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Adenomatoid odontogenic tumor: cystic lesion with large extension
OOOO Volume 114, Number 4
ORAL ABSTRACT Abstracts e53
ACCURACY OF THE MICRONUCLEUS TEST IN THE DIAGNOSIS OF MALIGNANT LESIONS OF THE ORAL CAVITY Medella JR FAC1, Vargas RJA2, Munerato MC1, Bozzetti MC2 - 1UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - ESTOMATOLOGIA - HCPA, 2UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - HOSPITAL DE CLINICAS DE PORTO ALEGRE - RS
revealed neonatal jaundice that persisted until liver transplantation at eight-year-old and mental retardation. The differential diagnosis of green teeth includes extrinsic and intrinsic discoloration. The final diagnosis of bilirubin pigmentation is usually based on a clinical history of jaundice combined with green teeth discoloration and less often enamel hypoplasia.
Background/aim: The use of biomarkers of chromosomal damage (CD) to screen high-risk individuals for oral cancer is imperative. Oral cancer is a serious global healthcare problem due to its rising incidence and common late-stage presentation. This study aimed at assessing the sensitivity and specificity of (MN) frequency - in exfoliated buccal mucosa cells - for detecting malignant or potentially malignant oral cavity lesions, having biopsy (histopathologic) as the reference standard. Study design: The micronucleus (MN) test is used as an indicator of CD and an increased MN’s frequency is related to the development of oral cancer. The present study aimed at assessing the sensitivity and specificity of micronucleus test frequency for detecting malignant or potentially malignant oral cavity lesions. We carried out a cross-sectional study with 48 participants presenting oral cavity lesion, who were indicated to undergo surgery biopsy. Eleven patients (22.9%) presented malignant or potentially malignant oral cavity lesions. The MN’s frequencies higher than 0.0005 had a sensitivity of 63.6% and a specificity of 43.2% in samples of perilesional area. The predictive positive (PPV) and negative (PNV) values were 25% and 80% respectively. Results: A total of 146 patients were submitted to biopsy of oral cavity lesion in the Stomatology Clinic from HCPA between February and December of 2010. The majority of the 146 patients submitted to biopsy had a previous diagnosis of oral cancer and had followed a treatment. Only 50 out of 146 patients met the inclusion criteria. All patients were submitted to biopsy as we aimed at verifying the sensitivity and specificity of the micronucleus test for detection of malign or potentially malign oral cavity lesions. Conclusion: These results may be due to some study’s limitations. Despite of them, we believe that the methodological issues raised in our study indicate some relevant directions for future research.
ADENOMATOID ODONTOGENIC TUMOR: CYSTIC LESION WITH LARGE EXTENSION Lima GMG1, Colombo CE2, Machado ACP2, Guimarães Filho R2, Americo MG1, Anbinder AL1, Carvalho YR1 - 1UNESP/SÃO JOSÉ DOS CAMPOS - BIOCIÊNCIAS E DIAGNÓSTICO BUCAL, 2 UNIVERSIDADE DE TAUBATÉ - UNITAU
GREEN TEETH ASSOCIATED WITH PROLONGED HYPERBILIRUBINEMIA: CASE REPORT Campos EJ1, Silva LR2, Conceição JS2, Costa LA3, Azevedo FC3, Marchionni AM3, Martins GB1 - 1UNIVERSIDADE FEDERAL DA BAHIA - INSTITUTO DE CIÊNCIAS DA SAÚDE, 2UNIVERSIDADE FEDERAL DA BAHIA - CENTRO DE ESTUDOS EM GASTROENTEROLOGIA E HEPATOLOGIA PEDIÁTRICAS, 3 ESCOLA BAHIANA DE MEDICINA E SAÚDE PÚBLICA CURSO DE ODONTOLOGIA The presence of hyperbilirubinemia during enamel and dentin formation results in dental pigmentation, due to accumulation of intrinsic staining by bilirubin. The extent and intensity of discoloration are directly related to the duration and severity of the pathology. Considering that green staining of dental hard tissues is such uncommon condition, this case report presents an unusual case of a patient underwent liver transplantation and had green pigmentation of all deciduous and permanent teeth associated with hyperbilirubinemia caused by biliary atresia. An fifteen-year-old girl was referred to Dental School for treatment from Pediatric Gastroenterology Service. The medical history
Adenomatoid odontogenic tumor (AOT) is composed of odontogenic epithelium in variable patterns embedded in mature connective tissue. It affects preferentially young females, in anterior maxilla. Case report: a 16 year-old black male, with a painless nodule under the left nostril. Clinical examination revealed a bony-hard 5 cm swelling in left maxilla recovered by intact mucosa. Radiographically, there was a well-defined unilocular radiolucency around an unerupted permanent tooth, with radiopaque foci. Excisional biopsy was carried out with the diagnostic hypotheses of TOA. Histologically it was seen a cystic cavity lined by cuboidal epithelia with localized thickenings and projections to the lumen. In these areas epithelial cells were arranged in nests, strands and rosettes in a vascularized stroma. Within the cellular masses there were duct-like structures lined by a single row of cuboidal or columnar cells. The final diagnosis was Adenomatoid Odontogenic Tumor. Tumor was removed and the patient is being followed.
