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Acetaldehyde ethyl linalyl acetal
Fragrance raw materials monographs
281
ACETALDEHYDE ETHYL LINALYL ACETAL
Synonyms: Elintaal; 1-ethoxy- l-linalyloxethane; ethyl linalyl acetal. CAS Registry No. 40910-49-4 CAS Index Name: 1,6-octadiene, 3-(l-ethoxyethoxy)-3,7-dimethylStructure: (CH 3)2C : CH •CH2-CH2(CH 3)C(CH :CH 2) •OCH(OCH2CH 3).CH 3 Description: A clear liquid. Occurrence: Has apparently not been reported to occur in nature. Preparation: By addition of linalool to ethyl vinyl ether. Physical properties: Refractive index Specific gravity
1.447-1.449 0.872-0.878
(Analytical data on the material as tested by RIFM.) Gas chromatogram and infra-red curve on file at RIFM.
Biological data Acute toxicity. The acute oral LDs0 in rats exceeded 5 g/kg based on 0/10 deaths at that dose, and the acute dermal LDs0 in rabbits exceeded 5 g/kg based on 0/5 deaths (Moreno, 1980). Irritation. As part of an acute dermal LDs0 study, the undiluted material produced irritant effects with scaly and crusted skin at necropsy in rabbits patch-tested for 24 hr under occlusion at a dose of 5 g/kg (Moreno, 1980). A 48-hr closed-patch test at a concentration of 6% in petrolatum on the backs of 26 volunteers produced no irritation (Epstein, 1980). Sensitization. A maximization test (Kligman, 1966; Kligman & Epstein, 1975) was carried out on 26 volunteers. The material was tested at a concentration of 6 o in petrolatum and produced no sensitization reactions (Epstein, 1980). This test concentration was based on a reported maximum concentration of 0.6% in consumer products.
References Epstein, W. L. (1980). Report to RIFM, 7 July. Kligman, A. M. (1966). The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers. J. invest. Derm. 47, 393. Kligman, A. M. & Epstein, W. (1975). Updating the maximization test for identifying contact allergens. Contact Dermatitis 1, 231. Moreno, O. M. (1980). Report to RIFM, 30 August.
281
ACETALDEHYDE ETHYL LINALYL ACETAL
Synonyms: Elintaal; 1-ethoxy- l-linalyloxethane; ethyl linalyl acetal. CAS Registry No. 40910-49-4 CAS Index Name: 1,6-octadiene, 3-(l-ethoxyethoxy)-3,7-dimethylStructure: (CH 3)2C : CH •CH2-CH2(CH 3)C(CH :CH 2) •OCH(OCH2CH 3).CH 3 Description: A clear liquid. Occurrence: Has apparently not been reported to occur in nature. Preparation: By addition of linalool to ethyl vinyl ether. Physical properties: Refractive index Specific gravity
1.447-1.449 0.872-0.878
(Analytical data on the material as tested by RIFM.) Gas chromatogram and infra-red curve on file at RIFM.
Biological data Acute toxicity. The acute oral LDs0 in rats exceeded 5 g/kg based on 0/10 deaths at that dose, and the acute dermal LDs0 in rabbits exceeded 5 g/kg based on 0/5 deaths (Moreno, 1980). Irritation. As part of an acute dermal LDs0 study, the undiluted material produced irritant effects with scaly and crusted skin at necropsy in rabbits patch-tested for 24 hr under occlusion at a dose of 5 g/kg (Moreno, 1980). A 48-hr closed-patch test at a concentration of 6% in petrolatum on the backs of 26 volunteers produced no irritation (Epstein, 1980). Sensitization. A maximization test (Kligman, 1966; Kligman & Epstein, 1975) was carried out on 26 volunteers. The material was tested at a concentration of 6 o in petrolatum and produced no sensitization reactions (Epstein, 1980). This test concentration was based on a reported maximum concentration of 0.6% in consumer products.
References Epstein, W. L. (1980). Report to RIFM, 7 July. Kligman, A. M. (1966). The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers. J. invest. Derm. 47, 393. Kligman, A. M. & Epstein, W. (1975). Updating the maximization test for identifying contact allergens. Contact Dermatitis 1, 231. Moreno, O. M. (1980). Report to RIFM, 30 August.