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Absorption studies on radioactive iron-dextran in pregnancy
\·nlume 76 ~umber·+
92G
SELECTED ABSTRACTS
The Lancet Vol. 2, Nov. 23, 1957.
Stewart, H. C., Hughes, w. H., Thomas, E. G., and Nixon, W. c. W.: Trichomonas Vaginitis: Clinical Trial of a Mixture of an Antiseptic With Local Anesthetics, p. 1028. An antipruritus cream, Locan (amethocaine gr. 1,{1, amylocaine gr. :Yb, solution of benzalkonium chloride B.P.C.m lfi'l, lactic acid gr. 1;:2, and lactose gr. 4), which has been found to have antiseptic action (Hughes, W. H., Stewart. H. C., .J. Pharm. & Pharmacol. 9: 431, 1957). 'J'his cream was fashioned into vaginal pessaries and patients with 'l'rirhomona~ ;·aginiti~ were treated by inserting a pessary twice a day for l1 days. If the infestaiion was not controlled, the period of therapy was extended for an additional 6 day~. Thix therapy was compared with the use of acetarsol pessaries (2 pessaries at night only for 14 days) and the use of one pessary containing phenylmereurie dinaphthylmethane (lion!· phonate (Pentotrane) for 14 days. In 68 incidents the infestation was controlled every time as opposed to only 47 of 12 incidents controlled by Penotrane and 54 of 79 incidents controlled by acetarsol. Neither this nor any other treatment of one partner alone can control reinfestation. K o evidence of resistance was found and this autipruritus compound, which relieve~ the intense itching quickly, contains 3 compounds all of which inhibit the organism in dtro. In addition, there is some evidence that '' Locan'' i~ efft>etive in moniliasis and this is being investigated further. llAYID
M.
KY!>D
Vol. 2, Dec. 14, 1957.
Evans, L. A. J., and Ramsey, N. W.: Absorption Studies on Radioactive Iron-Dextran in Pregnancy, p. 1192. To 7 patients (3 were admitted for termination of the pregnancy at 11, 12, and lH weeks, respectively, 2 were admitted because of anencephalus during the thirty-second and thirty-ninth weeks of pregnancy, one was admitted at 12 weeks because of an iron de· Jiciency anemia, and one was tested 2 days after a difficult delivery involving the loss of 30 ounces of blood) Fe59-dextran, produced by using Fes9CJ, as part of the starting iron solution, was given. 'l'he rate of absorption from the gluteal site was similar whether the compound had been given in one or multiple sites or in either side. Within 3 days, 50 to 60 per cent of the injected activity had left the site of the injection. After 10 days the rate of di~· appearance had been reduced to about 0.2 per cent per day but traces of activity wen• detected for 6 months. The data suggest that the material is absorbed by way of the lymphatics as shown by the much slower disappearance rate in the patient with arthritis who was partly immobilized by her disease and consequently had little muRwlar aetivity and by the fact that, in one instance at least, the Fe59 activity in the plasma did not reach a maxi· mum for 30 hours. The activity of the red blood cells steadily increased during the 7 days it was measured. Inasmuch as surface measurements of Fe'9 activity must take into aecount the rela· tively large a<•cumulation of Fe>9 that occurs in the liver and spleen between the tenth awl twentieth days after injection as well as the aceumulation in the regional lymph nodes, t.lw amount of unabsorbed material remaining at the site of injertion after the first several day,o is probably wry small. Transfer of the isotope to the fetus will he discu~sed elsewhere. DAVID M. KYI>/l
Vol. .1, Feb. 22, 1958.
McLaren, H. c., Taylor, c. W., and Attwood, M. E.: cological Practice, p. :398.
.r.
Cytological Diagnosis in Gyne-
'l'lw previously reported series (McLa1·en, II. C., Taylor, C. W., and Attwood, l\L .K: Obst. & Gynaec. Brit. Emp. 63: 801, 1956) has now been extended to include 4.250
92G
SELECTED ABSTRACTS
The Lancet Vol. 2, Nov. 23, 1957.
