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ACUTE ADMINISTRATION OF VARDENAFIL IMPROVES ARTERIAL STIFFNESS AND WAVE REFLECTIONS
A50.E472 JACC March 9, 2010 Volume 55, issue 10A
HYPERTENSION, LIPIDS AND PREVENTION ACUTE ADMINISTRATION OF VARDENAFIL IMPROVES ARTERIAL STIFFNESS AND WAVE REFLECTIONS ACC Poster Contributions Georgia World Congress Center, Hall B5 Sunday, March 14, 2010, 9:30 a.m.-10:30 a.m.
Session Title: Novel Effects of Common Cardiac Medication Abstract Category: Pharmacology/Hormones/Lipids—Clinical Presentation Number: 1021-109 Authors: Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Konstantinos Aznaouridis, Konstantinos Rokkas, Athanasios Aggelis, Katerina Baou, Athanasios Askitis, Christodoulos Stefanadis, 1st Department of Cardiology, Hippokration Hospital, Athens Medical School, Athens, Greece Background: While vardenafil is widely prescribed for erectile dysfunction, its effect on arterial function is not established. Arterial stiffness, aortic pressures and wave reflections are markers of cardiovascular disease and predictors of cardiovascular risk. We assessed the hypothesis that vardenafil acutely improves arterial stiffness, aortic pressures and wave reflections in patients with erectile dysfunction. Methods: Ten patients (mean age 58±10 years) with erectile dysfunction received vardenafil 20 mg in a randomized, placebo-controlled, double-blind, 2-way cross-over design. Arterial elastic properties were evaluated with carotid-femoral pulse wave velocity (cfPWV); wave reflections and aortic pressures were evaluated with augmentation index (AIx) and systolic, diastolic and pulse pressure of the aortic pressure waveform, respectively. cfPWV, central pressures and AIx were measured at baseline and every 30 min for 3 hours after the vardenafil intake or placebo. Results: cfPWV decreased significantly (by 0.502 m/s, p<0.01), denoting a decrease in arterial stiffness (Figure). AIx decreased significantly (by 3.11%, p<0.01), denoting a decreased effect of wave reflections from the periphery (Figure). Aortic pulse pressure decreased significantly (by 5.09 mmHg, p<0.01). Moreover, aortic systolic and diastolic pressure decreased significantly (by 12.38 mmHg, peak effect at 60 min, p<0.005 and by 7.68 mmHg, peak effect at 90 min, p<0.005, respectively). Furthermore, brachial systolic, diastolic and pulse pressure decreased significantly (p<0.05). There was no significant change in heart rate (p>0.05). The effect of vardenafil lasted throughout the study (3 hours), being evident 30 to 60 min after drug intake. Conclusions: Vardenafil has a beneficial effect on arterial function in patients with erectile dysfunction. The effect is explicable on the basis of vascular phosphodiesterase type 5 inhibition. This finding expands our understanding of the overall cardiovascular profile of vardenafil.
HYPERTENSION, LIPIDS AND PREVENTION ACUTE ADMINISTRATION OF VARDENAFIL IMPROVES ARTERIAL STIFFNESS AND WAVE REFLECTIONS ACC Poster Contributions Georgia World Congress Center, Hall B5 Sunday, March 14, 2010, 9:30 a.m.-10:30 a.m.
Session Title: Novel Effects of Common Cardiac Medication Abstract Category: Pharmacology/Hormones/Lipids—Clinical Presentation Number: 1021-109 Authors: Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Konstantinos Aznaouridis, Konstantinos Rokkas, Athanasios Aggelis, Katerina Baou, Athanasios Askitis, Christodoulos Stefanadis, 1st Department of Cardiology, Hippokration Hospital, Athens Medical School, Athens, Greece Background: While vardenafil is widely prescribed for erectile dysfunction, its effect on arterial function is not established. Arterial stiffness, aortic pressures and wave reflections are markers of cardiovascular disease and predictors of cardiovascular risk. We assessed the hypothesis that vardenafil acutely improves arterial stiffness, aortic pressures and wave reflections in patients with erectile dysfunction. Methods: Ten patients (mean age 58±10 years) with erectile dysfunction received vardenafil 20 mg in a randomized, placebo-controlled, double-blind, 2-way cross-over design. Arterial elastic properties were evaluated with carotid-femoral pulse wave velocity (cfPWV); wave reflections and aortic pressures were evaluated with augmentation index (AIx) and systolic, diastolic and pulse pressure of the aortic pressure waveform, respectively. cfPWV, central pressures and AIx were measured at baseline and every 30 min for 3 hours after the vardenafil intake or placebo. Results: cfPWV decreased significantly (by 0.502 m/s, p<0.01), denoting a decrease in arterial stiffness (Figure). AIx decreased significantly (by 3.11%, p<0.01), denoting a decreased effect of wave reflections from the periphery (Figure). Aortic pulse pressure decreased significantly (by 5.09 mmHg, p<0.01). Moreover, aortic systolic and diastolic pressure decreased significantly (by 12.38 mmHg, peak effect at 60 min, p<0.005 and by 7.68 mmHg, peak effect at 90 min, p<0.005, respectively). Furthermore, brachial systolic, diastolic and pulse pressure decreased significantly (p<0.05). There was no significant change in heart rate (p>0.05). The effect of vardenafil lasted throughout the study (3 hours), being evident 30 to 60 min after drug intake. Conclusions: Vardenafil has a beneficial effect on arterial function in patients with erectile dysfunction. The effect is explicable on the basis of vascular phosphodiesterase type 5 inhibition. This finding expands our understanding of the overall cardiovascular profile of vardenafil.