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Abstract: P345 FEELING DISCONTENT PREDICTS CARDIOVASCULAR EVENTS IN 58-YEAR OLD HEALTHY MEN
Poster - EPIDEMIOLOGY OF CVD - Lifestyle and Worldwide CVD Abstract: P345 Citation: Atherosclerosis Supplement 2009, Vol. 10, Issue 2
FEELING DISCONTENT PREDICTS CARDIOVASCULAR EVENTS IN 58-YEAR OLD HEALTHY MEN G Bergstrom, C Schmidt, P Wahrborg, B Fagerberg The Wallenberg Laboratory, the Sahlgrenska Academy, Gothenburg Background: Psychosocial factors are important for cardiovascular disease. We have previously shown that a feeling of discontent independently predicts stroke in treated hypertensive men. Using the same questionnaire, we tested if discontent predicts outcome in healthy male subjects. Methods: The study included 391 healthy, 58-year old men randomly recruited from a general population in the Gothenburg region. Exclusion criteria were cardiovascular disease, other overt disease or ongoing medication. The Minor Symptoms Evaluation Profile (MSEP) was used to estimate person reported outcome related to subjective CNS-related symptoms. Cardiovascular risk factors and carotid artery ultrasound examinations were performed at baseline. Incidence of cardiovascular events (composite of sudden death, fatal and non-fatal myocardial infarction and stroke as well as revascularization procedures) were recorded during a follow-up time of average 9.4 years. Results: Thirty-nine cardiovascular events occurred during follow-up (14 MI and 12 strokes). Cox-regression analysis revealed that high scores on the MSEP scale for content (=feeling discontent) predicted cardiovascular events. The relationship remained significant after adjustment for potential cardiovascular risk factors; weight, waist-hip ratio, diastolic blood pressure and s-triglycerides (relative risk =1.04; 95% CI, 1.01-1.07; P<0.01). The quartiles of MSE-content score did not differ in any of the at baseline estimated cardiovascular risk factors. Conclusion: We now extend our previous observation showing that an independent association exists between reduced well-being in healthy 58-year old men and their risk of cardiovascular events. Funding: Swedish Heart and Lung Foundation, AstraZeneca.
FEELING DISCONTENT PREDICTS CARDIOVASCULAR EVENTS IN 58-YEAR OLD HEALTHY MEN G Bergstrom, C Schmidt, P Wahrborg, B Fagerberg The Wallenberg Laboratory, the Sahlgrenska Academy, Gothenburg Background: Psychosocial factors are important for cardiovascular disease. We have previously shown that a feeling of discontent independently predicts stroke in treated hypertensive men. Using the same questionnaire, we tested if discontent predicts outcome in healthy male subjects. Methods: The study included 391 healthy, 58-year old men randomly recruited from a general population in the Gothenburg region. Exclusion criteria were cardiovascular disease, other overt disease or ongoing medication. The Minor Symptoms Evaluation Profile (MSEP) was used to estimate person reported outcome related to subjective CNS-related symptoms. Cardiovascular risk factors and carotid artery ultrasound examinations were performed at baseline. Incidence of cardiovascular events (composite of sudden death, fatal and non-fatal myocardial infarction and stroke as well as revascularization procedures) were recorded during a follow-up time of average 9.4 years. Results: Thirty-nine cardiovascular events occurred during follow-up (14 MI and 12 strokes). Cox-regression analysis revealed that high scores on the MSEP scale for content (=feeling discontent) predicted cardiovascular events. The relationship remained significant after adjustment for potential cardiovascular risk factors; weight, waist-hip ratio, diastolic blood pressure and s-triglycerides (relative risk =1.04; 95% CI, 1.01-1.07; P<0.01). The quartiles of MSE-content score did not differ in any of the at baseline estimated cardiovascular risk factors. Conclusion: We now extend our previous observation showing that an independent association exists between reduced well-being in healthy 58-year old men and their risk of cardiovascular events. Funding: Swedish Heart and Lung Foundation, AstraZeneca.