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Absence of slicing — tissue metabolism investigated
T1BS - February 1983
74 data relating to renomedullary lipogenesis, renal ammonia metabolism, renal ketone body utilization, aldosterone effects on the kidney and its metabolism by renal tissue, tubular binding sites of aldosterone, quantitative histochemistry of various parts of
the nephron, and renal phosphorus utilization. The chapters contain much useful information. The strength of the book appears to be the emphasis of current trends in research in renal metabolism.
A b s e n c e o f slicing - tissue m e t a b o l i s m investigated Non-invasive Probes of Tissue Metabolism
This book is based on a symposium held in June 1980 at the New Orleans meeting of the American Society of Biological Chemists. According to the editor the term noninvasive is taken to mean that the sample organism is not 'sliced up' in order to obtain the results. This has resulted in the exclusion of fluoresence probe techniques and the use of [x4C]2-deoxyglucose to study brain metabolism. However, the term noninvasive is somewhat misleading in that one chapter describes the use of fluorescence spectroscopy to measure the redox state of excised corneas at liquid nitrogen temperature, while another discusses the application of NMR to study gluconeogenesis in
isolate perfused livers. In seven of the ten chapters in this book NMR is the technique discussed, and five of these deal mainly with 3~p NMR. For this reason the editor briefly reviews the NMR technique in the introduction. However, it should be pointed out that extensive knowledge of NMR is not necessary to understand most of the material found in this volume. Applications that are covered include: 3ap NMR measurements of intracellular pH, the phosphorus metabolism of the intact heart and whole animals (using surface coils); aap and ~3C NMR studies of the protozoan Acanthamoeba castellani, and ~3C NMR studies of gluconeogenesis in hepatocytes and perfused mouse liver. The chapter on the NMR of flowing blood from a dog is of interest since it points out that other nuclei, e.g. 23Na, ~gF (from halogenated anesthetics) can be studied by this technique.
Books Received
reins Academic Press, 1982. £19.211/$39.511 (viii
edited by Jack S. Cohen, John Wiley and Sons, 1982. £36.50 (xiv + 270 pages) ISBN 0 471 08893 5
Review copies of the following books have been received. Books which have been reviewed in full in
TIBS are not included. Books Received - List 4, continued R. J. Hamilton and P. A. Sewell Introduction l b High I'erfi~rmance Liquid Chromatography 2nd edn, Chapman and Hall Ltd, 1982. £13.00 (xi + 248 pages) ISBN 1) 421 23430 0 E. W. Johns (ed.) 7"he t t M G (hromosomal Pro-
251 pages) ISBN 0 12 3860504 Wendell W. Leavitt (ed.)Advances in k.xperimental Medicine and Biology Vol. 138 ttormones and (ancer Plenum Press. 1982. $49.50 (ix + 421 pages) ISBN 1) 306 40831 7 Gerald Litwack (ed.) Biochemkal Actions of ttormones Vol. IX Academic Press. 1982. £42.(X) (xiii 362 pages) ISBN 0 12 4528119 0 John J. Marchalonis and Michael G. Hanna (cds) ('ancer Biology Reviews Vol. 3 Marcel Dekker Inc.,
This book is intended for and recommended to all individuals who relate to renal physiology and biochemistry. PAUL L. WOLF
Paul L. Wolf is Professor o f Pathology at the University Hospital, UCSD, 225 W. Dickinson. San Diego, CA 92103, U.S.A.
The three remaining chapters deal with the continuous monitoring of volatile metabolites by mass spectrometry, the measurement of the redox state of the cornea by fluorescence spectroscopy and the use of positron-emitting isotopes, e.g. HC, aSF for metabolic imaging. The latter chapter, which was not part of the original symposium, is in my opinion one of the best contributions in the book. In summary, this book is a useful source of information on some current methods to study tissue metabolism non-invasively. The heavy emphasis placed on NMR merely reflects the important contribution that this technique is making to our understanding of in- vivo metabolic processes. COLIN F. CHIGNELL
Colin F. Chignell is Chief at the Laboratory o f Environmental Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 17709, U.S.A.
1982. SFr 118.(X) (x + 211 pages) ISBN 0 8247 1885 2 P. A. Mardh. K. K. Holmes, J. D. Oriel, P. Piol and J. Schachter leds) Chlarnydial ln tbctirms Elsevier Biomedical Press. 1982. D r . 136.(X) (viii + 454 pages) ISBN 0 444 81.1431 5 V. Ter Meulen, S. Siddell and H. Wege (eds)
Advances in t:xperimental Medk'ine attd Biology Vol. 142 - Biochemist O' and Biology o f ( oronaviru, s'es Plenum Press, 1981. $49.5/) (x ~ 438 pages) [SBN 0 306 40806 6
74 data relating to renomedullary lipogenesis, renal ammonia metabolism, renal ketone body utilization, aldosterone effects on the kidney and its metabolism by renal tissue, tubular binding sites of aldosterone, quantitative histochemistry of various parts of
the nephron, and renal phosphorus utilization. The chapters contain much useful information. The strength of the book appears to be the emphasis of current trends in research in renal metabolism.
