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Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes
Accepted Manuscript Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes Mark P. Jedrychowski, Libin Liu, Collette J. Laflamme, Kalypso Karastergiou, Tova Meshulam, Shi-Ying Ding, Yuanyuan Wu, Mi-Jeong Lee, Steven P. Gygi, Susan K. Fried, Paul F. Pilch PII:
S2212-8778(15)00172-6
DOI:
10.1016/j.molmet.2015.09.002
Reference:
MOLMET 267
To appear in:
Molecular Metabolism
Received Date: 19 August 2015 Revised Date:
28 August 2015
Accepted Date: 3 September 2015
Please cite this article as: Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding S-Y, Wu Y, Lee M-J, Gygi SP, Fried SK, Pilch PF, Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes, Molecular Metabolism (2015), doi: 10.1016/ j.molmet.2015.09.002. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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Adiporedoxin, an upstream regulator of ER oxidative folding and protein
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secretion in adipocytes
Mark P. Jedrychowski1,3, Libin Liu1, Collette J. Laflamme1, Kalypso Karastergiou2,
Tova Meshulam1, Shi-Ying Ding1, Yuanyuan Wu2, Mi-Jeong Lee2, Steven P. Gygi3,
Departments of Biochemistry, Boston University School of Medicine, 715 Albany Street,
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Susan K. Fried2 and Paul F. Pilch1, 2*
Boston, MA 02118. USA. 2
Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston,
MA 02118. USA.
Department of Cell Biology, Harvard University School of Medicine. 240 Longwood Avenue
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Boston, MA 02115, USA.
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*Corresponding author: Paul F. Pilch, Department of Biochemistry, Boston University School of Medicine, 72 E. Concord St., Boston, MA 02118. Phone 617-638-4044, email: [email protected] 1
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Abstract Objective
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Adipocytes are robust protein secretors, most notably of adipokines, hormone-like polypeptides, which act in an endocrine and paracrine fashion to affect numerous physiological processes such as energy balance and insulin sensitivity. To understand how such proteins are assembled for
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secretion we describe the function of a novel endoplasmic reticulum oxidoreductase, adiporedoxin (Adrx).
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Methods
Adrx knockdown and overexpressing 3T3-L1 murine adipocyte cell lines and a knockout mouse model were used to assess the influence of Adrx on secreted proteins as well as the redox state of ER resident chaperones. The metabolic phenotypes of Adrx null mice were characterized and
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compared to WT mice. The correlation of Adrx level and BMI, adiponectin levels, and other inflammatory markers from adipose tissue of human subjects were also studied.
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Results
Adiporedoxin functions via a CXXC active site, and is upstream of protein disulfide isomerase
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whose direct function is disulfide bond formation, and ultimately protein secretion. Over and under expression of Adrx in vitro enhances and reduces, respectively, the secretion of the disulfide-bonded proteins including adiponectin and collagen isoforms. On a chow diet, Adrx null mice have normal body weights, and glucose tolerance, are moderately hyperinsulinemic, have reduced levels of circulating adiponectin and are virtually free of adipocyte fibrosis resulting in a complex phenotype tending towards insulin resistance. Adrx protein levels in
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human adipose tissue correlate positively with adiponectin levels and negatively with the inflammatory marker phospho-Jun kinase.
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Conclusion These data support the notion that Adrx plays a critical role in adipocyte biology and in the regulation of mouse and human metabolism via its modulation of adipocyte protein secretion.
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Keywords
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Adipocyte, adipokine, protein secretion, endoplasmic reticulum, oxidoreductase, disulfide
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bond formation.
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1. INTRODUCTION: In addition to fat storage and release, white adipose tissue (WAT) makes and secretes adipokines, hormone-like polypeptides, which act in an endocrine and paracrine fashion to affect
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numerous physiological processes such as energy balance and insulin sensitivity [1, 2]. In addition, fat cells in adipose tissue are maintained as an organ by extracellular matrix proteins including multiple collagen isoforms whose cellular origin is not completely clear [3]. The initial
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folding and assembly of all secreted and integral membrane proteins, takes place in the endoplasmic reticulum (ER) and is mediated by the actions of numerous enzymes and
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chaperones [4-6]. About 1/3 of all cellular proteins pass through the ER and the vast majority of these have inter- and/or intra-molecular disulfide bonds, the formation of which also takes place in the ER mediated by oxidoreductases of the thioredoxin superfamily [6-8]. Improper disulfide bond formation leads to protein misfolding and, potentially, ER stress, which can have
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deleterious consequences for cells, for example, apoptosis in the endocrine pancreas due to insulin misfolding [9, 10]. Therefore, while normal ER function is essential in all cells, it is especially important in secretory cells such as adipocytes and pancreatic beta cells.
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Adiponectin assembly and disulfide bond formation impose a particular burden on the
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adipocyte ER because it circulates at high concentrations, ca. 30 nM, yet is turned over quite rapidly in blood [11]. Adiponectin has a complicated tertiary structure with post-translational modifications that include the ER-dependent formation of intermolecular disulfide bonds that are required for oligomerization into its most physiologically relevant form, an octadecamer (the high molecular weight or HMW form) [12-14], as well as hydroxylation, glycosylation and proline isomerization all of which occur in its collagenous domain [15-17]. Adiponectin must therefore be properly and efficiently assembled and secreted at high rates, and malfunctions of
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this process will lead to ER stress in the adipocyte and subsequent perturbation of fat cell and organismal metabolism such as insulin resistance and type 2 diabetes [18]. The assembly and secretion of collagens from adipocytes (and other cells) also requires disulfide bonds [17], and
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excess collagen deposition leads to a fibrotic pathology in adipose tissue [19].
What little is known about disulfide bond formation in the adipocyte ER, bond formation
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involves adiponectin assembly, which requires the action of the enzyme endoplasmic reticulum oxidoreductase 1α (ERo1α), a primary electron acceptor that uses molecular oxygen and a flavin
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nucleotide to initiate oxidative protein folding [20]. ERo1α does not interact directly with substrates such as adipokines to mediate S-S bond formation, rather it oxidizes members of the protein disulfide isomerase (PDI) family, which interact with substrates and mediate correct disulfide bond formation and protein folding [20-22]. ERo1α has also been shown to interact
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with endoplasmic reticulum protein, ERp44, to mediate what has been called dynamic ER retention of substrates [23]. The combined actions of ERo1α and ERp44 have been shown to play a role in adiponectin assembly and secretion [24, 25]. A third PDI relative implicated in
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adiponectin multimerization is the disulfide bond A oxidoreductase-like protein (DsbA-L) [26]. Unlike ERo1α and ERp44, it lacks both active site cysteines required for redox function and a
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classical ER localization signal, but it may instead have a chaperone function in protein folding. None of the above proteins has a notable tissue-specific distribution although the expression of DsbA-L is somewhat higher in adipose than in other tissues examined, and it is induced upon differentiation of 3T3-L1 cells [26]. We performed a proteomic analysis of GLUT4 storage vesicles (GSVs) that were selectively immunoadsorbed with anti-GLUT4-coupled beads following depletion of GLUT4-
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precursor compartments [27]. Amongst the proteins we discovered in the GSV-precursor membranes were several potential ER residents including one that was known at the time only as a possible secreted protein (c10orf58) whose mRNA was expressed in human testes [28]. Its
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sequence revealed a CXXC motif, which is the active site sequence of an oxidoreductase [6, 21]. We determined by qPCR that its mRNA was expressed in mouse testes, but we also saw that mRNA expression in brown and white fat was an order of magnitude higher than in any other
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mouse tissue except testes (data not shown), which we confirm here for protein expression (Figure 1). Consequently, we are calling this molecule adiporedoxin (Adrx), and we show here
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that it plays an important role in the assembly and secretion of disulfide-bond containing proteins, in particular, adiponectin in murine and human cells and adiponectin and collagens in murine cells. Its absence in mice leads to a complex and mixed phenotype of lower adipokine secretion and lower adipocyte collagen deposition along with adipocyte ER stress and
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hyperinsulinemia.
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2. MATERIALS AND METHODS 2.1. Animals.
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Primary adipocytes from male Sprague-Dawley rats (175-200 g, Harlan Laboratories, Indianapolis, IN) were isolated and fractionated as described [27]. The same fractionation protocol was performed for 3T3-L1 cultured murine adipocytes. Age matched, 8 week old
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C7BL/6 male and female mice were purchased from Jackson Laboratory (Farmington, CT), maintained at 22°C with a light-dark cycle (light from 0700 to 1900h), and allowed free access to
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food and water. At 10 weeks of age, mice were body weight matched into groups fed either HF (45% of calories, mainly as lard) or LF (15%) diets, then sacrificed as described [29]. All females were euthanized at the pro-estrus phase. For Adrx tissue distribution, mice were perfused with PBS, tissues were carefully dissected with particular attention to removing any fat, immediately mechanically homogenized in a tissue grinder with RIPA buffer containing a
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protease inhibitor cocktail and subjected to a 1000 x g spin to remove debris. The supernatant was collected for SDS-PAGE and Western blot analysis. For fat tissue, the infranatant below the
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fat cake was collected for analysis.
The Adrx knockout mice were generated by microinjecting targeted ES cells (KOMP, derived
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from C57BL/6N, VG15730, clone 15730A-H5) into C57BL/6N blastocysts, and these gave rise to male chimeras with significant ES cell contribution (as determined by coat color). By mating with C57BL/6N females and genotyping the offspring by PCR analysis, germ line transmission was confirmed. Male and female heterozygous F1 animals were interbred to obtain Adrx knockout (Adrx KO) animals. Male animals only were analyzed at >8 weeks of age. The animals were maintained in a pathogen-free animal facility at 22°C under a 12-h light/12-h dark cycle with access to a standard rodent chow. Except when specifically noted, all mice used for in vivo 7
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or in vitro studies were fasted for 4-6 hours starting from early morning prior to use. For tissue harvesting, mice were sacrificed under CO2 anesthesia, and tissues were rapidly taken and immediately frozen in liquid nitrogen and stored at -80°C until biochemical analysis. Tissue and
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cell secreted collagen content was measured using Sirius Red Total Collagen Detection Kit (Chondrex, Redmond, WA, #9062). Mouse serum total and HMW adiponectins were measured
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by using ELISA kit from ALPCO (Salem, NH, #47-ADPMS-E01). 2.2. Primary human adipose cells.
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Human adipose stromal vascular cells (SVC) were isolated from adipose tissue by collagenase digestion, grown and differentiated as previously described [30]. Adipocytes (day 10 post differentiation) were transfected with control or a combination of two Adrx-directed siRNA (SI04213587 and SI04959066, Qiagen, Hilden, Germany) using Lipofectamine and PLUS
2.3. Cell Culture.
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reagents (Life Technologies, Carlsbad, CA).
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Murine 3T3-L1 cells were cultured, differentiated, and maintained as described previously (Stephens et al., 1997). Human embryonic kidney (HEK)-293T cells were cultured in DMEM
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with 10% FBS. For Adrx overexpression, confluent 3T3-L1 fibroblasts were infected with a pBABE retrovirus construct driving Adrx cDNA using the following oligo primers: sense sequence containing BamH1 restriction site, 5’-ttttggatccatgtcttttctccaggac-3’ and an antisense sequence containing an EcoR1 restriction site, 5’ttttgaattctcagcttctcccggacgctggagt-3’, then differentiated for subsequent analysis as fat cells. Site directed mutagenesis of Adrx was performed using a Quickchange Mutagenesis Kit (Agilent, Santa Clara, CA) following the manufacturer's instructions. 8
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For Adrx silencing, mouse lentiviral vectors driving several shRNA sequences were purchased from Open Biosystems (Huntsville, AL) and transfected into HEK-293T cell with trans-IT 293 (Mirus, Madison, WI) according to the manufacturer’s instructions. Supernatant containing
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retrovirus was harvested 48 hrs later and used to infect confluent 3T3-L1 fibroblasts prior to their differentiation. Four pLKO.1 c10orf58 mouse lentiviral vectors were tested. All sequences were effective with target # 3 showing the best knockdown efficiency (>90%), and it was used for all
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of the adiporedoxin studies.
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2.4. QPCR.
Total RNA was isolated, quantified and reverse-transcribed using a commercial cDNA synthesis kit. Quantitative PCR (qPCR) was performed with commercially available TaqMan probes (Thermo Fisher Scientific) or SYBR primers. Primer sequences will be available upon request.
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2.5. Gel Electrophoresis and Immunoblotting. Proteins were resolved by SDS-PAGE as described [31]. Non-denaturing PAGE separation of
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adiponectin oligomers was performed as described [13]. Gels were transferred to polyvinylidene difluoride (Biorad, Hercules, CA) membranes pretreated with methanol in 25 mM Tris, 192 mM
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glycine. Membranes were blocked with 10% nonfat dry milk in PBS containing 0.1% Tween 20 for 1 hour at room temperature. Membranes were then probed with the primary antibodies for either overnight at 4 °C or 2 hrs at room temperature and incubated with Horseradish peroxidaseconjugated secondary antibodies (Sigma-Aldrich, St. Louis, MO). Signals were enhanced with chemiluminescence reagents (Perkin Elmer Life Sciences, Boston, MA) for detection of Western signals using a Fujifilm LAS-4000 scanner or Autoradiography Film (Molecular Technologies, St. Louis, MO). Antibodies to the indicated proteins were from the following sources: GLUT4, 9
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cellugyrin, IRAP and Adrx (21st Century Biochemical, Hopkinton, MA); adipsin (Santa Cruz Biotechnology, Inc., Santa Cruz, CA); ERo1-α (Abnova, Taipei, Taiwan); adiponectin (Affinity Bioreagents, Golden, CO); β-actin, tubulin (Sigma-Aldrich, St. Louis, MO); DsbA-L and
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calnexin (Abcam, Cambridge, MA). Antibodies to the following were generous gifts: aP2 (Dr. David Bernlohr, University of Minnesota), insulin receptor (Dr. Jongsoon Lee, Joslin Diabetes
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Center). 2.6. Immunofluorescence.
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On Day 6 of differentiation, cells were trypsinized and plated onto coverslips in 6 well plates. On day 8 of differentiation cells were fixed with 4% paraformaldehyde in PBS for 15 minutes at room temperature and permeabilized with 0.1% saponin (Sigma-Aldrich, St. Louis, MO), 0.4% BSA in PBS (solution A) for 10 minutes and then blocked for 1 hour at room temperature in 5%
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normal goat serum (Sigma-Aldrich, St. Louis, MO) in PBS. Primary antibodies were incubated with fixed cells overnight at 4°C at a dilution of 1/100 in 1% normal goat serum in PBS. After staining cells were washed four times with solution A and incubated with Alexa-Fluor 488 anti-
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mouse or Alexa-Fluor 555 anti-rabbit (Life Technologies, Carlsbad, CA) at a dilution of 1/1000 in 1% normal goat serum in PBS for 1 hour at room temperature. The cells were washed again
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for 3 times with solution A and then mounted with Vectashield mounting medium with DAPI (Vector Laboratories, Burlingame, CA, USA). The stained cells were observed using a Nikon deconvolution wide-field Epifluorescence system and images were processed using NIH ImageJ software (http://imagej.nih.gov/ij/). 2.7. Mass Spectrometry. 2.7.1. Sample preparation and peptide TMT-labeling. Cultured adipocytes were lysed with a 10
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mechanical homogenizer, disulfide bonds were reduced with DTT, and cysteine residues alkylated with iodoacetamide essentially as previously described [32]. Isobaric labeling of the peptides was accomplished with six-plex tandem mass tag (TMT) reagents (Thermo Scientific,
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Rockford, IL). Reagents, 0.8 mg, were dissolved in 40 µl acetonitrile (ACN) and 15 µl of the solution were added to 100 µg of peptides dissolved in 100 µl of 50 mM HEPES, pH 8.5 After 1 hour at room temperature, the reaction was quenched by adding 8 µl of 5% hydroxylamine.
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Peptides were labeled with all six reagents (126-131), combined and subjected to C18 SPE.
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2.7.2. Liquid chromatography electrospray ionization tandem mass spectrometry (LCMS/MS).
All LC-MS/MS experiments were performed on an LTQ Orbitrap Velos (Thermo Scientific, Rockford, IL) equipped with a Famos autosampler (LC Packings, Sunnyvale, CA) and an
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Agilent 1100 binary HPLC pump (Agilent Technologies, Santa Clara, CA) as described [33]. 2.7.3. Data processing: MS2 spectra assignment, data filtering and quantitative data analysis
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Assignment of MS2 spectra was performed using the Sequest algorithm by searching the data against a protein sequence database containing all known translated proteins from the mouse IPI
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database (version 3.60), and known contaminants such as porcine trypsin, and human keratin. This forward (target) database component was followed by a decoy component including all listed protein sequences in reversed order. For quantification, the total signal intensity across all peptides quantified was summed for each TMT channel, and all intensity values were normalized to account for potentially uneven TMT labeling. The intensities for all peptides of a given protein were summed to derive an overall
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protein abundance value for each TMT signal. Hierarchical clustering using Pearsons correlational analysis was conducting using MultiExperiment Viewer (TM4 Microarray Software
performed using JMP statistical software (version 10 Pro).
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Suite) (Saeed et al., 2006) and Principle component analysis based on correlations was
Protein ratios across Adrx cell lines between KD to control and OE to control were calculated
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based on their normalized TMT ratios. Principle component (PCA) analysis, GO classifications and enrichment calculations were performed using DAVID online bioinformatics tools. The
Molecular
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resulting clusters are plotted for GO Cellular Components, GO Biological Processes and GO Function annotations. Representative proteins are highlighted with their
corresponding ratios. 2.8. Pegylation Assay.
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3T3-L1 cultured adipocytes at day 8 of differentiation were treated with 5 mM dithiothreitol (DTT) for 5 min, 3 mM diamide for 5 min, or various concentrations of H2O2 for 10 min. Cells were denatured and precipitated in ice-cold PBS containing 20% trichloroacetic acid (TCA),
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incubated on ice for 1 h, and centrifuged at 10,000 rpm for 15 min at 4°C. The supernatant was
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discarded and the pellet was washed 3 times with ice-cold acetone, dried, and resuspended in reaction buffer (80 mM Tris-HCl, pH 6.8, and 2% SDS) containing 5 mM methoxypolyethylene glycol (average molecular weight, 2000)-maleimide (MalPEG-2K) (NOF Corporation, White Plains, NY) [34]. Samples were left in the dark for 60 min at room temperature. The alkylation reaction was stopped by boiling for 5 min after the addition of an equal volume of 4X Laemmli loading buffer.
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2.9. Study approval. The animal studies were approved by the Institutional Animal Care and Use Committee and the human fat cells were obtained from subjects who gave informed consent
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as approved by Institutional Review Boards of Boston University School of Medicine.
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3. RESULTS: 3.1. Adiporedoxin (Adrx) is an ER protein highly expressed in white (WAT) and brown
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(BAT) adipose tissue and is induced during adipocyte differentiation. Figure 1A shows the sequences of mouse and human Adrx with their –CXXC- active sites (red) and transmembrane (TM) region/leader sequences (green underlined), both domains indicated in the cartoon of Figure 1B. Figure 1C and 1D show respectively, the tissue
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distribution of Adrx protein in mice and the time-dependency of its expression as a function of
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3T3-L1 adipocyte differentiation. As expected, Adrx protein expression was relatively high in testis, and although great care was taken in removing fat from the other tissues, traces of Adrx (compared to fat and testes) can be observed in small intestine and spleen, which probably reflects low level expression in those tissues (Figure 1C). Like many proteins that are highly expressed in adipocytes, GLUT4 for example [35], Adrx was markedly induced as preadipocytes
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differentiate (Figure 1D). Like the murine cells, cultured human adipocytes express Adrx mRNA and protein in a differentiation dependent fashion and its knockdown in these cells results in diminished adiponectin secretion (Figure S1). Adrx mRNA is also expressed in human adipose
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tissue to a much greater degree than in other human organs (Figure S1).
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We determined by sucrose gradient fractionation in primary rat adipocytes (Figure 1E) that Adrx was colocalized with the ER membrane marker, calnexin (Cnx) [36], and was well separated from GLUT4-rich vesicles. Its partial co-localization with cellugyrin (CG), a marker for diverse intracellular vesicles [37], accounts for its appearance in GSV precursor membranes that allowed its initial identification [27]. To put Adrx into the context of other possible ER contributors to fat cell ER function, disulfide bond formation and protein secretion, we subjected membranes from 3T3-L1 adipocytes to sucrose gradients and showed that Adrx overlaps 14
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significantly with proteins of the ER lumen, namely adiponectin (Adpn), ERo1α and PDIa1 (Figure 1F). These last three proteins are soluble and were partially released from the ER during cell fractionation and therefore migrated at the top of the gradient, whereas Adrx did not,
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confirming its integral membrane association. On the other hand, DsbA-L distributed only to the top of the gradient, indicating that it is unlikely to be a resident of the ER lumen. Lastly, we confirmed by immunofluorescence microscopy in 3T3-L1 adipocytes, the nearly complete co-
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localization of Adrx with calnexin, its partial localization with adiponectin and its minimal, if
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any, co-localization with porin [38], hence mitochondria (Figure 1G). 3.2. Adrx levels affect adiponectin and collagen secretion.
Given the CXXC motif of adiporedoxin and its ER localization, its role in disulfide bond formation and subsequent protein secretion seemed likely. Thus we generated Adrx knockdown
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and overexpressing 3T3-L1 cells (Figure 2A) and monitored secreted (Figure 2B-C) adiponectin and collagen (Figure 2D) comparing them to control (scrambled shRNA). As previously noted, adiponectin is found circulating in what are often termed low, medium and high molecular
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weight oligomers corresponding to trimer, the first formed disulfide-linked oligomer (LMW), hexamer (MMW) and larger oligomers (HMW) [14]. As shown in Figure 2B in a non-
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denaturing, non-reducing gel for 4 hours of secretion, all Adpn multimers were affected to the same extent by alterations in Adrx expression. That is, secretion is inhibited in the knockdown cells and enhanced in the over expressing cells as compared to controls and this is shown quantitatively in Figure 2D. As noted in the Introduction, adiponectin and collagen have some similar features, disulfide bonds, a triple helical region and post-translational modifications, and we also determined the effects of altered Adrx expression on collagen secretion. It is inhibited or enhanced, respectively, by Adrx knockdown and over expression (Figure 2D). Moreover, and 15
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like cultured fat murine cells (Figure 2B), siRNA mediated knockdown of Adrx in primary human adipocyte cultures inhibited the secretion of all adiponectin oligomers (Supplemental Figure 1). Thus, these aspects of Adrx biochemistry in vitro appeared identical in mouse and
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human fat cells.
If the overall effect of Adrx expression levels results in altered assembly of mature
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proteins, hence altered secretion, we would expect that cell-associated adiponectin would be enhanced by its knockdown and decreased by its over expression and this is exactly what we
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observe (Figure 2A). In addition, the insulin receptor which has numerous intra- and intermolecular disulfide bonds [39] also shows altered expression due to Adrx manipulation, as expected, less receptor in the knockdown and more in the over expressers (Figure 2E). In this case, it was the steady state levels of an integral membrane protein that were being altered.
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3.3 Adiporedoxin is a redox-regulated protein, which catalyzes the oxidation of ER
To directly confirm that Adrx functioned as a redox-regulated protein, we used N-
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ethylmaleimide PEGylation [40] to assay for changes in the adipocyte ER oxidation state as reflected by mobility shifts in Adrx and PDIa1. This reagent covalently reacts with reduced
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cysteines and retards protein mobility by 2K when run in non-reducing SDS-PAGE. As shown in Figure 3A, control cells exhibited a mixture of oxidized and reduced PDI and Adrx, and cells treated with the strong oxidizing reagent diamide [41] showed fully oxidized proteins and cells treated with the reducing agent, dithiothreitol (DTT), showed reduced mobility due to PEGylation. As a control, a mutant Adrx (SFLS) lacking the two active site cysteines did not show this shift (Figure 3A, right hand panel).
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To determine if Adrx could affect protein secretion through re-oxidation of chaperone proteins, we determined the redox state of PDIa1 in cells over and under expressing adiporedoxin (Figure 3B & 3C). Knocking down Adrx decreased the oxidized form of PDIa1 in
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the basal state and in response to all doses of hydrogen peroxide (Figure 3B). Overexpression of Adrx caused a slight but statistically insignificant increase in the oxidized forms of PDIa1
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(Figure 3C) consistent with the enhanced secretion under these conditions. 3.4. Adrx expression levels affect the adipocyte proteome
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We used Tandem Mass Tag technology (TMT) and quantitative mass spectrometry [42, 43] to interrogate the proteome of control 3T3-L1 adipocytes (CON) and Adrx overexpressing (OE) and knockdown (KD) adipocytes. Overall, we were able to identify ca. 4500 proteins at a 1% protein false discovery rate (Supplemental Table S1). Principal component analysis (Figure
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4A) of the proteomic data shows good agreement between the biological replicates, and we observed that the majority of the proteome was unaffected by Adrx expression. Figure 4B shows a heat map of all proteins quantified and Gene ontology (GO) enrichment analysis for proteins in
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the overexpressing cells showed a significant increase in cell associated oxidoreductase and thioredoxin-related proteins and decreases in secreted adiponectin and collagen (Figure 4C), the
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latter two as would be expected from the data of Figure 2. Thus the amount of cell-associated, disulfide-bonded adipokines, adiponectin (Adpn) and resistin (Rtn) [44, 45] was less than in controls in the Adrx overexpressing cells and increased (cell retention) in the Adrx knockdown cells. On the other hand, serum amyloid A3 protein, which lacks S-S bonds [46], does not change as a result of altered Adrx expression (Figure 4C). The expression of the three specific collagen chains indicated in Figure 4C (see also Supplemental Tables S1 and S2) were affected by
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alterations in Adrx levels in a manner similar to adiponectin in confirmation of the biochemical analysis of Figure 2D.
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3.5. Adrx null mice show decreased adipokine secretion, have mild ER stress and are hyperinsulinemic.
In order to obtain data for the effects of Adrx levels in vivo, we introduced into mice ES
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cells obtained from KOMP for a gene construct that deletes exons 2-6, and we generated Adrx knockout mice. The mRNA expression for WT, heterozygous and Adrx null mice is shown in
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Figure 5A and protein expression data for the WT and knockouts are shown in Figure 5B and quantitatively analyzed in Figure 5C. The mice exhibited increased adiponectin retention and increases in components of the ER protein maturation machinery, BiP and ERo1α (Figure B, C) as well as in a number of mRNAs encoding ER stress proteins and inflammatory markers
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(Supplemental Figure S2). Mass spectrometric analysis of intact epididymal fat tissue from WT and Adrx knockout mice confirmed that adiponectin and other adipokines show higher cellular levels (enhanced retention implying reduced secretion) in the knockout as compared to WT
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(Supplemental Table S2), The WT and null mice are the same weight (Figure 5D) and body composition (Figure S3B, S3C), and the nulls have decreased levels of circulating HMW
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adiponectin (5E) as was expected from the in vitro data (Figure 2 and 3). The knockout mice have normal blood glucose (5F) are mildly hyperinsulinemic (5G), but have normal glucose tolerance (5H).
3.6. Adrx null mice are protected from fibrosis due to decreased collagen deposition. Remarkably, while the epididymal adipose tissue from WT mice at age months 7 stains strongly for collagen deposition, the epididymal adipose tissue from Adrx null mice is essentially 18
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free from fibrosis (Figure 5I), and as determined by mass spectrometry (Supplemental Table S2), the Adrx null mice had lower levels of 14 collagen isoforms including collagen chains 6a1, a2, a3 & a5, the most abundant species we detected in adipose tissue (see also Figure 4C and [47]).
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Biochemical analysis of total collagen confirmed the mass spectrometry data (Figure 5J). Thus the in vivo collagen expression data are consistent with the adipose tissue staining (Figure 5I) and the results from the in vitro mass spectrometry analysis and quantification (Figure 2C and
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4C). Interestingly, at age 6-7 months, the Adrx null mice are the same weight and body
fasting insulin (Supplemental Figure S3).
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composition as wild type mice, have identical glucose tolerance but have significantly higher
3.7. Adrx is expressed in human adipocytes and down regulated in proportion to the level of inflammation.
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Adrx mRNA in human adipose tissue was tightly correlated with adipose tissue adiponectin mRNA in both sexes (Figure 6A, males, 6B, females) after statistical adjustment for BMI, which had a negative effect on adiponectin mRNA (Figure 6A & B, right panels). A
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similar correlation was noted for Adrx protein and tissue adiponectin, independent of BMI R=0.53, p<0.01 in males; 2R=0.49, p<0.0001 females, data not shown). In addition, tissue Adrx
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protein levels were inversely related to the ratio of pJNK to total JNK protein for fat cells of both sexes (Figure 6C), pJNK being a marker of inflammation in human adipose tissue [48], and this association was independent of BMI in multiple regression models (data not shown). Lastly, male wild type mice fed a high fat diet showed elevated adipose inflammation [49] and also showed reduced Adrx levels and reduced circulating adiponectin, whereas females do not show any changes in these parameters (Supplemental Figure S4).
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4. DISCUSSION: We describe herein the actions of adiporedoxin (Adrx), a novel protein highly enriched in
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adipocytes and localized to the endoplasmic reticulum, whose altered expression in vitro in mouse and human cells, and in vivo in mice, results in significant changes in adipocyte protein secretion. In particular, its knockdown in mouse and human fat cells resulted in a significant
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attenuation of adiponectin secretion (Figures 2, 4 and S1), a protein whose expression has been linked with insulin sensitivity [50] and the secretion of collagens (Figure 2, 4, 5 and Supp. Table
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2), proteins which can cause adipocyte fibrosis and insulin resistance [19, 51]. Both types of proteins require disulfide bonds for assembly and secretion. Moreover, we showed by proteomic analysis that Adrx over and under expression enhanced and attenuated, respectively, the secretion of several S-S bonded adipokines including resistin (Figure 4) and adipsin (Western blot not shown) as well as affected insulin receptor amounts (Figure 2), the latter presumably due
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to its large number of disulfide linkages [39]. As most secreted proteins have disulfide bonds, appropriate controls are scarce for the measuring the effects of Adrx on secreted proteins lacking disulfides. However, serum amyloid A protein is such a protein [46], and its secretion is in fact
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unchanged in by manipulation of Adrx expression (Figure 4). Importantly, we confirmed much
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of the protein secretion data in studies of Adrx null mice (Figure 5), which circulate lower levels of HMW adiponectin and are remarkably free of fibrosis due to impaired collagen secretion. Lastly, Adrx protein levels in human fat tissue correlate well with adiponectin protein levels, and inversely with cellular inflammatory markers regardless of BMI. Thus higher levels of Adrx contribute to the maintenance of healthy adipose tissue despite obesity (Figure 6). The data we obtained are consistent with Adrx acting at an early step in the secretory pathway of adipocytes. Thus reduced Adrx expression in the context of ER oxidative stress 20
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(hydrogen peroxide, Figure 3) results in impaired redox regulation of PDIa1, the most abundant adipocyte chaperone found in our proteomic analysis of mouse adipose tissue (Supp. Table 2), which is directly involved in disulfide bond formation [21]. Adrx appears to be in the
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peroxiredoxin (Prx) family of redox-regulated proteins [52] that have diverse biological functions in a variety of cell types, reduction of peroxides being their eponymous activity [53]. The only other endoplasmic reticulum localized peroxiredoxin, Prdx4, functions in the formation
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of disulfide bonds indirectly, probably by regulating the amount of reactive oxygen species, principally hydrogen peroxide [54, 55]. As noted, disulfide bond formation is directly mediated
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by protein disulfide isomerases (PDIs) whose active sites have two or three -CGHC- sequences along with a chaperone fold consisting of about 130 amino acids with four beta sheets and 3 alpha helices [21]. The PDIs bind to substrates, form and if necessary, reform and correct their disulfide bonds, although many details of the process remain unclear [34]. On the other hand,
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adiporedoxin has a unique thioredoxin active site sequence, -CFLC-, not found in other PDI/Trx proteins, nor in the other peroxiredoxin family members, including Prdx4, as peroxiredoxins have cysteines widely separated in their primary protein sequences and function as multimers
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[53]. Moreover, unlike most members of the PDI family and Prdx4, which are soluble in the lumen of the organelle, Adrx is a transmembrane protein (Figure 1) similar to the transmembrane
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thioredoxin-like protein 4 (TMX4) only with respect to its ER membrane location [40, 56]. Based on the data of Figure 3, we hypothesize that Adrx has a function unique to
adipocytes that likely involves its ability to deal with metabolically related ER oxidative stress and to mediate protein secretion under these conditions. Recent related work on the role of various ER proteins involved in oxidative protein folding and disulfide bond formation has revealed redundancies and complementary roles for multiple PDI/Trx-related proteins [34, 55],
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fourteen of which are expressed in the adipocyte ER (Supplemental Tables S1, S2, see also [47]). The relatively modest metabolic phenotype of the Adrx null mice, similar in that respect that to the ERo1α/ERo1β knockout [57], likely reflects this complexity and redundancy in ER
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oxidoreductase function. On the other hand, the biochemical phenotype of the Adrx null mouse with regard to collagen secretion is particularly robust. Thus, considerable additional work will be required to define the biochemical role of Adrx more precisely and its hierarchical role in
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adipocyte ER redox regulation, and this is in progress. Adrx has previously been reported in one publication naming it peroxiredoxin 2-like protein expressed in bone marrow monocytes
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(PAMM, also known as Fam213a) [52] that affects cellular redox status, a result consistent with the present data. Its expression in fat tissue was not examined in the cited study, but the authors showed protein to be expressed in human liver, brain and other tissues, at what appears to be one or more orders of magnitude lower than in adipocytes, as compared to our data on Adrx levels in
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these mouse tissues (Figure 1). These authors showed a minor extent of PAMM mRNA upregulation and protein in macrophage colony-stimulating factor activated bone marrow monocytes in vivo, but subsequent verification of its redox function was performed in transfected
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established.
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cells in vitro. Thus a physiological function in vivo for PAMM in monocytes was not definitively
A second aspect of Adrx function in adipocytes concerns the biochemical nature of the
most abundant secreted molecules of these cells, adiponectin and collagen. These proteins are particularly interesting, not only for reasons of their abundance and important physiological role(s), but also for the fundamental biochemistry and cell biology of their complicated quaternary structures, post translational modifications including intermolecular disulfide bond formation [16, 58]. The adiponectin trimer consists of an intermolecular disulfide link between 2
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monomers and a free SH group on the 3rd subunit, which is then disulfide bonded to another trimer to form the hexamer [12, 59, 60]. Likewise, intrachain disulfide bonds between the N- and C-terminal propeptide sequences are necessary to form the signature triple helix structure of
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collagens [58] before their movement out of the ER. The striking biochemical phenotype of the Adrx knockout mouse emphasizes Adrx’s roles as a particular modulator of collagen secretion and that of related proteins. Regarding adiponectin, previous studies have documented a direct
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interaction of an adiponectin cysteine residue with one in ERp44, which bond can be released by reducing agents or by increasing ERo1α levels [24]. This mechanism, enhanced retention, is
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analogous to the assembly of IgK [61, 62]. However, adipsin has only intermolecular disulfides [63] and the insulin receptor has both types of bonds [39]. This would support the above stated notion that Adrx plays a broad role early in disulfide bond formation, e.g. ER redox status, such that a compromise in its activity reduces the overall levels of most or all disulfide bonded
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integral membrane and secreted proteins. DsbA-L was shown to directly interact with adiponectin in yeast-2 hybrid studies and to promote its multimerization [26]. DsbA-L was also shown to alleviate the effects of adipocyte ER stress on adiponectin levels [64], but it does not
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appear to be a luminal ER resident (Figure 2), presumably a requisite for a direct role in oligomer assembly, and its knockout in mice is without effect on adiponectin multimerization [65]. Thus a
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further examination, in vitro and in vivo, of the possible players in adipocyte protein secretion is needed to resolve the specific roles of these proteins in the formation of adipokines and integral membrane proteins and to further elucidate their mechanism(s) of action. Given its pleiotropic action on adipokines and other secreted proteins related to insulin sensitivity, the relationship of Adrx levels to pathophysiological states in mice and humans is likely to be complex. Indeed, we see no dramatic effects of Adrx deficiency on systemic glucose
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utilization in null mice on a chow diet (fasting glucose and glucose tolerance, Figure S3). However, lower circulating HMW adiponectin levels and mild hyperinsulinemia would suggest some degree of insulin resistance. Moreover, fibrosis, while present in WT animals, is virtually
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absent in the epididymal fat pad of older Adrx deficient mice, and this should enhance the metabolic flexibility and the insulin sensitivity of adipose tissue and the entire mouse and, therefore, could compensate for the effects of hypoadiponectinemia and hyperinsulinemia at least
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with regard to glucose tolerance. In human adipose tissue we also found a close correlation between Adrx and adiponectin levels in both men and women, independent of BMI.
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Furthermore, higher expression of activated (phosphorylated) JNK, a marker of ER stress, inflammation and insulin resistance [48] was inversely correlated with Adrx protein (Figure 6C). In WT male mice following 12 weeks of a high fat diet, which results in insulin resistance, reduced adipocyte Adrx protein correlates with lower circulating adiponectin (Supplemental
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Figure S4). Taken together, the data from mice and humans point to a positive effect of Adrx protein levels in ameliorating insulin resistance, although the relative contribution(s) in this regard of adipocyte secretory proteins downstream of this protein remain to be fully elucidated.
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Thus, we postulate that Adrx may be down regulated in response to the metabolic and inflammatory status of adipose tissue and this mechanism contributes to lower adiponectin levels
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in obese humans, which is likely to be one of several factors influencing the metabolic status of the individual. In summary, adiporedoxin is clearly an important contributor to fat cell biology in mice and humans and one that participates in and regulates novel aspects of the secretory pathway in these cells of relevance to basic cellular functions, organismal metabolism and pathology.
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ACKNOWLEDGMENTS We thank Dr. Tsu-shuen Tsao, University of Arizona for help with the non-denaturing gels for
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adiponectin and Dr. Alessandro Peschechera for critical reading of the paper. This work was supported by the NIH: DK-30425 and DK-092942 to PFP; DK-52398, DK-080448, P30 DK046200 to SKF; DK104369 to SKF and PFP and HG3456 to SPG. The authors declare no
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competing financial interests. Appendix supplementary data
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The following are the supplementary data related to this article Supplementary Table 1
Supplementary Table 2
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Proteomic analysis of 3T3-L1 cells over and under expressing adrx.
Selected proteins from a TMT proteomic analysis of epididymal adipose tissue from WT and
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adiporedoxin null mice
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Supplementary Figure 1
Adrx expression in human adipocytes parallels that in mouse fat cells and affects adiponectin secretion. The mRNA distribution of Adrx A. and adiponectin B. in abdominal subcutaneous adipose tissue (AT), and isolated fat cells (FC) and stromal-vascular fractions (SVF) obtained after collagenase digestion is shown in comparison to the other tissues lindicated (n=3). C. Adrx mRNA and protein shows a marked increase in expression during the differentiation of human preadipocytes. The data are expressed as % of one of the 4 cultures that was set to an arbitrary
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value of 1. D. (I.-IV.) shows that knockdown of Adrx mRNA and protein did not decrease adiponectin mRNA, but markedly decreased the secretion of (HMW) and lower molecular weight forms (MMW and LMW) into the medium. The data in all panels are representative of 3
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or more independent experiments. The data in panel D were reproduced in cells from 2 individuals.
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Supplementary Figure 2
Figure S2 related to Figure 5 mRNA Expression of adipocyte ER stress and inflammation
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markers in the Adrx null and wild type mice. A. ER stress markers (HERP: homocysteineinduced ER protein; CHOP: CAAT/enhancer binding protein (C/EBP) homologous protein; EDEM1: ER degradation enhancer, mannosidase alpha- like 1; WARS: tryptophanyl tRNA synthetase; P58IPK: p58 inhibitor of interferon-induced double-stranded RNA-activated protein
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kinase) and B. Inflammatory markers were measured by RT-qPCR from 8-week old adrx null and wild types mice adipose tissue.
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Supplementary Figure 3
Metabolic characteristics of 7 months old Adrx null mice. Body weight growth (A), Body
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composition lean (B) and fat (C) mass, fasting serum glucose (D) and insulin (E) and glucose tolerance (F) were measured from 7- month old adrx null and wild type mice. Supplementary Figure 4
Adiporedoxin expression is reduced in epididymal adipose tissue from obese, high fad fed (HFD) male mice. A. Male (6/condition) and female B (5/condition) were fed a "chow” (LFD) diet or a HFD for 14 weeks and the expression of the indicated proteins in white adipose tissue lysates
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was determined by immunoblotting following SDS-PAGE. B. The gels were scanned and quantitatively analyzed as in other figures (mean +S.E.M., p< 0.05, n = 6). C. Serum HMW adiponectin was measured in the mice from A and plotted as the ratio of HMW/total adiponectin
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normalized to adipocyte Adrx/tubulin.
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FIGURE CAPTIONS Figure 1. Adiporedoxin (Adrx) is an endoplasmic reticulum targeted peroxiredoxin-related
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protein enriched in adipocytes. A. The sequences and domains B. of mouse and human adiporedoxin are shown, highlighting the transmembrane region and the active site cysteines C. The tissue distribution of adiporedoxin
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and adiponectin (Adpn) is shown for equal protein amounts of cell lysates subjected to SDSPAGE and Western blotting detection. D. Adrx protein expression is induced during 3T3-L1 cell
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differentiation from fibroblasts (day 0) to mature fat cells (day 8). An equal protein amount of cell lysates from the days indicated was subjected to SDS-PAGE and immunoblotted for the selected proteins. E. The internal membrane fraction (0.5 mg protein) from isolated primary adipocytes was subjected to sucrose gradient centrifugation; odd-numbered fractions were collected and blotted for the proteins indicated, adiporedoxin (Adrx), calnexin (Cnx), cellugyrin
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(CG) and GLUT4. F. 3T3-L1 cells were lysed, processed and subjected to sucrose gradient analysis as for the primary adipocytes of 1e. Additional proteins analyzed are adiponectin (Adpn), disulfide bond A oxidoreductase-like (DsbA-L), endoplasmic reticulum oxidoreductase
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1-alpha (ERo1α). G. Immunofluorescence of differentiated 3T3-L1 cells comparing the
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localization of Adrx with calnexin, adiponectin (Adpn) and porin. The data for each part of this figure are representative of three or more independent experiments.
Figure 2. Adiporedoxin levels affect the secretion of adiponectin (Adpn) and collagen, and the insulin receptor (IR) levels. Day 8 differentiated murine adipocytes (3T3-L1) infected with Adrx shRNA, WT Adrx cDNA (OE) or a scrambled sequence (-) were washed 3X with serum free medium, and then incubated
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for 4 hours (A-D). Cell lysates and supernatants were harvested, subjected to SDS-PAGE and Western blotted for the indicated proteins. A. Shown is a representative experiment for Adrx knockdown and over expressing cells where lysates were prepared and subjected to SDS-PAGE
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under reducing conditions showing the total cellular levels of Adrx, Adpn and the insulin receptor (IR), actin as the loading control. B. Cell supernatants from a representative experiment were collected from control (-), knockdown (shRNA, +) and Adrx overexpressing cells (OE, +)
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after 4 hours and subjected to non-denaturing, non-reducing gel electrophoresis, the forms as indicated (HMW, MMW and LMW). C. The results of scanned gels for the 3 forms shown in B
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are given as the S.E.M., n=3, P< 0.001 for the over expressers and n=9, P< 0.002 for the shRNA cells, control value set to %100. D. Collagen secretion was measured in a separate series of experiments as in A and the results are from n=6, *P< 0.05. E. Western blotting data for the insulin receptor beta subunit following SDS-PAGE were scanned and statistically analyzed (n=4,
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*p <0.02, **p <0.002).
Figure 3. Adiporedoxin is upstream of PDI in the adipocyte ER redox cascade.
EP
A. 3T3-L1 cells over-expressing WT Adrx (CFLC) or with active site cysteines mutated to serines (SFLS) were treated or not with dithiothreitol (DTT), Diamide (Dia.) or not for 5
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minutes, lysed with 20% TCA, and TCA precipitates were reacted with MalPEG-2K to modify free cysteines. Adrx and protein disulfide isomerase a1 (PDIa1) were visualized by immunoblotting following gel electrophoresis of the TCA precipitates and the reduced and oxidized forms indicated. B. 3T3-L1 cells expressing scrambled or Adrx-targeting shRNA were treated with the indicated concentrations of H2O2 for 5 min., lysed and treated as in Figure 3A.
37
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The bar graph on the right shows the mean ± S.D. for scans of 4 independent experiments (*p< 0.05). C. Same as Figure 3B for Adrx over expressing cells and controls (scrambled shRNA).
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Figure 4. Proteomic analysis of tandem mass tagged (TMT)-labeled whole cell (3T3-L1) lysates confirms Western blot data and reveals pleiotropic cellular changes as result of altered Adrx levels.
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A. Principle component analysis (PCA) analyses of the TMT labeling (Table S1) showed good correlation between biological replicates. Eigenvalues and percentages were calculated for each
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PCA. Graphical representation for each protein by PCA 1 and PCA 2 show the majority of the proteins did not change as a result of altered Adrx levels. Biplots of PCA 1 and 2 show a vector location of each biological sample where the biological duplicates were found to be most similar to each other. B. Heat map showing enrichment of Gene Ontology (GO) categories across Adrx
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cell lines. Indicated to the right of the heat map are those categories that were significantly enriched with Benjamin-Hochberg corrected p < 0.05. C. Relative amounts of cell associated adipokines (adiponectin, Adpn; resistin, Rtn; serum amyloid a, SAA) and selected collagens
EP
(Col1a, 3a, 6a) from Adrx knockdown (KD) and overexpressing (OE) as compared to control (Cont-set to 1.0). The results shown for the TMT experiment compare 2 dishes of each cell line
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(OE, KD, Cont, see Supplemental Table 1) and the entire experiment was repeated twice with similar results.
Figure 5. Adrx null mice show ER stress, hyperinsulinemia and their adipose tissue is free of fibrosis.
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A. Adrx mRNA levels from adipose tissue were examined by RT-qPCR from wild type (WT), heterozygote (Het) and Adrx knockout (KO) mice. B. Whole adipose tissue lysates from WT and KO mice were prepared in RIPA buffer. Protein (10–50 µg, equal amounts, WT & KO) was
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subjected to SDS-PAGE and immunoblotted with the indicated antibodies. C. Quantification of Adrx, Adpn, Bip and Ero1α from 6B, body weight (D), fasting serum insulin (E) and glucose (F), HMW adpn (G), and glucose tolerance test (H) were assessed in WT and Adrx KO mice. I.
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Collagen Masson's Trichrome Stain and J. collagen quantification by using Sirius Red Total Collagen Detection Kit of adipose tissue from WT and Adrx KO mice. 8-week-old strain-
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matched males were used in (a-h), n=3, and 7 months old mice were used in (I-J), n = 6. The statistical values are displayed as means and S.E. (*p < 0.05, **p < 0.01, ***p < 0.001).
Figure 6: Expression of adiponectin and adiporedoxin mRNA positively and strongly
kinase (pJNK) levels.
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correlate independent of BMI and Adrx protein negatively correlates with phospho-jun
EP
Figure 6 shows mRNA levels of Adrx and adiponectin in men (A) and women (B). Associations were analyzed in a least squares model that including the interaction term
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Adrx*BMI which was significant in the females (p=0.01) but not in the males (p=0.12). The model predicted 60% of the adiponectin variance in the females (R2 = 0.60, n = 30, p<0.001), and 62% in males (R2 = 0.62, n = 16, p< 0.01). C. Quantitative analysis of Western blots of adipocyte lysates for the ratio of p-JNK to total JNK, plotted versus Adrx for both sexes, shows a negative correlation in both males (r = -0.68, n = 16) and female subjects (r = -0.49, n = 29, one outlier excluded).
39
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Figure 1.
SMGMWSIGVG EKNGAVIMAV EIFLDEKKKF KQGILLEHRE
Human Adrx Sequence 1 61 121 181
MSFLQDPSFF PRTFKAKELW VKDFQPYFKG LGGVFVVGSG
B.
C.
14 28
85 88
TM
-CFLC-
LANTDMFLSK EAADLMSLKP MGLIRLGVWY SVLEAVKKIK
PRKAALEYLE DIDLKTLEKE KLDELGVPLY AVVKEQVKRE NSFRAWNGGF SGNLEGEGFI LQTPASGRS
ALGAAALALL RRPGCFLCRE YGPQRRKMMF KEFGDKVNLL
LANTDVFLSK EAADLSSLKS MGFIRLGVWY SVLEAAKMIK
PQKAALEYLE DIDLKTLEKE MLDQLGVPLY AVVKEHIRTE NFFRAWNGGF SGNLEGEGFI PQTLASEKK
Adrx
Bottom
Adrx
Adpn
AC C
CG
F.
Top
EP
Cnx
GLUT4
D.
TE D
Adrx
CO2H
Day Adrx
0
2
4
6
8
GLUT4
Adpn
E.
229
W AT BA T Lu ng Li ve r Br ai n He ar t M us c St le om a Sm ch al lI nt es Ki dn tin ey e Sp le e Te n st e Pa s nc re as
NH2
TMGMWSIGAG EKNGAVIMAV EIFLDEKKKF KQGILLEHRE
AVGAAAVALL RRPGCFLCRA YGPERRKMMF KEFGDRVNPL
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MSFLQDPSFF PRTFKAKELW VEDFQPYFKG LGGVFVIGSG
SC
1 61 121 181
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A. Mouse Adrx Sequence
Bottom
Top
CG
G.
Adrx Adrx
Porin
Merge
Adrx
Adpn
Merge
Calnexin
Merge
DsbA-L Ero1-α PDIa1 GLUT4
Adrx
ACCEPTED MANUSCRIPT
Figure 2.
-
Adrx
Cell Associated shRNA OE
-
+
Secreted Adiponectin
B.
shRNA
-
+
-
+
IR
Control
shRNA
250
100
*
0.00
150
A.U.
100
LMW
*
Control
shRNA
Control
OE
*
shRNA
**
50 0
100 0
Collagen Secretion
EP
0.50
*
50
MMW
1.50 1.00
*
150
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HMW
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µ g / µ g protein
2.00
*
*
50 0
*
200
A.U.
A.U.
150
LMW
Over Expression
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Control
Insulin Receptor
µ g / µ g protein
250 200
E.
HMW
SC
Actin
D.
+
MMW
Adpn
C.
OE
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A.
1.50
HMW
MMW
LMW
Collagen Secretion *
1.00 0.50 0.00
Control
OE
ACCEPTED MANUSCRIPT
Figure 3. Adrx CFLC
Reduced
PDIa1
Reduced
Adrx SFLS
Reduced
PDIa1
Reduced
Oxidized
Oxidized
Oxidized
Oxidized
l Adrx shRNA
SC
T
T
l ro nt Co a.
Di
DT
ro nt Co a.
Di
DT Control
B..
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A..
Oxidized PDI
Adrx
M AN U
Reduced Oxidized
Reduced
PDIa1
Oxidized
Control
0 0.1 1.0 5.0
H2O2 (mM)
shRNA
*
DTT Dia. 0
H2O2 (mM)
EP a. T
H2O2 (mM)
Di
0.1 1.0 5.0
DT
T
0
a.
Di
DT
AC C
PDIa1
0%
Adrx OE
Adrx
Control
50%
0 0.2 1.0 5.0
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a.
Di
H2O2 (mM)
T
C..
DT
T
a.
Di
DT
0 0.2 1.0 5.0
100%
*
0.2 1.0 5.0
H2O2 (mM)
Oxidized PDI Reduced 100%
Oxidized
50%
Reduced
0%
Oxidized
Control
DTT Dia
Over Expressing
0
0.1 1.0 H2O2 (mM)
5.0
ACCEPTED MANUSCRIPT Figure 4. B.
SC
Component 2 (18.3%)
Collagen
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Secreted
Component 1 (50.6%)
EP
C.
AC C
Component 2 (18.3%)
OE1 OE2 KD1 KD2 CON1 CON2
RI PT
A.
Component 1 (50.6%)
0.2
1
Oxidoreductase Thioredoxin/ Glutathione
4
3
KD/CONT
OE/CONT
2
1
0
Adrx
Adpn
Rtn
SAA
Col1a2 Col3a1 Col6a3
ACCEPTED MANUSCRIPT Figure 5.
***
50 0
WT
D.
Het
0
Bip
Body Weight
300 200
Ero1A
30.0
100
(g)
KO
F.
HMW Adpn
150
(mg/dl)
(ng/ml)
4.0
100
**
2.0 0.0
WT
H.
0
I.
KO
WT
(mg/dl)
400
0
100
150
Collagen Content
120 100 80 60 40 20 0
(%)
50
AC C
J.
EP
200 0
**
WT
WT
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WT
50
KO
IPGTT
600
Fasting Glucose
KO
KO
KO
**
100
0
KO
Bip
**
300
WT
G.
KO
WT
0.4
200
0
WT
*
WT
*
100
0.2 0
KO
Ero1α
Fasting Insulin
(ng/ml)
WT
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0.0
***
WT
0
10.0
Adpn
200
SC
20.0
E.
50
Adpn
KO
300
100
Tubulin
***
Adrx
150 (%)
(%)
100
KO
(%)
Adrx
150
WT
(%)
Adrx mRNA
C.
RI PT
B.
(%)
A.
KO
KO
ACCEPTED MANUSCRIPT Figure 6.
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Females
AC C
C.
EP
TE D
B.
SC
RI PT
A. Males
ACCEPTED MANUSCRIPT
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ER Redox Status
PDI
Adrx
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SC
Endoplasmic Reticulum lumen
---S-S---
Disulfide bond Formation
Mature Proteins
PM
AC C
EP
TE D
Protein Folding
Adiponectin… Benefical factors
Protein secretion
Collagen/Fibrosis, IR Contributors...
Human/mouse Physiological Metabolic Regulation
ACCEPTED MANUSCRIPT
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• Adrx is an adipocyte specific, endoplasmic reticulum oxidoreductase
SC
upstream of disulfide bond formation.
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• Adrx over and under expression in vitro results enhanced and decreased protein secretion, respectively.
decreased fibrosis.
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• Mice lacking Adrx have lower levels of circulating adiponectin and
AC C
EP
• In humans, mRNA and tissue levels of Adrx and adiponectin protein are positively correlated and elevated adipose inflammation correlates with reduced Adrx protein.
