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Abstract: P420 LIPOPROTEINS AND CHOLESTERYL ESTER TRANSFER PROTEIN LEVELS AS RISK FACTORS FOR SEVERE SEPSIS AND MORTALITY IN HOSPITALIZED PATIENTS
Poster - LIPOPROTEIN METABOLISM - Reverse Cholesterol Transport and HDL Metabolism Abstract: P420 Citation: Atherosclerosis Supplement 2009, Vol. 10, Issue 2
LIPOPROTEINS AND CHOLESTERYL ESTER TRANSFER PROTEIN LEVELS AS RISK FACTORS FOR SEVERE SEPSIS AND MORTALITY IN HOSPITALIZED PATIENTS C Grion, L Cardoso, T Perazolo, A Garcia, D Barbosa, H Morimoto, T Matsuo, A Carrilho Londrina State University, Londrina Objectives: Investigate lipoprotein levels as risk factors for sepsis in hospitalized patients by measuring lipoprotein and cholesterol ester transfer protein (CETP) levels during sepsis, and assessing association with mortality. Methods: Case-control study of incident cases in hospitalized patients, followed by a longitudinal prospective study of the same case group. Blood samples were collected at admission from adult patients hospitalized and participants were monitored for severe sepsis. Total cholesterol, HDL, LDL, triglyceride, apolipoproteins, phospholipids and CETP levels were measured and compared between sepsis cases and controls. Thereafter, subsequent measures of cholesterol, apolipoproteins, phospholipids and CETP concentrations were monitored in the case group. Results: Fifty-one patients out of 1,719 enrolled (2.96 %) developed severe sepsis, and were paired with 51 controls by age, sex and chronic disease. HDL cholesterol levels at admission emerged in the final multivariate logistic regression model as a risk factor for severe sepsis (OR=0.971;95% CI=0.945-0.998). Mean CETP levels diminished between hospital admission and the third day of sepsis, and the magnitude of this variation ([Delta]CETP) was more pronounced in non-survivors (0.78±1.08 μg/mL) than survivors (0.02±0.58 μg/mL, p=0.01). Conclusions: HDL cholesterol has a protective effect against sepsis. Each 1 mg/dL increase in HDL decreased odds of severe sepsis by 3% during hospitalization, and the reduction of plasma CETP was associated with mortality. Funding: The Post-graduate Program in Medicine and The University Hospital Technology Support Foundation (HUTEC).
LIPOPROTEINS AND CHOLESTERYL ESTER TRANSFER PROTEIN LEVELS AS RISK FACTORS FOR SEVERE SEPSIS AND MORTALITY IN HOSPITALIZED PATIENTS C Grion, L Cardoso, T Perazolo, A Garcia, D Barbosa, H Morimoto, T Matsuo, A Carrilho Londrina State University, Londrina Objectives: Investigate lipoprotein levels as risk factors for sepsis in hospitalized patients by measuring lipoprotein and cholesterol ester transfer protein (CETP) levels during sepsis, and assessing association with mortality. Methods: Case-control study of incident cases in hospitalized patients, followed by a longitudinal prospective study of the same case group. Blood samples were collected at admission from adult patients hospitalized and participants were monitored for severe sepsis. Total cholesterol, HDL, LDL, triglyceride, apolipoproteins, phospholipids and CETP levels were measured and compared between sepsis cases and controls. Thereafter, subsequent measures of cholesterol, apolipoproteins, phospholipids and CETP concentrations were monitored in the case group. Results: Fifty-one patients out of 1,719 enrolled (2.96 %) developed severe sepsis, and were paired with 51 controls by age, sex and chronic disease. HDL cholesterol levels at admission emerged in the final multivariate logistic regression model as a risk factor for severe sepsis (OR=0.971;95% CI=0.945-0.998). Mean CETP levels diminished between hospital admission and the third day of sepsis, and the magnitude of this variation ([Delta]CETP) was more pronounced in non-survivors (0.78±1.08 μg/mL) than survivors (0.02±0.58 μg/mL, p=0.01). Conclusions: HDL cholesterol has a protective effect against sepsis. Each 1 mg/dL increase in HDL decreased odds of severe sepsis by 3% during hospitalization, and the reduction of plasma CETP was associated with mortality. Funding: The Post-graduate Program in Medicine and The University Hospital Technology Support Foundation (HUTEC).