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Abstract: P369 INFLUENCE OF CETP TAQ IB POLYMORPHISM ON LIPID PROFILE AND HDL SUBPOPULATIONS DISTRIBUTION IN WOMEN WITH AND WITHOUT DIABETES
Poster - GENETICS - Genetics of HDL Abstract: P369 Citation: Atherosclerosis Supplement 2009, Vol. 10, Issue 2
INFLUENCE OF CETP TAQ IB POLYMORPHISM ON LIPID PROFILE AND HDL SUBPOPULATIONS DISTRIBUTION IN WOMEN WITH AND WITHOUT DIABETES G Russo1, B Asztalos2, K Horvath2, A di Benedetto1, A Giandalia1, E Schaefer2, D Cucinotta1 1
Internal Medicine, University of Messina, Messina; 2Lipid Metabolism Laboratory, JM-USDAHuman Nutrition Reasearch Center on Aging at Tufts University, Boston, MA
The common TaqIB variant in the gene coding for Cholesteryl ester transfer protein (CETP) has been associated with higher HDL-C levels and, in men, with a less atherogenic HDL subpopulations profile. Similar information are lacking in women. The effect of CETP polymorphism on lipid and lipoprotein profile, as well as on ApoAI-containing HDL subclasses distribution, as determined by two-dimensional gel electrophoresis, was examined in a group of women with and without type 2 diabetes. Diabetic women showed a more atherogenic lipid and HDL-supopulations profile, with lower levels of a-1 (P=0.006), a-2 (P=0.005), and pre a1(P=0.02) HDL particles, and higher concentration of the a-3 HDL subspecies (P=0.02) as compared to controls, independently from menopause, triglycerides and HDL-C concentrations. CETP TaqIB genotype distribution was in the Hardy-Weinberg equilibrium and comparable in the two groups, but the effect of CETP polymorphism was limited to diabetic women. In this group, CETP variant showed significant interactions with HOMAIR (P<0.001), BMI (P<0.001), and triglycerides (P<0.00001); significantly higher HDL-C levels and a more protective HDL subpopulations profile was noted in B2 allele carriers with lower HOMAIR, BMI and triglycerides levels. At multivariate analysis, CETP TaqIB (P=0.006) variant was confirmed to be a significant predictor of HDL-C levels in diabetic women only, together with apo AI ( P<0.0001), triglycerides (P<0.0001) and BMI (P=0.023).
INFLUENCE OF CETP TAQ IB POLYMORPHISM ON LIPID PROFILE AND HDL SUBPOPULATIONS DISTRIBUTION IN WOMEN WITH AND WITHOUT DIABETES G Russo1, B Asztalos2, K Horvath2, A di Benedetto1, A Giandalia1, E Schaefer2, D Cucinotta1 1
Internal Medicine, University of Messina, Messina; 2Lipid Metabolism Laboratory, JM-USDAHuman Nutrition Reasearch Center on Aging at Tufts University, Boston, MA
The common TaqIB variant in the gene coding for Cholesteryl ester transfer protein (CETP) has been associated with higher HDL-C levels and, in men, with a less atherogenic HDL subpopulations profile. Similar information are lacking in women. The effect of CETP polymorphism on lipid and lipoprotein profile, as well as on ApoAI-containing HDL subclasses distribution, as determined by two-dimensional gel electrophoresis, was examined in a group of women with and without type 2 diabetes. Diabetic women showed a more atherogenic lipid and HDL-supopulations profile, with lower levels of a-1 (P=0.006), a-2 (P=0.005), and pre a1(P=0.02) HDL particles, and higher concentration of the a-3 HDL subspecies (P=0.02) as compared to controls, independently from menopause, triglycerides and HDL-C concentrations. CETP TaqIB genotype distribution was in the Hardy-Weinberg equilibrium and comparable in the two groups, but the effect of CETP polymorphism was limited to diabetic women. In this group, CETP variant showed significant interactions with HOMAIR (P<0.001), BMI (P<0.001), and triglycerides (P<0.00001); significantly higher HDL-C levels and a more protective HDL subpopulations profile was noted in B2 allele carriers with lower HOMAIR, BMI and triglycerides levels. At multivariate analysis, CETP TaqIB (P=0.006) variant was confirmed to be a significant predictor of HDL-C levels in diabetic women only, together with apo AI ( P<0.0001), triglycerides (P<0.0001) and BMI (P=0.023).