ACCEPTED MANUSCRIPT
n # 600 390 322 285 269 228 216 210 204 200 195 191 186 183 175 175 174 166 161 160 157 156 149 148 133 133 126 120 118 116 115 111 108 106 105 103 102 101 100 100 97 94 93 93 92 91 91 91 87 86 85 84 83 82 82 82 81
of
pe
s CO 42166.9 22153.9 9629.91 14945.6 18994.7 9642 12092.6 12115.9 12416.6 9183.57 9536.64 9887.59 7285.94 10204.8 5943.53 10566.9 8769.35 3308.67 8192.66 9286.89 7573.82 8909.09 8561.17 7755.67 7540.19 6379.82 5700.12 5001.7 6079.87 5564.35 8108.26 4179.54 5011.63 4683.67 5578.89 6810.84 5509.01 5609.74 5130.77 3277.86 5146.53 3403.7 5236.51 4490.02 3505.86 5284.43 5030.46 4681.62 4556.88 3666.2 3315.1 4906.89 4438.89 4642.9 4446.3 5670.47 4212.68
RO NT
L1 CO 51253.2 20992.4 10378 15316.4 15697.5 9855.63 11950.7 10602.4 11167.4 9884.6 8907.74 10775.6 8081.62 7479.45 5081.69 8305.87 8046.16 4165.25 6265.95 10254.3 6450.38 9864.98 7501.87 8426.27 6104.62 6379.82 4769.57 5039.55 5299.87 5383.98 6290.62 3549.26 6220.27 4027.42 6382.25 5084.62 5645.63 4532.73 4633.83 3456.27 4919.55 4449.54 4755.37 4090.71 3650.51 5100.46 4007.31 4345.86 4316.44 4068.6 2820.24 4741.32 4506.18 6524.95 3961.68 6121.95 3609.39
RO NT
L2 o Kn 46822 23079.5 13116.4 15394 15544.3 10781.6 12751.8 16328.7 13596.3 9267.04 10303.8 11912.2 7660.32 12440 10188.8 10374.9 8501.79 4078.65 9492.53 10194.4 8497.49 9787.81 8342.76 9336.26 7596.47 6379.82 7325.14 6352.2 6814.49 6403.52 7809.93 4823.08 10741.1 6422.52 6452.36 5791.43 4355.14 5399.01 6866.51 4263.54 5177.04 5159.04 5994.7 4644.63 4521.82 6714.13 4959.52 4397.97 6384.34 3879.52 4411.69 4181.49 4671.03 6217.39 4600.95 5682.1 6022.09
RI PT
sc De E9Q616_MOUSE Protein Ahnak CH60_MOUSE 60 kDa heat shock protein, mitochondrial G3P_MOUSE Glyceraldehyde-3-phosphate dehydrogenase GRP75_MOUSE Stress-70 protein, mitochondrial FABP4_MOUSE Fatty acid-binding protein, adipocyte PGK1_MOUSE Phosphoglycerate kinase 1 PDIA4_MOUSE Protein disulfide-isomerase A4 ACSL1_MOUSE Long-chain-fatty-acid--CoA ligase 1 ATPB_MOUSE ATP synthase subunit beta, mitochondrial HSP7C_MOUSE Heat shock cognate 71 kDa protein MDHM_MOUSE Malate dehydrogenase, mitochondrial GRP78_MOUSE 78 kDa glucose-regulated protein TPIS_MOUSE Triosephosphate isomerase PYC_MOUSE Pyruvate carboxylase, mitochondrial MYH9_MOUSE Myosin-9 TKT_MOUSE Transketolase ENOA_MOUSE Alpha-enolase FABP5_MOUSE Fatty acid-binding protein, epidermal ACON_MOUSE Aconitate hydratase, mitochondrial PDIA1_MOUSE Protein disulfide-isomerase SPTN1_MOUSE Spectrin alpha chain, non-erythrocytic 1 CALR_MOUSE Calreticulin MMSA_MOUSE Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial PDIA3_MOUSE Protein disulfide-isomerase A3 ENPL_MOUSE Endoplasmin ACTB_MOUSE Actin, cytoplasmic 1 MYH10_MOUSE Myosin-10 EF2_MOUSE Elongation factor 2 FUMH_MOUSE Fumarate hydratase, mitochondrial DYHC1_MOUSE Cytoplasmic dynein 1 heavy chain 1 HS90A_MOUSE Heat shock protein HSP 90-alpha IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic PLIN4_MOUSE Perilipin-4 SYEP_MOUSE Bifunctional glutamate/proline--tRNA ligase NUCL_MOUSE Nucleolin DHE3_MOUSE Glutamate dehydrogenase 1, mitochondrial TERA_MOUSE Transitional endoplasmic reticulum ATPase HS90B_MOUSE Heat shock protein HSP 90-beta SERPH_MOUSE Serpin H1 KPYM_MOUSE Pyruvate kinase PKM 1433B_MOUSE 14-3-3 protein beta/alpha FAS_MOUSE Fatty acid synthase ATPA_MOUSE ATP synthase subunit alpha, mitochondrial 3HIDH_MOUSE 3-hydroxyisobutyrate dehydrogenase, mitochondrial ATP5H_MOUSE ATP synthase subunit d, mitochondrial LDHA_MOUSE L-lactate dehydrogenase A chain ALDH2_MOUSE Aldehyde dehydrogenase, mitochondrial Q3U2G2_MOUSE Heat shock 70 kDa protein 4 VINC_MOUSE Vinculin A6ZI44_MOUSE Fructose-bisphosphate aldolase TLN1_MOUSE Talin-1 KAD2_MOUSE Adenylate kinase 2, mitochondrial TPR_MOUSE Nucleoprotein TPR EF1A1_MOUSE Elongation factor 1-alpha 1 VIGLN_MOUSE Vigilin CH10_MOUSE 10 kDa heat shock protein, mitochondrial SPTB2_MOUSE Spectrin beta chain, non-erythrocytic 1
e id pt
SC
G Ahnak Hspd1 Gapdh Hspa9 Fabp4 Pgk1 Pdia4 Acsl1 Atp5b Hspa8 Mdh2 Hspa5 Tpi1 Pc Myh9 Tkt Eno1 Fabp5 Aco2 P4hb Sptan1 Calr Aldh6a1 Pdia3 Hsp90b1 Actb Myh10 Eef2 Fh Dync1h1 Hsp90aa1 Idh1 Plin4 Eprs Ncl Glud1 Vcp Hsp90ab1 Serpinh1 Pkm Ywhab Fasn Atp5a1 Hibadh Atp5h Ldha Aldh2 Hspa4 Vcl Aldoa Tln1 Ak2 Tpr Eef1a1 Hdlbp Hspe1 Sptbn1
tio rip
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e
l
TE D
en
bo
EP
n ei ot Pr tr|E9Q616|E9Q616_MOUSE sp|P63038|CH60_MOUSE sp|P16858|G3P_MOUSE sp|P38647|GRP75_MOUSE sp|P04117|FABP4_MOUSE sp|P09411|PGK1_MOUSE sp|P08003|PDIA4_MOUSE sp|P41216|ACSL1_MOUSE sp|P56480|ATPB_MOUSE sp|P63017|HSP7C_MOUSE sp|P08249|MDHM_MOUSE sp|P20029|GRP78_MOUSE sp|P17751|TPIS_MOUSE sp|Q05920|PYC_MOUSE sp|Q8VDD5|MYH9_MOUSE sp|P40142|TKT_MOUSE sp|P17182|ENOA_MOUSE sp|Q05816|FABP5_MOUSE sp|Q99KI0|ACON_MOUSE sp|P09103|PDIA1_MOUSE sp|P16546|SPTN1_MOUSE sp|P14211|CALR_MOUSE sp|Q9EQ20|MMSA_MOUSE sp|P27773|PDIA3_MOUSE sp|P08113|ENPL_MOUSE sp|P60710|ACTB_MOUSE sp|Q61879|MYH10_MOUSE sp|P58252|EF2_MOUSE sp|P97807|FUMH_MOUSE sp|Q9JHU4|DYHC1_MOUSE sp|P07901|HS90A_MOUSE sp|O88844|IDHC_MOUSE sp|O88492|PLIN4_MOUSE sp|Q8CGC7|SYEP_MOUSE sp|P09405|NUCL_MOUSE sp|P26443|DHE3_MOUSE sp|Q01853|TERA_MOUSE sp|P11499|HS90B_MOUSE sp|P19324|SERPH_MOUSE sp|P52480|KPYM_MOUSE sp|Q9CQV8|1433B_MOUSE sp|P19096|FAS_MOUSE sp|Q03265|ATPA_MOUSE sp|Q99L13|3HIDH_MOUSE sp|Q9DCX2|ATP5H_MOUSE sp|P06151|LDHA_MOUSE sp|P47738|ALDH2_MOUSE tr|Q3U2G2|Q3U2G2_MOUSE sp|Q64727|VINC_MOUSE tr|A6ZI44|A6ZI44_MOUSE sp|P26039|TLN1_MOUSE sp|Q9WTP6|KAD2_MOUSE sp|F6ZDS4|TPR_MOUSE sp|P10126|EF1A1_MOUSE sp|Q8VDJ3|VIGLN_MOUSE sp|Q64433|CH10_MOUSE sp|Q62261|SPTB2_MOUSE
m Sy
AC C
Id
ck
1 wn do o Kn 40366.8 19009.5 9695.92 13540.2 13396 8199.51 10314.7 13877.9 10204.3 8439.4 8472.97 10398.1 7110.53 9859.08 7664.42 8419.51 7354.13 3608.88 6745.14 8633.95 6682.7 8772.55 7946.9 7477.98 6653.1 6379.82 5685.3 5923.1 5973.96 6845.03 6265.12 3554.9 8312.42 4697.68 6691.33 5674.94 4544.56 4517.3 4866.93 3561.86 4060.61 6605.05 5946.12 3559.26 3343.3 5172.41 4313.82 4466.44 5750.5 3811.5 3353.63 3548 3787.9 8369.58 4176.48 4436.76 4390.29
ck
2 wn do
r ve
O 29382.4 14220.6 21299.5 14407.5 12788.6 26044.5 10376.2 9704.86 7891.6 10315.4 8994.75 10604.2 12237.2 5900.96 15474.8 8897.63 12149.1 13300.5 6977.97 11243.8 7371.56 7833.83 5131.78 6840.56 8362.47 6379.82 6085.78 11586.4 5568.07 7784.97 9334.46 6573.8 4655.88 8754.48 5926.75 5020.99 6402.26 7544.77 4074.6 12419.8 2477.27 7842.94 4565.15 4346.15 2426.67 6436.25 5536 6589.4 5586.56 5376.97 5910.65 5128.39 4197.42 7578.42 3224.65 4573.87 4803.58
e
s re xp
si o
n1 r ve
O 59526.6 26408 16513.5 23857.7 24916.1 27728 14317 11806.4 11100.8 12542.6 12005 12899.8 21618.5 8948.49 8178.31 8871.19 11744 48880.3 10161.9 12554.3 7328.34 13846.2 9421.83 11588.5 6186.6 6379.82 5175.78 8587.55 5531.5 5304.31 5734.48 7992.83 8244.33 5937.63 8725.06 6480.7 7782.03 5376.24 3324.08 8681.19 4517.41 10390.8 4647 10224.3 6222.64 4948.79 9048.01 9198.76 6462.84 6564.73 4693.73 8773.82 5739.39 6046.05 3657.99 10254.6 4411.72
e
s re xp
si o
n2
O /C KD 0.93 0.98 1.14 0.96 0.83 0.97 0.96 1.33 1.01 0.93 1.02 1.08 0.96 1.26 1.62 1.00 0.94 1.03 1.12 0.96 1.08 0.99 1.01 1.04 1.04 1.00 1.24 1.22 1.12 1.21 0.98 1.08 1.70 1.28 1.10 0.96 0.80 0.98 1.20 1.16 0.92 1.50 1.20 0.96 1.10 1.14 1.03 0.98 1.37 0.99 1.27 0.80 0.95 1.31 1.04 0.86 1.33
N
0.95 0.94 1.89 1.26 1.09 2.76 1.03 0.95 0.81 1.20 1.14 1.14 2.20 0.84 2.15 0.94 1.42 8.32 1.19 1.22 1.05 1.15 0.91 1.14 1.07 1.00 1.08 2.01 0.98 1.20 1.05 1.88 1.15 1.69 1.22 0.97 1.27 1.27 0.76 3.13 0.69 2.32 0.92 1.70 1.21 1.10 1.61 1.75 1.36 1.54 1.73 1.44 1.11 1.22 0.82 1.26 1.18
ACCEPTED MANUSCRIPT
3130.47 3887.51 3958.73 2980.36 3754.28 3292.39 5312.56 3303.76 4129.63 2585.93 2378.68 2948.17 4207.31 3881.11 3423.7 3090.97 3706.83 3263.24 4059.93 5138.91 3126 3331.94 2997.83 3588.63 4129.32 5146.5 2947.18 3354.02 4480.28 4699.02 2346.57 3495.6 4396.8 2661.74 2505.39 3575.29 4236.17 1508.17 3525.5 2497.44 3004.13 2726.37 3182.15 2508.7 3485.25 2909.5 1947.65 3296.51 2980.45 2644.85 3232.6 2210.02 2642.17 2512.65 3270.6 2346.98 3068.24 3470.04 2640.72 2722.63 2678.53 3010.02
4383.23 4661.37 4592.61 4155.5 3438.72 5105.64 7934.96 4458.91 4119.78 4199.11 4869.62 3618.5 6197.89 3525.53 4833.44 4202.47 3566.27 4859.57 5189.01 4643.88 4060.77 3554.91 3624.38 4532.07 3501.54 5347.51 5994.9 4218.05 4174.28 4132.67 3667.95 5100.35 4499.52 7007.32 4106.99 3885.05 4135.74 2417.78 2987.23 3360.97 3619.05 4404.29 3349.17 3107.89 3613.98 3596.39 3525.49 5224.53 3742.19 3302.27 4437.17 3271.24 4101.67 3600.44 3934.99 3182.48 2581.03 5243.66 3381.56 4393.59 3990.98 5365.34
TE D
M AN U
SC
RI PT
E9Q6R7_MOUSE Protein Utrn 81 3781.35 Q8R5L1_MOUSE Complement component 1 Q subcomponent-binding protein, mitochondrial 81 3745.98 CALU_MOUSE Calumenin 80 3766.41 UBA1_MOUSE Ubiquitin-like modifier-activating enzyme 1 79 3847.63 ECHM_MOUSE Enoyl-CoA hydratase, mitochondrial 79 4261.46 ECHA_MOUSE Trifunctional enzyme subunit alpha, mitochondrial 77 2988.34 CISY_MOUSE Citrate synthase, mitochondrial 77 5917.6 TRAP1_MOUSE Heat shock protein 75 kDa, mitochondrial 77 4312.22 HNRPQ_MOUSE Heterogeneous nuclear ribonucleoprotein Q 77 4157.09 LETM1_MOUSE LETM1 and EF-hand domain-containing protein 1, mitochondrial 76 3105.96 FLNA_MOUSE Filamin-A 75 2487.89 1433Z_MOUSE 14-3-3 protein zeta/delta 75 3152.18 CYC_MOUSE Cytochrome c, somatic 74 3582.68 PGAM1_MOUSE Phosphoglycerate mutase 1 74 3483.42 OPA1_MOUSE Dynamin-like 120 kDa protein, mitochondrial 74 4497.12 GPDA_MOUSE Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic 73 2953.37 CBR1_MOUSE Carbonyl reductase [NADPH] 1 73 4063.44 G6PI_MOUSE Glucose-6-phosphate isomerase 71 3578 SCOT1_MOUSE Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 71 4634.64 STIP1_MOUSE Stress-induced-phosphoprotein 1 71 3827.32 ACADL_MOUSE Long-chain specific acyl-CoA dehydrogenase, mitochondrial 71 4258.71 1433G_MOUSE 14-3-3 protein gamma 70 3505.48 TCPQ_MOUSE T-complex protein 1 subunit theta 69 3201.15 ACADM_MOUSE Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 69 4862.92 IPYR_MOUSE Inorganic pyrophosphatase 69 3806.85 E9PZ00_MOUSE Sulfated glycoprotein 1 68 5065.96 E9PWQ3_MOUSE Protein Col6a3 67 3880.57 DECR_MOUSE 2,4-dienoyl-CoA reductase, mitochondrial 67 3866.6 ROA2_MOUSE Heterogeneous nuclear ribonucleoproteins A2/B1 67 4860.72 CACP_MOUSE Carnitine O-acetyltransferase 66 5310.83 UGPA_MOUSE UTP--glucose-1-phosphate uridylyltransferase 65 2728.95 EHD2_MOUSE EH domain-containing protein 2 65 4075.57 PRDX1_MOUSE Peroxiredoxin-1 64 4639.53 CO3A1_MOUSE Collagen alpha-1(III) chain 63 5265.8 MAOX_MOUSE NADP-dependent malic enzyme 62 2923.8 MAP4_MOUSE Microtubule-associated protein 4 62 3096.13 RLA2_MOUSE 60S acidic ribosomal protein P2 62 3380.95 FLNB_MOUSE Filamin-B 61 1626.39 CLH1_MOUSE Clathrin heavy chain 1 61 2434.62 VIME_MOUSE Vimentin 61 2588.09 ACBP_MOUSE Acyl-CoA-binding protein 61 2881.76 DNM1L_MOUSE Dynamin-1-like protein 60 3334.29 LEG1_MOUSE Galectin-1 60 2687.78 IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial 60 2820.87 GELS_MOUSE Isoform 2 of Gelsolin 60 3564.3 EFTU_MOUSE Elongation factor Tu, mitochondrial 60 3733.96 PLEC_MOUSE Plectin 59 2384.22 DLDH_MOUSE Dihydrolipoyl dehydrogenase, mitochondrial 59 3638.91 VP13C_MOUSE Vacuolar protein sorting-associated protein 13C 59 3086.22 EF1G_MOUSE Elongation factor 1-gamma 59 2720.5 CATD_MOUSE Cathepsin D 59 3647.15 RRBP1_MOUSE Ribosome-binding protein 1 58 2242.11 MDHC_MOUSE Malate dehydrogenase, cytoplasmic 58 2806 IQGA1_MOUSE Ras GTPase-activating-like protein IQGAP1 58 2856.02 CATA_MOUSE Catalase 58 3572.1 MVP_MOUSE Major vault protein 58 2944.91 ANXA8_MOUSE Annexin A8 58 2957.26 ECHB_MOUSE Trifunctional enzyme subunit beta, mitochondrial 57 2867.45 ODP2_MOUSE Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, 57 mitochondrial 3133.1 MUTA_MOUSE Methylmalonyl-CoA mutase, mitochondrial 56 3482.67 RL5_MOUSE 60S ribosomal protein L5 56 3097.83 BCAT2_MOUSE Branched-chain-amino-acid aminotransferase, mitochondrial 55 3586.44
EP
Utrn C1qbp Calu Uba1 Echs1 Hadha Cs Trap1 Syncrip Letm1 Flna Ywhaz Cycs Pgam1 Opa1 Gpd1 Cbr1 Gpi Oxct1 Stip1 Acadl Ywhag Cct8 Acadm Ppa1 Psap Col6a3 Decr1 Hnrnpa2b1 Crat Ugp2 Ehd2 Prdx1 Col3a1 Me1 Map4 Rplp2 Flnb Cltc Vim Dbi Dnm1l Lgals1 Idh2 Gsn Tufm Plec Dld Vps13c Eef1g Ctsd Rrbp1 Mdh1 Iqgap1 Cat Mvp Anxa8 Hadhb Dlat Mut Rpl5 Bcat2
AC C
tr|E9Q6R7|E9Q6R7_MOUSE tr|Q8R5L1|Q8R5L1_MOUSE sp|O35887|CALU_MOUSE sp|Q02053|UBA1_MOUSE sp|Q8BH95|ECHM_MOUSE sp|Q8BMS1|ECHA_MOUSE sp|Q9CZU6|CISY_MOUSE sp|Q9CQN1|TRAP1_MOUSE sp|Q7TMK9|HNRPQ_MOUSE sp|Q9Z2I0|LETM1_MOUSE sp|Q8BTM8|FLNA_MOUSE sp|P63101|1433Z_MOUSE sp|P62897|CYC_MOUSE sp|Q9DBJ1|PGAM1_MOUSE sp|P58281|OPA1_MOUSE sp|P13707|GPDA_MOUSE sp|P48758|CBR1_MOUSE sp|P06745|G6PI_MOUSE sp|Q9D0K2|SCOT1_MOUSE sp|Q60864|STIP1_MOUSE sp|P51174|ACADL_MOUSE sp|P61982|1433G_MOUSE sp|P42932|TCPQ_MOUSE sp|P45952|ACADM_MOUSE sp|Q9D819|IPYR_MOUSE tr|E9PZ00|E9PZ00_MOUSE tr|E9PWQ3|E9PWQ3_MOUSE sp|Q9CQ62|DECR_MOUSE sp|O88569|ROA2_MOUSE sp|P47934|CACP_MOUSE sp|Q91ZJ5|UGPA_MOUSE sp|Q8BH64|EHD2_MOUSE sp|P35700|PRDX1_MOUSE sp|P08121|CO3A1_MOUSE sp|P06801|MAOX_MOUSE sp|P27546|MAP4_MOUSE sp|P99027|RLA2_MOUSE sp|Q80X90|FLNB_MOUSE sp|Q68FD5|CLH1_MOUSE sp|P20152|VIME_MOUSE sp|P31786|ACBP_MOUSE sp|Q8K1M6|DNM1L_MOUSE sp|P16045|LEG1_MOUSE sp|P54071|IDHP_MOUSE sp|P13020-2|GELS_MOUSE sp|Q8BFR5|EFTU_MOUSE sp|Q9QXS1|PLEC_MOUSE sp|O08749|DLDH_MOUSE sp|Q8BX70|VP13C_MOUSE sp|Q9D8N0|EF1G_MOUSE sp|P18242|CATD_MOUSE sp|Q99PL5|RRBP1_MOUSE sp|P14152|MDHC_MOUSE sp|Q9JKF1|IQGA1_MOUSE sp|P24270|CATA_MOUSE sp|Q9EQK5|MVP_MOUSE sp|O35640|ANXA8_MOUSE sp|Q99JY0|ECHB_MOUSE sp|Q8BMF4|ODP2_MOUSE sp|P16332|MUTA_MOUSE sp|P47962|RL5_MOUSE sp|O35855|BCAT2_MOUSE
3068.53 3524.62 3278.04 3299.21 3492.17 3626.48 5845.3 3710.41 3556.92 3158.52 3765.83 2905.66 3353.95 4463.9 3465.6 4096.4 2521.87 3453.13 4842.3 5557.17 3270.84 2665.53 3073.39 3901.89 2701.25 4653.84 4240.24 3187.41 3644.31 4522.04 2801.92 4119.46 3859.82 3024.41 3830.9 3442.32 3619.73 1876.17 4479.59 2470.95 2922.27 3189.11 3260.5 2263.41 3268.96 2805.13 2419.71 4166.84 4041.49 3355.84 3896.27 3044.62 3457.8 2792.64 3431.78 2479.84 2573.38 3477.8 2750.89 3661.88 3006.08 4211.7
3637.71 3031.18 2690.65 4560.04 3096.97 4742.21 5437.83 2223.34 3008.24 2785.35 4710.34 4604.36 3903.45 5077.21 3147.18 3787.23 5762.43 5623.71 3972.44 5858.58 2498.42 3129.55 4733.87 1830.64 6087.36 3213.21 2092.82 3821.04 2761.01 3147.62 4066.37 3024.49 4533.38 1124.7 2581.99 2129.68 2905.11 5014.93 5542.5 2484.7 1380.17 3959.47 2510.09 4908.19 2658.33 2416.89 5533.21 2784.01 2758.03 4635.22 1750.59 2770.53 2242.72 4552.15 2530.63 2063.28 4091.11 2682.43 2188.69 1736 3344.51 2878.33
3968.32 6450.02 5015.24 3631.08 5218.82 9974.06 4847.29 3227.36 4921.16 3978.21 4875.35 5117.46 5773.29 5663.91 3384.33 5877.37 8494.19 3135.5 5322.21 8526.45 3990.54 4474.41 3250.9 3739.82 14545 7347.1 1826.31 4999.14 6564.14 4246.57 3537.3 4034.91 10678.3 1225.07 3088.07 2371 6405.32 3194.32 4197.94 7687.18 4788.59 3263.45 6531.33 4726.43 4034.89 5199.73 4186.88 3470.84 2607.23 3059.87 2999.61 5081.21 2631.43 2514.51 4146.46 2656.46 3072.68 6139.47 3246.54 2463.43 2406.49 4218.58
1.08 1.07 1.02 1.09 0.86 1.39 1.23 1.07 0.93 1.29 1.77 1.07 1.23 1.08 1.05 1.37 0.78 1.22 1.15 1.14 0.99 0.91 1.08 1.00 0.78 0.98 1.50 1.03 0.84 0.86 1.27 1.22 0.93 1.27 1.46 1.10 1.02 1.37 1.25 1.15 1.11 1.25 1.13 1.01 0.98 0.96 1.37 1.35 1.28 1.24 1.21 1.42 1.39 1.19 1.08 1.07 0.86 1.38 1.06 1.30 1.21 1.45
1.10 1.24 1.00 1.20 1.04 2.34 0.92 0.72 0.96 1.19 1.97 1.59 1.24 1.46 0.82 1.60 1.83 1.28 1.07 1.60 0.88 1.11 1.29 0.66 2.60 1.03 0.57 1.22 1.00 0.74 1.50 0.93 1.68 0.30 1.04 0.67 1.22 2.62 1.63 2.00 1.05 1.19 1.54 1.81 0.95 1.15 2.24 0.90 0.88 1.43 0.69 1.76 0.89 1.32 0.98 0.89 1.19 1.39 0.94 0.68 1.00 1.08
ACCEPTED MANUSCRIPT
2820.64 2674.86 2404.85 3987.21 2895.93 3396.89 3715.38 3710.16 2416.11 2716.69 4249.6 1583.94 1833.78 2472.21 2248.42 2459.53 1921.33 2583.85 2304.38 2093.03 2878.77 2896.84 2519.21 2384.85 3042.17 2261.48 2737.34 2522.97 3835.72 2478.09 2476.75 2552.61 2172.67 2540.85 2491.28 2447.27 2893.12 4530.04 3108.68 2470.15 2661 1644.35 1647.54 2234.47 2651.04 3074.53 2413.9 2449.7 2141.35 2776.37 2817.14 2180.86 2329.65 1490.88 2698.73 2813.23 1680.37 1701.81 1570.69 1677.73 3045.94 3497.85
3566.38 4512.6 3233.69 3290.35 3304.6 3761.56 3785.22 2807.27 4099.55 2767.32 3228.98 2032.18 2497.8 2806.14 2910.66 3138.7 3424.24 3082.7 2352.26 3659.91 3358.87 3331.88 2521.25 2552.24 3382.01 3269.71 3595.63 2862.24 3667.45 3193.11 3104.84 3155.17 2899.05 2859.28 2143.36 2273.81 3416.9 3158.65 4059.12 2992.23 3217.73 2373.23 2576.27 2230.58 3308.3 3512.66 1899.53 3084.99 2448.89 3264.87 3950.13 2540.43 2523.02 1904.89 2786.03 2415.03 2473.67 2305.56 2178.71 2109.69 3353.57 3327.08
TE D
M AN U
SC
RI PT
ATPG_MOUSE ATP synthase subunit gamma, mitochondrial 55 3250.76 ODB2_MOUSE Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase 55 complex, mitochondrial 3420.1 E9PVZ8_MOUSE Protein Golgb1 55 2514.73 COF1_MOUSE Cofilin-1 55 2723.29 TCPB_MOUSE T-complex protein 1 subunit beta 55 3252.38 NCPR_MOUSE NADPH--cytochrome P450 reductase 55 3823.56 PTRF_MOUSE Polymerase I and transcript release factor 55 3378.93 PABP1_MOUSE Polyadenylate-binding protein 1 55 3050.09 PGM1_MOUSE Phosphoglucomutase-1 54 2756.37 RS3A_MOUSE 40S ribosomal protein S3a 54 2957.49 ANXA6_MOUSE Annexin A6 54 4496.37 THIM_MOUSE 3-ketoacyl-CoA thiolase, mitochondrial 53 1463.79 AMPL_MOUSE Cytosol aminopeptidase 53 1850.57 DDB1_MOUSE DNA damage-binding protein 1 53 2586.06 HYOU1_MOUSE Hypoxia up-regulated protein 1 53 2468.59 ANXA1_MOUSE Annexin A1 53 2699.53 NAMPT_MOUSE Nicotinamide phosphoribosyltransferase 52 2160.29 TCPE_MOUSE T-complex protein 1 subunit epsilon 52 2827.78 PRS6A_MOUSE 26S protease regulatory subunit 6A 52 2324.12 AIFM1_MOUSE Apoptosis-inducing factor 1, mitochondrial 51 2517.75 RS27A_MOUSE Ubiquitin-40S ribosomal protein S27a 51 2890.9 SDHB_MOUSE Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 51 2976.94 ETFA_MOUSE Electron transfer flavoprotein subunit alpha, mitochondrial 51 2635.41 HNRPU_MOUSE Heterogeneous nuclear ribonucleoprotein U 51 3014.06 CO3_MOUSE Complement C3 50 2596.18 IMMT_MOUSE Mitochondrial inner membrane protein 50 2885.76 ACOC_MOUSE Cytoplasmic aconitate hydratase 50 3114.19 PPIA_MOUSE Peptidyl-prolyl cis-trans isomerase A 50 2306.7 PRDX5_MOUSE Peroxiredoxin-5, mitochondrial 50 3814.52 ACACA_MOUSE Acetyl-CoA carboxylase 1 49 2309.28 SYYC_MOUSE Tyrosine--tRNA ligase, cytoplasmic 49 2868.65 SDHA_MOUSE Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 49 3138.93 LONM_MOUSE Lon protease homolog, mitochondrial 49 2583.14 LAMB1_MOUSE Laminin subunit beta-1 49 2639.15 EF1B_MOUSE Elongation factor 1-beta 49 2083.17 TBA1B_MOUSE Tubulin alpha-1B chain 49 2569.09 SAHH_MOUSE Adenosylhomocysteinase 49 4016.74 GRPE1_MOUSE GrpE protein homolog 1, mitochondrial 49 2594.88 AL1A7_MOUSE Aldehyde dehydrogenase, cytosolic 1 48 3547.33 NLTP_MOUSE Non-specific lipid-transfer protein 47 2285.01 NDUS1_MOUSE NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial 47 3613.59 MOES_MOUSE Moesin 46 1652.43 PSA_MOUSE Puromycin-sensitive aminopeptidase 46 2094.89 HSP72_MOUSE Heat shock-related 70 kDa protein 2 46 1999.23 ALDR_MOUSE Aldose reductase 46 3253.47 CPT2_MOUSE Carnitine O-palmitoyltransferase 2, mitochondrial 46 3534.22 FLNC_MOUSE Filamin-C 46 2359.76 SYIC_MOUSE Isoleucine--tRNA ligase, cytoplasmic 45 2435.12 CAND1_MOUSE Cullin-associated NEDD8-dissociated protein 1 45 1879.88 RLA0_MOUSE 60S acidic ribosomal protein P0 45 2598.47 ETFB_MOUSE Electron transfer flavoprotein subunit beta 45 2880.53 E9PZF0_MOUSE Nucleoside diphosphate kinase 45 2243.55 GDIB_MOUSE Rab GDP dissociation inhibitor beta 45 2711.23 VDAC1_MOUSE Voltage-dependent anion-selective channel protein 1 45 2073.43 ODPX_MOUSE Pyruvate dehydrogenase protein X component, mitochondrial 45 2853.32 GDIA_MOUSE Rab GDP dissociation inhibitor alpha 45 3399.97 LPPRC_MOUSE Leucine-rich PPR motif-containing protein, mitochondrial 44 1312.82 SUCB1_MOUSE Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial 44 1816 SYAC_MOUSE Alanine--tRNA ligase, cytoplasmic 44 1779.26 TCPA_MOUSE T-complex protein 1 subunit alpha 44 2033.34 IVD_MOUSE Isovaleryl-CoA dehydrogenase, mitochondrial 44 3536.5 RL17_MOUSE 60S ribosomal protein L17 44 3280.21
EP
Atp5c1 Dbt Golgb1 Cfl1 Cct2 Por Ptrf Pabpc1 Pgm1 Rps3a Anxa6 Acaa2 Lap3 Ddb1 Hyou1 Anxa1 Nampt Cct5 Psmc3 Aifm1 Rps27a Sdhb Etfa Hnrnpu C3 Immt Aco1 Ppia Prdx5 Acaca Yars Sdha Lonp1 Lamb1 Eef1b Tuba1b Ahcy Grpel1 Aldh1a7 Scp2 Ndufs1 Msn Npepps Hspa2 Akr1b1 Cpt2 Flnc Iars Cand1 Rplp0 Etfb Gm20390 Gdi2 Vdac1 Pdhx Gdi1 Lrpprc Sucla2 Aars Tcp1 Ivd Rpl17
AC C
sp|Q91VR2|ATPG_MOUSE sp|P53395|ODB2_MOUSE tr|E9PVZ8|E9PVZ8_MOUSE sp|P18760|COF1_MOUSE sp|P80314|TCPB_MOUSE sp|P37040|NCPR_MOUSE sp|O54724|PTRF_MOUSE sp|P29341|PABP1_MOUSE sp|Q9D0F9|PGM1_MOUSE sp|P97351|RS3A_MOUSE sp|P14824|ANXA6_MOUSE sp|Q8BWT1|THIM_MOUSE sp|Q9CPY7|AMPL_MOUSE sp|Q3U1J4|DDB1_MOUSE sp|Q9JKR6|HYOU1_MOUSE sp|P10107|ANXA1_MOUSE sp|Q99KQ4|NAMPT_MOUSE sp|P80316|TCPE_MOUSE sp|O88685|PRS6A_MOUSE sp|Q9Z0X1|AIFM1_MOUSE sp|P62983|RS27A_MOUSE sp|Q9CQA3|SDHB_MOUSE sp|Q99LC5|ETFA_MOUSE sp|Q8VEK3|HNRPU_MOUSE sp|P01027|CO3_MOUSE sp|Q8CAQ8|IMMT_MOUSE sp|P28271|ACOC_MOUSE sp|P17742|PPIA_MOUSE sp|P99029|PRDX5_MOUSE sp|Q5SWU9|ACACA_MOUSE sp|Q91WQ3|SYYC_MOUSE sp|Q8K2B3|SDHA_MOUSE sp|Q8CGK3|LONM_MOUSE sp|P02469|LAMB1_MOUSE sp|O70251|EF1B_MOUSE sp|P05213|TBA1B_MOUSE sp|P50247|SAHH_MOUSE sp|Q99LP6|GRPE1_MOUSE sp|O35945|AL1A7_MOUSE sp|P32020|NLTP_MOUSE sp|Q91VD9|NDUS1_MOUSE sp|P26041|MOES_MOUSE sp|Q11011|PSA_MOUSE sp|P17156|HSP72_MOUSE sp|P45376|ALDR_MOUSE sp|P52825|CPT2_MOUSE sp|Q8VHX6|FLNC_MOUSE sp|Q8BU30|SYIC_MOUSE sp|Q6ZQ38|CAND1_MOUSE sp|P14869|RLA0_MOUSE sp|Q9DCW4|ETFB_MOUSE tr|E9PZF0|E9PZF0_MOUSE sp|Q61598|GDIB_MOUSE sp|Q60932|VDAC1_MOUSE sp|Q8BKZ9|ODPX_MOUSE sp|P50396|GDIA_MOUSE sp|Q6PB66|LPPRC_MOUSE sp|Q9Z2I9|SUCB1_MOUSE sp|Q8BGQ7|SYAC_MOUSE sp|P11983|TCPA_MOUSE sp|Q9JHI5|IVD_MOUSE sp|Q9CPR4|RL17_MOUSE
4299.81 3123.87 2408.35 3525.94 2713.72 3265.73 2933.15 3115.71 2894.94 2646.01 2551.98 1655.64 1859.35 2809.12 2239.62 2198.63 2534.75 2565.5 1973.98 2709.35 2822.46 2658.51 2470.3 2190.07 3740.24 2682.42 3131.55 2369.02 2973.51 3696.8 2659.65 2783.81 1996.71 2334.23 2432.31 2682.43 3150.76 3054.18 3710.1 2739.47 2611.08 1801.97 1878.49 2312.4 2715.78 2914.27 1558.77 3007.31 2560.38 2977.55 2509.76 2155.91 2676.84 1440.31 2332.33 2355.99 2320.85 2134.59 1982.88 1783.94 3228.43 3007.72
2502.9 2484.96 2914.93 5219.73 3481.87 4127.84 2142.68 2806.24 3006.87 3795.85 4875.53 4602.65 3263.64 2572.62 2520.33 4017.7 3726.28 3806.12 2389.87 2390.22 3596.64 2593.47 2206.72 4370.67 1288.32 5561.55 4006.87 1861.24 2878.07 2049.61 3952.23 2948.35 2587.09 1739.72 2755.98 4806.38 4127.16 3574.17 3575.11 4370.99 2869.94 2297.82 2222 2360.74 3362.47 1654.5 5107.08 4316.95 4463.7 3599.33 3256.69 2279.54 2772.33 7070.54 1591.12 2818.1 3341.6 3225.96 1713.16 3565.49 2647.54 2620.44
2697.45 3440.13 4527 9752.23 3086.21 5128.46 4174.71 5030.87 2106.04 5233.42 2671.4 8486.3 3690.83 2089.58 3247.84 450.645 3462.46 3653.91 4109.42 2005.4 7863.39 3823.7 4770.68 3225.66 2478.61 4369.94 2912.35 4141.88 5658.26 2605.13 3087.93 2681.99 3081.28 2413.24 6916.9 4977.27 3643.42 6133.17 3824.48 6331.14 3556.13 1752.91 1573.07 3223.08 4694.41 2715.26 4756.41 2753.79 2736.44 3387.17 6435.75 3141.46 2238.29 2027.09 3774.12 2427.84 3511.43 5129.33 2314.65 2629.59 3905.92 5216.91
1.30 1.25 1.15 1.02 0.98 0.97 0.95 0.88 1.35 0.95 0.66 1.21 1.18 1.11 1.09 1.03 1.46 1.04 0.93 1.38 1.07 1.02 0.97 0.88 1.26 1.16 1.15 1.08 0.87 1.44 1.08 1.04 1.03 1.00 1.00 0.99 0.95 0.87 1.17 1.21 0.93 1.27 1.19 1.07 1.02 0.97 0.72 1.25 1.25 1.16 1.13 1.06 1.03 0.94 0.92 0.77 1.60 1.26 1.24 1.05 1.00 0.93
0.86 0.97 1.51 2.23 1.07 1.28 0.89 1.16 0.99 1.59 0.86 4.29 1.89 0.92 1.22 0.87 1.76 1.38 1.40 0.95 1.99 1.09 1.35 1.41 0.67 1.93 1.18 1.24 1.12 0.97 1.32 0.99 1.19 0.80 2.11 1.95 1.12 1.36 1.11 2.25 1.02 1.23 1.01 1.32 1.36 0.66 2.07 1.45 1.79 1.30 1.70 1.23 0.99 2.55 0.97 0.84 2.29 2.38 1.20 1.67 1.00 1.16
ACCEPTED MANUSCRIPT
2415.73 1395.44 2990.06 1659.43 1634.6 1711.29 2018.69 1816.15 2824.65 2487.01 2115.29 2681.77 1503.07 2159.22 1975.03 1582.24 2016.5 2098.7 2577.08 2280.47 2480.89 2318.69 3335.4 1769.63 1580.2 1630.4 2114.52 2388.02 2039.35 2587.09 1477.83 1679.63 1297.32 1884.2 1873.74 2155.58 2727.43 1652.35 1643.34 1680.18 1999.95 2630.98 1666.19 1279.04 1275.67 2575.82 1587.3 2502.47 2199.34 2184.61 1823.64 1833.51 1414.34 2188.24 2081.95 2286.35 1552.99 1962.12 1487.34 1682.7 2860.35 1886.27
2145.55 2404.08 4218.63 2207.07 2210.05 2779.67 2733.78 2515.52 3045.44 2309.28 2203.28 2421.7 2495.95 3047.38 2284.83 2041.23 2402.93 2591.48 3002.66 2866.24 2516.23 2284.43 3136.91 2236.27 2275.36 2389.59 2302.82 2611.07 2198.48 2654.46 1825.12 2009.88 1544.33 1695.14 2075.95 2091.77 3472.79 2407.07 2261.72 2495.75 2533.46 2753.13 1802.28 1252.33 1255.69 2410.88 2388.81 3709.08 2837.28 3026.65 2245.76 2187.83 1821.83 2771.98 2254.13 2354.88 1558.98 1926.9 2153.56 2382.81 2400.69 2095.16
TE D
M AN U
SC
RI PT
LMNA_MOUSE Prelamin-A/C 44 2886.24 AL4A1_MOUSE Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 43 1790.84 OLA1_MOUSE Obg-like ATPase 1 43 2619.4 TCPD_MOUSE T-complex protein 1 subunit delta 43 1698.87 TXND5_MOUSE Thioredoxin domain-containing protein 5 43 1569.33 PYGB_MOUSE Glycogen phosphorylase, brain form 43 1987.85 Q3V117_MOUSE ATP-citrate synthase 43 2208.17 ACTN4_MOUSE Alpha-actinin-4 43 2054.38 CALX_MOUSE Calnexin 43 2397.29 PROF1_MOUSE Profilin-1 43 2380.65 SODM_MOUSE Superoxide dismutase [Mn], mitochondrial 43 2306.33 P4HA1_MOUSE Isoform 2 of Prolyl 4-hydroxylase subunit alpha-1 43 2592.52 C1TC_MOUSE C-1-tetrahydrofolate synthase, cytoplasmic 42 1845.46 LDHB_MOUSE L-lactate dehydrogenase B chain 42 2433.05 RL3_MOUSE 60S ribosomal protein L3 42 2042.43 SUCB2_MOUSE Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial 42 1729.94 PDIA6_MOUSE Protein disulfide-isomerase A6 42 2132.37 EIF3A_MOUSE Eukaryotic translation initiation factor 3 subunit A 42 2363.72 SERC_MOUSE Phosphoserine aminotransferase 42 2898.59 ACADS_MOUSE Short-chain specific acyl-CoA dehydrogenase, mitochondrial 42 2846.99 CNDP2_MOUSE Cytosolic non-specific dipeptidase 42 2722.95 DHPR_MOUSE Dihydropteridine reductase 42 2648.73 HMGB1_MOUSE High mobility group protein B1 42 3338.82 AT2A2_MOUSE Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 41 1762.82 HIBCH_MOUSE 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 41 1653.93 ASNS_MOUSE Asparagine synthetase [glutamine-hydrolyzing] 41 1843.32 XDH_MOUSE Xanthine dehydrogenase/oxidase 41 2389.72 TALDO_MOUSE Transaldolase 41 2712.5 ODO2_MOUSE Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase 41 complex, 2261.54 mitochondrial SODC_MOUSE Superoxide dismutase [Cu-Zn] 41 2519.01 MPCP_MOUSE Phosphate carrier protein, mitochondrial 40 1681.97 1433T_MOUSE 14-3-3 protein theta 40 1838.27 IDH3A_MOUSE Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 40 1517.44 NPM_MOUSE Nucleophosmin 40 1619.3 ROA3_MOUSE Heterogeneous nuclear ribonucleoprotein A3 40 1917.87 EEA1_MOUSE Early endosome antigen 1 40 1987.3 BAP31_MOUSE B-cell receptor-associated protein 31 39 2252.49 QCR2_MOUSE Cytochrome b-c1 complex subunit 2, mitochondrial 39 1725.2 SYLC_MOUSE Leucine--tRNA ligase, cytoplasmic 39 1571.94 CD36_MOUSE Platelet glycoprotein 4 39 1871.49 PHB_MOUSE Prohibitin 39 2019.28 HCDH_MOUSE Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 39 2533.08 TBB4B_MOUSE Tubulin beta-4B chain 39 1513.56 PARK7_MOUSE Protein DJ-1 39 1159.38 GCSH_MOUSE Glycine cleavage system H protein, mitochondrial 39 1205.31 1433E_MOUSE 14-3-3 protein epsilon 39 2654.65 AATM_MOUSE Aspartate aminotransferase, mitochondrial 38 1385.2 NNTM_MOUSE NAD(P) transhydrogenase, mitochondrial 38 2788.89 RS2_MOUSE 40S ribosomal protein S2 38 2270.25 RL7_MOUSE 60S ribosomal protein L7 38 2578.81 TCPZ_MOUSE T-complex protein 1 subunit zeta 38 1971.53 MYL6_MOUSE Myosin light polypeptide 6 38 1668.05 IF2P_MOUSE Eukaryotic translation initiation factor 5B 38 1675.43 PDC6I_MOUSE Programmed cell death 6-interacting protein 38 2482.73 SDPR_MOUSE Serum deprivation-response protein 38 1922.53 ROAA_MOUSE Heterogeneous nuclear ribonucleoprotein A/B 38 2039.47 OAT_MOUSE Ornithine aminotransferase, mitochondrial 38 1539.04 PRS4_MOUSE 26S protease regulatory subunit 4 38 2002.73 RPN1_MOUSE Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 37 1768.39 KTN1_MOUSE Isoform 13 of Kinectin 37 1862 TCTP_MOUSE Translationally-controlled tumor protein 37 1766.42 PSD12_MOUSE 26S proteasome non-ATPase regulatory subunit 12 37 1930.24
EP
Lmna Aldh4a1 Ola1 Cct4 Txndc5 Pygb Acly Actn4 Canx Pfn1 Sod2 P4ha1 Mthfd1 Ldhb Rpl3 Suclg2 Pdia6 Eif3a Psat1 Acads Cndp2 Qdpr Hmgb1 Atp2a2 Hibch Asns Xdh Taldo1 Dlst Sod1 Slc25a3 Ywhaq Idh3a Npm1 Hnrnpa3 Eea1 Bcap31 Uqcrc2 Lars Cd36 Phb Hadh Tubb4b Park7 Gcsh Ywhae Got2 Nnt Rps2 Rpl7 Cct6a Myl6 Eif5b Pdcd6ip Sdpr Hnrnpab Oat Psmc1 Rpn1 Ktn1 Tpt1 Psmd12
AC C
sp|P48678|LMNA_MOUSE sp|Q8CHT0|AL4A1_MOUSE sp|Q9CZ30|OLA1_MOUSE sp|P80315|TCPD_MOUSE sp|Q91W90|TXND5_MOUSE sp|Q8CI94|PYGB_MOUSE tr|Q3V117|Q3V117_MOUSE sp|P57780|ACTN4_MOUSE sp|P35564|CALX_MOUSE sp|P62962|PROF1_MOUSE sp|P09671|SODM_MOUSE sp|Q60715-2|P4HA1_MOUSE sp|Q922D8|C1TC_MOUSE sp|P16125|LDHB_MOUSE sp|P27659|RL3_MOUSE sp|Q9Z2I8|SUCB2_MOUSE sp|Q922R8|PDIA6_MOUSE sp|P23116|EIF3A_MOUSE sp|Q99K85|SERC_MOUSE sp|Q07417|ACADS_MOUSE sp|Q9D1A2|CNDP2_MOUSE sp|Q8BVI4|DHPR_MOUSE sp|P63158|HMGB1_MOUSE sp|O55143|AT2A2_MOUSE sp|Q8QZS1|HIBCH_MOUSE sp|Q61024|ASNS_MOUSE sp|Q00519|XDH_MOUSE sp|Q93092|TALDO_MOUSE sp|Q9D2G2|ODO2_MOUSE sp|P08228|SODC_MOUSE sp|Q8VEM8|MPCP_MOUSE sp|P68254|1433T_MOUSE sp|Q9D6R2|IDH3A_MOUSE sp|Q61937|NPM_MOUSE sp|Q8BG05|ROA3_MOUSE sp|Q8BL66|EEA1_MOUSE sp|Q61335|BAP31_MOUSE sp|Q9DB77|QCR2_MOUSE sp|Q8BMJ2|SYLC_MOUSE sp|Q08857|CD36_MOUSE sp|P67778|PHB_MOUSE sp|Q61425|HCDH_MOUSE sp|P68372|TBB4B_MOUSE sp|Q99LX0|PARK7_MOUSE sp|Q91WK5|GCSH_MOUSE sp|P62259|1433E_MOUSE sp|P05202|AATM_MOUSE sp|Q61941|NNTM_MOUSE sp|P25444|RS2_MOUSE sp|P14148|RL7_MOUSE sp|P80317|TCPZ_MOUSE sp|Q60605|MYL6_MOUSE sp|Q05D44|IF2P_MOUSE sp|Q9WU78|PDC6I_MOUSE sp|Q63918|SDPR_MOUSE sp|Q99020|ROAA_MOUSE sp|P29758|OAT_MOUSE sp|P62192|PRS4_MOUSE sp|Q91YQ5|RPN1_MOUSE sp|Q61595-13|KTN1_MOUSE sp|P63028|TCTP_MOUSE sp|Q9D8W5|PSD12_MOUSE
1917.7 1867.58 2862.32 2022.89 1761.15 1764.08 2284.25 1879.88 2545.38 2613.67 1918.33 2094.52 1955.38 2722.35 2170.96 1611.94 2124.04 2161.05 2389.81 2107.1 2032.55 1876.98 2198.91 2237.5 1793.81 1866.43 2162.55 2387.12 1742.78 2010.32 2076.16 1654.97 1206.17 1712.92 1600.99 1827.81 4110.2 2059.16 1927.15 1867.16 2310.2 3146.84 1652.7 1190.49 1109.14 2229.92 1757 3195.01 2562.03 2569.3 2140.7 1713.41 1547.02 2152.37 1868.99 2025.74 1417.31 1791.77 1866.27 1904.35 2955.25 2264.81
1982.1 1278.58 3760.85 3716.14 1339.35 2839.28 2251.24 2851.22 2899.72 3551.66 2615.89 2161.25 3862.34 2706.5 2360.25 1776.45 1762.55 2461.31 2781.02 1654.53 1318.03 2336.07 3244.96 3648.75 3245.88 2928.43 2430.26 2590.59 2051.74 1403.19 3288.1 2457.85 2361.03 2592.49 1472.35 2024.49 3181.54 1831.09 4253.72 1606.33 2576.54 2866.94 3665.33 1904.64 1247.05 2882.95 3753.77 2909.23 3323.13 2365.76 2750.31 2009.47 1782.2 2675.33 1227.67 1401.1 1955.76 2047.59 2823.5 2249.57 2441.33 3121.59
2204.8 1626.26 4132.56 2665.68 2389.32 1601.43 2108.32 2195.36 2542.13 5200.51 5039.2 1892.87 3162.23 2219.59 1566.31 3008.54 2312.77 2470.43 1906.03 2472.27 2166.37 2975.43 6042.06 2491.16 4008.44 2419.16 1856.38 2797.45 2855.99 5071.41 2590.02 2998.17 4694.49 4074.98 2804.14 3479.81 2719.21 1430.68 2390.25 1346.46 2537.6 3623.75 4502.87 4056.09 3119.24 3043.92 1696.3 1842.71 2417.31 2139.01 2353.27 4441.03 2088.09 2415.58 2865.52 3869.56 1942.15 2750.45 2062.15 4156.29 5900.63 2174.95
0.77 1.34 1.26 1.26 1.24 1.23 1.19 1.14 1.07 1.01 0.93 0.86 1.33 1.26 1.11 1.10 1.09 1.07 0.98 0.97 0.87 0.84 0.80 1.27 1.26 1.23 0.99 0.98 0.92 0.91 1.23 1.04 0.98 0.97 0.97 0.95 1.52 1.32 1.30 1.23 1.21 1.14 1.09 1.00 0.95 0.89 1.39 1.30 1.21 1.17 1.16 1.11 1.09 1.05 1.03 1.01 0.96 0.94 1.23 1.21 1.16 1.14
0.79 0.91 1.41 1.90 1.16 1.20 1.03 1.30 1.04 1.80 1.73 0.77 2.10 1.07 0.98 1.44 0.98 1.11 0.86 0.80 0.67 1.07 1.39 1.74 2.24 1.54 0.95 1.06 1.14 1.27 1.86 1.55 2.51 1.90 1.13 1.33 1.18 0.97 2.07 0.83 1.27 1.26 2.57 2.44 1.76 1.13 1.83 0.90 1.28 0.95 1.34 1.84 1.25 1.09 1.02 1.22 1.26 1.21 1.50 1.81 1.80 1.39
ACCEPTED MANUSCRIPT
1654.38 1593.05 2739.27 1404.24 2365.51 1794.31 2037.81 1437.71 1952.65 2308.17 2190.74 2095.48 2227 1002.08 1200.09 1623.57 1817.79 1751.53 3399.98 2302.13 1980.05 1702.41 1709.63 1440.02 1436.39 1930.47 2294.6 1464.68 1496.72 2296.06 1631.42 1486.15 1512.59 1079.08 1185.97 1413.52 2014.34 1532.24 1503.51 1531.34 1821.3 1574.88 1716.33 1758.94 2206.13 1560.82 1951.82 1018.07 1261.27 1688.19 1594.44 1699.04 1327.33 1537.87 1795.29 1725.61 1951.18 722.986 1338.65 714.647 1145.54 1634.65
2475.39 2553.82 2970.86 1789.16 2221 1955.11 2086.24 2126.42 2428.05 2265.58 2786.83 2165.42 2113.42 1617.01 1469.01 2016.36 1682.38 1956.99 3059.14 2202.25 1973.32 3188.81 2103.38 1791.9 1822.58 2512.46 2870.44 1732.85 1594.31 1875.98 2506.01 2186.83 2135.26 1494.87 1276.53 1763.06 2665.82 2222.77 1984.4 1813.4 1964.83 1686.49 1571.46 1951.94 2114.54 1810.92 1803.07 1421.66 1585.75 1852.25 1867.98 1798.76 1738.91 1654.84 1711.74 1682.96 1696.49 2612.81 1751.05 852.833 1367.63 1938.53
RI PT
2035.53 2113.13 2596.52 1761.32 2070.48 1628.6 2168.88 1625.45 1983.01 1720.05 2213.13 2268.37 2514.15 1073.47 1248.93 1807.82 1493.07 2207.4 2647.63 2270.23 2205.87 1137.54 1820.32 1227.89 1566.15 2525.77 2702.97 1900.94 1545.85 1903.46 1976.78 1685.08 1693.32 1240.63 1100.96 1418.24 2356.17 2045.47 1972.06 1729.65 2025.73 1706.27 1492.33 2037.22 2045.34 1888.94 1674.27 1271.4 1396.04 1706.01 1653.37 1698.37 1674.13 1529.8 1924 1875.6 2319.42 934.279 1146.53 571.61 1024.5 1486.45
SC
37 37 37 37 37 37 37 36 36 36 36 36 36 35 35 35 35 35 35 35 35 34 34 34 34 34 34 34 34 34 33 33 33 33 33 33 33 33 33 33 33 33 33 33 33 33 33 32 32 32 32 32 32 32 32 32 32 31 31 31 31 31
M AN U
TE D
EHD1_MOUSE EH domain-containing protein 1 ACADV_MOUSE Very long-chain specific acyl-CoA dehydrogenase, mitochondrial PRDX6_MOUSE Peroxiredoxin-6 AL9A1_MOUSE 4-trimethylaminobutyraldehyde dehydrogenase DDX3X_MOUSE ATP-dependent RNA helicase DDX3X GLU2B_MOUSE Isoform 2 of Glucosidase 2 subunit beta ODPB_MOUSE Pyruvate dehydrogenase E1 component subunit beta, mitochondrial B2L13_MOUSE Bcl-2-like protein 13 FPPS_MOUSE Farnesyl pyrophosphate synthase HXK2_MOUSE Hexokinase-2 Q91VA7_MOUSE Isocitrate dehydrogenase 3 (NAD+) beta SF3A1_MOUSE Splicing factor 3A subunit 1 RL8_MOUSE 60S ribosomal protein L8 PLIN1_MOUSE Perilipin-1 TCPH_MOUSE T-complex protein 1 subunit eta 6PGD_MOUSE 6-phosphogluconate dehydrogenase, decarboxylating HNRPK_MOUSE Heterogeneous nuclear ribonucleoprotein K NEDD4_MOUSE E3 ubiquitin-protein ligase NEDD4 PAIRB_MOUSE Plasminogen activator inhibitor 1 RNA-binding protein GLOD4_MOUSE Glyoxalase domain-containing protein 4 HOT_MOUSE Hydroxyacid-oxoacid transhydrogenase, mitochondrial ATPO_MOUSE ATP synthase subunit O, mitochondrial IF4G1_MOUSE Eukaryotic translation initiation factor 4 gamma 1 IF2B_MOUSE Eukaryotic translation initiation factor 2 subunit 2 PSMD3_MOUSE 26S proteasome non-ATPase regulatory subunit 3 ACOT2_MOUSE Acyl-coenzyme A thioesterase 2, mitochondrial ACOT9_MOUSE Acyl-coenzyme A thioesterase 9, mitochondrial PCYOX_MOUSE Prenylcysteine oxidase GSTP1_MOUSE Glutathione S-transferase P 1 HNRPD_MOUSE Heterogeneous nuclear ribonucleoprotein D0 RAB7A_MOUSE Ras-related protein Rab-7a UGGG1_MOUSE UDP-glucose:glycoprotein glucosyltransferase 1 Q8C3V4_MOUSE Signal transducer and activator of transcription DCTN1_MOUSE Dynactin subunit 1 HNRPL_MOUSE Heterogeneous nuclear ribonucleoprotein L ERO1A_MOUSE ERO1-like protein alpha TIM44_MOUSE Mitochondrial import inner membrane translocase subunit TIM44 PREP_MOUSE Presequence protease, mitochondrial GPDM_MOUSE Glycerol-3-phosphate dehydrogenase, mitochondrial PRS7_MOUSE 26S protease regulatory subunit 7 RL7A_MOUSE 60S ribosomal protein L7a PUR2_MOUSE Trifunctional purine biosynthetic protein adenosine-3 FKBP9_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP9 IF4A1_MOUSE Eukaryotic initiation factor 4A-I IPYR2_MOUSE Inorganic pyrophosphatase 2, mitochondrial KAP3_MOUSE cAMP-dependent protein kinase type II-beta regulatory subunit FUBP2_MOUSE Far upstream element-binding protein 2 HNRPM_MOUSE Isoform 2 of Heterogeneous nuclear ribonucleoprotein M MYO1C_MOUSE Unconventional myosin-Ic SBP1_MOUSE Selenium-binding protein 1 RTCB_MOUSE tRNA-splicing ligase RtcB homolog RS17_MOUSE 40S ribosomal protein S17 G6PD1_MOUSE Glucose-6-phosphate 1-dehydrogenase X RS15_MOUSE 40S ribosomal protein S15 RL4_MOUSE 60S ribosomal protein L4 PA2G4_MOUSE Proliferation-associated protein 2G4 IF4A2_MOUSE Eukaryotic initiation factor 4A-II CES1D_MOUSE Carboxylesterase 1D MARCS_MOUSE Myristoylated alanine-rich C-kinase substrate RBP2_MOUSE E3 SUMO-protein ligase RanBP2 TOM70_MOUSE Mitochondrial import receptor subunit TOM70 COPD_MOUSE Coatomer subunit delta
EP
Ehd1 Acadvl Prdx6 Aldh9a1 Ddx3x Prkcsh Pdhb Bcl2l13 Fdps Hk2 Idh3b Sf3a1 Rpl8 Plin1 Cct7 Pgd Hnrnpk Nedd4 Serbp1 Glod4 Adhfe1 Atp5o Eif4g1 Eif2s2 Psmd3 Acot2 Acot9 Pcyox1 Gstp1 Hnrnpd Rab7a Uggt1 Stat1 Dctn1 Hnrnpl Ero1l Timm44 Pitrm1 Gpd2 Psmc2 Rpl7a Gart Fkbp9 Eif4a1 Ppa2 Prkar2b Khsrp Hnrnpm Myo1c Selenbp1 Rtcb Rps17 G6pdx Rps15 Rpl4 Pa2g4 Eif4a2 Ces1d Marcks Ranbp2 Tomm70a Arcn1
AC C
sp|Q9WVK4|EHD1_MOUSE sp|P50544|ACADV_MOUSE sp|O08709|PRDX6_MOUSE sp|Q9JLJ2|AL9A1_MOUSE sp|Q62167|DDX3X_MOUSE sp|O08795-2|GLU2B_MOUSE sp|Q9D051|ODPB_MOUSE sp|P59017|B2L13_MOUSE sp|Q920E5|FPPS_MOUSE sp|O08528|HXK2_MOUSE tr|Q91VA7|Q91VA7_MOUSE sp|Q8K4Z5|SF3A1_MOUSE sp|P62918|RL8_MOUSE sp|Q8CGN5|PLIN1_MOUSE sp|P80313|TCPH_MOUSE sp|Q9DCD0|6PGD_MOUSE sp|P61979|HNRPK_MOUSE sp|P46935|NEDD4_MOUSE sp|Q9CY58|PAIRB_MOUSE sp|Q9CPV4|GLOD4_MOUSE sp|Q8R0N6|HOT_MOUSE sp|Q9DB20|ATPO_MOUSE sp|Q6NZJ6|IF4G1_MOUSE sp|Q99L45|IF2B_MOUSE sp|P14685|PSMD3_MOUSE sp|Q9QYR9|ACOT2_MOUSE sp|Q9R0X4|ACOT9_MOUSE sp|Q9CQF9|PCYOX_MOUSE sp|P19157|GSTP1_MOUSE sp|Q60668|HNRPD_MOUSE sp|P51150|RAB7A_MOUSE sp|Q6P5E4|UGGG1_MOUSE tr|Q8C3V4|Q8C3V4_MOUSE sp|O08788|DCTN1_MOUSE sp|Q8R081|HNRPL_MOUSE sp|Q8R180|ERO1A_MOUSE sp|O35857|TIM44_MOUSE sp|Q8K411|PREP_MOUSE sp|Q64521|GPDM_MOUSE sp|P46471|PRS7_MOUSE sp|P12970|RL7A_MOUSE sp|Q64737|PUR2_MOUSE sp|Q9Z247|FKBP9_MOUSE sp|P60843|IF4A1_MOUSE sp|Q91VM9|IPYR2_MOUSE sp|P31324|KAP3_MOUSE sp|Q3U0V1|FUBP2_MOUSE sp|Q9D0E1-2|HNRPM_MOUSE sp|Q9WTI7|MYO1C_MOUSE sp|P17563|SBP1_MOUSE sp|Q99LF4|RTCB_MOUSE sp|P63276|RS17_MOUSE sp|Q00612|G6PD1_MOUSE sp|P62843|RS15_MOUSE sp|Q9D8E6|RL4_MOUSE sp|P50580|PA2G4_MOUSE sp|P10630|IF4A2_MOUSE sp|Q8VCT4|CES1D_MOUSE sp|P26645|MARCS_MOUSE sp|Q9ERU9|RBP2_MOUSE sp|Q9CZW5|TOM70_MOUSE sp|Q5XJY5|COPD_MOUSE
1730.54 1639.09 2497.2 1441.58 2259.65 1500.94 1724.29 1840.42 2490.86 2576.04 1989.56 2029.88 2208.41 1163.31 1290.27 1662.01 1808.57 2181.3 2899.55 1915.35 1444.06 1949.39 2317.51 1477.17 1736.92 2096.74 2245.44 1520.14 1298.76 1727.16 1987.79 1702.1 1626.81 1192.92 1280.73 1387.31 2184.49 1696.9 1774.55 1625.7 2073.72 1662.62 1656.84 1748.53 2020.27 1474.92 1551.48 1293.77 1342.87 1692.87 1521.43 1701.64 1299.8 1364.51 1835 1675.13 1985.11 2029.3 2157.12 879.598 1352.52 1825.91
1324.96 1079.64 1749.86 3105.4 3201.2 1443.9 1737.61 1326.11 1793.84 5717.32 2456.43 1885.18 2260.62 1711.9 3295.08 2400.87 2333.17 1126.29 2041.5 1517.99 758.369 1635.43 1613.68 2653.39 1789.62 1438.82 2219.22 1637.98 1220.72 2294.04 2344.31 1659.36 1583.83 1632.26 2631 3885.6 1983.71 1789.36 1405.63 2324.77 1995.68 2443.65 904.885 1805.87 1162.51 2045.58 1572.16 2802.63 2036.23 2123.73 2117.53 1704.25 2182.54 1417.47 1909.7 2781.88 1481.77 1849.85 786.056 4083.95 4679.8 2250.34
1270.41 1602.08 4462.56 3357.39 4344.8 2689.57 4038.56 1358.53 1235.28 3159.38 3705.06 2174.52 3547.59 4708.7 2052.53 2239.03 3759.09 1821.19 2918.85 2774.27 1708.87 1555.72 2469.39 2785.91 1457.71 2027.22 2159.21 1480.22 1685.88 4220.94 1842.21 1576.38 2091.35 1866.43 4714.73 1746.83 3237.35 2072.28 1625.94 2445.79 1753.59 2233.07 1568.16 1717.02 3129.76 2354.13 2925.14 3407.55 1508.15 2059.62 2777.58 3138.35 2253.97 2561.81 2153.21 2451.87 1810.39 3351.12 1114.74 5510.73 4269.96 2661.27
1.14 1.13 1.02 1.02 1.01 1.01 0.91 1.30 1.25 1.20 1.08 0.96 0.91 1.34 1.13 1.07 1.05 1.05 0.99 0.90 0.82 1.81 1.25 1.23 1.19 1.03 1.02 0.97 0.95 0.86 1.25 1.23 1.17 1.16 1.12 1.11 1.11 1.10 1.08 1.05 1.05 1.02 1.01 0.97 0.97 0.95 0.93 1.19 1.10 1.04 1.04 1.03 1.01 0.98 0.95 0.93 0.86 2.80 1.57 1.35 1.25 1.21
0.70 0.72 1.16 2.04 1.70 1.21 1.37 0.88 0.77 2.20 1.40 0.93 1.23 3.09 2.18 1.35 1.84 0.74 0.82 0.94 0.59 1.12 1.16 2.04 1.08 0.78 0.88 0.93 0.96 1.55 1.16 1.02 1.15 1.51 3.21 1.99 1.19 1.08 0.87 1.46 0.97 1.43 0.77 0.93 1.01 1.28 1.24 2.71 1.33 1.23 1.51 1.43 1.48 1.30 1.09 1.45 0.77 3.14 0.76 7.46 4.12 1.57
ACCEPTED MANUSCRIPT
1343.92 1340.1 1738.5 1347.72 1154.71 1721.09 1322.41 1362.48 1081.79 1799.11 1516.52 1533.9 1359.42 1120.05 1356 1596.5 1626.61 1713.49 1206.39 1720.85 1462.89 1645.4 1063.44 1012.66 1383.52 1057.6 1181.25 1255.17 1104 1451.48 1489.92 1560.36 1006.51 1101.09 1727.58 1318.15 1548.06 1428.87 1316.77 1993.53 1727.37 1836.82 2336.67 922.413 1259.25 1467.55 1251.05 1605.85 1265.07 1446.23 1387.25 1122.74 1165.56 1843.5 1078.83 1422.38 2458.21 409.228 1454.65 1162.85 1745.96 1327.2
1784.51 1806.15 1738.88 1644.63 1354.7 1521.57 2141.01 2073.82 1510.62 1788.63 1725.09 1616.89 1799.25 1304.72 1795.41 2006.79 1905.81 1720.65 1842.71 1509.34 1713.8 2273.55 1724.66 1327.71 1728.11 1594.03 1692.47 1579.11 1378.48 1732.16 1652.78 1645.34 1264.08 1253.27 1469.44 1385.42 1543.17 1439.01 1538.43 1734.81 1789.26 1644.86 1844.86 1330.86 1744.31 2033.76 1287.9 1778.46 1384.1 1576.67 1562.56 1509.04 1416.85 1761.7 1243.19 1477.36 2340.9 2808.94 2230.84 1701.86 1737.97 1582.94
RI PT
1424.04 1490.82 1787.56 1554.94 1255.32 1642.06 1441.4 1273.08 1007.27 1265.92 1313.8 1283.86 1489.77 1102.06 1720.66 1912.8 1651.84 1463.56 2034.61 1405.31 1995.46 1585.31 1392.86 960.026 1258.47 1339.58 1362.25 1447.35 1098.28 1602.38 1479.94 1650.59 1281.97 1257.06 1234.62 1469.1 1653.12 1660.47 1650.24 1169.11 1841.94 1746.35 2623.23 1060.86 1292.81 1703.63 1235.02 1441.36 1328.33 1632.06 1520.44 1579.62 1343.31 1576.76 1397.84 1462.12 2523.9 1306.95 1368.46 1402.33 1450.88 1368.03
SC
31 31 31 31 31 31 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 28 28 28 28 28 28 28 28 28 28 28 28 28 28 27 27 27 27 27
M AN U
TE D
AP1B1_MOUSE AP-1 complex subunit beta-1 F8VQJ3_MOUSE Laminin subunit gamma-1 GLNA_MOUSE Glutamine synthetase GBLP_MOUSE Guanine nucleotide-binding protein subunit beta-2-like 1 SEPT2_MOUSE Septin-2 PRDX2_MOUSE Peroxiredoxin-2 AACS_MOUSE Acetoacetyl-CoA synthetase MBB1A_MOUSE Myb-binding protein 1A COPG1_MOUSE Coatomer subunit gamma-1 IF5A1_MOUSE Eukaryotic translation initiation factor 5A-1 E9PVA8_MOUSE Protein Gcn1l1 HDGF_MOUSE Hepatoma-derived growth factor PSMD1_MOUSE 26S proteasome non-ATPase regulatory subunit 1 SYIM_MOUSE Isoleucine--tRNA ligase, mitochondrial LAMP2_MOUSE Lysosome-associated membrane glycoprotein 2 SYK_MOUSE Lysine--tRNA ligase RS7_MOUSE 40S ribosomal protein S7 PEBP1_MOUSE Phosphatidylethanolamine-binding protein 1 PCCA_MOUSE Propionyl-CoA carboxylase alpha chain, mitochondrial CALM_MOUSE Calmodulin HYES_MOUSE Bifunctional epoxide hydrolase 2 GSLG1_MOUSE Golgi apparatus protein 1 MPRI_MOUSE Cation-independent mannose-6-phosphate receptor TCPG_MOUSE T-complex protein 1 subunit gamma RCN1_MOUSE Reticulocalbin-1 AL1L2_MOUSE Mitochondrial 10-formyltetrahydrofolate dehydrogenase CCD47_MOUSE Coiled-coil domain-containing protein 47 SC31A_MOUSE Protein transport protein Sec31A CKAP4_MOUSE Cytoskeleton-associated protein 4 PPCE_MOUSE Prolyl endopeptidase SEPT9_MOUSE Septin-9 ERF1_MOUSE Eukaryotic peptide chain release factor subunit 1 UCRI_MOUSE Cytochrome b-c1 complex subunit Rieske, mitochondrial GDIR1_MOUSE Rho GDP-dissociation inhibitor 1 DDX5_MOUSE Probable ATP-dependent RNA helicase DDX5 ALD2_MOUSE Aldose reductase-related protein 2 RS6_MOUSE 40S ribosomal protein S6 WDR1_MOUSE WD repeat-containing protein 1 IF2B2_MOUSE Insulin-like growth factor 2 mRNA-binding protein 2 E9QP99_MOUSE Golgin subfamily A member 3 CLYBL_MOUSE Citrate lyase subunit beta-like protein, mitochondrial PPID_MOUSE Peptidyl-prolyl cis-trans isomerase D APMAP_MOUSE Adipocyte plasma membrane-associated protein DIC_MOUSE Mitochondrial dicarboxylate carrier USO1_MOUSE General vesicular transport factor p115 TPP2_MOUSE Tripeptidyl-peptidase 2 DHB4_MOUSE Peroxisomal multifunctional enzyme type 2 ICAL_MOUSE Calpastatin CLU_MOUSE Clustered mitochondria protein homolog RL18_MOUSE 60S ribosomal protein L18 ARF5_MOUSE ADP-ribosylation factor 5 ODO1_MOUSE 2-oxoglutarate dehydrogenase, mitochondrial UBP14_MOUSE Ubiquitin carboxyl-terminal hydrolase 14 F10A1_MOUSE Hsc70-interacting protein VATA_MOUSE V-type proton ATPase catalytic subunit A PSA5_MOUSE Proteasome subunit alpha type-5 EP15R_MOUSE Epidermal growth factor receptor substrate 15-like 1 CO1A1_MOUSE Collagen alpha-1(I) chain APOOL_MOUSE Apolipoprotein O-like ATLA3_MOUSE Atlastin-3 KCY_MOUSE UMP-CMP kinase SERA_MOUSE D-3-phosphoglycerate dehydrogenase
EP
Ap1b1 Lamc1 Glul Gnb2l1 02-Sep Prdx2 Aacs Mybbp1a Copg1 Eif5a Gcn1l1 Hdgf Psmd1 Iars2 Lamp2 Kars Rps7 Pebp1 Pcca Calm1 Ephx2 Glg1 Igf2r Cct3 Rcn1 Aldh1l2 Ccdc47 Sec31a Ckap4 Prep 09-Sep Etf1 Uqcrfs1 Arhgdia Ddx5 Akr1b8 Rps6 Wdr1 Igf2bp2 Golga3 Clybl Ppid Apmap Slc25a10 Uso1 Tpp2 Hsd17b4 Cast Cluh Rpl18 Arf5 Ogdh Usp14 St13 Atp6v1a Psma5 Eps15l1 Col1a1 Apool Atl3 Cmpk1 Phgdh
AC C
sp|O35643|AP1B1_MOUSE tr|F8VQJ3|F8VQJ3_MOUSE sp|P15105|GLNA_MOUSE sp|P68040|GBLP_MOUSE sp|P42208|SEPT2_MOUSE sp|Q61171|PRDX2_MOUSE sp|Q9D2R0|AACS_MOUSE sp|Q7TPV4|MBB1A_MOUSE sp|Q9QZE5|COPG1_MOUSE sp|P63242|IF5A1_MOUSE tr|E9PVA8|E9PVA8_MOUSE sp|P51859|HDGF_MOUSE sp|Q3TXS7|PSMD1_MOUSE sp|Q8BIJ6|SYIM_MOUSE sp|P17047|LAMP2_MOUSE sp|Q99MN1|SYK_MOUSE sp|P62082|RS7_MOUSE sp|P70296|PEBP1_MOUSE sp|Q91ZA3|PCCA_MOUSE sp|P62204|CALM_MOUSE sp|P34914|HYES_MOUSE sp|Q61543|GSLG1_MOUSE sp|Q07113|MPRI_MOUSE sp|P80318|TCPG_MOUSE sp|Q05186|RCN1_MOUSE sp|Q8K009|AL1L2_MOUSE sp|Q9D024|CCD47_MOUSE sp|Q3UPL0|SC31A_MOUSE sp|Q8BMK4|CKAP4_MOUSE sp|Q9QUR6|PPCE_MOUSE sp|Q80UG5|SEPT9_MOUSE sp|Q8BWY3|ERF1_MOUSE sp|Q9CR68|UCRI_MOUSE sp|Q99PT1|GDIR1_MOUSE sp|Q61656|DDX5_MOUSE sp|P45377|ALD2_MOUSE sp|P62754|RS6_MOUSE sp|O88342|WDR1_MOUSE sp|Q5SF07|IF2B2_MOUSE tr|E9QP99|E9QP99_MOUSE sp|Q8R4N0|CLYBL_MOUSE sp|Q9CR16|PPID_MOUSE sp|Q9D7N9|APMAP_MOUSE sp|Q9QZD8|DIC_MOUSE sp|Q9Z1Z0|USO1_MOUSE sp|Q64514|TPP2_MOUSE sp|P51660|DHB4_MOUSE sp|P51125|ICAL_MOUSE sp|Q5SW19|CLU_MOUSE sp|P35980|RL18_MOUSE sp|P84084|ARF5_MOUSE sp|Q60597|ODO1_MOUSE sp|Q9JMA1|UBP14_MOUSE sp|Q99L47|F10A1_MOUSE sp|P50516|VATA_MOUSE sp|Q9Z2U1|PSA5_MOUSE sp|Q60902|EP15R_MOUSE sp|P11087|CO1A1_MOUSE sp|Q78IK4|APOOL_MOUSE sp|Q91YH5|ATLA3_MOUSE sp|Q9DBP5|KCY_MOUSE sp|Q61753|SERA_MOUSE
1513.56 1345.74 1970.93 1397.4 1129.84 1381.98 2029.39 1780.48 1272.79 2232.53 1762.4 1581.65 1434.34 1212.24 1536.11 1767.77 1617.6 1544.24 1314.88 1364.04 1326.74 2008.98 1305.35 1084.12 1384.57 1194.09 1160.97 1430.85 1061.56 1603.55 1530.04 1709.57 1100.41 1143.34 1541.02 1442.13 1636.4 1531.43 1300.74 1261.05 1504.54 1376.64 1611.86 1582.2 1248.53 1537.57 1400.8 1459.99 1290.31 1581.29 1375.99 1217.5 1089.35 1546.67 1021.45 1147.6 1791.85 779.325 2095.81 1267.14 1833.17 1310.33
2523.94 947.977 841.277 2802.96 1319.4 1309.2 2076.95 1972.29 2060.96 2291.58 2536.07 2185.85 2590.53 2437.17 1123.11 2274.64 1494.45 1349.03 1492.69 1218.7 1481.97 1998.45 1345.88 2716.14 1241.41 1737.09 1546.29 2208.46 1313.42 2130.61 2055.07 2257.09 855.312 1062.85 2188.25 1745.38 1852.06 3458.13 1189.5 1587.86 1406.2 3332.1 1735.27 1343.82 2085.23 1974.04 1695.7 626.351 1584.77 1394.11 1635.2 2330.87 1860.73 1908.15 2061.26 1425.27 1271.52 403.148 1545.67 1122.43 1192.42 2145.76
2290.15 1339.4 4820.28 2349.36 1402.59 2315.85 2196.88 1918.47 1829.07 5484 1998.79 3900.52 2238.33 2446.39 1217.98 1802.92 1752.78 2531.39 2149.5 3415.73 1742.61 1520.56 1023.34 1841.99 2203.88 999.796 1431.28 2890.49 1115.11 1393.42 1654.6 1869.88 1058.42 1446.54 4538.97 1968.32 2962.04 2999.27 1281.76 1549.8 2199.96 4319.73 1763.2 1250.14 1631.44 1613.3 1609.17 1340.41 2004.48 996.688 1310.28 2212.69 1490.23 3617.88 1865.36 1924.39 2116.9 392.783 1302.57 944.65 2360.09 2705.1
1.19 1.11 1.05 1.05 1.03 0.86 1.51 1.46 1.33 1.31 1.23 1.14 1.13 1.13 1.08 1.08 1.07 1.03 0.97 0.92 0.88 1.33 1.23 1.22 1.18 1.16 1.12 1.11 1.11 1.09 1.07 1.04 1.03 1.02 1.02 1.01 0.99 0.96 0.96 0.95 0.92 0.84 0.70 1.47 1.17 1.13 1.08 1.06 1.03 1.03 1.01 1.01 1.00 0.97 0.91 0.91 0.83 2.09 1.53 1.16 1.12 1.07
1.74 0.81 1.61 1.78 1.13 1.08 1.55 1.48 1.86 2.54 1.60 2.16 1.69 2.20 0.76 1.16 0.99 1.22 1.12 1.48 0.93 1.09 0.96 2.31 1.30 1.14 1.17 1.89 1.10 1.15 1.25 1.29 0.84 1.06 2.27 1.33 1.50 2.09 0.83 0.99 1.01 2.14 0.71 1.31 1.46 1.13 1.33 0.65 1.38 0.78 1.01 1.68 1.34 1.62 1.59 1.16 0.68 0.46 1.01 0.81 1.11 1.80
ACCEPTED MANUSCRIPT
TE D
1890.59 1313.62 1167.66 1260.64 1480.07 1804.42 1552.93 1387.42 1116.94 1530.7 1572.16 2304.06 1551.14 1604.63 1435.62 1890.29 1062.12 2590.7 986.584 914.476 756.134 1219.63 1383.58 1145.15 916.27 1263.78 1043.34 1339.7 1070.62 1662.36 1530.15 430.317 1380.48 1198.14 1193.28 988.719 1176.13 1331.27 835.237 1171.54 987.943 976.321 1843.01 958.195 801.876 961.238 1438.68 1332.03 1098.24 1356.49 1081.08 1090.93 1556.64 1307.44 882.176 1612.77 1089.26 1392.33 1151.79 1574.62 1661.79 1415.65
2096.67 1860.39 1557.65 1377.14 1747.1 1847.67 1433.76 1394.3 1104.86 1927.68 1630.37 2231.78 1570.39 1570.17 1270.5 1726.55 1504.62 2891.78 1331.6 1333.07 1406.39 1700.12 1691.14 1517.16 972.41 1345.63 1204.75 1284.9 1160.76 1618.03 1491.18 415.023 1392.21 1082.83 1798.89 1287.77 1633.16 1669.8 1122.97 1496.3 1243.97 1539.07 2313.48 1321.74 1162.25 1034.19 2107.3 1378.3 1397.24 1383.21 1146.26 1222.87 1962.18 1710.11 999.134 1812.41 1252.45 1461.56 1074.8 1413.75 1555.07 1388.86
RI PT
2197.04 1715.09 1380.49 1145.91 1553.67 1795.27 1404.8 1229.69 1096.65 2099.47 1459.93 2105.93 1550.66 1623.52 1304.14 1715.28 1216.37 1452.61 1074.48 1014.47 1160.73 1567.54 1544.93 1435.44 837.771 1318.17 1195.54 1191.16 1360.32 1629.79 1454.81 388.48 1266.45 1334.32 1323.11 1028.51 1192.77 1285.12 894.516 1080.29 1113.5 1369.41 1962.26 1159.3 975.584 927.992 1780.18 1312.49 1311.43 1347.98 933.753 1109.96 2010.87 1611.38 1065.7 1903.1 1309.59 1543.26 1015.9 1384.1 1681.5 1434.93
SC
27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25
M AN U
