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Abstract # 3134 Prenatal LPS increases the switch selection of maternal behavior to predatory behavior in rats independently of sickness behavior
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Abstracts / Brain, Behavior, and Immunity 76 (2019) e1–e43
Abstract # 3132 LPS-induced sickness behavior during lactation induces predatory behavior instead of maternal behavior in rats T. Mendes-Lima, P.S. Rodrigues, T.B. Kirsten, M.M. Bernardi
reactivation was associated with shorter telomeres. Taken together, these data implicate parasympathetic function in a novel route through which loneliness may accelerate cellular aging and hasten mortality.
Universidade Paulista, Av. José Maria Whitaker, 290, São Paulo, São Paulo 04057-000, Brazil
http://dx.doi.org/10.1016/j.bbi.2018.11.254
This study analyzed the effects of lipopolysaccharide (LPS)induced sickness behavior on selection between maternal behavior and predatory behavior in lactating rats. We also evaluated general maternal activity and TNF-alpha levels to confirm that LPS-induced sickness behavior. Lactating rats received 100 lg/kg LPS or saline solution on day 5 or 6 of lactation 2 h before the behavioral tests. Five pups and five cockroaches were introduced to the experimental cage at the same time, and maternal, predatory, and general activity behaviors were observed for 30 min. Maternal behavior was measured by the time of pup contact, pup grouping, pup grooming, and nursing. Predatory behavior was measured by the time of insect contact, foraging, and insect eating. General maternal activity was measured by the time of exploration and immobility. Immediately after the observations, blood was collected to measure the plasma TNF-alpha levels. LPS administration reduced the pup contact, pup grouping, and pup grooming, i.e., LPS impaired maternal behavior. LPS increased foraging and the insect eating, i.e., LPS increased predatory behavior. LPS also decreased exploration, increased immobility and TNF-alpha levels, i.e., LPS induced sickness behavior. Thus, LPS-induced sickness behavior during lactation induced predatory behavior instead of maternal behavior in rats. http://dx.doi.org/10.1016/j.bbi.2018.11.253
Abstract # 3133 Loneliness and telomere length: Immune and parasympathetic function in a pathway to accelerated aging S.J. Wilson a,b,c,d,e, A. Woody a, A.C. Padin a,b, J. Lin d, W.B. Malarkey a,d, J.K. Kiecolt-Glaser a,e a
Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, Ohio 43210, United States b Department of Psychology, The Ohio State University, United States c Department of Biochemistry and Biophysics, University of California San Francisco, United States d Department of Internal Medicine, The Ohio State University College of Medicine, United States e Department of Psychiatry and Behavioral Health, The Ohio State University College of Medicine, United States Lonely people’s heightened risks for chronic health conditions and early mortality may emerge in part through cellular aging. Lonelier people have more severe responses to acute stress, increasing their risk for herpesvirus reactivation, a possible path to shorter telomeres. Lower parasympathetic activity may modulate this risk. To examine the associations among loneliness, parasympathetic activity, herpesvirus reactivation, and telomere length, 113 healthy men and women ages 40–85 provided blood samples that were assayed for telomere length, as well as the latent herpesviruses cytomegalovirus (CMV) and Epstein-Barr virus (EBV). They also provided heart rate variability (HRV), a measure of parasympathetic activity, and reported on their feelings of loneliness. Lonelier people with lower HRV (i.e., lower parasympathetic activity) had greater CMV reactivation and shorter telomeres compared to their less lonely counterparts, above and beyond demographics, health behaviors, resting heart rate, and social network size. However, loneliness was not associated with viral reactivation or telomere shortening among those with higher HRV. In turn, greater CMV and EBV