Stewart, H. C., Hughes, w. H., Thomas, E. G., and Nixon, W. c. W.: Trichomonas Vaginitis: Clinical Trial of a Mixture of an Antiseptic With Local Anesthetics, p. 1028. An antipruritus cream, Locan (amethocaine gr. 1,{1, amylocaine gr. :Yb, solution of benzalkonium chloride B.P.C.m lfi'l, lactic acid gr. 1;:2, and lactose gr. 4), which has been found to have antiseptic action (Hughes, W. H., Stewart. H. C., .J. Pharm. & Pharmacol. 9: 431, 1957). 'J'his cream was fashioned into vaginal pessaries and patients with 'l'rirhomona~ ;·aginiti~ were treated by inserting a pessary twice a day for l1 days. If the infestaiion was not controlled, the period of therapy was extended for an additional 6 day~. Thix therapy was compared with the use of acetarsol pessaries (2 pessaries at night only for 14 days) and the use of one pessary containing phenylmereurie dinaphthylmethane (lion!· phonate (Pentotrane) for 14 days. In 68 incidents the infestation was controlled every time as opposed to only 47 of 12 incidents controlled by Penotrane and 54 of 79 incidents controlled by acetarsol. Neither this nor any other treatment of one partner alone can control reinfestation. K o evidence of resistance was found and this autipruritus compound, which relieve~ the intense itching quickly, contains 3 compounds all of which inhibit the organism in dtro. In addition, there is some evidence that '' Locan'' i~ efft>etive in moniliasis and this is being investigated further. llAYID
M.
KY!>D
Vol. 2, Dec. 14, 1957.
Evans, L. A. J., and Ramsey, N. W.: Absorption Studies on Radioactive Iron-Dextran in Pregnancy, p. 1192. To 7 patients (3 were admitted for termination of the pregnancy at 11, 12, and lH weeks, respectively, 2 were admitted because of anencephalus during the thirty-second and thirty-ninth weeks of pregnancy, one was admitted at 12 weeks because of an iron de· Jiciency anemia, and one was tested 2 days after a difficult delivery involving the loss of 30 ounces of blood) Fe59-dextran, produced by using Fes9CJ, as part of the starting iron solution, was given. 'l'he rate of absorption from the gluteal site was similar whether the compound had been given in one or multiple sites or in either side. Within 3 days, 50 to 60 per cent of the injected activity had left the site of the injection. After 10 days the rate of di~· appearance had been reduced to about 0.2 per cent per day but traces of activity wen• detected for 6 months. The data suggest that the material is absorbed by way of the lymphatics as shown by the much slower disappearance rate in the patient with arthritis who was partly immobilized by her disease and consequently had little muRwlar aetivity and by the fact that, in one instance at least, the Fe59 activity in the plasma did not reach a maxi· mum for 30 hours. The activity of the red blood cells steadily increased during the 7 days it was measured. Inasmuch as surface measurements of Fe'9 activity must take into aecount the rela· tively large a<•cumulation of Fe>9 that occurs in the liver and spleen between the tenth awl twentieth days after injection as well as the aceumulation in the regional lymph nodes, t.lw amount of unabsorbed material remaining at the site of injertion after the first several day,o is probably wry small. Transfer of the isotope to the fetus will he discu~sed elsewhere. DAVID M. KYI>/l
Vol. .1, Feb. 22, 1958.
McLaren, H. c., Taylor, c. W., and Attwood, M. E.: cological Practice, p. :398.
.r.
Cytological Diagnosis in Gyne-
'l'lw previously reported series (McLa1·en, II. C., Taylor, C. W., and Attwood, l\L .K: Obst. & Gynaec. Brit. Emp. 63: 801, 1956) has now been extended to include 4.250