A b s e n c e o f slicing - tissue m e t a b o l i s m investigated Non-invasive Probes of Tissue Metabolism
This book is based on a symposium held in June 1980 at the New Orleans meeting of the American Society of Biological Chemists. According to the editor the term noninvasive is taken to mean that the sample organism is not 'sliced up' in order to obtain the results. This has resulted in the exclusion of fluoresence probe techniques and the use of [x4C]2-deoxyglucose to study brain metabolism. However, the term noninvasive is somewhat misleading in that one chapter describes the use of fluorescence spectroscopy to measure the redox state of excised corneas at liquid nitrogen temperature, while another discusses the application of NMR to study gluconeogenesis in
isolate perfused livers. In seven of the ten chapters in this book NMR is the technique discussed, and five of these deal mainly with 3~p NMR. For this reason the editor briefly reviews the NMR technique in the introduction. However, it should be pointed out that extensive knowledge of NMR is not necessary to understand most of the material found in this volume. Applications that are covered include: 3ap NMR measurements of intracellular pH, the phosphorus metabolism of the intact heart and whole animals (using surface coils); aap and ~3C NMR studies of the protozoan Acanthamoeba castellani, and ~3C NMR studies of gluconeogenesis in hepatocytes and perfused mouse liver. The chapter on the NMR of flowing blood from a dog is of interest since it points out that other nuclei, e.g. 23Na, ~gF (from halogenated anesthetics) can be studied by this technique.
Books Received
reins Academic Press, 1982. £19.211/$39.511 (viii
edited by Jack S. Cohen, John Wiley and Sons, 1982. £36.50 (xiv + 270 pages) ISBN 0 471 08893 5
Review copies of the following books have been received. Books which have been reviewed in full in
TIBS are not included. Books Received - List 4, continued R. J. Hamilton and P. A. Sewell Introduction l b High I'erfi~rmance Liquid Chromatography 2nd edn, Chapman and Hall Ltd, 1982. £13.00 (xi + 248 pages) ISBN 1) 421 23430 0 E. W. Johns (ed.) 7"he t t M G (hromosomal Pro-
251 pages) ISBN 0 12 3860504 Wendell W. Leavitt (ed.)Advances in k.xperimental Medicine and Biology Vol. 138 ttormones and (ancer Plenum Press. 1982. $49.50 (ix + 421 pages) ISBN 1) 306 40831 7 Gerald Litwack (ed.) Biochemkal Actions of ttormones Vol. IX Academic Press. 1982. £42.(X) (xiii 362 pages) ISBN 0 12 4528119 0 John J. Marchalonis and Michael G. Hanna (cds) ('ancer Biology Reviews Vol. 3 Marcel Dekker Inc.,
This book is intended for and recommended to all individuals who relate to renal physiology and biochemistry. PAUL L. WOLF
Paul L. Wolf is Professor o f Pathology at the University Hospital, UCSD, 225 W. Dickinson. San Diego, CA 92103, U.S.A.
The three remaining chapters deal with the continuous monitoring of volatile metabolites by mass spectrometry, the measurement of the redox state of the cornea by fluorescence spectroscopy and the use of positron-emitting isotopes, e.g. HC, aSF for metabolic imaging. The latter chapter, which was not part of the original symposium, is in my opinion one of the best contributions in the book. In summary, this book is a useful source of information on some current methods to study tissue metabolism non-invasively. The heavy emphasis placed on NMR merely reflects the important contribution that this technique is making to our understanding of in- vivo metabolic processes. COLIN F. CHIGNELL
Colin F. Chignell is Chief at the Laboratory o f Environmental Biophysics, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 17709, U.S.A.
1982. SFr 118.(X) (x + 211 pages) ISBN 0 8247 1885 2 P. A. Mardh. K. K. Holmes, J. D. Oriel, P. Piol and J. Schachter leds) Chlarnydial ln tbctirms Elsevier Biomedical Press. 1982. D r . 136.(X) (viii + 454 pages) ISBN 0 444 81.1431 5 V. Ter Meulen, S. Siddell and H. Wege (eds)
Advances in t:xperimental Medk'ine attd Biology Vol. 142 - Biochemist O' and Biology o f ( oronaviru, s'es Plenum Press, 1981. $49.5/) (x ~ 438 pages) [SBN 0 306 40806 6