ c n t n T c m eT i s c t At V o o S sr m t o m ac rt lM e e a s r t vpi S s n m tgu oH c s i nT a tb w E a m s t Pu i oc eo h bb- K t p r i i h il1r A e i r i am Ap r t t W E o A a E o S f a W a K f e n TY H c n K r t o . n t lL r e s i t p ri s e h m y t p K W i e v h ra b tn s a s i erv K W a 2 en 1 v gn P i d o os t t e h m n K e s l i c
T E ( C
E
A C E H S
H
AO E R AR N C A E DT E OC R I T E Z A H P T E N I T O L N O SN I P Y D K A O NB O IT T R aH HD E C E c NL S I I Ek I N N K R K Ar S D aB c a . R o h s m k e esee e J m rr e e an * my o . , Bc l F n nR M P e D M o e U d y et e nc o i i l p id oc i n a i t . v, c n S t p k s m o s i iw i t h r m n d i h a ac l i an i c r r h ni n e e t t e h k i m b c i fu x o e nd n o t ms r n a a i n s ed opa l e a y n r t na T kr h a a ia h n ro o i sd w m p n l emi i a e re v n yt d e e g ss i d r o l c o e a mr f p ( oa d l ac i e . c A ai r t ut n i l R go u n ut s a r e en sn m d p dam y ou Ea t h sc l h g ae e t l i d T a( eT d a i i r i s m c b i p o i n n oo on s u d rfu i fo t f t r u l a ci m i cn ao i tt n i f i t p uk i a o an p v iW cr r a t d h t e ic il s n i a o e n eb s n n t i h En r d ve a ep e r i e rs c e t o n ei f p g s po e na rr t t i e t e o m f pe r g ma o p l t b r e a ro r i mp c a n s e i on n i r s le a nu s l u W a i En s b vf yi eg l rn ss l t t eo o i h g s m l s ae ea t hs er e t oi ( o nc I l u l en M m cl l ee t a C u a i m c ed dG l nu o le c rl i r d n rD m w f e t h E r m w B eoo 1b e c ra eu a i p n r v tn e. t o s p a I om3 * 4r p U Bo om l s t o n /3 e l i mQ i / +0 p . 3 g 1 ( M as b o E pr 1 wl f e t e c o 2 0c ) eo c i p hT ” t fk u o i e 3 r5 a 3 o t r a E er ( o 01ce 1 0 ec t pe r 7 T tp B a . ot . ro . f P moo m a e op m ibl rm l / L p p I 4 m t 5 rp t l e3 / i n a l g s E r w B heo 1 * 0 p c p o em i r p w o ~o t . . le t o t r/ d e a b o 1 t 7 p I t p o mB ( rO o n Q e 1 ”l s h e/ 5 1 n L d w f t a p9 o t po r ar E he o o xu4c i e m a t anp rt Y T t e ae l do r ( e1 + 0 p c p & 1e m+ 2 r p oo t B . .o tl r e3 / s i . m p B (mO ao E a o E s” T l eB 5 T/ n r L M ent )c A a e) . i lg ea a p l oa e p ei i k t sr n l o l l r a b n a E r t go c o cm pn l te u , m P e m am w e f t bp a m r i ob l a e l rn l m e a u a s nr or . en e c x E r c w o ep l s f c u nr T h es o t ip t v rb t i a Ee o a l i r c bey o p v a Ia c te c p o p o es i Mn r h s l lf n e i l e v l rC u a u l mi s ~ i f t I c p i h Ei nor eh g M e h d s - c l a si ea f C Tf n ep l i t n sg m t d e e o E iT d w a s f iu i h a rg f h tn e T i ee i a t f n i ci rg c t i E s m b f e Iy c( f dn1 er t p e M e h 2 n e ed l e s C n s 9t i c b yd o / ei n t mo h t eo n/h i u s e n mt s r) l g a i p p N E sg r f i p gr s S lo v eo p o e r l i rm s r cea o a h rn t ip t u l ae e nl c y m a t r rga p es a Ea u j n a T p es i p pr c i nn r l t n e t as id s n uo t l s r i i cn c t t a r wo i b r a l cm oe ec ba sl i s i l t i e u u ml n n a m t ee ne a v m b m e e i m r f e aa a f i on p en a a at c a m ts r i n i i n d l l t f r u a an n s c p t t l i a o n n e t K w p k E s oo r i y e r nr d ec t c nd eh i ep e s s t n y i yo :
1
J
A
1
N 9 4 PH
2
9
P -
V8
A O P
aA - e
t VV i R P p S1 e O
do TaE Oe
I e saA R n - E3L AoL cd n
p.