ADT1_MOUSE ADP/ATP translocase 1 LRP1_MOUSE Prolow-density lipoprotein receptor-related protein 1 EIF3C_MOUSE Eukaryotic translation initiation factor 3 subunit C CYB5_MOUSE Cytochrome b5 IF2B3_MOUSE Insulin-like growth factor 2 mRNA-binding protein 3 LGUL_MOUSE Lactoylglutathione lyase FKBP4_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP4 SYAP1_MOUSE Synapse-associated protein 1 SPEE_MOUSE Spermidine synthase ABCF1_MOUSE ATP-binding cassette sub-family F member 1 Q3UJB0_MOUSE Protein Sf3b2 RL23A_MOUSE 60S ribosomal protein L23a PRS6B_MOUSE 26S protease regulatory subunit 6B CLIC4_MOUSE Chloride intracellular channel protein 4 PEX19_MOUSE Peroxisomal biogenesis factor 19 ERP29_MOUSE Endoplasmic reticulum resident protein 29 PRP8_MOUSE Pre-mRNA-processing-splicing factor 8 CBR2_MOUSE Carbonyl reductase [NADPH] 2 PSMD2_MOUSE 26S proteasome non-ATPase regulatory subunit 2 SCFD1_MOUSE Sec1 family domain-containing protein 1 MARC2_MOUSE Mitochondrial amidoxime reducing component 2 AL7A1_MOUSE Alpha-aminoadipic semialdehyde dehydrogenase SF3B1_MOUSE Splicing factor 3B subunit 1 CLPX_MOUSE ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial Q6ZWZ6_MOUSE 40S ribosomal protein S12 KINH_MOUSE Kinesin-1 heavy chain RUVB1_MOUSE RuvB-like 1 AN32A_MOUSE Acidic leucine-rich nuclear phosphoprotein 32 family member A ETFD_MOUSE Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial IF5_MOUSE Eukaryotic translation initiation factor 5 STRAP_MOUSE Serine-threonine kinase receptor-associated protein RINI_MOUSE Ribonuclease inhibitor CLIP1_MOUSE CAP-Gly domain-containing linker protein 1 RS8_MOUSE 40S ribosomal protein S8 SYTC_MOUSE Threonine--tRNA ligase, cytoplasmic E41L2_MOUSE Band 4.1-like protein 2 RS4X_MOUSE 40S ribosomal protein S4, X isoform RS18_MOUSE 40S ribosomal protein S18 SYRC_MOUSE Arginine--tRNA ligase, cytoplasmic THIL_MOUSE Acetyl-CoA acetyltransferase, mitochondrial ADT2_MOUSE ADP/ATP translocase 2 U5S1_MOUSE 116 kDa U5 small nuclear ribonucleoprotein component RS3_MOUSE 40S ribosomal protein S3 SMC3_MOUSE Structural maintenance of chromosomes protein 3 PUR9_MOUSE Bifunctional purine biosynthesis protein PURH COPB_MOUSE Coatomer subunit beta NMT1_MOUSE Glycylpeptide N-tetradecanoyltransferase 1 TIF1B_MOUSE Transcription intermediary factor 1-beta E41L1_MOUSE Isoform 2 of Band 4.1-like protein 1 ERF3A_MOUSE Eukaryotic peptide chain release factor GTP-binding subunit ERF3A UB2L3_MOUSE Ubiquitin-conjugating enzyme E2 L3 HS71A_MOUSE Heat shock 70 kDa protein 1A LA_MOUSE Lupus La protein homolog ECI1_MOUSE Enoyl-CoA delta isomerase 1, mitochondrial AHSA1_MOUSE Activator of 90 kDa heat shock protein ATPase homolog 1 PRS8_MOUSE 26S protease regulatory subunit 8 HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mitochondrial PLST_MOUSE Plastin-3 PRC2C_MOUSE Protein PRRC2C YBOX1_MOUSE Nuclease-sensitive element-binding protein 1 GSTO1_MOUSE Glutathione S-transferase omega-1 RB6I2_MOUSE ELKS/Rab6-interacting/CAST family member 1
EP
Slc25a4 Lrp1 Eif3c Cyb5a Igf2bp3 Glo1 Fkbp4 Syap1 Srm Abcf1 Sf3b2 Rpl23a Psmc4 Clic4 Pex19 Erp29 Prpf8 Cbr2 Psmd2 Scfd1 02-Mar Aldh7a1 Sf3b1 Clpx Rps12 Kif5b Ruvbl1 Anp32a Etfdh Eif5 Strap Rnh1 Clip1 Rps8 Tars Epb41l2 Rps4x Rps18 Rars Acat1 Slc25a5 Eftud2 Rps3 Smc3 Atic Copb1 Nmt1 Trim28 Epb41l1 Gspt1 Ube2l3 Hspa1a Ssb Eci1 Ahsa1 Psmc5 Hmgcl Pls3 Prrc2c Ybx1 Gsto1 Erc1
AC C
sp|P48962|ADT1_MOUSE sp|Q91ZX7|LRP1_MOUSE sp|Q8R1B4|EIF3C_MOUSE sp|P56395|CYB5_MOUSE sp|Q9CPN8|IF2B3_MOUSE sp|Q9CPU0|LGUL_MOUSE sp|P30416|FKBP4_MOUSE sp|Q9D5V6|SYAP1_MOUSE sp|Q64674|SPEE_MOUSE sp|Q6P542|ABCF1_MOUSE tr|Q3UJB0|Q3UJB0_MOUSE sp|P62751|RL23A_MOUSE sp|P54775|PRS6B_MOUSE sp|Q9QYB1|CLIC4_MOUSE sp|Q8VCI5|PEX19_MOUSE sp|P57759|ERP29_MOUSE sp|Q99PV0|PRP8_MOUSE sp|P08074|CBR2_MOUSE sp|Q8VDM4|PSMD2_MOUSE sp|Q8BRF7|SCFD1_MOUSE sp|Q922Q1|MARC2_MOUSE sp|Q9DBF1|AL7A1_MOUSE sp|Q99NB9|SF3B1_MOUSE sp|Q9JHS4|CLPX_MOUSE tr|Q6ZWZ6|Q6ZWZ6_MOUSE sp|Q61768|KINH_MOUSE sp|P60122|RUVB1_MOUSE sp|O35381|AN32A_MOUSE sp|Q921G7|ETFD_MOUSE sp|P59325|IF5_MOUSE sp|Q9Z1Z2|STRAP_MOUSE sp|Q91VI7|RINI_MOUSE sp|Q922J3|CLIP1_MOUSE sp|P62242|RS8_MOUSE sp|Q9D0R2|SYTC_MOUSE sp|O70318|E41L2_MOUSE sp|P62702|RS4X_MOUSE sp|P62270|RS18_MOUSE sp|Q9D0I9|SYRC_MOUSE sp|Q8QZT1|THIL_MOUSE sp|P51881|ADT2_MOUSE sp|O08810|U5S1_MOUSE sp|P62908|RS3_MOUSE sp|Q9CW03|SMC3_MOUSE sp|Q9CWJ9|PUR9_MOUSE sp|Q9JIF7|COPB_MOUSE sp|O70310|NMT1_MOUSE sp|Q62318|TIF1B_MOUSE sp|Q9Z2H5-2|E41L1_MOUSE sp|Q8R050|ERF3A_MOUSE sp|P68037|UB2L3_MOUSE sp|Q61696|HS71A_MOUSE sp|P32067|LA_MOUSE sp|P42125|ECI1_MOUSE sp|Q8BK64|AHSA1_MOUSE sp|P62196|PRS8_MOUSE sp|P38060|HMGCL_MOUSE sp|Q99K51|PLST_MOUSE sp|Q3TLH4|PRC2C_MOUSE sp|P62960|YBOX1_MOUSE sp|O09131|GSTO1_MOUSE sp|Q99MI1|RB6I2_MOUSE
2270.39 1360.17 1119.9 1125.49 1399.55 1839.88 1543.98 1114.42 1003.29 1527.13 1203.11 1885.68 1322.25 1394.89 1183.83 1480.98 1491.12 2267.3 1275.98 1031.63 924.233 1402.3 1522.92 1087.75 789.003 1205.01 965.513 1146.48 1174 1540.93 1341.4 359.424 1088.01 1255.01 1579.57 1327.86 1309.28 1539.35 986.32 1241.04 1290.83 1252.44 2141.78 1119.46 868.544 1111.04 1475.5 1537.62 1195.56 1444.75 957.345 1065.09 1649.55 1203.33 919.802 1496.82 943.455 1196.56 882.334 1250.48 1440.27 1112.96
2326.69 1653.48 2140.88 826.751 2411.16 501.671 2116.67 996.816 1189.34 1504.86 1077.84 1554.98 1354.95 1570.5 999.25 1435.91 1570.95 1816.74 1340.7 1503.37 3087.31 1308.19 1395.77 1011.42 2932.87 2240.85 2630.81 2114.35 1973.51 2093.99 1792.85 3744.65 1150.41 1329.3 1755.97 977.543 1668.46 1470.43 2761.79 2780.48 2374.69 1765.53 2302.08 1152.92 1011.12 1480.65 1582.42 2320.99 1017.5 1772.83 868.933 1296.65 1447.77 1144.4 1054.33 1884.9 1052.27 1847.56 798.114 1074.33 1573.08 1003.5
1656.74 1278.74 1821.57 2390.85 3228.48 1585.01 1967.46 2029.59 1449.57 2004.6 1946.18 3304.11 1977.75 2105.98 2595.75 2176.95 910.591 2796.78 940.215 1563.71 2857.94 1260.39 1341.44 2954.85 5883.72 2641.72 2001.43 3784.65 1744.27 3142.56 3271.78 6990.77 2097.01 1703.71 1226.7 1462.29 1266.29 1267.53 1419.59 3482.01 1592.8 982.535 1635.81 938.151 894.31 1115.3 1435.11 2678.76 2210.11 1676.28 1791.08 1459.25 1615.1 2003.32 1301.67 2185.49 1855.75 1644.44 1643.08 3220.37 2660.91 1820.31
1.07 1.06 1.05 1.04 1.04 1.02 1.01 0.96 0.95 0.95 0.93 0.93 0.93 0.92 0.90 0.89 1.31 1.28 1.27 1.23 1.22 1.11 1.10 1.01 1.00 0.99 0.97 0.96 0.96 0.96 0.95 0.95 0.94 0.92 1.34 1.30 1.24 1.23 1.22 1.22 1.21 1.19 1.17 1.15 1.14 1.14 1.11 1.10 1.08 1.05 1.04 1.04 1.01 1.00 0.99 0.94 0.92 0.91 0.90 0.90 0.90 0.88
0.97 0.97 1.56 1.34 1.86 0.58 1.38 1.16 1.19 0.97 1.00 1.10 1.07 1.14 1.31 1.00 1.09 1.14 1.11 1.59 3.10 0.92 0.93 1.54 5.03 1.89 2.07 2.33 1.53 1.59 1.70 13.11 1.23 1.20 1.19 1.21 1.24 1.05 2.42 2.78 1.89 1.17 1.03 0.99 1.07 1.37 0.94 1.89 1.34 1.28 1.32 1.25 0.86 1.08 1.21 1.16 1.21 1.19 1.13 1.45 1.27 0.99
ACCEPTED MANUSCRIPT
1377.73 2431.98 1263.44 1630.95 1078.94 1407.34 930.67 1440.51 795.313 1159.5 1273.73 1401.22 859.125 1337.92 1136.92 1040.43 1002.13 1452.49 1073.08 730.091 866.997 1064.25 911.555 1134.39 1244.13 1572.58 981.412 1208.24 1718.42 1067.1 1942.46 873.403 1012.26 1103.03 1294.34 1316.5 857.495 1270.34 1215.55 1270.89 992.482 981.756 969.389 875.516 1089.8 1025.7 1207.61 1078.49 1398.45 1083.84 1074.13 1392.82 1209.2 480.552 814.846 850.3 1004.22 1396.87 1108.75 655.1 767.778 825.645
1109.4 1934.54 909.979 1700.91 1443.61 2310.21 1542.25 1499.18 1093.73 1555.13 1303.26 1495.35 1078 1172.08 1244.75 1205.64 1291.58 1231.15 1246.36 974.392 928.442 1307.86 821.18 1178.06 1363.08 1562.88 999.47 1082.94 1118.96 1469.93 2558.97 1140.91 1255.35 1467.1 1601.54 1421.62 988.125 1541.82 1404.74 1340.74 1202.17 1324.23 1095.04 945.038 1186.97 1128.38 1342.99 1123.7 1317.79 1061.95 1227.53 1128.84 1187.09 2982.03 1438.02 1342.98 1394.85 2054.54 1900.79 1171.43 1204.31 1327.85
RI PT
1281.28 2571.03 1306.57 1558.76 842.141 1156.86 1056.66 1076.77 895.343 1453.2 741.713 1307.68 954.506 1133.48 1154.26 1157.46 1247.92 1378.54 1104.54 1117.02 846.554 1408.84 838.199 1211.36 1460.39 1730.11 1139.71 1454.47 1036.62 825.21 2063.99 945.483 948.686 1184.61 1571.88 1436.13 904.303 1466.3 1311.47 1368.68 1183.76 1234.05 1119.05 902.661 1202.35 1068.61 1168.87 1089.78 1188.1 1067.9 1419.09 1074.67 1361.01 535.598 933.485 865.134 1076.87 1508.98 1093.79 883.089 854.977 958.752
SC
25 25 25 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 22 22 22 22 22 22 22 22 22
M AN U
TE D
Nln Aimp1 Akr1a1 Eci2 Gns Hsph1 Adh5 Hist1h1c Acaa1a Atp5f1 Spag9 Pfkp Pds5b Emc1 Rpn2 Slc25a22 Copb2 Ddx19a Cul1 Wars Sars Eif3l Dnaja3 Rpl13 Eif2s1 Nucb1 Lias Dctn2 Ppp1r7 Hnrnpul2 Cttn Psmb7 Ca3 Myh11 Phb2 Gstz1 Cyb5r3 Cdc42 Mccc1 Snd1 Asph
EIF3I_MOUSE Eukaryotic translation initiation factor 3 subunit I RISC_MOUSE Retinoid-inducible serine carboxypeptidase EIF3F_MOUSE Eukaryotic translation initiation factor 3 subunit F CAV1_MOUSE Caveolin-1 Q99JZ4_MOUSE GTP-binding protein SAR1a PPIB_MOUSE Peptidyl-prolyl cis-trans isomerase B Q91WU0_MOUSE Expressed sequence AU018778 AMRP_MOUSE Alpha-2-macroglobulin receptor-associated protein THIC_MOUSE Acetyl-CoA acetyltransferase, cytosolic U520_MOUSE U5 small nuclear ribonucleoprotein 200 kDa helicase VATE1_MOUSE V-type proton ATPase subunit E 1 COPA_MOUSE Coatomer subunit alpha API5_MOUSE Apoptosis inhibitor 5 UBR4_MOUSE E3 ubiquitin-protein ligase UBR4 ROA1_MOUSE Heterogeneous nuclear ribonucleoprotein A1 HP1B3_MOUSE Heterochromatin protein 1-binding protein 3 SYG_MOUSE Glycine--tRNA ligase ECH1_MOUSE Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial COBL1_MOUSE Cordon-bleu protein-like 1 VDAC2_MOUSE Voltage-dependent anion-selective channel protein 2 CK054_MOUSE Ester hydrolase C11orf54 homolog NEUL_MOUSE Neurolysin, mitochondrial AIMP1_MOUSE Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 AK1A1_MOUSE Alcohol dehydrogenase [NADP(+)] ECI2_MOUSE Isoform 2 of Enoyl-CoA delta isomerase 2, mitochondrial GNS_MOUSE N-acetylglucosamine-6-sulfatase HS105_MOUSE Heat shock protein 105 kDa ADHX_MOUSE Alcohol dehydrogenase class-3 H12_MOUSE Histone H1.2 THIKA_MOUSE 3-ketoacyl-CoA thiolase A, peroxisomal AT5F1_MOUSE ATP synthase F(0) complex subunit B1, mitochondrial JIP4_MOUSE C-Jun-amino-terminal kinase-interacting protein 4 K6PP_MOUSE 6-phosphofructokinase type C PDS5B_MOUSE Sister chromatid cohesion protein PDS5 homolog B EMC1_MOUSE Isoform 2 of ER membrane protein complex subunit 1 RPN2_MOUSE Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 GHC1_MOUSE Mitochondrial glutamate carrier 1 COPB2_MOUSE Coatomer subunit beta' DD19A_MOUSE ATP-dependent RNA helicase DDX19A CUL1_MOUSE Cullin-1 SYWC_MOUSE Tryptophan--tRNA ligase, cytoplasmic SYSC_MOUSE Serine--tRNA ligase, cytoplasmic EIF3L_MOUSE Eukaryotic translation initiation factor 3 subunit L DNJA3_MOUSE DnaJ homolog subfamily A member 3, mitochondrial RL13_MOUSE 60S ribosomal protein L13 IF2A_MOUSE Eukaryotic translation initiation factor 2 subunit 1 NUCB1_MOUSE Nucleobindin-1 LIAS_MOUSE Lipoyl synthase, mitochondrial DCTN2_MOUSE Dynactin subunit 2 PP1R7_MOUSE Protein phosphatase 1 regulatory subunit 7 HNRL2_MOUSE Heterogeneous nuclear ribonucleoprotein U-like protein 2 SRC8_MOUSE Src substrate cortactin PSB7_MOUSE Proteasome subunit beta type-7 CAH3_MOUSE Carbonic anhydrase 3 MYH11_MOUSE Myosin-11 PHB2_MOUSE Prohibitin-2 MAAI_MOUSE Maleylacetoacetate isomerase NB5R3_MOUSE NADH-cytochrome b5 reductase 3 CDC42_MOUSE Cell division control protein 42 homolog MCCA_MOUSE Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial SND1_MOUSE Staphylococcal nuclease domain-containing protein 1 ASPH_MOUSE Aspartyl/asparaginyl beta-hydroxylase
EP
Eif3i Scpep1 Eif3f Cav1 Sar1a Ppib Ces1f Lrpap1 Acat2 Snrnp200 Atp6v1e1 Copa Api5 Ubr4 Hnrnpa1 Hp1bp3 Gars Ech1 Cobll1 Vdac2
AC C
sp|Q9QZD9|EIF3I_MOUSE sp|Q920A5|RISC_MOUSE sp|Q9DCH4|EIF3F_MOUSE sp|P49817|CAV1_MOUSE tr|Q99JZ4|Q99JZ4_MOUSE sp|P24369|PPIB_MOUSE tr|Q91WU0|Q91WU0_MOUSE sp|P55302|AMRP_MOUSE sp|Q8CAY6|THIC_MOUSE sp|Q6P4T2|U520_MOUSE sp|P50518|VATE1_MOUSE sp|Q8CIE6|COPA_MOUSE sp|O35841|API5_MOUSE sp|A2AN08|UBR4_MOUSE sp|P49312|ROA1_MOUSE sp|Q3TEA8|HP1B3_MOUSE sp|Q9CZD3|SYG_MOUSE sp|O35459|ECH1_MOUSE sp|Q3UMF0|COBL1_MOUSE sp|Q60930|VDAC2_MOUSE sp|Q91V76|CK054_MOUSE sp|Q91YP2|NEUL_MOUSE sp|P31230|AIMP1_MOUSE sp|Q9JII6|AK1A1_MOUSE sp|Q9WUR2-2|ECI2_MOUSE sp|Q8BFR4|GNS_MOUSE sp|Q61699|HS105_MOUSE sp|P28474|ADHX_MOUSE sp|P15864|H12_MOUSE sp|Q921H8|THIKA_MOUSE sp|Q9CQQ7|AT5F1_MOUSE sp|Q58A65|JIP4_MOUSE sp|Q9WUA3|K6PP_MOUSE sp|Q4VA53|PDS5B_MOUSE sp|Q8C7X2-2|EMC1_MOUSE sp|Q9DBG6|RPN2_MOUSE sp|Q9D6M3|GHC1_MOUSE sp|O55029|COPB2_MOUSE sp|Q61655|DD19A_MOUSE sp|Q9WTX6|CUL1_MOUSE sp|P32921|SYWC_MOUSE sp|P26638|SYSC_MOUSE sp|Q8QZY1|EIF3L_MOUSE sp|Q99M87|DNJA3_MOUSE sp|P47963|RL13_MOUSE sp|Q6ZWX6|IF2A_MOUSE sp|Q02819|NUCB1_MOUSE sp|Q99M04|LIAS_MOUSE sp|Q99KJ8|DCTN2_MOUSE sp|Q3UM45|PP1R7_MOUSE sp|Q00PI9|HNRL2_MOUSE sp|Q60598|SRC8_MOUSE sp|P70195|PSB7_MOUSE sp|P16015|CAH3_MOUSE sp|O08638|MYH11_MOUSE sp|O35129|PHB2_MOUSE sp|Q9WVL0|MAAI_MOUSE sp|Q9DCN2|NB5R3_MOUSE sp|P60766|CDC42_MOUSE sp|Q99MR8|MCCA_MOUSE sp|Q78PY7|SND1_MOUSE sp|Q8BSY0|ASPH_MOUSE
1069.25 2142.85 1085.09 3292.41 1285.14 1326.66 1212.2 1721.2 933.766 1495.18 1036.04 1543.73 954.774 1576.31 1281.59 1202.91 1100.14 1670.74 952.165 768.673 673.544 947.634 763.659 933.391 1045.63 1350.25 828.857 1077.19 896.302 990.635 2236.9 1012.68 1028.6 1189.4 1680.48 1672.32 991.609 1452.63 1302.03 1477.93 1052.25 964.605 1033.16 852.365 1124.25 967.21 982.585 951.735 1124.15 910.738 1027.75 1097.46 1086.19 3482.27 1421.55 1182.87 1642.93 2147.56 1269.87 889.489 944.846 1007.38
2143.59 1648.33 1228.02 1517.22 1432.85 1608.39 1620.13 655.836 832.663 1580.64 1447.86 1590.42 1095.21 1899.87 1338.71 1589.56 2050.59 2047.45 1414 3316.23 797.778 1023.85 1137.71 959.912 1767 1288.43 2346.64 1397.65 1939.01 1670.49 1894.98 1306.02 2697.79 2028.64 1584.04 1405.51 2462.9 1828.95 1746.82 1196.62 1540.06 1455.75 1229.6 986.268 831.561 1796.09 595.433 1009.83 1136.9 1029.99 1591.12 842.201 1157.57 84.7096 1737.03 1388.56 732.013 2272.51 1578.07 1334.51 1141.3 1125.3
3461.93 1704.73 1346.46 1165.6 1632.82 1488.38 1873.44 1072.16 1000.65 1041.23 1795.85 1404.48 720.141 1850.24 1687.49 1426.49 1626.73 1597.11 2543.05 1052.31 2103.5 1220.85 2081.32 1592.1 2156.9 1345.87 1916.57 1591.14 1561.63 2210.3 1519.17 1930.83 1367.55 2450.37 1297.28 1207.55 1989.58 1373.31 1469.01 995.113 1233.71 1198.37 807.335 1424.25 1075.1 1444.8 1529.61 1763.33 2247.98 1724.49 1559.51 1255.28 1408.29 377.346 916.471 920.947 809.896 1550.75 1354.46 2716.71 1007.29 1009.72
0.82 0.81 0.78 1.57 1.42 1.42 1.39 1.28 1.20 1.17 1.16 1.12 1.12 1.11 1.10 1.10 1.06 1.03 1.01 0.94 0.93 0.91 0.91 0.90 0.89 0.88 0.86 0.81 0.73 1.30 1.20 1.18 1.16 1.16 1.15 1.12 1.12 1.09 1.07 1.07 1.04 1.03 1.02 1.01 1.01 1.00 0.98 0.96 0.94 0.92 0.90 0.90 0.88 6.36 1.64 1.47 1.46 1.45 1.44 1.34 1.32 1.31
2.11 0.67 1.00 0.84 1.60 1.21 1.76 0.69 1.08 1.00 1.61 1.11 1.00 1.52 1.32 1.37 1.63 1.29 1.82 2.37 1.69 0.91 1.84 1.09 1.45 0.80 2.01 1.12 1.27 2.05 0.85 1.78 2.07 1.96 1.01 0.95 2.53 1.17 1.27 0.83 1.27 1.20 0.98 1.36 0.83 1.55 0.89 1.28 1.31 1.28 1.26 0.85 1.00 0.45 1.52 1.35 0.74 1.32 1.33 2.63 1.32 1.20
ACCEPTED MANUSCRIPT
TE D
916.905 804.807 867.087 893.912 1172.87 886.118 1059.42 908.447 1059.93 1170.71 1366.2 1415.64 1147.44 1453.23 1047.62 1112.65 933.825 1062.94 1073.57 902.53 1229.58 906.305 1048.06 980.398 1036.27 1007.51 1143.01 1364.3 1455.94 735.898 535.745 875.483 837.192 1025.31 957.903 1006.06 1402.71 840.388 1042.54 955.739 959.19 946.391 1140.09 806.928 1272.53 1024.94 747.927 1516.93 1329.27 1167.71 1647.9 1522 1938.75 1136.52 1132.7 682.683 719.674 776.377 939.79 1480.39 1150.61 1073.21
1389.48 1036.78 1447.34 1456.3 1033.56 1298.83 1619.84 1271 1435.56 1531.56 1691.11 1859.88 1556.48 1807.5 1399.29 1297.52 1181.82 1010.81 1112.64 1000.91 1504.34 826.91 1187.77 1110.5 1000.42 1096.51 1168.05 1326.48 1116.94 1470.37 1080.11 1959.58 1489.62 1576.76 1293.94 1503.34 2019.94 1104.44 954.804 1304.4 894.471 1107.14 1103.45 966.239 1453.35 955.876 1000.28 1525.96 1310.17 1042.5 1612.42 1280.23 1269.84 985.231 1569.53 925.536 1164.19 1259.44 1317.38 1777.87 1745.09 1423.52
RI PT
1034.6 808.851 1037.62 1080.23 769.526 962.758 1229.6 1018 1191.67 1262.34 1495.62 1444.16 1334.4 1700.92 1233.38 1287.23 1157.98 1039.86 1212.4 931.996 1494.94 854.685 1205.96 1281.98 1093.44 1250.92 1413.57 1548.81 1553 623.442 710.393 1338.15 999.526 1235.02 1055.07 1125.14 1553.83 896.603 949.431 1030.88 799.278 862.528 987.479 869.143 1238 1032.15 966.029 1393.62 1202.95 1134.77 1641.35 1492.2 1551.15 1400.88 631.021 591.067 788.779 851.736 972.783 1208.29 1338.3 1083.61
SC
22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 20 20 20 20 20 20 20 20
M AN U
MIA3_MOUSE Melanoma inhibitory activity protein 3 PYR1_MOUSE CAD protein RAB1B_MOUSE Ras-related protein Rab-1B SYFB_MOUSE Phenylalanine--tRNA ligase beta subunit BTF3_MOUSE Transcription factor BTF3 RS19_MOUSE 40S ribosomal protein S19 ACD10_MOUSE Acyl-CoA dehydrogenase family member 10 VATC1_MOUSE V-type proton ATPase subunit C 1 NU214_MOUSE Nuclear pore complex protein Nup214 MAOM_MOUSE NAD-dependent malic enzyme, mitochondrial XPO1_MOUSE Exportin-1 FUS_MOUSE RNA-binding protein FUS SEPT7_MOUSE Septin-7 RL13A_MOUSE 60S ribosomal protein L13a EFGM_MOUSE Elongation factor G, mitochondrial RENT1_MOUSE Regulator of nonsense transcripts 1 IDHG1_MOUSE Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial VATB2_MOUSE V-type proton ATPase subunit B, brain isoform 2AAA_MOUSE Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform SRP68_MOUSE Signal recognition particle subunit SRP68 IMDH2_MOUSE Inosine-5'-monophosphate dehydrogenase 2 TBB5_MOUSE Tubulin beta-5 chain PGES2_MOUSE Prostaglandin E synthase 2 BLMH_MOUSE Bleomycin hydrolase NDUBA_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 LMNB1_MOUSE Lamin-B1 EIF3B_MOUSE Eukaryotic translation initiation factor 3 subunit B ITA6_MOUSE Integrin alpha-6 ANXA5_MOUSE Annexin A5 GSTM1_MOUSE Glutathione S-transferase Mu 1 AL1L1_MOUSE Cytosolic 10-formyltetrahydrofolate dehydrogenase CO5A1_MOUSE Collagen alpha-1(V) chain NOP56_MOUSE Nucleolar protein 56 MACF1_MOUSE Microtubule-actin cross-linking factor 1 NOMO1_MOUSE Nodal modulator 1 Q5XJF6_MOUSE Ribosomal protein CTGE5_MOUSE cTAGE family member 5 4F2_MOUSE 4F2 cell-surface antigen heavy chain RS23_MOUSE 40S ribosomal protein S23 SYFA_MOUSE Phenylalanine--tRNA ligase alpha subunit USP9X_MOUSE Probable ubiquitin carboxyl-terminal hydrolase FAF-X SUCA_MOUSE Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial RL23_MOUSE 60S ribosomal protein L23 DC1I2_MOUSE Cytoplasmic dynein 1 intermediate chain 2 QCR7_MOUSE Cytochrome b-c1 complex subunit 7 UBP5_MOUSE Ubiquitin carboxyl-terminal hydrolase 5 GSHR_MOUSE Glutathione reductase, mitochondrial BCLF1_MOUSE Bcl-2-associated transcription factor 1 GLRX3_MOUSE Glutaredoxin-3 CSDE1_MOUSE Cold shock domain-containing protein E1 HNRPC_MOUSE Heterogeneous nuclear ribonucleoproteins C1/C2 PSA4_MOUSE Proteasome subunit alpha type-4 NUDC_MOUSE Nuclear migration protein nudC LCAP_MOUSE Leucyl-cystinyl aminopeptidase H4_MOUSE Histone H4 SPRC_MOUSE SPARC ATAD3_MOUSE ATPase family AAA domain-containing protein 3 RAB1A_MOUSE Ras-related protein Rab-1A PUR6_MOUSE Multifunctional protein ADE2 FKBP7_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP7 ABCE1_MOUSE ATP-binding cassette sub-family E member 1 DDX21_MOUSE Nucleolar RNA helicase 2
EP
Mia3 Cad Rab1b Farsb Btf3 Rps19 Acad10 Atp6v1c1 Nup214 Me2 Xpo1 Fus septin7 Rpl13a Gfm1 Upf1 Idh3g Atp6v1b2 Ppp2r1a Srp68 Impdh2 Tubb5 Ptges2 Blmh Ndufb10 Lmnb1 Eif3b Itga6 Anxa5 Gstm1 Aldh1l1 Col5a1 Nop56 Macf1 Nomo1 Rpl10a Ctage5 Slc3a2 Rps23 Farsa Usp9x Suclg1 Rpl23 Dync1i2 Uqcrb Usp5 Gsr Bclaf1 Glrx3 Csde1 Hnrnpc Psma4 Nudc Lnpep Hist1h4a Sparc Atad3 Rab1A Paics Fkbp7 Abce1 Ddx21
AC C
sp|Q8BI84|MIA3_MOUSE sp|B2RQC6|PYR1_MOUSE sp|Q9D1G1|RAB1B_MOUSE sp|Q9WUA2|SYFB_MOUSE sp|Q64152|BTF3_MOUSE sp|Q9CZX8|RS19_MOUSE sp|Q8K370|ACD10_MOUSE sp|Q9Z1G3|VATC1_MOUSE sp|Q80U93|NU214_MOUSE sp|Q99KE1|MAOM_MOUSE sp|Q6P5F9|XPO1_MOUSE sp|P56959|FUS_MOUSE sp|O55131|SEPT7_MOUSE sp|P19253|RL13A_MOUSE sp|Q8K0D5|EFGM_MOUSE sp|Q9EPU0|RENT1_MOUSE sp|P70404|IDHG1_MOUSE sp|P62814|VATB2_MOUSE sp|Q76MZ3|2AAA_MOUSE sp|Q8BMA6|SRP68_MOUSE sp|P24547|IMDH2_MOUSE sp|P99024|TBB5_MOUSE sp|Q8BWM0|PGES2_MOUSE sp|Q8R016|BLMH_MOUSE sp|Q9DCS9|NDUBA_MOUSE sp|P14733|LMNB1_MOUSE sp|Q8JZQ9|EIF3B_MOUSE sp|Q61739|ITA6_MOUSE sp|P48036|ANXA5_MOUSE sp|P10649|GSTM1_MOUSE sp|Q8R0Y6|AL1L1_MOUSE sp|O88207|CO5A1_MOUSE sp|Q9D6Z1|NOP56_MOUSE sp|Q9QXZ0|MACF1_MOUSE sp|Q6GQT9|NOMO1_MOUSE tr|Q5XJF6|Q5XJF6_MOUSE sp|Q8R311|CTGE5_MOUSE sp|P10852|4F2_MOUSE sp|P62267|RS23_MOUSE sp|Q8C0C7|SYFA_MOUSE sp|P70398|USP9X_MOUSE sp|Q9WUM5|SUCA_MOUSE sp|P62830|RL23_MOUSE sp|O88487|DC1I2_MOUSE sp|Q9D855|QCR7_MOUSE sp|P56399|UBP5_MOUSE sp|P47791|GSHR_MOUSE sp|Q8K019|BCLF1_MOUSE sp|Q9CQM9|GLRX3_MOUSE sp|Q91W50|CSDE1_MOUSE sp|Q9Z204|HNRPC_MOUSE sp|Q9R1P0|PSA4_MOUSE sp|O35685|NUDC_MOUSE sp|Q8C129|LCAP_MOUSE sp|P62806|H4_MOUSE sp|P07214|SPRC_MOUSE sp|Q925I1|ATAD3_MOUSE sp|P62821|RAB1A_MOUSE sp|Q9DCL9|PUR6_MOUSE sp|O54998|FKBP7_MOUSE sp|P61222|ABCE1_MOUSE sp|Q9JIK5|DDX21_MOUSE
1080.08 961.204 903.112 956.071 1337.69 935.848 1129.94 1031.04 1219.57 1255.08 1551.06 1327.47 1186.38 1678.34 1112.94 1262.28 1037.34 1153.07 1234.04 829.21 1186.14 885.458 975.932 1058.62 1018.41 1004.54 1080.64 1102.95 839.943 1044.79 887.048 1198.88 1011.58 1226.57 1153.64 1069.68 1444.59 930.572 1349.7 943.104 1088.8 922.772 1265.68 846.186 1232.42 1143.5 719.338 1258.1 1086.1 1131.04 1413.95 1439.37 1414.42 913.64 1292.12 825.477 833.831 876.724 1101.26 1606.95 1387.7 1286.96
941.952 1814.58 928.484 1421.76 853.913 860.875 1445.53 1359.85 1476.04 1073.59 1857.22 2183.17 1703.23 1577.52 2027.33 1055.74 1509.83 1339.86 1694.02 2127.39 1524.62 1104.78 953.917 1106.74 718.933 941.695 1316.54 1177.46 1442.54 1318.92 1088.43 391.704 1492.94 1188.19 1035.62 1573.76 1238.25 1883.78 1881.08 1078.99 2416.98 1083.61 1213.27 801.969 1074.51 1183.39 968.949 796.162 1610.72 954.08 461.276 1674.11 1898.61 1545.18 1854.77 225.126 645.116 1144.11 1612.82 954.966 1144.69 1451.91
1561.01 1140.36 1031.24 1089.43 1503.48 1411.28 1675.26 917.145 1523.8 1137.99 1211.8 2965.55 1536.03 1165.2 1868.19 1196.66 2040.31 1526.22 1470.99 1713.59 1305.85 1301.8 1074.49 985.762 1283.88 937.061 1108.01 1286.89 375.485 1861.27 1139.9 513.854 701.208 1142.9 845.69 1238.49 1656.49 1019.7 2318.13 1136.5 1317.78 3135.28 2396.32 1153.82 2060.95 1361.78 998.118 1682.81 2983.91 1652.09 1658.24 1139.47 2619.2 758.159 673.826 604.667 801.888 800.008 973.023 2293.64 859.329 1791.44
1.27 1.24 1.23 1.22 1.22 1.21 1.20 1.19 1.18 1.15 1.13 1.11 1.11 1.11 1.10 1.07 1.06 1.03 1.03 1.00 0.99 0.97 0.96 0.96 0.95 0.93 0.88 0.83 0.65 1.85 1.58 1.43 1.36 1.24 1.22 1.21 1.17 1.17 1.16 1.13 1.13 1.12 1.11 1.08 1.07 1.02 1.00 0.96 0.95 0.94 0.92 0.90 0.77 0.75 1.62 1.37 1.32 1.31 1.26 1.26 1.26 1.26
1.28 1.83 1.03 1.27 1.21 1.23 1.36 1.18 1.33 0.91 1.07 1.80 1.31 0.87 1.71 0.94 1.70 1.36 1.38 2.09 1.04 1.37 0.90 0.92 0.94 0.83 0.95 0.85 0.60 2.34 1.79 0.41 1.19 1.03 0.93 1.32 0.98 1.67 2.11 1.12 2.12 2.33 1.70 1.17 1.25 1.24 1.15 0.85 1.81 1.13 0.64 0.93 1.29 0.91 1.43 0.65 0.96 1.19 1.35 1.21 0.81 1.50
ACCEPTED MANUSCRIPT
M AN U
TE D
875.43 1021.37 794.794 877.212 1022.3 1177.17 774.769 1032.01 788.548 918.394 1256.14 740.283 1061.34 805.222 904.597 1218.16 1029.1 1829.49 738.636 1009.95 886.662 907.53 891.791 930.671 952.4 939.188 749.485 1383.54 707.561 1559.45 1107.74 1283.27 1308.9 1567.7 1129.43 1066 1223.22 1050.36 1240.7 869.332 678.099 1220.99 759.505 913.39 870.235 997.806 951.915 845.18 1263.4 658.225 773.361 624.038 1065.13 782.375 865.525 746.17 670.49 1392.5 793.144 917.857 626.747 1162.81
993.105 1423.95 1261.73 1238.85 1342.61 1485.48 1119.46 1334.63 994.357 1225.82 1608.73 941.145 1083.29 1038.79 1102.54 1231.06 1293.39 1740.94 752.648 1314.43 1018.64 950.799 1000.61 943.894 900.585 857.742 849.719 1622.59 838.43 1267.98 1175.38 1253.38 1206.2 1531.93 1137.86 1020.82 996.533 1126.51 1070.51 1628.24 1148.64 1540.26 1164.32 1343.34 1023.76 1281.68 1135.32 977.536 1311.59 987.548 1075.45 613.438 1393.46 922.402 1058.24 1042.27 928.183 1151.17 1115.58 1259.17 759.319 1233.65
RI PT
725.872 1165.83 1107.89 1036.34 990.637 1291.42 1018.79 1200.43 966.98 1050.37 1392.65 848.288 1035.5 968.244 993.287 1275.58 1268.07 1487.35 698.415 1268.76 1046.9 870.897 1134.9 956.012 722.285 880.258 868.247 1754.29 960.405 1202.43 1261.5 1311.73 1243.2 1549.41 1254.1 1114.68 1340.47 1586.27 1347.85 857.965 736.153 1074.95 931.209 942.048 565.799 835.121 945.748 815.899 1014.85 875.34 855.91 514.573 1245.54 760.966 946.713 906.085 886.621 941.265 1030.78 1211.68 679.118 1301.17
SC
AKA12_MOUSE A-kinase anchor protein 12 20 VP13A_MOUSE Vacuolar protein sorting-associated protein 13A 20 CO6A1_MOUSE Collagen alpha-1(VI) chain 20 SAE2_MOUSE SUMO-activating enzyme subunit 2 20 COPG2_MOUSE Coatomer subunit gamma-2 20 GANAB_MOUSE Isoform 2 of Neutral alpha-glucosidase AB 20 SMCA5_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily20 A member 5 RL6_MOUSE 60S ribosomal protein L6 20 ACDSB_MOUSE Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial 20 CSN2_MOUSE COP9 signalosome complex subunit 2 20 VPS35_MOUSE Vacuolar protein sorting-associated protein 35 20 PSD11_MOUSE 26S proteasome non-ATPase regulatory subunit 11 20 DHB12_MOUSE Estradiol 17-beta-dehydrogenase 12 20 D3Z158_MOUSE Protein Qars 20 A2AFQ2_MOUSE 3-hydroxyacyl-CoA dehydrogenase type-2 20 EZRI_MOUSE Ezrin 20 PSA2_MOUSE Proteasome subunit alpha type-2 20 Q3U422_MOUSE NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 20 DEST_MOUSE Destrin 20 SFXN1_MOUSE Sideroflexin-1 20 CAP1_MOUSE Adenylyl cyclase-associated protein 1 20 RRFM_MOUSE Ribosome-recycling factor, mitochondrial 20 SPB6_MOUSE Serpin B6 20 NIT2_MOUSE Omega-amidase NIT2 20 E9Q3G8_MOUSE Protein Nup153 20 ODBB_MOUSE 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 20 E9Q740_MOUSE Signal recognition particle subunit SRP72 20 TOP1_MOUSE DNA topoisomerase 1 20 VDAC3_MOUSE Voltage-dependent anion-selective channel protein 3 20 TXNL1_MOUSE Thioredoxin-like protein 1 20 F7B5B5_MOUSE Protein Hnrnpr 20 E9PYB0_MOUSE Protein Ahnak2 (Fragment) 20 SHLB2_MOUSE Endophilin-B2 20 PSME1_MOUSE Proteasome activator complex subunit 1 20 EPS15_MOUSE Epidermal growth factor receptor substrate 15 20 ITSN1_MOUSE Intersectin-1 20 MLEC_MOUSE Malectin 20 EIF3H_MOUSE Eukaryotic translation initiation factor 3 subunit H 20 E9Q512_MOUSE Protein Trip11 20 RS13_MOUSE 40S ribosomal protein S13 19 VAPB_MOUSE Vesicle-associated membrane protein-associated protein B 19 GDIR2_MOUSE Rho GDP-dissociation inhibitor 2 19 AOFA_MOUSE Amine oxidase [flavin-containing] A 19 CKAP5_MOUSE Cytoskeleton-associated protein 5 19 RU2A_MOUSE U2 small nuclear ribonucleoprotein A' 19 Q9CZN7_MOUSE Serine hydroxymethyltransferase 19 XPO2_MOUSE Exportin-2 19 CHD4_MOUSE Chromodomain-helicase-DNA-binding protein 4 19 IDI1_MOUSE Isopentenyl-diphosphate Delta-isomerase 1 19 HSDL2_MOUSE Hydroxysteroid dehydrogenase-like protein 2 19 PSMD7_MOUSE 26S proteasome non-ATPase regulatory subunit 7 19 THIO_MOUSE Thioredoxin 19 KAPCA_MOUSE cAMP-dependent protein kinase catalytic subunit alpha 19 IF4G2_MOUSE Eukaryotic translation initiation factor 4 gamma 2 19 IF2B1_MOUSE Insulin-like growth factor 2 mRNA-binding protein 1 19 DDX1_MOUSE ATP-dependent RNA helicase DDX1 19 E9Q7G0_MOUSE Protein Numa1 19 SET_MOUSE Protein SET 19 GTF2I_MOUSE General transcription factor II-I 19 PLOD1_MOUSE Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 19 ODPA_MOUSE Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 19 NAA15_MOUSE N-alpha-acetyltransferase 15, NatA auxiliary subunit 19
EP
Akap12 Vps13a Col6a1 Uba2 Copg2 Ganab Smarca5 Rpl6 Acadsb Cops2 Vps35 Psmd11 Hsd17b12 Qars Hsd17b10 Ezr Psma2 Ndufv3 Dstn Sfxn1 Cap1 Mrrf Serpinb6 Nit2 Nup153 Bckdhb Srp72 Top1 Vdac3 Txnl1 Hnrnpr Ahnak2 Sh3glb2 Psme1 Eps15 Itsn1 Mlec Eif3h Trip11 Rps13 Vapb Arhgdib Maoa Ckap5 Snrpa1 Shmt2 Cse1l Chd4 Idi1 Hsdl2 Psmd7 Txn Prkaca Eif4g2 Igf2bp1 Ddx1 Numa1 Set Gtf2i Plod1 Pdha1 Naa15
AC C
sp|Q9WTQ5|AKA12_MOUSE sp|Q5H8C4|VP13A_MOUSE sp|Q04857|CO6A1_MOUSE sp|Q9Z1F9|SAE2_MOUSE sp|Q9QXK3|COPG2_MOUSE sp|Q8BHN3-2|GANAB_MOUSE sp|Q91ZW3|SMCA5_MOUSE sp|P47911|RL6_MOUSE sp|Q9DBL1|ACDSB_MOUSE sp|P61202|CSN2_MOUSE sp|Q9EQH3|VPS35_MOUSE sp|Q8BG32|PSD11_MOUSE sp|O70503|DHB12_MOUSE tr|D3Z158|D3Z158_MOUSE tr|A2AFQ2|A2AFQ2_MOUSE sp|P26040|EZRI_MOUSE sp|P49722|PSA2_MOUSE tr|Q3U422|Q3U422_MOUSE sp|Q9R0P5|DEST_MOUSE sp|Q99JR1|SFXN1_MOUSE sp|P40124|CAP1_MOUSE sp|Q9D6S7|RRFM_MOUSE sp|Q60854|SPB6_MOUSE sp|Q9JHW2|NIT2_MOUSE tr|E9Q3G8|E9Q3G8_MOUSE sp|Q6P3A8|ODBB_MOUSE tr|E9Q740|E9Q740_MOUSE sp|Q04750|TOP1_MOUSE sp|Q60931|VDAC3_MOUSE sp|Q8CDN6|TXNL1_MOUSE tr|F7B5B5|F7B5B5_MOUSE tr|E9PYB0|E9PYB0_MOUSE sp|Q8R3V5|SHLB2_MOUSE sp|P97371|PSME1_MOUSE sp|P42567|EPS15_MOUSE sp|Q9Z0R4|ITSN1_MOUSE sp|Q6ZQI3|MLEC_MOUSE sp|Q91WK2|EIF3H_MOUSE tr|E9Q512|E9Q512_MOUSE sp|P62301|RS13_MOUSE sp|Q9QY76|VAPB_MOUSE sp|Q61599|GDIR2_MOUSE sp|Q64133|AOFA_MOUSE sp|A2AGT5|CKAP5_MOUSE sp|P57784|RU2A_MOUSE tr|Q9CZN7|Q9CZN7_MOUSE sp|Q9ERK4|XPO2_MOUSE sp|Q6PDQ2|CHD4_MOUSE sp|P58044|IDI1_MOUSE sp|Q2TPA8|HSDL2_MOUSE sp|P26516|PSMD7_MOUSE sp|P10639|THIO_MOUSE sp|P05132|KAPCA_MOUSE sp|Q62448|IF4G2_MOUSE sp|O88477|IF2B1_MOUSE sp|Q91VR5|DDX1_MOUSE tr|E9Q7G0|E9Q7G0_MOUSE sp|Q9EQU5|SET_MOUSE sp|Q9ESZ8|GTF2I_MOUSE sp|Q9R0E2|PLOD1_MOUSE sp|P35486|ODPA_MOUSE sp|Q80UM3|NAA15_MOUSE
971.518 1220.86 956.563 979.727 986.097 1355.3 916.569 1155.38 957.132 959.037 1322.39 789.129 1150.58 837.831 877.37 1274.32 1004.56 1574.89 683.601 931.869 879.545 760.234 945.223 867.485 697.985 869.175 683.145 1343.14 727.577 1300.63 987.018 1045.13 1038.85 1188.74 942.245 844.773 1128.2 992.045 855.561 1036.4 742.744 1514.29 1075.52 1004.41 782.943 961.497 1182.84 1033.08 1423.35 807.737 792.964 689.885 1217.72 813.606 921.027 758.568 762.174 1345.19 816.142 976.556 594.886 1307.7
346.827 876.242 493.655 1316.07 1735.24 1223.78 620.079 875.248 783.656 1180.98 1379.47 871.604 1966.31 1004.37 1592.63 1459.45 1107.21 647.434 1480.92 1348.66 1352.58 676.387 1317.98 595.597 793.101 1500.53 1690.15 1037.96 2976.67 1752.03 765.042 426.734 564.526 1177.32 964.957 872.484 1400.85 1133.32 986.734 1199.98 1089.1 1564.29 1531.97 1177.58 987.098 1397.75 1326.83 1006.39 542.772 681.242 1065.76 1803.34 1282.59 1589.2 1023.34 1023.09 1312.48 1035.25 675.145 926.856 1530.25 1215.45
1246.02 818.137 468.995 1550.29 1474.51 1024.7 343.556 842.966 925.816 887.907 848.022 711.179 1549.45 903.324 1778.19 1473.71 1139.55 1646.25 3875.34 1005.6 1721.9 1634.21 1023.45 1120.88 1398.41 2486.54 1402.86 738.168 643.603 3146.5 1155.21 726.981 1192.71 1650.55 1275.17 1487.93 1626.96 932.465 1654.58 729.345 2483.71 2279.79 936.615 1027.66 1406.21 951.267 965.798 1058.25 883.046 1461.63 785.802 4058.57 1283.96 1282.4 1373.49 1123.36 1724.04 1515.43 1124.42 420.557 3228.53 1016.2
1.23 1.21 1.17 1.16 1.16 1.15 1.14 1.12 1.11 1.11 1.11 1.09 1.07 1.06 1.04 1.00 1.00 1.00 1.00 0.99 0.98 0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.94 0.93 0.91 0.89 0.88 0.87 0.87 0.86 0.83 0.80 0.74 1.54 1.34 1.33 1.32 1.27 1.26 1.22 1.22 1.21 1.20 1.17 1.15 1.14 1.13 1.12 1.09 1.09 1.09 1.07 1.06 1.05 1.04 1.03
0.99 0.77 0.51 1.50 1.59 0.91 0.54 0.77 0.97 1.05 0.84 1.00 1.68 1.08 1.78 1.18 0.98 0.69 3.73 1.03 1.59 1.30 1.16 0.91 1.31 2.19 1.91 0.57 2.17 1.77 0.81 0.44 0.69 0.91 0.94 1.08 1.18 0.78 1.02 1.12 2.53 1.67 1.46 1.19 1.67 1.28 1.21 1.24 0.63 1.40 1.14 5.15 1.11 1.86 1.32 1.30 1.95 1.09 0.99 0.63 3.64 0.91
ACCEPTED MANUSCRIPT
TE D
1382.98 1011.31 594.529 1042.44 1013.14 1587.51 1044.2 1421.57 1138.96 1292.88 635.649 1134.34 689.8 880.916 1212.16 1059.76 1034.4 1159.57 465.18 936.166 670.12 1008.26 456.962 891.561 656.068 785.824 596.17 965.669 1320.45 988.823 717.187 1050.51 678.873 658.175 641.008 667.898 1042.32 921.957 1297.51 923.892 1217.48 1460.28 1504.02 876.504 659.382 1172.54 923.192 824.772 616.96 1038.73 940.864 1137.98 703.792 997.116 866.033 390.1 854.442 598.589 486.635 573.853 756.136 694.183
1295.97 1360.63 845.447 1120.92 1194.28 1221.06 1082.77 1167.89 1212.92 1293.39 660.49 1115.33 698.252 787.015 949.946 1125.16 867.228 1959.94 898.381 1402.21 1139.37 1547.58 575.264 1186.64 815.019 1212.91 891.288 915.68 1533.8 1213.46 776.141 1260.83 862.873 823.174 841.817 791.487 1246.36 825.338 1066.42 1018.66 1398.58 1365.13 1322.61 944.579 612.225 1184.78 834.8 942.976 715.692 1019.43 920.219 1224.52 631.105 858.21 747.21 1589.35 1003.54 1010.14 779.686 658.141 1104 1153.85
RI PT
1193.34 1215.82 787.73 1044.5 1188.47 1193.09 968.918 1187.47 1227.1 1347.89 691.287 1523.7 810.028 1011.83 812.489 1198.11 897.347 958.005 519.632 993.015 846.016 1163.84 397.067 1017.61 619.014 970.824 747.425 813.97 1300.78 1138.84 698.338 1066.11 797.578 707.015 709.193 648.968 1198.63 756.704 1113.32 956.13 1172.74 1181.7 1224.6 906.448 743.112 1330.02 757.923 1001.5 769.192 924.374 987.151 1435.24 690.011 865.397 893.547 915.845 652.231 660.28 511.771 560.944 913.813 925.765
SC
19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 17 17 17 17 17 17 17
M AN U
NPC2_MOUSE Epididymal secretory protein E1 RAN_MOUSE GTP-binding nuclear protein Ran BPHL_MOUSE Valacyclovir hydrolase ZN638_MOUSE Zinc finger protein 638 FCL_MOUSE GDP-L-fucose synthase CAPR1_MOUSE Caprin-1 CE170_MOUSE Centrosomal protein of 170 kDa RL27A_MOUSE 60S ribosomal protein L27a NDUA5_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 PRDX3_MOUSE Thioredoxin-dependent peroxide reductase, mitochondrial STML2_MOUSE Stomatin-like protein 2, mitochondrial ATP5I_MOUSE ATP synthase subunit e, mitochondrial CSN4_MOUSE COP9 signalosome complex subunit 4 RL32_MOUSE 60S ribosomal protein L32 CDC37_MOUSE Hsp90 co-chaperone Cdc37 H3BL37_MOUSE Treacle protein TB182_MOUSE 182 kDa tankyrase-1-binding protein ATP5L_MOUSE ATP synthase subunit g, mitochondrial LIPS_MOUSE Hormone-sensitive lipase PEPL1_MOUSE Probable aminopeptidase NPEPL1 TRNT1_MOUSE CCA tRNA nucleotidyltransferase 1, mitochondrial ITB1_MOUSE Integrin beta-1 TAGL2_MOUSE Transgelin-2 MA2A1_MOUSE Alpha-mannosidase 2 TIM13_MOUSE Mitochondrial import inner membrane translocase subunit Tim13 MUC18_MOUSE Cell surface glycoprotein MUC18 SYCC_MOUSE Cysteine--tRNA ligase, cytoplasmic RS16_MOUSE 40S ribosomal protein S16 GYS1_MOUSE Glycogen [starch] synthase, muscle ACOX3_MOUSE Peroxisomal acyl-coenzyme A oxidase 3 GUAA_MOUSE GMP synthase [glutamine-hydrolyzing] ERP44_MOUSE Endoplasmic reticulum resident protein 44 RADI_MOUSE Radixin DC1L1_MOUSE Cytoplasmic dynein 1 light intermediate chain 1 C1TM_MOUSE Monofunctional C1-tetrahydrofolate synthase, mitochondrial HMGB2_MOUSE High mobility group protein B2 NDUAA_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial SF01_MOUSE Splicing factor 1 RL24_MOUSE 60S ribosomal protein L24 SLK_MOUSE STE20-like serine/threonine-protein kinase KAD3_MOUSE GTP:AMP phosphotransferase AK3, mitochondrial FKBP3_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP3 EIF3G_MOUSE Eukaryotic translation initiation factor 3 subunit G FMR1_MOUSE Fragile X mental retardation protein 1 homolog CPNS1_MOUSE Calpain small subunit 1 DHI1_MOUSE Corticosteroid 11-beta-dehydrogenase isozyme 1 NSF1C_MOUSE NSFL1 cofactor p47 SNX2_MOUSE Sorting nexin-2 TMLH_MOUSE Trimethyllysine dioxygenase, mitochondrial MESD_MOUSE LDLR chaperone MESD TCRG1_MOUSE Transcription elongation regulator 1 STA5A_MOUSE Signal transducer and activator of transcription 5A BLVRB_MOUSE Flavin reductase (NADPH) GOGA2_MOUSE Golgin subfamily A member 2 COR1B_MOUSE Coronin-1B CO1A2_MOUSE Collagen alpha-2(I) chain SRRM2_MOUSE Serine/arginine repetitive matrix protein 2 RAC1_MOUSE Ras-related C3 botulinum toxin substrate 1 VAPA_MOUSE Vesicle-associated membrane protein-associated protein A AP2A2_MOUSE AP-2 complex subunit alpha-2 DHX9_MOUSE Isoform 2 of ATP-dependent RNA helicase A VWA8_MOUSE von Willebrand factor A domain-containing protein 8
EP
Npc2 Ran Bphl Znf638 Tsta3 Caprin1 Cep170 Rpl27a Ndufa5 Prdx3 Stoml2 Atp5i Cops4 Rpl32 Cdc37 Tcof1 Tnks1bp1 Atp5l Lipe Npepl1 Trnt1 Itgb1 Tagln2 Man2a1 Timm13 Mcam Cars Rps16 Gys1 Acox3 Gmps Erp44 Rdx Dync1li1 Mthfd1l Hmgb2 Ndufa10 Sf1 Rpl24 Slk Ak3 Fkbp3 Eif3g Fmr1 Capns1 Hsd11b1 Nsfl1c Snx2 Tmlhe Mesdc2 Tcerg1 Stat5a Blvrb Golga2 Coro1b Col1a2 Srrm2 Rac1 Vapa Ap2a2 Dhx9 Vwa8
AC C
sp|Q9Z0J0|NPC2_MOUSE sp|P62827|RAN_MOUSE sp|Q8R164|BPHL_MOUSE sp|Q61464|ZN638_MOUSE sp|P23591|FCL_MOUSE sp|Q60865|CAPR1_MOUSE sp|Q6A065|CE170_MOUSE sp|P14115|RL27A_MOUSE sp|Q9CPP6|NDUA5_MOUSE sp|P20108|PRDX3_MOUSE sp|Q99JB2|STML2_MOUSE sp|Q06185|ATP5I_MOUSE sp|O88544|CSN4_MOUSE sp|P62911|RL32_MOUSE sp|Q61081|CDC37_MOUSE tr|H3BL37|H3BL37_MOUSE sp|P58871|TB182_MOUSE sp|Q9CPQ8|ATP5L_MOUSE sp|P54310|LIPS_MOUSE sp|Q6NSR8|PEPL1_MOUSE sp|Q8K1J6|TRNT1_MOUSE sp|P09055|ITB1_MOUSE sp|Q9WVA4|TAGL2_MOUSE sp|P27046|MA2A1_MOUSE sp|P62075|TIM13_MOUSE sp|Q8R2Y2|MUC18_MOUSE sp|Q9ER72|SYCC_MOUSE sp|P14131|RS16_MOUSE sp|Q9Z1E4|GYS1_MOUSE sp|Q9EPL9|ACOX3_MOUSE sp|Q3THK7|GUAA_MOUSE sp|Q9D1Q6|ERP44_MOUSE sp|P26043|RADI_MOUSE sp|Q8R1Q8|DC1L1_MOUSE sp|Q3V3R1|C1TM_MOUSE sp|P30681|HMGB2_MOUSE sp|Q99LC3|NDUAA_MOUSE sp|Q64213|SF01_MOUSE sp|Q8BP67|RL24_MOUSE sp|O54988|SLK_MOUSE sp|Q9WTP7|KAD3_MOUSE sp|Q62446|FKBP3_MOUSE sp|Q9Z1D1|EIF3G_MOUSE sp|P35922|FMR1_MOUSE sp|O88456|CPNS1_MOUSE sp|P50172|DHI1_MOUSE sp|Q9CZ44|NSF1C_MOUSE sp|Q9CWK8|SNX2_MOUSE sp|Q91ZE0|TMLH_MOUSE sp|Q9ERE7|MESD_MOUSE sp|Q8CGF7|TCRG1_MOUSE sp|P42230|STA5A_MOUSE sp|Q923D2|BLVRB_MOUSE sp|Q921M4|GOGA2_MOUSE sp|Q9WUM3|COR1B_MOUSE sp|Q01149|CO1A2_MOUSE sp|Q8BTI8|SRRM2_MOUSE sp|P63001|RAC1_MOUSE sp|Q9WV55|VAPA_MOUSE sp|P17427|AP2A2_MOUSE sp|O70133-2|DHX9_MOUSE sp|Q8CC88|VWA8_MOUSE
1358.49 923.378 548.846 960.769 991.434 1514.16 866.215 1297.51 1020.98 1195.08 582.218 1345.11 681.566 905.979 823.135 822.995 753.678 1447.74 572.522 1304.7 747.768 1124.43 465.376 1075.5 679.84 838.141 658.999 1127.33 1399.14 1109.49 759.195 1011.57 717.636 637.483 597.253 595.785 1110.28 909.296 1382.68 886.012 1018.59 1304.08 1359.53 798.636 744.72 1223.82 777.416 787.551 572.516 786.747 771.833 1009.06 553.95 725.194 738.124 567.481 1116.17 690.373 524.944 792.767 1013.7 856.045
775.025 1684.09 690.853 701.361 1105.64 817.406 1019.94 1374.63 1070.25 1194.11 943.925 887.117 1449.13 1925.57 1004.24 426.895 639.722 1068.68 1164.57 731.985 915.737 1514.29 879.831 1070.16 514.988 456.999 1014.45 1100.19 632.138 1323.41 1750.02 784.225 851.172 828.043 1213.86 1362.4 1056.93 732.34 1399.73 1168.35 878.592 1180.81 1241.23 623.304 1233.57 661.238 677.749 889.271 725.083 1034.5 1009.5 931.323 722.266 668.178 916.455 418.642 596.361 2370.28 1092.87 1076.34 1082.1 694.786
1060.12 1488.74 897.305 1680.86 1074.71 2258.14 1182.6 2482.22 1808.99 1899.56 923.754 1066.68 1242.98 2795.87 1244.57 819.921 1416.31 1007.55 1597.43 947.01 782.09 903.808 1075.03 763.268 1230.75 699.621 610.188 1057.32 491.437 902.706 1668.79 1140.12 690.931 875.263 1064.03 2032 1163.85 1408.42 2673.24 1529.32 1830.31 2095.16 2284.78 784.509 1293.03 532.62 1158.97 872.829 1149.91 1836.44 1203.35 908.728 1591.77 1230.2 1229.1 384.401 1558.54 1553.02 1793.35 1169.57 1295.51 1263.77
1.03 1.03 1.01 1.00 0.99 0.98 0.97 0.94 0.94 0.94 0.94 0.93 0.92 0.89 0.88 0.86 0.84 1.61 1.49 1.40 1.24 1.23 1.22 1.18 1.17 1.17 1.15 1.15 1.12 1.09 1.08 1.07 1.07 1.07 1.07 1.05 1.05 1.03 1.02 1.01 1.01 1.01 0.98 0.98 0.97 0.96 0.96 0.95 0.93 0.92 0.88 0.87 0.85 0.85 0.84 1.65 1.41 1.35 1.31 1.28 1.27 1.24
0.71 1.42 1.15 1.14 0.99 1.11 1.09 1.48 1.22 1.17 1.41 0.74 1.79 2.49 1.11 0.55 1.06 0.98 2.80 0.87 1.12 1.11 2.29 0.96 1.37 0.66 1.21 1.21 0.43 1.05 2.42 0.91 1.04 1.25 1.69 2.58 0.99 1.28 1.69 1.43 1.13 1.24 1.29 0.79 1.80 0.48 1.09 0.96 1.35 1.46 1.15 0.72 1.66 1.02 1.22 0.61 1.43 3.12 2.89 1.98 1.42 1.21
ACCEPTED MANUSCRIPT
778.537 510.883 545.343 853.623 792.179 749.804 917.946 1070.7 1168.53 788.49 563.468 745.125 1070.42 1590.88 515.487 1000.57 967.976 901.779 583.342 927.806 786.131 950.327 706.585 971.109 740.61 1164.21 709.326 871.797 917.125 927.016 994.127 1140.48 726.281 719.339 612.297 832.159 1171.4 690.067 1014.43 1073.51 1421.26 579.089 526.761 781.752 816.2 722.709 484.301 911.235 675.603 933.611 985.128 860.811 804.894 1054.98 668.459 723.116 713.825 648.908 835.46 818.958 646.184 706.208
912.123 720.561 592.101 1131.52 1194.22 985.879 1344.04 1431.78 1378.3 905.876 727.81 980.415 1300.41 1518.46 661.655 1204.5 1104.87 1117.17 721.219 954.09 932.369 989.251 820.498 1123.66 868.651 1060.59 844.882 888.148 1012.16 923.083 887.489 999.76 656.467 744.716 700.612 908.575 1091.95 618.499 902.327 1009.43 615.434 1268.09 860.061 1291.21 948.14 889.846 740.138 1246.75 1078.31 1199.71 1223.84 1203.32 1023.17 1649.77 829.994 965.029 997.033 642.396 1080.36 1036.32 702.119 815.262
RI PT
687.623 517.457 503.566 953.096 975.007 887.045 1216.84 1311.25 1360.39 878.533 612.045 878.26 1190.09 1366.16 654.162 1187.79 997.673 1177.22 770.893 905.837 934.183 930.989 785.983 1114.32 924.713 973.128 854.47 991.893 1007.75 888.734 980.655 1011.15 844.529 735.574 794.413 1015.2 1031.53 666.825 1010.9 1205.38 1716.87 672.282 628.077 916.591 632.54 679.523 584.412 1016 888.808 1017.64 955.653 1010.75 775.762 1168.54 691.919 847.242 853.211 551.416 961.9 918.283 692.834 715.281
SC
17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16
M AN U
TE D
Dpp3 Got1 Ik Ilf3 Nutf2 Matr3 Cryz Psma6 Pdap1 Tns1 Usp47 Pabpc4 Qki Rpl26 Cfl2 Sf3b3 Fam129b Hars Sf3a3 Naca Ssbp1 Pak2 Ca5b Fam213a Papss2 Pon2 Mars Sar1b Rap1a Acta2 Ddx6 Ndufs2 Cul3 Bzw2 Samhd1 Myl12a Psma1 Cops3 Capn1 Psma7 Palm Ptbp1 Afg3l2 Fermt2 Ap2b1
ECM29_MOUSE Proteasome-associated protein ECM29 homolog CY1_MOUSE Cytochrome c1, heme protein, mitochondrial IMB1_MOUSE Importin subunit beta-1 TMX3_MOUSE Protein disulfide-isomerase TMX3 ARLY_MOUSE Argininosuccinate lyase ASSY_MOUSE Argininosuccinate synthase Q921K2_MOUSE Poly (ADP-ribose) polymerase family, member 1 LAMP1_MOUSE Lysosome-associated membrane glycoprotein 1 LKHA4_MOUSE Leukotriene A-4 hydrolase SNAA_MOUSE Alpha-soluble NSF attachment protein PLPL8_MOUSE Calcium-independent phospholipase A2-gamma SEP11_MOUSE Septin-11 PRUNE_MOUSE Protein prune homolog FKB10_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP10 ARP2_MOUSE Actin-related protein 2 PPME1_MOUSE Protein phosphatase methylesterase 1 CN166_MOUSE UPF0568 protein C14orf166 homolog DPP3_MOUSE Dipeptidyl peptidase 3 AATC_MOUSE Aspartate aminotransferase, cytoplasmic RED_MOUSE Protein Red ILF3_MOUSE Interleukin enhancer-binding factor 3 NTF2_MOUSE Nuclear transport factor 2 MATR3_MOUSE Matrin-3 QOR_MOUSE Quinone oxidoreductase PSA6_MOUSE Proteasome subunit alpha type-6 HAP28_MOUSE 28 kDa heat- and acid-stable phosphoprotein E9Q0S6_MOUSE Protein Tns1 UBP47_MOUSE Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 47 A3KFU5_MOUSE Protein Pabpc4 QKI_MOUSE Protein quaking RL26_MOUSE 60S ribosomal protein L26 COF2_MOUSE Cofilin-2 SF3B3_MOUSE Splicing factor 3B subunit 3 NIBL1_MOUSE Niban-like protein 1 SYHC_MOUSE Histidine--tRNA ligase, cytoplasmic SF3A3_MOUSE Splicing factor 3A subunit 3 NACAM_MOUSE Nascent polypeptide-associated complex subunit alpha, muscle-specific form Q8R2K3_MOUSE Single-stranded DNA-binding protein PAK2_MOUSE Serine/threonine-protein kinase PAK 2 CAH5B_MOUSE Carbonic anhydrase 5B, mitochondrial F213A_MOUSE Redox-regulatory protein FAM213A PAPS2_MOUSE Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 PON2_MOUSE Serum paraoxonase/arylesterase 2 SYMC_MOUSE Methionine--tRNA ligase, cytoplasmic SAR1B_MOUSE GTP-binding protein SAR1b RAP1A_MOUSE Ras-related protein Rap-1A ACTA_MOUSE Actin, aortic smooth muscle DDX6_MOUSE Probable ATP-dependent RNA helicase DDX6 NDUS2_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial CUL3_MOUSE Cullin-3 BZW2_MOUSE Basic leucine zipper and W2 domain-containing protein 2 SAMH1_MOUSE Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q6ZWQ9_MOUSE MCG5400 PSA1_MOUSE Proteasome subunit alpha type-1 CSN3_MOUSE COP9 signalosome complex subunit 3 CAN1_MOUSE Calpain-1 catalytic subunit PSA7_MOUSE Proteasome subunit alpha type-7 PALM_MOUSE Paralemmin-1 Q8BGJ5_MOUSE MCG13402, isoform CRA_a AFG32_MOUSE AFG3-like protein 2 FERM2_MOUSE Fermitin family homolog 2 AP2B1_MOUSE AP-2 complex subunit beta
EP
Ecm29 Cyc1 Kpnb1 Tmx3 Asl Ass1 Parp1 Lamp1 Lta4h Napa Pnpla8 septin11 Prune Fkbp10 Actr2 Ppme1
AC C
sp|Q6PDI5|ECM29_MOUSE sp|Q9D0M3|CY1_MOUSE sp|P70168|IMB1_MOUSE sp|Q8BXZ1|TMX3_MOUSE sp|Q91YI0|ARLY_MOUSE sp|P16460|ASSY_MOUSE tr|Q921K2|Q921K2_MOUSE sp|P11438|LAMP1_MOUSE sp|P24527|LKHA4_MOUSE sp|Q9DB05|SNAA_MOUSE sp|Q8K1N1|PLPL8_MOUSE sp|Q8C1B7|SEP11_MOUSE sp|Q8BIW1|PRUNE_MOUSE sp|Q61576|FKB10_MOUSE sp|P61161|ARP2_MOUSE sp|Q8BVQ5|PPME1_MOUSE sp|Q9CQE8|CN166_MOUSE sp|Q99KK7|DPP3_MOUSE sp|P05201|AATC_MOUSE sp|Q9Z1M8|RED_MOUSE sp|Q9Z1X4|ILF3_MOUSE sp|P61971|NTF2_MOUSE sp|Q8K310|MATR3_MOUSE sp|P47199|QOR_MOUSE sp|Q9QUM9|PSA6_MOUSE sp|Q3UHX2|HAP28_MOUSE tr|E9Q0S6|E9Q0S6_MOUSE sp|Q8BY87-2|UBP47_MOUSE tr|A3KFU5|A3KFU5_MOUSE sp|Q9QYS9|QKI_MOUSE sp|P61255|RL26_MOUSE sp|P45591|COF2_MOUSE sp|Q921M3|SF3B3_MOUSE sp|Q8R1F1|NIBL1_MOUSE sp|Q61035|SYHC_MOUSE sp|Q9D554|SF3A3_MOUSE sp|P70670|NACAM_MOUSE tr|Q8R2K3|Q8R2K3_MOUSE sp|Q8CIN4|PAK2_MOUSE sp|Q9QZA0|CAH5B_MOUSE sp|Q9CYH2|F213A_MOUSE sp|O88428|PAPS2_MOUSE sp|Q62086|PON2_MOUSE sp|Q68FL6|SYMC_MOUSE sp|Q9CQC9|SAR1B_MOUSE sp|P62835|RAP1A_MOUSE sp|P62737|ACTA_MOUSE sp|P54823|DDX6_MOUSE sp|Q91WD5|NDUS2_MOUSE sp|Q9JLV5|CUL3_MOUSE sp|Q91VK1|BZW2_MOUSE sp|Q60710|SAMH1_MOUSE tr|Q6ZWQ9|Q6ZWQ9_MOUSE sp|Q9R1P4|PSA1_MOUSE sp|O88543|CSN3_MOUSE sp|O35350|CAN1_MOUSE sp|Q9Z2U0|PSA7_MOUSE sp|Q9Z0P4|PALM_MOUSE tr|Q8BGJ5|Q8BGJ5_MOUSE sp|Q8JZQ2|AFG32_MOUSE sp|Q8CIB5|FERM2_MOUSE sp|Q9DBG3|AP2B1_MOUSE
904.729 541.558 644.59 963.919 823.625 867.731 1040.58 1212.83 1418.6 915.423 539.995 758.766 1030.05 1522.6 523.158 988.57 849.461 945.984 621.878 862.704 765.215 859.466 642.744 900.373 742.247 988.925 654.588 889.749 807.543 782.138 962.983 1004.02 798.227 600.953 591.882 751.326 879.798 557.768 839.274 723.767 422.211 888.337 726.491 911.232 922.446 859.732 554.367 1045.68 781.041 1101.12 1059.51 958.991 801.457 897.086 688.244 777.569 715.594 648.427 851.529 822.495 723.579 697.161
1239.25 708.355 1441.34 929.768 881.083 1341.56 785.499 1065.74 1185.44 1223.3 900.782 917.009 1260.62 936.209 798.79 1574.72 1082.44 677.28 1324.02 640.414 950.717 697.435 603.501 775.855 838.983 598.576 643.613 1030.46 600.952 622.053 715.197 1031.75 600.798 1104.64 920.112 1074.56 780.248 630.001 903.916 700.839 2552.79 692.874 534.221 1042.38 792.554 1461.34 538.813 945.139 878.931 1150.56 1290.09 1102.71 868.077 1055.53 1417.7 1093.27 855.416 503.501 933.312 708.192 935.296 929.743
950.492 700.055 783.877 611.538 559.882 989.763 924.858 934.565 1015.18 1229.75 997.97 945.719 1306.6 1203.67 560.88 1558.42 1233.68 759.798 873.144 1016.27 1169.64 1275.42 1003.2 1362.91 765.161 1211.02 1191.63 1277.37 1172.58 1233.24 1251.51 2055.11 483.191 885.803 802.34 1012.69 1666.07 1080.31 1266.71 1978.86 2416.84 826.261 555.04 829.486 928.931 1263.44 556.508 728.737 731.522 686.294 1346.51 1339.56 1861.19 1267.37 1023.55 845.572 740.551 723.282 925.467 826.105 723.737 1024.61
1.24 1.23 1.18 1.16 1.14 1.13 1.12 1.11 1.11 1.09 1.08 1.07 1.03 1.03 1.01 1.00 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.97 0.97 0.96 0.96 0.95 0.95 0.94 0.94 0.93 0.93 0.92 0.92 0.90 0.90 0.87 0.86 0.76 0.33 1.72 1.37 1.30 1.29 1.25 1.21 1.19 1.19 1.18 1.18 1.16 1.15 1.15 1.12 1.11 1.09 1.08 1.07 1.07 1.06 1.06
1.49 1.37 2.12 0.85 0.82 1.42 0.80 0.84 0.87 1.47 1.62 1.15 1.14 0.72 1.16 1.43 1.18 0.69 1.62 0.90 1.23 1.05 1.08 1.03 0.96 0.85 1.17 1.24 0.92 1.02 1.00 1.43 0.69 1.37 1.22 1.13 1.11 1.26 1.07 1.18 1.58 1.21 0.94 1.10 1.19 1.94 1.02 0.87 1.03 0.94 1.36 1.30 1.73 1.04 1.79 1.23 1.02 1.02 1.03 0.88 1.24 1.37
ACCEPTED MANUSCRIPT
TE D
1027.52 491.497 940.919 1048.72 554.458 683.602 817.329 630.732 793.348 852.656 934.437 1343.61 553.135 783.483 706.87 735.764 515.732 944.108 1026.16 723.08 865.728 716.091 798.664 1050.28 647.84 888.782 793.263 1018.31 908.82 913.95 840.291 953.684 420.311 587.054 502.144 807.717 991.172 928.478 706.228 807.231 644.843 599.813 723.416 581.113 550.929 845.671 763.739 715.183 908.613 485.895 720.152 677.401 557.156 743.191 638.037 921.551 713.024 827.342 930.929 569.922 623.689 678.381
1386.3 583.438 782.516 1108.32 677.042 848.708 904.73 749.537 816.244 922.804 974.191 1020.87 612.092 847.894 753.465 908.528 599.259 855.889 989.171 759.632 817.883 873.774 1083.65 785.882 627.6 1008.75 780.538 1084.38 779.659 756.412 1616.95 1465.03 815.939 1028.39 846.307 1263.41 986.596 1124.65 1080.89 1005.9 815.154 778.153 1006.17 736.343 690.942 1087.77 848.927 864.781 925.676 694.12 959.759 886.485 589.287 753.157 778.668 818.165 786.736 756.67 924.843 673.944 772.5 737.624
RI PT
1265.6 468.443 869.134 997.493 590.086 818.575 855.751 686.305 813.072 806.815 885.969 702.655 572.547 715.268 750.933 903.64 633.787 825.29 896.014 819.742 847.647 913.319 1215.63 799.631 685.15 1022 734.963 1425.07 912.217 1024.38 726.667 796.014 482.582 572.032 547.784 894.226 840.362 898.925 833.3 886.629 679.227 648.136 787.762 604.974 574.203 931.009 660.315 716.259 777.049 559.713 873.611 781.059 480.526 637.845 676.879 892.624 798.406 648.951 911.416 609.781 734.629 769.602
SC
16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15
M AN U
YMEL1_MOUSE ATP-dependent zinc metalloprotease YME1L1 ATPD_MOUSE ATP synthase subunit delta, mitochondrial ABCD3_MOUSE ATP-binding cassette sub-family D member 3 RT31_MOUSE 28S ribosomal protein S31, mitochondrial TPD54_MOUSE Tumor protein D54 ESYT1_MOUSE Extended synaptotagmin-1 PDXD1_MOUSE Pyridoxal-dependent decarboxylase domain-containing protein 1 HMGB3_MOUSE High mobility group protein B3 ARPC2_MOUSE Actin-related protein 2/3 complex subunit 2 AAKB1_MOUSE 5'-AMP-activated protein kinase subunit beta-1 LZTL1_MOUSE Leucine zipper transcription factor-like protein 1 H2B1M_MOUSE Histone H2B type 1-M CHCH3_MOUSE Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial F162A_MOUSE Protein FAM162A RL22_MOUSE 60S ribosomal protein L22 ROCK2_MOUSE Rho-associated protein kinase 2 MTX2_MOUSE Metaxin-2 PFD5_MOUSE Prefoldin subunit 5 EI3JA_MOUSE Eukaryotic translation initiation factor 3 subunit J-A OXSR1_MOUSE Serine/threonine-protein kinase OSR1 ANXA4_MOUSE Annexin A4 APEH_MOUSE Acylamino-acid-releasing enzyme BGLR_MOUSE Beta-glucuronidase TR150_MOUSE Thyroid hormone receptor-associated protein 3 PIPNB_MOUSE Phosphatidylinositol transfer protein beta isoform PPGB_MOUSE Lysosomal protective protein BT3L4_MOUSE Transcription factor BTF3 homolog 4 MA2B1_MOUSE Lysosomal alpha-mannosidase PPM1G_MOUSE Protein phosphatase 1G GPAT3_MOUSE Glycerol-3-phosphate acyltransferase 3 GSTM2_MOUSE Glutathione S-transferase Mu 2 D3Z6I7_MOUSE Protein Cald1 AT1A1_MOUSE Sodium/potassium-transporting ATPase subunit alpha-1 TPM1_MOUSE Tropomyosin alpha-1 chain SEC63_MOUSE Translocation protein SEC63 homolog CUL4B_MOUSE Cullin-4B IPO5_MOUSE Importin-5 CP51A_MOUSE Lanosterol 14-alpha demethylase IDE_MOUSE Insulin-degrading enzyme UGDH_MOUSE UDP-glucose 6-dehydrogenase AP3B1_MOUSE AP-3 complex subunit beta-1 BASI_MOUSE Basigin K6PL_MOUSE 6-phosphofructokinase, liver type RL14_MOUSE 60S ribosomal protein L14 TNPO1_MOUSE Transportin-1 CUL4A_MOUSE Cullin-4A EM55_MOUSE 55 kDa erythrocyte membrane protein ACTZ_MOUSE Alpha-centractin LASP1_MOUSE LIM and SH3 domain protein 1 PGRC2_MOUSE Membrane-associated progesterone receptor component 2 RAGP1_MOUSE Ran GTPase-activating protein 1 P5CS_MOUSE Delta-1-pyrroline-5-carboxylate synthase NDKA_MOUSE Nucleoside diphosphate kinase A RCN2_MOUSE Reticulocalbin-2 GCP60_MOUSE Golgi resident protein GCP60 RS9_MOUSE 40S ribosomal protein S9 EIF3E_MOUSE Eukaryotic translation initiation factor 3 subunit E UBP2L_MOUSE Ubiquitin-associated protein 2-like NNRE_MOUSE NAD(P)H-hydrate epimerase LMAN1_MOUSE Protein ERGIC-53 PTN11_MOUSE Tyrosine-protein phosphatase non-receptor type 11 ATG7_MOUSE Ubiquitin-like modifier-activating enzyme ATG7
EP
Yme1l1 Atp5d Abcd3 Mrps31 Tpd52l2 Esyt1 Pdxdc1 Hmgb3 Arpc2 Prkab1 Lztfl1 Hist1h2bm Chchd3 Fam162a Rpl22 Rock2 Mtx2 Pfdn5 Eif3j1 Oxsr1 Anxa4 Apeh Gusb Thrap3 Pitpnb Ctsa Btf3l4 Man2b1 Ppm1g Agpat9 Gstm2 Cald1 Atp1a1 Tpm1 Sec63 Cul4b Ipo5 Cyp51a1 Ide Ugdh Ap3b1 Bsg Pfkl Rpl14 Tnpo1 Cul4a Mpp1 Actr1a Lasp1 Pgrmc2 Rangap1 Aldh18a1 Nme1 Rcn2 Acbd3 Rps9 Eif3e Ubap2l Apoa1bp Lman1 Ptpn11 Atg7
AC C
sp|O88967|YMEL1_MOUSE sp|Q9D3D9|ATPD_MOUSE sp|P55096|ABCD3_MOUSE sp|Q61733|RT31_MOUSE sp|Q9CYZ2|TPD54_MOUSE sp|Q3U7R1|ESYT1_MOUSE sp|Q99K01|PDXD1_MOUSE sp|O54879|HMGB3_MOUSE sp|Q9CVB6|ARPC2_MOUSE sp|Q9R078|AAKB1_MOUSE sp|Q9JHQ5|LZTL1_MOUSE sp|P10854|H2B1M_MOUSE sp|Q9CRB9|CHCH3_MOUSE sp|Q9D6U8|F162A_MOUSE sp|P67984|RL22_MOUSE sp|P70336|ROCK2_MOUSE sp|O88441|MTX2_MOUSE sp|Q9WU28|PFD5_MOUSE sp|Q3UGC7|EI3JA_MOUSE sp|Q6P9R2|OXSR1_MOUSE sp|P97429|ANXA4_MOUSE sp|Q8R146|APEH_MOUSE sp|P12265|BGLR_MOUSE sp|Q569Z6|TR150_MOUSE sp|P53811|PIPNB_MOUSE sp|P16675|PPGB_MOUSE sp|Q9CQH7|BT3L4_MOUSE sp|O09159|MA2B1_MOUSE sp|Q61074|PPM1G_MOUSE sp|Q8C0N2|GPAT3_MOUSE sp|P15626|GSTM2_MOUSE tr|D3Z6I7|D3Z6I7_MOUSE sp|Q8VDN2|AT1A1_MOUSE sp|P58771|TPM1_MOUSE sp|Q8VHE0|SEC63_MOUSE sp|A2A432|CUL4B_MOUSE sp|Q8BKC5|IPO5_MOUSE sp|Q8K0C4|CP51A_MOUSE sp|Q9JHR7|IDE_MOUSE sp|O70475|UGDH_MOUSE sp|Q9Z1T1|AP3B1_MOUSE sp|P18572|BASI_MOUSE sp|P12382|K6PL_MOUSE sp|Q9CR57|RL14_MOUSE sp|Q8BFY9|TNPO1_MOUSE sp|Q3TCH7|CUL4A_MOUSE sp|P70290|EM55_MOUSE sp|P61164|ACTZ_MOUSE sp|Q61792|LASP1_MOUSE sp|Q80UU9|PGRC2_MOUSE sp|P46061|RAGP1_MOUSE sp|Q9Z110|P5CS_MOUSE sp|P15532|NDKA_MOUSE sp|Q8BP92|RCN2_MOUSE sp|Q8BMP6|GCP60_MOUSE sp|Q6ZWN5|RS9_MOUSE sp|P60229|EIF3E_MOUSE sp|Q80X50|UBP2L_MOUSE sp|Q8K4Z3|NNRE_MOUSE sp|Q9D0F3|LMAN1_MOUSE sp|P35235|PTN11_MOUSE sp|Q9D906|ATG7_MOUSE