ORAL EXPRESSION OF DIFFUSE LARGE CELL LYMPHOMA IN PATIENTS WITH HIV Alpaca GHG1, Menezes J2, Arce JPA3 - 1PREFEITURA MUNICIPAL DO RIO DE JANEIRO, 2MINISTÉRIO DA SAÚDE- - HOSPITAL FEDERAL DOS SERVIDORES DO ESTADO, 3MINISTÉRIO DA SAÚDE - HOSPITAL DOS SERVIDORES DO ESTADO Summary: The lymphoma diffuse large B-cell (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL). In individuals infected with human immunodeficiency virus (HIV), the incidence of non-Hodgkin’s lymphoma is 100-200 times than in the general population. The non-Hodgkin’s lymphoma is an AIDS-defining illness. In 3-5% of cases is the initial manifestation. Although these lymphomas are often of B cells in these patients, the reports about the oral manifestations are few .The Objective this work is reporting a case of non-Hodgkin B cell lymphoma of the oral cavity in patients with acquired immunodeficiency syndrome Case report: Patient RAS, 25, female, came to dental care by presenting nodular, granulomatous, in the anterior maxilla affecting the upper incisors, without other systemic manifestations. The lesion was resected. Histological diagnosis and immunohistochemical study confirmed the secondary form of lymphoma, because the serological investigation revealed positive serology for HIV. At the time the CD4 cell count was 52mm3 and viral load of 2853. Being started chemotherapy associated with HAART. Five months after therapy, the patient was in remission from lymphoma, with a significant reduction in viral load. The CD4 count was 247 cells/mm3 and viral load of 59mm3. Final Thoughts This case reveals that the early recognition and diag-
ORAL ABSTRACT Abstracts e53
ACCURACY OF THE MICRONUCLEUS TEST IN THE DIAGNOSIS OF MALIGNANT LESIONS OF THE ORAL CAVITY Medella JR FAC1, Vargas RJA2, Munerato MC1, Bozzetti MC2 - 1UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - ESTOMATOLOGIA - HCPA, 2UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - HOSPITAL DE CLINICAS DE PORTO ALEGRE - RS
revealed neonatal jaundice that persisted until liver transplantation at eight-year-old and mental retardation. The differential diagnosis of green teeth includes extrinsic and intrinsic discoloration. The final diagnosis of bilirubin pigmentation is usually based on a clinical history of jaundice combined with green teeth discoloration and less often enamel hypoplasia.
Background/aim: The use of biomarkers of chromosomal damage (CD) to screen high-risk individuals for oral cancer is imperative. Oral cancer is a serious global healthcare problem due to its rising incidence and common late-stage presentation. This study aimed at assessing the sensitivity and specificity of (MN) frequency - in exfoliated buccal mucosa cells - for detecting malignant or potentially malignant oral cavity lesions, having biopsy (histopathologic) as the reference standard. Study design: The micronucleus (MN) test is used as an indicator of CD and an increased MN’s frequency is related to the development of oral cancer. The present study aimed at assessing the sensitivity and specificity of micronucleus test frequency for detecting malignant or potentially malignant oral cavity lesions. We carried out a cross-sectional study with 48 participants presenting oral cavity lesion, who were indicated to undergo surgery biopsy. Eleven patients (22.9%) presented malignant or potentially malignant oral cavity lesions. The MN’s frequencies higher than 0.0005 had a sensitivity of 63.6% and a specificity of 43.2% in samples of perilesional area. The predictive positive (PPV) and negative (PNV) values were 25% and 80% respectively. Results: A total of 146 patients were submitted to biopsy of oral cavity lesion in the Stomatology Clinic from HCPA between February and December of 2010. The majority of the 146 patients submitted to biopsy had a previous diagnosis of oral cancer and had followed a treatment. Only 50 out of 146 patients met the inclusion criteria. All patients were submitted to biopsy as we aimed at verifying the sensitivity and specificity of the micronucleus test for detection of malign or potentially malign oral cavity lesions. Conclusion: These results may be due to some study’s limitations. Despite of them, we believe that the methodological issues raised in our study indicate some relevant directions for future research.