A
C O A F NI ( G F I M HA OE T V C E UB N T S E ) IS TI R V K C E R OE E I N ( A D P O T H T SL NN T L I N 1A 1 H FM DE G R a MP I O DN S P AH Y I NK K C G NT E O S ) a P B Tf h M NI I H U C Y ( M TA O I CO B L IST a LC Oa Ir LIZ+ s U T + C I s s A I VSMC’S O W A S B R J B a ~ o H S sa r n v a K b aN I v h ne R Z iD o M m a H l e y i p ed c ~ e ri h mw t nn i s’ i .n h t n cae p a Ih i vve t l t ersns e T s W M C H ao T A U I l n o t im s f rr a ot s o i i en e c b t r s ( W s t e o A at E o pf or u of l ld h c ei I f ni Tv ec l re at et d t a c ( V o f y W Sb a S b tt M o r r aw e L d n (Hn o i ’ 0 h on e S aC i u a Kf b o o h yW a s p tn r oe P at r n d s he l i K s ni o n t ee n t e sl go u e L t h tra/+ w a C ( i t m F o a aeo E a a m c cT d h2 A n i T ni iM + s l p A ( 1 v 1 p s p A V f a o y W S a S o( I rM o r C lI u tK o n H ’ an -. S T w r l t o h b O w w g i p ce f 4 h r Tr u e e i o l o k m ut r o sa w h u r r ) r e p A ( 2 p l 2 w i w A n( e .u p i 0e e c en o E0c lM b tT1t a s pl v 1sb M t-a r e’ n ( n V 0w a i i. St p n M 1 s t 0 r rc eM t l t d - u e L w Ca1b ) s w sh r a 0 o v c o o aaP ni – cc nr e h ne he i tA cl ir b er oaK t ba ri t o t t n f sh A i i ui a 1t rl s ( ( n E a AC 0c am d . ha M s a e uwT on cr I -c ) k1 s)e ( n on v Cm cr A dw pnee i d e e o nt i p h h ni ae c y o et m h d r en a i n t tt D T s a t o A a E ci w s N m t p t i m u hne i ( ( la amA vn an (t T ma wl i t i oh l t. i S a W I a n o C s cm uK rc H p n a u T rY ws r en i e s nnR t ( po n e sh t s a t o E a iA c i V mf t c Sl h dsi a v rM T v n tt I h i oa C r t oe y c S v vo wR b HC W a f S H V f o S r S wH f K n t e mr M e e o Yr ’ Me l i w E nw m s c t tui u si n bcob nh Te p a i d pi t t b hdrt r ie i t db A a A r t r C hE n + e o C B A a Ef i f o Tc t d a e r eL s t w n a T e w i t + c cl T a i al i on C c n a t A (d o c r u m a r aI a e + e rD s d A G p gc te a v s a a a 1 a b f C l a r b 0 e se ce m p vite + li n dv % ss g rn pa e p ov e u ep l0v t c on a t c l oo E ( n wt l cA 3eh ho a t 0 t a r c T wu af ta m n t Ig ei oh M L t f F m M mb T s r wle ( n r E e as m e o1i i x o et r 0i f g re n 0a ) l u s a c A a a V f S a W S e o E o KC rM f Y H C f n . a o T ’ e hS+ c n t n T c m eT i s c t At V o o S sr m t o m ac rt lM e e a s r t vpi S s n m tgu oH c s i nT a tb w E a m s t Pu i oc eo h bb- K t p r i i h il1r A e i r i am Ap r t t W E o A a E o S f a W a K f e n TY H c n K r t o . n t lL r e s i t p ri s e h m y t p K W i e v h ra b tn s a s i erv K W a 2 en 1 v gn P i d o os t t e h m n K e s l i c
T E ( C
E
A C E H S
H
