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Abstract: P1208 RELATIONSHIP BETWEEN GLYCATED HEMOGLOBIN, BLOOD PRESSURE AND CAROTID ARTERY ATHEROSCLEROSIS IN NONDIABETIC PATIENTS
Poster - CLINICAL ASPECTS OF CVD - Obesity, Insulin Resistance, and Diabetes Abstract: P1208 Citation: Atherosclerosis Supplement 2009, Vol. 10, Issue 2
RELATIONSHIP BETWEEN GLYCATED HEMOGLOBIN, BLOOD PRESSURE AND CAROTID ARTERY ATHEROSCLEROSIS IN NONDIABETIC PATIENTS W Zhu, Y Li Cardiovascular Department, Huashan Hospital, Shanghai Objective—To analyze the relationship between glycated hemoglobin, blood pressure and carotid artery atherosclerosis (AS) in nondiabetic patients. Methods—As a retrospective cross-sectional study, we included 300 patients without any history of diabetic mellitus, who didn't reach diabetic diagnostic criteria in 2-h oral glucose tolerance test. Patient's demographic data, clinical characteristics, and laboratory outcomes were recorded. Carotid ultrasound is performed with a positive result defined as intima-media thickness (IMT) of common carotid artery 0.9mm, or carotid plaque found. Results: Carotid AS positive rate&HbA1c quartile:
HbA1c(%) Carotid AS positive
HbA1c and carotid AS 5.3 5.4&5.6 26/53(49%) 37/63(59%)
5.7&5.9 30/50(60%)
6.0 39/50(78%)
Significant higher carotid AS rate was seen in SBP130mmHg group compared with SBP<130mmHg group(66.5% vs 48.9%, P=0.002) No correlation were found between HbA1c and SBP (r=-0.082, P=0.235). Devide patients according to SBP and HbA1c level: SBP, HbA1c and carotid AS SBP(mmHg)&HbA1 SBP130&HbA1c SBP130&HbA1c SBP130&HbA1c SBP130&HbA1c c(%) 5.6 >5.6 5.6 >5.6 Carotid AS positive 23/54(43%) 27/46(59%) 40/62(65%) 42/54(78%) In Logistic regression analysis, HbA1c (OR=4.1, P=0.009) was established as an independent predictor of carotid AS, independent of variables including sex, BMI, SBP, DBP, LDL, HDL, hsCRP, and fasting and 2-h glucose.
Conclusion: A slight increase of HbA1c may be independently associated with carotid AS in nondiabetic subjects; and the coexistence of elevated SBP may enhance the above association.
RELATIONSHIP BETWEEN GLYCATED HEMOGLOBIN, BLOOD PRESSURE AND CAROTID ARTERY ATHEROSCLEROSIS IN NONDIABETIC PATIENTS W Zhu, Y Li Cardiovascular Department, Huashan Hospital, Shanghai Objective—To analyze the relationship between glycated hemoglobin, blood pressure and carotid artery atherosclerosis (AS) in nondiabetic patients. Methods—As a retrospective cross-sectional study, we included 300 patients without any history of diabetic mellitus, who didn't reach diabetic diagnostic criteria in 2-h oral glucose tolerance test. Patient's demographic data, clinical characteristics, and laboratory outcomes were recorded. Carotid ultrasound is performed with a positive result defined as intima-media thickness (IMT) of common carotid artery 0.9mm, or carotid plaque found. Results: Carotid AS positive rate&HbA1c quartile:
HbA1c(%) Carotid AS positive
HbA1c and carotid AS 5.3 5.4&5.6 26/53(49%) 37/63(59%)
5.7&5.9 30/50(60%)
6.0 39/50(78%)
Significant higher carotid AS rate was seen in SBP130mmHg group compared with SBP<130mmHg group(66.5% vs 48.9%, P=0.002) No correlation were found between HbA1c and SBP (r=-0.082, P=0.235). Devide patients according to SBP and HbA1c level: SBP, HbA1c and carotid AS SBP(mmHg)&HbA1 SBP130&HbA1c SBP130&HbA1c SBP130&HbA1c SBP130&HbA1c c(%) 5.6 >5.6 5.6 >5.6 Carotid AS positive 23/54(43%) 27/46(59%) 40/62(65%) 42/54(78%) In Logistic regression analysis, HbA1c (OR=4.1, P=0.009) was established as an independent predictor of carotid AS, independent of variables including sex, BMI, SBP, DBP, LDL, HDL, hsCRP, and fasting and 2-h glucose.
Conclusion: A slight increase of HbA1c may be independently associated with carotid AS in nondiabetic subjects; and the coexistence of elevated SBP may enhance the above association.