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ABO blood groups and pulmonary tuberculosis
322
Tubwc,k. ( 1970). 51, 332
NOTES
ABO BLOOD
GROUPS AND PULMONARY
TUBERCULOSIS
SUMMARY The ABO blood groups of 1,600 patients with pulmonary tuberculosis were compared with those of 3,799 apparently healthy people from the same area. Among the tuberculous patients 16.0% were of group AB compared with 7.2% among the controls, a significant difference.
Les groupes sanguins A, B, 0 de 1.600 malades presentant une tuberculose pulmonaire ont et& compares avec les groupes de 3.799 sujets apparemment en bonne Sante, habitant la mCme region. Parmi les malades tuberculeux, 16% ttaient du groupe AB, tandis que parmi les sujets temoins 7,2 % seulement Ctaient de ce groupe. Cette difference est significative.
RESUMEN Se compararon 10s grupos sanguineos A,B y 0 de 1.600 pacientes con tuberculosis pulmonar con 10s de 3799 individuos sanos de la misma area. Entre 10s pacientes tuberculosos el 16% eran de1 grupo AB, comparados con un 7,2x entre 10s controles, una diferencia significativa.
ZUSAMMENFASSUNG Die ABO=Blutgruppen von 1600 Patienten mit Lungentuberkulose wurden verglichen mit denen von 3799 offensichtlich gesunden Personen aus der gleichen Gegend. Unter den Tuberkulijsen fanden sich 16,0x der Gruppe AB gegen 7,2x unter den Kontrollen; diese Differenz ist signifikant. Introduction An association between ABO blood groups and various diseases has been observed during the last two decades. It has been inferred that persons belonging to the different Landsteiner groups differ in their susceptibility to certain diseases in adult life (Jain, 1968). The relationship between respiratory diseases and ABO blood groups has been studied by Streng and Ryti (1927) who observed a shortage of group 0 among tuberculous patients. Struthers (1951) found that there was an excess of group A children under two years of age who had died from bronchopneumonia in a Glasgow Hospital. In view of these observations, it was decided to carry out a survey in this part of India to find out whether there was an association between blood groups and pulmonary tuberculosis. Material
and Method
The blood groups of 1,600 patients with pulmonary tuberculosis confirmed by sputum examination and x-ray were extracted from the records of the Hospital for Chest & Tuberculosis, Jaipur
BLOOD
323
GROUPS
TABLE I.--BLOOD GROUP FREQUENCIES IN PATIENTSWITH PULMONARYTUBERCULOSIS ANI) APPARENTLYHEALTHYINDIVIDUALSFROMTHE SAMEAREA _ Blood group
Pulmonary tuberculosis
Control group
A
308
(I 9.2 %)
879
B 0 AB
576 460 256
(36.0 %) (28.8%) (26.0%)
1346 1300 274
Total
1600
(100%)
3799
D$erence
(23.2%)
’
(35.4 %,) (34.2%) (7.2x)
~
(100%)
i I_
~
of percentages -4.0 +0.6 -5.4 -t8.8
-
covering
the years 1964-1969. The control group was the same as the one used for previous investigations (Jain, 1968; Sharma, Jain and Dave, 1969). It consisted of apparently healthy individuals from the same geographical area as the tuberculous patients. Professional blood donors were not included. The blood grouping was done by the usual methods. The same technique was used for the tuberculous patients and the controls and the grouping was done in the same laboratory. Results The observations are shown in Table I together with the difference in the percentages between the tuberculous and the control groups. Out of the 1,600 patients 308 (19.2%) were group A, 576 (36.0%) group B, 460 (28.8 %) group 0 and 256 (16.0%) group AB. It is evident that there was a higher incidence of group AB among the tuberculous patients than the controls. The difference between the tuberculous patients and the apparently healthy individuals in the distribution of blood groups is significant (P < OXlOl).This suggests that there may be some association between blood group and pulmonary tuberculosis. Further investigation is warranted. R. C. JAIN* Department of Pathology, S.M.S. Medical College, Jaipur (Rajasthan). India. REFERENCES JAIN,R. C. (1968). ABO blood groups in relation to breast cancer. Current Medical Practice, 12, 498. SHARMA,D. C., JAIN, R. C. & DAVE, S. S. (1969). Relation between duodenal ulcer and blood group in people of the Udaipur region of India. Gut, 10, 75. STRENG, 0. & RYTI, E. (1927). Quoted by Allan, T. M. (1955). Blood groups and disease. Brirish Medical Journal, 2, 1206. STRUTHERS,D. (1951). ABO blood groups of infants and children dying in the West of Scotland (1949-1951). British Journal of Social Medicine, 5, 223.
* Present address: 131 Bakht Sagar Road, Nehru Park, Jodhpur (Raj), India.