AO E R AR N C A E DT E OC R I T E Z A H P T E N I T O L N O SN I P Y D K A O NB O IT T R aH HD E C E c NL S I I Ek I N N K R K Ar S D aB c a . R o h s m k e esee e J m rr e e an * my o . , Bc l F n nR M P e D M o e U d y et e nc o i i l p id oc i n a i t . v, c n S t p k s m o s i iw i t h r m n d i h a ac l i an i c r r h ni n e e t t e h k i m b c i fu x o e nd n o t ms r n a a i n s ed opa l e a y n r t na T kr h a a ia h n ro o i sd w m p n l emi i a e re v n yt d e e g ss i d r o l c o e a mr f p ( oa d l ac i e . c A ai r t ut n i l R go u n ut s a r e en sn m d p dam y ou Ea t h sc l h g ae e t l i d T a( eT d a i i r i s m c b i p o i n n oo on s u d rfu i fo t f t r u l a ci m i cn ao i tt n i f i t p uk i a o an p v iW cr r a t d h t e ic il s n i a o e n eb s n n t i h En r d ve a ep e r i e rs c e t o n ei f p g s po e na rr t t i e t e o m f pe r g ma o p l t b r e a ro r i mp c a n s e i on n i r s le a nu s l u W a i En s b vf yi eg l rn ss l t t eo o i h g s m l s ae ea t hs er e t oi ( o nc I l u l en M m cl l ee t a C u a i m c ed dG l nu o le c rl i r d n rD m w f e t h E r m w B eoo 1b e c ra eu a i p n r v tn e. t o s p a I om3 * 4r p U Bo om l s t o n /3 e l i mQ i / +0 p . 3 g 1 ( M as b o E pr 1 wl f e t e c o 2 0c ) eo c i p hT ” t fk u o i e 3 r5 a 3 o t r a E er ( o 01ce 1 0 ec t pe r 7 T tp B a . ot . ro . f P moo m a e op m ibl rm l / L p p I 4 m t 5 rp t l e3 / i n a l g s E r w B heo 1 * 0 p c p o em i r p w o ~o t . . le t o t r/ d e a b o 1 t 7 p I t p o mB ( rO o n Q e 1 ”l s h e/ 5 1 n L d w f t a p9 o t po r ar E he o o xu4c i e m a t anp rt Y T t e ae l do r ( e1 + 0 p c p & 1e m+ 2 r p oo t B . .o tl r e3 / s i . m p B (mO ao E a o E s” T l eB 5 T/ n r L M ent )c A a e) . i lg ea a p l oa e p ei i k t sr n l o l l r a b n a E r t go c o cm pn l te u , m P e m am w e f t bp a m r i ob l a e l rn l m e a u a s nr or . en e c x E r c w o ep l s f c u nr T h es o t ip t v rb t i a Ee o a l i r c bey o p v a Ia c te c p o p o es i Mn r h s l lf n e i l e v l rC u a u l mi s ~ i f t I c p i h Ei nor eh g M e h d s - c l a si ea f C Tf n ep l i t n sg m t d e e o E iT d w a s f iu i h a rg f h tn e T i ee i a t f n i ci rg c t i E s m b f e Iy c( f dn1 er t p e M e h 2 n e ed l e s C n s 9t i c b yd o / ei n t mo h t eo n/h i u s e n mt s r) l g a i p p N E sg r f i p gr s S lo v eo p o e r l i rm s r cea o a h rn t ip t u l ae e nl c y m a t r rga p es a Ea u j n a T p es i p pr c i nn r l t n e t as id s n uo t l s r i i cn c t t a r wo i b r a l cm oe ec ba sl i s i l t i e u u ml n n a m t ee ne a v m b m e e i m r f e aa a f i on p en a a at c a m ts r i n i i n d l l t f r u a an n s c p t t l i a o n n e t K w p k E s oo r i y e r nr d ec t c nd eh i ep e s s t n y i yo :