Acetyl cedrene

639

Fragrance raw materials monographs ACETYL Syonwl:

Vertolix

Descriprion

and

Occurrence: Prepcrrution:

CEDRENE

coeur.

p/r~ka/

A white syrupy material. not been reported to occur in nature. of the hydrocarbon portion of cedarwood

properries:

Has apparently By acetylation

oil in the presence of an acid catalyst. Loses: In public use since the 1950s. Use in fragrances in the USA amounts to approximately ~200,000 Ib/yr. Concentration in final product (O/in): Soap

Usual Maximum Andyrid

darn:

Deteryrnr

O-05 0.5

Gas chromatogram.

Creams,

RIFM

lorions

0.025 0.2

OGOS 0.05

no. 71-89: infra-red curve. RIFM

Perfume

0.8 3.0 no. 71-89.

Status Acetyl cedrene is not included in the listings of the FDA, FEMA (I 974). or in the Fond Chemicufs Codex (1972). Biological

(1965) or the Council

of Europe

data

Acute roxicir!.. The acute oral LDSo in rats was reported as 5.2 ml/kg (44--6.0ml,/kg) and the acute dermal LDse in rabbits exceeded Zg/kg (Moreno, 1972). Irritation. Acetyl cedrene applied full strength to intact or abraded rabbit skin for 24 hr under occlusion was moderately irritating (Moreno, 1972). Tested at 30% in petrolatum, it produced no - irritation after a 48-hr closed-patch test on human subjects (Kligman, 1972). Sertsiri:crriori. A maximization test (Kligman. 1966: Kligman & Epstein, 1975) was carried out on 25 volunteers. The material (RIFM no. 71-89). tested at a concentration of 30% in petrolatum, produced no sensitization reactions (Kligman, 1972).

References Council of Europe (1974). Natural Flavouring Substances. Their Sources. and Added Artificial Flavouring Substances. Partial Agreement in the Social and Public Health Field. Strasbourg. Flavoring Extract Manufacturers’ Association (1965). Survey of flavoring ingredient usage levels. Ftl Techno/.. Chumpaiyn 19(2). part 2. 155. Food Chrmictrls C&x (1972). 2nd Ed. Prepared by the Committee on Specifications. Food Chemicals Codex. of the Committee on Food Protection. National Academy of Sciences-National Research Council Publ. 1406. Washington. DC. Kligman. A. M. (1966). The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers. J. inresr. Derni. 47, 393. Kligman. A. M. (1972). Report to RIFM. 2 May. Kligman. A. M. & Epstein. W. (1975). Updating the maximization test for identifying contact allergens. Conrtrcr Derrnariris I, 231. Moreno. 0. M. (1972). Reports to RIFM. I3 February and I4 March.