H
Tubwc,k. ( 1970). 51, 332
NOTES
ABO BLOOD
GROUPS AND PULMONARY
TUBERCULOSIS
SUMMARY The ABO blood groups of 1,600 patients with pulmonary tuberculosis were compared with those of 3,799 apparently healthy people from the same area. Among the tuberculous patients 16.0% were of group AB compared with 7.2% among the controls, a significant difference.
Les groupes sanguins A, B, 0 de 1.600 malades presentant une tuberculose pulmonaire ont et& compares avec les groupes de 3.799 sujets apparemment en bonne Sante, habitant la mCme region. Parmi les malades tuberculeux, 16% ttaient du groupe AB, tandis que parmi les sujets temoins 7,2 % seulement Ctaient de ce groupe. Cette difference est significative.
RESUMEN Se compararon 10s grupos sanguineos A,B y 0 de 1.600 pacientes con tuberculosis pulmonar con 10s de 3799 individuos sanos de la misma area. Entre 10s pacientes tuberculosos el 16% eran de1 grupo AB, comparados con un 7,2x entre 10s controles, una diferencia significativa.
ZUSAMMENFASSUNG Die ABO=Blutgruppen von 1600 Patienten mit Lungentuberkulose wurden verglichen mit denen von 3799 offensichtlich gesunden Personen aus der gleichen Gegend. Unter den Tuberkulijsen fanden sich 16,0x der Gruppe AB gegen 7,2x unter den Kontrollen; diese Differenz ist signifikant. Introduction An association between ABO blood groups and various diseases has been observed during the last two decades. It has been inferred that persons belonging to the different Landsteiner groups differ in their susceptibility to certain diseases in adult life (Jain, 1968). The relationship between respiratory diseases and ABO blood groups has been studied by Streng and Ryti (1927) who observed a shortage of group 0 among tuberculous patients. Struthers (1951) found that there was an excess of group A children under two years of age who had died from bronchopneumonia in a Glasgow Hospital. In view of these observations, it was decided to carry out a survey in this part of India to find out whether there was an association between blood groups and pulmonary tuberculosis. Material
and Method
The blood groups of 1,600 patients with pulmonary tuberculosis confirmed by sputum examination and x-ray were extracted from the records of the Hospital for Chest & Tuberculosis, Jaipur
BLOOD
323
GROUPS
TABLE I.--BLOOD GROUP FREQUENCIES IN PATIENTSWITH PULMONARYTUBERCULOSIS ANI) APPARENTLYHEALTHYINDIVIDUALSFROMTHE SAMEAREA _ Blood group
Pulmonary tuberculosis
Control group
A
308
(I 9.2 %)
879
B 0 AB
576 460 256
(36.0 %) (28.8%) (26.0%)
1346 1300 274
Total
1600
(100%)
3799
D$erence
(23.2%)
’
(35.4 %,) (34.2%) (7.2x)
~
(100%)
i I_
~
of percentages -4.0 +0.6 -5.4 -t8.8
-
covering
the years 1964-1969. The control group was the same as the one used for previous investigations (Jain, 1968; Sharma, Jain and Dave, 1969). It consisted of apparently healthy individuals from the same geographical area as the tuberculous patients. Professional blood donors were not included. The blood grouping was done by the usual methods. The same technique was used for the tuberculous patients and the controls and the grouping was done in the same laboratory. Results The observations are shown in Table I together with the difference in the percentages between the tuberculous and the control groups. Out of the 1,600 patients 308 (19.2%) were group A, 576 (36.0%) group B, 460 (28.8 %) group 0 and 256 (16.0%) group AB. It is evident that there was a higher incidence of group AB among the tuberculous patients than the controls. The difference between the tuberculous patients and the apparently healthy individuals in the distribution of blood groups is significant (P < OXlOl).This suggests that there may be some association between blood group and pulmonary tuberculosis. Further investigation is warranted. R. C. JAIN* Department of Pathology, S.M.S. Medical College, Jaipur (Rajasthan). India. REFERENCES JAIN,R. C. (1968). ABO blood groups in relation to breast cancer. Current Medical Practice, 12, 498. SHARMA,D. C., JAIN, R. C. & DAVE, S. S. (1969). Relation between duodenal ulcer and blood group in people of the Udaipur region of India. Gut, 10, 75. STRENG, 0. & RYTI, E. (1927). Quoted by Allan, T. M. (1955). Blood groups and disease. Brirish Medical Journal, 2, 1206. STRUTHERS,D. (1951). ABO blood groups of infants and children dying in the West of Scotland (1949-1951). British Journal of Social Medicine, 5, 223.
* Present address: 131 Bakht Sagar Road, Nehru Park, Jodhpur (Raj), India.
H