ADENOMATOID ODONTOGENIC TUMOR: CYSTIC LESION WITH LARGE EXTENSION Lima GMG1, Colombo CE2, Machado ACP2, Guimarães Filho R2, Americo MG1, Anbinder AL1, Carvalho YR1 - 1UNESP/SÃO JOSÉ DOS CAMPOS - BIOCIÊNCIAS E DIAGNÓSTICO BUCAL, 2 UNIVERSIDADE DE TAUBATÉ - UNITAU
GREEN TEETH ASSOCIATED WITH PROLONGED HYPERBILIRUBINEMIA: CASE REPORT Campos EJ1, Silva LR2, Conceição JS2, Costa LA3, Azevedo FC3, Marchionni AM3, Martins GB1 - 1UNIVERSIDADE FEDERAL DA BAHIA - INSTITUTO DE CIÊNCIAS DA SAÚDE, 2UNIVERSIDADE FEDERAL DA BAHIA - CENTRO DE ESTUDOS EM GASTROENTEROLOGIA E HEPATOLOGIA PEDIÁTRICAS, 3 ESCOLA BAHIANA DE MEDICINA E SAÚDE PÚBLICA CURSO DE ODONTOLOGIA The presence of hyperbilirubinemia during enamel and dentin formation results in dental pigmentation, due to accumulation of intrinsic staining by bilirubin. The extent and intensity of discoloration are directly related to the duration and severity of the pathology. Considering that green staining of dental hard tissues is such uncommon condition, this case report presents an unusual case of a patient underwent liver transplantation and had green pigmentation of all deciduous and permanent teeth associated with hyperbilirubinemia caused by biliary atresia. An fifteen-year-old girl was referred to Dental School for treatment from Pediatric Gastroenterology Service. The medical history
Adenomatoid odontogenic tumor (AOT) is composed of odontogenic epithelium in variable patterns embedded in mature connective tissue. It affects preferentially young females, in anterior maxilla. Case report: a 16 year-old black male, with a painless nodule under the left nostril. Clinical examination revealed a bony-hard 5 cm swelling in left maxilla recovered by intact mucosa. Radiographically, there was a well-defined unilocular radiolucency around an unerupted permanent tooth, with radiopaque foci. Excisional biopsy was carried out with the diagnostic hypotheses of TOA. Histologically it was seen a cystic cavity lined by cuboidal epithelia with localized thickenings and projections to the lumen. In these areas epithelial cells were arranged in nests, strands and rosettes in a vascularized stroma. Within the cellular masses there were duct-like structures lined by a single row of cuboidal or columnar cells. The final diagnosis was Adenomatoid Odontogenic Tumor. Tumor was removed and the patient is being followed.
ORAL EXPRESSION OF DIFFUSE LARGE CELL LYMPHOMA IN PATIENTS WITH HIV Alpaca GHG1, Menezes J2, Arce JPA3 - 1PREFEITURA MUNICIPAL DO RIO DE JANEIRO, 2MINISTÉRIO DA SAÚDE- - HOSPITAL FEDERAL DOS SERVIDORES DO ESTADO, 3MINISTÉRIO DA SAÚDE - HOSPITAL DOS SERVIDORES DO ESTADO Summary: The lymphoma diffuse large B-cell (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL). In individuals infected with human immunodeficiency virus (HIV), the incidence of non-Hodgkin’s lymphoma is 100-200 times than in the general population. The non-Hodgkin’s lymphoma is an AIDS-defining illness. In 3-5% of cases is the initial manifestation. Although these lymphomas are often of B cells in these patients, the reports about the oral manifestations are few .The Objective this work is reporting a case of non-Hodgkin B cell lymphoma of the oral cavity in patients with acquired immunodeficiency syndrome Case report: Patient RAS, 25, female, came to dental care by presenting nodular, granulomatous, in the anterior maxilla affecting the upper incisors, without other systemic manifestations. The lesion was resected. Histological diagnosis and immunohistochemical study confirmed the secondary form of lymphoma, because the serological investigation revealed positive serology for HIV. At the time the CD4 cell count was 52mm3 and viral load of 2853. Being started chemotherapy associated with HAART. Five months after therapy, the patient was in remission from lymphoma, with a significant reduction in viral load. The CD4 count was 247 cells/mm3 and viral load of 59mm3. Final Thoughts This case reveals that the early recognition and diag-