1051.62 435.976 1136.89 1055.3 504.336 701.337 788.734 572.298 795.401 732.754 831.896 1002.09 499.979 631.894 676.407 695.161 515.538 856.779 842.158 701.951 803.527 631.869 763.636 908.675 577.598 706.952 589.85 922.979 664.343 689.534 1186.33 1473.52 591.801 760.633 676.661 974.392 1216.24 1071.04 754.86 1011.4 760.914 689.325 728.446 612.044 587.993 923.452 760.773 744.353 964.326 475.113 783.937 688.693 520.326 710.249 609.146 1081.58 771.06 756.268 936.165 508.603 578.72 699.461
454.75 331.402 1706.27 369.056 392.641 912.479 1284.44 913.819 1407.06 743.234 658.44 1436.98 1018.78 1119.73 1137.76 1200.98 1388.15 991.989 1050.12 781.962 943.332 775.478 788.44 455.377 1063.3 471.994 490.773 575.961 785.987 654.29 1019.8 1138.24 1755.95 816.589 767.375 1804.65 1714.01 279.629 610.455 2477.9 836.649 1355.61 1338.19 2970.15 1564.39 880.235 562.345 1018.09 492.682 568.064 2043.42 1026.63 571.181 486.624 646.332 892.484 789.948 341.73 1487.4 694.658 882.985 1000.25
707.412 714.816 1168.06 1109.49 766.213 1011.53 1216.39 2044.87 1127.8 1222.49 1197.45 1386.1 1390.16 654.417 1298.92 954.039 995.628 1698.89 1846.52 933.025 596.295 915.576 409.986 1109.99 1178.73 721.787 1324.05 697.182 1606.61 570.981 1228.95 1578.98 906.838 1238.61 1048.67 1314.46 1100.23 367.538 636.461 1333.01 844.126 675.294 1163.17 2255.76 826.555 638.66 1655.84 962.356 760.915 404.345 1859.42 627.676 805.106 1290.22 633.75 671.506 647.388 560.876 2042.89 428.665 878.239 855.092
1.06 1.06 1.06 1.06 1.03 1.03 1.01 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.98 0.98 0.97 0.97 0.95 0.95 0.95 0.92 0.92 0.92 0.90 0.90 0.90 0.82 0.79 0.75 1.79 1.68 1.56 1.54 1.45 1.31 1.20 1.20 1.19 1.19 1.19 1.18 1.15 1.14 1.14 1.13 1.13 1.12 1.12 1.12 1.09 1.08 1.07 1.06 1.06 1.05 1.03 1.02 1.01 1.00 0.99 0.99
0.51 1.09 1.59 0.72 1.01 1.28 1.49 2.25 1.58 1.18 1.02 1.38 2.14 1.18 1.67 1.31 2.07 1.52 1.51 1.11 0.90 1.04 0.59 0.85 1.68 0.62 1.19 0.52 1.31 0.63 1.44 1.55 2.95 1.77 1.73 1.83 1.54 0.35 0.81 2.25 1.27 1.63 1.66 4.41 2.13 0.85 1.56 1.38 0.74 0.93 2.45 1.13 1.33 1.29 0.97 0.86 0.95 0.61 1.92 0.95 1.30 1.28
ACCEPTED MANUSCRIPT
943.197 601.801 745.442 813.434 676.441 863.104 760.086 764.552 1007.96 799.446 1040.8 708.573 617.889 719.749 642.416 843.638 1274.86 1275.49 991.278 727.079 917.948 929.475 859.755 642.019 577.24 823.862 1127 1217 473.121 815.144 793.297 744.593 245.146 558.498 1319.4 334.779 415.292 591.682 545.328 569.5 639.715 671.989 431.493 766.855 618.34 658.5 680.702 559.637 577.392 429.418 392.721 462.347 905.627 468.991 633.211 767.072 876.13 795.678 496.388 1323.79 799.601 728.416
818.829 791.795 714.511 869.36 702.607 796.341 1033.59 821.515 964.604 966.999 984.362 700.408 713.689 718.384 617.061 760.941 1270.87 1046.68 885.815 610.729 917.156 899.815 1011.57 577.099 604.089 810.197 961.282 1067.06 444.208 735.838 738.935 652.593 230.949 491.826 799.958 657.394 731.488 1154.77 758.818 686.982 863.955 844.332 577.381 1202.51 727.056 952.956 518.761 752.057 771.928 443.161 327.151 586.674 1249.72 588.961 979.708 907.603 1246.84 1026.29 548.94 1025.55 868.474 956.274
RI PT
742.721 766.857 730.404 863.823 679.957 849.186 1133.68 849.42 960.134 969.652 862.509 649.647 663.8 670.639 571.396 800.213 1285.78 1081.21 851.01 557.183 878.98 1067.82 1055.36 550.794 705.356 846.205 942.36 1305.05 542.243 885.667 782.612 687.239 308.746 527.914 965.407 279.518 369.507 692.249 478.409 457.207 754.142 579.032 450.725 910.02 587.333 728.764 401.508 556.948 532.464 388.237 216.851 556.471 1159.93 432.847 874.989 682.021 1024.56 863.274 476.71 942.405 657.675 789.22
SC
15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14
M AN U
TE D
PGS1_MOUSE Biglycan CO6A2_MOUSE Collagen alpha-2(VI) chain RSSA_MOUSE 40S ribosomal protein SA CDC5L_MOUSE Cell division cycle 5-like protein STK24_MOUSE Serine/threonine-protein kinase 24 ITPA_MOUSE Inosine triphosphate pyrophosphatase PRP19_MOUSE Pre-mRNA-processing factor 19 PURA2_MOUSE Adenylosuccinate synthetase isozyme 2 SMD2_MOUSE Small nuclear ribonucleoprotein Sm D2 MTAP_MOUSE S-methyl-5'-thioadenosine phosphorylase CD2AP_MOUSE CD2-associated protein TMOD3_MOUSE Tropomodulin-3 CD9_MOUSE CD9 antigen UCHL3_MOUSE Ubiquitin carboxyl-terminal hydrolase isozyme L3 MCFD2_MOUSE Multiple coagulation factor deficiency protein 2 homolog CAZA1_MOUSE F-actin-capping protein subunit alpha-1 RBM39_MOUSE RNA-binding protein 39 DNJA2_MOUSE DnaJ homolog subfamily A member 2 F7AA26_MOUSE Protein Palm2Akap2 (Fragment) DNJA1_MOUSE DnaJ homolog subfamily A member 1 SARNP_MOUSE SAP domain-containing ribonucleoprotein CAPZB_MOUSE F-actin-capping protein subunit beta ACSF2_MOUSE Acyl-CoA synthetase family member 2, mitochondrial DENR_MOUSE Density-regulated protein UBA3_MOUSE NEDD8-activating enzyme E1 catalytic subunit GLO2_MOUSE Hydroxyacylglutathione hydrolase, mitochondrial RLA1_MOUSE 60S acidic ribosomal protein P1 LSM2_MOUSE U6 snRNA-associated Sm-like protein LSm2 PP1A_MOUSE Serine/threonine-protein phosphatase PP1-alpha catalytic subunit DDX42_MOUSE ATP-dependent RNA helicase DDX42 Q99LB4_MOUSE Capping protein (Actin filament), gelsolin-like SRBS1_MOUSE Sorbin and SH3 domain-containing protein 1 ESTD_MOUSE S-formylglutathione hydrolase CBR3_MOUSE Carbonyl reductase [NADPH] 3 CHP1_MOUSE Calcineurin B homologous protein 1 BASP1_MOUSE Brain acid soluble protein 1 ISC2A_MOUSE Isochorismatase domain-containing protein 2A, mitochondrial Q9ESU7_MOUSE Neutral amino acid transporter ASCT2 COX5B_MOUSE Cytochrome c oxidase subunit 5B, mitochondrial RL11_MOUSE 60S ribosomal protein L11 ERAP1_MOUSE Endoplasmic reticulum aminopeptidase 1 PPIC_MOUSE Peptidyl-prolyl cis-trans isomerase C PICAL_MOUSE Phosphatidylinositol-binding clathrin assembly protein E9PUM4_MOUSE Talin-2 BZW1_MOUSE Basic leucine zipper and W2 domain-containing protein 1 E9QNL5_MOUSE Sulfotransferase 1A1 H2A2C_MOUSE Histone H2A type 2-C BIRC6_MOUSE Baculoviral IAP repeat-containing protein 6 SRP54_MOUSE Signal recognition particle 54 kDa protein ODBA_MOUSE 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial HMOX1_MOUSE Heme oxygenase 1 ABHD5_MOUSE 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 BGAL_MOUSE Beta-galactosidase CX6B1_MOUSE Cytochrome c oxidase subunit 6B1 LAMA4_MOUSE Laminin subunit alpha-4 MYL9_MOUSE Myosin regulatory light polypeptide 9 MTP_MOUSE Microsomal triglyceride transfer protein large subunit Q91V89_MOUSE Protein Ppp2r5d PCBP1_MOUSE Poly(rC)-binding protein 1 KAP0_MOUSE cAMP-dependent protein kinase type I-alpha regulatory subunit ES1_MOUSE ES1 protein homolog, mitochondrial MP2K1_MOUSE Dual specificity mitogen-activated protein kinase kinase 1
EP
Bgn Col6a2 Rpsa Cdc5l Stk24 Itpa Prpf19 Adss Snrpd2 Mtap Cd2ap Tmod3 Cd9 Uchl3 Mcfd2 Capza1 Rbm39 Dnaja2 Palm2Akap2 Dnaja1 Sarnp Capzb Acsf2 Denr Uba3 Hagh Rplp1 Lsm2 Ppp1ca Ddx42 Capg Sorbs1 Esd Cbr3 Chp1 Basp1 Isoc2a Slc1a5 Cox5b Rpl11 Erap1 Ppic Picalm Tln2 Bzw1 Sult1a1 Hist2h2ac Birc6 Srp54 Bckdha Hmox1 Abhd5 Glb1 Cox6b1 Lama4 Myl9 Mttp Ppp2r5d Pcbp1 Prkar1a D10Jhu81e Map2k1
AC C
sp|P28653|PGS1_MOUSE sp|Q02788|CO6A2_MOUSE sp|P14206|RSSA_MOUSE sp|Q6A068|CDC5L_MOUSE sp|Q99KH8|STK24_MOUSE sp|Q9D892|ITPA_MOUSE sp|Q99KP6|PRP19_MOUSE sp|P46664|PURA2_MOUSE sp|P62317|SMD2_MOUSE sp|Q9CQ65|MTAP_MOUSE sp|Q9JLQ0|CD2AP_MOUSE sp|Q9JHJ0|TMOD3_MOUSE sp|P40240|CD9_MOUSE sp|Q9JKB1|UCHL3_MOUSE sp|Q8K5B2|MCFD2_MOUSE sp|P47753|CAZA1_MOUSE sp|Q8VH51|RBM39_MOUSE sp|Q9QYJ0|DNJA2_MOUSE tr|F7AA26|F7AA26_MOUSE sp|P63037|DNJA1_MOUSE sp|Q9D1J3|SARNP_MOUSE sp|P47757|CAPZB_MOUSE sp|Q8VCW8|ACSF2_MOUSE sp|Q9CQJ6|DENR_MOUSE sp|Q8C878|UBA3_MOUSE sp|Q99KB8|GLO2_MOUSE sp|P47955|RLA1_MOUSE sp|O35900|LSM2_MOUSE sp|P62137|PP1A_MOUSE sp|Q810A7|DDX42_MOUSE tr|Q99LB4|Q99LB4_MOUSE sp|Q62417|SRBS1_MOUSE sp|Q9R0P3|ESTD_MOUSE sp|Q8K354|CBR3_MOUSE sp|P61022|CHP1_MOUSE sp|Q91XV3|BASP1_MOUSE sp|P85094|ISC2A_MOUSE tr|Q9ESU7|Q9ESU7_MOUSE sp|P19536|COX5B_MOUSE sp|Q9CXW4|RL11_MOUSE sp|Q9EQH2|ERAP1_MOUSE sp|P30412|PPIC_MOUSE sp|Q7M6Y3|PICAL_MOUSE tr|E9PUM4|E9PUM4_MOUSE sp|Q9CQC6|BZW1_MOUSE tr|E9QNL5|E9QNL5_MOUSE sp|Q64523|H2A2C_MOUSE sp|O88738|BIRC6_MOUSE sp|P14576|SRP54_MOUSE sp|P50136|ODBA_MOUSE sp|P14901|HMOX1_MOUSE sp|Q9DBL9|ABHD5_MOUSE sp|P23780|BGAL_MOUSE sp|P56391|CX6B1_MOUSE sp|P97927|LAMA4_MOUSE sp|Q9CQ19|MYL9_MOUSE sp|O08601|MTP_MOUSE tr|Q91V89|Q91V89_MOUSE sp|P60335|PCBP1_MOUSE sp|Q9DBC7|KAP0_MOUSE sp|Q9D172|ES1_MOUSE sp|P31938|MP2K1_MOUSE
845.64 551.405 720.792 760.86 612.532 859.993 795.955 729.698 910.139 715.878 819.919 586.328 486.522 574.775 504.469 753.391 1077.17 1112.19 777.11 548.192 700.136 896.639 704.298 490.789 536.774 654.8 830.424 1100.87 424.73 712.275 588.406 519.373 218.442 378.067 850.704 653.807 544.917 925.371 784.285 672.71 946.803 754.907 533.717 900.969 780.857 764.518 820.287 618.423 562.155 537.408 400.733 608.206 1161.62 463.768 775.406 772.311 928.818 868.916 540.327 1510.29 748.081 721.689
513.769 276.108 772.156 776.61 1197.09 1159.85 1100.56 1077.63 872.044 836.834 809.158 560.669 1138.85 874.418 510.901 994.87 1479.16 1258.75 823.698 487.502 590.985 1481.9 636.18 548.251 800.371 657.491 516.615 1274.52 1329.41 879.479 961.248 381.14 1151.74 1650.04 551.824 316.767 439.865 936.449 652.758 807.517 270.647 340.006 427.994 761.955 797.081 219.288 1016.91 816.474 950.562 711.745 1335.08 419.434 767.422 638.181 510.709 732.632 985.107 790.72 595.036 1166.11 1235.71 846.201
1017.36 376.332 740.144 1275.22 1154.3 2402.69 1066.79 1165.09 1558.22 1243.94 1825.15 951.119 666.066 1895.8 1444.82 1403.74 1869.88 2321.2 1545.34 976.869 1051.22 1955.37 3004.49 1280.6 681.229 1733.98 1370.52 1575.35 1443.98 1099.78 1773.47 620.912 1081.85 3101.11 1215.52 638.868 411.771 529.98 1301.68 701.007 432.609 570.228 483.778 791.406 899.706 432.475 1497.46 1188.58 693.483 1365.3 2714.14 496.143 533.207 1181.21 398.519 1521.15 685.767 684.519 932.713 1891.25 3573.94 777.296
0.99 0.98 0.97 0.97 0.97 0.97 0.97 0.96 0.95 0.95 0.95 0.95 0.94 0.93 0.92 0.92 0.92 0.92 0.90 0.90 0.90 0.90 0.90 0.90 0.89 0.88 0.87 0.86 0.86 0.85 0.84 0.82 0.81 0.80 0.72 2.13 1.63 1.62 1.51 1.32 1.30 1.28 1.26 1.25 1.25 1.24 1.24 1.23 1.20 1.20 1.19 1.17 1.17 1.17 1.16 1.16 1.14 1.14 1.12 1.12 1.11 1.11
0.91 0.48 1.02 1.22 1.73 2.08 1.14 1.39 1.23 1.18 1.38 1.11 1.41 1.99 1.61 1.46 1.31 1.52 1.29 1.14 0.91 1.72 1.90 1.53 1.16 1.43 0.91 1.13 2.73 1.16 1.74 0.70 4.03 4.37 0.77 1.56 1.09 1.14 1.91 1.47 0.50 0.73 1.03 0.93 1.41 0.47 2.32 1.80 1.48 2.54 6.64 0.90 0.63 2.02 0.60 1.56 0.88 0.89 1.57 1.35 3.30 1.07
ACCEPTED MANUSCRIPT
584.279 641.52 584.594 520.841 599.106 930.656 693.289 681.321 735.368 485.627 1248.94 1075.51 705.401 673.172 863.177 460.355 846.104 783.466 537.07 554.927 825.526 655.438 621.594 981.642 670.603 508.821 595.318 738.31 1003.41 942.488 1083.13 1158.93 728.361 853.654 720.068 887.687 673.302 814.784 758.358 972.138 381.553 278.343 432.253 561.395 1430.89 657.932 476.959 534.496 428.364 709.297 647.834 571.657 565.918 504.717 481.591 750.287 648.406 840.486 556.235 479.677 444.882 665.276
675.401 816.59 642.518 599.474 756.731 852.751 784.118 837.037 770.309 615.075 849.998 1069.93 738.623 743.55 864.472 475.55 1049.02 840.739 504.25 633.282 816.592 531.14 589.386 991.191 733.718 474.311 692.721 713.774 1153.8 928.279 1057.54 701.415 708.497 958.344 566.28 768.636 612.141 477.741 786.187 816.497 663.81 535.491 743.042 1085.56 1414.42 813.552 803.602 748.021 606.865 1046.47 830.94 779.328 789.189 732.194 530.952 1037.09 957.079 1100.71 768.309 638.004 610.838 833.348
RI PT
595.682 743.103 589.399 528.753 683.525 762.973 780.462 710.537 744.711 621.053 877.856 918.311 737.989 691.57 746.834 456.639 918.955 924.561 505.818 566.849 777.785 672.032 614.616 972.376 723.83 521.584 693.117 723.754 1221.86 1007.18 1036.93 533.554 879.206 1071.33 789.625 833.526 691.743 799.765 993.973 870.245 397.142 330.458 435.892 637.056 1228.03 607.241 578.674 671.209 462.56 819.064 693.304 589.168 570.668 582.095 443.227 945.307 785.567 801.895 648.601 563.214 506.022 626.499
SC
14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
M AN U
TE D
SSRA_MOUSE Translocon-associated protein subunit alpha RM01_MOUSE 39S ribosomal protein L1, mitochondrial CAN2_MOUSE Calpain-2 catalytic subunit DPYL2_MOUSE Dihydropyrimidinase-related protein 2 TMED9_MOUSE Transmembrane emp24 domain-containing protein 9 UBE2N_MOUSE Ubiquitin-conjugating enzyme E2 N CSN1_MOUSE COP9 signalosome complex subunit 1 PROSC_MOUSE Proline synthase co-transcribed bacterial homolog protein PCY2_MOUSE Ethanolamine-phosphate cytidylyltransferase TWF1_MOUSE Twinfilin-1 RL29_MOUSE 60S ribosomal protein L29 DBNL_MOUSE Drebrin-like protein PYRG2_MOUSE CTP synthase 2 BAF_MOUSE Barrier-to-autointegration factor PRC2A_MOUSE Protein PRRC2A HGS_MOUSE Hepatocyte growth factor-regulated tyrosine kinase substrate PSME3_MOUSE Proteasome activator complex subunit 3 UBP7_MOUSE Ubiquitin carboxyl-terminal hydrolase 7 PABP2_MOUSE Polyadenylate-binding protein 2 F1142_MOUSE Isoform 2 of Protein FAM114A2 CATL1_MOUSE Cathepsin L1 AP3D1_MOUSE AP-3 complex subunit delta-1 DDAH1_MOUSE N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 DNJC8_MOUSE DnaJ homolog subfamily C member 8 COQ9_MOUSE Ubiquinone biosynthesis protein COQ9, mitochondrial RS14_MOUSE 40S ribosomal protein S14 IMPA1_MOUSE Inositol monophosphatase 1 PLIN3_MOUSE Perilipin-3 SNX6_MOUSE Sorting nexin-6 MARE1_MOUSE Microtubule-associated protein RP/EB family member 1 EWS_MOUSE RNA-binding protein EWS H14_MOUSE Histone H1.4 CSN5_MOUSE COP9 signalosome complex subunit 5 PLCB3_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 RL30_MOUSE 60S ribosomal protein L30 SH3K1_MOUSE SH3 domain-containing kinase-binding protein 1 HEM2_MOUSE Delta-aminolevulinic acid dehydratase ARF3_MOUSE ADP-ribosylation factor 3 SYHM_MOUSE Probable histidine--tRNA ligase, mitochondrial OS9_MOUSE Protein OS-9 TFR1_MOUSE Transferrin receptor protein 1 MGST1_MOUSE Microsomal glutathione S-transferase 1 CNN3_MOUSE Calponin-3 LRC59_MOUSE Leucine-rich repeat-containing protein 59 ATP5J_MOUSE ATP synthase-coupling factor 6, mitochondrial RS11_MOUSE 40S ribosomal protein S11 EMC3_MOUSE ER membrane protein complex subunit 3 AMPB_MOUSE Aminopeptidase B RL10_MOUSE 60S ribosomal protein L10 TM9S3_MOUSE Transmembrane 9 superfamily member 3 RRAS_MOUSE Ras-related protein R-Ras Q6A099_MOUSE MKIAA0248 protein (Fragment) PSB1_MOUSE Proteasome subunit beta type-1 NCOAT_MOUSE Bifunctional protein NCOAT SGPL1_MOUSE Sphingosine-1-phosphate lyase 1 RM15_MOUSE 39S ribosomal protein L15, mitochondrial ECHD1_MOUSE Ethylmalonyl-CoA decarboxylase TIM8A_MOUSE Mitochondrial import inner membrane translocase subunit Tim8 A PSMD6_MOUSE 26S proteasome non-ATPase regulatory subunit 6 RL9_MOUSE 60S ribosomal protein L9 ULA1_MOUSE NEDD8-activating enzyme E1 regulatory subunit S10AB_MOUSE Protein S100-A11
EP
Ssr1 Mrpl1 Capn2 Dpysl2 Tmed9 Ube2n Gps1 Prosc Pcyt2 Twf1 Rpl29 Dbnl Ctps2 Banf1 Prrc2a Hgs Psme3 Usp7 Pabpn1 Fam114a2 Ctsl Ap3d1 Ddah1 Dnajc8 Coq9 Rps14 Impa1 Plin3 Snx6 Mapre1 Ewsr1 Hist1h1e Cops5 Plcb3 Rpl30 Sh3kbp1 Alad Arf3 Hars2 Os9 Tfrc Mgst1 Cnn3 Lrrc59 Atp5j Rps11 Emc3 Rnpep Rpl10 Tm9sf3 Rras Gbf1 Psmb1 Mgea5 Sgpl1 Mrpl15 Echdc1 Timm8a1 Psmd6 Rpl9 Nae1 S100a11
AC C
sp|Q9CY50|SSRA_MOUSE sp|Q99N96|RM01_MOUSE sp|O08529|CAN2_MOUSE sp|O08553|DPYL2_MOUSE sp|Q99KF1|TMED9_MOUSE sp|P61089|UBE2N_MOUSE sp|Q99LD4|CSN1_MOUSE sp|Q9Z2Y8|PROSC_MOUSE sp|Q922E4|PCY2_MOUSE sp|Q91YR1|TWF1_MOUSE sp|P47915|RL29_MOUSE sp|Q62418|DBNL_MOUSE sp|P70303|PYRG2_MOUSE sp|O54962|BAF_MOUSE sp|Q7TSC1|PRC2A_MOUSE sp|Q99LI8|HGS_MOUSE sp|P61290|PSME3_MOUSE sp|Q6A4J8|UBP7_MOUSE sp|Q8CCS6|PABP2_MOUSE sp|Q8VE88-2|F1142_MOUSE sp|P06797|CATL1_MOUSE sp|O54774|AP3D1_MOUSE sp|Q9CWS0|DDAH1_MOUSE sp|Q6NZB0|DNJC8_MOUSE sp|Q8K1Z0|COQ9_MOUSE sp|P62264|RS14_MOUSE sp|O55023|IMPA1_MOUSE sp|Q9DBG5|PLIN3_MOUSE sp|Q6P8X1|SNX6_MOUSE sp|Q61166|MARE1_MOUSE sp|Q61545|EWS_MOUSE sp|P43274|H14_MOUSE sp|O35864|CSN5_MOUSE sp|P51432|PLCB3_MOUSE sp|P62889|RL30_MOUSE sp|Q8R550|SH3K1_MOUSE sp|P10518|HEM2_MOUSE sp|P61205|ARF3_MOUSE sp|Q99KK9|SYHM_MOUSE sp|Q8K2C7|OS9_MOUSE sp|Q62351|TFR1_MOUSE sp|Q91VS7|MGST1_MOUSE sp|Q9DAW9|CNN3_MOUSE sp|Q922Q8|LRC59_MOUSE sp|P97450|ATP5J_MOUSE sp|P62281|RS11_MOUSE sp|Q99KI3|EMC3_MOUSE sp|Q8VCT3|AMPB_MOUSE sp|Q6ZWV3|RL10_MOUSE sp|Q9ET30|TM9S3_MOUSE sp|P10833|RRAS_MOUSE tr|Q6A099|Q6A099_MOUSE sp|O09061|PSB1_MOUSE sp|Q9EQQ9|NCOAT_MOUSE sp|Q8R0X7|SGPL1_MOUSE sp|Q9CPR5|RM15_MOUSE sp|Q9D9V3|ECHD1_MOUSE sp|Q9WVA2|TIM8A_MOUSE sp|Q99JI4|PSMD6_MOUSE sp|P51410|RL9_MOUSE sp|Q8VBW6|ULA1_MOUSE sp|P50543|S10AB_MOUSE
629.158 710.168 650.963 546.104 631.017 959.581 790.105 641.529 776.545 537.15 1344.2 971.052 738.772 648.494 761.06 440.088 713.18 848.479 511.653 445.592 720.978 739.196 581.552 850.397 570.272 480.987 496.769 631.886 884.165 828.773 825.918 791.825 705.759 733.164 757.577 707.191 547.78 871.272 670.762 677.007 752.067 427.664 620.599 607.987 2118.4 847.13 576.85 754.37 502.356 845.715 794.895 626.885 582.162 578.933 580.551 984.281 742.924 838.472 634.936 564.47 469.816 605.175
737.373 561.898 915.112 513.312 621.046 1149.64 826.558 423.171 504.913 460.509 645.01 929.388 1324.77 662.343 526.751 490.012 861.361 718.65 384.786 731.799 438.168 547.957 719.416 832.018 340.417 1192.42 709.855 637.223 1076.35 578.452 977.981 1525.33 737.438 804.421 1163.25 752.446 414.559 766.958 468.951 484.163 103.548 1036.44 840.423 1227.26 531.727 656.771 633.899 582.832 1873.91 869.008 921.338 583.103 719.409 871.574 714.307 472.321 340.817 522.468 700.11 931.18 724.095 401.794
672.96 833.221 763.981 511.965 411.623 1936.44 700.133 701.908 596.556 450.425 1845.05 1417.45 1498.31 895.38 1085.63 551.622 1224.76 670.876 818.52 678.267 1087.47 638.222 1584.23 1548.45 676.98 1799.21 839.133 1229.53 1160.78 925.669 2146.99 1457.22 649.021 887.143 927.648 1601.89 429.318 767.54 629.266 1213.54 242.194 1131.83 1551.1 1427.43 2467.47 543.798 491.798 634.083 1523.52 538.615 448.651 516.255 523.171 803.299 482.825 724.196 462.9 1367.2 557.055 698.669 544.536 896.942
1.11 1.10 1.10 1.09 1.08 1.07 1.07 1.06 1.05 1.04 1.03 1.02 1.02 1.02 1.01 1.00 1.00 0.99 0.97 0.96 0.96 0.96 0.95 0.94 0.94 0.93 0.92 0.92 0.92 0.90 0.89 0.88 0.88 0.88 0.88 0.86 0.85 0.84 0.83 0.81 1.82 1.58 1.57 1.41 1.33 1.31 1.31 1.25 1.25 1.24 1.21 1.21 1.21 1.21 1.20 1.19 1.19 1.18 1.16 1.15 1.14 1.11
1.20 1.01 1.43 0.98 0.81 1.82 1.04 0.81 0.74 0.82 1.17 1.18 1.96 1.14 1.00 1.14 1.18 0.81 1.15 1.26 0.95 0.89 1.86 1.22 0.73 2.90 1.20 1.28 1.01 0.77 1.47 1.76 0.86 0.88 1.38 1.37 0.62 0.95 0.63 0.92 0.44 3.56 2.75 2.22 1.13 0.95 1.07 1.01 3.81 0.92 1.02 0.95 1.09 1.54 1.29 0.71 0.56 1.15 1.04 1.56 1.33 1.01
ACCEPTED MANUSCRIPT
TE D
398.108 672.92 441.657 715.023 680.154 516.508 668.878 808.048 675.596 621.643 528.451 613.353 620.873 477.568 630.801 481.056 545.472 478.352 544.244 810.655 673.063 454.966 723.764 438.155 634.973 674.302 550.664 708.447 881.577 1140.71 829.641 554.637 767.52 506.569 495.851 724.455 709.803 435.274 570.235 640.377 978.299 1128.3 817.25 696.717 820.81 1146.32 669.404 524.706 689.148 755.102 846.486 531.34 947.023 564.576 1001.58 723.357 531.082 468.777 371.096 705.81 789.941 612.395
459.7 870.179 481.073 661.171 833.052 533.138 727.073 745.764 890.045 587.014 664.759 692.23 688.864 510.203 795.541 515.738 582.462 532.909 707.638 895.454 739.012 584.051 798.625 512.527 704.973 891.195 690.792 731.795 1176.45 1091.86 820.097 625.322 784.377 502.312 553.288 767.887 644.109 457.248 544.907 656.48 966.949 1005.37 636.424 507.801 673.271 954.549 625.598 554.845 612.515 740.34 691.656 477.538 907.016 530.219 811.037 1035.96 1004.57 756.969 677.888 1070.98 1161.06 936.691
RI PT
377.624 784.043 432.834 618.568 769.057 482.511 688.537 619.852 844.467 555.366 638.077 635.507 596.315 483.614 746.445 454.128 602.788 560.919 734.28 825.388 722.028 541.393 735.162 474.575 657.528 927.41 676.542 713.047 1065.07 1236.15 706.968 584.391 752.14 475.426 566.509 804.987 571.494 484.938 498.82 598.475 882.93 918.173 564.981 708.104 676.269 894.113 642.052 547.171 569.461 910.342 770.015 453.062 1285.94 577.31 1015.78 654.979 623.948 350.105 415.77 638.322 749.154 745.474
SC
13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 12 12 12 12 12 12 12
M AN U
PGRC1_MOUSE Membrane-associated progesterone receptor component 1 CCAR2_MOUSE Cell cycle and apoptosis regulator protein 2 TBCD4_MOUSE TBC1 domain family member 4 HMGN5_MOUSE High mobility group nucleosome-binding domain-containing protein 5 S23IP_MOUSE SEC23-interacting protein ACPM_MOUSE Acyl carrier protein, mitochondrial CMC1_MOUSE Calcium-binding mitochondrial carrier protein Aralar1 DLRB1_MOUSE Dynein light chain roadblock-type 1 RMD1_MOUSE Regulator of microtubule dynamics protein 1 METK2_MOUSE S-adenosylmethionine synthase isoform type-2 LIS1_MOUSE Platelet-activating factor acetylhydrolase IB subunit alpha ARL3_MOUSE ADP-ribosylation factor-like protein 3 FUBP1_MOUSE Far upstream element-binding protein 1 SRRT_MOUSE Serrate RNA effector molecule homolog DYN2_MOUSE Dynamin-2 IF1AX_MOUSE Eukaryotic translation initiation factor 1A, X-chromosomal RAB5C_MOUSE Ras-related protein Rab-5C VA0D1_MOUSE V-type proton ATPase subunit d 1 HNRL1_MOUSE Heterogeneous nuclear ribonucleoprotein U-like protein 1 PTGR2_MOUSE Prostaglandin reductase 2 DHX15_MOUSE Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 SCPDL_MOUSE Saccharopine dehydrogenase-like oxidoreductase PCY1A_MOUSE Choline-phosphate cytidylyltransferase A NPL4_MOUSE Nuclear protein localization protein 4 homolog SNW1_MOUSE SNW domain-containing protein 1 PCCB_MOUSE Propionyl-CoA carboxylase beta chain, mitochondrial HS74L_MOUSE Heat shock 70 kDa protein 4L CYBP_MOUSE Calcyclin-binding protein CISD1_MOUSE CDGSH iron-sulfur domain-containing protein 1 RL21_MOUSE 60S ribosomal protein L21 NDUV2_MOUSE NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial IGBP1_MOUSE Immunoglobulin-binding protein 1 RU17_MOUSE U1 small nuclear ribonucleoprotein 70 kDa FKB1A_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP1A FNTA_MOUSE Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha XPP1_MOUSE Xaa-Pro aminopeptidase 1 AIP_MOUSE AH receptor-interacting protein RCC2_MOUSE Protein RCC2 HEBP1_MOUSE Heme-binding protein 1 CRKL_MOUSE Crk-like protein CFDP1_MOUSE Craniofacial development protein 1 UBE2H_MOUSE Ubiquitin-conjugating enzyme E2 H NUFP2_MOUSE Nuclear fragile X mental retardation-interacting protein 2 RS15A_MOUSE 40S ribosomal protein S15a Q3U741_MOUSE DEAD (Asp-Glu-Ala-Asp) box polypeptide 17, isoform CRA_a SKP1_MOUSE S-phase kinase-associated protein 1 B1AZ46_MOUSE Brain-specific angiogenesis inhibitor 1-associated protein 2 D3YWX2_MOUSE YLP motif-containing protein 1 SDHF2_MOUSE Succinate dehydrogenase assembly factor 2, mitochondrial PTPA_MOUSE Serine/threonine-protein phosphatase 2A activator HINT1_MOUSE Histidine triad nucleotide-binding protein 1 IF4H_MOUSE Eukaryotic translation initiation factor 4H ANM1_MOUSE Protein arginine N-methyltransferase 1 PCKGM_MOUSE Phosphoenolpyruvate carboxykinase [GTP], mitochondrial DHRS4_MOUSE Dehydrogenase/reductase SDR family member 4 F8VPN4_MOUSE Protein Agl ACSA_MOUSE Acetyl-coenzyme A synthetase, cytoplasmic AUHM_MOUSE Methylglutaconyl-CoA hydratase, mitochondrial LYRIC_MOUSE Protein LYRIC THTR_MOUSE Thiosulfate sulfurtransferase AGK_MOUSE Acylglycerol kinase, mitochondrial RT05_MOUSE 28S ribosomal protein S5, mitochondrial
EP
Pgrmc1 Ccar2 Tbc1d4 Hmgn5 Sec23ip Ndufab1 Slc25a12 Dynlrb1 Rmdn1 Mat2a Pafah1b1 Arl3 Fubp1 Srrt Dnm2 Eif1ax Rab5c Atp6v0d1 Hnrnpul1 Ptgr2 Dhx15 Sccpdh Pcyt1a Nploc4 Snw1 Pccb Hspa4l Cacybp Cisd1 Rpl21 Ndufv2 Igbp1 Snrnp70 Fkbp1a Fnta Xpnpep1 Aip Rcc2 Hebp1 Crkl Cfdp1 Ube2h Nufip2 Rps15a Ddx17 Skp1 Baiap2 Ylpm1 Sdhaf2 Ppp2r4 Hint1 Eif4h Prmt1 Pck2 Dhrs4 Agl Acss2 Auh Mtdh Tst Agk Mrps5
AC C
sp|O55022|PGRC1_MOUSE sp|Q8VDP4|CCAR2_MOUSE sp|Q8BYJ6|TBCD4_MOUSE sp|Q9JL35|HMGN5_MOUSE sp|Q6NZC7|S23IP_MOUSE sp|Q9CR21|ACPM_MOUSE sp|Q8BH59|CMC1_MOUSE sp|P62627|DLRB1_MOUSE sp|Q9DCV4|RMD1_MOUSE sp|Q3THS6|METK2_MOUSE sp|P63005|LIS1_MOUSE sp|Q9WUL7|ARL3_MOUSE sp|Q91WJ8|FUBP1_MOUSE sp|Q99MR6|SRRT_MOUSE sp|P39054|DYN2_MOUSE sp|Q8BMJ3|IF1AX_MOUSE sp|P35278|RAB5C_MOUSE sp|P51863|VA0D1_MOUSE sp|Q8VDM6|HNRL1_MOUSE sp|Q8VDQ1|PTGR2_MOUSE sp|O35286|DHX15_MOUSE sp|Q8R127|SCPDL_MOUSE sp|P49586|PCY1A_MOUSE sp|P60670|NPL4_MOUSE sp|Q9CSN1|SNW1_MOUSE sp|Q99MN9|PCCB_MOUSE sp|P48722|HS74L_MOUSE sp|Q9CXW3|CYBP_MOUSE sp|Q91WS0|CISD1_MOUSE sp|O09167|RL21_MOUSE sp|Q9D6J6|NDUV2_MOUSE sp|Q61249|IGBP1_MOUSE sp|Q62376|RU17_MOUSE sp|P26883|FKB1A_MOUSE sp|Q61239|FNTA_MOUSE sp|Q6P1B1|XPP1_MOUSE sp|O08915|AIP_MOUSE sp|Q8BK67|RCC2_MOUSE sp|Q9R257|HEBP1_MOUSE sp|P47941|CRKL_MOUSE sp|O88271|CFDP1_MOUSE sp|P62257|UBE2H_MOUSE sp|Q5F2E7|NUFP2_MOUSE sp|P62245|RS15A_MOUSE tr|Q3U741|Q3U741_MOUSE sp|Q9WTX5|SKP1_MOUSE tr|B1AZ46|B1AZ46_MOUSE tr|D3YWX2|D3YWX2_MOUSE sp|Q8C6I2|SDHF2_MOUSE sp|P58389|PTPA_MOUSE sp|P70349|HINT1_MOUSE sp|Q9WUK2|IF4H_MOUSE sp|Q9JIF0|ANM1_MOUSE sp|Q8BH04|PCKGM_MOUSE sp|Q99LB2|DHRS4_MOUSE tr|F8VPN4|F8VPN4_MOUSE sp|Q9QXG4|ACSA_MOUSE sp|Q9JLZ3|AUHM_MOUSE sp|Q80WJ7|LYRIC_MOUSE sp|P52196|THTR_MOUSE sp|Q9ESW4|AGK_MOUSE sp|Q99N87|RT05_MOUSE
396.396 736.668 472.344 784.437 714.326 525.752 708.754 761.906 704.144 644.826 542.616 595.05 565.485 476.774 616.39 433.86 580.185 518.963 585.536 756.975 669.739 421.547 666.653 400.255 585.757 701.811 529.025 675.673 742.662 1248.34 691.514 491.671 702.125 454.346 471.17 700.015 583.772 421.962 464.004 510.963 785.353 914.069 647.048 783.695 700.528 906.775 559.705 393.014 474.984 681.689 682.622 352.2 952.402 394.01 700.634 1350.94 877.306 519.709 500.329 787.982 907.599 812.622
730.67 1027.76 662.855 587.997 807.092 727.259 979.984 619.622 587.394 480.808 712.808 756.175 733.398 462.906 1329.66 479.613 627.192 917.453 473.602 611.266 922.613 872.677 482.129 556.435 405.698 506.525 783.913 702.832 980.313 849.978 533.269 360.802 656.794 479.316 589.06 674.766 536.283 722.555 654.482 437.41 549.61 864.148 497.632 776.763 1034.49 828.795 596.102 255.462 576.209 628.095 554.35 509.16 767.757 821.395 622.134 266.538 362.379 569.324 334.555 376.533 978.474 355.25
852.174 1111.11 596.257 1333.99 876.174 2309.02 610.204 1389.59 1032.16 722.582 639.274 1271.6 1349.24 711.427 954.905 827.609 539.139 927.741 440.166 1162.31 1044.22 652.601 990.728 675.846 876.798 848.836 586.637 899.809 805.112 1179 1153.48 701.034 1463.08 817.706 485.684 515.903 1100.31 500.044 1049.79 842.941 1155.93 1638.77 906.715 706.47 1360.91 1949.5 809.103 515.886 1338.26 543.657 1087.58 1236.14 757.274 2157.55 779.112 266.952 345.991 716.122 715.7 712.783 966.869 708.325
1.10 1.10 1.09 1.08 1.07 1.06 1.06 1.06 1.05 1.05 1.04 1.03 1.03 1.03 1.03 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.97 0.96 0.96 0.96 0.96 0.94 0.94 0.94 0.94 0.93 0.92 0.92 0.91 0.90 0.88 0.86 0.85 0.85 0.84 0.83 0.81 0.75 1.73 1.63 1.56 1.50 1.38 1.34 1.29
2.04 1.47 1.44 1.44 1.16 3.04 1.17 1.41 1.07 1.02 1.16 1.62 1.71 1.22 1.66 1.40 1.02 1.78 0.71 1.08 1.41 1.53 1.01 1.35 0.99 0.85 1.12 1.13 0.92 0.85 1.10 0.93 1.39 1.32 1.01 0.78 1.28 1.33 1.59 1.03 0.92 1.22 1.02 1.06 1.60 1.36 1.07 0.72 1.52 0.70 1.02 1.77 0.68 2.61 0.69 0.39 0.61 1.57 1.33 0.81 1.26 0.78
ACCEPTED MANUSCRIPT
TE D
487.575 464.11 1055.12 843.798 548.692 626.501 519.945 556.476 425.87 518.788 440.418 877.637 671.892 507.251 475.906 538.842 592.797 465.239 503.967 313.586 730.429 542.836 511.08 811.354 221.374 670.824 424.945 412.725 783.412 818 339.348 615.725 538.991 903.274 600.113 517.425 526.961 588.811 505.993 926.034 648.548 354.268 652.732 574.326 509.295 622.362 380.593 624.963 503.95 464.365 624.863 787.173 471.072 590.811 486.657 718.218 744.674 587.423 604.119 466.999 534.642 825.147
772.896 768.422 1569.55 1014.81 866.316 836.07 789.363 730.132 467.694 928.096 656.8 1269.07 951.242 639.416 602.753 640.353 625.381 616.266 683.604 417.263 959.164 601.396 569.787 821.216 1148.64 785.251 517.95 557.638 862.361 698.018 408.635 775.563 637.11 893.454 715.094 499.224 705.501 710.29 596.354 942.533 782.727 377.363 758.71 762.205 568.08 518.096 401.681 584.768 448.208 404.095 618.066 883.064 465.541 563.4 528.244 705.768 887.592 550.735 583.341 448.173 605.818 743.549
RI PT
559.395 578.73 1161.26 663.122 678.42 647.688 611.025 565.307 383.35 718.94 564.127 1060.32 899.22 539.624 507.963 536.923 519.976 498.959 572.814 356.395 896.158 522.327 475.839 688.827 1026.22 730.201 446.852 498.433 777.56 682.038 331.252 731.233 535.863 792.256 606.43 437.386 669.681 618.445 565.838 939.854 724.842 376.437 766.034 753.91 562.794 453.356 362.737 499.706 386.312 391.791 555.386 909.517 451.351 597.96 644.681 646.772 973.166 569.555 553.17 438.635 680.839 731.375
SC
12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12
M AN U
F8VQC7_MOUSE Kinectin ACTN1_MOUSE Alpha-actinin-1 RB11B_MOUSE Ras-related protein Rab-11B THIOM_MOUSE Thioredoxin, mitochondrial CSKP_MOUSE Peripheral plasma membrane protein CASK CYB5B_MOUSE Cytochrome b5 type B STIM1_MOUSE Stromal interaction molecule 1 HUWE1_MOUSE E3 ubiquitin-protein ligase HUWE1 NSUN2_MOUSE tRNA (cytosine(34)-C(5))-methyltransferase FAAA_MOUSE Fumarylacetoacetase ACAD9_MOUSE Acyl-CoA dehydrogenase family member 9, mitochondrial HA11_MOUSE H-2 class I histocompatibility antigen, D-B alpha chain RT27_MOUSE 28S ribosomal protein S27, mitochondrial RHG01_MOUSE Rho GTPase-activating protein 1 RHEB_MOUSE GTP-binding protein Rheb IF2G_MOUSE Eukaryotic translation initiation factor 2 subunit 3, X-linked VATH_MOUSE V-type proton ATPase subunit H SPRE_MOUSE Sepiapterin reductase ERLN2_MOUSE Erlin-2 DYL2_MOUSE Dynein light chain 2, cytoplasmic DCMC_MOUSE Malonyl-CoA decarboxylase, mitochondrial HCFC1_MOUSE Host cell factor 1 NUDC2_MOUSE NudC domain-containing protein 2 Q3TMX5_MOUSE Arginine-rich, mutated in early stage tumors, isoform CRA_b PDCD4_MOUSE Programmed cell death protein 4 RS25_MOUSE 40S ribosomal protein S25 MAP1A_MOUSE Microtubule-associated protein 1A B1AUN2_MOUSE MCG14442 MRP1_MOUSE Multidrug resistance-associated protein 1 HXK1_MOUSE Hexokinase-1 GRHPR_MOUSE Glyoxylate reductase/hydroxypyruvate reductase STAT3_MOUSE Signal transducer and activator of transcription 3 MTDC_MOUSE Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial IF1A_MOUSE Eukaryotic translation initiation factor 1A RSU1_MOUSE Ras suppressor protein 1 CDV3_MOUSE Protein CDV3 E9Q828_MOUSE Protein Atp2b4 CC90B_MOUSE Coiled-coil domain-containing protein 90B, mitochondrial LARP1_MOUSE La-related protein 1 MGN_MOUSE Protein mago nashi homolog QCR1_MOUSE Cytochrome b-c1 complex subunit 1, mitochondrial SC23A_MOUSE Protein transport protein Sec23A CSAD_MOUSE Cysteine sulfinic acid decarboxylase NDUV1_MOUSE NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial P3H1_MOUSE Prolyl 3-hydroxylase 1 EIF1_MOUSE Eukaryotic translation initiation factor 1 NASP_MOUSE Nuclear autoantigenic sperm protein OSTF1_MOUSE Osteoclast-stimulating factor 1 TEBP_MOUSE Prostaglandin E synthase 3 SUGT1_MOUSE Suppressor of G2 allele of SKP1 homolog SHLB1_MOUSE Endophilin-B1 NRDC_MOUSE Nardilysin Q99J77_MOUSE N-acetylneuraminic acid synthase (Sialic acid synthase) 1433F_MOUSE 14-3-3 protein eta RBM25_MOUSE RNA-binding protein 25 GORS2_MOUSE Golgi reassembly-stacking protein 2 ASNA_MOUSE ATPase Asna1 RBM8A_MOUSE RNA-binding protein 8A G3BP1_MOUSE Ras GTPase-activating protein-binding protein 1 GRSF1_MOUSE G-rich sequence factor 1 FAF1_MOUSE FAS-associated factor 1 TXLNA_MOUSE Alpha-taxilin
EP
Ktn1 Actn1 Rab11b Txn2 Cask Cyb5b Stim1 Huwe1 Nsun2 Fah Acad9 H2-D1 Mrps27 Arhgap1 Rheb Eif2s3x Atp6v1h Spr Erlin2 Dynll2 Mlycd Hcfc1 Nudcd2 Manf Pdcd4 Rps25 Map1a Eif2b3 Abcc1 Hk1 Grhpr Stat3 Mthfd2 Eif1a Rsu1 Cdv3 Atp2b4 Ccdc90b Larp1 Magoh Uqcrc1 Sec23a Csad Ndufv1 Lepre1 Eif1 Nasp Ostf1 Ptges3 Sugt1 Sh3glb1 Nrd1 Nans Ywhah Rbm25 Gorasp2 Asna1 Rbm8a G3bp1 Grsf1 Faf1 Txlna
AC C
tr|F8VQC7|F8VQC7_MOUSE sp|Q7TPR4|ACTN1_MOUSE sp|P46638|RB11B_MOUSE sp|P97493|THIOM_MOUSE sp|O70589|CSKP_MOUSE sp|Q9CQX2|CYB5B_MOUSE sp|P70302|STIM1_MOUSE sp|Q7TMY8|HUWE1_MOUSE sp|Q1HFZ0|NSUN2_MOUSE sp|P35505|FAAA_MOUSE sp|Q8JZN5|ACAD9_MOUSE sp|P01899|HA11_MOUSE sp|Q8BK72|RT27_MOUSE sp|Q5FWK3|RHG01_MOUSE sp|Q921J2|RHEB_MOUSE sp|Q9Z0N1|IF2G_MOUSE sp|Q8BVE3|VATH_MOUSE sp|Q64105|SPRE_MOUSE sp|Q8BFZ9|ERLN2_MOUSE sp|Q9D0M5|DYL2_MOUSE sp|Q99J39|DCMC_MOUSE sp|Q61191|HCFC1_MOUSE sp|Q9CQ48|NUDC2_MOUSE tr|Q3TMX5|Q3TMX5_MOUSE sp|Q61823|PDCD4_MOUSE sp|P62852|RS25_MOUSE sp|Q9QYR6|MAP1A_MOUSE tr|B1AUN2|B1AUN2_MOUSE sp|O35379|MRP1_MOUSE sp|P17710|HXK1_MOUSE sp|Q91Z53|GRHPR_MOUSE sp|P42227|STAT3_MOUSE sp|P18155|MTDC_MOUSE sp|Q60872|IF1A_MOUSE sp|Q01730|RSU1_MOUSE sp|Q4VAA2|CDV3_MOUSE tr|E9Q828|E9Q828_MOUSE sp|Q8C3X2|CC90B_MOUSE sp|Q6ZQ58|LARP1_MOUSE sp|P61327|MGN_MOUSE sp|Q9CZ13|QCR1_MOUSE sp|Q01405|SC23A_MOUSE sp|Q9DBE0|CSAD_MOUSE sp|Q91YT0|NDUV1_MOUSE sp|Q3V1T4|P3H1_MOUSE sp|P48024|EIF1_MOUSE sp|Q99MD9|NASP_MOUSE sp|Q62422|OSTF1_MOUSE sp|Q9R0Q7|TEBP_MOUSE sp|Q9CX34|SUGT1_MOUSE sp|Q9JK48|SHLB1_MOUSE sp|Q8BHG1|NRDC_MOUSE tr|Q99J77|Q99J77_MOUSE sp|P68510|1433F_MOUSE sp|B2RY56|RBM25_MOUSE sp|Q99JX3|GORS2_MOUSE sp|O54984|ASNA_MOUSE sp|Q9CWZ3|RBM8A_MOUSE sp|P97855|G3BP1_MOUSE sp|Q8C5Q4|GRSF1_MOUSE sp|P54731|FAF1_MOUSE sp|Q6PAM1|TXLNA_MOUSE
568.644 530.783 1177.23 828.365 629.59 716.392 586.887 634.367 511.631 558.461 548.984 1019.83 880.849 568.481 531.129 599.222 655.384 482.93 543.633 338.163 868.853 589.662 527.469 844.135 233.939 755.175 436.752 427.606 820.994 901.735 304.046 651.015 499.025 895.161 552.719 499.27 523.775 522.186 494.704 949.709 608.099 362.069 666.205 571.148 501.623 551.779 329.47 513.407 414.584 418.675 515.379 728.127 409.858 552.817 532.32 567.881 713.352 522.257 488.331 381.069 506.014 672.568
649.486 1217.19 1105.72 728.965 725.892 473.575 478.185 920.306 854.942 390.839 546.252 845.965 389.716 602.407 657.275 921.497 610.858 993.499 903.407 824.417 651.821 504.943 533.079 607.99 206.856 582.708 340.411 511.029 1005.99 2227.85 444.105 719.775 684.847 672.367 462.639 277.504 385.743 542.846 688.147 1033.55 562.505 402.003 610.24 706.667 402.524 420.01 978.897 888.387 1138.48 536.734 415.468 536.931 494.866 640.035 723.122 541.194 1273.66 337.19 495.928 314.752 529.832 504.128
1229.87 676.875 967.59 2290.55 651.896 849.369 1021.48 752.163 1123.03 343.714 521.285 1111.54 486.237 580.315 601.945 582.286 444.144 1214.2 1000.52 913.593 780.578 691.106 1031.47 1174.61 399.232 1459.72 358.605 527.638 844.013 628.294 501.98 529.314 1355.57 1165.02 572.825 430.163 349.857 679.153 697.603 1189.97 779.128 319.17 806.196 630.001 309.249 1468.16 767.236 1448.36 2630.8 795.192 804.094 613.039 670.71 603.834 940.817 1121.73 1074.07 702.151 1083.04 950.707 638.383 1223.32
1.28 1.25 1.24 1.22 1.22 1.22 1.22 1.22 1.21 1.20 1.20 1.18 1.17 1.15 1.15 1.15 1.15 1.14 1.14 1.13 1.12 1.12 1.11 1.11 1.11 1.10 1.10 1.08 1.08 1.07 1.06 1.06 1.06 1.05 1.05 1.05 1.03 1.02 1.02 1.01 1.01 1.01 1.00 1.00 1.00 0.99 0.98 0.98 0.97 0.96 0.96 0.95 0.95 0.94 0.94 0.93 0.93 0.93 0.93 0.92 0.91 0.91
1.80 1.82 0.94 2.00 1.12 1.04 1.33 1.49 2.44 0.59 1.06 1.01 0.56 1.13 1.28 1.40 0.95 2.29 1.77 2.59 0.88 1.12 1.59 1.19 0.49 1.46 0.80 1.14 1.19 1.90 1.41 0.93 1.90 1.08 0.86 0.74 0.61 1.01 1.29 1.19 0.98 0.99 1.00 1.01 0.66 1.76 2.35 2.08 4.23 1.56 1.03 0.68 1.26 1.05 1.47 1.22 1.37 0.90 1.36 1.40 0.96 1.11
ACCEPTED MANUSCRIPT
TE D
532.715 493.301 628.041 393.515 566.373 853.534 470.467 570.445 424.104 714.986 825.34 507.972 854.003 408.601 455.138 698.995 311.823 306.937 406.273 497.527 525.481 402.799 648.672 409.65 521.349 678.29 1196.99 485.893 678.014 342.081 751.205 664.13 584.779 332.443 374.569 584.26 265.962 436.123 555.595 546.823 559.089 506.039 654.249 854.822 544.058 439.541 364.226 557.082 639.203 546.693 479.788 428.413 564.814 472.932 437.979 638.396 1067.63 457.861 847.319 627.854 499.964 488.304
633.689 501.464 514.581 422.701 617.828 663.18 414.256 647.224 306.821 634.073 728.212 504.691 563.293 843.14 859.484 931.836 526.972 491.834 685.382 830.567 811.597 539.04 911.16 752.155 735.323 622.79 1184.51 778.597 954.688 544.414 658.743 1111.4 944.281 465.979 549.739 912.508 427.878 629.992 728.357 721.715 725.49 694.502 916.711 859.628 739.163 505.14 324.134 716.68 928.151 626.101 436.268 603.358 654.872 607.922 483.784 851.56 763.317 524.814 937.515 719.095 650.099 614.645
RI PT
712.234 511.552 633.278 487.721 692.529 683.948 560.257 743.448 398.424 667.676 777.143 637.675 642.1 435.149 404.284 403.37 318.674 316.948 461.968 684.394 557.261 345.641 597.426 458.417 516.163 429.439 1043.55 553.229 774.725 414.486 639.906 727.493 687.867 390.117 428.557 690.293 319.458 524.172 599.335 621.193 542.081 551.352 734.326 752.399 603.994 430.544 334.902 637.748 771.716 583.366 490.147 532.323 626.29 501.782 415.091 748.028 889.26 439.511 818.646 550.437 583.583 565.299
SC
12 12 12 12 12 12 12 12 12 12 12 12 12 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
M AN U
PNPT1_MOUSE Polyribonucleotide nucleotidyltransferase 1, mitochondrial GEPH_MOUSE Gephyrin EIF3M_MOUSE Eukaryotic translation initiation factor 3 subunit M ENTP5_MOUSE Ectonucleoside triphosphate diphosphohydrolase 5 SNX5_MOUSE Sorting nexin-5 RL35_MOUSE 60S ribosomal protein L35 CAZA2_MOUSE F-actin-capping protein subunit alpha-2 PLCB1_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 IPO7_MOUSE Importin-7 LZIC_MOUSE Protein LZIC GRN_MOUSE Granulins IMDH1_MOUSE Inosine-5'-monophosphate dehydrogenase 1 ANXA2_MOUSE Annexin A2 HYEP_MOUSE Epoxide hydrolase 1 COX6C_MOUSE Cytochrome c oxidase subunit 6C NDUA4_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 PLXB2_MOUSE Plexin-B2 GUAD_MOUSE Guanine deaminase MYOF_MOUSE Myoferlin ADIPO_MOUSE Adiponectin ACOX1_MOUSE Peroxisomal acyl-coenzyme A oxidase 1 NHRF1_MOUSE Na(+)/H(+) exchange regulatory cofactor NHE-RF1 RN213_MOUSE E3 ubiquitin-protein ligase RNF213 TMTC3_MOUSE Transmembrane and TPR repeat-containing protein 3 F120A_MOUSE Constitutive coactivator of PPAR-gamma-like protein 1 IF4B_MOUSE Eukaryotic translation initiation factor 4B RL28_MOUSE 60S ribosomal protein L28 SRPK1_MOUSE SRSF protein kinase 1 TMEDA_MOUSE Transmembrane emp24 domain-containing protein 10 MFN2_MOUSE Mitofusin-2 CATB_MOUSE Cathepsin B CAB45_MOUSE 45 kDa calcium-binding protein SQRD_MOUSE Sulfide:quinone oxidoreductase, mitochondrial VPP1_MOUSE V-type proton ATPase 116 kDa subunit a isoform 1 SMC1A_MOUSE Structural maintenance of chromosomes protein 1A ASAH1_MOUSE Acid ceramidase STX4_MOUSE Syntaxin-4 PAPS1_MOUSE Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 DRG1_MOUSE Developmentally-regulated GTP-binding protein 1 AT131_MOUSE Probable cation-transporting ATPase 13A1 ARFG1_MOUSE ADP-ribosylation factor GTPase-activating protein 1 NUP93_MOUSE Nuclear pore complex protein Nup93 PRAF3_MOUSE PRA1 family protein 3 RETST_MOUSE All-trans-retinol 13,14-reductase THTM_MOUSE 3-mercaptopyruvate sulfurtransferase GFPT1_MOUSE Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 IPO9_MOUSE Importin-9 SCMC1_MOUSE Calcium-binding mitochondrial carrier protein SCaMC-1 TB10B_MOUSE TBC1 domain family member 10B ATLA2_MOUSE Atlastin-2 RL35A_MOUSE 60S ribosomal protein L35a PLCG1_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 RAB10_MOUSE Ras-related protein Rab-10 RT22_MOUSE 28S ribosomal protein S22, mitochondrial FRIH_MOUSE Ferritin heavy chain DCPS_MOUSE m7GpppX diphosphatase ACOD1_MOUSE Acyl-CoA desaturase 1 SNP23_MOUSE Synaptosomal-associated protein 23 UFD1_MOUSE Ubiquitin fusion degradation protein 1 homolog ZC3HF_MOUSE Zinc finger CCCH domain-containing protein 15 ARM10_MOUSE Armadillo repeat-containing protein 10 UBP15_MOUSE Ubiquitin carboxyl-terminal hydrolase 15
EP
Pnpt1 Gphn Eif3m Entpd5 Snx5 Rpl35 Capza2 Plcb1 Ipo7 Lzic Grn Impdh1 Anxa2 Ephx1 Cox6c Ndufa4 Plxnb2 Gda Myof Adipoq Acox1 Slc9a3r1 Rnf213 Tmtc3 FAM120A Eif4b Rpl28 Srpk1 Tmed10 Mfn2 Ctsb Sdf4 Sqrdl Atp6v0a1 Smc1a Asah1 Stx4 Papss1 Drg1 Atp13a1 Arfgap1 Nup93 Arl6ip5 Retsat Mpst Gfpt1 Ipo9 Slc25a24 Tbc1d10b Atl2 Rpl35a Plcg1 Rab10 Mrps22 Fth1 Dcps Scd1 Snap23 Ufd1l Zc3h15 Armc10 Usp15
AC C
sp|Q8K1R3|PNPT1_MOUSE sp|Q8BUV3|GEPH_MOUSE sp|Q99JX4|EIF3M_MOUSE sp|Q9WUZ9|ENTP5_MOUSE sp|Q9D8U8|SNX5_MOUSE sp|Q6ZWV7|RL35_MOUSE sp|P47754|CAZA2_MOUSE sp|Q9Z1B3|PLCB1_MOUSE sp|Q9EPL8|IPO7_MOUSE sp|Q8K3C3|LZIC_MOUSE sp|P28798|GRN_MOUSE sp|P50096|IMDH1_MOUSE sp|P07356|ANXA2_MOUSE sp|Q9D379|HYEP_MOUSE sp|Q9CPQ1|COX6C_MOUSE sp|Q62425|NDUA4_MOUSE sp|B2RXS4|PLXB2_MOUSE sp|Q9R111|GUAD_MOUSE sp|Q69ZN7|MYOF_MOUSE sp|Q60994|ADIPO_MOUSE sp|Q9R0H0|ACOX1_MOUSE sp|P70441|NHRF1_MOUSE sp|E9Q555|RN213_MOUSE sp|Q8BRH0|TMTC3_MOUSE sp|Q6A0A9|F120A_MOUSE sp|Q8BGD9|IF4B_MOUSE sp|P41105|RL28_MOUSE sp|O70551|SRPK1_MOUSE sp|Q9D1D4|TMEDA_MOUSE sp|Q80U63|MFN2_MOUSE sp|P10605|CATB_MOUSE sp|Q61112|CAB45_MOUSE sp|Q9R112|SQRD_MOUSE sp|Q9Z1G4|VPP1_MOUSE sp|Q9CU62|SMC1A_MOUSE sp|Q9WV54|ASAH1_MOUSE sp|P70452|STX4_MOUSE sp|Q60967|PAPS1_MOUSE sp|P32233|DRG1_MOUSE sp|Q9EPE9|AT131_MOUSE sp|Q9EPJ9|ARFG1_MOUSE sp|Q8BJ71|NUP93_MOUSE sp|Q8R5J9|PRAF3_MOUSE sp|Q64FW2|RETST_MOUSE sp|Q99J99|THTM_MOUSE sp|P47856|GFPT1_MOUSE sp|Q91YE6|IPO9_MOUSE sp|Q8BMD8|SCMC1_MOUSE sp|Q8BHL3|TB10B_MOUSE sp|Q6PA06|ATLA2_MOUSE sp|O55142|RL35A_MOUSE sp|Q62077|PLCG1_MOUSE sp|P61027|RAB10_MOUSE sp|Q9CXW2|RT22_MOUSE sp|P09528|FRIH_MOUSE sp|Q9DAR7|DCPS_MOUSE sp|P13516|ACOD1_MOUSE sp|O09044|SNP23_MOUSE sp|P70362|UFD1_MOUSE sp|Q3TIV5|ZC3HF_MOUSE sp|Q9D0L7|ARM10_MOUSE sp|Q8R5H1|UBP15_MOUSE
494.686 403.025 620.477 361.643 475.27 667.646 477.423 488.021 403.304 558.052 635.585 390.627 567.105 826.826 796.267 810.163 420.944 427.642 590.25 896.845 765.495 544.05 884.309 495.089 734.445 904.7 1828.18 606.34 951.294 446.529 1136.04 683.434 661.374 427.682 436.022 650.82 286.572 522.037 648.734 665.178 576.332 543.476 707.232 981.491 563.604 479.861 466.567 634.064 653.848 638.961 648.379 467.67 663.723 467.744 454.786 657.869 1358.48 443.504 850.192 543.509 510.628 512.036
432.457 510.815 923.771 712.755 479.962 588.42 1022.28 604.305 1356.19 725.659 466.461 675.673 1265.75 807.302 1064.26 460.521 576.611 457.728 704.873 100.326 895.079 306.224 981.647 655.719 608.47 548.937 943.325 838.362 720.059 229.372 358.439 193.973 278.556 412.601 366.374 389.972 551.562 499.728 652.415 601.697 334.815 746.107 661.718 369.833 272.136 906.343 353.274 954.095 594.326 648.51 485.257 509.585 658.301 373.467 939.417 664.03 311.314 364.993 752.361 506.155 607.865 406.441
527.887 786.708 605.448 964.536 498.479 915.64 1216.9 654.776 815.762 1436.75 937.87 996.707 424.991 722.367 488.748 935.081 376.274 526.551 429.409 204.915 389.927 617.252 805.395 338.204 591.981 822.841 1147.12 951.594 546.065 240.603 852.9 542.841 540.865 355.824 442.068 387.182 432.733 444.912 489.115 613.183 795.114 451.612 467.363 851.159 884.154 614.111 339.221 613.772 522.628 737.245 423.531 476.182 518.031 584.659 1288.95 620.456 1109.09 571.766 1176.27 924.212 533.032 558.91
0.91 0.90 0.90 0.89 0.87 0.87 0.87 0.86 0.86 0.86 0.85 0.78 0.76 1.98 1.93 1.58 1.50 1.47 1.47 1.46 1.46 1.45 1.44 1.44 1.42 1.38 1.34 1.33 1.31 1.31 1.29 1.29 1.26 1.24 1.23 1.23 1.22 1.20 1.19 1.19 1.18 1.17 1.17 1.15 1.13 1.13 1.13 1.13 1.12 1.12 1.12 1.11 1.11 1.10 1.10 1.09 1.08 1.08 1.07 1.07 1.07 1.07
0.77 1.29 1.21 1.90 0.78 0.98 2.17 0.96 2.64 1.56 0.88 1.46 1.13 1.81 1.81 1.27 1.51 1.58 1.31 0.26 1.19 1.23 1.43 1.14 1.16 1.24 0.93 1.72 0.87 0.62 0.87 0.53 0.64 1.06 1.01 0.61 1.68 0.98 0.99 1.04 1.03 1.13 0.81 0.76 1.01 1.75 0.99 1.31 0.79 1.23 0.94 1.03 0.99 0.98 2.61 0.93 0.73 1.04 1.16 1.21 1.05 0.92
ACCEPTED MANUSCRIPT
M AN U
TE D
423.977 433.422 998.461 328.836 688.072 859.908 629.248 517.228 544.41 462.929 591.04 392.809 440.371 365.488 574.124 653.701 431.561 496.608 496.32 702.222 662.805 484.176 416.81 546.777 645.934 442.885 607.842 676.59 500.913 443.017 556.199 568.581 349.145 533.062 382.852 490.654 1020.09 457.544 417.366 576.447 610.667 1141.9 800.704 359.174 438.174 590.076 504.744 506.088 543.077 795.406 595.466 520.394 586.4 213.544 589.686 388.198 666.511 298.865 239.253 342.212 337.386 483.576
528.442 515.316 1196.81 343.509 546.894 962.707 625.335 601.846 678.693 523.007 677.799 356.778 502.081 413.616 668.185 640.386 507.217 600.656 606.501 768.043 750.559 511.038 437.058 558.695 720.508 439.489 760.245 625.316 575.601 503.919 635.151 677.826 364.978 686.144 390.987 447.944 1073.13 518.673 426.511 473.842 521.749 1011.71 872.906 351.637 482.898 541.173 520.793 443.276 397.382 703.75 674.325 531.815 502.402 183.53 468.769 682.09 1266.17 620.56 389.993 616.768 586.31 841.533
RI PT
461.285 453.468 960.621 288.411 542.306 846.564 534.527 521.577 633.436 449.844 646.733 320.177 476.614 472.661 630.902 601.752 498.665 600.556 472.663 761.768 694.502 529.784 416.123 602.587 610.397 403.181 713.868 560.965 601.157 515.864 613.034 641.729 323.077 710.013 361.914 505.574 1021.12 478.986 462.154 431.585 689.569 1090.74 1038.67 427.644 538.2 548.328 624.602 450.387 411.07 793.153 780.836 578.741 547.954 270.75 633.604 353.618 560.828 402.966 263.323 473.775 367.905 545.969
SC
NH2L1_MOUSE NHP2-like protein 1 11 NUP98_MOUSE Nuclear pore complex protein Nup98-Nup96 11 RM12_MOUSE 39S ribosomal protein L12, mitochondrial 11 SMCE1_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily11 E member 1 G3BP2_MOUSE Ras GTPase-activating protein-binding protein 2 11 ORN_MOUSE Oligoribonuclease, mitochondrial 11 HOOK3_MOUSE Protein Hook homolog 3 11 NDUA8_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 11 NB5R1_MOUSE NADH-cytochrome b5 reductase 1 11 NDUS4_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 11 ELP1_MOUSE Elongator complex protein 1 11 TBB6_MOUSE Tubulin beta-6 chain 11 AKAP1_MOUSE A-kinase anchor protein 1, mitochondrial 11 EMC2_MOUSE ER membrane protein complex subunit 2 11 DYR_MOUSE Dihydrofolate reductase 11 UAP1_MOUSE UDP-N-acetylhexosamine pyrophosphorylase 11 NDUS3_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial 11 AFG31_MOUSE AFG3-like protein 1 11 GRAP1_MOUSE GRIP1-associated protein 1 11 RL27_MOUSE 60S ribosomal protein L27 11 AAPK1_MOUSE 5'-AMP-activated protein kinase catalytic subunit alpha-1 11 MTNB_MOUSE Methylthioribulose-1-phosphate dehydratase 11 F6ZFU0_MOUSE Elongation factor 1-delta (Fragment) 11 BACH_MOUSE Cytosolic acyl coenzyme A thioester hydrolase 11 ATX2L_MOUSE Ataxin-2-like protein 11 GLRX1_MOUSE Glutaredoxin-1 11 HEM3_MOUSE Porphobilinogen deaminase 11 ELOB_MOUSE Transcription elongation factor B polypeptide 2 11 DX39B_MOUSE Spliceosome RNA helicase Ddx39b 11 ANR17_MOUSE Ankyrin repeat domain-containing protein 17 11 MIMIT_MOUSE Mimitin, mitochondrial 11 DYST_MOUSE Dystonin 11 NNRD_MOUSE ATP-dependent (S)-NAD(P)H-hydrate dehydratase 11 PDXK_MOUSE Pyridoxal kinase 11 PSMD4_MOUSE 26S proteasome non-ATPase regulatory subunit 4 11 PIPNA_MOUSE Phosphatidylinositol transfer protein alpha isoform 11 THOC4_MOUSE THO complex subunit 4 11 RBM26_MOUSE RNA-binding protein 26 11 ARP3_MOUSE Actin-related protein 3 11 HNRDL_MOUSE Heterogeneous nuclear ribonucleoprotein D-like 11 SYNC_MOUSE Asparagine--tRNA ligase, cytoplasmic 11 SGTA_MOUSE Small glutamine-rich tetratricopeptide repeat-containing protein alpha 11 MPPA_MOUSE Mitochondrial-processing peptidase subunit alpha 11 CTBP1_MOUSE C-terminal-binding protein 1 11 D3Z0K8_MOUSE Thioredoxin reductase 2, mitochondrial 11 CYTB_MOUSE Cystatin-B 11 PSIP1_MOUSE PC4 and SFRS1-interacting protein 11 LEG3_MOUSE Galectin-3 11 ATX2_MOUSE Ataxin-2 11 TFAM_MOUSE Transcription factor A, mitochondrial 11 KAT1_MOUSE Kynurenine--oxoglutarate transaminase 1 11 FA13A_MOUSE Protein FAM13A 11 PININ_MOUSE Pinin 11 SERB_MOUSE Phosphoserine phosphatase 11 TCP4_MOUSE Activated RNA polymerase II transcriptional coactivator p15 11 GSTK1_MOUSE Glutathione S-transferase kappa 1 10 NDUF4_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 10 CO5A2_MOUSE Collagen alpha-2(V) chain 10 S27A1_MOUSE Long-chain fatty acid transport protein 1 10 KAT3_MOUSE Kynurenine--oxoglutarate transaminase 3 10 AT1B3_MOUSE Sodium/potassium-transporting ATPase subunit beta-3 10 SRPRB_MOUSE Signal recognition particle receptor subunit beta 10
EP
Nhp2l1 Nup98 Mrpl12 Smarce1 G3bp2 Rexo2 Hook3 Ndufa8 Cyb5r1 Ndufs4 Ikbkap Tubb6 Akap1 Emc2 Dhfr Uap1 Ndufs3 Afg3l1 Gripap1 Rpl27 Prkaa1 Apip Eef1d Acot7 Atxn2l Glrx Hmbs Tceb2 Ddx39b Ankrd17 Ndufaf2 Dst Carkd Pdxk Psmd4 Pitpna Alyref Rbm26 Actr3 Hnrnpdl Nars Sgta Pmpca Ctbp1 Txnrd2 Cstb Psip1 Lgals3 Atxn2 Tfam Ccbl1 Fam13a Pnn Psph Sub1 Gstk1 Ndufaf4 Col5a2 Slc27a1 Ccbl2 Atp1b3 Srprb
AC C
sp|Q9D0T1|NH2L1_MOUSE sp|Q6PFD9|NUP98_MOUSE sp|Q9DB15|RM12_MOUSE sp|O54941|SMCE1_MOUSE sp|P97379|G3BP2_MOUSE sp|Q9D8S4|ORN_MOUSE sp|Q8BUK6|HOOK3_MOUSE sp|Q9DCJ5|NDUA8_MOUSE sp|Q9DB73|NB5R1_MOUSE sp|Q9CXZ1|NDUS4_MOUSE sp|Q7TT37|ELP1_MOUSE sp|Q922F4|TBB6_MOUSE sp|O08715|AKAP1_MOUSE sp|Q9CRD2|EMC2_MOUSE sp|P00375|DYR_MOUSE sp|Q91YN5|UAP1_MOUSE sp|Q9DCT2|NDUS3_MOUSE sp|Q920A7|AFG31_MOUSE sp|Q8VD04|GRAP1_MOUSE sp|P61358|RL27_MOUSE sp|Q5EG47|AAPK1_MOUSE sp|Q9WVQ5|MTNB_MOUSE tr|F6ZFU0|F6ZFU0_MOUSE sp|Q91V12|BACH_MOUSE sp|Q7TQH0|ATX2L_MOUSE sp|Q9QUH0|GLRX1_MOUSE sp|P22907|HEM3_MOUSE sp|P62869|ELOB_MOUSE sp|Q9Z1N5|DX39B_MOUSE sp|Q99NH0|ANR17_MOUSE sp|Q59J78|MIMIT_MOUSE sp|Q91ZU6|DYST_MOUSE sp|Q9CZ42|NNRD_MOUSE sp|Q8K183|PDXK_MOUSE sp|O35226|PSMD4_MOUSE sp|P53810|PIPNA_MOUSE sp|O08583|THOC4_MOUSE sp|Q6NZN0|RBM26_MOUSE sp|Q99JY9|ARP3_MOUSE sp|Q9Z130|HNRDL_MOUSE sp|Q8BP47|SYNC_MOUSE sp|Q8BJU0|SGTA_MOUSE sp|Q9DC61|MPPA_MOUSE sp|O88712|CTBP1_MOUSE tr|D3Z0K8|D3Z0K8_MOUSE sp|Q62426|CYTB_MOUSE sp|Q99JF8|PSIP1_MOUSE sp|P16110|LEG3_MOUSE sp|O70305|ATX2_MOUSE sp|P40630|TFAM_MOUSE sp|Q8BTY1|KAT1_MOUSE sp|Q8BGI4|FA13A_MOUSE sp|O35691|PININ_MOUSE sp|Q99LS3|SERB_MOUSE sp|P11031|TCP4_MOUSE sp|Q9DCM2|GSTK1_MOUSE sp|Q9D1H6|NDUF4_MOUSE sp|Q3U962|CO5A2_MOUSE sp|Q60714|S27A1_MOUSE sp|Q71RI9|KAT3_MOUSE sp|P97370|AT1B3_MOUSE sp|P47758|SRPRB_MOUSE
417.019 431.839 880.996 311.042 757.819 843.287 592.96 483.274 547.638 421.493 602.233 380.005 442.685 446.775 568.147 647.27 439.895 516.412 378.604 715.196 621.21 513.105 390.696 581.148 524.277 391.059 530.188 579.523 497.325 428.658 494.544 488.83 282.847 511.139 312.101 488.396 845.125 361.367 391.736 459.029 662.88 1011.62 773.193 344.881 375.373 456.185 465.647 387.871 422.58 640.935 476.608 378.62 425.79 162.213 336.489 552.023 754.71 408.48 334.512 548.692 418.599 613.477
1053.01 455.837 564.432 417.484 482.9 603.336 511.885 535.368 646.343 463.412 710.419 1044.69 489.588 390.155 649.755 666.278 423.239 326.496 363.761 609.457 822.294 398.95 426.255 668.641 600.842 1106.77 1377.1 496.132 1229.25 643.569 395.938 572.731 703.178 582.94 455.045 412.721 638.27 379.117 708.278 429.199 936.576 872.541 637.495 588.668 372.94 678.067 681.258 480.479 690.828 659.819 1163.41 202.243 320.566 810.841 549.617 518.638 642.491 192.04 155.075 395.534 590.618 1084.03
885.855 790.168 1688.52 616.067 1156.08 1495.28 718.008 718.68 482.379 689.712 456.617 1456.88 812.962 404.612 799.587 589.772 341.373 627.503 791.39 825.197 607.59 929.595 1191.38 607.717 767.031 3152.44 1237.05 1013.22 806.934 745.648 585.991 642.62 1024.7 633.74 817.457 655.099 1114.36 509.041 620.974 1072.07 649.771 1933.78 1319.28 631.142 432.133 1262.87 865.024 888.361 1481.81 1296.46 953.027 933.491 709.086 1100.8 806.005 497.05 825.566 241.074 178.528 476.257 519.721 1439.29
1.07 1.07 1.06 1.06 1.06 1.06 1.05 1.04 1.04 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.02 1.02 1.02 1.01 1.01 1.01 0.99 0.99 0.99 0.98 0.98 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.94 0.94 0.94 0.94 0.93 0.93 0.91 0.91 0.89 0.89 0.88 0.88 0.87 0.87 0.86 0.85 0.84 0.83 0.82 0.71 0.66 1.66 1.65 1.47 1.44 1.43 1.42 1.41
2.19 1.40 1.15 1.67 1.33 1.23 1.06 1.21 0.96 1.26 0.94 3.51 1.42 0.95 1.20 1.00 0.82 0.87 1.19 0.98 1.05 1.31 1.94 1.11 1.09 5.03 1.98 1.22 1.85 1.45 0.84 1.00 2.57 0.98 1.71 1.07 0.86 0.95 1.51 1.49 1.22 1.26 1.06 1.55 0.82 1.70 1.37 1.43 2.28 1.23 1.54 1.03 0.91 3.95 1.11 1.37 1.20 0.62 0.66 1.07 1.57 2.45
ACCEPTED MANUSCRIPT
TE D
