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Abstract: P1318 LIPID RATIOS AND RISK FOR METABOLIC SYNDROME
Poster - EPIDEMIOLOGY OF CVD - Metabolic Syndrome Abstract: P1318 Citation: Atherosclerosis Supplement 2009, Vol. 10, Issue 2
LIPID RATIOS AND RISK FOR METABOLIC SYNDROME D Vaz1, G Rocha1, I Palma1, F Borges1, J Oliveira2 1
Endocrinology, Centro Hospitalar Do Porto, Oporto; 2Clinical Chemistry, Centro Hospitalar Do Porto, Oporto Objectives Studies have shown that Apo B/A1 ratio and total cholesterol/HDL cholesterol ratio are associated with a higher risk for atherosclerosis and vascular events. According to ATP III, metabolic syndrome is defined by the clustering of three of five criteria that include fasting glucose, waist circumference, triglyceride and HDL cholesterol level, and blood pressure. Studies have shown that clustering of these criteria contributes to a higher risk for atherosclerosis and vascular events. We elaborated a retrospective study to determine if there is a relationship between the mentioned lipid ratios and clustering of metabolic syndrome criteria in a population of type 2 diabetic patients. Methods Fifty one type 2 diabetic patients (22 women,29 men; mean age 61±10 years; mean glycated hemoglobin of 8,6±1,8 % and a mean duration of diabetes of 11,6 ±8,3 years) were selected to this study. In their first appointment in our clinic and for each patient, we determined Apo B/A1 ratio and total cholesterol/HDL cholesterol ratio. We calculated spearman correlation coefficient between lipid ratios and number of metabolic syndrome criteria clustering in each patient. Results Apo B/A1 ratio showed a positive and significant correlation with the number of metabolic syndrome criteria in each patient (r=0,32;p<0,05). Total cholesterol/HDL cholesterol ratio showed a positive and significant correlation with the number of metabolic syndrome criteria in each patient (r=0,30;p<0,05). Conclusions Increasing levels of both lipid ratios are associated with increasing number of metabolic syndrome criteria in our population of type 2 diabetic patients. Funding
No conflict of interest to declare.
LIPID RATIOS AND RISK FOR METABOLIC SYNDROME D Vaz1, G Rocha1, I Palma1, F Borges1, J Oliveira2 1
Endocrinology, Centro Hospitalar Do Porto, Oporto; 2Clinical Chemistry, Centro Hospitalar Do Porto, Oporto Objectives Studies have shown that Apo B/A1 ratio and total cholesterol/HDL cholesterol ratio are associated with a higher risk for atherosclerosis and vascular events. According to ATP III, metabolic syndrome is defined by the clustering of three of five criteria that include fasting glucose, waist circumference, triglyceride and HDL cholesterol level, and blood pressure. Studies have shown that clustering of these criteria contributes to a higher risk for atherosclerosis and vascular events. We elaborated a retrospective study to determine if there is a relationship between the mentioned lipid ratios and clustering of metabolic syndrome criteria in a population of type 2 diabetic patients. Methods Fifty one type 2 diabetic patients (22 women,29 men; mean age 61±10 years; mean glycated hemoglobin of 8,6±1,8 % and a mean duration of diabetes of 11,6 ±8,3 years) were selected to this study. In their first appointment in our clinic and for each patient, we determined Apo B/A1 ratio and total cholesterol/HDL cholesterol ratio. We calculated spearman correlation coefficient between lipid ratios and number of metabolic syndrome criteria clustering in each patient. Results Apo B/A1 ratio showed a positive and significant correlation with the number of metabolic syndrome criteria in each patient (r=0,32;p<0,05). Total cholesterol/HDL cholesterol ratio showed a positive and significant correlation with the number of metabolic syndrome criteria in each patient (r=0,30;p<0,05). Conclusions Increasing levels of both lipid ratios are associated with increasing number of metabolic syndrome criteria in our population of type 2 diabetic patients. Funding
No conflict of interest to declare.