Abstract # 3134 Prenatal LPS increases the switch selection of maternal behavior to predatory behavior in rats independently of sickness behavior T. Mendes-Lima, P.S. Rodrigues, T.B. Kirsten, M.M. Bernardi Universidade Paulista, Av. José Maria Whitaker, 290, São Paulo, São Paulo 04057-000, Brazil Previous study by our group showed that acute lipopolysaccharide (LPS) switches the selection of maternal behavior to predatory behavior in rats. We studied now the effects of a challenged dose of LPS on behavioral selection of F1 lactating rats prenatally exposed to LPS. Female rats prenatally exposed to LPS (on gestation day 9.5) received a LPS challenge on the lactation day 5–6. Maternal behavior, predatory behavior to roaches and maternal general activity were studied. We also evaluated plasmatic TNF-alpha levels. Prenatal LPS (1) did not affect any of the maternal behavior parameters; (2) slightly increased predatory behavior, i.e., it increased foraging; (3) did not affect any of the general activity parameters; (4) did not affect TNF-alpha levels. Prenatal + postnatal LPS (1) impaired maternal behavior, i.e., reduced pup contact, pup grouping, and pup grooming; (2) increased predatory behavior, i.e., it increased insect contact and foraging; (3) impaired general activity, i.e., it decreased exploratory behavior and increased immobility; (4) increased TNFalpha levels. Thus, prenatal + postnatal LPS induced sickness behavior because it decreased general activity and increased TNF-alpha levels. Independently of sickness behavior, prenatal LPS increased the switch selection of maternal behavior to predatory behavior in rats. http://dx.doi.org/10.1016/j.bbi.2018.11.255
Abstract # 3135 Additive and interactive associations of optimism and depressive symptoms with inflammation: Findings from the DETECT study cohort S. Hulsken a,b, S. Aldred b, J.J. Veldhuijzen van Zanten b, R. Herr c, W. März d, B. Schmidt e, L. Pieper f, H. Wittchen f, J.A. Bosch a a Clinical Psychology, University of Amsterdam, Postbus 15933, Amsterdam, 1001NK, Netherlands b School of Sports, Exercise, and Rehabilitation Sciences, University of Birmingham, United Kingdom c Mannheim Institute of Public Health, Heidelberg University, Germany d Centre for Health and Society, Heinrich Heine University, Germany e Department of Business, Work & Organizational Psychology, Applied University Fresenius, Germany f Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Germany
Dispositional optimism and depression have each been independently linked to inflammation. The current study investigated possible independent and interactive (i.e. additive or moderating) associations with inflammation. Analyses explored if such associations varied by health status. Plasma CRP, dispositional optimism, and current depressive symptoms were assessed in 5740 primary care patients, and associations were estimated using linear and
Abstracts / Brain, Behavior, and Immunity 76 (2019) e1–e43
Abstract # 3132 LPS-induced sickness behavior during lactation induces predatory behavior instead of maternal behavior in rats T. Mendes-Lima, P.S. Rodrigues, T.B. Kirsten, M.M. Bernardi
reactivation was associated with shorter telomeres. Taken together, these data implicate parasympathetic function in a novel route through which loneliness may accelerate cellular aging and hasten mortality.
Universidade Paulista, Av. José Maria Whitaker, 290, São Paulo, São Paulo 04057-000, Brazil
http://dx.doi.org/10.1016/j.bbi.2018.11.254
This study analyzed the effects of lipopolysaccharide (LPS)induced sickness behavior on selection between maternal behavior and predatory behavior in lactating rats. We also evaluated general maternal activity and TNF-alpha levels to confirm that LPS-induced sickness behavior. Lactating rats received 100 lg/kg LPS or saline solution on day 5 or 6 of lactation 2 h before the behavioral tests. Five pups and five cockroaches were introduced to the experimental cage at the same time, and maternal, predatory, and general activity behaviors were observed for 30 min. Maternal behavior was measured by the time of pup contact, pup grouping, pup grooming, and nursing. Predatory behavior was measured by the time of insect contact, foraging, and insect eating. General maternal activity was measured by the time of exploration and immobility. Immediately after the observations, blood was collected to measure the plasma TNF-alpha levels. LPS administration reduced the pup contact, pup grouping, and pup grooming, i.e., LPS impaired maternal behavior. LPS increased foraging and the insect eating, i.e., LPS increased predatory behavior. LPS also decreased exploration, increased immobility and TNF-alpha levels, i.e., LPS induced sickness behavior. Thus, LPS-induced sickness behavior during lactation induced predatory behavior instead of maternal behavior in rats. http://dx.doi.org/10.1016/j.bbi.2018.11.253
Abstract # 3133 Loneliness and telomere length: Immune and parasympathetic function in a pathway to accelerated aging S.J. Wilson a,b,c,d,e, A. Woody a, A.C. Padin a,b, J. Lin d, W.B. Malarkey a,d, J.K. Kiecolt-Glaser a,e a
Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, Ohio 43210, United States b Department of Psychology, The Ohio State University, United States c Department of Biochemistry and Biophysics, University of California San Francisco, United States d Department of Internal Medicine, The Ohio State University College of Medicine, United States e Department of Psychiatry and Behavioral Health, The Ohio State University College of Medicine, United States Lonely people’s heightened risks for chronic health conditions and early mortality may emerge in part through cellular aging. Lonelier people have more severe responses to acute stress, increasing their risk for herpesvirus reactivation, a possible path to shorter telomeres. Lower parasympathetic activity may modulate this risk. To examine the associations among loneliness, parasympathetic activity, herpesvirus reactivation, and telomere length, 113 healthy men and women ages 40–85 provided blood samples that were assayed for telomere length, as well as the latent herpesviruses cytomegalovirus (CMV) and Epstein-Barr virus (EBV). They also provided heart rate variability (HRV), a measure of parasympathetic activity, and reported on their feelings of loneliness. Lonelier people with lower HRV (i.e., lower parasympathetic activity) had greater CMV reactivation and shorter telomeres compared to their less lonely counterparts, above and beyond demographics, health behaviors, resting heart rate, and social network size. However, loneliness was not associated with viral reactivation or telomere shortening among those with higher HRV. In turn, greater CMV and EBV
Abstract # 3134 Prenatal LPS increases the switch selection of maternal behavior to predatory behavior in rats independently of sickness behavior T. Mendes-Lima, P.S. Rodrigues, T.B. Kirsten, M.M. Bernardi Universidade Paulista, Av. José Maria Whitaker, 290, São Paulo, São Paulo 04057-000, Brazil Previous study by our group showed that acute lipopolysaccharide (LPS) switches the selection of maternal behavior to predatory behavior in rats. We studied now the effects of a challenged dose of LPS on behavioral selection of F1 lactating rats prenatally exposed to LPS. Female rats prenatally exposed to LPS (on gestation day 9.5) received a LPS challenge on the lactation day 5–6. Maternal behavior, predatory behavior to roaches and maternal general activity were studied. We also evaluated plasmatic TNF-alpha levels. Prenatal LPS (1) did not affect any of the maternal behavior parameters; (2) slightly increased predatory behavior, i.e., it increased foraging; (3) did not affect any of the general activity parameters; (4) did not affect TNF-alpha levels. Prenatal + postnatal LPS (1) impaired maternal behavior, i.e., reduced pup contact, pup grouping, and pup grooming; (2) increased predatory behavior, i.e., it increased insect contact and foraging; (3) impaired general activity, i.e., it decreased exploratory behavior and increased immobility; (4) increased TNFalpha levels. Thus, prenatal + postnatal LPS induced sickness behavior because it decreased general activity and increased TNF-alpha levels. Independently of sickness behavior, prenatal LPS increased the switch selection of maternal behavior to predatory behavior in rats. http://dx.doi.org/10.1016/j.bbi.2018.11.255
Abstract # 3135 Additive and interactive associations of optimism and depressive symptoms with inflammation: Findings from the DETECT study cohort S. Hulsken a,b, S. Aldred b, J.J. Veldhuijzen van Zanten b, R. Herr c, W. März d, B. Schmidt e, L. Pieper f, H. Wittchen f, J.A. Bosch a a Clinical Psychology, University of Amsterdam, Postbus 15933, Amsterdam, 1001NK, Netherlands b School of Sports, Exercise, and Rehabilitation Sciences, University of Birmingham, United Kingdom c Mannheim Institute of Public Health, Heidelberg University, Germany d Centre for Health and Society, Heinrich Heine University, Germany e Department of Business, Work & Organizational Psychology, Applied University Fresenius, Germany f Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Germany
Dispositional optimism and depression have each been independently linked to inflammation. The current study investigated possible independent and interactive (i.e. additive or moderating) associations with inflammation. Analyses explored if such associations varied by health status. Plasma CRP, dispositional optimism, and current depressive symptoms were assessed in 5740 primary care patients, and associations were estimated using linear and