595.39 872.977 357.545 241.082 563.542 403.163 396.761 381.69 495.331 427.673 511.789 419.23 345.014 307.029 455.363 406.444 476.591 525.653 482.569 680.116 541.984 459.568 486 439.893 495.878 582.448 316.406 667.161 543.116 463.052 456.055 568.015 717.075 518.017 734.059 468.489 427.175 343.39 432.523 583.905 660.955 291.212 416.696 555.253 429.415 330.427 248.03 603.874 402.482 474.646 439.627 448.489 803.801 614.867 473.3 479.79 412.759 448.326 315.655 348.969 340.703 468.331
724.189 851.086 580.42 412.112 851.523 658.43 442.788 581.35 814.705 568.222 806.886 579.305 588.272 464.044 699.13 487.804 779.939 498.919 664.168 984.757 666.975 637.526 512.775 606.431 648.039 787.238 457.401 878.695 497.316 478.247 590.029 634.706 985.543 716.361 761.037 576.871 575.266 430.279 557.274 728.72 770.934 364.716 581.742 632.649 474.951 435.85 300.248 738.18 525.762 561.397 484.163 522.726 859.724 666.328 456.254 587.351 463.708 582.528 401.304 396.619 403.145 535.598
RI PT
455.841 720.513 380.902 264.544 563.504 445.042 252.449 425.003 524.267 407.169 594.908 420.216 443.708 335.284 588.989 363.044 667.026 422.933 559.269 780.625 524.319 504.448 430.356 511.435 483.549 692.773 365.682 708.348 446.368 469.923 489.208 475.905 800.041 629.526 642.57 526.07 511.617 385.593 500.351 541.7 643.235 294.452 515.299 497.624 446.015 442.585 275.539 682.558 422.05 497.396 403.134 480.99 874.903 591.567 396.934 520.735 410.406 491.561 375.639 414.797 368.741 519.232
SC
10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
M AN U
HPT_MOUSE Haptoglobin SFPQ_MOUSE Splicing factor, proline- and glutamine-rich AT1A2_MOUSE Sodium/potassium-transporting ATPase subunit alpha-2 CSRP1_MOUSE Cysteine and glycine-rich protein 1 TECR_MOUSE Very-long-chain enoyl-CoA reductase PGBM_MOUSE Basement membrane-specific heparan sulfate proteoglycan core protein RL12_MOUSE 60S ribosomal protein L12 K6PF_MOUSE 6-phosphofructokinase, muscle type S10AA_MOUSE Protein S100-A10 AMACR_MOUSE Alpha-methylacyl-CoA racemase T120A_MOUSE Transmembrane protein 120A RBGPR_MOUSE Rab3 GTPase-activating protein non-catalytic subunit MCCB_MOUSE Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial ARFG2_MOUSE ADP-ribosylation factor GTPase-activating protein 2 DHTK1_MOUSE Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial MECR_MOUSE Trans-2-enoyl-CoA reductase, mitochondrial BAZ1B_MOUSE Tyrosine-protein kinase BAZ1B S10A6_MOUSE Protein S100-A6 LIPB1_MOUSE Liprin-beta-1 PSMD8_MOUSE 26S proteasome non-ATPase regulatory subunit 8 NSF_MOUSE Vesicle-fusing ATPase NUP88_MOUSE Nuclear pore complex protein Nup88 LIMA1_MOUSE LIM domain and actin-binding protein 1 G3X922_MOUSE MCG115602 RM41_MOUSE 39S ribosomal protein L41, mitochondrial LACTB_MOUSE Serine beta-lactamase-like protein LACTB, mitochondrial ARFG3_MOUSE ADP-ribosylation factor GTPase-activating protein 3 RB3GP_MOUSE Rab3 GTPase-activating protein catalytic subunit PCNA_MOUSE Proliferating cell nuclear antigen GMDS_MOUSE GDP-mannose 4,6 dehydratase GAR1_MOUSE H/ACA ribonucleoprotein complex subunit 1 NUP50_MOUSE Nuclear pore complex protein Nup50 COASY_MOUSE Bifunctional coenzyme A synthase MIRO1_MOUSE Mitochondrial Rho GTPase 1 TIM10_MOUSE Mitochondrial import inner membrane translocase subunit Tim10 MTA2_MOUSE Metastasis-associated protein MTA2 UBA6_MOUSE Ubiquitin-like modifier-activating enzyme 6 HMOX2_MOUSE Heme oxygenase 2 AL3A2_MOUSE Fatty aldehyde dehydrogenase ISCU_MOUSE Iron-sulfur cluster assembly enzyme ISCU, mitochondrial DJB11_MOUSE DnaJ homolog subfamily B member 11 PPAC_MOUSE Low molecular weight phosphotyrosine protein phosphatase SAHH2_MOUSE Putative adenosylhomocysteinase 2 TIM9_MOUSE Mitochondrial import inner membrane translocase subunit Tim9 PSD13_MOUSE 26S proteasome non-ATPase regulatory subunit 13 SAM50_MOUSE Sorting and assembly machinery component 50 homolog IMA3_MOUSE Importin subunit alpha-3 SYDC_MOUSE Aspartate--tRNA ligase, cytoplasmic H15_MOUSE Histone H1.5 SMRC2_MOUSE SWI/SNF complex subunit SMARCC2 NAA50_MOUSE Isoform 2 of N-alpha-acetyltransferase 50 DRS7B_MOUSE Dehydrogenase/reductase SDR family member 7B RS24_MOUSE 40S ribosomal protein S24 FKBP2_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP2 CSK2B_MOUSE Casein kinase II subunit beta NTKL_MOUSE N-terminal kinase-like protein SRSF6_MOUSE Serine/arginine-rich splicing factor 6 DLG1_MOUSE Disks large homolog 1 FLOT2_MOUSE Flotillin-2 AIFM2_MOUSE Apoptosis-inducing factor 2 NFS1_MOUSE Cysteine desulfurase, mitochondrial SIL1_MOUSE Nucleotide exchange factor SIL1
EP
Hp Sfpq Atp1a2 Csrp1 Tecr Hspg2 Rpl12 Pfkm S100a10 Amacr Tmem120a Rab3gap2 Mccc2 Arfgap2 Dhtkd1 Mecr Baz1b S100a6 Ppfibp1 Psmd8 Nsf Nup88 Lima1 Dnajc13 Mrpl41 Lactb Arfgap3 Rab3gap1 Pcna Gmds Gar1 Nup50 Coasy Rhot1 Timm10 Mta2 Uba6 Hmox2 Aldh3a2 Iscu Dnajb11 Acp1 Ahcyl1 Timm9 Psmd13 Samm50 Kpna4 Dars Hist1h1b Smarcc2 Naa50 Dhrs7b Rps24 Fkbp2 Csnk2b Scyl1 Srsf6 Dlg1 Flot2 Aifm2 Nfs1 Sil1
AC C
sp|Q61646|HPT_MOUSE sp|Q8VIJ6|SFPQ_MOUSE sp|Q6PIE5|AT1A2_MOUSE sp|P97315|CSRP1_MOUSE sp|Q9CY27|TECR_MOUSE sp|Q05793|PGBM_MOUSE sp|P35979|RL12_MOUSE sp|P47857|K6PF_MOUSE sp|P08207|S10AA_MOUSE sp|O09174|AMACR_MOUSE sp|Q8C1E7|T120A_MOUSE sp|Q8BMG7|RBGPR_MOUSE sp|Q3ULD5|MCCB_MOUSE sp|Q99K28|ARFG2_MOUSE sp|A2ATU0|DHTK1_MOUSE sp|Q9DCS3|MECR_MOUSE sp|Q9Z277|BAZ1B_MOUSE sp|P14069|S10A6_MOUSE sp|Q8C8U0|LIPB1_MOUSE sp|Q9CX56|PSMD8_MOUSE sp|P46460|NSF_MOUSE sp|Q8CEC0|NUP88_MOUSE sp|Q9ERG0|LIMA1_MOUSE tr|G3X922|G3X922_MOUSE sp|Q9CQN7|RM41_MOUSE sp|Q9EP89|LACTB_MOUSE sp|Q9D8S3|ARFG3_MOUSE sp|Q80UJ7|RB3GP_MOUSE sp|P17918|PCNA_MOUSE sp|Q8K0C9|GMDS_MOUSE sp|Q9CY66|GAR1_MOUSE sp|Q9JIH2|NUP50_MOUSE sp|Q9DBL7|COASY_MOUSE sp|Q8BG51|MIRO1_MOUSE sp|P62073|TIM10_MOUSE sp|Q9R190|MTA2_MOUSE sp|Q8C7R4|UBA6_MOUSE sp|O70252|HMOX2_MOUSE sp|P47740|AL3A2_MOUSE sp|Q9D7P6|ISCU_MOUSE sp|Q99KV1|DJB11_MOUSE sp|Q9D358|PPAC_MOUSE sp|Q80SW1|SAHH2_MOUSE sp|Q9WV98|TIM9_MOUSE sp|Q9WVJ2|PSD13_MOUSE sp|Q8BGH2|SAM50_MOUSE sp|O35343|IMA3_MOUSE sp|Q922B2|SYDC_MOUSE sp|P43276|H15_MOUSE sp|Q6PDG5|SMRC2_MOUSE sp|Q6PGB6-2|NAA50_MOUSE sp|Q99J47|DRS7B_MOUSE sp|P62849|RS24_MOUSE sp|P45878|FKBP2_MOUSE sp|P67871|CSK2B_MOUSE sp|Q9EQC5|NTKL_MOUSE sp|Q3TWW8|SRSF6_MOUSE sp|Q811D0|DLG1_MOUSE sp|Q60634|FLOT2_MOUSE sp|Q8BUE4|AIFM2_MOUSE sp|Q9Z1J3|NFS1_MOUSE sp|Q9EPK6|SIL1_MOUSE
758.63 1392.79 448.325 281.707 671.893 481.44 421.676 466.45 501.127 494.283 597.81 483.617 389.076 325.491 581.745 454.013 613.006 644.263 585.261 766.508 610.956 505.86 571.509 515.988 507.509 707.968 331.529 705.126 634.767 587.813 489.744 554.901 728.704 570.708 779.004 530.538 457.171 367.28 459.589 496.73 637.997 267.326 422.403 498.559 465.434 392.462 257.309 629.496 348.643 466.968 406.693 459.544 908.896 599.73 454.033 459.169 396.084 395.575 316.12 395.544 331.365 479.335
307.929 1372 540.318 747.046 523.394 435.38 696.876 753.162 273.357 602.523 850.459 576.631 495.386 236.453 366.124 507.246 365.014 605.552 517.343 881.858 694.192 797.712 660.654 479.407 184.407 385.445 402.317 657.4 614.859 628.173 460.617 638.373 540.271 936.307 563.209 607.162 765.685 400.985 662.018 340.912 625.256 964.914 486.269 473.842 925.153 1056.87 597.326 730.038 1114.28 744.633 481.076 444.891 887.515 487.763 490.5 1000.1 258.557 480.353 455.217 497.769 264.545 424.773
984.945 1282.17 465.496 1359.86 571.698 489.609 724.401 563.608 323.295 574.636 569.93 457.422 660.235 508.992 520.353 641.797 295.657 756.454 855.372 526.679 551.504 572.191 1050.9 427.473 581.803 502.604 485.452 597.489 952.393 502.446 461.559 1110.95 617.948 636.188 1235.56 589.433 474.379 474.981 454.309 1404.99 820.542 1818.17 446.404 932.59 628.423 675.245 557.766 503.717 704.2 1109.16 570.649 415.602 1055.66 1003.35 609.448 832.647 715.265 780.343 531.744 557.072 530.301 411.246
1.41 1.41 1.39 1.37 1.35 1.34 1.33 1.30 1.29 1.27 1.27 1.27 1.24 1.23 1.23 1.22 1.22 1.21 1.20 1.20 1.20 1.19 1.18 1.18 1.18 1.17 1.16 1.15 1.14 1.14 1.14 1.14 1.13 1.12 1.12 1.11 1.10 1.09 1.09 1.09 1.08 1.08 1.08 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.04 1.03
1.23 1.67 1.36 4.17 0.97 1.09 2.19 1.63 0.59 1.41 1.28 1.23 1.47 1.16 0.85 1.49 0.58 1.44 1.32 0.96 1.17 1.42 1.87 0.95 0.78 0.70 1.30 0.91 1.58 1.21 0.98 1.68 0.76 1.37 1.31 1.20 1.32 1.20 1.20 1.55 1.11 4.75 1.00 1.34 1.77 2.24 2.21 0.96 2.21 1.91 1.25 0.93 1.16 1.24 1.26 1.83 1.18 1.34 1.43 1.38 1.12 0.85
ACCEPTED MANUSCRIPT
Trmt10c Atpaf1 Thop1 Ubfd1 Add3 Ubqln1 Anp32e Nap1l4 Luc7l3 Zranb2 Atp2b1 Ifi204 Myo6 Epb41l3 Sec22b Nsdhl Vwa5a
430.82 374.812 453.459 490.495 738.976 589.315 447.971 456.037 545.155 340.106 439.105 397.691 649.576 804.485 623.472 653.798 517.84 375.223 322.443 659.554 460.901 380.167 453.632 385.546 489.774 496.881 307.3 673.261 397.591 545.383 601.986 520.393 390.314 793.941 418.985 510.04 319.021 452.339 518.395 799.518 626.322 428.709 634.14 562.13 457.487 501.689 544.49 548.33 575.284 465.276 728.452 434.006 404.914 403.916 675.976 370.366 238.108 371.355 426.364 512.186 525.042 447.479
447.11 473.49 552.6 646.108 729.857 506.118 446.41 439.887 680.38 359.6 433.005 544.677 620.075 734.175 607.239 625.951 491.537 401.505 391.253 456.746 465.479 418.301 423.615 410.477 369.813 581.598 304.246 685.748 458.151 619.517 644.044 486.821 379.183 766.173 404.397 480.158 344.073 421.708 438.545 674.814 697.74 398.798 658.564 552.839 426.74 521.253 494.876 591.68 510.146 539.152 701.784 373.685 332.823 346.732 391.281 612.472 366.426 621.49 614.445 730.685 744.532 714.864
RI PT
393.103 476.187 565.174 608.71 582.495 459.925 373.707 396.994 674.35 310.455 410.494 538.757 503.619 714.031 545.474 553.518 421.009 393.099 434.204 366.769 379.445 404.414 519.889 470.534 416.176 620.359 274.019 700.869 461.331 682.274 716.218 451.14 371.483 743.953 399.198 471.306 376.239 440.066 445.733 631.902 790.179 424.419 766.34 631.497 571.055 555.608 582.853 710.986 527.303 615.495 681.97 385.325 359.328 424.179 545.054 428.636 256.962 386.302 484.156 494.852 528.764 528.547
SC
10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 9 9 9 9 9 9 9
M AN U
TE D
Stam2 Naga Ppm1a Snrpd3 Fkbp5
DNJC2_MOUSE DnaJ homolog subfamily C member 2 SPT6H_MOUSE Transcription elongation factor SPT6 SEPT6_MOUSE Septin-6 ZNT9_MOUSE Zinc transporter 9 MTPN_MOUSE Myotrophin BOLA3_MOUSE BolA-like protein 3 TTC1_MOUSE Tetratricopeptide repeat protein 1 ZPR1_MOUSE Zinc finger protein ZPR1 CLPB_MOUSE Caseinolytic peptidase B protein homolog CANB1_MOUSE Calcineurin subunit B type 1 PCNP_MOUSE PEST proteolytic signal-containing nuclear protein PUR4_MOUSE Phosphoribosylformylglycinamidine synthase RANG_MOUSE Ran-specific GTPase-activating protein AKT2_MOUSE RAC-beta serine/threonine-protein kinase SNP29_MOUSE Synaptosomal-associated protein 29 GMFB_MOUSE Glia maturation factor beta GOGA4_MOUSE Golgin subfamily A member 4 E9QKT1_MOUSE Ubiquitin-protein ligase E3A SPT5H_MOUSE Transcription elongation factor SPT5 SWI5_MOUSE DNA repair protein SWI5 homolog NUP62_MOUSE Nuclear pore glycoprotein p62 B7ZC46_MOUSE Septin-8 NONO_MOUSE Non-POU domain-containing octamer-binding protein PR40A_MOUSE Pre-mRNA-processing factor 40 homolog A SPD2A_MOUSE SH3 and PX domain-containing protein 2A PGM2_MOUSE Phosphoglucomutase-2 NFU1_MOUSE NFU1 iron-sulfur cluster scaffold homolog, mitochondrial PUF60_MOUSE Poly(U)-binding-splicing factor PUF60 SNX9_MOUSE Sorting nexin-9 ARL8A_MOUSE ADP-ribosylation factor-like protein 8A ILF2_MOUSE Interleukin enhancer-binding factor 2 CDC26_MOUSE Anaphase-promoting complex subunit CDC26 DNJC7_MOUSE DnaJ homolog subfamily C member 7 FUT11_MOUSE Alpha-(1,3)-fucosyltransferase 11 PP4R2_MOUSE Serine/threonine-protein phosphatase 4 regulatory subunit 2 CLIC1_MOUSE Chloride intracellular channel protein 1 ARPC3_MOUSE Actin-related protein 2/3 complex subunit 3 CASP8_MOUSE Caspase-8 CF203_MOUSE Uncharacterized protein C6orf203 homolog STAM2_MOUSE Signal transducing adapter molecule 2 NAGAB_MOUSE Alpha-N-acetylgalactosaminidase PPM1A_MOUSE Protein phosphatase 1A SMD3_MOUSE Small nuclear ribonucleoprotein Sm D3 FKBP5_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP5 CB047_MOUSE Uncharacterized protein C2orf47 homolog, mitochondrial MRRP1_MOUSE Mitochondrial ribonuclease P protein 1 ATPF1_MOUSE ATP synthase mitochondrial F1 complex assembly factor 1 THOP1_MOUSE Thimet oligopeptidase UBFD1_MOUSE Ubiquitin domain-containing protein UBFD1 ADDG_MOUSE Isoform 1 of Gamma-adducin UBQL1_MOUSE Ubiquilin-1 AN32E_MOUSE Acidic leucine-rich nuclear phosphoprotein 32 family member E NP1L4_MOUSE Nucleosome assembly protein 1-like 4 LC7L3_MOUSE Luc7-like protein 3 ZRAB2_MOUSE Zinc finger Ran-binding domain-containing protein 2 G5E829_MOUSE MCG13663, isoform CRA_a IFI4_MOUSE Interferon-activable protein 204 E9PVU0_MOUSE Unconventional myosin-VI E41L3_MOUSE Isoform 3 of Band 4.1-like protein 3 SC22B_MOUSE Vesicle-trafficking protein SEC22b NSDHL_MOUSE Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating VMA5A_MOUSE von Willebrand factor A domain-containing protein 5A
EP
Dnajc2 Supt6h Septin6 Slc30a9 Mtpn Bola3 Ttc1 Zpr1 Clpb Ppp3r1 Pcnp Pfas Ranbp1 Akt2 Snap29 Gmfb Golga4 Ube3a Supt5h Swi5 Nup62 septin8 Nono Prpf40a Sh3pxd2a Pgm2 Nfu1 Puf60 Snx9 Arl8a Ilf2 Cdc26 Dnajc7 Fut11 Ppp4r2 Clic1 Arpc3 Casp8
AC C
sp|P54103|DNJC2_MOUSE sp|Q62383|SPT6H_MOUSE sp|Q9R1T4|SEPT6_MOUSE sp|Q5IRJ6|ZNT9_MOUSE sp|P62774|MTPN_MOUSE sp|Q8CEI1|BOLA3_MOUSE sp|Q91Z38|TTC1_MOUSE sp|Q62384|ZPR1_MOUSE sp|Q60649|CLPB_MOUSE sp|Q63810|CANB1_MOUSE sp|Q6P8I4|PCNP_MOUSE sp|Q5SUR0|PUR4_MOUSE sp|P34022|RANG_MOUSE sp|Q60823|AKT2_MOUSE sp|Q9ERB0|SNP29_MOUSE sp|Q9CQI3|GMFB_MOUSE sp|Q91VW5|GOGA4_MOUSE tr|E9QKT1|E9QKT1_MOUSE sp|O55201|SPT5H_MOUSE sp|Q8K3D3|SWI5_MOUSE sp|Q63850|NUP62_MOUSE tr|B7ZC46|B7ZC46_MOUSE sp|Q99K48|NONO_MOUSE sp|Q9R1C7|PR40A_MOUSE sp|O89032|SPD2A_MOUSE sp|Q7TSV4|PGM2_MOUSE sp|Q9QZ23|NFU1_MOUSE sp|Q3UEB3|PUF60_MOUSE sp|Q91VH2|SNX9_MOUSE sp|Q8VEH3|ARL8A_MOUSE sp|Q9CXY6|ILF2_MOUSE sp|Q99JP4|CDC26_MOUSE sp|Q9QYI3|DNJC7_MOUSE sp|Q8BHC9|FUT11_MOUSE sp|Q0VGB7|PP4R2_MOUSE sp|Q9Z1Q5|CLIC1_MOUSE sp|Q9JM76|ARPC3_MOUSE sp|O89110|CASP8_MOUSE sp|Q9CQF4|CF203_MOUSE sp|O88811|STAM2_MOUSE sp|Q9QWR8|NAGAB_MOUSE sp|P49443|PPM1A_MOUSE sp|P62320|SMD3_MOUSE sp|Q64378|FKBP5_MOUSE sp|Q8BHE8|CB047_MOUSE sp|Q3UFY8|MRRP1_MOUSE sp|Q811I0|ATPF1_MOUSE sp|Q8C1A5|THOP1_MOUSE sp|Q78JW9|UBFD1_MOUSE sp|Q9QYB5-2|ADDG_MOUSE sp|Q8R317|UBQL1_MOUSE sp|P97822|AN32E_MOUSE sp|Q78ZA7|NP1L4_MOUSE sp|Q5SUF2|LC7L3_MOUSE sp|Q9R020|ZRAB2_MOUSE tr|G5E829|G5E829_MOUSE sp|P15092|IFI4_MOUSE tr|E9PVU0|E9PVU0_MOUSE sp|Q9WV92-3|E41L3_MOUSE sp|O08547|SC22B_MOUSE sp|Q9R1J0|NSDHL_MOUSE sp|Q99KC8|VMA5A_MOUSE
398.155 399.09 482.192 461.462 598.811 546.811 375.856 412.856 535.373 288.507 410.885 384.149 521.566 765.699 544.622 559.635 429.701 351.771 350.511 539.931 347.655 339.99 511.983 410.772 498.67 488.507 252.395 629.163 363.089 552.959 594.344 423.377 334.495 666.236 356.913 425.568 297.601 400.33 447.313 633.471 593.734 377.184 609.253 518.077 484.864 409.374 496.813 513.059 447.898 393.516 499.162 299.788 286.591 286.11 489.736 511.038 328.511 404.957 599.94 609.466 651.778 573.477
508.076 352.05 377.049 742.86 552.461 337.112 337.75 397.341 546.913 349.547 179.093 521.347 547.411 704.427 257.147 598.417 330.177 452.774 331.049 193.141 545.078 339.125 602.395 513.588 804.507 596.496 318.92 632.409 656.146 667.574 559.282 183.184 412.044 421.508 258.177 729.02 1087.48 1137.54 405.776 577.972 648.341 547.628 543.271 954.74 587.911 390.386 279.547 666.939 346.752 401.458 510.68 456.962 559.69 413.041 792.224 453.548 938.731 526.837 525.515 660.67 351.077 551.489
668.691 358.07 438.076 474.211 1156.39 1186.93 554.338 907.231 755.922 786.051 453.923 387.824 1116.97 718.26 888.136 1330.63 748.557 371.702 339.738 529.052 941.667 463.86 484.192 657.026 919.946 464.961 630.541 907.204 603.867 501.042 520.186 502.01 699.755 677.244 453.509 608.345 728.369 2252.8 758.683 1209.77 392.784 1273.92 793.093 968.2 996.93 352.865 559.952 652.49 684.868 462.255 1479.67 698.467 1135.75 605.079 1898.82 345.654 1094.88 570.789 474.785 471.431 310.551 412.186
1.03 1.03 1.02 1.01 1.01 1.00 1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.94 0.94 0.94 0.93 0.93 0.92 0.92 0.92 0.92 0.91 0.91 0.91 0.91 0.90 0.89 0.88 0.88 0.88 0.87 0.86 0.85 0.82 0.81 0.76 0.72 1.41 1.40 1.35 1.33 1.33 1.33 1.32
1.43 0.83 0.80 1.11 1.29 1.45 1.09 1.53 1.07 1.75 0.75 0.97 1.44 0.94 0.98 1.60 1.15 1.07 0.89 0.70 1.77 1.02 1.12 1.37 1.90 0.95 1.63 1.12 1.47 0.95 0.82 0.71 1.46 0.71 0.87 1.36 2.61 3.80 1.21 1.25 0.73 2.14 0.95 1.61 1.54 0.70 0.74 1.05 0.94 0.80 1.41 1.41 2.22 1.23 2.20 1.00 4.11 1.45 1.10 1.12 0.63 0.99
ACCEPTED MANUSCRIPT
TE D
223.22 319.961 432.024 476.645 570.977 416.791 494.201 267.573 509.722 545.018 366.224 294.715 663.613 382.978 334.678 468.788 286.234 511.02 325.386 598.594 377.294 247.369 424.655 378.314 549.098 620.702 405.968 279.929 382.829 374.559 281.373 414.956 467.372 306.545 564.931 232.082 332.163 494.814 296.174 541.319 384.584 250.937 573.642 383.475 592.287 416.363 276.655 398.967 556.592 348.03 477.216 406.683 578.479 411.739 260.82 544.229 376.805 424.562 412.09 422.901 463.735 634.725
362.486 558.669 642.361 741.05 809.791 704.028 604.437 400.226 737.035 574.751 408.083 381.892 825.979 546.701 456.467 637.332 334.183 673.237 419.135 881.806 513.138 309.957 466.309 504.028 329.798 855.971 515.062 397.022 507.425 448.955 369.647 556.981 549.406 357.842 593.956 284.156 390.573 541.469 379.978 739.305 464.163 344.902 651.925 501.293 718.273 557.616 346.828 503.434 623.841 448.598 523.662 486.862 718.419 447.304 362.508 584.758 429.74 451.702 457.986 484.837 584.595 809.503
RI PT
273.29 431.856 463.981 555.871 696.266 532.301 451.696 323.926 569.246 468.54 331.998 331.257 626.198 412.622 381.227 498.002 228.912 561.295 323.357 712.435 376.199 241.592 383.05 416.199 347.547 668.164 401.559 336.815 445.092 465.078 312.186 485.568 482.63 333.267 454.42 270.955 349.609 538.317 305.847 640.794 396.928 295.178 529.473 384.918 629.534 461.817 288.262 441.64 533.345 388.735 567.413 458.684 674.274 361.97 324.673 503.277 405.124 449.305 481.148 447.682 555.499 680.282
SC
9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
M AN U
GSH1_MOUSE Glutamate--cysteine ligase catalytic subunit NDUBB_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial H10_MOUSE Histone H1.0 SMHD1_MOUSE Structural maintenance of chromosomes flexible hinge domain-containing protein 1 CD63_MOUSE CD63 antigen GSTA4_MOUSE Glutathione S-transferase A4 PGK2_MOUSE Phosphoglycerate kinase 2 COX41_MOUSE Cytochrome c oxidase subunit 4 isoform 1, mitochondrial TEFM_MOUSE Transcription elongation factor, mitochondrial CS010_MOUSE UPF0556 protein C19orf10 homolog AP2A1_MOUSE AP-2 complex subunit alpha-1 SE1L1_MOUSE Protein sel-1 homolog 1 CNOT1_MOUSE CCR4-NOT transcription complex subunit 1 MAVS_MOUSE Mitochondrial antiviral-signaling protein SSRG_MOUSE Translocon-associated protein subunit gamma Q8BVY0_MOUSE Protein Rsl1d1 TACO1_MOUSE Translational activator of cytochrome c oxidase 1 CAB39_MOUSE Calcium-binding protein 39 FIS1_MOUSE Mitochondrial fission 1 protein UFSP2_MOUSE Ufm1-specific protease 2 RHOC_MOUSE Rho-related GTP-binding protein RhoC SBDS_MOUSE Ribosome maturation protein SBDS TBC8B_MOUSE TBC1 domain family member 8B ANXA3_MOUSE Annexin A3 D3YYM6_MOUSE 40S ribosomal protein S5 (Fragment) ILK_MOUSE Integrin-linked protein kinase PDLI1_MOUSE PDZ and LIM domain protein 1 ECHD3_MOUSE Enoyl-CoA hydratase domain-containing protein 3, mitochondrial PPP5_MOUSE Serine/threonine-protein phosphatase 5 UD16_MOUSE UDP-glucuronosyltransferase 1-6 IMPA3_MOUSE Inositol monophosphatase 3 ESYT2_MOUSE Extended synaptotagmin-2 MTA3_MOUSE Metastasis-associated protein MTA3 QIL1_MOUSE Protein QIL1 LYPA2_MOUSE Acyl-protein thioesterase 2 HNRLL_MOUSE Heterogeneous nuclear ribonucleoprotein L-like PP6R3_MOUSE Serine/threonine-protein phosphatase 6 regulatory subunit 3 ARF6_MOUSE ADP-ribosylation factor 6 HIP1_MOUSE Huntingtin-interacting protein 1 PTBP3_MOUSE Polypyrimidine tract-binding protein 3 ELAV1_MOUSE ELAV-like protein 1 EFTS_MOUSE Elongation factor Ts, mitochondrial RM40_MOUSE 39S ribosomal protein L40, mitochondrial CLPP_MOUSE ATP-dependent Clp protease proteolytic subunit, mitochondrial HSP7E_MOUSE Heat shock 70 kDa protein 14 TIPRL_MOUSE TIP41-like protein GGA1_MOUSE ADP-ribosylation factor-binding protein GGA1 BAG5_MOUSE BAG family molecular chaperone regulator 5 ABCF2_MOUSE ATP-binding cassette sub-family F member 2 CCAR1_MOUSE Cell division cycle and apoptosis regulator protein 1 RL15_MOUSE 60S ribosomal protein L15 EH1L1_MOUSE EH domain-binding protein 1-like protein 1 LMAN2_MOUSE Vesicular integral-membrane protein VIP36 TXD12_MOUSE Thioredoxin domain-containing protein 12 LAP2B_MOUSE Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma NP1L1_MOUSE Nucleosome assembly protein 1-like 1 ADK_MOUSE Adenosine kinase P4HA2_MOUSE Isoform IIa of Prolyl 4-hydroxylase subunit alpha-2 BNIP3_MOUSE BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 PHS2_MOUSE Pterin-4-alpha-carbinolamine dehydratase 2 DNJC3_MOUSE DnaJ homolog subfamily C member 3 IAH1_MOUSE Isoamyl acetate-hydrolyzing esterase 1 homolog
EP
Gclc Ndufb11 H1f0 Smchd1 Cd63 Gsta4 Pgk2 Cox4i1 Tefm D17Wsu104e Ap2a1 Sel1l Cnot1 Mavs Ssr3 Rsl1d1 Taco1 Cab39 Fis1 Ufsp2 Rhoc Sbds Tbc1d8b Anxa3 Rps5 Ilk Pdlim1 Echdc3 Ppp5c Ugt1a6 Impad1 Esyt2 Mta3 Qil1 Lypla2 Hnrnpll Ppp6r3 Arf6 Hip1 Ptbp3 Elavl1 Tsfm Mrpl40 Clpp Hspa14 Tiprl Gga1 Bag5 Abcf2 Ccar1 Rpl15 Ehbp1l1 Lman2 Txndc12 Tmpo Nap1l1 Adk P4ha2 Bnip3 Pcbd2 Dnajc3 Iah1
AC C
sp|P97494|GSH1_MOUSE sp|O09111|NDUBB_MOUSE sp|P10922|H10_MOUSE sp|Q6P5D8|SMHD1_MOUSE sp|P41731|CD63_MOUSE sp|P24472|GSTA4_MOUSE sp|P09041|PGK2_MOUSE sp|P19783|COX41_MOUSE sp|Q5SSK3|TEFM_MOUSE sp|Q9CPT4|CS010_MOUSE sp|P17426|AP2A1_MOUSE sp|Q9Z2G6|SE1L1_MOUSE sp|Q6ZQ08|CNOT1_MOUSE sp|Q8VCF0|MAVS_MOUSE sp|Q9DCF9|SSRG_MOUSE tr|Q8BVY0|Q8BVY0_MOUSE sp|Q8K0Z7|TACO1_MOUSE sp|Q06138|CAB39_MOUSE sp|Q9CQ92|FIS1_MOUSE sp|Q99K23|UFSP2_MOUSE sp|Q62159|RHOC_MOUSE sp|P70122|SBDS_MOUSE sp|A3KGB4|TBC8B_MOUSE sp|O35639|ANXA3_MOUSE tr|D3YYM6|D3YYM6_MOUSE sp|O55222|ILK_MOUSE sp|O70400|PDLI1_MOUSE sp|Q9D7J9|ECHD3_MOUSE sp|Q60676|PPP5_MOUSE sp|Q64435|UD16_MOUSE sp|Q80V26|IMPA3_MOUSE sp|Q3TZZ7|ESYT2_MOUSE sp|Q924K8|MTA3_MOUSE sp|Q8R404|QIL1_MOUSE sp|Q9WTL7|LYPA2_MOUSE sp|Q921F4|HNRLL_MOUSE sp|Q922D4|PP6R3_MOUSE sp|P62331|ARF6_MOUSE sp|Q8VD75|HIP1_MOUSE sp|Q8BHD7|PTBP3_MOUSE sp|P70372|ELAV1_MOUSE sp|Q9CZR8|EFTS_MOUSE sp|Q9Z2Q5|RM40_MOUSE sp|O88696|CLPP_MOUSE sp|Q99M31|HSP7E_MOUSE sp|Q8BH58|TIPRL_MOUSE sp|Q8R0H9|GGA1_MOUSE sp|Q8CI32|BAG5_MOUSE sp|Q99LE6|ABCF2_MOUSE sp|Q8CH18|CCAR1_MOUSE sp|Q9CZM2|RL15_MOUSE sp|Q99MS7|EH1L1_MOUSE sp|Q9DBH5|LMAN2_MOUSE sp|Q9CQU0|TXD12_MOUSE sp|Q61029|LAP2B_MOUSE sp|P28656|NP1L1_MOUSE sp|P55264|ADK_MOUSE sp|Q60716-2|P4HA2_MOUSE sp|O55003|BNIP3_MOUSE sp|Q9CZL5|PHS2_MOUSE sp|Q91YW3|DNJC3_MOUSE sp|Q9DB29|IAH1_MOUSE
289.477 416.869 515.592 568.142 787.677 484.406 579.641 335.316 587.853 664.572 438.611 375.016 730.869 411.243 405.06 522.904 279.66 599.745 349.745 666.202 373.705 261.983 475.87 417.538 709.599 629.347 412.548 310.785 434.905 503.791 296.978 453.31 514.724 356.013 541.229 270.628 361.055 594.495 279.049 554.592 389.171 250.654 549.368 328.6 595.509 386.121 259.204 397.865 537.309 333.71 572.135 419.488 587.409 358.8 246.458 497.363 373.374 434.032 446.53 394.957 442.919 513.569
406.467 337.431 1009.22 651.974 460.013 631.21 749.717 435.491 317.086 495.136 1163.22 307.272 762.285 292.079 453.871 509.927 576.442 528.278 398.14 834.392 1602.63 942.486 574.013 873.493 827.418 662.492 561.833 299.972 556.515 361.589 476.612 559.056 632.443 327.256 972.489 1354.55 889.074 685.335 358.067 601.732 428.957 515.32 219.452 364.383 1048.22 709.284 365.111 344.548 639.815 491.335 465.407 312.34 565.704 291.754 641.858 641.538 500.512 583.597 430.252 466.748 330.93 349.762
308.469 242.548 622.812 533.242 314.165 662.711 554.059 350.034 341.5 487.207 838.914 223.501 580.915 361.506 347.895 372.541 1593.92 458.557 353.744 609.518 1296.97 852.627 555.344 780.807 519.734 715.323 918.1 486.881 441.125 398.13 338.067 396.102 778.105 461.902 1723.93 1145.17 689.757 488.676 403.259 672.06 418.564 1185.92 744.994 435.107 833.747 569.152 505.093 280.761 549.449 654.37 399.782 487.033 559.145 570.12 651.763 1086.78 451.827 461.849 493.683 1022.69 374.445 781.798
1.31 1.30 1.29 1.27 1.26 1.25 1.25 1.24 1.23 1.22 1.21 1.21 1.21 1.20 1.20 1.20 1.19 1.19 1.19 1.18 1.18 1.17 1.17 1.16 1.16 1.15 1.15 1.15 1.14 1.13 1.12 1.12 1.12 1.12 1.11 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09 1.08 1.08 1.07 1.07 1.07 1.07 1.06 1.05 1.05 1.04 1.04 1.04 1.03 1.03 1.01 1.01 1.01 1.01 1.01
1.44 0.77 1.82 1.15 0.61 1.36 1.38 1.33 0.61 0.97 2.87 0.85 1.04 0.82 1.12 0.91 4.21 0.92 1.16 1.10 3.85 3.67 1.40 2.08 1.50 1.07 1.83 1.28 1.20 0.90 1.37 1.06 1.48 1.23 2.65 4.97 2.32 1.14 1.26 1.08 1.08 3.12 0.87 1.04 1.54 1.46 1.54 0.74 1.09 1.56 0.83 0.92 0.90 1.11 2.21 1.65 1.22 1.20 1.03 1.71 0.69 0.86
ACCEPTED MANUSCRIPT
TE D
478.67 463.01 648.119 607.715 736.681 410.11 259.985 315.998 447.997 415.876 371.991 453.049 359.536 351.365 488.833 430.067 625.72 476.643 389.478 495.592 355.333 758.999 572.161 318.457 361.258 421.93 384.189 957.298 297.614 552.82 486.504 605.561 447.491 453.638 297.51 390.981 825.739 292.828 475.044 456.092 386.187 465.902 448.788 699.084 742.695 674.39 451.908 712.51 134.78 403.014 229.467 291.082 555.789 515.307 352.082 286.768 367.907 270.894 271.764 335.959 401.363 354.326
535.686 602.719 720.56 719.758 846.46 396.506 349.541 373.886 449.744 402.159 417.511 503.319 361.521 435.352 569.866 476.436 646.699 535.573 379.999 508.708 365.897 798.229 595.936 336.903 343.744 462.34 402.364 942.242 330.124 532.891 496.106 626.782 425.179 424.293 311.65 330.482 568.303 284.958 462.562 408.073 360.026 304.19 397.998 440.389 647.541 477.221 369.79 924.409 267.564 684.928 353.134 473.426 737.56 861.154 552.212 456.3 654.912 603.448 490.825 425.205 626.31 530
RI PT
507.759 580.844 788.827 660.226 706.407 349.15 334.983 414.455 477.243 359.574 478.126 491.354 351.706 448.429 600.243 454.856 613.003 489.879 363.674 455.003 355.696 667.052 568.664 323.939 331.815 531.481 412.392 868.062 361.897 491.739 508.948 607.903 497.207 453.554 344.362 345.047 561.385 361.825 474.228 545.627 386.423 407.457 487.426 441.436 797.677 604.268 435.287 506.871 163.098 367.007 247.837 313.883 445.509 443.093 374.81 297.927 429.19 419.196 331.422 292.333 389.689 426.926
SC
9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
M AN U
RAB9A_MOUSE Ras-related protein Rab-9A RRF2M_MOUSE Ribosome-releasing factor 2, mitochondrial TPMT_MOUSE Thiopurine S-methyltransferase UCHL5_MOUSE Isoform 2 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 NEDD8_MOUSE NEDD8 TBCA_MOUSE Tubulin-specific chaperone A NDUA2_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 MPC2_MOUSE Mitochondrial pyruvate carrier 2 FACE1_MOUSE CAAX prenyl protease 1 homolog A2AJ72_MOUSE MCG130458 SAHH3_MOUSE Putative adenosylhomocysteinase 3 H1BP3_MOUSE HCLS1-binding protein 3 SLIRP_MOUSE SRA stem-loop-interacting RNA-binding protein, mitochondrial RCC1_MOUSE Regulator of chromosome condensation KHDR1_MOUSE KH domain-containing, RNA-binding, signal transduction-associated protein 1 HPRT_MOUSE Hypoxanthine-guanine phosphoribosyltransferase ACINU_MOUSE Apoptotic chromatin condensation inducer in the nucleus FAM21_MOUSE WASH complex subunit FAM21 PFD2_MOUSE Prefoldin subunit 2 MYCBP_MOUSE C-Myc-binding protein LSM7_MOUSE U6 snRNA-associated Sm-like protein LSm7 RD23B_MOUSE UV excision repair protein RAD23 homolog B LSM4_MOUSE U6 snRNA-associated Sm-like protein LSm4 ARPC5_MOUSE Actin-related protein 2/3 complex subunit 5 Q923F1_MOUSE Chloride channel, nucleotide-sensitive, 1A RMXL1_MOUSE RNA binding motif protein, X-linked-like-1 LYPA1_MOUSE Acyl-protein thioesterase 1 Q9DCC5_MOUSE Cbx3 protein SAFB1_MOUSE Scaffold attachment factor B1 NUCB2_MOUSE Nucleobindin-2 G5E8V9_MOUSE MCG18094 (Fragment) Q9EQC8_MOUSE Papillary renal cell carcinoma (Translocation-associated) 2AAB_MOUSE Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Q9Z1A1_MOUSE Protein Tfg NUP54_MOUSE Nuclear pore complex protein Nup54 CCDC6_MOUSE Coiled-coil domain-containing protein 6 CIRBP_MOUSE Cold-inducible RNA-binding protein EIF3D_MOUSE Eukaryotic translation initiation factor 3 subunit D 2ABA_MOUSE Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform RRAGC_MOUSE Ras-related GTP-binding protein C ARP5L_MOUSE Actin-related protein 2/3 complex subunit 5-like protein ADRM1_MOUSE Proteasomal ubiquitin receptor ADRM1 NDUF7_MOUSE NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 BAG3_MOUSE BAG family molecular chaperone regulator 3 LC7L2_MOUSE Putative RNA-binding protein Luc7-like 2 PMM2_MOUSE Phosphomannomutase 2 ARGL1_MOUSE Arginine and glutamate-rich protein 1 RS10_MOUSE 40S ribosomal protein S10 CGL_MOUSE Cystathionine gamma-lyase VCAM1_MOUSE Vascular cell adhesion protein 1 F6VVY4_MOUSE Protein Slc25a1 (Fragment) NIPS2_MOUSE Protein NipSnap homolog 2 TPM4_MOUSE Tropomyosin alpha-4 chain DHRS1_MOUSE Dehydrogenase/reductase SDR family member 1 SYLM_MOUSE Probable leucine--tRNA ligase, mitochondrial CTNA1_MOUSE Catenin alpha-1 STXB3_MOUSE Syntaxin-binding protein 3 GLGB_MOUSE 1,4-alpha-glucan-branching enzyme ALAT1_MOUSE Alanine aminotransferase 1 TPM3_MOUSE Tropomyosin alpha-3 chain PSB3_MOUSE Proteasome subunit beta type-3 TBRG4_MOUSE Protein TBRG4
EP
Rab9a Gfm2 Tpmt Uchl5 Nedd8 Tbca Ndufa2 Mpc2 Zmpste24 Fubp3 Ahcyl2 Hs1bp3 Slirp Rcc1 Khdrbs1 Hprt1 Acin1 Fam21 Pfdn2 Mycbp Lsm7 Rad23b Lsm4 Arpc5 Clns1a Rbmxl1 Lypla1 Cbx3 Safb Nucb2 Arfip1 Prcc Ppp2r1b Tfg Nup54 Ccdc6 Cirbp Eif3d Ppp2r2a Rragc Arpc5l Adrm1 Ndufaf7 Bag3 Luc7l2 Pmm2 Arglu1 Rps10 Cth Vcam1 Slc25a1 Gbas Tpm4 Dhrs1 Lars2 Ctnna1 Stxbp3 Gbe1 Gpt Tpm3 Psmb3 Tbrg4
AC C
sp|Q9R0M6|RAB9A_MOUSE sp|Q8R2Q4|RRF2M_MOUSE sp|O55060|TPMT_MOUSE sp|Q9WUP7-2|UCHL5_MOUSE sp|P29595|NEDD8_MOUSE sp|P48428|TBCA_MOUSE sp|Q9CQ75|NDUA2_MOUSE sp|Q9D023|MPC2_MOUSE sp|Q80W54|FACE1_MOUSE tr|A2AJ72|A2AJ72_MOUSE sp|Q68FL4|SAHH3_MOUSE sp|Q3TC93|H1BP3_MOUSE sp|Q9D8T7|SLIRP_MOUSE sp|Q8VE37|RCC1_MOUSE sp|Q60749|KHDR1_MOUSE sp|P00493|HPRT_MOUSE sp|Q9JIX8|ACINU_MOUSE sp|Q6PGL7|FAM21_MOUSE sp|O70591|PFD2_MOUSE sp|Q9EQS3|MYCBP_MOUSE sp|Q9CQQ8|LSM7_MOUSE sp|P54728|RD23B_MOUSE sp|Q9QXA5|LSM4_MOUSE sp|Q9CPW4|ARPC5_MOUSE tr|Q923F1|Q923F1_MOUSE sp|Q91VM5|RMXL1_MOUSE sp|P97823|LYPA1_MOUSE tr|Q9DCC5|Q9DCC5_MOUSE sp|D3YXK2|SAFB1_MOUSE sp|P81117|NUCB2_MOUSE tr|G5E8V9|G5E8V9_MOUSE tr|Q9EQC8|Q9EQC8_MOUSE sp|Q7TNP2|2AAB_MOUSE tr|Q9Z1A1|Q9Z1A1_MOUSE sp|Q8BTS4|NUP54_MOUSE sp|D3YZP9|CCDC6_MOUSE sp|P60824|CIRBP_MOUSE sp|O70194|EIF3D_MOUSE sp|Q6P1F6|2ABA_MOUSE sp|Q99K70|RRAGC_MOUSE sp|Q9D898|ARP5L_MOUSE sp|Q9JKV1|ADRM1_MOUSE sp|Q9CWG8|NDUF7_MOUSE sp|Q9JLV1|BAG3_MOUSE sp|Q7TNC4|LC7L2_MOUSE sp|Q9Z2M7|PMM2_MOUSE sp|Q3UL36|ARGL1_MOUSE sp|P63325|RS10_MOUSE sp|Q8VCN5|CGL_MOUSE sp|P29533|VCAM1_MOUSE tr|F6VVY4|F6VVY4_MOUSE sp|O55126|NIPS2_MOUSE sp|Q6IRU2|TPM4_MOUSE sp|Q99L04|DHRS1_MOUSE sp|Q8VDC0|SYLM_MOUSE sp|P26231|CTNA1_MOUSE sp|Q60770|STXB3_MOUSE sp|Q9D6Y9|GLGB_MOUSE sp|Q8QZR5|ALAT1_MOUSE sp|P21107|TPM3_MOUSE sp|Q9R1P1|PSB3_MOUSE sp|Q91YM4|TBRG4_MOUSE
454.833 441.021 714.431 535.833 571.321 349.307 234.74 343.365 457.672 355.258 410.946 416.376 329.785 341.476 484.895 379.705 546.242 394.487 342.551 401.222 308.205 546.628 474.172 261.641 296.854 409.408 324.733 707.015 262.113 404.374 396.261 451.343 413.909 377.544 253.629 313.237 639.895 285.146 360.999 445.748 270.064 387.494 316.685 426.427 505.219 444.938 264.294 1348.7 259.123 634.85 439.91 495.005 856.129 486.297 458.928 354.669 443.269 337.602 331.565 416.491 406.013 482.384
458.868 518.518 436.412 784.799 495.247 410.855 264.133 863.163 367.205 467.957 931.058 206.241 193.467 517.189 927.35 467.016 355.891 302.447 386.163 282.808 317.744 578.651 459.337 448.2 242.154 279.258 436.594 668.536 423.677 185.284 459.639 347.273 327.438 408.75 354.103 333.909 441.963 886.452 459.66 657.519 316.843 778.334 212.464 432.266 567.429 653.59 386.183 977.766 622.936 182.445 974.168 1065.39 643.768 864.443 525.911 242.516 653.119 786.41 622.309 341.031 534.116 153.176
735.103 1138.39 461.618 1013.22 1033.46 923.385 408.172 806.797 407.444 970.842 930.877 234.388 387.865 450.438 1004.06 469.453 815.214 457.318 728.301 842.263 586.781 1244.01 823.974 545.762 550.854 725.374 696.546 1371.6 614.472 572.027 407.967 420.534 492.391 525.964 320.499 562.952 1006.01 843.626 555.673 580.073 546.845 1194.81 448.495 1091.84 1017.77 1270.57 747.079 701.736 565.993 250.099 589.014 1424.97 1067.36 766.87 545.365 277.888 387.466 610.37 657.438 557.512 396.726 249.908
1.00 1.00 1.00 0.99 0.98 0.98 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.95 0.94 0.94 0.93 0.92 0.91 0.91 0.90 0.90 0.90 0.90 0.89 0.89 0.88 0.88 0.87 0.87 0.87 0.87 0.85 0.82 0.79 0.76 0.76 0.75 0.72 0.71 1.86 1.77 1.71 1.66 1.60 1.59 1.41 1.39 1.39 1.38 1.36 1.36 1.34 1.31 1.30
1.21 1.59 0.62 1.42 1.06 1.76 1.13 2.29 0.84 1.86 2.19 0.47 0.82 1.21 1.77 1.06 0.95 0.79 1.48 1.18 1.27 1.28 1.12 1.55 1.14 1.05 1.42 1.12 1.57 0.73 0.87 0.63 0.87 1.03 1.05 1.22 1.04 2.64 1.07 1.24 1.12 2.26 0.71 1.34 1.03 1.50 1.28 1.38 3.99 0.56 3.28 4.12 1.71 1.70 1.47 0.89 1.31 2.02 2.12 1.43 1.18 0.52
ACCEPTED MANUSCRIPT
TE D
181.55 372.233 295.909 366.544 395.142 281.101 343.556 230.959 239.699 273.585 360.746 277.469 329.029 317.578 549.14 493.625 445.129 536.952 288.133 401.948 310.487 274.732 336.041 487.792 373.92 463.147 319.918 373.017 363.863 313.314 274.345 330.409 248.036 318.804 290.062 191.799 432.475 328.641 401.792 618.255 337.943 351.401 388.858 245.656 269.789 467.251 352.475 247.913 510.069 373.021 478.675 446.803 673.064 270.756 209.239 318.663 364.021 496.587 417.041 547.065 389.231 495.91
280.24 314.555 356.22 537.343 686.572 429.589 431.823 359.29 311.041 382.512 478.267 281.459 398.73 416.011 622.85 530.418 655.448 803.085 372.582 516.822 389.94 389.81 498.601 651.868 493.435 562.361 442.036 556.87 450.059 426.647 341.549 362.016 326.262 569.78 414.022 263.322 536.023 421.423 517.156 849.682 449.999 408.883 450.134 348.965 334.192 581.188 369.509 254.715 633.988 438.517 519.822 501.404 651.684 304.27 251.099 353.999 367.974 582.903 472.621 790.951 319.481 457.972
RI PT
195.102 269.592 269.859 371.295 494.048 304.874 311.11 274.657 251.864 292.348 393.021 241.129 294.395 289.911 508.315 403.675 546.995 640.646 277.308 440.52 317.834 346.83 391.4 539.258 402.38 447.112 372.925 468.861 369.679 338.996 289.418 382.301 293.345 533.102 373.47 235.909 480.671 425.26 477.369 778.521 374.196 366.749 364.917 288.605 287.617 513.496 329.796 211.545 574.167 436.733 465.365 405.785 567.977 316.058 225.252 323.927 452.606 522.335 428.657 738.335 281.936 408.105
SC
8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
M AN U
PDK3_MOUSE [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial NUCKS_MOUSE Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 EXOC4_MOUSE Exocyst complex component 4 TOIP1_MOUSE Torsin-1A-interacting protein 1 LANC1_MOUSE LanC-like protein 1 PO121_MOUSE Nuclear envelope pore membrane protein POM 121 COX5A_MOUSE Cytochrome c oxidase subunit 5A, mitochondrial ADAS_MOUSE Alkyldihydroxyacetonephosphate synthase, peroxisomal PDS5A_MOUSE Sister chromatid cohesion protein PDS5 homolog A SVIL_MOUSE Supervillin CUL5_MOUSE Cullin-5 ATX10_MOUSE Ataxin-10 MCTS2_MOUSE Malignant T-cell-amplified sequence 2 Q3TGS7_MOUSE Sorting nexin 12, isoform CRA_b ACYP2_MOUSE Acylphosphatase-2 EPN4_MOUSE Clathrin interactor 1 ARL8B_MOUSE ADP-ribosylation factor-like protein 8B DDHD2_MOUSE Phospholipase DDHD2 RT36_MOUSE 28S ribosomal protein S36, mitochondrial DHB11_MOUSE Estradiol 17-beta-dehydrogenase 11 MTMR5_MOUSE Myotubularin-related protein 5 OST48_MOUSE Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit KIF1B_MOUSE Kinesin-like protein KIF1B COX15_MOUSE Cytochrome c oxidase assembly protein COX15 homolog DPYL3_MOUSE Dihydropyrimidinase-related protein 3 WNK1_MOUSE Serine/threonine-protein kinase WNK1 SNRPA_MOUSE U1 small nuclear ribonucleoprotein A DYN1_MOUSE Dynamin-1 SAP3_MOUSE Ganglioside GM2 activator MK01_MOUSE Mitogen-activated protein kinase 1 MP2K2_MOUSE Dual specificity mitogen-activated protein kinase kinase 2 GSTM5_MOUSE Glutathione S-transferase Mu 5 DX39A_MOUSE ATP-dependent RNA helicase DDX39A CYTC_MOUSE Cystatin-C PP2BA_MOUSE Isoform 2 of Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform C19L1_MOUSE CWF19-like protein 1 RAB14_MOUSE Ras-related protein Rab-14 SPG7_MOUSE Paraplegin SCLY_MOUSE Selenocysteine lyase RT23_MOUSE 28S ribosomal protein S23, mitochondrial PRS10_MOUSE 26S protease regulatory subunit 10B GPD1L_MOUSE Glycerol-3-phosphate dehydrogenase 1-like protein CBR4_MOUSE Carbonyl reductase family member 4 GOGA5_MOUSE Golgin subfamily A member 5 A2AIX1_MOUSE Protein Sec16a RM39_MOUSE 39S ribosomal protein L39, mitochondrial RAB18_MOUSE Ras-related protein Rab-18 LPP_MOUSE Lipoma-preferred partner homolog RL38_MOUSE 60S ribosomal protein L38 ABCB7_MOUSE ATP-binding cassette sub-family B member 7, mitochondrial NENF_MOUSE Neudesin IBP7_MOUSE Insulin-like growth factor-binding protein 7 UBE2K_MOUSE Ubiquitin-conjugating enzyme E2 K PEX3_MOUSE Peroxisomal biogenesis factor 3 IMA4_MOUSE Importin subunit alpha-4 CCHL_MOUSE Cytochrome c-type heme lyase MTCH1_MOUSE Mitochondrial carrier homolog 1 OGFR_MOUSE Opioid growth factor receptor PHLB1_MOUSE Pleckstrin homology-like domain family B member 1 MCES_MOUSE mRNA cap guanine-N7 methyltransferase RS20_MOUSE 40S ribosomal protein S20 LYAR_MOUSE Cell growth-regulating nucleolar protein
EP
Pdk3 Nucks1 Exoc4 Tor1aip1 Lancl1 Pom121 Cox5a Agps Pds5a Svil Cul5 Atxn10 Mcts2 Snx12 Acyp2 Clint1 Arl8b Ddhd2 Mrps36 Hsd17b11 Sbf1 Ddost Kif1b Cox15 Dpysl3 Wnk1 Snrpa Dnm1 Gm2a Mapk1 Map2k2 Gstm5 Ddx39a Cst3 Ppp3ca Cwf19l1 Rab14 Spg7 Scly Mrps23 Psmc6 Gpd1l Cbr4 Golga5 Sec16a Mrpl39 Rab18 Lpp Rpl38 Abcb7 Nenf Igfbp7 Ube2k Pex3 Kpna3 Hccs Mtch1 Ogfr Phldb1 Rnmt Rps20 Lyar
AC C
sp|Q922H2|PDK3_MOUSE sp|Q80XU3|NUCKS_MOUSE sp|O35382|EXOC4_MOUSE sp|Q921T2|TOIP1_MOUSE sp|O89112|LANC1_MOUSE sp|Q8K3Z9|PO121_MOUSE sp|P12787|COX5A_MOUSE sp|Q8C0I1|ADAS_MOUSE sp|Q6A026|PDS5A_MOUSE sp|Q8K4L3|SVIL_MOUSE sp|Q9D5V5|CUL5_MOUSE sp|P28658|ATX10_MOUSE sp|Q9CQ21|MCTS2_MOUSE tr|Q3TGS7|Q3TGS7_MOUSE sp|P56375|ACYP2_MOUSE sp|Q99KN9|EPN4_MOUSE sp|Q9CQW2|ARL8B_MOUSE sp|Q80Y98|DDHD2_MOUSE sp|Q9CQX8|RT36_MOUSE sp|Q9EQ06|DHB11_MOUSE sp|Q6ZPE2|MTMR5_MOUSE sp|O54734|OST48_MOUSE sp|Q60575|KIF1B_MOUSE sp|Q8BJ03|COX15_MOUSE sp|Q62188|DPYL3_MOUSE sp|P83741|WNK1_MOUSE sp|Q62189|SNRPA_MOUSE sp|P39053|DYN1_MOUSE sp|Q60648|SAP3_MOUSE sp|P63085|MK01_MOUSE sp|Q63932|MP2K2_MOUSE sp|P48774|GSTM5_MOUSE sp|Q8VDW0|DX39A_MOUSE sp|P21460|CYTC_MOUSE sp|P63328-2|PP2BA_MOUSE sp|Q8CI33|C19L1_MOUSE sp|Q91V41|RAB14_MOUSE sp|Q3ULF4|SPG7_MOUSE sp|Q9JLI6|SCLY_MOUSE sp|Q8VE22|RT23_MOUSE sp|P62334|PRS10_MOUSE sp|Q3ULJ0|GPD1L_MOUSE sp|Q91VT4|CBR4_MOUSE sp|Q9QYE6|GOGA5_MOUSE tr|A2AIX1|A2AIX1_MOUSE sp|Q9JKF7|RM39_MOUSE sp|P35293|RAB18_MOUSE sp|Q8BFW7|LPP_MOUSE sp|Q9JJI8|RL38_MOUSE sp|Q61102|ABCB7_MOUSE sp|Q9CQ45|NENF_MOUSE sp|Q61581|IBP7_MOUSE sp|P61087|UBE2K_MOUSE sp|Q9QXY9|PEX3_MOUSE sp|O35344|IMA4_MOUSE sp|P53702|CCHL_MOUSE sp|Q791T5|MTCH1_MOUSE sp|Q99PG2|OGFR_MOUSE sp|Q6PDH0|PHLB1_MOUSE sp|Q9D0L8|MCES_MOUSE sp|P60867|RS20_MOUSE sp|Q08288|LYAR_MOUSE
206.675 501.405 362.437 397.758 427.111 301.699 380.412 264.937 291.427 311.047 437.359 342.563 349.747 312.672 629.251 528.034 512.825 581.289 291.098 464.934 340.936 332.911 341.613 532.656 401.407 486.19 351.729 403.229 380.436 308.297 291.548 429.979 274.154 374.639 319.11 209.128 468.338 402.097 437.235 663.205 318.899 366.237 360.994 223.47 260.526 465.171 357.223 233.536 516.373 419.558 472.387 393.161 649.904 306.559 198.119 308.173 473.313 462.312 392.746 522.538 364.086 462.326
373.244 80.4791 551.491 395.188 939.04 237.616 447.186 660.238 367.697 305.321 450.456 946.481 530.325 245.046 292.12 346.842 583.832 481.576 102.953 262.444 375.1 345.899 347.396 478.233 260.43 374.714 347.756 493.694 212.982 294.576 376.999 367.416 592.346 233.047 320.501 299.516 379.381 230.37 236.924 463.752 478.304 444.814 426.775 263.924 478.969 310.579 549.877 510.458 667.234 325.624 269.406 92.8478 1045.24 302.782 645.365 329.342 489.389 199.125 254.624 891.008 596.946 523.67
484.218 379.523 420.996 328.077 558.663 387.502 946.934 300.413 276.56 561.346 385.498 516.767 576.482 508.772 684.42 623.087 384.779 793.576 80.1064 279.981 457.11 282.27 411.349 460.916 308.554 672.335 637.304 413.294 449.587 266.183 471.697 376.628 330.02 425.986 273.375 321.538 395.179 282.379 419.32 607.968 552.261 483.64 723.594 367.759 608.736 517.546 432.501 1116.02 930.734 357.899 654.521 336.493 1109.34 406.181 561.466 552.982 404.931 253.227 545.824 641.94 772.255 961.905
1.29 1.27 1.27 1.27 1.25 1.25 1.24 1.23 1.23 1.23 1.21 1.20 1.20 1.20 1.18 1.18 1.18 1.18 1.17 1.17 1.16 1.16 1.16 1.15 1.15 1.15 1.15 1.14 1.13 1.13 1.12 1.11 1.11 1.11 1.10 1.10 1.10 1.09 1.09 1.08 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.05 1.05 1.05 1.04 1.03 1.03 1.03 1.03 1.02 1.02 1.02 1.02
2.28 0.72 1.72 0.98 1.68 1.07 2.13 1.90 1.31 1.53 1.11 2.82 1.78 1.24 0.92 1.08 0.98 1.08 0.32 0.64 1.32 1.01 1.04 0.91 0.73 1.15 1.42 1.08 0.90 0.86 1.51 1.04 1.70 0.77 0.90 1.45 0.85 0.68 0.75 0.77 1.45 1.29 1.53 1.18 1.95 0.84 1.44 3.54 1.47 0.84 0.98 0.50 1.74 1.21 2.78 1.37 1.10 0.44 0.95 1.19 2.04 1.64
ACCEPTED MANUSCRIPT
271.138 292.768 321.893 487.293 510.103 481.796 373.109 296.184 382.748 590.949 387.005 483.874 312.606 305.843 355.894 517.245 434.522 348.237 201.835 419.381 282.593 356.287 483.792 220.291 614.942 377.133 378.764 283.486 446.357 318.516 371.444 499.861 456.252 299.195 532.534 490.458 411.698 494.601 292.015 575.343 285.07 340.508 401.628 476.179 401.179 379.071 317.598 483.988 689.742 276.954 522.214 546.096 235.332 564.733 281.843 501.408 572.637 537.847 597.146 623.613 366.092 488.641
290.746 305.038 336.756 592.719 546.641 587.194 360.723 316.963 402.07 620.356 383.682 337.922 357.874 300.058 351.394 514.466 521.802 437.799 237.247 435.927 312.311 439.894 354.416 202.915 714.274 417.239 398.089 266.025 420.329 294.162 411.824 523.285 442.201 294.748 617.823 420.299 423.789 485.073 310.51 537.265 268.93 298.444 307.408 446.523 370.103 365.866 299.639 419.84 691.288 294.866 487.8 511.882 259.479 534.712 201.133 427.467 492.665 463.372 487.351 487.755 350.002 402.835
RI PT
311.718 285.365 317.617 538.827 583.259 531.458 320.366 306.198 359.303 699.956 365.718 324.913 367.347 343.985 408.264 475.835 525.361 420.256 251.575 455.443 332.573 498.737 424.042 238.465 709.351 425.097 431.592 257.745 389.857 271.857 396.51 459.357 422.149 303.074 649.516 428.378 448.786 490.897 326.797 501.514 300.965 378.765 275.327 513.588 418.502 366.73 307.973 433.089 663.167 350.873 490.014 542.328 331.637 540.666 259.958 486.112 767.855 498.057 592.032 489.079 480.198 546.401
SC
8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
M AN U
TE D
Pspc1 Ranbp3 Scrn3 Prkar2a Snx3 Wdr61 Vps26a Zc3h11a Ube2v1 Col4a3bp Chchd6 Hnrnpf Ccs Prkcdbp Rreb1 Ubxn7 Acyp1 Lpin1 Trip10 Rpl36 Rprd1a Hexb Dag1 Psma3 Pxn Ogdhl Tpp1
TRXR1_MOUSE Thioredoxin reductase 1, cytoplasmic DAZP1_MOUSE DAZ-associated protein 1 5NT3A_MOUSE Cytosolic 5'-nucleotidase 3A THUM1_MOUSE THUMP domain-containing protein 1 DC1L2_MOUSE Cytoplasmic dynein 1 light intermediate chain 2 IF4E_MOUSE Eukaryotic translation initiation factor 4E VASP_MOUSE Vasodilator-stimulated phosphoprotein AGFG1_MOUSE Arf-GAP domain and FG repeat-containing protein 1 DCP1A_MOUSE mRNA-decapping enzyme 1A SSRP1_MOUSE FACT complex subunit SSRP1 RL31_MOUSE 60S ribosomal protein L31 LIPL_MOUSE Lipoprotein lipase SETD3_MOUSE Histone-lysine N-methyltransferase setd3 ACAD8_MOUSE Isobutyryl-CoA dehydrogenase, mitochondrial UBA5_MOUSE Ubiquitin-like modifier-activating enzyme 5 S10AD_MOUSE Protein S100-A13 VAT1_MOUSE Synaptic vesicle membrane protein VAT-1 homolog WDR12_MOUSE Ribosome biogenesis protein WDR12 D2HDH_MOUSE D-2-hydroxyglutarate dehydrogenase, mitochondrial TFB1M_MOUSE Dimethyladenosine transferase 1, mitochondrial FLOT1_MOUSE Flotillin-1 RUVB2_MOUSE RuvB-like 2 AP1M1_MOUSE AP-1 complex subunit mu-1 AP1G1_MOUSE AP-1 complex subunit gamma-1 PAK3_MOUSE Serine/threonine-protein kinase PAK 3 CHRD1_MOUSE Cysteine and histidine-rich domain-containing protein 1 CSTF3_MOUSE Cleavage stimulation factor subunit 3 UB2G2_MOUSE Ubiquitin-conjugating enzyme E2 G2 RBBP4_MOUSE Histone-binding protein RBBP4 PACN2_MOUSE Protein kinase C and casein kinase substrate in neurons protein 2 CBX1_MOUSE Chromobox protein homolog 1 Q544X6_MOUSE Ferrochelatase WBP11_MOUSE WW domain-binding protein 11 MAP2_MOUSE Methionine aminopeptidase 2 CF211_MOUSE UPF0364 protein C6orf211 homolog PSPC1_MOUSE Paraspeckle component 1 RANB3_MOUSE Ran-binding protein 3 SCRN3_MOUSE Secernin-3 Q8K1M3_MOUSE Protein kinase, cAMP dependent regulatory, type II alpha Q78ZM0_MOUSE Sorting nexin 3 WDR61_MOUSE WD repeat-containing protein 61 VP26A_MOUSE Vacuolar protein sorting-associated protein 26A ZC11A_MOUSE Zinc finger CCCH domain-containing protein 11A UB2V1_MOUSE Ubiquitin-conjugating enzyme E2 variant 1 C43BP_MOUSE Collagen type IV alpha-3-binding protein CHCH6_MOUSE Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial HNRPF_MOUSE Heterogeneous nuclear ribonucleoprotein F CCS_MOUSE Copper chaperone for superoxide dismutase PRDBP_MOUSE Protein kinase C delta-binding protein RREB1_MOUSE Ras-responsive element-binding protein 1 G5E8R8_MOUSE MCG129950, isoform CRA_a ACYP1_MOUSE Acylphosphatase-1 LPIN1_MOUSE Phosphatidate phosphatase LPIN1 CIP4_MOUSE Isoform 3 of Cdc42-interacting protein 4 Q6ZWZ4_MOUSE 60S ribosomal protein L36 RPR1A_MOUSE Regulation of nuclear pre-mRNA domain-containing protein 1A HEXB_MOUSE Beta-hexosaminidase subunit beta DAG1_MOUSE Dystroglycan PSA3_MOUSE Proteasome subunit alpha type-3 PAXI_MOUSE Paxillin E9Q7L0_MOUSE Protein Ogdhl TPP1_MOUSE Tripeptidyl-peptidase 1
EP
Txnrd1 Dazap1 Nt5c3a Thumpd1 Dync1li2 Eif4e Vasp Agfg1 Dcp1a Ssrp1 Rpl31 Lpl Setd3 Acad8 Uba5 S100a13 Vat1 Wdr12 D2hgdh Tfb1m Flot1 Ruvbl2 Ap1m1 Ap1g1 Pak3 Chordc1 Cstf3 Ube2g2 Rbbp4 Pacsin2 Cbx1 Fech Wbp11 Metap2
AC C
sp|Q9JMH6|TRXR1_MOUSE sp|Q9JII5|DAZP1_MOUSE sp|Q9D020|5NT3A_MOUSE sp|Q99J36|THUM1_MOUSE sp|Q6PDL0|DC1L2_MOUSE sp|P63073|IF4E_MOUSE sp|P70460|VASP_MOUSE sp|Q8K2K6|AGFG1_MOUSE sp|Q91YD3|DCP1A_MOUSE sp|Q08943|SSRP1_MOUSE sp|P62900|RL31_MOUSE sp|P11152|LIPL_MOUSE sp|Q91WC0|SETD3_MOUSE sp|Q9D7B6|ACAD8_MOUSE sp|Q8VE47|UBA5_MOUSE sp|P97352|S10AD_MOUSE sp|Q62465|VAT1_MOUSE sp|Q9JJA4|WDR12_MOUSE sp|Q8CIM3|D2HDH_MOUSE sp|Q8JZM0|TFB1M_MOUSE sp|O08917|FLOT1_MOUSE sp|Q9WTM5|RUVB2_MOUSE sp|P35585|AP1M1_MOUSE sp|P22892|AP1G1_MOUSE sp|Q61036|PAK3_MOUSE sp|Q9D1P4|CHRD1_MOUSE sp|Q99LI7|CSTF3_MOUSE sp|P60605|UB2G2_MOUSE sp|Q60972|RBBP4_MOUSE sp|Q9WVE8|PACN2_MOUSE sp|P83917|CBX1_MOUSE tr|Q544X6|Q544X6_MOUSE sp|Q923D5|WBP11_MOUSE sp|O08663|MAP2_MOUSE sp|A6H630|CF211_MOUSE sp|Q8R326|PSPC1_MOUSE sp|Q9CT10|RANB3_MOUSE sp|Q3TMH2|SCRN3_MOUSE tr|Q8K1M3|Q8K1M3_MOUSE tr|Q78ZM0|Q78ZM0_MOUSE sp|Q9ERF3|WDR61_MOUSE sp|P40336|VP26A_MOUSE sp|Q6NZF1|ZC11A_MOUSE sp|Q9CZY3|UB2V1_MOUSE sp|Q9EQG9|C43BP_MOUSE sp|Q91VN4|CHCH6_MOUSE sp|Q9Z2X1|HNRPF_MOUSE sp|Q9WU84|CCS_MOUSE sp|Q91VJ2|PRDBP_MOUSE sp|Q3UH06|RREB1_MOUSE tr|G5E8R8|G5E8R8_MOUSE sp|P56376|ACYP1_MOUSE sp|Q91ZP3|LPIN1_MOUSE sp|Q8CJ53-3|CIP4_MOUSE tr|Q6ZWZ4|Q6ZWZ4_MOUSE sp|Q8VDS4|RPR1A_MOUSE sp|P20060|HEXB_MOUSE sp|Q62165|DAG1_MOUSE sp|O70435|PSA3_MOUSE sp|Q8VI36|PAXI_MOUSE tr|E9Q7L0|E9Q7L0_MOUSE sp|O89023|TPP1_MOUSE
296.341 276.145 304.973 435.79 547.862 426.952 332.427 284.596 338.507 658.614 359.966 460.902 313.197 337.231 397.841 455.209 412.546 310.226 203.89 411.826 283.24 384.725 518.653 236.843 552.71 349.118 371.661 247.981 373.814 265.343 315.712 381.217 385.531 269.886 487.507 432.863 372.629 427.005 262.11 452.998 265.745 352.459 303.298 444.298 366.044 303.686 248.409 381.155 487.523 250.57 387.345 425.72 227.522 414.46 255.925 398.395 627.998 390.644 490.736 413.367 273.501 345.406
621.143 628.806 505.616 575.557 470.68 542.925 572.903 293.685 366.884 271.498 290.227 386.503 211.513 292.005 384.296 365.18 582.83 390.192 202.195 208.672 361.108 473.297 423.078 595.24 507.65 603.949 394.589 223.101 314.947 469.98 216.5 247.492 256.12 327.725 537.084 551.583 551.817 628.84 314.163 354.241 296.874 302.915 412.989 368.763 333.975 422.136 588.583 602.576 418.821 263.179 393.373 342.699 114.877 713.359 286.949 388.373 545.709 349.366 541.839 525.725 393.754 224.762
504.346 1113.31 520.356 911.762 548.892 780.311 786.343 380.758 452.008 213.065 607.562 764.226 236.949 426.801 302.602 988.452 434.744 363.328 314.565 292.416 360.213 336.396 420.667 508.985 740.765 609.556 306.672 554.572 566.685 667.562 320.914 598.648 437.886 781.036 478.364 712.906 614.035 960.893 374.816 817.092 345.723 256.12 869.103 640.899 563.152 868.206 945.966 968.472 789.035 465.511 533.136 642.58 209.836 780.499 671.712 465.449 327.451 573.74 533.499 1045.59 396.283 387.168
1.01 1.01 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.95 0.94 0.94 0.94 0.94 0.93 0.93 0.93 0.93 0.92 0.91 0.90 0.90 0.90 0.90 0.90 0.88 0.87 0.87 0.87 0.86 0.86 0.86 0.86 0.84 0.84 0.84 0.82 0.82 0.81 0.74 0.72
1.93 3.01 1.60 1.45 0.93 1.31 1.96 1.12 1.10 0.38 1.19 1.42 0.66 1.11 0.90 1.36 1.06 0.98 1.14 0.57 1.17 0.95 0.93 2.41 0.94 1.51 0.87 1.44 1.05 1.93 0.70 0.88 0.79 1.84 0.86 1.38 1.35 1.61 1.11 1.09 1.10 0.78 1.89 1.02 1.09 1.73 2.45 1.71 0.89 1.16 0.92 0.91 0.57 1.35 1.77 0.86 0.65 0.89 0.90 1.41 0.93 0.59
ACCEPTED MANUSCRIPT
TE D
380.577 644.727 532.158 348.252 1243.08 253.137 220.279 274.048 255.956 316.023 361.058 294.672 262.308 317.312 224.385 260.636 200.694 223.211 193.222 221.112 282.693 198.094 180.889 281.233 185.601 343.622 274.499 380.661 264.514 254.169 393.603 234.551 418.369 292.209 363.427 295.988 468.564 204.87 294.925 360.735 478.244 533.273 432.381 250.93 238.582 167.143 186.311 225.895 410.608 273.825 293.815 365.688 413.332 434.654 375.339 259.545 261.512 282.813 233.472 521.345 286.679 262.359
318.843 469.846 246.772 479.746 1612.74 382.5 363.588 482.267 441.022 492.416 699.247 452.596 338.772 524.285 402.845 495.23 414.437 352.815 269.823 322.154 466.591 346.474 236.191 476.33 296.353 487.574 437.025 556.404 387.539 328.176 561.115 363.993 618.834 375.556 589.448 465.04 455.592 265.512 415.764 457.255 556.672 676.13 512.756 330.066 391.716 268.71 271.919 297.257 363.984 353.067 283.443 525.509 509.958 532.909 548.409 375.219 331.218 417.114 264.598 595.06 269.136 335.378
RI PT
482.931 700.728 306.942 319.571 799.791 218.552 234.241 272.049 284.263 340.206 474.189 320.316 255.783 359.27 267.089 329.171 312.671 276.739 205.544 257.095 342.836 243.093 221.224 357.256 234.124 357.862 337.677 382.337 330.458 252.434 462.108 306.137 456.353 309.764 416.95 382.238 438.008 208.636 322.961 402.206 430.47 568.458 490.323 280.892 365.892 246.229 233.385 233.591 254.284 318.98 293.967 440.206 455.918 422.757 442.704 327.193 319.728 365.365 221.995 506.958 285.815 292.103
SC
8 8 8 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
M AN U
GALM_MOUSE Aldose 1-epimerase ADRO_MOUSE NADPH:adrenodoxin oxidoreductase, mitochondrial FSCN1_MOUSE Fascin GNPAT_MOUSE Dihydroxyacetone phosphate acyltransferase BAP29_MOUSE B-cell receptor-associated protein 29 RDH13_MOUSE Retinol dehydrogenase 13 RT29_MOUSE 28S ribosomal protein S29, mitochondrial FA98A_MOUSE Protein FAM98A TMX2_MOUSE Thioredoxin-related transmembrane protein 2 RT25_MOUSE 28S ribosomal protein S25, mitochondrial XRCC6_MOUSE X-ray repair cross-complementing protein 6 CD47_MOUSE Leukocyte surface antigen CD47 CHM2A_MOUSE Charged multivesicular body protein 2a DHX29_MOUSE ATP-dependent RNA helicase Dhx29 ZW10_MOUSE Centromere/kinetochore protein zw10 homolog ADCK3_MOUSE Chaperone activity of bc1 complex-like, mitochondrial TOM40_MOUSE Mitochondrial import receptor subunit TOM40 homolog NOP58_MOUSE Nucleolar protein 58 FAK1_MOUSE Focal adhesion kinase 1 F7C846_MOUSE Metaxin-1 MTM1_MOUSE Myotubularin ERLN1_MOUSE Erlin-1 ADPGK_MOUSE ADP-dependent glucokinase MSH2_MOUSE DNA mismatch repair protein Msh2 APEX1_MOUSE DNA-(apurinic or apyrimidinic site) lyase KCC2G_MOUSE Isoform 3 of Calcium/calmodulin-dependent protein kinase type II subunit gamma RPB1_MOUSE DNA-directed RNA polymerase II subunit RPB1 K1468_MOUSE LisH domain and HEAT repeat-containing protein KIAA1468 NUDC1_MOUSE NudC domain-containing protein 1 MRCKB_MOUSE Serine/threonine-protein kinase MRCK beta KPBB_MOUSE Phosphorylase b kinase regulatory subunit beta MTCH2_MOUSE Mitochondrial carrier homolog 2 V9GX06_MOUSE Uncharacterized protein (Fragment) RS27_MOUSE 40S ribosomal protein S27 TMED4_MOUSE Transmembrane emp24 domain-containing protein 4 GT251_MOUSE Procollagen galactosyltransferase 1 FUND2_MOUSE FUN14 domain-containing protein 2 DEN4C_MOUSE DENN domain-containing protein 4C Q91Z50_MOUSE Flap endonuclease 1 B9EJ54_MOUSE MCG21756, isoform CRA_b LTN1_MOUSE E3 ubiquitin-protein ligase listerin TRI25_MOUSE E3 ubiquitin/ISG15 ligase TRIM25 PTCD3_MOUSE Pentatricopeptide repeat domain-containing protein 3, mitochondrial ITAV_MOUSE Integrin alpha-V RT09_MOUSE 28S ribosomal protein S9, mitochondrial DDX46_MOUSE Probable ATP-dependent RNA helicase DDX46 OCTC_MOUSE Peroxisomal carnitine O-octanoyltransferase UK114_MOUSE Ribonuclease UK114 H3C_MOUSE Histone H3.3C ACSF3_MOUSE Acyl-CoA synthetase family member 3, mitochondrial PLCB_MOUSE 1-acyl-sn-glycerol-3-phosphate acyltransferase beta FKB15_MOUSE FK506-binding protein 15 SERHL_MOUSE Serine hydrolase-like protein COG5_MOUSE Conserved oligomeric Golgi complex subunit 5 VAC14_MOUSE Protein VAC14 homolog PRP6_MOUSE Pre-mRNA-processing factor 6 TBL2_MOUSE Transducin beta-like protein 2 GUF1_MOUSE Translation factor Guf1, mitochondrial AP2M1_MOUSE AP-2 complex subunit mu DOC11_MOUSE Dedicator of cytokinesis protein 11 RL19_MOUSE 60S ribosomal protein L19 NHLC2_MOUSE NHL repeat-containing protein 2
EP
Galm Fdxr Fscn1 Gnpat Bcap29 Rdh13 Dap3 Fam98a Tmx2 Mrps25 Xrcc6 Cd47 Chmp2a Dhx29 Zw10 Adck3 Tomm40 Nop58 Ptk2 Mtx1 Mtm1 Erlin1 Adpgk Msh2 Apex1 Camk2g Polr2a Kiaa1468 Nudcd1 Cdc42bpb Phkb Mtch2 Gm11214 Rps27 Tmed4 Colgalt1 Fundc2 Dennd4c Fen1 Nup205 Ltn1 Trim25 Ptcd3 Itgav Mrps9 Ddx46 Crot Hrsp12 H3f3c Acsf3 Agpat2 Fkbp15 Serhl Cog5 Vac14 Prpf6 Tbl2 Guf1 Ap2m1 Dock11 Rpl19 Nhlrc2
AC C
sp|Q8K157|GALM_MOUSE sp|Q61578|ADRO_MOUSE sp|Q61553|FSCN1_MOUSE sp|P98192|GNPAT_MOUSE sp|Q61334|BAP29_MOUSE sp|Q8CEE7|RDH13_MOUSE sp|Q9ER88|RT29_MOUSE sp|Q3TJZ6|FA98A_MOUSE sp|Q9D710|TMX2_MOUSE sp|Q9D125|RT25_MOUSE sp|P23475|XRCC6_MOUSE sp|Q61735|CD47_MOUSE sp|Q9DB34|CHM2A_MOUSE sp|Q6PGC1|DHX29_MOUSE sp|O54692|ZW10_MOUSE sp|Q60936|ADCK3_MOUSE sp|Q9QYA2|TOM40_MOUSE sp|Q6DFW4|NOP58_MOUSE sp|P34152|FAK1_MOUSE tr|F7C846|F7C846_MOUSE sp|Q9Z2C5|MTM1_MOUSE sp|Q91X78|ERLN1_MOUSE sp|Q8VDL4|ADPGK_MOUSE sp|P43247|MSH2_MOUSE sp|P28352|APEX1_MOUSE sp|Q923T9-3|KCC2G_MOUSE sp|P08775|RPB1_MOUSE sp|Q148V7|K1468_MOUSE sp|Q6PIP5|NUDC1_MOUSE sp|Q7TT50|MRCKB_MOUSE sp|Q7TSH2|KPBB_MOUSE sp|Q791V5|MTCH2_MOUSE tr|V9GX06|V9GX06_MOUSE sp|Q6ZWU9|RS27_MOUSE sp|Q8R1V4|TMED4_MOUSE sp|Q8K297|GT251_MOUSE sp|Q9D6K8|FUND2_MOUSE sp|A6H8H2|DEN4C_MOUSE tr|Q91Z50|Q91Z50_MOUSE tr|B9EJ54|B9EJ54_MOUSE sp|Q6A009|LTN1_MOUSE sp|Q61510|TRI25_MOUSE sp|Q14C51|PTCD3_MOUSE sp|P43406|ITAV_MOUSE sp|Q9D7N3|RT09_MOUSE sp|Q569Z5|DDX46_MOUSE sp|Q9DC50|OCTC_MOUSE sp|P52760|UK114_MOUSE sp|P02301|H3C_MOUSE sp|Q3URE1|ACSF3_MOUSE sp|Q8K3K7|PLCB_MOUSE sp|Q6P9Q6|FKB15_MOUSE sp|Q9EPB5|SERHL_MOUSE sp|Q8C0L8|COG5_MOUSE sp|Q80WQ2|VAC14_MOUSE sp|Q91YR7|PRP6_MOUSE sp|Q9R099|TBL2_MOUSE sp|Q8C3X4|GUF1_MOUSE sp|P84091|AP2M1_MOUSE sp|A2AF47|DOC11_MOUSE sp|P84099|RL19_MOUSE sp|Q8BZW8|NHLC2_MOUSE
303.784 449.378 199.866 690.898 1809.88 331.563 316.481 326.174 345.712 447.087 495.997 405.245 379.046 412.29 273.822 300.63 260.941 304.205 251.188 300.195 342.117 222.677 281.52 344.105 235.078 399.306 335.7 400.093 350.567 298.306 493.506 301.95 437.139 350.225 343.681 342.978 623.089 224.488 314.565 444.496 517.263 625.349 570.696 294.3 315.157 213.908 217.351 237.81 404.55 331.373 393.511 402.046 488.056 449.684 383.4 292.479 329.122 314.353 245.968 555.911 370.953 284.495
367.785 608.869 675.274 470.411 1543.18 277.805 361.046 627.305 240.872 223.859 417.019 610.102 318.153 355.757 339.395 282.833 984.956 766.331 277.454 272.575 365.323 422.688 261.089 367.099 461.295 542.282 429.372 464.494 495.394 461.19 389.924 385.792 867.788 369.176 343.383 240.145 450.856 376.87 582.24 517.548 539.147 422.894 207.384 311.201 146.849 307.405 354.15 167.111 561.804 165.818 194.863 340.034 542.29 469.843 388.19 427.713 308.196 205.756 277.941 267.29 407.447 256.19
557.656 741.109 329.767 315.623 1106.57 268.951 593.96 481.146 172.394 297.099 466.089 342.201 234.467 313.624 309.561 579.399 290.828 366.386 385.342 154.655 222.592 175.132 182.752 282.919 230.975 735.38 331.016 498.288 319.431 338.929 418.422 230.669 662.159 265.232 262.774 200.657 454.242 353.862 528.375 314.528 575.052 543.008 351.521 230.289 234.175 284.121 170.572 307.644 354.047 249.436 230.466 437.324 559.908 305.302 385.611 275.326 237.867 236.763 230.912 324.818 644.266 240.697
0.72 0.68 0.53 1.75 1.68 1.51 1.50 1.48 1.46 1.43 1.43 1.39 1.39 1.38 1.38 1.35 1.32 1.31 1.31 1.30 1.29 1.29 1.29 1.28 1.27 1.26 1.26 1.25 1.24 1.24 1.23 1.23 1.21 1.21 1.20 1.19 1.19 1.18 1.18 1.18 1.18 1.18 1.17 1.17 1.17 1.17 1.17 1.16 1.16 1.15 1.15 1.15 1.15 1.15 1.14 1.14 1.14 1.13 1.12 1.12 1.12 1.12
1.07 1.00 1.20 1.18 1.30 1.16 2.10 2.03 0.76 0.79 1.06 1.55 1.07 0.99 1.32 1.46 2.49 2.27 1.66 0.89 0.94 1.36 1.10 1.02 1.65 1.82 1.24 1.26 1.37 1.58 0.94 1.14 1.75 1.05 0.78 0.65 1.00 1.77 1.80 1.09 1.23 0.88 0.61 1.02 0.63 1.43 1.25 1.03 1.38 0.70 0.72 0.96 1.27 0.90 0.95 1.20 0.94 0.68 1.12 0.58 1.84 0.90
ACCEPTED MANUSCRIPT
286.792 330.424 300.101 170.135 383.073 438.824 352.467 299.226 378.074 380.105 304.607 431.244 263.132 392.994 364.063 329.998 284.917 636.62 356.693 402.71 220.766 315.292 292.62 191.218 465.953 307.002 328.644 341.529 376.493 364.887 403.901 284.607 326.483 269.767 292.023 194.894 384.211 528.185 233.454 320.873 444.378 354.978 330.768 290.095 354.657 218.092 203.986 393.973 345.954 311.954 288.29 396.273 523.26 302.171 356.738 518.271 469.665 324.939 324.159 320.616 551.163 338.955
347.355 421.846 363.772 225.91 526.721 595.23 390.439 396.662 510.312 410.608 371.016 489.887 349.699 285.769 390.021 397.039 373.948 702.302 510.742 467.949 261.353 393.509 354.67 235.63 533.584 383.943 395.62 458.98 423.036 408.35 557.768 363.64 412.63 353.968 313.17 264.147 401.244 282.354 269.582 320.413 383.306 314.924 355.07 257.684 459.765 238.002 229.058 349.391 374.407 315.119 321.102 466.889 548.612 332.26 463.136 521.61 592.774 339.839 320.377 353.406 500.173 393.929
RI PT
258.841 359.179 322.783 179.291 451.234 520.253 311.936 349.499 459.673 368.435 323.148 379.111 294.443 286.97 342.378 351.328 332.578 722.25 445.026 451.54 235.919 362.81 303.836 236.231 483.002 365.995 393.974 446.715 381.765 336.976 485.372 346.423 369.517 362.502 301.94 238.513 343.467 266.09 281.536 324.494 331.928 283.211 320.378 262.683 486.829 217.479 221.982 311.973 358.49 323.222 266.763 509.381 496.797 356.674 440.932 457.147 636.681 337.782 288.77 313.677 572.527 378.602
SC
7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
M AN U
TE D
MIA40_MOUSE Mitochondrial intermembrane space import and assembly protein 40 NOP2_MOUSE Putative ribosomal RNA methyltransferase NOP2 MPP6_MOUSE MAGUK p55 subfamily member 6 PPM1B_MOUSE Protein phosphatase 1B GLCM_MOUSE Glucosylceramidase CRTAP_MOUSE Cartilage-associated protein PDCD5_MOUSE Programmed cell death protein 5 VPS25_MOUSE Vacuolar protein-sorting-associated protein 25 E9Q4K7_MOUSE Protein Kif13b NDUS5_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NCBP1_MOUSE Nuclear cap-binding protein subunit 1 UBQL2_MOUSE Ubiquilin-2 DYSF_MOUSE Dysferlin ARP10_MOUSE Actin-related protein 10 PNPO_MOUSE Pyridoxine-5'-phosphate oxidase KIF3B_MOUSE Kinesin-like protein KIF3B CELF2_MOUSE CUGBP Elav-like family member 2 RM03_MOUSE 39S ribosomal protein L3, mitochondrial ROCK1_MOUSE Rho-associated protein kinase 1 TPC11_MOUSE Trafficking protein particle complex subunit 11 ANKY2_MOUSE Ankyrin repeat and MYND domain-containing protein 2 SYCM_MOUSE Probable cysteine--tRNA ligase, mitochondrial SUMF2_MOUSE Sulfatase-modifying factor 2 RAB2A_MOUSE Ras-related protein Rab-2A EMC8_MOUSE ER membrane protein complex subunit 8 UMPS_MOUSE Uridine 5'-monophosphate synthase TIM50_MOUSE Mitochondrial import inner membrane translocase subunit TIM50 PARN_MOUSE Poly(A)-specific ribonuclease PARN ISCA1_MOUSE Iron-sulfur cluster assembly 1 homolog, mitochondrial RMP_MOUSE Unconventional prefoldin RPB5 interactor ACO13_MOUSE Acyl-coenzyme A thioesterase 13 D3Z0M9_MOUSE MCG18410, isoform CRA_a AP3S1_MOUSE AP-3 complex subunit sigma-1 GNPI2_MOUSE Glucosamine-6-phosphate isomerase 2 PEX14_MOUSE Peroxisomal membrane protein PEX14 PPR21_MOUSE Protein phosphatase 1 regulatory subunit 21 E9PX68_MOUSE Protein Slc4a1ap HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthase, cytoplasmic HDAC1_MOUSE Histone deacetylase 1 BROX_MOUSE BRO1 domain-containing protein BROX A1AG1_MOUSE Alpha-1-acid glycoprotein 1 CHM4B_MOUSE Charged multivesicular body protein 4b MD1L1_MOUSE Mitotic spindle assembly checkpoint protein MAD1 SMRC1_MOUSE SWI/SNF complex subunit SMARCC1 SIK2_MOUSE Serine/threonine-protein kinase SIK2 MIRO2_MOUSE Mitochondrial Rho GTPase 2 NIPA_MOUSE Nuclear-interacting partner of ALK PFD6_MOUSE Prefoldin subunit 6 PAPOA_MOUSE Poly(A) polymerase alpha CUL2_MOUSE Cullin-2 RABE1_MOUSE Rab GTPase-binding effector protein 1 RALY_MOUSE RNA-binding protein Raly SPF27_MOUSE Pre-mRNA-splicing factor SPF27 SAE1_MOUSE SUMO-activating enzyme subunit 1 NICA_MOUSE Nicastrin KLC1_MOUSE Kinesin light chain 1 SNR40_MOUSE U5 small nuclear ribonucleoprotein 40 kDa protein MYG1_MOUSE UPF0160 protein MYG1, mitochondrial SRRM1_MOUSE Serine/arginine repetitive matrix protein 1 F192A_MOUSE Protein FAM192A PDLI5_MOUSE PDZ and LIM domain protein 5 PRPF3_MOUSE U4/U6 small nuclear ribonucleoprotein Prp3
EP
Chchd4 Nop2 Mpp6 Ppm1b Gba Crtap Pdcd5 Vps25 Kif13b Ndufs5 Ncbp1 Ubqln2 Dysf Actr10 Pnpo Kif3b Celf2 Mrpl3 Rock1 Trappc11 Ankmy2 Cars2 Sumf2 Rab2a Emc8 Umps Timm50 Parn Isca1 Uri1 Acot13 Ddx23 Ap3s1 Gnpda2 Pex14 Ppp1r21 Slc4a1ap Hmgcs1 Hdac1 Brox Orm1 Chmp4b Mad1l1 Smarcc1 Sik2 Rhot2 Zc3hc1 Pfdn6 Papola Cul2 Rabep1 Raly Bcas2 Sae1 Ncstn Klc1 Snrnp40 Myg1 Srrm1 Fam192a Pdlim5 Prpf3
AC C
sp|Q8VEA4|MIA40_MOUSE sp|Q922K7|NOP2_MOUSE sp|Q9JLB0|MPP6_MOUSE sp|P36993|PPM1B_MOUSE sp|P17439|GLCM_MOUSE sp|Q9CYD3|CRTAP_MOUSE sp|P56812|PDCD5_MOUSE sp|Q9CQ80|VPS25_MOUSE tr|E9Q4K7|E9Q4K7_MOUSE sp|Q99LY9|NDUS5_MOUSE sp|Q3UYV9|NCBP1_MOUSE sp|Q9QZM0|UBQL2_MOUSE sp|Q9ESD7|DYSF_MOUSE sp|Q9QZB7|ARP10_MOUSE sp|Q91XF0|PNPO_MOUSE sp|Q61771|KIF3B_MOUSE sp|Q9Z0H4|CELF2_MOUSE sp|Q99N95|RM03_MOUSE sp|P70335|ROCK1_MOUSE sp|B2RXC1|TPC11_MOUSE sp|Q3TPE9|ANKY2_MOUSE sp|Q8BYM8|SYCM_MOUSE sp|Q8BPG6|SUMF2_MOUSE sp|P53994|RAB2A_MOUSE sp|O70378|EMC8_MOUSE sp|P13439|UMPS_MOUSE sp|Q9D880|TIM50_MOUSE sp|Q8VDG3|PARN_MOUSE sp|Q9D924|ISCA1_MOUSE sp|Q3TLD5|RMP_MOUSE sp|Q9CQR4|ACO13_MOUSE tr|D3Z0M9|D3Z0M9_MOUSE sp|Q9DCR2|AP3S1_MOUSE sp|Q9CRC9|GNPI2_MOUSE sp|Q9R0A0|PEX14_MOUSE sp|Q3TDD9|PPR21_MOUSE tr|E9PX68|E9PX68_MOUSE sp|Q8JZK9|HMCS1_MOUSE sp|O09106|HDAC1_MOUSE sp|Q8K2Q7|BROX_MOUSE sp|Q60590|A1AG1_MOUSE sp|Q9D8B3|CHM4B_MOUSE sp|Q9WTX8|MD1L1_MOUSE sp|P97496|SMRC1_MOUSE sp|Q8CFH6|SIK2_MOUSE sp|Q8JZN7|MIRO2_MOUSE sp|Q80YV2|NIPA_MOUSE sp|Q03958|PFD6_MOUSE sp|Q61183|PAPOA_MOUSE sp|Q9D4H8|CUL2_MOUSE sp|O35551|RABE1_MOUSE sp|Q64012|RALY_MOUSE sp|Q9D287|SPF27_MOUSE sp|Q9R1T2|SAE1_MOUSE sp|P57716|NICA_MOUSE sp|O88447|KLC1_MOUSE sp|Q6PE01|SNR40_MOUSE sp|Q9JK81|MYG1_MOUSE sp|Q52KI8|SRRM1_MOUSE sp|Q91WE2|F192A_MOUSE sp|Q8CI51|PDLI5_MOUSE sp|Q922U1|PRPF3_MOUSE
262.278 345.805 328.722 162.543 394.423 458.679 337.558 312.802 398.191 399.027 306.423 379.69 248.335 441.376 362.408 328.45 282.787 734.03 336.657 432.561 218.443 318.89 270.484 211.128 458.031 316.773 356.387 359.779 360.161 316.529 359.585 287.213 305.159 296.241 296.509 180.047 344.269 530.758 257.252 339.755 408.111 334.589 306.75 303.483 394.353 204.073 201.238 363.408 335.085 321.169 233.257 430.666 461.402 319.592 323.467 440.139 485.824 302.752 273.606 259.183 579.305 294.973
227.285 403.259 654.487 183.53 520.24 384.171 280.893 306.197 366.281 301.386 273.462 381.518 662.703 799.287 248.312 353.52 144.187 282.077 354.445 391.162 257.418 228.99 130.885 250.721 398.572 407.515 281.12 524.041 406.856 455.641 271.628 450.61 226.118 298.096 304.424 196.495 199.518 198.553 228.13 461.553 74.6766 269.561 467.3 573.685 158.061 248.853 278.346 321.928 287.057 416.512 349.668 127.762 461.134 470.508 302.77 476.053 593.298 176.89 254.33 143.121 563.594 361.396
533.133 306.948 702.514 321.018 386.588 282.401 560.937 293.202 391.893 604.08 315.869 1219 301.861 536.341 466.207 343.376 377.095 629.159 307.518 303.475 249.903 236.38 312.61 209.658 789.788 371.461 368.353 411.865 603.499 877.326 649.364 459.133 235.232 276.824 266.772 229.52 444.86 337.807 210.287 441.855 223.546 588.495 406.043 842.207 339.921 244.636 421.38 689.677 307.38 316.785 612.686 423.682 970.35 524.822 223.711 583.147 727.358 370.308 362.777 328.897 919.906 477.859
1.12 1.11 1.11 1.11 1.10 1.10 1.10 1.09 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.00 1.00 0.99 0.99 0.99 0.99 0.99 0.97 0.97 0.97 0.97 0.96 0.96
1.39 1.03 2.18 1.44 1.09 0.70 1.27 0.92 0.91 1.21 0.94 1.98 1.73 1.96 1.01 1.02 0.84 0.67 0.83 0.81 1.11 0.69 0.74 1.08 1.25 1.16 0.90 1.19 1.33 1.90 1.04 1.44 0.66 0.91 0.96 0.98 0.89 0.68 0.85 1.40 0.38 1.34 1.34 2.56 0.59 1.13 1.64 1.43 0.84 1.15 1.73 0.61 1.40 1.51 0.66 1.09 1.19 0.83 1.01 0.74 1.32 1.17
ACCEPTED MANUSCRIPT
561.669 335.547 369.486 536.275 247.566 390.203 249.793 281.82 312.003 351.909 559.58 457.915 517.567 390.475 227.74 331.135 440.378 391.98 329.021 542.403 242.943 274.411 516.874 194.013 377.698 350.919 287.338 318.455 358.429 258.365 434.01 493.534 248.479 488.15 580.938 285.975 358.151 248.782 353.569 387.845 503.72 271.447 389.276 586.74 290.647 404.85 437.016 294.727 341.339 372.721 427.716 340.887 365.499 412.162 392.216 423.446 330.027 291.713 221.743 3.26735 159.865 299.808
486.439 429.732 320.773 543.679 252.293 350.193 234.966 301.499 455.425 173.373 515.326 462.951 641.256 367.618 214.283 356.602 512.344 369.331 350.777 499.669 249.532 230.943 474.094 196.62 369.22 304.047 262.488 335.123 343.618 278.461 380.022 424.769 213.404 387.861 503.104 269.908 332.946 213.961 382.861 358.945 380.245 289.779 369.608 477.82 226.79 370.858 406.455 274.061 277.22 388.78 369.628 317.358 321.662 343.435 316.552 396.897 318.228 243.255 192.829 6.26539 351.607 542.304
RI PT
578.602 458.522 387.946 465.296 248.469 328.554 223.656 274.359 495.557 157.99 509.173 411.423 581.264 396.631 200.897 357.175 502.101 388.516 347.302 581.511 260.064 240.486 434.589 182.026 438.554 354.779 250.981 363.022 354.81 319.57 371.675 407.959 197.036 542.874 670.035 265.204 399.525 230.231 435.089 420.33 375.483 319.247 376.856 460.529 240.22 374.974 430.694 299.179 402.999 459.399 425.736 388.748 374.663 367.954 343.916 455.944 410.161 328.576 341.038 0.000366221 139.882 267.835
SC
7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 6 6 6
M AN U
TE D
RAB8A_MOUSE Ras-related protein Rab-8A LARP7_MOUSE La-related protein 7 NCKP1_MOUSE Nck-associated protein 1 CHSP1_MOUSE Calcium-regulated heat stable protein 1 COR1C_MOUSE Coronin-1C ZO1_MOUSE Tight junction protein ZO-1 PPIH_MOUSE Isoform 2 of Peptidyl-prolyl cis-trans isomerase H DEK_MOUSE Protein DEK MPI_MOUSE Mannose-6-phosphate isomerase SQSTM_MOUSE Sequestosome-1 NUDT5_MOUSE ADP-sugar pyrophosphatase COMD8_MOUSE COMM domain-containing protein 8 DIAP2_MOUSE Protein diaphanous homolog 2 TRM5_MOUSE tRNA (guanine(37)-N1)-methyltransferase STAM1_MOUSE Signal transducing adapter molecule 1 MSRA_MOUSE Mitochondrial peptide methionine sulfoxide reductase RBM5_MOUSE RNA-binding protein 5 YIF1A_MOUSE Protein YIF1A E9Q6J5_MOUSE Protein Bod1l UCKL1_MOUSE Uridine-cytidine kinase-like 1 ALKB5_MOUSE RNA demethylase ALKBH5 NEMO_MOUSE NF-kappa-B essential modulator ATOX1_MOUSE Copper transport protein ATOX1 MCTS1_MOUSE Malignant T-cell-amplified sequence 1 CDC16_MOUSE Cell division cycle protein 16 homolog MPP7_MOUSE MAGUK p55 subfamily member 7 SEP15_MOUSE 15 kDa selenoprotein CD11B_MOUSE Cyclin-dependent kinase 11B GID8_MOUSE Glucose-induced degradation protein 8 homolog CSK21_MOUSE Casein kinase II subunit alpha LEO1_MOUSE RNA polymerase-associated protein LEO1 TMF1_MOUSE TATA element modulatory factor CHIP_MOUSE STIP1 homology and U box-containing protein 1 PSB2_MOUSE Proteasome subunit beta type-2 ZADH2_MOUSE Zinc-binding alcohol dehydrogenase domain-containing protein 2 SRA1_MOUSE Steroid receptor RNA activator 1 OSBP1_MOUSE Oxysterol-binding protein 1 AFAP1_MOUSE Actin filament-associated protein 1 LMNB2_MOUSE Lamin-B2 NMI_MOUSE N-myc-interactor SRSF5_MOUSE Serine/arginine-rich splicing factor 5 UQCC2_MOUSE Ubiquinol-cytochrome-c reductase complex assembly factor 2 NUDT9_MOUSE ADP-ribose pyrophosphatase, mitochondrial RD23A_MOUSE UV excision repair protein RAD23 homolog A PAF1_MOUSE RNA polymerase II-associated factor 1 homolog T2FA_MOUSE General transcription factor IIF subunit 1 S10A1_MOUSE Protein S100-A1 SNX1_MOUSE Sorting nexin-1 G6PE_MOUSE GDH/6PGL endoplasmic bifunctional protein UAP1L_MOUSE UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 UFC1_MOUSE Ubiquitin-fold modifier-conjugating enzyme 1 PURA_MOUSE Transcriptional activator protein Pur-alpha FTO_MOUSE Alpha-ketoglutarate-dependent dioxygenase FTO NEB2_MOUSE Neurabin-2 LUC7L_MOUSE Putative RNA-binding protein Luc7-like 1 TXLNG_MOUSE Gamma-taxilin SRP09_MOUSE Signal recognition particle 9 kDa protein NIBAN_MOUSE Protein Niban AGAL_MOUSE Alpha-galactosidase A CNBP_MOUSE Cellular nucleic acid-binding protein SYUG_MOUSE Gamma-synuclein DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58
EP
Rab8a Larp7 Nckap1 Carhsp1 Coro1c Tjp1 Ppih Dek Mpi Sqstm1 Nudt5 Commd8 Diaph2 Trmt5 Stam Msra Rbm5 Yif1a Bod1l Uckl1 Alkbh5 Ikbkg Atox1 Mcts1 Cdc16 Mpp7 15-Sep Cdk11b Gid8 Csnk2a1 Leo1 Tmf1 Stub1 Psmb2 Zadh2 Sra1 Osbp Afap1 Lmnb2 Nmi Srsf5 Uqcc2 Nudt9 Rad23a Paf1 Gtf2f1 S100a1 Snx1 H6pd Uap1l1 Ufc1 Pura Fto Ppp1r9b Luc7l Txlng Srp9 Fam129a Gla Cnbp Sncg Ddx58
AC C
sp|P55258|RAB8A_MOUSE sp|Q05CL8|LARP7_MOUSE sp|P28660|NCKP1_MOUSE sp|Q9CR86|CHSP1_MOUSE sp|Q9WUM4|COR1C_MOUSE sp|P39447|ZO1_MOUSE sp|Q9D868-2|PPIH_MOUSE sp|Q7TNV0|DEK_MOUSE sp|Q924M7|MPI_MOUSE sp|Q64337|SQSTM_MOUSE sp|Q9JKX6|NUDT5_MOUSE sp|Q9CZG3|COMD8_MOUSE sp|O70566|DIAP2_MOUSE sp|Q9D0C4|TRM5_MOUSE sp|P70297|STAM1_MOUSE sp|Q9D6Y7|MSRA_MOUSE sp|Q91YE7|RBM5_MOUSE sp|Q91XB7|YIF1A_MOUSE tr|E9Q6J5|E9Q6J5_MOUSE sp|Q91YL3|UCKL1_MOUSE sp|Q3TSG4|ALKB5_MOUSE sp|O88522|NEMO_MOUSE sp|O08997|ATOX1_MOUSE sp|Q9DB27|MCTS1_MOUSE sp|Q8R349|CDC16_MOUSE sp|Q8BVD5|MPP7_MOUSE sp|Q9ERR7|SEP15_MOUSE sp|P24788|CD11B_MOUSE sp|Q9D7M1|GID8_MOUSE sp|Q60737|CSK21_MOUSE sp|Q5XJE5|LEO1_MOUSE sp|B9EKI3|TMF1_MOUSE sp|Q9WUD1|CHIP_MOUSE sp|Q9R1P3|PSB2_MOUSE sp|Q8BGC4|ZADH2_MOUSE sp|Q80VJ2|SRA1_MOUSE sp|Q3B7Z2|OSBP1_MOUSE sp|Q80YS6|AFAP1_MOUSE sp|P21619|LMNB2_MOUSE sp|O35309|NMI_MOUSE sp|O35326|SRSF5_MOUSE sp|Q9CQY6|UQCC2_MOUSE sp|Q8BVU5|NUDT9_MOUSE sp|P54726|RD23A_MOUSE sp|Q8K2T8|PAF1_MOUSE sp|Q3THK3|T2FA_MOUSE sp|P56565|S10A1_MOUSE sp|Q9WV80|SNX1_MOUSE sp|Q8CFX1|G6PE_MOUSE sp|Q3TW96|UAP1L_MOUSE sp|Q9CR09|UFC1_MOUSE sp|P42669|PURA_MOUSE sp|Q8BGW1|FTO_MOUSE sp|Q6R891|NEB2_MOUSE sp|Q9CYI4|LUC7L_MOUSE sp|Q8BHN1|TXLNG_MOUSE sp|P49962|SRP09_MOUSE sp|Q3UW53|NIBAN_MOUSE sp|P51569|AGAL_MOUSE sp|P53996|CNBP_MOUSE sp|Q9Z0F7|SYUG_MOUSE sp|Q6Q899|DDX58_MOUSE
605.325 330.511 404.114 412.421 220.894 335.283 215.692 226.933 311.831 309.572 496.393 356.103 392.104 372.509 188.574 290.094 370.612 361.62 282.61 547.375 216.427 244.44 398.917 147.319 376.001 338.66 225.207 281.483 300.293 240.147 341.273 382.229 184.541 531.111 610.759 220.612 339.897 211.151 310.712 350.421 390.818 227.878 299.825 437.209 233.812 304.951 336.319 233.806 357.886 320.434 353.716 294.124 298.202 308.016 274.061 307.5 241.967 188.48 176.717 4.14423 267.289 481.339
539.149 428.639 447.345 427.415 607.528 379.267 315.268 731.587 477.333 545.376 603.491 254.964 574.279 418.336 371.059 163.562 392.409 479.424 133.548 524.556 319.157 251.94 247.885 233.048 575.279 269.885 270.532 331.591 278.565 354.033 234.989 345.392 343.709 487.508 287.129 251.473 277.728 403.067 258.353 327.863 266.412 184.665 494.356 388.373 248.081 301.222 205.087 218.59 241.722 396.876 339.492 339.36 161.336 229.051 392.363 279.815 445.433 363.141 529.838 496.05 90.1862 486.852
570.048 580.217 378.893 1060.68 536.33 730.254 490.464 725.937 587.783 721.344 1269.34 591.115 399.222 594.509 462.474 360.183 722.646 576.562 333.992 386.513 375.865 497.714 968.111 277.918 503.606 421.429 481.128 320.015 640.904 258.003 639.707 778.52 642.818 384.96 304.887 596.561 344.647 538.426 382.484 676.618 725.638 315.03 1237.65 795.065 521.806 515.106 822.174 214.071 220.933 294.483 449.857 363.087 342.679 439.496 610.213 426.996 532.258 349.833 614.49 2093.64 106.382 339.395
0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.93 0.93 0.92 0.92 0.91 0.91 0.91 0.91 0.90 0.90 0.90 0.90 0.90 0.89 0.89 0.89 0.89 0.89 0.89 0.88 0.88 0.88 0.88 0.87 0.87 0.87 0.87 0.86 0.86 0.85 0.85 0.85 0.84 0.84 0.84 0.80 0.80 0.76 0.70 0.66 3.19 2.06 1.80
0.97 1.27 1.09 1.49 2.31 1.54 1.70 2.62 1.32 2.48 1.75 0.97 0.89 1.29 1.94 0.76 1.18 1.35 0.69 0.81 1.38 1.46 1.28 1.36 1.32 0.98 1.40 0.96 1.29 1.06 1.09 1.25 2.21 0.85 0.47 1.54 0.82 1.97 0.81 1.24 1.13 0.85 2.26 1.13 1.45 1.05 1.18 0.73 0.62 0.83 0.92 0.96 0.68 0.86 1.36 0.80 1.32 1.15 2.03 792.51 0.66 1.46
ACCEPTED MANUSCRIPT
107.147 227.918 293.724 324.055 245.223 285.077 302.876 347.056 491.608 317.22 213.364 264.333 209.206 367.145 283.11 183.321 187.753 489.529 228.716 245.309 148.088 232.202 166.294 241.803 218.74 326.262 261.377 270.524 255.062 194.447 317.328 270.902 168.184 309.233 302.599 259.874 281.053 319.652 284.796 253.567 205.223 346.496 456.069 212.752 356.565 183.643 275.409 321.795 228.893 228.457 276.399 195.514 210.249 272.262 610.352 390.756 186.117 294.509 170.322 286.561 255.712 159.785
142.544 242.786 482.432 388.932 409.033 436.471 484.528 549.836 807.112 526.097 298.962 533.941 306.345 571.322 542.465 317.197 288.371 614.972 446.372 399.731 255.595 269.258 197.338 280.679 350.784 444.002 271.346 345.158 327.367 281.813 448.308 459.28 301.222 429.767 360.262 358.439 474.866 440.364 448.006 320.254 306.289 559.317 597.319 321.095 495.132 217.065 389.879 410.1 272.92 234.676 317.065 292.051 268.925 375.377 738.898 518.83 266.27 396.304 172.57 375.394 331.606 244.014
RI PT
97.3294 153.035 329.616 313.585 242.624 271.392 309.59 341.693 429.876 386.147 231.164 326.416 205.932 398.896 342.939 208.536 205.261 389.717 316.734 281.482 193.515 184.476 138.466 193.05 250.275 294.512 215.872 269.959 252.12 215.361 317.154 311.033 227.895 320.906 294.467 266.991 344.583 349.994 337.065 273.264 231.886 470.969 420.775 258.892 390.494 147.836 338.663 268.681 257.257 232.57 251.738 235.842 224.932 310.973 548.656 407.666 219.256 308.204 118.356 289.638 256.361 199.288
SC
6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
M AN U
TE D
Fam210a Alcam Hsd17b7 Myo5a Ctnnd1 Ndufa7 Lpgat1 Srpr Eif2b2 Nbas Rps6ka3 Ndufb7 Rtn4 Casp3 Aak1 Dkc1 Swap70 Mrps30 Rai14 Nr3c1 Itga5 H2-K1 Exoc2 Oxa1l Adsl Nup155 Gapvd1 Rasa3 Tm9sf2 Fbl Rasa1 Adck1 Dock7 Tapt1 Atad1 Ralb Dtd1 Thumpd3 Mrps10 Mcat Skiv2l2 Ndufc2 Zyx Cpq Ubxn6 Nat10 Arsb Pgm3 Vars Arf4 Cyp20a1 B2m Trappc8 Fahd1 Elmo2 Pycr2 Rabgap1 Nek9 Usp25
C10_MOUSE Protein C10 UBC12_MOUSE NEDD8-conjugating enzyme Ubc12 ENV1_MOUSE MLV-related proviral Env polyprotein F210A_MOUSE Protein FAM210A CD166_MOUSE CD166 antigen DHB7_MOUSE 3-keto-steroid reductase MYO5A_MOUSE Unconventional myosin-Va CTND1_MOUSE Catenin delta-1 NDUA7_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 LGAT1_MOUSE Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 SRPR_MOUSE Signal recognition particle receptor subunit alpha EI2BB_MOUSE Translation initiation factor eIF-2B subunit beta E9Q411_MOUSE Protein Nbas KS6A3_MOUSE Ribosomal protein S6 kinase alpha-3 NDUB7_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 RTN4_MOUSE Reticulon-4 CASP3_MOUSE Caspase-3 AAK1_MOUSE AP2-associated protein kinase 1 DKC1_MOUSE H/ACA ribonucleoprotein complex subunit 4 SWP70_MOUSE Switch-associated protein 70 RT30_MOUSE 28S ribosomal protein S30, mitochondrial RAI14_MOUSE Ankycorbin GCR_MOUSE Glucocorticoid receptor ITA5_MOUSE Integrin alpha-5 HA1B_MOUSE H-2 class I histocompatibility antigen, K-B alpha chain EXOC2_MOUSE Exocyst complex component 2 OXA1L_MOUSE Mitochondrial inner membrane protein OXA1L PUR8_MOUSE Adenylosuccinate lyase NU155_MOUSE Nuclear pore complex protein Nup155 GAPD1_MOUSE GTPase-activating protein and VPS9 domain-containing protein 1 RASA3_MOUSE Ras GTPase-activating protein 3 TM9S2_MOUSE Transmembrane 9 superfamily member 2 FBRL_MOUSE rRNA 2'-O-methyltransferase fibrillarin E9PYG6_MOUSE Protein Rasa1 ADCK1_MOUSE Uncharacterized aarF domain-containing protein kinase 1 DOCK7_MOUSE Dedicator of cytokinesis protein 7 TAPT1_MOUSE Transmembrane anterior posterior transformation protein 1 ATAD1_MOUSE ATPase family AAA domain-containing protein 1 RALB_MOUSE Ras-related protein Ral-B DTD1_MOUSE D-tyrosyl-tRNA(Tyr) deacylase 1 THUM3_MOUSE THUMP domain-containing protein 3 RT10_MOUSE 28S ribosomal protein S10, mitochondrial FABD_MOUSE Malonyl-CoA-acyl carrier protein transacylase, mitochondrial SK2L2_MOUSE Superkiller viralicidic activity 2-like 2 NDUC2_MOUSE NADH dehydrogenase [ubiquinone] 1 subunit C2 ZYX_MOUSE Zyxin CBPQ_MOUSE Carboxypeptidase Q UBXN6_MOUSE UBX domain-containing protein 6 NAT10_MOUSE N-acetyltransferase 10 ARSB_MOUSE Arylsulfatase B AGM1_MOUSE Phosphoacetylglucosamine mutase SYVC_MOUSE Valine--tRNA ligase ARF4_MOUSE ADP-ribosylation factor 4 CP20A_MOUSE Cytochrome P450 20A1 B2MG_MOUSE Beta-2-microglobulin E9PWG2_MOUSE Protein Trappc8 FAHD1_MOUSE Acylpyruvase FAHD1, mitochondrial ELMO2_MOUSE Isoform 2 of Engulfment and cell motility protein 2 P5CR2_MOUSE Pyrroline-5-carboxylate reductase 2 RBGP1_MOUSE Rab GTPase-activating protein 1 NEK9_MOUSE Serine/threonine-protein kinase Nek9 UBP25_MOUSE Ubiquitin carboxyl-terminal hydrolase 25
EP
Grcc10 Ube2m
AC C
sp|O35127|C10_MOUSE sp|P61082|UBC12_MOUSE sp|P10404|ENV1_MOUSE sp|Q8BGY7|F210A_MOUSE sp|Q61490|CD166_MOUSE sp|O88736|DHB7_MOUSE sp|Q99104|MYO5A_MOUSE sp|P30999|CTND1_MOUSE sp|Q9Z1P6|NDUA7_MOUSE sp|Q91YX5|LGAT1_MOUSE sp|Q9DBG7|SRPR_MOUSE sp|Q99LD9|EI2BB_MOUSE tr|E9Q411|E9Q411_MOUSE sp|P18654|KS6A3_MOUSE sp|Q9CR61|NDUB7_MOUSE sp|Q99P72|RTN4_MOUSE sp|P70677|CASP3_MOUSE sp|Q3UHJ0|AAK1_MOUSE sp|Q9ESX5|DKC1_MOUSE sp|Q6A028|SWP70_MOUSE sp|Q9D0G0|RT30_MOUSE sp|Q9EP71|RAI14_MOUSE sp|P06537|GCR_MOUSE sp|P11688|ITA5_MOUSE sp|P01901|HA1B_MOUSE sp|Q9D4H1|EXOC2_MOUSE sp|Q8BGA9|OXA1L_MOUSE sp|P54822|PUR8_MOUSE sp|Q99P88|NU155_MOUSE sp|Q6PAR5|GAPD1_MOUSE sp|Q60790|RASA3_MOUSE sp|P58021|TM9S2_MOUSE sp|P35550|FBRL_MOUSE tr|E9PYG6|E9PYG6_MOUSE sp|Q9D0L4|ADCK1_MOUSE sp|Q8R1A4|DOCK7_MOUSE sp|Q4VBD2|TAPT1_MOUSE sp|Q9D5T0|ATAD1_MOUSE sp|Q9JIW9|RALB_MOUSE sp|Q9DD18|DTD1_MOUSE sp|P97770|THUM3_MOUSE sp|Q80ZK0|RT10_MOUSE sp|Q8R3F5|FABD_MOUSE sp|Q9CZU3|SK2L2_MOUSE sp|Q9CQ54|NDUC2_MOUSE sp|Q62523|ZYX_MOUSE sp|Q9WVJ3|CBPQ_MOUSE sp|Q99PL6|UBXN6_MOUSE sp|Q8K224|NAT10_MOUSE sp|P50429|ARSB_MOUSE sp|Q9CYR6|AGM1_MOUSE sp|Q9Z1Q9|SYVC_MOUSE sp|P61750|ARF4_MOUSE sp|Q8BKE6|CP20A_MOUSE sp|P01887|B2MG_MOUSE tr|E9PWG2|E9PWG2_MOUSE sp|Q8R0F8|FAHD1_MOUSE sp|Q8BHL5-2|ELMO2_MOUSE sp|Q922Q4|P5CR2_MOUSE sp|A2AWA9|RBGP1_MOUSE sp|Q8K1R7|NEK9_MOUSE sp|P57080|UBP25_MOUSE
203.485 396.882 426.179 540.316 301.259 369.617 402.606 442.511 516.161 456.386 319.655 277.209 263.423 477.301 313.442 210.414 239.323 563.117 272.142 293.529 193.817 274.696 200.184 285.717 258.907 356.104 338.544 344.174 318.098 238.189 356.694 278.524 200.467 359.583 386.706 299.014 304.628 393.037 321.299 327.158 228.086 437.328 471.228 253.423 412.405 184.04 350.726 300.753 311.835 316.59 312.801 222.343 249.835 318.72 639.971 430.939 215.633 319.755 169.592 303.595 271.151 177.329
238.556 858.935 401.04 372.528 327.487 392.24 693.922 406.477 494.822 448.926 291.952 236.884 346.257 550.18 444.157 258.633 359.915 275.616 334.559 239.648 115.463 352.21 213.019 345.419 115.735 463.266 195.373 731.409 526.45 564.431 203.208 353.749 289.328 372.533 248.606 390.036 377.036 360.273 314.277 196.52 284.738 166.698 470.414 356.867 454.142 276.288 296.596 282.219 275.149 209.389 314.534 372.534 361.434 292.598 240.26 506.082 237.365 313.573 408.719 349.933 210.25 167.093
432.8 1374.64 394.569 329.166 406.541 222.352 449.789 485.802 439.537 312.073 249.719 165.951 285.058 596.787 418.942 204.13 265.117 299.18 166.144 227.908 132.026 421.417 235.974 337.524 133.836 373.936 170.561 443.277 316.885 549.24 163.917 186.074 122.491 305.957 281.919 329.587 365.076 273.139 183.45 200.674 281.993 280.567 913.508 244.919 376.112 680.719 221.134 361.254 137.669 157.782 191.929 226.02 397.52 276.383 792.134 646.625 355.492 327.596 321.254 305.485 121.552 183.746
1.69 1.68 1.46 1.46 1.46 1.45 1.45 1.44 1.44 1.40 1.39 1.37 1.37 1.37 1.37 1.35 1.34 1.34 1.32 1.32 1.32 1.31 1.30 1.30 1.30 1.29 1.28 1.28 1.27 1.27 1.27 1.27 1.27 1.25 1.25 1.25 1.25 1.24 1.24 1.23 1.22 1.22 1.22 1.22 1.21 1.21 1.21 1.20 1.20 1.20 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.18 1.18 1.17
3.28 5.86 1.28 1.10 1.50 1.10 1.87 1.30 1.01 1.08 1.22 0.68 1.52 1.50 1.38 1.18 1.59 0.65 0.92 0.89 0.72 1.86 1.47 1.57 0.53 1.35 0.77 2.17 1.66 2.72 0.58 0.93 1.04 1.08 0.89 1.37 1.19 0.95 0.80 0.75 1.30 0.55 1.58 1.28 1.11 2.89 0.84 1.09 0.85 0.80 0.96 1.39 1.74 0.98 0.89 1.44 1.46 1.06 2.53 1.14 0.65 0.98
ACCEPTED MANUSCRIPT
Enah Prorsd1 U2af2 Trappc5 Usp39 Ganc Kank2 Mrpl51 Fam136a Vbp1 Aoc3 Lin7c
TE D
227.492 344.957 342.896 261.288 328.535 231.854 277.541 162.512 249.841 326.488 332.973 226.066 211.71 319.021 198.864 182.322 226.647 292.697 190.222 450.561 288.992 220.263 217.184 336.928 328.452 152.885 236.471 185.711 187.223 269.943 362.632 327.794 231.276 314.492 236.383 467.749 433.733 333.464 349.336 202.72 321.117 306.918 223.592 495.881 263.279 280.912 169.631 408.173 272.492 194.491 261.299 253.259 244.33 301.606 277.641 289.388 320.764 400.407 371.409 311.302 301.413 241.563
300.044 536.692 463.261 428.979 355.826 271.494 325.671 276.625 325.734 449.884 405.858 348.359 307.994 432.751 236.288 258.765 266.856 413.862 254.162 555.588 366.134 345.895 291.204 394.56 378.88 194.312 293.27 253.349 251.093 361.389 483.605 383.339 349.295 446.757 245.009 385.572 385.084 471.907 489.995 270.145 297.625 332.73 306.736 677.491 340.289 309.798 189.744 516.626 366.794 227.669 282.15 298.37 284.495 308.203 344.1 322.245 347.817 479.657 311.976 333.319 375.746 258.411
RI PT
239.7 364.509 364.048 371.206 316.573 210.605 229.31 233.487 245.55 347.301 337.6 308.109 197.792 355.518 218.581 205.594 246.43 290.756 206.651 526.233 271.088 292.38 262.922 322.31 295.12 162.757 270.78 221.077 220.225 317.006 435.759 349.526 315.394 371.649 240.797 428.241 318.017 395.773 418.458 226.933 241.64 293.77 283.499 613.809 305.318 252.292 167.943 469.322 344.456 186.86 232.233 247.061 253.299 290.505 303.904 326.075 338.221 409.456 275.464 289.29 373.793 227.464
SC
6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
M AN U
NAA35_MOUSE N-alpha-acetyltransferase 35, NatC auxiliary subunit PSME2_MOUSE Proteasome activator complex subunit 2 CDC73_MOUSE Parafibromin COQ6_MOUSE Ubiquinone biosynthesis monooxygenase COQ6 TBCD_MOUSE Tubulin-specific chaperone D GOGA1_MOUSE Golgin subfamily A member 1 UT14A_MOUSE U3 small nucleolar RNA-associated protein 14 homolog A ABCA1_MOUSE ATP-binding cassette sub-family A member 1 LONP2_MOUSE Lon protease homolog 2, peroxisomal AKAP9_MOUSE A-kinase anchor protein 9 DHAK_MOUSE Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) DAB2P_MOUSE Disabled homolog 2-interacting protein UFM1_MOUSE Ubiquitin-fold modifier 1 RO60_MOUSE 60 kDa SS-A/Ro ribonucleoprotein BAG6_MOUSE Large proline-rich protein BAG6 ERGI3_MOUSE Endoplasmic reticulum-Golgi intermediate compartment protein 3 STOM_MOUSE Erythrocyte band 7 integral membrane protein EHD3_MOUSE EH domain-containing protein 3 ERGI1_MOUSE Endoplasmic reticulum-Golgi intermediate compartment protein 1 ELMD2_MOUSE ELMO domain-containing protein 2 TATD1_MOUSE Putative deoxyribonuclease TATDN1 PTN23_MOUSE Tyrosine-protein phosphatase non-receptor type 23 PDIA5_MOUSE Protein disulfide-isomerase A5 CK5P3_MOUSE CDK5 regulatory subunit-associated protein 3 FKBP8_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP8 RASK_MOUSE GTPase KRas PGLT1_MOUSE Protein O-glucosyltransferase 1 VP33A_MOUSE Vacuolar protein sorting-associated protein 33A ARC1B_MOUSE Actin-related protein 2/3 complex subunit 1B LACB2_MOUSE Beta-lactamase-like protein 2 J3KMM1_MOUSE Ubiquitin carboxyl-terminal hydrolase ZN326_MOUSE DBIRD complex subunit ZNF326 DJC11_MOUSE DnaJ homolog subfamily C member 11 HSP13_MOUSE Heat shock 70 kDa protein 13 NU107_MOUSE Nuclear pore complex protein Nup107 CSN6_MOUSE COP9 signalosome complex subunit 6 MFAP1_MOUSE Microfibrillar-associated protein 1 VPS45_MOUSE Vacuolar protein sorting-associated protein 45 FMO1_MOUSE Dimethylaniline monooxygenase [N-oxide-forming] 1 STX12_MOUSE Syntaxin-12 LARP4_MOUSE La-related protein 4 PDIP3_MOUSE Polymerase delta-interacting protein 3 ABCF3_MOUSE ATP-binding cassette sub-family F member 3 EIF2A_MOUSE Eukaryotic translation initiation factor 2A GRDN_MOUSE Girdin HSBP1_MOUSE Heat shock factor-binding protein 1 COMT_MOUSE Catechol O-methyltransferase PNPH_MOUSE Purine nucleoside phosphorylase RHG17_MOUSE Rho GTPase-activating protein 17 CL065_MOUSE Probable peptide chain release factor C12orf65 homolog, mitochondrial ENAH_MOUSE Protein enabled homolog PRXD1_MOUSE Prolyl-tRNA synthetase associated domain-containing protein 1 U2AF2_MOUSE Splicing factor U2AF 65 kDa subunit TPPC5_MOUSE Trafficking protein particle complex subunit 5 SNUT2_MOUSE U4/U6.U5 tri-snRNP-associated protein 2 GANC_MOUSE Neutral alpha-glucosidase C KANK2_MOUSE KN motif and ankyrin repeat domain-containing protein 2 RM51_MOUSE 39S ribosomal protein L51, mitochondrial F136A_MOUSE Protein FAM136A PFD3_MOUSE Prefoldin subunit 3 AOC3_MOUSE Membrane primary amine oxidase LIN7C_MOUSE Protein lin-7 homolog C
EP
Naa35 Psme2 Cdc73 Coq6 Tbcd Golga1 Utp14a Abca1 Lonp2 Akap9 Dak Dab2ip Ufm1 Trove2 Bag6 Ergic3 Stom Ehd3 Ergic1 Elmod2 Tatdn1 Ptpn23 Pdia5 Cdk5rap3 Fkbp8 Kras Poglut1 Vps33a Arpc1b Lactb2 Usp19 Znf326 Dnajc11 Hspa13 Nup107 Cops6 Mfap1 Vps45 Fmo1 Stx12 Larp4 Poldip3 Abcf3 Eif2a Ccdc88a Hsbp1 Comt Pnp Arhgap17
AC C
sp|Q6PHQ8|NAA35_MOUSE sp|P97372|PSME2_MOUSE sp|Q8JZM7|CDC73_MOUSE sp|Q8R1S0|COQ6_MOUSE sp|Q8BYA0|TBCD_MOUSE sp|Q9CW79|GOGA1_MOUSE sp|Q640M1|UT14A_MOUSE sp|P41233|ABCA1_MOUSE sp|Q9DBN5|LONP2_MOUSE sp|Q70FJ1|AKAP9_MOUSE sp|Q8VC30|DHAK_MOUSE sp|Q3UHC7|DAB2P_MOUSE sp|P61961|UFM1_MOUSE sp|O08848|RO60_MOUSE sp|Q9Z1R2|BAG6_MOUSE sp|Q9CQE7|ERGI3_MOUSE sp|P54116|STOM_MOUSE sp|Q9QXY6|EHD3_MOUSE sp|Q9DC16|ERGI1_MOUSE sp|Q8BGF6|ELMD2_MOUSE sp|Q6P8M1|TATD1_MOUSE sp|Q6PB44|PTN23_MOUSE sp|Q921X9|PDIA5_MOUSE sp|Q99LM2|CK5P3_MOUSE sp|O35465|FKBP8_MOUSE sp|P32883|RASK_MOUSE sp|Q8BYB9|PGLT1_MOUSE sp|Q9D2N9|VP33A_MOUSE sp|Q9WV32|ARC1B_MOUSE sp|Q99KR3|LACB2_MOUSE tr|J3KMM1|J3KMM1_MOUSE sp|O88291|ZN326_MOUSE sp|Q5U458|DJC11_MOUSE sp|Q8BM72|HSP13_MOUSE sp|Q8BH74|NU107_MOUSE sp|O88545|CSN6_MOUSE sp|Q9CQU1|MFAP1_MOUSE sp|P97390|VPS45_MOUSE sp|P50285|FMO1_MOUSE sp|Q9ER00|STX12_MOUSE sp|Q8BWW4|LARP4_MOUSE sp|Q8BG81|PDIP3_MOUSE sp|Q8K268|ABCF3_MOUSE sp|Q8BJW6|EIF2A_MOUSE sp|Q5SNZ0|GRDN_MOUSE sp|Q9CQZ1|HSBP1_MOUSE sp|O88587|COMT_MOUSE sp|P23492|PNPH_MOUSE sp|Q3UIA2|RHG17_MOUSE sp|Q80VP5|CL065_MOUSE sp|Q03173|ENAH_MOUSE sp|Q9D820|PRXD1_MOUSE sp|P26369|U2AF2_MOUSE sp|Q9CQA1|TPPC5_MOUSE sp|Q3TIX9|SNUT2_MOUSE sp|Q8BVW0|GANC_MOUSE sp|Q8BX02|KANK2_MOUSE sp|Q9CPY1|RM51_MOUSE sp|Q9CR98|F136A_MOUSE sp|P61759|PFD3_MOUSE sp|O70423|AOC3_MOUSE sp|O88952|LIN7C_MOUSE
247.928 295.327 365.755 311.952 396.978 242.962 263.344 183.338 248.812 329.803 365.456 265.729 161.159 339.189 240.819 184.523 272.07 250.599 197.452 551.757 267.615 233.821 249.121 346.881 322.121 160.08 275.927 202.895 204.501 291.998 404.028 368.507 257.514 314.736 280.584 599.006 439.296 326.676 350.426 200.065 318.218 324.537 247.167 529.476 277.618 268.507 175.849 431.131 295.81 181.525 246.905 237.711 248.208 323.342 271.242 328.453 347.757 373.608 367.111 296.016 329.543 229.882
337.802 669.375 369.524 157.795 308.948 201.004 258.47 104.469 408.809 332.208 331.132 147.97 124.057 523.192 225.178 198.895 136.23 333.897 257.134 484.486 282.108 303.318 255.979 423.691 404.074 195.503 208.511 162.543 976.038 108.979 377.875 411.878 560.229 344.54 580.424 733.267 162.285 320.553 144.506 297.999 334.421 248.308 193.943 482.695 264.61 165.104 421.452 728.624 295.809 252.636 342.592 136.476 344.395 356.946 318.059 286.988 266.632 318.882 257.61 330.987 162.124 208.929
323.617 605.962 492.424 306.176 365.768 430.614 297.333 116.923 332.01 590.035 441.154 416.858 309.744 449.181 463.87 148.307 81.4129 463.298 173.779 434.831 500.337 341.134 197.956 422.498 373.581 227.66 197.215 169.364 672.995 223.286 741.083 1236.67 263.382 349.002 318.834 659.21 406.077 292.862 157.646 463.538 902.726 481.624 256.455 392.633 500.643 542.54 564.191 1153.9 227.434 336.952 692.997 213.063 542.284 297.563 216.514 232.585 371.442 482.302 699.462 561.598 177.861 408.619
1.17 1.17 1.17 1.17 1.17 1.16 1.16 1.16 1.16 1.16 1.15 1.15 1.15 1.14 1.14 1.14 1.14 1.14 1.14 1.13 1.13 1.13 1.13 1.12 1.12 1.12 1.12 1.12 1.12 1.11 1.11 1.11 1.11 1.11 1.10 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.05 1.05 1.05 1.04 1.04
1.42 1.80 1.22 0.73 1.05 1.43 1.10 0.56 1.50 1.37 1.15 1.06 1.06 1.44 1.65 0.90 0.46 1.37 1.09 0.94 1.40 1.26 0.95 1.28 1.25 1.34 0.80 0.82 4.05 0.57 1.40 2.43 1.51 1.01 1.88 1.55 0.76 0.84 0.39 1.77 2.20 1.22 0.89 0.79 1.35 1.33 2.92 2.15 0.85 1.55 2.10 0.70 1.78 1.11 0.92 0.84 0.97 0.99 1.48 1.49 0.50 1.32
ACCEPTED MANUSCRIPT
TE D
290.927 326.81 210.312 159.088 255.69 322.01 193.289 392.215 405.996 413.952 351.998 249.992 370.146 371.984 294.495 267.467 419.267 354.433 219.214 330.432 295.254 312.215 276.327 183.815 161.745 308.909 354.232 303.862 271.663 272.745 380.977 255.376 206.229 615.951 233.291 237.195 499.605 193.5 402.603 373.744 447.402 410.057 305.436 375.197 373.028 333.854 447.756 353.573 141.231 691.438 465.99 290.333 355.167 319.504 410.221 183.734 363.997 243.562 445.679 284.752 337.457 227.257
358.206 397.982 286.921 181.414 262.108 344.156 210.936 521.286 395.432 367.316 382.723 253.885 432.262 449.727 357.937 352.599 461.683 403.861 294.504 305.268 278.9 396.514 326.688 208.251 139.739 359.806 421.835 323.029 305.245 249.303 394.743 306.81 247.691 674.883 233.633 245.978 530.973 212.365 505.037 358.883 386.794 403.206 310.398 372.834 212.768 344.531 528.485 341.82 150.894 522.361 392.567 242.038 311.572 317.029 435.873 183.18 393.489 188.208 403.773 264.244 326.785 214.46
RI PT
342.092 374.247 281.281 177.269 242.641 327.242 189.285 477.948 374.121 333.595 339.4 266.092 381.019 426.704 367.662 334.444 454.429 392.919 313.077 259.527 301.708 415.874 338.515 201.942 129.686 424.436 440.036 287.166 292.595 261.731 371.108 337.015 244.043 669.277 230.916 202.312 480.215 211.236 570.475 338.208 454.52 371.46 340.854 327.404 178.763 402.777 578.857 324.671 149.073 595.985 338.22 295.035 267.862 306.965 433.834 182.74 383.591 259.571 443.866 327.036 309.758 209.09
SC
6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
M AN U
S2540_MOUSE Solute carrier family 25 member 40 CNNM2_MOUSE Metal transporter CNNM2 XPP3_MOUSE Probable Xaa-Pro aminopeptidase 3 FA49B_MOUSE Protein FAM49B RETN_MOUSE Resistin RPAP3_MOUSE RNA polymerase II-associated protein 3 MBNL2_MOUSE Muscleblind-like protein 2 SRPK2_MOUSE SRSF protein kinase 2 ARL1_MOUSE ADP-ribosylation factor-like protein 1 BRD2_MOUSE Bromodomain-containing protein 2 FRDA_MOUSE Frataxin, mitochondrial TM9S4_MOUSE Transmembrane 9 superfamily member 4 MMAB_MOUSE Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial KIF3A_MOUSE Kinesin-like protein KIF3A RHG05_MOUSE Rho GTPase-activating protein 5 BIEA_MOUSE Biliverdin reductase A KCC1A_MOUSE Calcium/calmodulin-dependent protein kinase type 1 EPN1_MOUSE Epsin-1 SF3B6_MOUSE Splicing factor 3B subunit 6 B1AWE0_MOUSE Clathrin light chain A RAB6A_MOUSE Ras-related protein Rab-6A SAFB2_MOUSE Scaffold attachment factor B2 MK09_MOUSE Mitogen-activated protein kinase 9 SART3_MOUSE Squamous cell carcinoma antigen recognized by T-cells 3 PGP_MOUSE Phosphoglycolate phosphatase PLOD3_MOUSE Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 ENOB_MOUSE Beta-enolase SH3G1_MOUSE Endophilin-A2 GLSK_MOUSE Glutaminase kidney isoform, mitochondrial SURF1_MOUSE Surfeit locus protein 1 ELOA1_MOUSE Transcription elongation factor B polypeptide 3 GSHB_MOUSE Glutathione synthetase RBBP6_MOUSE E3 ubiquitin-protein ligase RBBP6 VPS4B_MOUSE Vacuolar protein sorting-associated protein 4B OGT1_MOUSE UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OTU6B_MOUSE OTU domain-containing protein 6B SF3B5_MOUSE Splicing factor 3B subunit 5 CWC27_MOUSE Peptidyl-prolyl cis-trans isomerase CWC27 homolog FUCO_MOUSE Tissue alpha-L-fucosidase ZC21A_MOUSE Zinc finger C2HC domain-containing protein 1A TMED2_MOUSE Transmembrane emp24 domain-containing protein 2 ABI1_MOUSE Abl interactor 1 RABL6_MOUSE Rab-like protein 6 A16L1_MOUSE Autophagy-related protein 16-1 PLIN2_MOUSE Perilipin-2 ADPRH_MOUSE [Protein ADP-ribosylarginine] hydrolase PPA6_MOUSE Lysophosphatidic acid phosphatase type 6 UBAC1_MOUSE Ubiquitin-associated domain-containing protein 1 GALK1_MOUSE Galactokinase CATZ_MOUSE Cathepsin Z ESF1_MOUSE ESF1 homolog TXN4A_MOUSE Thioredoxin-like protein 4A NT5C_MOUSE 5'(3')-deoxyribonucleotidase, cytosolic type PEX5_MOUSE Isoform 2 of Peroxisomal targeting signal 1 receptor QORL1_MOUSE Quinone oxidoreductase-like protein 1 IF6_MOUSE Eukaryotic translation initiation factor 6 PPT1_MOUSE Palmitoyl-protein thioesterase 1 VP26B_MOUSE Vacuolar protein sorting-associated protein 26B HDGR2_MOUSE Hepatoma-derived growth factor-related protein 2 Q91X76_MOUSE 5'-nucleotidase domain containing 2 SMAP_MOUSE Small acidic protein 6PGL_MOUSE 6-phosphogluconolactonase
EP
Slc25a40 Cnnm2 Xpnpep3 Fam49b Retn Rpap3 Mbnl2 Srpk2 Arl1 Brd2 Fxn Tm9sf4 Mmab Kif3a Arhgap5 Blvra Camk1 Epn1 Sf3b6 Clta Rab6a Safb2 Mapk9 Sart3 Pgp Plod3 Eno3 Sh3gl1 Gls Surf1 Tceb3 Gss Rbbp6 Vps4b Ogt Otud6b Sf3b5 Cwc27 Fuca1 Zc2hc1a Tmed2 Abi1 Rabl6 Atg16l1 Plin2 Adprh Acp6 Ubac1 Galk1 Ctsz Esf1 Txnl4a Nt5c Pex5 Cryzl1 Eif6 Ppt1 Vps26b Hdgfrp2 Nt5dc2 Smap Pgls
AC C
sp|Q8BGP6|S2540_MOUSE sp|Q3TWN3|CNNM2_MOUSE sp|B7ZMP1|XPP3_MOUSE sp|Q921M7|FA49B_MOUSE sp|Q99P87|RETN_MOUSE sp|Q9D706|RPAP3_MOUSE sp|Q8C181|MBNL2_MOUSE sp|O54781|SRPK2_MOUSE sp|P61211|ARL1_MOUSE sp|Q7JJ13|BRD2_MOUSE sp|O35943|FRDA_MOUSE sp|Q8BH24|TM9S4_MOUSE sp|Q9D273|MMAB_MOUSE sp|P28741|KIF3A_MOUSE sp|P97393|RHG05_MOUSE sp|Q9CY64|BIEA_MOUSE sp|Q91YS8|KCC1A_MOUSE sp|Q80VP1|EPN1_MOUSE sp|P59708|SF3B6_MOUSE tr|B1AWE0|B1AWE0_MOUSE sp|P35279|RAB6A_MOUSE sp|Q80YR5|SAFB2_MOUSE sp|Q9WTU6|MK09_MOUSE sp|Q9JLI8|SART3_MOUSE sp|Q8CHP8|PGP_MOUSE sp|Q9R0E1|PLOD3_MOUSE sp|P21550|ENOB_MOUSE sp|Q62419|SH3G1_MOUSE sp|D3Z7P3|GLSK_MOUSE sp|P09925|SURF1_MOUSE sp|Q8CB77|ELOA1_MOUSE sp|P51855|GSHB_MOUSE sp|P97868|RBBP6_MOUSE sp|P46467|VPS4B_MOUSE sp|Q8CGY8|OGT1_MOUSE sp|Q8K2H2|OTU6B_MOUSE sp|Q923D4|SF3B5_MOUSE sp|Q3TKY6|CWC27_MOUSE sp|Q99LJ1|FUCO_MOUSE sp|Q8BJH1|ZC21A_MOUSE sp|Q9R0Q3|TMED2_MOUSE sp|Q8CBW3|ABI1_MOUSE sp|Q5U3K5|RABL6_MOUSE sp|Q8C0J2|A16L1_MOUSE sp|P43883|PLIN2_MOUSE sp|P54923|ADPRH_MOUSE sp|Q8BP40|PPA6_MOUSE sp|Q8VDI7|UBAC1_MOUSE sp|Q9R0N0|GALK1_MOUSE sp|Q9WUU7|CATZ_MOUSE sp|Q3V1V3|ESF1_MOUSE sp|P83877|TXN4A_MOUSE sp|Q9JM14|NT5C_MOUSE sp|O09012-2|PEX5_MOUSE sp|Q921W4|QORL1_MOUSE sp|O55135|IF6_MOUSE sp|O88531|PPT1_MOUSE sp|Q8C0E2|VP26B_MOUSE sp|Q3UMU9|HDGR2_MOUSE tr|Q91X76|Q91X76_MOUSE sp|Q9R0P4|SMAP_MOUSE sp|Q9CQ60|6PGL_MOUSE
300.235 328.309 221.476 164.638 249.678 320.536 179.893 365.016 399.135 393.35 320.243 270.305 327.446 356.973 310.235 254.764 419.643 349.948 241.846 287.803 320.194 331.618 286.104 175.838 150.355 367.163 363.151 260.997 251.648 277.372 343.813 273.735 193.535 579.466 219.293 182.338 423.851 181.09 438.952 331.621 486.228 351.09 311.406 302.335 310.809 351.951 441.338 298.337 123.025 686.619 362.393 305.955 270.503 267.291 350.853 157.841 302.014 279.772 421.897 298.946 267.047 184.822
372.155 272.939 160.644 354.37 50.7534 483.055 425.118 410.513 404.643 412.093 221.732 217.492 211.301 367.259 332.557 300.528 332.219 236.247 216.867 238.007 316.738 268.537 262.242 951.486 386.786 254.301 294.527 406.26 495.227 201.996 282.424 352.208 816.443 546.079 237.248 223.914 368.731 228.998 265.87 361.182 378.035 328.98 316.291 583.012 739.977 179.635 509.749 214.37 738.493 425.44 335.735 292.484 236.022 260.885 245.5 301.802 176.981 230.84 245.338 206.102 181.737 140.214
234.081 433.997 223.427 243.497 107.538 878.291 873.507 360.227 323.731 672.099 432.527 180.805 272.803 365.834 294.582 300.739 415.238 289.829 214.281 798.679 264.057 587.386 237.077 1081.51 681.765 192.639 378.842 683.965 464.444 239.551 569.185 540.287 2773.59 838.071 307.377 363.475 742.817 410.448 273.417 690.979 313.056 593.169 360.805 770.477 630.806 229.341 411.551 494.239 567.994 815.653 424.767 323.949 429.729 427.823 286.543 333.902 314.435 215.925 567.443 152.685 398.684 357.579
1.04 1.04 1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.00 1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.95 0.95 0.94 0.94 0.94 0.94 0.94 0.94 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.92 0.92 0.92
0.96 1.01 0.78 1.78 0.32 2.10 3.39 0.89 0.93 1.45 0.95 0.77 0.64 0.92 0.95 1.00 0.86 0.70 0.81 1.76 0.97 1.18 0.81 5.27 3.67 0.61 0.85 1.84 1.70 0.83 1.13 1.51 7.97 1.08 1.17 1.34 1.13 1.58 0.55 1.48 0.77 1.18 1.05 1.93 2.48 0.56 0.90 1.04 4.50 0.96 0.95 1.05 1.07 1.10 0.63 1.73 0.66 0.89 0.91 0.59 0.90 1.14
ACCEPTED MANUSCRIPT
347.373 199.448 496.216 460.357 310.381 365.662 209.167 354.568 585.252 267.495 254.101 333.52 303.538 254.305 400.304 422.43 264.868 393.609 299.359 244.797 456.849 308.695 200.776 216.752 153.956 419.336 544.38 248.126 375.87 329.295 473.757 281.487 211.063 342.016 218.499 357.996 340.804 325.816 376.289 241.926 287.404 487.859 164.363 344.837 532.035 120.463 233.474 138.256 267.026 393.999 254.357 185.794 157.116 121.677 155.214 161.278 269.996 214.57 207.455 318.722 163.198 270.361
364.753 211.526 399.769 495.274 292.961 295.692 219.383 310.581 416.066 240.169 220.013 364.989 287.91 282.739 415.44 400.94 236.127 397.487 277.666 212.933 493.235 281.989 168.99 193.913 136.369 172.493 448.469 254.827 345.367 294.926 437.349 218.544 179.084 295.815 216.202 415.497 248.596 252.611 340.235 203.544 169.828 412.265 147.512 246.197 424.681 400.782 538.396 290.069 785.415 684.821 392.556 339.906 274.194 277.777 272.304 371.447 462.099 450.889 344.304 567.576 281.984 454.786
RI PT
382.584 206.393 452.52 532.232 292.526 289.605 223.146 331.978 441.746 247.552 225.278 401.158 325.56 280.986 478.083 407.719 287.02 442.306 359.279 234.489 532.319 269.866 190.675 233.98 147.949 195.515 449.781 309.845 370.55 313.973 437.717 243.33 187.692 402.399 256.164 521.932 434.714 297.843 455.738 271.584 264.602 646.202 228.244 345.808 541.896 125.867 353.635 157.659 349.126 366.597 221.504 172.151 155.188 179.615 149.436 212.931 216.806 265.64 248.571 324.984 168.228 281.668
SC
6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
M AN U
TE D
Col4a2 Nelfe Bin1 Cpped1 Rnf40 Eif3k Nagk Rnps1 Plbd2 Rbm12 Prmt5 Brd4 Fcho2 Palm2 Cope Uprt Rbbp9 Pank3 Smndc1 Tsnax Brd3 Ccdc58 Bag4 Ube2a Ubxn1 Qsox2 Hdhd2 Vps29 Usp4 Srp19 Sardh Pcmt1 Tceb1 Spryd4 Dpp7 Gamt Snrnp27 Cnn2 Clca1 Gbp2 Ndufa9 Cidec Eefsec Itpr1 S100a4 Serpinb1a Trmu Gypc Mrpl11 Slc1a3 B3galtl Mp68 Nqo1 Mcm6
UBC9_MOUSE SUMO-conjugating enzyme UBC9 ZN207_MOUSE BUB3-interacting and GLEBS motif-containing protein ZNF207 RAE1L_MOUSE mRNA export factor MPPB_MOUSE Mitochondrial-processing peptidase subunit beta LRC47_MOUSE Leucine-rich repeat-containing protein 47 TCEA1_MOUSE Transcription elongation factor A protein 1 PITM1_MOUSE Membrane-associated phosphatidylinositol transfer protein 1 CG050_MOUSE Uncharacterized protein C7orf50 homolog CO4A2_MOUSE Collagen alpha-2(IV) chain NELFE_MOUSE Negative elongation factor E BIN1_MOUSE Myc box-dependent-interacting protein 1 CPPED_MOUSE Calcineurin-like phosphoesterase domain-containing protein 1 BRE1B_MOUSE E3 ubiquitin-protein ligase BRE1B EIF3K_MOUSE Eukaryotic translation initiation factor 3 subunit K NAGK_MOUSE N-acetyl-D-glucosamine kinase RNPS1_MOUSE RNA-binding protein with serine-rich domain 1 PLBL2_MOUSE Putative phospholipase B-like 2 RBM12_MOUSE RNA-binding protein 12 ANM5_MOUSE Protein arginine N-methyltransferase 5 BRD4_MOUSE Bromodomain-containing protein 4 FCHO2_MOUSE FCH domain only protein 2 PALM2_MOUSE Paralemmin-2 COPE_MOUSE Coatomer subunit epsilon UPP_MOUSE Uracil phosphoribosyltransferase homolog RBBP9_MOUSE Putative hydrolase RBBP9 PANK3_MOUSE Pantothenate kinase 3 SPF30_MOUSE Survival of motor neuron-related-splicing factor 30 TSNAX_MOUSE Translin-associated protein X BRD3_MOUSE Bromodomain-containing protein 3 CCD58_MOUSE Coiled-coil domain-containing protein 58 BAG4_MOUSE BAG family molecular chaperone regulator 4 UBE2A_MOUSE Ubiquitin-conjugating enzyme E2 A UBXN1_MOUSE UBX domain-containing protein 1 QSOX2_MOUSE Sulfhydryl oxidase 2 HDHD2_MOUSE Haloacid dehalogenase-like hydrolase domain-containing protein 2 VPS29_MOUSE Vacuolar protein sorting-associated protein 29 UBP4_MOUSE Ubiquitin carboxyl-terminal hydrolase 4 SRP19_MOUSE Signal recognition particle 19 kDa protein SARDH_MOUSE Sarcosine dehydrogenase, mitochondrial PIMT_MOUSE Protein-L-isoaspartate(D-aspartate) O-methyltransferase ELOC_MOUSE Transcription elongation factor B polypeptide 1 SPRY4_MOUSE SPRY domain-containing protein 4 DPP2_MOUSE Dipeptidyl peptidase 2 GAMT_MOUSE Guanidinoacetate N-methyltransferase SNR27_MOUSE U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein CNN2_MOUSE Calponin-2 Q9QX15_MOUSE Calcium-activated chloride channel regulator 1 GBP2_MOUSE Interferon-induced guanylate-binding protein 2 NDUA9_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial CIDEC_MOUSE Cell death activator CIDE-3 SELB_MOUSE Selenocysteine-specific elongation factor ITPR1_MOUSE Inositol 1,4,5-trisphosphate receptor type 1 S10A4_MOUSE Protein S100-A4 ILEUA_MOUSE Leukocyte elastase inhibitor A MTU1_MOUSE Mitochondrial tRNA-specific 2-thiouridylase 1 GLPC_MOUSE Glycophorin-C RM11_MOUSE 39S ribosomal protein L11, mitochondrial EAA1_MOUSE Excitatory amino acid transporter 1 B3GLT_MOUSE Beta-1,3-glucosyltransferase 68MP_MOUSE 6.8 kDa mitochondrial proteolipid NQO1_MOUSE NAD(P)H dehydrogenase [quinone] 1 MCM6_MOUSE DNA replication licensing factor MCM6
EP
Ube2i Znf207 Rae1 Pmpcb Lrrc47 Tcea1 Pitpnm1
AC C
sp|P63280|UBC9_MOUSE sp|Q9JMD0|ZN207_MOUSE sp|Q8C570|RAE1L_MOUSE sp|Q9CXT8|MPPB_MOUSE sp|Q505F5|LRC47_MOUSE sp|P10711|TCEA1_MOUSE sp|O35954|PITM1_MOUSE sp|Q9CXL3|CG050_MOUSE sp|P08122|CO4A2_MOUSE sp|P19426|NELFE_MOUSE sp|O08539|BIN1_MOUSE sp|Q8BFS6|CPPED_MOUSE sp|Q3U319|BRE1B_MOUSE sp|Q9DBZ5|EIF3K_MOUSE sp|Q9QZ08|NAGK_MOUSE sp|Q99M28|RNPS1_MOUSE sp|Q3TCN2|PLBL2_MOUSE sp|Q8R4X3|RBM12_MOUSE sp|Q8CIG8|ANM5_MOUSE sp|Q9ESU6|BRD4_MOUSE sp|Q3UQN2|FCHO2_MOUSE sp|Q8BR92|PALM2_MOUSE sp|O89079|COPE_MOUSE sp|B1AVZ0|UPP_MOUSE sp|O88851|RBBP9_MOUSE sp|Q8R2W9|PANK3_MOUSE sp|Q8BGT7|SPF30_MOUSE sp|Q9QZE7|TSNAX_MOUSE sp|Q8K2F0|BRD3_MOUSE sp|Q8R3Q6|CCD58_MOUSE sp|Q8CI61|BAG4_MOUSE sp|Q9Z255|UBE2A_MOUSE sp|Q922Y1|UBXN1_MOUSE sp|Q3TMX7|QSOX2_MOUSE sp|Q3UGR5|HDHD2_MOUSE sp|Q9QZ88|VPS29_MOUSE sp|P35123|UBP4_MOUSE sp|Q9D7A6|SRP19_MOUSE sp|Q99LB7|SARDH_MOUSE sp|P23506|PIMT_MOUSE sp|P83940|ELOC_MOUSE sp|Q91WK1|SPRY4_MOUSE sp|Q9ET22|DPP2_MOUSE sp|O35969|GAMT_MOUSE sp|Q8K194|SNR27_MOUSE sp|Q08093|CNN2_MOUSE tr|Q9QX15|Q9QX15_MOUSE sp|Q9Z0E6|GBP2_MOUSE sp|Q9DC69|NDUA9_MOUSE sp|P56198|CIDEC_MOUSE sp|Q9JHW4|SELB_MOUSE sp|P11881|ITPR1_MOUSE sp|P07091|S10A4_MOUSE sp|Q9D154|ILEUA_MOUSE sp|Q9DAT5|MTU1_MOUSE sp|Q78HU7|GLPC_MOUSE sp|Q9CQF0|RM11_MOUSE sp|P56564|EAA1_MOUSE sp|Q8BHT6|B3GLT_MOUSE sp|P56379|68MP_MOUSE sp|Q64669|NQO1_MOUSE sp|P97311|MCM6_MOUSE
301.525 158.701 464.15 407.291 255.074 299.895 172.177 310.829 509.988 222.234 210.361 293.393 275.283 195.584 367.561 338.403 254.253 341.328 303.614 209.077 377.182 225.094 172.232 198.615 126.148 358.609 398.964 220.307 289.728 250.717 331.157 219.139 152.834 320.644 176.467 310.318 360.219 235.975 307.221 191.321 239.458 428.06 127.2 220.206 252.941 327.376 558.548 235.927 286.47 622.328 415.14 263.64 241.269 217.835 219.444 226.71 296.573 278.049 345.882 396.804 213.994 368.907
474.71 131.268 462.582 210.861 394.715 358.475 212.674 244.716 123.172 182.527 216.088 172.539 177.823 253.879 401.822 239.055 184.319 351.704 370.891 205.156 441.164 127.958 266.745 198.571 621.312 488.719 229.923 245.189 334.453 252.154 249.033 229.126 190.919 351.327 145.55 760.31 385.805 446.079 318.94 189.416 317.611 216.278 95.5498 91.6659 330.997 151.627 121.521 118.956 430.439 115.89 418.787 519.473 205.8 139.029 138.823 134.849 132.019 136.331 233.392 352.095 367.833 378.901
810.073 250.678 748.195 952.75 590.888 575.109 193.975 321.793 178.998 356.81 415.943 187.857 303.682 398.552 358.075 612.335 136.529 723.674 285.687 298.028 644.049 349.039 305.292 211.985 928.915 714.347 570.713 274.173 651.426 416.947 773.107 630.173 408.266 314.921 222.129 643.245 446.719 762.041 334.29 312.312 532.556 410.755 85.4563 248.774 577.983 138.117 157.948 112.286 258.532 351.975 259.628 408.099 387.31 164.06 221.469 139.666 286.666 111.509 145.219 129.964 417.816 252.145
0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.90 0.90 0.90 0.90 0.90 0.89 0.89 0.89 0.89 0.88 0.88 0.88 0.88 0.88 0.87 0.87 0.87 0.86 0.85 0.85 0.85 0.85 0.84 0.83 0.83 0.83 0.83 0.82 0.79 0.78 0.78 0.77 0.74 0.74 0.70 0.68 0.63 2.96 1.87 1.78 1.74 1.72 1.70 1.69 1.65 1.64 1.61 1.60 1.56 1.52 1.51 1.50 1.50 1.49
1.76 0.94 1.28 1.17 1.63 1.42 0.94 0.83 0.29 1.05 1.32 0.49 0.77 1.22 0.87 1.03 0.58 1.29 1.00 1.05 1.10 0.82 1.46 0.91 5.13 1.96 0.81 0.93 1.32 1.04 1.12 1.64 1.50 0.89 0.77 1.60 1.07 1.94 0.79 0.98 1.54 0.55 0.46 0.49 0.85 1.18 0.48 0.78 1.12 0.62 1.43 2.59 1.90 1.01 1.18 0.73 0.86 0.52 0.83 0.75 2.37 1.14
ACCEPTED MANUSCRIPT
215.471 179.189 239.846 158.319 163.584 336.646 183.47 171.994 160.468 311.074 195.784 198.612 171.835 125.332 237.27 345.184 105.416 209.918 156.449 194.595 184.94 250.148 147.198 255.868 177.604 99.9995 189.235 375.55 170.591 166.031 198.815 228.906 374.151 135.656 216.176 235.922 101.417 265.891 275.992 224.191 180.801 226.262 190.602 167.493 113.727 241.655 185.113 212.11 272.844 150.835 298.206 393.876 249.268 238.692 169.547 361.167 218.562 209.796 302.82 262.665 222.062 514.402
191.456 351.742 451.175 254.11 326.045 403.918 284.609 212.252 292.798 441.515 224.79 368.3 308.763 179.207 307.772 458.342 171.147 304.61 243.043 387.57 291.98 242.478 231.807 423.547 186.479 166.482 230.542 717.002 239.062 196.713 205.197 346.636 245.163 207.898 321.17 276.077 149.334 367.373 348.904 285.495 272.489 290.552 253.176 273.473 131.36 357.203 258.549 320.688 340.997 211.139 442.555 506.534 263.218 326.789 262.97 507.73 268.606 254.247 433.863 342.937 252.316 554.85
RI PT
150.703 181.804 284.149 168.889 219.262 239.315 196.074 139.5 195.893 272.512 155.912 249.012 205.839 122.914 210.931 322.578 138.239 206 176.586 291.247 217.846 188.444 157.417 313.864 150.543 136.617 173.11 511.682 180.764 139.504 150.788 260.466 223.019 157.68 249.186 204.373 116.664 271.478 268.125 215.581 200.766 213.439 189.139 217.291 105.124 321.821 198.316 261.657 257.414 169.938 366.18 367.798 209.67 267.749 217.775 390.811 243.771 206.888 325.953 284.96 195.498 429.568
SC
5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
M AN U
TE D
Sparcl1 Supt16h Sbsn Mrpl28 Nop14 Xpot Adam9 Slc38a10 Pdcd11 Usp8 Ppp1r10 Abcb6 Clasp1 Dnajc1 Mrps15 Emc4 Psmb5 Ociad1 Lnp Raf1 Rxra Ttc37 Slc2a4 Ap3m1 Maged1 Tnpo3 Mrps7 Rpl36a Ccdc132 Sort1 Unc45a Pcbp2 Tmx4 Thoc5 Yars2 Ints3 Cnot10 Ddx52 Ppfia1 Lsm14a Mpdu1 Eif2b4 Aldh5a1 Nek7 Stk3 Tsn Mrpl50 Srsf1 Arl2 Elac2 Gna13 Myo1b Thoc2 Cpne1 Myo18a Vps39 Eif4ebp1
ERH_MOUSE Enhancer of rudimentary homolog EXOC1_MOUSE Exocyst complex component 1 RM37_MOUSE 39S ribosomal protein L37, mitochondrial SIN3A_MOUSE Paired amphipathic helix protein Sin3a CN159_MOUSE UPF0317 protein C14orf159 homolog, mitochondrial SPRL1_MOUSE SPARC-like protein 1 SP16H_MOUSE FACT complex subunit SPT16 SBSN_MOUSE Suprabasin RM28_MOUSE 39S ribosomal protein L28, mitochondrial NOP14_MOUSE Nucleolar protein 14 XPOT_MOUSE Exportin-T ADAM9_MOUSE Disintegrin and metalloproteinase domain-containing protein 9 S38AA_MOUSE Putative sodium-coupled neutral amino acid transporter 10 RRP5_MOUSE Protein RRP5 homolog UBP8_MOUSE Ubiquitin carboxyl-terminal hydrolase 8 PP1RA_MOUSE Serine/threonine-protein phosphatase 1 regulatory subunit 10 ABCB6_MOUSE ATP-binding cassette sub-family B member 6, mitochondrial CLAP1_MOUSE CLIP-associating protein 1 DNJC1_MOUSE DnaJ homolog subfamily C member 1 RT15_MOUSE 28S ribosomal protein S15, mitochondrial EMC4_MOUSE ER membrane protein complex subunit 4 PSB5_MOUSE Proteasome subunit beta type-5 OCAD1_MOUSE OCIA domain-containing protein 1 LNP_MOUSE Protein lunapark RAF1_MOUSE RAF proto-oncogene serine/threonine-protein kinase RXRA_MOUSE Retinoic acid receptor RXR-alpha F8VPK0_MOUSE Protein Ttc37 GTR4_MOUSE Solute carrier family 2, facilitated glucose transporter member 4 AP3M1_MOUSE AP-3 complex subunit mu-1 MAGD1_MOUSE Melanoma-associated antigen D1 TNPO3_MOUSE Transportin-3 RT07_MOUSE 28S ribosomal protein S7, mitochondrial RL36A_MOUSE 60S ribosomal protein L36a CC132_MOUSE Coiled-coil domain-containing protein 132 SORT_MOUSE Sortilin UN45A_MOUSE Protein unc-45 homolog A PCBP2_MOUSE Poly(rC)-binding protein 2 TMX4_MOUSE Thioredoxin-related transmembrane protein 4 THOC5_MOUSE THO complex subunit 5 homolog SYYM_MOUSE Tyrosine--tRNA ligase, mitochondrial INT3_MOUSE Integrator complex subunit 3 CNO10_MOUSE CCR4-NOT transcription complex subunit 10 DDX52_MOUSE Probable ATP-dependent RNA helicase DDX52 B2RXQ2_MOUSE Ppfia1 protein LS14A_MOUSE Protein LSM14 homolog A MPU1_MOUSE Mannose-P-dolichol utilization defect 1 protein EI2BD_MOUSE Translation initiation factor eIF-2B subunit delta SSDH_MOUSE Succinate-semialdehyde dehydrogenase, mitochondrial NEK7_MOUSE Serine/threonine-protein kinase Nek7 STK3_MOUSE Serine/threonine-protein kinase 3 TSN_MOUSE Translin RM50_MOUSE 39S ribosomal protein L50, mitochondrial SRSF1_MOUSE Serine/arginine-rich splicing factor 1 ARL2_MOUSE ADP-ribosylation factor-like protein 2 RNZ2_MOUSE Zinc phosphodiesterase ELAC protein 2 GNA13_MOUSE Guanine nucleotide-binding protein subunit alpha-13 MYO1B_MOUSE Unconventional myosin-Ib THOC2_MOUSE THO complex subunit 2 CPNE1_MOUSE Copine-1 MY18A_MOUSE Unconventional myosin-XVIIIa VPS39_MOUSE Vam6/Vps39-like protein 4EBP1_MOUSE Eukaryotic translation initiation factor 4E-binding protein 1
EP
Erh Exoc1 Mrpl37 Sin3a
AC C
sp|P84089|ERH_MOUSE sp|Q8R3S6|EXOC1_MOUSE sp|Q921S7|RM37_MOUSE sp|Q60520|SIN3A_MOUSE sp|Q8BH86|CN159_MOUSE sp|P70663|SPRL1_MOUSE sp|Q920B9|SP16H_MOUSE sp|Q8CIT9|SBSN_MOUSE sp|Q9D1B9|RM28_MOUSE sp|Q8R3N1|NOP14_MOUSE sp|Q9CRT8|XPOT_MOUSE sp|Q61072|ADAM9_MOUSE sp|Q5I012|S38AA_MOUSE sp|Q6NS46|RRP5_MOUSE sp|Q80U87|UBP8_MOUSE sp|Q80W00|PP1RA_MOUSE sp|Q9DC29|ABCB6_MOUSE sp|Q80TV8|CLAP1_MOUSE sp|Q61712|DNJC1_MOUSE sp|Q9DC71|RT15_MOUSE sp|Q9CZX9|EMC4_MOUSE sp|O55234|PSB5_MOUSE sp|Q9CRD0|OCAD1_MOUSE sp|Q7TQ95|LNP_MOUSE sp|Q99N57|RAF1_MOUSE sp|P28700|RXRA_MOUSE tr|F8VPK0|F8VPK0_MOUSE sp|P14142|GTR4_MOUSE sp|Q9JKC8|AP3M1_MOUSE sp|Q9QYH6|MAGD1_MOUSE sp|Q6P2B1|TNPO3_MOUSE sp|Q80X85|RT07_MOUSE sp|P83882|RL36A_MOUSE sp|Q8CI71|CC132_MOUSE sp|Q6PHU5|SORT_MOUSE sp|Q99KD5|UN45A_MOUSE sp|Q61990|PCBP2_MOUSE sp|Q8C0L0|TMX4_MOUSE sp|Q8BKT7|THOC5_MOUSE sp|Q8BYL4|SYYM_MOUSE sp|Q7TPD0|INT3_MOUSE sp|Q8BH15|CNO10_MOUSE sp|Q8K301|DDX52_MOUSE tr|B2RXQ2|B2RXQ2_MOUSE sp|Q8K2F8|LS14A_MOUSE sp|Q9R0Q9|MPU1_MOUSE sp|Q61749|EI2BD_MOUSE sp|Q8BWF0|SSDH_MOUSE sp|Q9ES74|NEK7_MOUSE sp|Q9JI10|STK3_MOUSE sp|Q62348|TSN_MOUSE sp|Q8VDT9|RM50_MOUSE sp|Q6PDM2|SRSF1_MOUSE sp|Q9D0J4|ARL2_MOUSE sp|Q80Y81|RNZ2_MOUSE sp|P27601|GNA13_MOUSE sp|P46735|MYO1B_MOUSE sp|B1AZI6|THOC2_MOUSE sp|Q8C166|CPNE1_MOUSE sp|Q9JMH9|MY18A_MOUSE sp|Q8R5L3|VPS39_MOUSE sp|Q60876|4EBP1_MOUSE
354.708 183.203 322.382 216.149 221.268 418.712 252.303 225.571 206.945 374.596 259.239 242.964 206.056 154.477 288.186 423.567 150.635 239.845 190.4 243.002 227.689 319.182 157.24 303.906 228.329 131.777 225.598 392.846 200.27 184.254 229.608 260.378 493.801 154.869 251.156 265.332 117.278 289.128 315.642 251.22 192.862 242.13 206.667 192.289 132.646 322.423 203.568 246.927 292.673 171.366 347.196 397.572 277.97 267.411 190.461 372.524 271.656 231.845 296.979 292.982 231.905 534.966
571.577 332.014 153.2 305.371 282.786 40.1059 161.73 209.838 155.257 453.722 461.497 177.879 86.6857 209.365 359.952 390.344 243.218 248.927 155.097 151.479 237.7 285.171 155.063 276.476 142.148 636.983 348.613 496.651 169.037 121.054 312.454 166.886 254.33 140.565 220.311 314.678 419.753 224.584 318.655 215.694 225.254 291.967 249.332 237.485 218.354 493.305 407.728 152.995 263.446 149.991 359.69 147.567 185.475 241.512 198.577 646.558 418.404 202.654 426.616 148.108 246.148 157.357
1205.88 391.223 199.582 505.066 441.125 218.997 170.593 365.157 241.216 469.585 306.289 124.891 189.553 94.4014 395.395 877.62 136.767 254.666 346.168 199.362 316.464 245.72 170.451 324.3 131.63 551.977 230.658 260.5 130.342 269.546 221.224 398.704 530.073 109.666 214.392 290.988 679.345 201.435 162.679 278.545 190.981 208.71 257.456 305.359 495.803 827.429 179.653 288.926 289.883 202.587 223.699 453.349 473.087 484.795 168.402 487.974 390.735 224.705 542.898 211.412 193.176 241.142
1.49 1.48 1.48 1.44 1.43 1.43 1.41 1.41 1.40 1.40 1.38 1.37 1.36 1.34 1.33 1.32 1.32 1.31 1.30 1.30 1.29 1.28 1.28 1.28 1.26 1.26 1.26 1.25 1.25 1.25 1.24 1.24 1.24 1.24 1.23 1.23 1.22 1.22 1.22 1.22 1.22 1.21 1.21 1.21 1.21 1.21 1.21 1.20 1.20 1.19 1.19 1.19 1.18 1.17 1.17 1.17 1.17 1.17 1.16 1.16 1.16 1.15
4.85 2.00 0.67 2.48 1.89 0.45 0.88 1.85 1.11 1.58 2.18 0.68 0.73 1.22 1.69 1.90 1.56 1.21 1.51 0.72 1.38 1.21 1.07 1.05 0.83 5.02 1.60 0.85 0.85 1.28 1.53 1.16 1.31 0.85 0.93 1.38 5.04 0.79 0.88 1.12 1.09 1.14 1.33 1.41 3.26 2.34 1.53 0.93 1.04 1.10 0.88 0.79 1.43 1.43 0.95 1.51 1.75 1.03 1.54 0.66 1.05 0.42
ACCEPTED MANUSCRIPT
TE D
EP
311.937 179.6 302.929 210.939 129.277 306.194 274.876 304.894 284.408 235.127 177.563 156.172 230.015 168.961 220.262 186.63 370.958 304.739 235.559 249.052 392.149 266.672 240.914 352.707 337.445 233.963 143.94 273.684 282.943 299.204 148.64 175.509 165.38 218.114 198.761 325.81 212.582 207.053 283.248 147.388 238.341 276.67 170.236 251.969 261.594 223.08 306.583 190.386 242.462 337.688 292.474 344.481 179.816 280.421 396.811 376.542 275.892 178.732 273.626 150.81 277.457 264.1
423.493 211.723 479.132 473.154 182.695 428.316 377.38 355.928 410.544 337.913 226.439 227.155 279.828 218.539 283.881 264.714 456.962 322.86 299.395 310.723 470.202 294.266 303.26 417.626 600.587 260.833 187.098 281.916 336.965 174.809 190.78 223.293 251.157 290.074 230.757 405.397 239.327 238.391 260.135 174.892 198.115 345.339 207.08 241.749 327.784 253.161 266.096 259.081 325.912 373.341 282.06 413.901 170.078 336.496 473.546 400.034 336.147 224.017 258.627 162.565 311.531 259.905
RI PT
361.093 179.229 406.144 379.031 147.002 357.387 312.85 302.475 364.852 301.746 191.774 197.945 234.259 193.765 242.291 219.915 371.021 288.051 258.594 277.045 410.096 237.387 254.672 346.925 513.539 205.939 166.309 255.519 307.813 272.553 165.575 209.617 226.044 269.244 209.072 363.509 217.334 223.964 208.119 153.877 143.293 320.492 165.08 239.871 324.534 231.85 211.363 228.575 297.913 344.827 296.049 337.195 181.908 380.588 445.904 343.994 313.452 195.261 288.35 154.435 296.656 282.043
SC
5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
M AN U
Ralgapb RLGPB_MOUSE Ral GTPase-activating protein subunit beta Mtor MTOR_MOUSE Serine/threonine-protein kinase mTOR Wdr91 WDR91_MOUSE WD repeat-containing protein 91 Gyg1 GLYG_MOUSE Glycogenin-1 Nhp2 NHP2_MOUSE H/ACA ribonucleoprotein complex subunit 2 Rnmtl1 RMTL1_MOUSE RNA methyltransferase-like protein 1 Nfia NFIA_MOUSE Nuclear factor 1 A-type Mapkapk2 MAPK2_MOUSE MAP kinase-activated protein kinase 2 Ampd2 AMPD2_MOUSE AMP deaminase 2 Mrps26 RT26_MOUSE 28S ribosomal protein S26, mitochondrial Sltm SLTM_MOUSE SAFB-like transcription modulator Rps6kb1 KS6B1_MOUSE Ribosomal protein S6 kinase beta-1 Lyplal1 LYPL1_MOUSE Lysophospholipase-like protein 1 Celf1 CELF1_MOUSE CUGBP Elav-like family member 1 Lrrc40 LRC40_MOUSE Leucine-rich repeat-containing protein 40 Osbpl11 OSB11_MOUSE Oxysterol-binding protein-related protein 11 Gnptab GNPTA_MOUSE N-acetylglucosamine-1-phosphotransferase subunits alpha/beta Mrpl9 RM09_MOUSE 39S ribosomal protein L9, mitochondrial Herc4 HERC4_MOUSE Probable E3 ubiquitin-protein ligase HERC4 Mrpl19 RM19_MOUSE 39S ribosomal protein L19, mitochondrial Mob1b MOB1B_MOUSE MOB kinase activator 1B 1810009A15RikQ9D937_MOUSE MCG127334 Tsg101 TS101_MOUSE Tumor susceptibility gene 101 protein Cog4 COG4_MOUSE Conserved oligomeric Golgi complex subunit 4 Insr INSR_MOUSE Insulin receptor Ppp1r2 IPP2_MOUSE Protein phosphatase inhibitor 2 Gsk3b GSK3B_MOUSE Glycogen synthase kinase-3 beta CA123_MOUSE UPF0587 protein C1orf123 homolog Trappc12 TPC12_MOUSE Trafficking protein particle complex subunit 12 Slc25a11 M2OM_MOUSE Mitochondrial 2-oxoglutarate/malate carrier protein Bre BRE_MOUSE BRCA1-A complex subunit BRE Spg21 SPG21_MOUSE Maspardin Timm21 TIM21_MOUSE Isoform 2 of Mitochondrial import inner membrane translocase subunit Tim21 Lman2l LMA2L_MOUSE VIP36-like protein Inppl1 SHIP2_MOUSE Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Preb PREB_MOUSE Prolactin regulatory element-binding protein Ufl1 UFL1_MOUSE E3 UFM1-protein ligase 1 Osbpl2 OSBL2_MOUSE Oxysterol-binding protein-related protein 2 Serbp1 PAIRB_MOUSE Isoform 2 of Plasminogen activator inhibitor 1 RNA-binding protein Cnpy4 CNPY4_MOUSE Protein canopy homolog 4 Dnajb1 DNJB1_MOUSE DnaJ homolog subfamily B member 1 Cog7 COG7_MOUSE Conserved oligomeric Golgi complex subunit 7 Cisd3 CISD3_MOUSE CDGSH iron-sulfur domain-containing protein 3, mitochondrial Nolc1 E9Q5C9_MOUSE Protein Nolc1 Acap2 ACAP2_MOUSE Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 Ict1 ICT1_MOUSE Peptidyl-tRNA hydrolase ICT1, mitochondrial Ptms PTMS_MOUSE Parathymosin Ehd4 EHD4_MOUSE EH domain-containing protein 4 Phf3 B2RQG2_MOUSE PHD finger protein 3 Ptpn1 PTN1_MOUSE Tyrosine-protein phosphatase non-receptor type 1 Ankfy1 ANFY1_MOUSE Ankyrin repeat and FYVE domain-containing protein 1 Gpr107 GP107_MOUSE Protein GPR107 Rpia RPIA_MOUSE Ribose-5-phosphate isomerase Mrpl47 RM47_MOUSE 39S ribosomal protein L47, mitochondrial Tmem126b T126B_MOUSE Complex I assembly factor TMEM126B, mitochondrial Gigyf2 PERQ2_MOUSE PERQ amino acid-rich with GYF domain-containing protein 2 Ndufaf1 CIA30_MOUSE Complex I intermediate-associated protein 30, mitochondrial Optn OPTN_MOUSE Optineurin Smarca4 SMCA4_MOUSE Transcription activator BRG1 Hnrnph2 HNRH2_MOUSE Heterogeneous nuclear ribonucleoprotein H2 Ube2o UBE2O_MOUSE Ubiquitin-conjugating enzyme E2 O Stag2 STAG2_MOUSE Cohesin subunit SA-2
AC C
sp|Q8BQZ4|RLGPB_MOUSE sp|Q9JLN9|MTOR_MOUSE sp|Q7TMQ7|WDR91_MOUSE sp|Q9R062|GLYG_MOUSE sp|Q9CRB2|NHP2_MOUSE sp|Q5ND52|RMTL1_MOUSE sp|Q02780|NFIA_MOUSE sp|P49138|MAPK2_MOUSE sp|Q9DBT5|AMPD2_MOUSE sp|Q80ZS3|RT26_MOUSE sp|Q8CH25|SLTM_MOUSE sp|Q8BSK8|KS6B1_MOUSE sp|Q3UFF7|LYPL1_MOUSE sp|P28659|CELF1_MOUSE sp|Q9CRC8|LRC40_MOUSE sp|Q8CI95|OSB11_MOUSE sp|Q69ZN6|GNPTA_MOUSE sp|Q99N94|RM09_MOUSE sp|Q6PAV2|HERC4_MOUSE sp|Q9D338|RM19_MOUSE sp|Q8BPB0|MOB1B_MOUSE tr|Q9D937|Q9D937_MOUSE sp|Q61187|TS101_MOUSE sp|Q8R1U1|COG4_MOUSE sp|P15208|INSR_MOUSE sp|Q9DCL8|IPP2_MOUSE sp|Q9WV60|GSK3B_MOUSE sp|Q8BHG2|CA123_MOUSE sp|Q8K2L8|TPC12_MOUSE sp|Q9CR62|M2OM_MOUSE sp|Q8K3W0|BRE_MOUSE sp|Q9CQC8|SPG21_MOUSE sp|Q8CCM6-2|TIM21_MOUSE sp|P59481|LMA2L_MOUSE sp|Q6P549|SHIP2_MOUSE sp|Q9WUQ2|PREB_MOUSE sp|Q8CCJ3|UFL1_MOUSE sp|Q8BX94|OSBL2_MOUSE sp|Q9CY58-2|PAIRB_MOUSE sp|Q8BQ47|CNPY4_MOUSE sp|Q9QYJ3|DNJB1_MOUSE sp|Q3UM29|COG7_MOUSE sp|B1AR13|CISD3_MOUSE tr|E9Q5C9|E9Q5C9_MOUSE sp|Q6ZQK5|ACAP2_MOUSE sp|Q8R035|ICT1_MOUSE sp|Q9D0J8|PTMS_MOUSE sp|Q9EQP2|EHD4_MOUSE tr|B2RQG2|B2RQG2_MOUSE sp|P35821|PTN1_MOUSE sp|Q810B6|ANFY1_MOUSE sp|Q8BUV8|GP107_MOUSE sp|P47968|RPIA_MOUSE sp|Q8K2Y7|RM47_MOUSE sp|Q9D1R1|T126B_MOUSE sp|Q6Y7W8|PERQ2_MOUSE sp|Q9CWX2|CIA30_MOUSE sp|Q8K3K8|OPTN_MOUSE sp|Q3TKT4|SMCA4_MOUSE sp|P70333|HNRH2_MOUSE sp|Q6ZPJ3|UBE2O_MOUSE sp|O35638|STAG2_MOUSE
349.981 199.433 332.193 199.558 131.142 325.394 289.261 330.896 319.338 264.08 187.444 168.824 238.37 183.904 228.832 185.904 364.585 332.861 246.967 270.19 415.406 261.919 243.159 353.218 336.644 220.147 151.669 294.091 304.203 445.695 150.136 194.254 172.752 236.543 209.85 338.911 224.68 226.669 269.702 149.613 212.714 297.485 152.417 284.981 299.482 232.319 286.001 186.686 246.446 348.632 340.43 305.135 211.315 357.298 409.481 353.643 279.822 166.728 326.472 154.56 284.59 305.166
264.909 267.617 297.521 248.248 388.486 86.7108 275.716 271.297 340.345 132.728 174.263 190.204 162.386 328.514 252.162 209.347 286.02 132.222 244.61 283.362 477.007 196.069 216.688 464.838 395.821 130.442 173.416 245.83 241.47 306.571 304.976 176.797 226.198 209.017 267.059 482.325 213.726 242.018 204.472 164.018 307.505 266.159 240.608 232.835 239.655 157.409 150.464 231.601 261.56 380.635 532.312 352.163 108.105 128.063 239.107 249.954 149.824 149.872 350.101 346.333 348.013 239.152
324.368 223.708 315.948 641.594 420.293 357.004 338.259 294.064 265.708 207.425 314.763 223.792 241.185 374.326 233.573 257.64 527.947 346.406 238.464 344.799 461.252 331.797 250.171 291.516 350.823 334.844 162.698 584.61 312.948 259.241 259.278 155.368 145.422 209.597 382.668 328.198 152.791 242.373 443.414 228.306 409.88 227.86 329.51 322.116 228.056 419.341 820.835 239.613 456.685 583.594 691.937 331.774 116.8 317.863 276.341 602.051 355.416 275.14 362.469 510.401 339.225 170.869
1.15 1.15 1.14 1.14 1.14 1.14 1.13 1.13 1.12 1.12 1.12 1.12 1.12 1.11 1.11 1.11 1.11 1.11 1.11 1.10 1.10 1.10 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.03
0.88 1.37 0.87 1.51 2.93 0.67 1.04 0.93 0.93 0.63 1.32 1.17 0.87 1.94 1.05 1.15 1.10 0.81 0.98 1.19 1.17 1.05 0.94 1.08 0.88 1.06 1.08 1.57 0.94 0.99 1.80 0.86 0.95 0.86 1.59 1.18 0.85 1.12 1.32 1.30 1.88 0.83 1.70 1.13 0.80 1.27 1.88 1.12 1.33 1.41 2.08 1.00 0.62 0.67 0.61 1.18 0.86 1.14 1.27 2.81 1.20 0.75
ACCEPTED MANUSCRIPT
TE D
218.775 257.996 186.786 271.395 347.372 273.919 216.62 304.337 181.646 401.523 325.083 381.648 233.646 218.22 343.621 163.158 297.73 293.476 255.148 141.65 391.078 159.631 218.268 180.582 237.217 274.721 220.736 194.836 375.807 261.806 369.711 257.606 184.052 205.697 364.627 134.283 358.609 417.043 231.133 321.054 95.9821 430.546 187.041 413.462 297.4 166.392 240.383 312.741 204.711 237.201 265.603 208.362 333.043 261.242 182.458 234.392 215.885 389.303 202.329 176.126 115.584 649.668
260.377 265.922 206.443 297.764 372.662 334.886 198.257 380.688 177.407 338.947 312.002 369.09 255.147 261.467 371.173 225.228 300.22 310.568 339.23 149.68 492.787 192.826 268.607 226.439 248.638 245.663 215.552 213.52 415.238 329.73 431.13 262.434 202.814 215.569 416.942 131.104 431.953 467.234 219.928 337.121 93.5175 489.318 189.512 435.31 293.924 194.698 294.033 302.956 221.902 207.755 344.357 214.16 318.978 268.79 189.464 227.287 210.835 445.959 222.275 225.602 109.771 602.651
RI PT
236.876 228.439 200.217 297.361 332.51 317.868 232.009 353.356 192.609 344.399 336.904 329.872 212.878 272.256 362.893 201.139 261.27 284.234 347.728 133.967 454.651 167.009 230.757 261.723 213.973 280.252 190.54 210.111 345.984 344.986 404.755 233.234 237.759 198.514 401.978 110.311 394.523 462.392 202.471 333.176 100.337 499.032 197.774 419.2 260.25 223.134 291.526 311.844 205.051 227.059 344.48 232.202 283.622 290.369 193.215 262.993 183.826 407.947 249.749 224.299 124.365 547.096
SC
5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
M AN U
NISCH_MOUSE Nischarin PARVA_MOUSE Alpha-parvin E9QAS7_MOUSE Protein Inpp5a TGBR3_MOUSE Transforming growth factor beta receptor type 3 E9Q3E1_MOUSE Aldehyde dehydrogenase MTMR1_MOUSE Myotubularin-related protein 1 OFUT2_MOUSE GDP-fucose protein O-fucosyltransferase 2 STX8_MOUSE Syntaxin-8 FXR1_MOUSE Fragile X mental retardation syndrome-related protein 1 SYPL1_MOUSE Synaptophysin-like protein 1 TMED5_MOUSE Transmembrane emp24 domain-containing protein 5 RM32_MOUSE 39S ribosomal protein L32, mitochondrial HRSL3_MOUSE HRAS-like suppressor 3 AKT1_MOUSE RAC-alpha serine/threonine-protein kinase ZN598_MOUSE Zinc finger protein 598 RAB3A_MOUSE Ras-related protein Rab-3A LRRF2_MOUSE Leucine-rich repeat flightless-interacting protein 2 SHC1_MOUSE SHC-transforming protein 1 ASGL1_MOUSE Isoaspartyl peptidase/L-asparaginase MED21_MOUSE Mediator of RNA polymerase II transcription subunit 21 UCK1_MOUSE Uridine-cytidine kinase 1 RPRD2_MOUSE Regulation of nuclear pre-mRNA domain-containing protein 2 DCXR_MOUSE L-xylulose reductase NAKD2_MOUSE NAD kinase 2, mitochondrial DJC24_MOUSE DnaJ homolog subfamily C member 24 PI3R4_MOUSE Phosphoinositide 3-kinase regulatory subunit 4 D3Z285_MOUSE NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (Fragment) SUOX_MOUSE Sulfite oxidase, mitochondrial A2AR76_MOUSE TRAF family member-associated NF-kappa-B activator SNX4_MOUSE Sorting nexin-4 RNT2_MOUSE Ribonuclease T2 TRIP4_MOUSE Activating signal cointegrator 1 RBM22_MOUSE Pre-mRNA-splicing factor RBM22 E9PWM3_MOUSE Protein Armcx4 MOCS1_MOUSE Molybdenum cofactor biosynthesis protein 1 SORCN_MOUSE Sorcin COMD1_MOUSE COMM domain-containing protein 1 NMRL1_MOUSE NmrA-like family domain-containing protein 1 PEA15_MOUSE Astrocytic phosphoprotein PEA-15 CHERP_MOUSE Calcium homeostasis endoplasmic reticulum protein PEG10_MOUSE Retrotransposon-derived protein PEG10 ADH1_MOUSE Alcohol dehydrogenase 1 COG2_MOUSE Conserved oligomeric Golgi complex subunit 2 SPF45_MOUSE Splicing factor 45 CSTF2_MOUSE Cleavage stimulation factor subunit 2 CAF17_MOUSE Putative transferase CAF17 homolog, mitochondrial CECR5_MOUSE Cat eye syndrome critical region protein 5 homolog LSG1_MOUSE Large subunit GTPase 1 homolog SASH1_MOUSE SAM and SH3 domain-containing protein 1 OTUB1_MOUSE Ubiquitin thioesterase OTUB1 ATPF2_MOUSE ATP synthase mitochondrial F1 complex assembly factor 2 UIF_MOUSE UAP56-interacting factor HEM4_MOUSE Uroporphyrinogen-III synthase RBNS5_MOUSE Rabenosyn-5 BABA1_MOUSE BRISC and BRCA1-A complex member 1 CPT1A_MOUSE Carnitine O-palmitoyltransferase 1, liver isoform ATF2_MOUSE Cyclic AMP-dependent transcription factor ATF-2 ENPP5_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 KBP_MOUSE KIF1-binding protein PRP31_MOUSE U4/U6 small nuclear ribonucleoprotein Prp31 PP1B_MOUSE Serine/threonine-protein phosphatase PP1-beta catalytic subunit CPIN1_MOUSE Anamorsin
EP
Nisch Parva Inpp5a Tgfbr3 Aldh3b2 Mtmr1 Pofut2 Stx8 Fxr1 Sypl1 Tmed5 Mrpl32 Pla2g16 Akt1 Znf598 Rab3a Lrrfip2 Shc1 Asrgl1 Med21 Uck1 Rprd2 Dcxr Nadk2 Dnajc24 Pik3r4 Nfu1 Suox Tank Snx4 Rnaset2 Trip4 Rbm22 Armcx4 Mocs1 Sri Commd1 Nmral1 Pea15 Cherp Peg10 Adh1 Cog2 Rbm17 Cstf2 Iba57 Cecr5 Lsg1 Sash1 Otub1 Atpaf2 Fyttd1 Uros Zfyve20 Babam1 Cpt1a Atf2 Enpp5 Kbp Prpf31 Ppp1cb Ciapin1
AC C
sp|Q80TM9|NISCH_MOUSE sp|Q9EPC1|PARVA_MOUSE tr|E9QAS7|E9QAS7_MOUSE sp|O88393|TGBR3_MOUSE tr|E9Q3E1|E9Q3E1_MOUSE sp|Q9Z2C4|MTMR1_MOUSE sp|Q8VHI3|OFUT2_MOUSE sp|O88983|STX8_MOUSE sp|Q61584|FXR1_MOUSE sp|O09117|SYPL1_MOUSE sp|Q9CXE7|TMED5_MOUSE sp|Q9DCI9|RM32_MOUSE sp|Q8R3U1|HRSL3_MOUSE sp|P31750|AKT1_MOUSE sp|Q80YR4|ZN598_MOUSE sp|P63011|RAB3A_MOUSE sp|Q91WK0|LRRF2_MOUSE sp|P98083|SHC1_MOUSE sp|Q8C0M9|ASGL1_MOUSE sp|Q9CQ39|MED21_MOUSE sp|P52623|UCK1_MOUSE sp|Q6NXI6|RPRD2_MOUSE sp|Q91X52|DCXR_MOUSE sp|Q8C5H8|NAKD2_MOUSE sp|Q91ZF0|DJC24_MOUSE sp|Q8VD65|PI3R4_MOUSE tr|D3Z285|D3Z285_MOUSE sp|Q8R086|SUOX_MOUSE tr|A2AR76|A2AR76_MOUSE sp|Q91YJ2|SNX4_MOUSE sp|Q9CQ01|RNT2_MOUSE sp|Q9QXN3|TRIP4_MOUSE sp|Q8BHS3|RBM22_MOUSE tr|E9PWM3|E9PWM3_MOUSE sp|Q5RKZ7|MOCS1_MOUSE sp|Q6P069|SORCN_MOUSE sp|Q8K4M5|COMD1_MOUSE sp|Q8K2T1|NMRL1_MOUSE sp|Q62048|PEA15_MOUSE sp|Q8CGZ0|CHERP_MOUSE sp|Q7TN75|PEG10_MOUSE sp|P00329|ADH1_MOUSE sp|Q921L5|COG2_MOUSE sp|Q8JZX4|SPF45_MOUSE sp|Q8BIQ5|CSTF2_MOUSE sp|Q8CAK1|CAF17_MOUSE sp|Q91WM2|CECR5_MOUSE sp|Q3UM18|LSG1_MOUSE sp|P59808|SASH1_MOUSE sp|Q7TQI3|OTUB1_MOUSE sp|Q91YY4|ATPF2_MOUSE sp|Q91Z49|UIF_MOUSE sp|P51163|HEM4_MOUSE sp|Q80Y56|RBNS5_MOUSE sp|Q3UI43|BABA1_MOUSE sp|P97742|CPT1A_MOUSE sp|P16951|ATF2_MOUSE sp|Q9EQG7|ENPP5_MOUSE sp|Q6ZPU9|KBP_MOUSE sp|Q8CCF0|PRP31_MOUSE sp|P62141|PP1B_MOUSE sp|Q8WTY4|CPIN1_MOUSE
210.754 236.246 191.085 286.262 324.841 272.138 261.345 289.749 203.777 420.269 360.096 352.843 196.763 233.822 341.657 141.565 261.625 266.664 261.7 124.917 348.751 131.718 176.585 211.146 196.325 301.393 189.649 184.935 294.143 266.102 328.956 219.229 210.718 180.423 333.288 107.682 302.928 390.414 200.489 296.13 96.2373 408.217 181.83 368.018 242.786 179.746 217.278 297.032 171.336 236.981 238.456 206.456 269.443 257.264 167.302 244.386 167.395 306.567 203.977 151.556 114.93 512.563
500.94 251.406 183.544 230.631 279.324 196.892 248.61 180.07 381.679 398.679 437.462 206.586 166.693 230.386 328.671 422.119 259.87 300.921 222.519 83.1185 284.394 198.077 213.422 259.014 310.472 392.936 212.964 159.368 205.495 303.176 252.141 241.748 284.45 145.316 239.674 765.366 356.173 323.711 131.494 400.453 867.703 250.613 238.049 469.651 270.237 169.373 262.607 335.252 161.777 199.762 240.931 80.8261 194.79 339.401 386.333 297.44 138.319 282.811 220.348 226.562 245.565 561.52
449.687 238.932 165.958 298.182 358.706 224.015 171.287 233.404 342.985 318.213 439.094 652.631 407.241 276.705 449.877 428.232 582.614 658.333 364.701 238.733 323.826 210.746 271.022 248.058 782.463 360.324 470.365 339.753 508.916 273.596 597.913 578.976 342.668 312.392 361.109 1162.26 407.476 486.56 232.281 661.128 336.495 329.949 257.057 1008.66 535.027 176.566 528.058 373.15 307.221 180.756 307.875 195.026 430.619 404.398 441.925 182.896 250.919 373.042 221.308 192.932 264.439 1104.49
1.03 1.03 1.03 1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.95 0.95 0.94 0.94 0.94 0.94 0.93
2.09 1.01 0.90 0.93 0.94 0.71 0.94 0.63 1.94 0.96 1.32 1.21 1.29 1.03 1.10 2.33 1.51 1.66 0.97 1.17 0.72 1.25 1.08 1.15 2.42 1.36 1.66 1.23 0.99 0.95 1.10 1.67 1.49 1.13 0.78 7.88 1.01 0.92 0.84 1.62 6.13 0.62 1.29 1.78 1.44 0.89 1.49 1.13 1.14 0.82 0.90 0.63 1.01 1.35 2.20 0.97 0.97 0.82 0.98 1.05 2.13 1.39
ACCEPTED MANUSCRIPT
177.942 327.024 313.766 224.997 293.764 249.133 248.038 431.269 330.055 273.085 183.59 224.659 125.804 321.566 301.972 447.331 315.793 283.125 279.185 251.341 170.386 197.644 246.223 297.629 233.689 234.334 247.833 333.923 276.696 277.289 285.39 283.689 227.77 495.137 203.468 446.755 139.961 163.57 347.843 142.005 137.223 236.406 379.293 222.256 278.136 398.63 310.031 348.942 89.6253 0.00998063 54.9463 115.39 154.144 105.355 135.995 227.098 88.7742 164.395 262.331 151.707 133.226 100.958
156.066 337.418 265.312 224.394 270.452 246.122 251.037 344.709 253.664 261.591 174.223 209.875 117.658 336.927 211.922 436.639 294.939 281.298 271.46 236.709 144.656 152.201 225.774 259.974 242.128 183.673 193.045 315.846 219.57 263.257 253.779 261.792 237.715 505.128 172.097 414.164 145.692 153.675 262.02 117.083 139.292 202.075 315.374 206.87 263.299 302.563 232.233 206.435 573.255 8.4784 196.113 318.029 449.192 221.167 296.752 364.599 244.728 411.916 364.546 226.39 237.41 211.951
RI PT
177.336 366.859 290.816 265.17 293.782 240.587 225.376 344.806 248.106 284.81 238.131 196.055 103.811 357.828 203.436 501.183 326.259 320.629 327.414 248.94 139.219 227.272 264.272 339.521 264.004 195.48 220.823 311.401 202.844 305.48 261.321 251.144 321.976 568.27 166.327 460.141 169.156 183.129 292.792 162.018 163.364 266.083 378.885 258.431 337.401 545.97 415.825 384.758 80.1184 3.06685 84.9684 144.469 188.499 118.413 81.2039 171.271 140.793 181.995 231.032 163.458 157.803 123.61
SC
5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 4 4 4 4 4 4 4 4 4 4 4 4 4 4
M AN U
TE D
Ndrg1 Mat2b Cltb Tardbp Ccdc25 Tmcc3 Strip1 Vps4a Sf3b4 Kiaa0196 Capza1 Gna11 Sh3bp1 Lrrfip1 Ftl1 Cd99l2 Dnajb4 Fggy Lxn Dnajb9 Prcp Nid1 Gpatch8 Cdkn2c Cbwd1 Bag1 Tjp2 Ppp2cb Tsc22d3 Purb Prkab2 Gpt2 Papola Prpf38b Manba Impa2 Ca2 Cnbp Ptn Akr1c14 Naalad2 Dclk1 Ndufa12 Apoc1 Clec2d Mrps18a Tmem87a Pfkfb1 Fads1 Plgrkt
DCAF8_MOUSE DDB1- and CUL4-associated factor 8 UBCP1_MOUSE Ubiquitin-like domain-containing CTD phosphatase 1 HEXI1_MOUSE Protein HEXIM1 KIF2A_MOUSE Kinesin-like protein KIF2A TGON1_MOUSE Trans-Golgi network integral membrane protein 1 MFR1L_MOUSE Mitochondrial fission regulator 1-like CRK_MOUSE Adapter molecule crk TAXB1_MOUSE Tax1-binding protein 1 homolog DNJB6_MOUSE Isoform B of DnaJ homolog subfamily B member 6 LTOR3_MOUSE Ragulator complex protein LAMTOR3 MCAT_MOUSE Mitochondrial carnitine/acylcarnitine carrier protein CI078_MOUSE Uncharacterized protein C9orf78 homolog NDRG1_MOUSE Protein NDRG1 MAT2B_MOUSE Methionine adenosyltransferase 2 subunit beta CLCB_MOUSE Isoform 2 of Clathrin light chain B TADBP_MOUSE TAR DNA-binding protein 43 CCD25_MOUSE Coiled-coil domain-containing protein 25 TMCC3_MOUSE Transmembrane and coiled-coil domains protein 3 STRP1_MOUSE Striatin-interacting protein 1 VPS4A_MOUSE Vacuolar protein sorting-associated protein 4A SF3B4_MOUSE Splicing factor 3B subunit 4 STRUM_MOUSE WASH complex subunit strumpellin Q5RKN9_MOUSE Capping protein (Actin filament) muscle Z-line, alpha 1 GNA11_MOUSE Guanine nucleotide-binding protein subunit alpha-11 3BP1_MOUSE SH3 domain-binding protein 1 LRRF1_MOUSE Leucine-rich repeat flightless-interacting protein 1 Q9CPX4_MOUSE Ferritin C99L2_MOUSE CD99 antigen-like protein 2 DNJB4_MOUSE DnaJ homolog subfamily B member 4 FGGY_MOUSE FGGY carbohydrate kinase domain-containing protein LXN_MOUSE Latexin DNJB9_MOUSE DnaJ homolog subfamily B member 9 PCP_MOUSE Lysosomal Pro-X carboxypeptidase NID1_MOUSE Nidogen-1 GPTC8_MOUSE G patch domain-containing protein 8 CDN2C_MOUSE Cyclin-dependent kinase 4 inhibitor C CBWD1_MOUSE COBW domain-containing protein 1 BAG1_MOUSE BAG family molecular chaperone regulator 1 ZO2_MOUSE Tight junction protein ZO-2 PP2AB_MOUSE Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform T22D3_MOUSE Isoform 3 of TSC22 domain family protein 3 PURB_MOUSE Transcriptional activator protein Pur-beta AAKB2_MOUSE 5'-AMP-activated protein kinase subunit beta-2 ALAT2_MOUSE Alanine aminotransferase 2 E9QAN2_MOUSE Poly(A) polymerase alpha PR38B_MOUSE Pre-mRNA-splicing factor 38B MANBA_MOUSE Beta-mannosidase IMPA2_MOUSE Inositol monophosphatase 2 CAH2_MOUSE Carbonic anhydrase 2 CNBP_MOUSE Isoform 2 of Cellular nucleic acid-binding protein PTN_MOUSE Pleiotrophin Q91WT7_MOUSE 3-alpha-hydroxysteroid dehydrogenase type 1 NALD2_MOUSE N-acetylated-alpha-linked acidic dipeptidase 2 DCLK1_MOUSE Serine/threonine-protein kinase DCLK1 NDUAC_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 APOC1_MOUSE Apolipoprotein C-I CLC2D_MOUSE C-type lectin domain family 2 member D RT18A_MOUSE 28S ribosomal protein S18a, mitochondrial TM87A_MOUSE Transmembrane protein 87A F261_MOUSE 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 FADS1_MOUSE Fatty acid desaturase 1 PLRKT_MOUSE Plasminogen receptor (KT)
EP
Dcaf8 Ublcp1 Hexim1 Kif2a Tgoln1 Mtfr1l Crk Tax1bp1 Dnajb6 Lamtor3 Slc25a20
AC C
sp|Q8N7N5|DCAF8_MOUSE sp|Q8BGR9|UBCP1_MOUSE sp|Q8R409|HEXI1_MOUSE sp|P28740|KIF2A_MOUSE sp|Q62313|TGON1_MOUSE sp|Q9CWE0|MFR1L_MOUSE sp|Q64010|CRK_MOUSE sp|Q3UKC1|TAXB1_MOUSE sp|O54946-2|DNJB6_MOUSE sp|O88653|LTOR3_MOUSE sp|Q9Z2Z6|MCAT_MOUSE sp|Q3TQI7|CI078_MOUSE sp|Q62433|NDRG1_MOUSE sp|Q99LB6|MAT2B_MOUSE sp|Q6IRU5-2|CLCB_MOUSE sp|Q921F2|TADBP_MOUSE sp|Q78PG9|CCD25_MOUSE sp|Q8R310|TMCC3_MOUSE sp|Q8C079|STRP1_MOUSE sp|Q8VEJ9|VPS4A_MOUSE sp|Q8QZY9|SF3B4_MOUSE sp|Q8C2E7|STRUM_MOUSE tr|Q5RKN9|Q5RKN9_MOUSE sp|P21278|GNA11_MOUSE sp|P55194|3BP1_MOUSE sp|Q3UZ39|LRRF1_MOUSE tr|Q9CPX4|Q9CPX4_MOUSE sp|Q8BIF0|C99L2_MOUSE sp|Q9D832|DNJB4_MOUSE sp|A2AJL3|FGGY_MOUSE sp|P70202|LXN_MOUSE sp|Q9QYI6|DNJB9_MOUSE sp|Q7TMR0|PCP_MOUSE sp|P10493|NID1_MOUSE sp|A2A6A1|GPTC8_MOUSE sp|Q60772|CDN2C_MOUSE sp|Q8VEH6|CBWD1_MOUSE sp|Q60739|BAG1_MOUSE sp|Q9Z0U1|ZO2_MOUSE sp|P62715|PP2AB_MOUSE sp|Q9Z2S7-3|T22D3_MOUSE sp|O35295|PURB_MOUSE sp|Q6PAM0|AAKB2_MOUSE sp|Q8BGT5|ALAT2_MOUSE tr|E9QAN2|E9QAN2_MOUSE sp|Q80SY5|PR38B_MOUSE sp|Q8K2I4|MANBA_MOUSE sp|Q91UZ5|IMPA2_MOUSE sp|P00920|CAH2_MOUSE sp|P53996-2|CNBP_MOUSE sp|P63089|PTN_MOUSE tr|Q91WT7|Q91WT7_MOUSE sp|Q9CZR2|NALD2_MOUSE sp|Q9JLM8|DCLK1_MOUSE sp|Q7TMF3|NDUAC_MOUSE sp|P34928|APOC1_MOUSE sp|Q91V08|CLC2D_MOUSE sp|Q99N85|RT18A_MOUSE sp|Q8BXN9|TM87A_MOUSE sp|P70266|F261_MOUSE sp|Q920L1|FADS1_MOUSE sp|Q9D3P8|PLRKT_MOUSE
174.025 306.949 295.732 230.005 273.872 205.379 185.242 368.494 277.389 250.017 212.143 174.959 90.2002 276.28 244.158 415.454 276.005 254.714 265.299 205.517 128.137 221.448 222.536 291.17 187.88 187.58 210.529 239.448 192.694 236.197 213.306 194.591 228.445 394.952 134.59 336.278 108.399 131.118 262.023 131.181 105.788 199.025 250.632 136.027 155.485 321.909 205.626 198.202 523.998 5.66532 127.467 276.894 312.494 257.674 161.256 421.769 142.018 167.626 419.948 269.955 215.59 128.038
356.573 239.787 203.469 248.962 301.667 237.769 201.874 320.771 246.455 187.682 417.434 122.617 879.267 292.629 139.636 718.906 272.774 233.404 472.001 164.347 117.556 183.369 214.99 355.933 299.721 195.867 443.178 105.201 315.772 226.99 384.115 70.9439 200.851 211.799 163.917 227.282 205.479 146.321 201.659 256.361 55.5726 423.552 331.531 842.571 158.73 298.082 257.933 484.659 118.737 424.783 3.93245 93.6262 138.46 213.931 220.235 65.8217 126.909 55.9888 340.605 88.8336 82.6144 680.272
426.984 261.585 307.098 225.205 375.943 405.069 391.027 637.617 631.977 242.442 273.038 260.678 211.109 462.957 489.407 879.081 574.38 297.363 342.12 295.87 244.218 170.533 360.721 286.736 238.252 324.948 359.979 237.434 567.696 224.161 571.699 198.575 149.694 454.389 344.84 600.012 314.844 319.609 433.592 428.075 168.443 613.97 553.371 796.457 452.842 277.356 123.942 338.527 92.5166 2002.87 6.67455 101.186 76.5374 172.574 149.476 268.133 115.995 178.13 186.989 95.2313 76.5349 243.819
0.93 0.93 0.93 0.93 0.93 0.92 0.92 0.92 0.92 0.92 0.92 0.91 0.91 0.90 0.90 0.90 0.89 0.89 0.88 0.88 0.88 0.88 0.88 0.87 0.86 0.86 0.86 0.86 0.86 0.86 0.85 0.85 0.85 0.85 0.83 0.83 0.82 0.82 0.82 0.82 0.82 0.80 0.75 0.71 0.68 0.66 0.60 0.55 6.46 4.60 2.31 2.29 2.22 2.14 2.11 1.97 1.68 1.67 1.59 1.57 1.56 1.51
2.21 0.72 0.84 0.97 1.15 1.31 1.25 1.23 1.52 0.77 1.64 0.91 4.75 1.11 1.24 1.68 1.32 0.88 1.34 0.92 1.17 0.83 1.13 1.01 1.08 1.21 1.71 0.53 1.84 0.77 1.75 0.50 0.64 0.63 1.38 0.91 1.68 1.34 0.99 2.25 0.75 2.06 1.17 3.41 0.99 0.61 0.53 1.12 1.24 789.01 0.08 0.75 0.63 1.73 1.70 0.84 1.06 0.68 1.07 0.58 0.55 4.11
ACCEPTED MANUSCRIPT
123.458 100.666 299.63 201.97 112.985 210.904 122.333 140.446 146.239 294.079 192.712 219.009 135.345 156.385 234.888 248.882 153.519 181.661 146 60.6336 184.344 195.699 113.203 167.807 154.958 83.6061 126.755 109.275 106.051 260.871 167.97 183.042 128.8 170.871 224.56 142.59 234.54 155.593 35.6971 115.289 212.708 230.15 334.314 300.561 207.898 115.696 98.8473 238.138 213.729 236.722 243.751 167.71 243.133 346.952 186.809 179.529 250.779 189.787 138.823 95.9806 130.21 222.983
219.842 161.248 438.53 359.788 274.393 230.946 195.77 249.649 254.679 566.8 175.931 370.213 198.019 267.433 337.359 308.779 151.778 301.908 220.239 86.8648 233.523 231.917 179.32 282.29 235.219 160.536 154.394 168.915 180.539 363.973 255.106 305.293 201.619 251.759 283.806 197.198 322.874 245.509 54.9944 171.607 348.16 335.335 444.238 443.026 172.158 183.45 144.634 324.591 291.913 313.81 382.433 230.658 284.628 348.867 304.881 260.764 379.602 252.434 195.764 132.553 214.858 288.09
RI PT
151.543 102.911 276.165 219.488 175.356 183.349 110.927 160.875 157.742 351.69 143.655 251.261 159.576 175.044 217.725 130.299 117.616 213.569 138.917 60.9562 155.49 153.399 125.537 211.556 161.648 115.687 118.853 111.35 123.609 247.514 193.159 241.875 164.586 174.676 187.799 136.36 238.329 185.565 38.6049 143.307 266.466 268.236 301.725 324.051 168.289 147.067 109.274 241.187 234.975 188.929 276.031 192.541 220.2 265.142 229.91 187.947 315.567 215.772 161.127 95.5542 175.261 237.915
SC
4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
M AN U
TE D
Ndufb3 Cnpy2 Mrpl16 Dgat1 Gtpbp10 Exoc3 H2afz Pex11a Gbp6 Fam3c Rhob Ubr3 Marcksl1 Prps1 Tmco1 Ascc3 Tbc1d5 Camk2d Rfc4 Zfr Noc3l Spcs3 Mrpl45 Ndufb8 Stat6 Mprip Fam98b Tex2 Inpp1 Tmem63a Exoc7 Dpm1 Osbpl8 Polr1a Acbd5 Gabarapl1 Dnm1l Pdk1 Myo9b Tor1b Ntpcr Rab5a Cotl1 Ebna1bp2 Mrpl30 Pik3c3 Memo1 Lipa Mrc2 Abhd10 Fam45a Aimp2 Eftud1
SYF1_MOUSE Pre-mRNA-splicing factor SYF1 GRIN3_MOUSE G protein-regulated inducer of neurite outgrowth 3 RBCC1_MOUSE RB1-inducible coiled-coil protein 1 MOV10_MOUSE Putative helicase MOV-10 TBC13_MOUSE TBC1 domain family member 13 DHRS7_MOUSE Dehydrogenase/reductase SDR family member 7 RT34_MOUSE 28S ribosomal protein S34, mitochondrial SPB1_MOUSE pre-rRNA processing protein FTSJ3 CS052_MOUSE Uncharacterized protein C19orf52 homolog NDUB3_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 CNPY2_MOUSE Protein canopy homolog 2 RM16_MOUSE 39S ribosomal protein L16, mitochondrial DGAT1_MOUSE Diacylglycerol O-acyltransferase 1 GTPBA_MOUSE GTP-binding protein 10 EXOC3_MOUSE Exocyst complex component 3 H2AZ_MOUSE Histone H2A.Z PX11A_MOUSE Peroxisomal membrane protein 11A L7N1X8_MOUSE Protein Gbp6 FAM3C_MOUSE Protein FAM3C RHOB_MOUSE Rho-related GTP-binding protein RhoB UBR3_MOUSE E3 ubiquitin-protein ligase UBR3 MRP_MOUSE MARCKS-related protein PRPS1_MOUSE Ribose-phosphate pyrophosphokinase 1 TMCO1_MOUSE Transmembrane and coiled-coil domain-containing protein 1 ASCC3_MOUSE Activating signal cointegrator 1 complex subunit 3 TBCD5_MOUSE TBC1 domain family member 5 KCC2D_MOUSE Calcium/calmodulin-dependent protein kinase type II subunit delta RFC4_MOUSE Replication factor C subunit 4 ZFR_MOUSE Zinc finger RNA-binding protein NOC3L_MOUSE Nucleolar complex protein 3 homolog Q6ZWQ7_MOUSE Signal peptidase complex subunit 3 RM45_MOUSE 39S ribosomal protein L45, mitochondrial NDUB8_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial STAT6_MOUSE Signal transducer and transcription activator 6 MPRIP_MOUSE Myosin phosphatase Rho-interacting protein FA98B_MOUSE Protein FAM98B TEX2_MOUSE Testis-expressed sequence 2 protein INPP_MOUSE Inositol polyphosphate 1-phosphatase TM63A_MOUSE Transmembrane protein 63A EXOC7_MOUSE Exocyst complex component 7 DPM1_MOUSE Dolichol-phosphate mannosyltransferase subunit 1 B9EJ86_MOUSE Oxysterol-binding protein RPA1_MOUSE DNA-directed RNA polymerase I subunit RPA1 ACBD5_MOUSE Acyl-CoA-binding domain-containing protein 5 GBRL1_MOUSE Gamma-aminobutyric acid receptor-associated protein-like 1 DNM1L_MOUSE Isoform 3 of Dynamin-1-like protein PDK1_MOUSE [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial MYO9B_MOUSE Unconventional myosin-IXb TOR1B_MOUSE Torsin-1B NTPCR_MOUSE Cancer-related nucleoside-triphosphatase homolog RAB5A_MOUSE Ras-related protein Rab-5A COTL1_MOUSE Coactosin-like protein EBP2_MOUSE Probable rRNA-processing protein EBP2 RM30_MOUSE 39S ribosomal protein L30, mitochondrial PK3C3_MOUSE Phosphatidylinositol 3-kinase catalytic subunit type 3 MEMO1_MOUSE Protein MEMO1 LICH_MOUSE Lysosomal acid lipase/cholesteryl ester hydrolase MRC2_MOUSE C-type mannose receptor 2 ABHDA_MOUSE Mycophenolic acid acyl-glucuronide esterase, mitochondrial FA45A_MOUSE Protein FAM45A AIMP2_MOUSE Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 ETUD1_MOUSE Elongation factor Tu GTP-binding domain-containing protein 1
EP
Xab2 Gprin3 Rb1cc1 Mov10 Tbc1d13 Dhrs7 Mrps34 Ftsj3
AC C
sp|Q9DCD2|SYF1_MOUSE sp|Q8BWS5|GRIN3_MOUSE sp|Q9ESK9|RBCC1_MOUSE sp|P23249|MOV10_MOUSE sp|Q8R3D1|TBC13_MOUSE sp|Q9CXR1|DHRS7_MOUSE sp|Q9JIK9|RT34_MOUSE sp|Q9DBE9|SPB1_MOUSE sp|Q8BGX2|CS052_MOUSE sp|Q9CQZ6|NDUB3_MOUSE sp|Q9QXT0|CNPY2_MOUSE sp|Q99N93|RM16_MOUSE sp|Q9Z2A7|DGAT1_MOUSE sp|Q8K013|GTPBA_MOUSE sp|Q6KAR6|EXOC3_MOUSE sp|P0C0S6|H2AZ_MOUSE sp|Q9Z211|PX11A_MOUSE tr|L7N1X8|L7N1X8_MOUSE sp|Q91VU0|FAM3C_MOUSE sp|P62746|RHOB_MOUSE sp|Q5U430|UBR3_MOUSE sp|P28667|MRP_MOUSE sp|Q9D7G0|PRPS1_MOUSE sp|Q921L3|TMCO1_MOUSE sp|E9PZJ8|ASCC3_MOUSE sp|Q80XQ2|TBCD5_MOUSE sp|Q6PHZ2|KCC2D_MOUSE sp|Q99J62|RFC4_MOUSE sp|O88532|ZFR_MOUSE sp|Q8VI84|NOC3L_MOUSE tr|Q6ZWQ7|Q6ZWQ7_MOUSE sp|Q9D0Q7|RM45_MOUSE sp|Q9D6J5|NDUB8_MOUSE sp|P52633|STAT6_MOUSE sp|P97434|MPRIP_MOUSE sp|Q80VD1|FA98B_MOUSE sp|Q6ZPJ0|TEX2_MOUSE sp|P49442|INPP_MOUSE sp|Q91YT8|TM63A_MOUSE sp|O35250|EXOC7_MOUSE sp|O70152|DPM1_MOUSE tr|B9EJ86|B9EJ86_MOUSE sp|O35134|RPA1_MOUSE sp|Q5XG73|ACBD5_MOUSE sp|Q8R3R8|GBRL1_MOUSE sp|Q8K1M6-3|DNM1L_MOUSE sp|Q8BFP9|PDK1_MOUSE sp|Q9QY06|MYO9B_MOUSE sp|Q9ER41|TOR1B_MOUSE sp|Q9CQA9|NTPCR_MOUSE sp|Q9CQD1|RAB5A_MOUSE sp|Q9CQI6|COTL1_MOUSE sp|Q9D903|EBP2_MOUSE sp|Q9D7N6|RM30_MOUSE sp|Q6PF93|PK3C3_MOUSE sp|Q91VH6|MEMO1_MOUSE sp|Q9Z0M5|LICH_MOUSE sp|Q64449|MRC2_MOUSE sp|Q6PE15|ABHDA_MOUSE sp|Q9D8N2|FA45A_MOUSE sp|Q8R010|AIMP2_MOUSE sp|Q8C0D5|ETUD1_MOUSE
189.703 135.964 395.609 243.793 137.559 331.802 135.646 177.984 175.305 345.87 289.092 265.958 200.214 179.317 270.864 199.22 208.964 221.499 156.394 73.1172 210.725 221.873 130.587 208.545 174.103 96.5189 161.224 114.5 114.309 288.33 208.008 239.022 171.762 187.844 240.011 156.192 275.871 183.061 38.2923 152.125 250.733 286.512 347.729 329.562 291.822 139.231 110.679 261.311 254.573 204.202 249.195 207.079 276.977 392.791 199.8 183.875 303.674 236.698 163.016 95.8592 149.339 259.436
209.488 74.0663 286.46 191.881 136.626 228.432 91.5191 231.862 164.843 370.323 149.448 100.033 193.345 82.8269 335.685 398.694 558.112 176.32 188.763 876.534 153.394 136.186 143.217 208.781 285.133 99.9614 161.874 108.143 379.787 402.335 275.77 109.831 218.482 148.254 135.111 258.486 494.073 351.068 670.482 168.664 259.96 318.17 328.135 334.847 278.761 181.439 355.678 374.952 210.288 221.242 360.879 344.685 256.032 230.27 236.426 236.876 374.181 162.382 152.695 98.5686 737.088 383.837
190.747 81.2716 515.542 163.311 145.983 229.958 121.891 141.485 147.315 317.124 228.033 154.925 151.279 123.982 219.539 273.636 463.838 219.112 190.598 684.034 155.663 365.536 140.972 175.406 256.223 166.011 176.879 100.694 580.169 249.246 168.095 154.494 147.463 109.696 215.532 253.005 679.891 305.209 540.863 135.909 199.787 193.043 405.902 861.666 239.751 216.844 557.542 299.332 183.132 327.044 190.981 316.18 224.299 466.841 189.328 262.406 198.649 126.844 188.016 84.5228 405.362 365.431
1.49 1.46 1.45 1.43 1.43 1.43 1.42 1.42 1.41 1.41 1.38 1.35 1.35 1.35 1.34 1.34 1.33 1.32 1.32 1.32 1.31 1.30 1.30 1.29 1.29 1.29 1.29 1.28 1.28 1.28 1.28 1.28 1.27 1.27 1.27 1.27 1.27 1.26 1.26 1.25 1.25 1.25 1.25 1.24 1.23 1.23 1.23 1.22 1.22 1.22 1.22 1.22 1.21 1.21 1.21 1.21 1.21 1.21 1.20 1.19 1.19 1.19
1.46 0.76 1.39 0.84 0.98 1.16 0.91 1.24 1.03 1.06 1.12 0.54 1.17 0.62 1.23 1.77 3.77 1.00 1.33 12.83 0.91 1.44 1.19 1.01 1.71 1.33 1.38 0.95 4.18 1.28 1.23 0.62 1.25 0.75 0.85 1.83 2.48 1.92 16.30 1.18 0.96 1.03 1.15 1.92 1.38 1.52 4.39 1.41 0.88 1.29 1.06 1.83 1.04 1.14 1.02 1.36 1.01 0.71 1.14 0.96 3.74 1.63
ACCEPTED MANUSCRIPT
151.381 203.168 129.382 262.731 112.409 125.723 155.051 143.195 98.1145 229.997 146.686 148.481 242.999 173.178 123.929 207.764 99.9785 150.748 162.875 237.877 185.715 221.995 151.442 72.9858 181.802 228.598 201.158 177.531 173.715 229.683 230.39 181.777 114.206 161.99 290.894 250.541 260.811 240.051 261.766 169.68 201.085 155.422 350.201 149.441 191.573 109.203 244.988 216.241 171.753 248.252 138.413 114.258 211.888 148.48 268.083 130.307 418.759 185.179 149.505 162.709 290.869 227.418
208.109 247.505 183.053 332.236 171.754 155.63 225.846 172.274 146.248 370.505 161.761 184.636 288.235 201.463 137.475 208.992 146.453 206.897 175.444 261.137 225.797 219.617 163.395 98.1832 245.502 216.038 235.398 189.325 227.831 237.725 323.598 220.839 176.257 204.627 276.186 201.878 290.487 288.261 291.114 202.031 218.727 173.676 419.863 188.52 285.542 151.033 329.418 278.648 226.204 284.888 176.523 169.462 258.708 178.541 316.198 194.425 504.262 240.125 198.301 186.836 327.702 256.934
RI PT
171.375 215.597 142.084 303.33 133.415 132.135 177.903 130.938 103.624 298.194 123.634 174.626 260.326 150.416 128.874 199.705 108.595 163.565 146.472 216.1 184.083 179.542 144.89 72.9358 188.821 181.495 237.794 170.769 191.956 161.62 284.69 201.41 140.571 189.391 284.82 232.807 224.875 277.567 230.283 161.37 206.406 138.238 365.785 159.593 227.768 121.078 308.422 277.301 187.889 266.774 144.117 148.615 293.159 151.081 274.73 184.16 410.204 196.594 179.353 161.653 310.61 218.281
SC
4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
M AN U
TE D
Arhgap35 Trmt112 Wdr11 Ube3c Pet112 Golph3 Kpna6 Postn Sec24d Ppif Mrpl2 Tigar Ctnnbl1 Cxx1b Rars2 Tnpo2 Sh3bgrl3 Gulp1 Tbc1d9b Sptlc1 Immt Cops7a Drg2 Ralgapa2 Ppp1r12a Tbc1d15 Pbdc1 Ece1 Cuta Ttll12 Wapal Rrp1 Ubap1 Becn1 Sord Kiaa1033 Mterfd3 Nxf1 Mcmbp Copz2 Parl Raph1 Sh2b2 Chid1 Akr1b10 Rab5b Top3b Pi4ka Agpat3 Chchd1
PLCD1_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 RBM14_MOUSE RNA-binding protein 14 DIDO1_MOUSE Death-inducer obliterator 1 ERG7_MOUSE Lanosterol synthase TRI56_MOUSE E3 ubiquitin-protein ligase TRIM56 E41L5_MOUSE Band 4.1-like protein 5 Q8BH40_MOUSE Syntaxin 7 LRIG1_MOUSE Leucine-rich repeats and immunoglobulin-like domains protein 1 TBC23_MOUSE TBC1 domain family member 23 SNF8_MOUSE Vacuolar-sorting protein SNF8 RRS1_MOUSE Ribosome biogenesis regulatory protein homolog CT024_MOUSE Uncharacterized protein C20orf24 homolog RHG35_MOUSE Rho GTPase-activating protein 35 TR112_MOUSE tRNA methyltransferase 112 homolog WDR11_MOUSE WD repeat-containing protein 11 UBE3C_MOUSE Ubiquitin-protein ligase E3C GATB_MOUSE Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial GOLP3_MOUSE Golgi phosphoprotein 3 IMA7_MOUSE Importin subunit alpha-7 POSTN_MOUSE Periostin Q6NXL1_MOUSE Protein Sec24d PPIF_MOUSE Peptidyl-prolyl cis-trans isomerase F, mitochondrial RM02_MOUSE 39S ribosomal protein L2, mitochondrial TIGAR_MOUSE Fructose-2,6-bisphosphatase TIGAR CTBL1_MOUSE Beta-catenin-like protein 1 Q9D1F0_MOUSE CAAX box 1 homolog A (Human) SYRM_MOUSE Probable arginine--tRNA ligase, mitochondrial TNPO2_MOUSE Transportin-2 SH3L3_MOUSE SH3 domain-binding glutamic acid-rich-like protein 3 GULP1_MOUSE PTB domain-containing engulfment adapter protein 1 TBC9B_MOUSE TBC1 domain family member 9B SPTC1_MOUSE Serine palmitoyltransferase 1 IMMT_MOUSE Isoform 2 of Mitochondrial inner membrane protein CSN7A_MOUSE COP9 signalosome complex subunit 7a DRG2_MOUSE Developmentally-regulated GTP-binding protein 2 RGPA2_MOUSE Ral GTPase-activating protein subunit alpha-2 MYPT1_MOUSE Protein phosphatase 1 regulatory subunit 12A TBC15_MOUSE TBC1 domain family member 15 PBDC1_MOUSE Protein PBDC1 ECE1_MOUSE Endothelin-converting enzyme 1 CUTA_MOUSE Protein CutA TTL12_MOUSE Tubulin--tyrosine ligase-like protein 12 WAPL_MOUSE Wings apart-like protein homolog RRP1_MOUSE Ribosomal RNA processing protein 1 homolog A UBAP1_MOUSE Ubiquitin-associated protein 1 BECN1_MOUSE Beclin-1 DHSO_MOUSE Sorbitol dehydrogenase WASH7_MOUSE WASH complex subunit 7 MTER3_MOUSE mTERF domain-containing protein 3, mitochondrial NXF1_MOUSE Nuclear RNA export factor 1 MCMBP_MOUSE Mini-chromosome maintenance complex-binding protein COPZ2_MOUSE Coatomer subunit zeta-2 PARL_MOUSE Presenilins-associated rhomboid-like protein, mitochondrial F2Z3U3_MOUSE Protein Raph1 (Fragment) SH2B2_MOUSE SH2B adapter protein 2 CHID1_MOUSE Chitinase domain-containing protein 1 D3Z494_MOUSE MCG142264, isoform CRA_a RAB5B_MOUSE Ras-related protein Rab-5B TOP3B_MOUSE DNA topoisomerase 3-beta-1 E9Q3L2_MOUSE Protein Pi4ka PLCC_MOUSE 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma CHCH1_MOUSE Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
EP
Plcd1 Rbm14 Dido1 Lss Trim56 Epb41l5 Stx7 Lrig1 Tbc1d23 Snf8 Rrs1
AC C
sp|Q8R3B1|PLCD1_MOUSE sp|Q8C2Q3|RBM14_MOUSE sp|Q8C9B9|DIDO1_MOUSE sp|Q8BLN5|ERG7_MOUSE sp|Q80VI1|TRI56_MOUSE sp|Q8BGS1|E41L5_MOUSE tr|Q8BH40|Q8BH40_MOUSE sp|P70193|LRIG1_MOUSE sp|Q8K0F1|TBC23_MOUSE sp|Q9CZ28|SNF8_MOUSE sp|Q9CYH6|RRS1_MOUSE sp|Q9CQT9|CT024_MOUSE sp|Q91YM2|RHG35_MOUSE sp|Q9DCG9|TR112_MOUSE sp|Q8K1X1|WDR11_MOUSE sp|Q80U95|UBE3C_MOUSE sp|Q99JT1|GATB_MOUSE sp|Q9CRA5|GOLP3_MOUSE sp|O35345|IMA7_MOUSE sp|Q62009|POSTN_MOUSE tr|Q6NXL1|Q6NXL1_MOUSE sp|Q99KR7|PPIF_MOUSE sp|Q9D773|RM02_MOUSE sp|Q8BZA9|TIGAR_MOUSE sp|Q9CWL8|CTBL1_MOUSE tr|Q9D1F0|Q9D1F0_MOUSE sp|Q3U186|SYRM_MOUSE sp|Q99LG2|TNPO2_MOUSE sp|Q91VW3|SH3L3_MOUSE sp|Q8K2A1|GULP1_MOUSE sp|Q5SVR0|TBC9B_MOUSE sp|O35704|SPTC1_MOUSE sp|Q8CAQ8-2|IMMT_MOUSE sp|Q9CZ04|CSN7A_MOUSE sp|Q9QXB9|DRG2_MOUSE sp|A3KGS3|RGPA2_MOUSE sp|Q9DBR7|MYPT1_MOUSE sp|Q9CXF4|TBC15_MOUSE sp|Q9D0B6|PBDC1_MOUSE sp|Q4PZA2|ECE1_MOUSE sp|Q9CQ89|CUTA_MOUSE sp|Q3UDE2|TTL12_MOUSE sp|Q65Z40|WAPL_MOUSE sp|P56183|RRP1_MOUSE sp|Q8BH48|UBAP1_MOUSE sp|O88597|BECN1_MOUSE sp|Q64442|DHSO_MOUSE sp|Q3UMB9|WASH7_MOUSE sp|Q8BKY8|MTER3_MOUSE sp|Q99JX7|NXF1_MOUSE sp|Q8R3C0|MCMBP_MOUSE sp|Q9JHH9|COPZ2_MOUSE sp|Q5XJY4|PARL_MOUSE tr|F2Z3U3|F2Z3U3_MOUSE sp|Q9JID9|SH2B2_MOUSE sp|Q922Q9|CHID1_MOUSE tr|D3Z494|D3Z494_MOUSE sp|P61021|RAB5B_MOUSE sp|Q9Z321|TOP3B_MOUSE tr|E9Q3L2|E9Q3L2_MOUSE sp|Q9D517|PLCC_MOUSE sp|Q9CQA6|CHCH1_MOUSE
172.841 245.621 135.954 331.221 115.429 145.447 162.234 147.229 88.5389 242.888 151.634 189.557 292.946 171.807 153.874 259.144 92.8512 153.684 179.38 256.567 195.61 237.222 173.098 67.446 174.124 247.89 261.01 204.37 185.066 204.094 257.413 210.854 110.006 188.488 366.992 337.595 251.334 288.118 255.899 165.045 233.003 151.355 370.473 152.248 176.367 102.501 278.855 263.58 168.64 279.22 132.508 117.686 292.729 148.312 274.405 147.702 397.594 175.065 159.186 165.247 325.175 226.073
383.377 643.211 126.479 164.016 357.221 150.574 322.667 46.0653 387.659 234.89 107.599 147.72 211.17 123.054 203.915 236.911 138.245 199.543 158.013 83.2981 220.682 153.851 159.956 489.288 218.334 318.35 112.277 266.348 114.035 373.212 246.962 209.098 212.997 236.917 270.614 152.253 257.631 296.413 344.126 141.504 247.873 242.998 446.53 78.9943 142.181 132.181 178.247 305.04 173.123 364.039 139.84 119.674 327.687 263.346 299.305 138.715 406.166 263.494 161.191 256.741 301.62 137.434
296.542 744.505 291.73 141.286 394.478 93.2745 536.419 76.534 244.438 293.124 172.396 123.291 254.682 239.511 136.316 180.185 141.316 187.625 146.88 107.753 137.972 338.538 283.843 474.497 119.59 344.471 156.936 164.751 250.339 651.645 263.959 203.21 240.48 223.593 228.456 190.886 330.684 221.371 540.522 129.237 538.483 215.573 748.882 57.0691 366.05 118.054 362.465 159.28 282.304 321.828 126.265 101.925 215.545 384.557 372.638 106.457 487.269 178.563 148.615 166.377 270.112 261.148
1.18 1.18 1.18 1.17 1.17 1.17 1.17 1.17 1.16 1.16 1.16 1.16 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.14 1.14 1.14 1.14 1.14 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.12 1.12 1.12 1.12 1.12 1.11 1.11 1.11 1.11 1.11 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.08
2.11 3.31 1.54 0.54 3.06 0.95 2.58 0.45 3.13 1.00 1.04 0.84 0.93 1.12 1.35 1.02 1.34 1.23 0.99 0.42 0.97 1.23 1.50 6.60 0.91 1.62 0.61 1.24 1.00 2.62 0.99 1.08 1.78 1.31 0.87 0.71 1.21 1.00 1.80 0.82 1.93 1.56 1.67 0.44 1.21 1.09 0.98 0.94 1.27 1.33 0.94 0.84 1.08 2.16 1.24 0.78 1.08 1.16 0.94 1.30 0.95 0.89
ACCEPTED MANUSCRIPT
151.77 228.258 146.714 228.941 240.454 164.985 162.759 362.494 351.688 110.988 158.19 155.426 192.634 414.121 125.834 153.906 275.882 169.171 114.977 185.392 99.4349 171.199 292.749 229.918 111.495 90.656 77.3015 105.366 248.139 355.905 205.296 147.145 248.827 180.247 335.609 263.944 76.8881 241.688 171.073 193.622 281.455 126.007 26.0341 201.108 192.361 167.324 216.744 257.098 132.819 127.42 462.634 270.736 140.818 142.214 262.509 287.532 174.849 402.185 210.308 148.077 216.66 77.0988
174.752 294.029 169.081 289.859 314.717 219.31 200.217 419.596 396.5 139.015 199.866 170.712 215.324 509.515 171.991 180.617 338.545 219.325 153.745 251.627 121.968 252.534 360.095 253.59 145.711 121.21 95.6621 121.497 311.893 385.12 238.122 157.7 291.462 191.007 512.648 313.654 87.8001 256.116 216.511 275.912 301.28 160.691 37.2715 222.27 191.917 203.61 250.967 321.073 158.768 122.855 362.125 290.939 126.856 145.136 299.037 244.147 154.274 442.58 247.293 168.04 228.361 88.6077
RI PT
153.663 253.969 151.302 257.8 260.394 185.794 172.217 371.134 316.304 116.447 162.67 148.898 185.853 464.993 139.633 162.309 307.457 197.418 142.569 175.66 104.704 223.675 357.674 211.021 117.588 109.22 101.253 100.74 272.153 311.739 221.412 128.434 294.452 175.891 486.996 277.463 75.6764 214.91 210.953 244.354 296.045 151.219 29.514 185.259 201.839 210.786 249.494 314.778 143.687 104.67 374.238 271.85 110.424 144.157 274.701 233.159 130.516 399.16 231.052 178.601 197.974 84.937
SC
4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
M AN U
Map2k4 Gatad2b Ugt1a7c Trim47 Gcdh Fnbp1 Plaa Bsdc1 Pofut1 Rtn4ip1 Ecsit Kif21a Ppp1r14b Mrpl24 Smg1 Rpl34 Stk38 Klhl22 Nupl1 Uqcrh Ccnd2 Cux1 Mbd3 Ifi35 Nudcd3 Eny2 Gtf2e2 Adi1 Coq5 Cpsf2 Ptpn12 Rpa3
TE D
Pde4dip Serpinb9 Ppp1r8 Cpox
CD302_MOUSE CD302 antigen EXTL3_MOUSE Exostosin-like 3 NUB1_MOUSE NEDD8 ultimate buster 1 LGMN_MOUSE Legumain ATG3_MOUSE Ubiquitin-like-conjugating enzyme ATG3 LSM6_MOUSE U6 snRNA-associated Sm-like protein LSm6 CYFP1_MOUSE Cytoplasmic FMR1-interacting protein 1 RM49_MOUSE 39S ribosomal protein L49, mitochondrial MCEE_MOUSE Methylmalonyl-CoA epimerase, mitochondrial UBP16_MOUSE Ubiquitin carboxyl-terminal hydrolase 16 CPSF5_MOUSE Cleavage and polyadenylation specificity factor subunit 5 NXP20_MOUSE Protein Noxp20 PUM2_MOUSE Isoform 2 of Pumilio homolog 2 K0020_MOUSE Pumilio domain-containing protein KIAA0020 GOLI4_MOUSE Golgi integral membrane protein 4 EMD_MOUSE Emerin EI2BA_MOUSE Translation initiation factor eIF-2B subunit alpha RL39_MOUSE 60S ribosomal protein L39 TTC38_MOUSE Tetratricopeptide repeat protein 38 A2MP_MOUSE Alpha-2-macroglobulin-P COQ3_MOUSE Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial KDM1A_MOUSE Lysine-specific histone demethylase 1A CC50A_MOUSE Cell cycle control protein 50A RRP7A_MOUSE Ribosomal RNA-processing protein 7 homolog A CE051_MOUSE UPF0600 protein C5orf51 homolog MYOME_MOUSE Myomegalin O08797_MOUSE Protein Serpinb9 PP1R8_MOUSE Nuclear inhibitor of protein phosphatase 1 HEM6_MOUSE Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial CO040_MOUSE UPF0235 protein C15orf40 homolog MP2K4_MOUSE Dual specificity mitogen-activated protein kinase kinase 4 P66B_MOUSE Transcriptional repressor p66-beta UD17C_MOUSE UDP-glucuronosyltransferase 1-7C TRI47_MOUSE Isoform 2 of Tripartite motif-containing protein 47 GCDH_MOUSE Glutaryl-CoA dehydrogenase, mitochondrial FNBP1_MOUSE Formin-binding protein 1 PLAP_MOUSE Phospholipase A-2-activating protein BSDC1_MOUSE BSD domain-containing protein 1 OFUT1_MOUSE GDP-fucose protein O-fucosyltransferase 1 RT4I1_MOUSE Reticulon-4-interacting protein 1, mitochondrial ECSIT_MOUSE Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial KI21A_MOUSE Kinesin-like protein KIF21A PP14B_MOUSE Protein phosphatase 1 regulatory subunit 14B RM24_MOUSE 39S ribosomal protein L24, mitochondrial SMG1_MOUSE Serine/threonine-protein kinase SMG1 RL34_MOUSE 60S ribosomal protein L34 STK38_MOUSE Serine/threonine-protein kinase 38 KLH22_MOUSE Kelch-like protein 22 NUPL1_MOUSE Nucleoporin p58/p45 QCR6_MOUSE Cytochrome b-c1 complex subunit 6, mitochondrial CCND2_MOUSE G1/S-specific cyclin-D2 CUX1_MOUSE Homeobox protein cut-like 1 MBD3_MOUSE Methyl-CpG-binding domain protein 3 IN35_MOUSE Interferon-induced 35 kDa protein homolog NUDC3_MOUSE NudC domain-containing protein 3 ENY2_MOUSE Transcription and mRNA export factor ENY2 T2EB_MOUSE General transcription factor IIE subunit 2 MTND_MOUSE 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase COQ5_MOUSE 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial CPSF2_MOUSE Cleavage and polyadenylation specificity factor subunit 2 PTN12_MOUSE Tyrosine-protein phosphatase non-receptor type 12 RFA3_MOUSE Replication protein A 14 kDa subunit
EP
Cd302 Extl3 Nub1 Lgmn Atg3 Lsm6 Cyfip1 Mrpl49 Mcee Usp16 Nudt21 Fam114a1 Pum2 Kiaa0020 Golim4 Emd Eif2b1 Rpl39 Ttc38 A2mp Coq3 Kdm1a Tmem30a Rrp7a
AC C
sp|Q9DCG2|CD302_MOUSE sp|Q9WVL6|EXTL3_MOUSE sp|P54729|NUB1_MOUSE sp|O89017|LGMN_MOUSE sp|Q9CPX6|ATG3_MOUSE sp|P62313|LSM6_MOUSE sp|Q7TMB8|CYFP1_MOUSE sp|Q9CQ40|RM49_MOUSE sp|Q9D1I5|MCEE_MOUSE sp|Q99LG0|UBP16_MOUSE sp|Q9CQF3|CPSF5_MOUSE sp|Q9D281|NXP20_MOUSE sp|Q80U58-2|PUM2_MOUSE sp|Q8BKS9|K0020_MOUSE sp|Q8BXA1|GOLI4_MOUSE sp|O08579|EMD_MOUSE sp|Q99LC8|EI2BA_MOUSE sp|P62892|RL39_MOUSE sp|A3KMP2|TTC38_MOUSE sp|Q6GQT1|A2MP_MOUSE sp|Q8BMS4|COQ3_MOUSE sp|Q6ZQ88|KDM1A_MOUSE sp|Q8VEK0|CC50A_MOUSE sp|Q9D1C9|RRP7A_MOUSE sp|Q8BR90|CE051_MOUSE sp|Q80YT7|MYOME_MOUSE tr|O08797|O08797_MOUSE sp|Q8R3G1|PP1R8_MOUSE sp|P36552|HEM6_MOUSE sp|Q9CRC3|CO040_MOUSE sp|P47809|MP2K4_MOUSE sp|Q8VHR5|P66B_MOUSE sp|Q6ZQM8|UD17C_MOUSE sp|Q8C0E3-2|TRI47_MOUSE sp|Q60759|GCDH_MOUSE sp|Q80TY0|FNBP1_MOUSE sp|P27612|PLAP_MOUSE sp|Q80Y55|BSDC1_MOUSE sp|Q91ZW2|OFUT1_MOUSE sp|Q924D0|RT4I1_MOUSE sp|Q9QZH6|ECSIT_MOUSE sp|Q9QXL2|KI21A_MOUSE sp|Q62084|PP14B_MOUSE sp|Q9CQ06|RM24_MOUSE sp|Q8BKX6|SMG1_MOUSE sp|Q9D1R9|RL34_MOUSE sp|Q91VJ4|STK38_MOUSE sp|Q99JN2|KLH22_MOUSE sp|Q8R332|NUPL1_MOUSE sp|P99028|QCR6_MOUSE sp|P30280|CCND2_MOUSE sp|P53564|CUX1_MOUSE sp|Q9Z2D8|MBD3_MOUSE sp|Q9D8C4|IN35_MOUSE sp|Q8R1N4|NUDC3_MOUSE sp|Q9JIX0|ENY2_MOUSE sp|Q9D902|T2EB_MOUSE sp|Q99JT9|MTND_MOUSE sp|Q9CXI0|COQ5_MOUSE sp|O35218|CPSF2_MOUSE sp|P35831|PTN12_MOUSE sp|Q9CQ71|RFA3_MOUSE
155.57 227.358 152.73 235.389 225.396 158.644 160.504 369.745 321.905 104.51 143.454 154.844 189.262 428.912 110.774 155.816 281.553 169.947 119.611 131.481 94.1966 164.969 327.323 212.266 96.0027 88.7479 91.7535 94.7808 233.638 313.656 207.697 129.963 275.555 179.637 342.775 249.129 70.6316 218.003 178.733 177.002 295.704 125.817 20.0794 175.317 213.1 183.911 226.535 262.828 122.822 113.1 488.308 260.1 128.01 145.297 244.337 281.696 153.921 366.153 197.927 161.218 189.528 74.6159
97.9597 233.745 195.913 56.3237 276.326 194.859 167.135 182.029 61.8255 195.525 168.093 186.083 205.443 406.906 178.556 202.739 316.286 140.547 108.267 142.327 142.939 220.939 316.619 265.057 304.651 263.232 356.525 206.13 336.331 208.886 248.662 155.789 370.348 226.858 420.2 158.603 781.716 217.565 163.809 88.6733 174.64 115.404 387.695 71.2375 288.877 169.652 154.773 253 178.128 92.1044 242.701 297.242 99.3156 88.996 255.715 182.929 111.123 51.8011 105.355 212.476 318.252 104.764
124.181 172.286 153.837 110.784 398.606 228.411 111.067 408.078 415.491 244.155 158.514 151.783 329.252 353.293 177.019 211.9 264.318 284.481 139.033 188.334 490.242 171.149 268.027 322.945 307.051 194.533 299.555 294.51 271.17 501.55 201.727 370.376 191.908 198.799 524.233 390.558 565.631 523.635 163.064 143.751 318.305 168.521 956.153 231.191 214.281 145.696 173.141 269.882 154.853 342.16 392.886 337.345 288.702 227.635 351.964 389.723 201.267 246.42 175.829 240.782 217.599 136.535
1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01
0.73 0.84 1.17 0.34 1.35 1.21 0.83 0.80 0.71 1.93 1.02 1.11 1.41 0.86 1.34 1.31 1.00 1.16 0.96 0.92 3.10 0.99 0.90 1.33 2.67 2.29 3.67 2.43 1.17 1.06 1.06 1.91 1.03 1.20 1.15 1.01 8.83 1.62 0.86 0.53 0.85 1.02 24.19 0.78 1.28 0.83 0.70 0.91 1.20 1.87 0.76 1.17 1.54 1.11 1.13 1.10 1.02 0.37 0.64 1.39 1.29 1.49
ACCEPTED MANUSCRIPT
TE D
172.892 220.441 220.973 198.511 162.184 346.072 310.426 268.971 194.261 165.835 170.098 83.1093 141.201 177.772 162.253 255.146 140.757 186.021 311.224 288.357 448.188 220.178 219.615 230.338 141.07 194.122 220.189 147.366 306.559 335.623 121.065 223.878 151.921 251.626 234.458 198.476 217.316 134.706 199.959 172.576 206.585 201.604 286.482 136.257 286.454 187.501 108.68 221.079 171.211 170.576 237.133 234.953 260.139 173.033 163.744 391.028 180.536 102.533 160.516 201.787 254.181 134.08
153.556 232.453 212.437 224.595 154.867 315.913 320.154 296.584 231.774 175.289 157.63 85.2883 159.848 196.022 197.339 284.597 171.46 195.152 300.17 256.49 397.512 228.896 213.168 233.904 176.418 199.701 240.85 158.974 327.573 372.974 138.648 236.557 169.949 219.074 243.839 261.702 220.261 161.129 242.15 162.472 178.653 184.162 293.918 140.494 304.015 213.309 125.555 255.091 164.355 172.945 274.09 234.445 293.483 189.514 180.972 359.045 200.83 101.202 159.813 196.727 218.66 124.826
RI PT
159.314 207.362 226.072 231.502 186.392 253.849 293.167 311.394 246.737 149.227 154.98 83.9381 160.063 192.863 212.212 281.875 152.414 178.202 271.826 254.48 339.401 253.937 179.852 284.03 174.204 216.671 261.581 171.103 314.348 338.675 133.361 218.567 150.417 242.688 229.192 290.467 198.962 159.279 240.823 161.712 198.159 186.669 274.533 142.378 341.618 204.64 121.149 262.322 147.52 155.477 299.666 273.401 292.781 210.687 207.079 367.077 187.781 103.166 163.199 201.888 212.36 110.412
SC
4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
M AN U
TPC6B_MOUSE Trafficking protein particle complex subunit 6B NOP16_MOUSE Nucleolar protein 16 VPS11_MOUSE Vacuolar protein sorting-associated protein 11 homolog OXND1_MOUSE Oxidoreductase NAD-binding domain-containing protein 1 SPCS2_MOUSE Signal peptidase complex subunit 2 TXD17_MOUSE Thioredoxin domain-containing protein 17 ISY1_MOUSE Pre-mRNA-splicing factor ISY1 homolog INT4_MOUSE Integrator complex subunit 4 RAD21_MOUSE Double-strand-break repair protein rad21 homolog LAP2_MOUSE Protein LAP2 E9Q6Q4_MOUSE Protein Rap1gds1 PSMD5_MOUSE 26S proteasome non-ATPase regulatory subunit 5 IKIP_MOUSE Isoform 2 of Inhibitor of nuclear factor kappa-B kinase-interacting protein CC174_MOUSE Coiled-coil domain-containing protein 174 SCRB2_MOUSE Lysosome membrane protein 2 DIAC_MOUSE Di-N-acetylchitobiase CAPZB_MOUSE Isoform 2 of F-actin-capping protein subunit beta WIBG_MOUSE Partner of Y14 and mago CDK5_MOUSE Cyclin-dependent kinase 5 HTSF1_MOUSE HIV Tat-specific factor 1 homolog A2A5R8_MOUSE Double-stranded RNA-binding protein Staufen homolog 1 F7AC41_MOUSE Protein Pus7 (Fragment) UBL4A_MOUSE Ubiquitin-like protein 4A ANGL4_MOUSE Angiopoietin-related protein 4 GLYR1_MOUSE Putative oxidoreductase GLYR1 HACD3_MOUSE Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3 PPAL_MOUSE Lysosomal acid phosphatase DCTN3_MOUSE Dynactin subunit 3 CDK12_MOUSE Cyclin-dependent kinase 12 EDF1_MOUSE Endothelial differentiation-related factor 1 CJ118_MOUSE Uncharacterized protein C10orf118 homolog IFT20_MOUSE Intraflagellar transport protein 20 homolog PACN3_MOUSE Protein kinase C and casein kinase II substrate protein 3 COG3_MOUSE Conserved oligomeric Golgi complex subunit 3 AKAP8_MOUSE A-kinase anchor protein 8 HEXA_MOUSE Beta-hexosaminidase subunit alpha ROA0_MOUSE Heterogeneous nuclear ribonucleoprotein A0 DBLOH_MOUSE Diablo homolog, mitochondrial DNPEP_MOUSE Aspartyl aminopeptidase DSCR3_MOUSE Down syndrome critical region protein 3 homolog SC11A_MOUSE Signal peptidase complex catalytic subunit SEC11A UB2V2_MOUSE Ubiquitin-conjugating enzyme E2 variant 2 TM1L2_MOUSE TOM1-like protein 2 AASD1_MOUSE Alanyl-tRNA editing protein Aarsd1 STK39_MOUSE STE20/SPS1-related proline-alanine-rich protein kinase CTCF_MOUSE Transcriptional repressor CTCF TB10A_MOUSE TBC1 domain family member 10A VTA1_MOUSE Vacuolar protein sorting-associated protein VTA1 homolog P33MX_MOUSE Putative monooxygenase p33MONOX GLRX5_MOUSE Glutaredoxin-related protein 5, mitochondrial PTGR1_MOUSE Prostaglandin reductase 1 CDK4_MOUSE Cyclin-dependent kinase 4 STRN_MOUSE Striatin KT3K_MOUSE Ketosamine-3-kinase RRAS2_MOUSE Ras-related protein R-Ras2 UB2R1_MOUSE Ubiquitin-conjugating enzyme E2 R1 Q8K094_MOUSE Poliovirus receptor I2BP2_MOUSE Interferon regulatory factor 2-binding protein 2 UBL7_MOUSE Ubiquitin-like protein 7 FGFR1_MOUSE Fibroblast growth factor receptor 1 SNUT1_MOUSE U4/U6.U5 tri-snRNP-associated protein 1 CHMP5_MOUSE Charged multivesicular body protein 5
EP
Trappc6b Nop16 Vps11 Oxnad1 Spcs2 Txndc17 Isy1 Ints4 Rad21 Erbb2ip Rap1gds1 Psmd5 Ikbip Ccdc174 Scarb2 Ctbs Capzb Wibg Cdk5 Htatsf1 Stau1 Pus7 Ubl4a Angptl4 Glyr1 ptplad1 Acp2 Dctn3 Cdk12 Edf1 Otg1 Ift20 Pacsin3 Cog3 Akap8 Hexa Hnrnpa0 Diablo Dnpep Dscr3 Sec11a Ube2v2 Tom1l2 Aarsd1 Stk39 Ctcf Tbc1d10a Vta1 P33monox Glrx5 Ptgr1 Cdk4 Strn Fn3krp Rras2 Cdc34 Pvr Irf2bp2 Ubl7 Fgfr1 Sart1 Chmp5
AC C
sp|Q9D289|TPC6B_MOUSE sp|Q9CPT5|NOP16_MOUSE sp|Q91W86|VPS11_MOUSE sp|Q8VE38|OXND1_MOUSE sp|Q9CYN2|SPCS2_MOUSE sp|Q9CQM5|TXD17_MOUSE sp|Q69ZQ2|ISY1_MOUSE sp|Q8CIM8|INT4_MOUSE sp|Q61550|RAD21_MOUSE sp|Q80TH2|LAP2_MOUSE tr|E9Q6Q4|E9Q6Q4_MOUSE sp|Q8BJY1|PSMD5_MOUSE sp|Q9DBZ1-2|IKIP_MOUSE sp|Q3U155|CC174_MOUSE sp|O35114|SCRB2_MOUSE sp|Q8R242|DIAC_MOUSE sp|P47757-2|CAPZB_MOUSE sp|Q8CHP5|WIBG_MOUSE sp|P49615|CDK5_MOUSE sp|Q8BGC0|HTSF1_MOUSE tr|A2A5R8|A2A5R8_MOUSE tr|F7AC41|F7AC41_MOUSE sp|P21126|UBL4A_MOUSE sp|Q9Z1P8|ANGL4_MOUSE sp|Q922P9|GLYR1_MOUSE sp|Q8K2C9|HACD3_MOUSE sp|P24638|PPAL_MOUSE sp|Q9Z0Y1|DCTN3_MOUSE sp|Q14AX6|CDK12_MOUSE sp|Q9JMG1|EDF1_MOUSE sp|Q8C9S4|CJ118_MOUSE sp|Q61025|IFT20_MOUSE sp|Q99JB8|PACN3_MOUSE sp|Q8CI04|COG3_MOUSE sp|Q9DBR0|AKAP8_MOUSE sp|P29416|HEXA_MOUSE sp|Q9CX86|ROA0_MOUSE sp|Q9JIQ3|DBLOH_MOUSE sp|Q9Z2W0|DNPEP_MOUSE sp|O35075|DSCR3_MOUSE sp|Q9R0P6|SC11A_MOUSE sp|Q9D2M8|UB2V2_MOUSE sp|Q5SRX1|TM1L2_MOUSE sp|Q3THG9|AASD1_MOUSE sp|Q9Z1W9|STK39_MOUSE sp|Q61164|CTCF_MOUSE sp|P58802|TB10A_MOUSE sp|Q9CR26|VTA1_MOUSE sp|Q9DBN4|P33MX_MOUSE sp|Q80Y14|GLRX5_MOUSE sp|Q91YR9|PTGR1_MOUSE sp|P30285|CDK4_MOUSE sp|O55106|STRN_MOUSE sp|Q8K274|KT3K_MOUSE sp|P62071|RRAS2_MOUSE sp|Q8CFI2|UB2R1_MOUSE tr|Q8K094|Q8K094_MOUSE sp|E9Q1P8|I2BP2_MOUSE sp|Q91W67|UBL7_MOUSE sp|P16092|FGFR1_MOUSE sp|Q9Z315|SNUT1_MOUSE sp|Q9D7S9|CHMP5_MOUSE
180.058 196.539 234.876 204.775 191.834 279.866 278.98 279.107 205.287 136.844 163.726 79.4198 136.273 167.948 170.37 242.431 115.826 161.715 269.077 271.633 368.697 230.905 173.923 264.317 128.685 197.753 225.227 148.933 272.18 276.322 106.041 187.443 119.685 254.346 200.071 204.995 176.604 118.662 176.713 154.83 205.015 183.642 237.037 123.007 288.825 156.168 90.9197 199.929 135.501 133.684 230.396 243.201 223.084 168.693 164.58 346.667 141.615 90.0284 140.743 177.92 213.78 101.242
212.835 177.193 237.761 158.031 161.038 382.783 269.411 231.879 272.031 198.265 302.933 424.876 173.472 150.931 194.063 247.693 153.218 198.358 372.648 262.455 248.651 208.056 183.798 190.892 282.252 251.118 203.288 240.902 307.948 194.07 74.281 107.97 119.839 293.943 229.453 151.941 142.941 131.98 176.418 156.188 236.186 228.605 124.232 228.421 148.947 133.987 183.5 236.634 78.4978 169.416 283.001 198.626 202.073 164.254 270.135 282.793 306.957 96.908 119.585 100.373 132.05 170.008
169.853 339.355 205.483 282.965 121.598 875.682 519.824 247.627 486.692 332.936 236.791 280.668 94.7951 309.959 67.1277 349.497 149.553 264.122 287.498 631.262 872.144 201.357 338.29 439.911 360.841 212.966 133.238 263.269 436.322 389.021 127.796 257.189 216.661 242.908 397.832 77.2604 319.918 93.3738 198.281 100.927 141.935 349.923 178.279 415.032 123.138 158.018 317.036 217.245 185.348 535.604 277.639 208.903 360.514 240.26 219.422 726.572 185.291 271.535 247.366 161.94 190.582 434.627
1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.92
1.15 1.21 0.99 1.03 0.81 2.10 1.31 0.83 1.72 1.69 1.66 4.22 0.89 1.24 0.70 1.11 1.03 1.27 1.13 1.65 1.42 0.86 1.31 1.23 2.04 1.13 0.70 1.58 1.20 0.86 0.79 0.83 1.11 1.09 1.35 0.47 1.11 0.77 0.85 0.77 0.93 1.49 0.54 2.31 0.43 0.74 2.18 0.94 0.83 2.16 1.04 0.80 1.02 1.05 1.32 1.33 1.34 1.79 1.13 0.65 0.69 2.47
ACCEPTED MANUSCRIPT
129.402 265.137 190.5 172.608 169.115 151.174 133.721 263.185 288.702 224.024 367.866 300.429 154.334 153.647 305.431 255.552 249.603 392.672 107.886 225.426 146.006 139.379 221.818 124.527 250.11 302.238 213.839 193.827 294.545 182.612 144.263 198.002 338.87 206.71 161.875 248.339 292.44 313.094 181.391 282.324 263.948 234.639 216.933 241.143 266.213 715.261 49.5146 68.531 223.162 62.7924 59.7059 64.955 98.5943 39.9502 117.716 107.582 145.958 106.244 144.578 94.0254 105.657 78.8644
123.576 252.925 163.217 127.844 169.607 193.506 130.203 304.26 277.372 237.643 349.42 275.23 136.783 89.319 254.411 230.36 109.012 342.971 93.5036 216.829 119.719 140.006 206.585 125.533 206.9 290.909 155.568 185.151 249.701 179.791 130.495 159.008 255.938 179.9 128.924 240.184 204.995 229.081 156.106 188.848 217.405 158.747 164.033 135.533 153.162 188.728 95.2451 148.273 183.414 129.726 158.983 148.733 181.377 108.108 197.545 193.465 233.41 169.617 235.511 198.079 213.851 161.466
RI PT
103.031 328.697 161.576 131.31 196.836 208.313 137.014 346.466 265.66 273.486 322.453 310.448 151.073 101.344 322.009 219.114 215.722 390.861 90.6121 236.759 167.686 161.119 242.614 146.678 274.713 302.933 242.452 204.684 278.7 203.894 156.477 160.172 338.769 228.459 134.005 292.821 243.314 291.101 239.213 277.134 285.542 212.463 259.852 264.939 300.395 60.4136 20.1857 65.2002 104.638 61.8876 78.5067 72.3071 131.781 62.6984 64.5111 81.7135 163.514 98.9742 113.348 119.436 114.417 90.9365
SC
4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
TE D
SNAG_MOUSE Gamma-soluble NSF attachment protein GET4_MOUSE Golgi to ER traffic protein 4 homolog SPT4A_MOUSE Transcription elongation factor SPT4-A MA7D1_MOUSE MAP7 domain-containing protein 1 Z385A_MOUSE Zinc finger protein 385A PSDE_MOUSE 26S proteasome non-ATPase regulatory subunit 14 CPSF6_MOUSE Cleavage and polyadenylation specificity factor subunit 6 TWF2_MOUSE Twinfilin-2 PSMD9_MOUSE 26S proteasome non-ATPase regulatory subunit 9 IF4A3_MOUSE Eukaryotic initiation factor 4A-III ARCH_MOUSE Protein archease NADK_MOUSE NAD kinase SEC13_MOUSE Protein SEC13 homolog SLMO2_MOUSE Protein slowmo homolog 2 NDRG3_MOUSE Protein NDRG3 CNPY3_MOUSE Protein canopy homolog 3 VATL_MOUSE V-type proton ATPase 16 kDa proteolipid subunit YTHD3_MOUSE YTH domain-containing family protein 3 VATG1_MOUSE V-type proton ATPase subunit G 1 MPDZ_MOUSE Multiple PDZ domain protein SEH1_MOUSE Nucleoporin SEH1 CHTOP_MOUSE Chromatin target of PRMT1 protein GLPK_MOUSE Glycerol kinase SRSF2_MOUSE Serine/arginine-rich splicing factor 2 CREG1_MOUSE Protein CREG1 GRPE2_MOUSE GrpE protein homolog 2, mitochondrial AAKG1_MOUSE 5'-AMP-activated protein kinase subunit gamma-1 BCAR1_MOUSE Breast cancer anti-estrogen resistance protein 1 THYN1_MOUSE Thymocyte nuclear protein 1 ACY1_MOUSE Aminoacylase-1 NCOA1_MOUSE Nuclear receptor coactivator 1 DNJA4_MOUSE DnaJ homolog subfamily A member 4 Q99L20_MOUSE Glutathione S-transferase theta 3 RCOR1_MOUSE REST corepressor 1 RPB4_MOUSE DNA-directed RNA polymerase II subunit RPB4 DJC28_MOUSE DnaJ homolog subfamily C member 28 PPM1F_MOUSE Protein phosphatase 1F IMPCT_MOUSE Protein IMPACT GNPI1_MOUSE Glucosamine-6-phosphate isomerase 1 NRBP_MOUSE Nuclear receptor-binding protein GALNS_MOUSE N-acetylgalactosamine-6-sulfatase NC2A_MOUSE Dr1-associated corepressor HACL1_MOUSE 2-hydroxyacyl-CoA lyase 1 D3YZZ5_MOUSE Protein Tmed7 GFRP_MOUSE GTP cyclohydrolase 1 feedback regulatory protein HMGN2_MOUSE Non-histone chromosomal protein HMG-17 PLP2_MOUSE Proteolipid protein 2 NDRG2_MOUSE Protein NDRG2 DYL1_MOUSE Dynein light chain 1, cytoplasmic RET1_MOUSE Retinol-binding protein 1 MCM4_MOUSE DNA replication licensing factor MCM4 Q9ER67_MOUSE Maged2 protein Q8C6B0_MOUSE MCG20149, isoform CRA_a PCOC1_MOUSE Procollagen C-endopeptidase enhancer 1 H2A1_MOUSE Histone H2A type 1 PT100_MOUSE Protein PET100 homolog, mitochondrial ABCD2_MOUSE ATP-binding cassette sub-family D member 2 DDX24_MOUSE ATP-dependent RNA helicase DDX24 RM10_MOUSE 39S ribosomal protein L10, mitochondrial Q91Z40_MOUSE Gbp6 protein DDX51_MOUSE ATP-dependent RNA helicase DDX51 TAP1_MOUSE Antigen peptide transporter 1
EP
Napg Get4 Supt4h1a Map7d1 Znf385a Psmd14 Cpsf6 Twf2 Psmd9 Eif4a3 Zbtb8os Nadk Sec13 Slmo2 Ndrg3 Cnpy3 Atp6v0c Ythdf3 Atp6v1g1 Mpdz Seh1l Chtop Gk Srsf2 Creg1 Grpel2 Prkag1 Bcar1 Thyn1 Acy1 Ncoa1 Dnaja4 Gstt3 Rcor1 Polr2d Dnajc28 Ppm1f Impact Gnpda1 Nrbp1 Galns Drap1 Hacl1 Tmed7 Gchfr Hmgn2 Plp2 Ndrg2 Dynll1 Rbp1 Mcm4 Maged2 Mettl7a1 Pcolce Hist1h2ab Pet100 Abcd2 Ddx24 Mrpl10 Gbp7 Ddx51 Tap1
AC C
sp|Q9CWZ7|SNAG_MOUSE sp|Q9D1H7|GET4_MOUSE sp|P63271|SPT4A_MOUSE sp|A2AJI0|MA7D1_MOUSE sp|Q8VD12|Z385A_MOUSE sp|O35593|PSDE_MOUSE sp|Q6NVF9|CPSF6_MOUSE sp|Q9Z0P5|TWF2_MOUSE sp|Q9CR00|PSMD9_MOUSE sp|Q91VC3|IF4A3_MOUSE sp|Q505B7|ARCH_MOUSE sp|P58058|NADK_MOUSE sp|Q9D1M0|SEC13_MOUSE sp|Q9CYY7|SLMO2_MOUSE sp|Q9QYF9|NDRG3_MOUSE sp|Q9DAU1|CNPY3_MOUSE sp|P63082|VATL_MOUSE sp|Q8BYK6|YTHD3_MOUSE sp|Q9CR51|VATG1_MOUSE sp|Q8VBX6|MPDZ_MOUSE sp|Q8R2U0|SEH1_MOUSE sp|Q9CY57|CHTOP_MOUSE sp|Q64516|GLPK_MOUSE sp|Q62093|SRSF2_MOUSE sp|O88668|CREG1_MOUSE sp|O88396|GRPE2_MOUSE sp|O54950|AAKG1_MOUSE sp|Q61140|BCAR1_MOUSE sp|Q91YJ3|THYN1_MOUSE sp|Q99JW2|ACY1_MOUSE sp|P70365|NCOA1_MOUSE sp|Q9JMC3|DNJA4_MOUSE tr|Q99L20|Q99L20_MOUSE sp|Q8CFE3|RCOR1_MOUSE sp|Q9D7M8|RPB4_MOUSE sp|Q8VCE1|DJC28_MOUSE sp|Q8CGA0|PPM1F_MOUSE sp|O55091|IMPCT_MOUSE sp|O88958|GNPI1_MOUSE sp|Q99J45|NRBP_MOUSE sp|Q571E4|GALNS_MOUSE sp|Q9D6N5|NC2A_MOUSE sp|Q9QXE0|HACL1_MOUSE tr|D3YZZ5|D3YZZ5_MOUSE sp|P99025|GFRP_MOUSE sp|P09602|HMGN2_MOUSE sp|Q9R1Q7|PLP2_MOUSE sp|Q9QYG0|NDRG2_MOUSE sp|P63168|DYL1_MOUSE sp|Q00915|RET1_MOUSE sp|P49717|MCM4_MOUSE tr|Q9ER67|Q9ER67_MOUSE tr|Q8C6B0|Q8C6B0_MOUSE sp|Q61398|PCOC1_MOUSE sp|P22752|H2A1_MOUSE sp|P0DJE0|PT100_MOUSE sp|Q61285|ABCD2_MOUSE sp|Q9ESV0|DDX24_MOUSE sp|Q3TBW2|RM10_MOUSE tr|Q91Z40|Q91Z40_MOUSE sp|Q6P9R1|DDX51_MOUSE sp|P21958|TAP1_MOUSE
91.2873 293.755 159.415 149.154 163.267 133.171 115.738 248.784 225.196 211.472 271.071 272.726 136.504 137.25 297.822 185.893 298.267 336.174 77.7386 179.716 149.234 116.845 188.87 104.529 236.987 219.877 227.267 147.217 227.823 142.028 116.267 133.21 294.866 170.496 104.602 182.211 208.697 237.32 167.796 234.708 177.12 160.65 172.186 200.955 106.681 72.7697 194.51 139.362 487.115 122.013 119.729 127.211 250.499 81.1944 124.837 140.132 273.303 162.871 181.503 143.548 138.045 105.757
167.085 302.751 137.254 80.2872 133.366 179.102 249.751 194.958 215.321 190.271 252.311 317.727 253.391 91.073 281.489 171.901 229.712 269.475 71.3322 171.395 194.851 94.7626 332.256 105.079 179.68 217.909 330.7 173.072 416.501 132.653 107.823 237.322 626.902 159.435 201.114 104.037 177.507 144.085 198.328 273.012 210.31 140.029 155.458 190.902 177.41 102.828 107.66 254.457 357.153 75.8982 136.244 60.9997 119.047 20.3761 223.81 93.7527 75.9321 110.33 99.6601 78.5516 169.282 64.0553
338.497 213.195 264.427 169.491 224.656 179.95 303.791 273.624 385.555 168.945 435.338 383.114 396.475 205.171 387.461 318.722 260.649 374.998 183.928 325.887 189.408 169.106 262.111 194.761 264.152 356.624 240.036 187.616 802.946 172.804 291.414 223.198 1117.06 245.317 145.189 248.174 175.472 312.053 127.137 212.542 221.648 223.586 172.928 148.982 125.661 183.917 28.9813 332.897 135.168 85.0153 75.8306 37.9465 101.325 27.2592 97.1813 87.7364 86.4935 303.108 126.239 48.467 110.808 48.75
0.92 0.92 0.92 0.91 0.91 0.91 0.91 0.91 0.91 0.90 0.90 0.90 0.89 0.89 0.88 0.88 0.88 0.87 0.86 0.86 0.86 0.85 0.85 0.85 0.85 0.84 0.84 0.83 0.83 0.83 0.82 0.82 0.81 0.81 0.79 0.78 0.77 0.77 0.77 0.76 0.72 0.71 0.71 0.66 0.46 0.34 4.16 2.15 2.05 2.02 2.02 2.01 1.87 1.84 1.77 1.76 1.64 1.62 1.62 1.60 1.60 1.57
2.18 0.87 1.14 0.82 0.98 1.00 2.04 0.77 1.08 0.72 1.00 1.15 2.13 1.16 1.07 1.03 1.05 0.82 1.29 1.08 1.22 0.88 1.28 1.11 0.85 0.95 1.25 0.91 2.13 0.79 1.33 1.29 2.57 0.93 1.17 0.65 0.66 0.75 0.77 0.87 0.79 0.81 0.69 0.67 0.53 0.37 1.96 4.39 1.50 1.29 1.53 0.72 0.96 0.46 1.76 0.96 0.52 2.01 0.88 0.60 1.27 0.66
ACCEPTED MANUSCRIPT
TE D
117.705 90.1547 128.082 68.5752 179.761 89.7385 136.795 237.247 217.351 122.123 101.409 82.594 97.0459 135.084 114.744 66.8692 101.869 92.2279 85.3703 116.104 27.0063 113.051 197.705 93.5002 22.773 76.0802 103.694 71.6555 66.3823 110.298 83.9154 85.6538 70.9063 285.449 83.6734 170.852 162.749 78.4624 141.013 68.5138 159.115 44.386 101.427 21.5104 118.374 130.055 137.109 161.719 128.33 130.256 185.715 162.325 161.475 129.027 322.107 78.7455 128.038 125.412 129.927 212.198 81.9653 66.3383
157.992 217.56 151.712 112.954 292.29 150.321 338.863 194.621 345.768 246.745 177.142 133.324 170.202 219.023 186.702 187.632 222.835 146.85 159.091 174.861 110.244 237.045 346.402 176.26 39.8587 79.9582 180.385 100.497 98.3788 155.447 124.392 136.637 118.922 451.918 136.615 228.916 242.83 137.862 202.259 112.767 236.86 58.9485 190.099 32.7556 218.318 174.92 179.426 297.148 215.239 189.108 204.558 257.294 258.121 208.33 472.632 132.721 187.609 260.673 178.212 305.982 110.09 135.641
RI PT
98.3032 127.861 101.194 62.891 178.174 101.811 198.521 144.836 220.097 156.552 112.204 90.5249 109.208 145.046 129.623 136.151 163.153 106.47 98.2429 111.584 70.8404 157.844 242.151 114.081 27.7561 57.482 118.091 66.3903 66.1079 107.771 82.3411 96.9382 88.3395 262.504 92.9748 182.212 185.616 96.2012 169.862 68.7105 159.514 37.7973 129.161 21.4282 147.485 120.866 130.759 181.402 148.489 143.767 171.719 193.615 190.697 145.175 323.628 89.9796 136.98 202.331 141.778 250.687 83.4543 101.986
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
ATRX_MOUSE Transcriptional regulator ATRX KS6A5_MOUSE Ribosomal protein S6 kinase alpha-5 UBXN4_MOUSE UBX domain-containing protein 4 INF2_MOUSE Inverted formin-2 EXOC5_MOUSE Exocyst complex component 5 CLP1L_MOUSE Cleft lip and palate transmembrane protein 1-like protein ITB3_MOUSE Integrin beta-3 RTN1_MOUSE Reticulon-1 RARR2_MOUSE Retinoic acid receptor responder protein 2 D3Z7Q2_MOUSE Protein Smim20 SMDC1_MOUSE SAYSvFN domain-containing protein 1 ZZEF1_MOUSE Zinc finger ZZ-type and EF-hand domain-containing protein 1 TRM11_MOUSE tRNA (guanine(10)-N2)-methyltransferase homolog SPP2A_MOUSE Signal peptide peptidase-like 2A ALG2_MOUSE Alpha-1,3/1,6-mannosyltransferase ALG2 DPTOR_MOUSE DEP domain-containing mTOR-interacting protein CCD80_MOUSE Coiled-coil domain-containing protein 80 RRP44_MOUSE Exosome complex exonuclease RRP44 DHX30_MOUSE Putative ATP-dependent RNA helicase DHX30 RRP12_MOUSE RRP12-like protein TXNIP_MOUSE Thioredoxin-interacting protein THEM4_MOUSE Acyl-coenzyme A thioesterase THEM4 DOCK1_MOUSE Dedicator of cytokinesis protein 1 SYMPK_MOUSE Symplekin MYEF2_MOUSE Myelin expression factor 2 OXR1_MOUSE Oxidation resistance protein 1 RTCA_MOUSE RNA 3'-terminal phosphate cyclase RPOM_MOUSE DNA-directed RNA polymerase, mitochondrial GNAS2_MOUSE Guanine nucleotide-binding protein G(s) subunit alpha isoforms short BIG2_MOUSE Brefeldin A-inhibited guanine nucleotide-exchange protein 2 APLP2_MOUSE Amyloid-like protein 2 MVD1_MOUSE Diphosphomevalonate decarboxylase RBM28_MOUSE RNA-binding protein 28 DJC15_MOUSE DnaJ homolog subfamily C member 15 RAB3D_MOUSE Ras-related protein Rab-3D A2ANY6_MOUSE Midasin RAD50_MOUSE DNA repair protein RAD50 NQO2_MOUSE Ribosyldihydronicotinamide dehydrogenase [quinone] YLAT2_MOUSE Y+L amino acid transporter 2 BRD7_MOUSE Bromodomain-containing protein 7 PYRD_MOUSE Dihydroorotate dehydrogenase (quinone), mitochondrial RHOA_MOUSE Transforming protein RhoA GTPB1_MOUSE GTP-binding protein 1 FAF2_MOUSE FAS-associated factor 2 CB39L_MOUSE Calcium-binding protein 39-like E9PYK3_MOUSE Protein Parp4 PARP9_MOUSE Poly [ADP-ribose] polymerase 9 TX1B3_MOUSE Tax1-binding protein 3 E9Q735_MOUSE Protein Ube4a DDX50_MOUSE ATP-dependent RNA helicase DDX50 FLII_MOUSE Protein flightless-1 homolog ITM2B_MOUSE Integral membrane protein 2B CP2F2_MOUSE Cytochrome P450 2F2 E9Q137_MOUSE Protein Tex264 MCUR1_MOUSE Mitochondrial calcium uniporter regulator 1 SPCS_MOUSE O-phosphoseryl-tRNA(Sec) selenium transferase GPC4_MOUSE Glypican-4 ACD11_MOUSE Acyl-CoA dehydrogenase family member 11 LBR_MOUSE Lamin-B receptor ALG5_MOUSE Dolichyl-phosphate beta-glucosyltransferase NU133_MOUSE Nuclear pore complex protein Nup133 NFIB_MOUSE Nuclear factor 1 B-type
EP
Atrx Rps6ka5 Ubxn4 Inf2 Exoc5 Clptm1l Itgb3 Rtn1 Rarres2 Smim20 Saysd1 Zzef1 Trmt11 Sppl2a Alg2 Deptor Ccdc80 Dis3 Dhx30 Rrp12 Txnip Them4 Dock1 Sympk Myef2 Oxr1 RtcA Polrmt Gnas Arfgef2 Aplp2 Mvd Rbm28 Dnajc15 Rab3d Mdn1 Rad50 Nqo2 Slc7a6 Brd7 Dhodh Rhoa Gtpbp1 Faf2 Cab39l Parp4 Parp9 Tax1bp3 Ube4a Ddx50 Flii Itm2b Cyp2f2 Tex264 Mcur1 Sepsecs Gpc4 Acad11 Lbr Alg5 Nup133 Nfib
AC C
sp|Q61687|ATRX_MOUSE sp|Q8C050|KS6A5_MOUSE sp|Q8VCH8|UBXN4_MOUSE sp|Q0GNC1|INF2_MOUSE sp|Q3TPX4|EXOC5_MOUSE sp|Q8BXA5|CLP1L_MOUSE sp|O54890|ITB3_MOUSE sp|Q8K0T0|RTN1_MOUSE sp|Q9DD06|RARR2_MOUSE tr|D3Z7Q2|D3Z7Q2_MOUSE sp|Q8K190|SMDC1_MOUSE sp|Q5SSH7|ZZEF1_MOUSE sp|Q9CWH5|TRM11_MOUSE sp|Q9JJF9|SPP2A_MOUSE sp|Q9DBE8|ALG2_MOUSE sp|Q570Y9|DPTOR_MOUSE sp|Q8R2G6|CCD80_MOUSE sp|Q9CSH3|RRP44_MOUSE sp|Q99PU8|DHX30_MOUSE sp|Q6P5B0|RRP12_MOUSE sp|Q8BG60|TXNIP_MOUSE sp|Q3UUI3|THEM4_MOUSE sp|Q8BUR4|DOCK1_MOUSE sp|Q80X82|SYMPK_MOUSE sp|Q8C854|MYEF2_MOUSE sp|Q4KMM3|OXR1_MOUSE sp|Q9D7H3|RTCA_MOUSE sp|Q8BKF1|RPOM_MOUSE sp|P63094|GNAS2_MOUSE sp|A2A5R2|BIG2_MOUSE sp|Q06335|APLP2_MOUSE sp|Q99JF5|MVD1_MOUSE sp|Q8CGC6|RBM28_MOUSE sp|Q78YY6|DJC15_MOUSE sp|P35276|RAB3D_MOUSE tr|A2ANY6|A2ANY6_MOUSE sp|P70388|RAD50_MOUSE sp|Q9JI75|NQO2_MOUSE sp|Q8BGK6|YLAT2_MOUSE sp|O88665|BRD7_MOUSE sp|O35435|PYRD_MOUSE sp|Q9QUI0|RHOA_MOUSE sp|O08582|GTPB1_MOUSE sp|Q3TDN2|FAF2_MOUSE sp|Q9DB16|CB39L_MOUSE tr|E9PYK3|E9PYK3_MOUSE sp|Q8CAS9|PARP9_MOUSE sp|Q9DBG9|TX1B3_MOUSE tr|E9Q735|E9Q735_MOUSE sp|Q99MJ9|DDX50_MOUSE sp|Q9JJ28|FLII_MOUSE sp|O89051|ITM2B_MOUSE sp|P33267|CP2F2_MOUSE tr|E9Q137|E9Q137_MOUSE sp|Q9CXD6|MCUR1_MOUSE sp|Q6P6M7|SPCS_MOUSE sp|P51655|GPC4_MOUSE sp|Q80XL6|ACD11_MOUSE sp|Q3U9G9|LBR_MOUSE sp|Q9DB25|ALG5_MOUSE sp|Q8R0G9|NU133_MOUSE sp|P97863|NFIB_MOUSE
178.605 114.413 196.362 82.2913 233.508 130.835 150.819 362.328 287.191 156.08 130.253 115.382 125.767 182.884 162.95 100.236 152.752 134.541 100.589 145.891 27.4323 140.823 266.26 112.47 30.1691 105.12 126.857 90.5256 84.9338 145.505 105.04 115.329 100.719 302.567 105.781 253.811 230.684 99.5116 219.034 71.9107 191.856 51.3308 119.117 24.7627 136.455 157.489 174.219 154.912 147.341 169.729 263.174 207.084 200.283 148.543 367.174 85.6116 155.176 163.089 172.696 291.495 102.838 80.4925
95.7429 82.706 108.242 375.111 250.115 128.795 268.017 220.657 155.698 125.292 85.6321 88.0458 88.1791 152.854 151.585 165.652 59.521 138.715 87.9662 140.734 60.893 192.734 177.659 224.69 380.73 53.9235 140.589 123.777 90.0284 163.067 94.5372 73.9383 125.176 276.931 592.171 367.732 363.375 135.659 437.866 113.901 144.016 406.483 139.513 315.244 199.121 115.316 136.968 177.836 121.096 210.616 276.728 82.2014 84.6523 269.122 344.548 80.8766 200.624 465.964 207.203 212.375 175.221 52.2253
274.985 69.6519 145.333 496.188 217.107 85.1179 148.872 548.299 348.827 170.667 106.949 80.8033 95.2313 193.51 97.8637 216.889 97.5544 83.0507 176.132 86.3874 32.346 129.151 161.194 255.29 494.36 88.0842 126.189 138.138 60.3254 113.998 161.981 54.9807 145.038 318.464 553.876 410.067 271.584 125.507 189.605 168.709 155.429 327.221 117.956 324.593 119.871 120.589 148.998 179.5 122.453 175.955 152.401 137.58 168.592 230.131 263.329 51.8954 254.598 330.334 92.4309 188.016 120.305 90.4166
1.56 1.52 1.52 1.49 1.47 1.47 1.46 1.46 1.45 1.45 1.44 1.44 1.43 1.43 1.43 1.42 1.42 1.42 1.41 1.41 1.41 1.39 1.39 1.39 1.39 1.39 1.39 1.38 1.38 1.38 1.38 1.38 1.38 1.38 1.37 1.37 1.36 1.36 1.36 1.35 1.35 1.34 1.34 1.34 1.33 1.32 1.32 1.32 1.31 1.31 1.31 1.30 1.30 1.30 1.30 1.29 1.29 1.29 1.29 1.29 1.29 1.28
1.72 0.70 1.11 6.63 1.31 1.12 1.24 2.01 1.15 1.06 0.90 0.98 0.89 1.24 1.02 1.88 0.59 1.12 1.44 1.00 0.95 1.19 0.77 2.31 17.32 1.06 1.20 1.90 1.13 1.27 1.54 0.71 1.70 1.09 6.49 2.20 1.82 1.50 2.02 2.06 0.94 8.93 1.12 14.90 1.20 0.94 1.07 1.04 0.88 1.41 1.20 0.62 0.72 1.82 0.94 0.79 1.72 2.43 1.10 0.86 1.79 0.85
ACCEPTED MANUSCRIPT
Mrps2 Rhog Xrcc5 Slc12a4 Gak Wbp2 Pikfyve Znf622 Itgb5 Zc3h18
TE D
145.547 74.8036 219.354 79.8014 162.95 346.543 237.146 125.227 74.2153 176.067 318.927 150.428 120.793 112.017 132.744 162.14 227.799 122.33 144.853 56.7922 181.164 106.877 141.129 159.076 128.156 125.555 114.41 131.931 70.2327 68.735 114.934 146.279 105.545 153.302 99.6795 87.5526 158.918 113.885 179.294 103.937 175.312 146.939 129.791 155.687 122.413 215.287 114.26 965.199 105.104 90.6112 105.11 173.965 174.691 132.265 148.239 164.351 204.548 105.898 115.635 93.6212 129.088 188.196
267.979 93.9399 203.65 110.377 183.604 536.779 259.232 173.23 94.1532 262.085 392.217 222.204 162.145 183.278 208.831 249.383 280.35 201.021 244.714 89.9218 260.74 158.105 208.545 226.777 167.649 198.544 146.494 150.197 103.192 100.006 150.37 178.538 164.002 209.136 86.0657 99.1042 189.642 155.721 170.34 147.85 242.064 174.654 191.351 221.668 155.818 296.838 139.73 923.506 146.708 142.605 123.037 210.819 189.124 189.109 189.986 184.589 284.331 120.548 155.585 135.256 198.383 183.607
RI PT
209.765 57.7226 169.574 76.4631 120.879 386.064 201.983 135.09 69.0489 192.091 276.111 171.272 93.179 142.59 153.098 184.967 231.457 156.692 181.26 72.2082 191.349 120.004 156.342 184.687 131.151 148.931 115.739 108.517 78.7913 79.4645 109.91 152.647 124.15 174.232 67.8537 74.5545 145.61 131.149 177.214 113.153 201.222 143.849 158.235 183.893 118.342 262.573 126.682 538.306 126.576 112.59 95.8324 162.822 185.49 157.169 175.858 165.386 217.948 94.4064 116.643 109.363 164.475 136.668
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
PRP4B_MOUSE Serine/threonine-protein kinase PRP4 homolog BMP2K_MOUSE BMP-2-inducible protein kinase SUMO3_MOUSE Small ubiquitin-related modifier 3 IQEC1_MOUSE IQ motif and SEC7 domain-containing protein 1 ZNFX1_MOUSE NFX1-type zinc finger-containing protein 1 OPLA_MOUSE 5-oxoprolinase GRM1B_MOUSE GRAM domain-containing protein 1B SRGP2_MOUSE SLIT-ROBO Rho GTPase-activating protein 2 CUL7_MOUSE Cullin-7 VIP2_MOUSE Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 EXOC8_MOUSE Exocyst complex component 8 ASAP1_MOUSE Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 LRC57_MOUSE Leucine-rich repeat-containing protein 57 TM165_MOUSE Transmembrane protein 165 ABCB8_MOUSE ATP-binding cassette sub-family B member 8, mitochondrial SAAL1_MOUSE Protein SAAL1 PLXD1_MOUSE Plexin-D1 ZN512_MOUSE Zinc finger protein 512 SYVM_MOUSE Valine--tRNA ligase, mitochondrial TMX1_MOUSE Thioredoxin-related transmembrane protein 1 HS2ST_MOUSE Heparan sulfate 2-O-sulfotransferase 1 ENDD1_MOUSE Endonuclease domain-containing 1 protein ADNP_MOUSE Activity-dependent neuroprotector homeobox protein KDEL1_MOUSE KDEL motif-containing protein 1 MAGT1_MOUSE Magnesium transporter protein 1 ANO6_MOUSE Anoctamin-6 E9PWT1_MOUSE Transformation/transcription domain-associated protein MO4L1_MOUSE Isoform 2 of Mortality factor 4-like protein 1 XYLK_MOUSE Glycosaminoglycan xylosylkinase F6SAC3_MOUSE Glucose-6-phosphate isomerase STX5_MOUSE Syntaxin-5 DCAKD_MOUSE Dephospho-CoA kinase domain-containing protein SPAST_MOUSE Spastin MA1B1_MOUSE Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase RS21_MOUSE 40S ribosomal protein S21 AKP8L_MOUSE A-kinase anchor protein 8-like AAR2_MOUSE Protein AAR2 homolog NNMT_MOUSE Nicotinamide N-methyltransferase PAG15_MOUSE Group XV phospholipase A2 CA2D1_MOUSE Isoform 2C of Voltage-dependent calcium channel subunit alpha-2/delta-1 TPP2_MOUSE Isoform Short of Tripeptidyl-peptidase 2 G3X8R0_MOUSE Receptor accessory protein 5, isoform CRA_a PANK4_MOUSE Pantothenate kinase 4 COX11_MOUSE Cytochrome c oxidase assembly protein COX11, mitochondrial Q6PFF0_MOUSE Protein Scaf4 RAB34_MOUSE Ras-related protein Rab-34 UBR5_MOUSE E3 ubiquitin-protein ligase UBR5 PRRC1_MOUSE Protein PRRC1 MICU1_MOUSE Calcium uptake protein 1, mitochondrial EFR3A_MOUSE Protein EFR3 homolog A SR140_MOUSE U2 snRNP-associated SURP motif-containing protein CX038_MOUSE Uncharacterized protein CXorf38 homolog RT02_MOUSE 28S ribosomal protein S2, mitochondrial RHOG_MOUSE Rho-related GTP-binding protein RhoG XRCC5_MOUSE X-ray repair cross-complementing protein 5 S12A4_MOUSE Solute carrier family 12 member 4 GAK_MOUSE Cyclin-G-associated kinase WBP2_MOUSE WW domain-binding protein 2 FYV1_MOUSE 1-phosphatidylinositol 3-phosphate 5-kinase ZN622_MOUSE Zinc finger protein 622 ITB5_MOUSE Integrin beta-5 ZCH18_MOUSE Zinc finger CCCH domain-containing protein 18
EP
Prpf4b Bmp2k Sumo3 Iqsec1 Znfx1 Oplah Gramd1b Srgap2 Cul7 Ppip5k2 Exoc8 Asap1 Lrrc57 Tmem165 Abcb8 Saal1 Plxnd1 Znf512 Vars2 Tmx1 Hs2st1 Endod1 Adnp Kdelc1 Magt1 Ano6 Trrap Morf4l1 Fam20b Gm1840 Stx5 Dcakd Spast Man1b1 Rps21 Akap8l Aar2 Nnmt Pla2g15 Cacna2d1 Tpp2 Reep5 Pank4 Cox11 Scaf4 Rab34 Ubr5 Prrc1 Micu1 Efr3a U2surp
AC C
sp|Q61136|PRP4B_MOUSE sp|Q91Z96|BMP2K_MOUSE sp|Q9Z172|SUMO3_MOUSE sp|Q8R0S2|IQEC1_MOUSE sp|Q8R151|ZNFX1_MOUSE sp|Q8K010|OPLA_MOUSE sp|Q80TI0|GRM1B_MOUSE sp|Q91Z67|SRGP2_MOUSE sp|Q8VE73|CUL7_MOUSE sp|Q6ZQB6|VIP2_MOUSE sp|Q6PGF7|EXOC8_MOUSE sp|Q9QWY8|ASAP1_MOUSE sp|Q9D1G5|LRC57_MOUSE sp|P52875|TM165_MOUSE sp|Q9CXJ4|ABCB8_MOUSE sp|Q9D2C2|SAAL1_MOUSE sp|Q3UH93|PLXD1_MOUSE sp|Q69Z99|ZN512_MOUSE sp|Q3U2A8|SYVM_MOUSE sp|Q8VBT0|TMX1_MOUSE sp|Q8R3H7|HS2ST_MOUSE sp|Q8C522|ENDD1_MOUSE sp|Q9Z103|ADNP_MOUSE sp|Q9JHP7|KDEL1_MOUSE sp|Q9CQY5|MAGT1_MOUSE sp|Q6P9J9|ANO6_MOUSE tr|E9PWT1|E9PWT1_MOUSE sp|P60762-2|MO4L1_MOUSE sp|Q8VCS3|XYLK_MOUSE tr|F6SAC3|F6SAC3_MOUSE sp|Q8K1E0|STX5_MOUSE sp|Q8BHC4|DCAKD_MOUSE sp|Q9QYY8|SPAST_MOUSE sp|A2AJ15|MA1B1_MOUSE sp|Q9CQR2|RS21_MOUSE sp|Q9R0L7|AKP8L_MOUSE sp|Q9D2V5|AAR2_MOUSE sp|O55239|NNMT_MOUSE sp|Q8VEB4|PAG15_MOUSE sp|O08532-3|CA2D1_MOUSE sp|Q64514-2|TPP2_MOUSE tr|G3X8R0|G3X8R0_MOUSE sp|Q80YV4|PANK4_MOUSE sp|Q6P8I6|COX11_MOUSE tr|Q6PFF0|Q6PFF0_MOUSE sp|Q64008|RAB34_MOUSE sp|Q80TP3|UBR5_MOUSE sp|Q3UPH1|PRRC1_MOUSE sp|Q8VCX5|MICU1_MOUSE sp|Q8BG67|EFR3A_MOUSE sp|Q6NV83|SR140_MOUSE sp|Q8C5K5|CX038_MOUSE sp|Q924T2|RT02_MOUSE sp|P84096|RHOG_MOUSE sp|P27641|XRCC5_MOUSE sp|Q9JIS8|S12A4_MOUSE sp|Q99KY4|GAK_MOUSE sp|P97765|WBP2_MOUSE sp|Q9Z1T6|FYV1_MOUSE sp|Q91VY9|ZN622_MOUSE sp|O70309|ITB5_MOUSE sp|Q0P678|ZCH18_MOUSE
187.835 76.0485 294.829 87.9644 175.311 384.631 291.868 152.443 84.6521 196.687 349.222 177.607 103.395 132.62 145.438 180.408 287.92 144.091 158.273 68.6564 196.858 120.52 156.607 195.061 150.226 137.188 134.445 143.123 78.3274 80.3793 122.422 183.875 113.676 186.085 115.956 96.3092 176.228 138.616 255.59 111.039 206.074 171.083 151.062 181.042 129.295 268.677 145.205 853.929 127.007 96.9054 113.199 184.912 232.687 149.758 189.455 201.439 210.207 113.453 115.733 101.79 144.097 195.223
155.916 92.4452 133.638 276.826 123.079 113.675 127.87 203.421 50.6865 191.391 293.398 224.876 168.728 155.901 104.769 308.77 147.236 109.743 206.214 159.186 309.701 119.462 205.326 119.812 136.488 252.666 125.154 143.006 55.9633 128.091 163.07 204.797 72.3952 234.899 291.231 126.778 179.735 188.785 242.701 161.661 216.872 195.201 186.498 64.8801 121.226 279.635 132.929 644.854 126.661 84.5043 137.369 109.731 92.9812 205.477 119.938 184.854 207.184 64.2856 122.128 176.385 177.695 134.142
154.234 120.92 396.946 607.011 161.881 91.4702 268.012 143.794 65.7444 112.85 264.896 243.856 173.931 128.533 82.3372 184.925 251.063 70.2277 172.683 129.407 132.658 477.448 329.464 133.805 96.4288 129.094 123.381 162.887 52.1558 88.0854 134.737 124.022 103.49 160.147 549.466 202.273 158.504 250.471 258.657 154.275 134.899 249.048 166.538 142.616 174.292 188.128 169.633 806.007 99.9442 63.9983 180.817 184.798 157.589 158.025 128.071 178.538 526.853 59.5686 149.663 129.884 126.96 367.05
1.28 1.28 1.28 1.27 1.26 1.26 1.25 1.25 1.25 1.25 1.25 1.24 1.24 1.24 1.24 1.24 1.24 1.24 1.24 1.23 1.23 1.23 1.23 1.23 1.23 1.22 1.22 1.22 1.22 1.22 1.21 1.21 1.21 1.21 1.21 1.21 1.20 1.20 1.19 1.19 1.19 1.19 1.19 1.19 1.18 1.18 1.18 1.18 1.18 1.18 1.18 1.18 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17
0.87 1.61 1.36 5.66 1.00 0.28 0.90 1.33 0.81 0.83 0.94 1.46 1.60 1.12 0.65 1.42 0.87 0.65 1.16 2.24 1.19 2.63 1.80 0.74 0.90 1.39 1.08 1.27 0.73 1.46 1.32 1.10 0.77 1.21 5.02 2.03 1.11 1.79 1.41 1.46 0.93 1.53 1.23 0.61 1.23 0.98 1.26 0.96 0.98 0.73 1.58 0.87 0.70 1.26 0.77 1.10 1.74 0.62 1.17 1.51 1.04 1.54
ACCEPTED MANUSCRIPT
Wdr82 Dcun1d1 Ppp1r18 Mgat1
Gnl1 Pus1 Nup160 Fryl Tlk2 Tbcb Lims1
93.8717 92.1686 254.997 144.995 109.937 136.182 65.6921 267.116 121.368 134.618 92.9147 204.559 191.142 80.5167 121.947 121.813 73.5598 69.4767 161.58 167.933 179.906 150.055 128.573 248.874 158.215 204.497 178.056 126.655 121.487 142.917 106.4 60.8577 185.56 111.647 91.8733 90.4275 125.4 186.533 117.026 133.769 142.072 203.967 157.012 133.153 122.7 89.4186 222.133 194.971 129.15 115.599 47.6864 175.728 132.727 162.233 182.293 107.228 230.657 155.91 189.025 159.618 122.042 185.604
114.998 127.449 301.887 214.775 134.767 183.259 89.8836 339.256 163.629 182.866 128.254 247.662 282.693 104.439 149.46 137.588 94.3352 99.3158 203.252 232.42 244.686 192.148 159.756 281.813 147.405 289.917 266.416 150.359 156.772 111.303 127.858 84.3699 256.131 143.025 144.843 109.694 104.052 179.442 150.608 149.315 134.59 258.268 198.648 155.668 176.561 107.182 270.298 230.86 172.685 150.115 63.4501 193.383 171.56 164.147 187.527 138.882 293.249 135.282 144.256 180.843 149.098 208.996
RI PT
110.578 109.007 250.52 201.225 119.663 144.385 55.9516 323.445 138.143 153.267 105.814 224.225 225.412 99.7291 117.242 129.238 63.5595 83.768 173.125 189.384 200.075 156.581 127.1 261.084 143.45 258.5 224.302 128.544 130.323 108.203 105.18 65.0863 205.949 121.32 118.034 98.6529 124.217 146.938 120.454 134.579 110.869 276.392 182.178 138.682 167.95 83.0165 214.727 199.033 134.34 135.388 62.0134 153.793 136.34 154.298 188.073 119.496 244.673 156.745 168.843 172.393 119.966 183.966
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
TE D
Dnajc10 Pmvk Glipr2 Tpm3 Kdelc2 Trmt6 Cers2 Vcpip1 Srsf9 Gpx7 Gcat Pdzk1 Jmjd6 Specc1 Gnai2 Ddx18 Btaf1 Tor1a Snx18 Pex13 Pttg1ip Hectd1 Otud4 Athl1 Mrpl44 Arsa Sec24c Aqr Cenpe Gosr1 Gm5069 Exosc7 Pkn1 Sec61a1 Wdr43 Sgcd Adam17 Mon2 Mrpl22 Ttc39b Ddx19b Akr1e2 Creld2 Timm8b Ptges
DPP9_MOUSE Dipeptidyl peptidase 9 EI2BE_MOUSE Translation initiation factor eIF-2B subunit epsilon CS012_MOUSE Protein C19orf12 homolog DJC10_MOUSE DnaJ homolog subfamily C member 10 PMVK_MOUSE Phosphomevalonate kinase GAPR1_MOUSE Golgi-associated plant pathogenesis-related protein 1 TPM3_MOUSE Isoform 2 of Tropomyosin alpha-3 chain G5E897_MOUSE KDEL (Lys-Asp-Glu-Leu) containing 2, isoform CRA_b TRM6_MOUSE tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 CERS2_MOUSE Ceramide synthase 2 VCIP1_MOUSE Deubiquitinating protein VCIP135 SRSF9_MOUSE Serine/arginine-rich splicing factor 9 GPX7_MOUSE Glutathione peroxidase 7 KBL_MOUSE 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial NHRF3_MOUSE Na(+)/H(+) exchange regulatory cofactor NHE-RF3 JMJD6_MOUSE Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 CYTSB_MOUSE Cytospin-B GNAI2_MOUSE Guanine nucleotide-binding protein G(i) subunit alpha-2 DDX18_MOUSE ATP-dependent RNA helicase DDX18 E9QAE3_MOUSE Protein Btaf1 TOR1A_MOUSE Torsin-1A Q8C788_MOUSE Sorting nexin PEX13_MOUSE Peroxisomal membrane protein PEX13 PTTG_MOUSE Pituitary tumor-transforming gene 1 protein-interacting protein HECD1_MOUSE E3 ubiquitin-protein ligase HECTD1 OTUD4_MOUSE OTU domain-containing protein 4 ATHL1_MOUSE Acid trehalase-like protein 1 RM44_MOUSE 39S ribosomal protein L44, mitochondrial ARSA_MOUSE Arylsulfatase A G3X972_MOUSE Protein Sec24c AQR_MOUSE Intron-binding protein aquarius CENPE_MOUSE Centromere-associated protein E GOSR1_MOUSE Golgi SNAP receptor complex member 1 D3Z0Z9_MOUSE Glyceraldehyde-3-phosphate dehydrogenase EXOS7_MOUSE Exosome complex exonuclease RRP42 PKN1_MOUSE Serine/threonine-protein kinase N1 S61A1_MOUSE Protein transport protein Sec61 subunit alpha isoform 1 WDR43_MOUSE WD repeat-containing protein 43 SGCD_MOUSE Delta-sarcoglycan ADA17_MOUSE Disintegrin and metalloproteinase domain-containing protein 17 MON2_MOUSE Protein MON2 homolog RM22_MOUSE 39S ribosomal protein L22, mitochondrial TT39B_MOUSE Tetratricopeptide repeat protein 39B Q8BZY3_MOUSE Protein Ddx19b AKCL2_MOUSE 1,5-anhydro-D-fructose reductase CREL2_MOUSE Cysteine-rich with EGF-like domain protein 2 TIM8B_MOUSE Mitochondrial import inner membrane translocase subunit Tim8 B PTGES_MOUSE Prostaglandin E synthase CI041_MOUSE UPF0586 protein C9orf41 homolog WDR82_MOUSE WD repeat-containing protein 82 DCNL1_MOUSE DCN1-like protein 1 PPR18_MOUSE Phostensin MGAT1_MOUSE Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase CP062_MOUSE UPF0505 protein C16orf62 homolog CJ076_MOUSE UPF0668 protein C10orf76 homolog GNL1_MOUSE Guanine nucleotide-binding protein-like 1 TRUA_MOUSE tRNA pseudouridine synthase A, mitochondrial NU160_MOUSE Nuclear pore complex protein Nup160 F8VQ05_MOUSE Protein Fryl TLK2_MOUSE Serine/threonine-protein kinase tousled-like 2 TBCB_MOUSE Tubulin-folding cofactor B LIMS1_MOUSE LIM and senescent cell antigen-like-containing domain protein 1
EP
Dpp9 Eif2b5
AC C
sp|Q8BVG4|DPP9_MOUSE sp|Q8CHW4|EI2BE_MOUSE sp|Q8WUR0|CS012_MOUSE sp|Q9DC23|DJC10_MOUSE sp|Q9D1G2|PMVK_MOUSE sp|Q9CYL5|GAPR1_MOUSE sp|P21107-2|TPM3_MOUSE tr|G5E897|G5E897_MOUSE sp|Q8CE96|TRM6_MOUSE sp|Q924Z4|CERS2_MOUSE sp|Q8CDG3|VCIP1_MOUSE sp|Q9D0B0|SRSF9_MOUSE sp|Q99LJ6|GPX7_MOUSE sp|O88986|KBL_MOUSE sp|Q9JIL4|NHRF3_MOUSE sp|Q9ERI5|JMJD6_MOUSE sp|Q5SXY1|CYTSB_MOUSE sp|P08752|GNAI2_MOUSE sp|Q8K363|DDX18_MOUSE tr|E9QAE3|E9QAE3_MOUSE sp|Q9ER39|TOR1A_MOUSE tr|Q8C788|Q8C788_MOUSE sp|Q9D0K1|PEX13_MOUSE sp|Q8R143|PTTG_MOUSE sp|Q69ZR2|HECD1_MOUSE sp|B2RRE7|OTUD4_MOUSE sp|Q8BP56|ATHL1_MOUSE sp|Q9CY73|RM44_MOUSE sp|P50428|ARSA_MOUSE tr|G3X972|G3X972_MOUSE sp|Q8CFQ3|AQR_MOUSE sp|Q6RT24|CENPE_MOUSE sp|O88630|GOSR1_MOUSE tr|D3Z0Z9|D3Z0Z9_MOUSE sp|Q9D0M0|EXOS7_MOUSE sp|P70268|PKN1_MOUSE sp|P61620|S61A1_MOUSE sp|Q6ZQL4|WDR43_MOUSE sp|P82347|SGCD_MOUSE sp|Q9Z0F8|ADA17_MOUSE sp|Q80TL7|MON2_MOUSE sp|Q8BU88|RM22_MOUSE sp|Q8BYY4|TT39B_MOUSE tr|Q8BZY3|Q8BZY3_MOUSE sp|Q9DCT1|AKCL2_MOUSE sp|Q9CYA0|CREL2_MOUSE sp|P62077|TIM8B_MOUSE sp|Q9JM51|PTGES_MOUSE sp|Q80UY1|CI041_MOUSE sp|Q8BFQ4|WDR82_MOUSE sp|Q9QZ73|DCNL1_MOUSE sp|Q8BQ30|PPR18_MOUSE sp|P27808|MGAT1_MOUSE sp|Q8BWQ6|CP062_MOUSE sp|Q6PD19|CJ076_MOUSE sp|P36916|GNL1_MOUSE sp|Q9WU56|TRUA_MOUSE sp|Q9Z0W3|NU160_MOUSE tr|F8VQ05|F8VQ05_MOUSE sp|O55047|TLK2_MOUSE sp|Q9D1E6|TBCB_MOUSE sp|Q99JW4|LIMS1_MOUSE
122.858 106.481 285.188 186.102 130.802 140.932 50.4593 342.077 135.445 148.765 100.669 245.991 196.272 102.501 124.882 149.888 62.2967 75.5135 178.094 173.633 186.936 155.08 128.924 293.046 192.281 230.42 185.32 136.112 125.868 170.024 109.125 56.5103 181.629 117.198 89.2227 101.089 174.206 190.97 112.271 146.953 144.428 271.57 175.437 143.785 143.256 82.2955 208.527 200.754 115.386 123.969 56.0523 165.027 120.956 179.76 214.833 107.196 222.619 203.819 243.178 178.59 112.846 190.478
80.709 115.86 164.935 175.75 122.161 193.568 451.073 290.837 115.979 134.595 109.224 179.411 135.738 75.4325 120.654 108.005 93.9007 756.548 128.097 186.801 198.85 133.465 116.665 202.772 117.757 153.733 159.162 81.5068 104.693 223.342 36.643 209.871 242.386 217.371 119.346 100.452 623.006 144.848 127.446 155.334 157.581 104.508 220.223 166.767 140.732 78.9815 114.434 236.823 140.231 129.302 218.845 142.387 143.751 475.336 158.699 168.88 220.797 227.252 248.651 198.192 153.112 430.579
75.6749 95.1324 234.623 124.78 166.714 268.145 1137.69 229.314 108 112.057 226.6 379.279 204.458 76.8979 278.052 140.537 146.178 559.269 55.0823 141.905 158.261 197.726 83.942 127.544 161.167 225.828 118.035 132.395 111.31 202.904 31.5569 270.617 259.929 175.026 98.0943 125.566 396.889 96.9467 112.398 151.423 158.76 244.338 273.332 143.417 150.008 183.046 332.061 177.715 215.468 113.557 174.984 186.332 152.146 299.846 124.875 124.174 184.432 153.398 285.645 149.75 283.884 589.047
1.16 1.16 1.16 1.16 1.16 1.16 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.14 1.14 1.14 1.14 1.14 1.13 1.13 1.13 1.13 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.11 1.11 1.11 1.11 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.08 1.08 1.08 1.08 1.08
0.76 1.05 0.79 0.87 1.26 1.65 13.06 0.88 0.86 0.86 1.69 1.30 0.82 0.85 1.67 0.99 1.75 8.59 0.55 0.92 0.94 1.08 0.78 0.65 0.92 0.82 0.69 0.84 0.86 1.70 0.32 3.82 1.28 1.68 1.04 1.20 4.09 0.73 1.01 1.14 1.25 0.73 1.46 1.14 1.00 1.52 1.02 1.05 1.35 0.97 3.59 1.00 1.10 2.45 0.77 1.29 0.85 1.22 1.49 1.05 1.81 2.76
ACCEPTED MANUSCRIPT
Cacul1 Aga Nt5c2 Nudt4 Raver1 Mtif3 Oxsm Ctr9 Vldlr Spag7 Farp2 Triobp Rpl37a Prps2 Fyco1 Zc3h4 Aamdc Ssr4 Carm1 Gga2
178.676 121.152 172.435 131.331 212.582 104.691 186.582 96.9483 73.8867 143.853 217.256 76.6089 170.97 142.323 209.321 88.5361 192.026 143.951 181.17 225.588 56.4126 108.363 101.709 128.377 95.5672 104.081 85.798 38.8107 170.249 151.089 74.3675 134.978 121.145 85.663 148.421 106.863 197.697 284.713 111.617 257.097 209.496 95.8069 129.383 66.815 119.432 95.387 146.065 315.643 78.0293 151.415 136.385 200.774 154.817 109.33 127.804 66.6535 163.88 93.0836 216.831 326.731 212.881 116.739
197.511 146.343 193.621 160.855 205.901 127.866 235.588 128.764 97.2454 176.683 287.017 106.836 228.011 175.242 257.897 111.386 210.241 160.983 191.196 250.928 63.1328 126.583 110.688 149.879 115.633 112.024 104.669 45.7908 197.96 204.687 87.113 137.78 167.053 99.3476 165.661 153.555 190.602 375.883 141.372 208.18 209.444 97.8965 157.28 85.8756 163.609 115.338 189.943 371.534 78.6539 163.265 131.109 214.426 151.186 106.665 71.0454 64.8464 202.745 100.439 264.677 293.651 214.281 155.954
RI PT
160.28 119.151 187.087 141.828 190.583 120.098 204.099 129.167 85.6791 150.038 261.905 77.306 202.019 145.626 208.807 100.99 178.917 127.204 182.01 240.698 53.4245 105.203 94.6186 134.586 105.932 103.837 97.9827 36.1835 176.628 170.773 82.1235 95.8268 145.449 85.6778 126.335 148.281 154.875 332.766 122.834 203.423 207.698 87.4921 136.912 63.6822 146.691 98.1171 161.932 316.297 73.5045 169.068 121.199 168.085 172.045 103.369 124.208 56.5543 182.725 85.2608 229.928 336.611 259.585 141.114
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
Entpd6 Ripk2 Tmem263 Agt Bet1 Rabep2 Nfkb2 Znf830 Lcmt1 Coa6 Aamp Ash2l
TE D
Zcchc24 Obfc1 Stx6 Phpt1 Scyl2 Ccdc127 Mrpl20 Ppp2r5c Praf2 Mcl1 Anapc5 Ptk2b Nars2 Txnrd3 Ppp2ca
BCL9L_MOUSE B-cell CLL/lymphoma 9-like protein SLMAP_MOUSE Sarcolemmal membrane-associated protein RTN3_MOUSE Reticulon-3 CHMP7_MOUSE Charged multivesicular body protein 7 GNL3_MOUSE Guanine nucleotide-binding protein-like 3 SNP47_MOUSE Synaptosomal-associated protein 47 DCTN4_MOUSE Dynactin subunit 4 PTER_MOUSE Phosphotriesterase-related protein WDR44_MOUSE WD repeat-containing protein 44 STK4_MOUSE Serine/threonine-protein kinase 4 OSBL9_MOUSE Oxysterol-binding protein-related protein 9 SH3L1_MOUSE SH3 domain-binding glutamic acid-rich-like protein CC033_MOUSE Protein C3orf33 homolog ZCH24_MOUSE Zinc finger CCHC domain-containing protein 24 STN1_MOUSE CST complex subunit STN1 STX6_MOUSE Syntaxin-6 PHP14_MOUSE 14 kDa phosphohistidine phosphatase SCYL2_MOUSE SCY1-like protein 2 CC127_MOUSE Coiled-coil domain-containing protein 127 RM20_MOUSE 39S ribosomal protein L20, mitochondrial 2A5G_MOUSE Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform PRAF2_MOUSE PRA1 family protein 2 MCL1_MOUSE Induced myeloid leukemia cell differentiation protein Mcl-1 homolog APC5_MOUSE Anaphase-promoting complex subunit 5 FAK2_MOUSE Protein-tyrosine kinase 2-beta SYNM_MOUSE Probable asparagine--tRNA ligase, mitochondrial TRXR3_MOUSE Thioredoxin reductase 3 PP2AA_MOUSE Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform DIA1_MOUSE Deleted in autism protein 1 homolog Q3U0P5_MOUSE Ectonucleoside triphosphate diphosphohydrolase 6, isoform CRA_a RIPK2_MOUSE Receptor-interacting serine/threonine-protein kinase 2 TM263_MOUSE Transmembrane protein 263 ANGT_MOUSE Angiotensinogen BET1_MOUSE BET1 homolog RABE2_MOUSE Rab GTPase-binding effector protein 2 NFKB2_MOUSE Nuclear factor NF-kappa-B p100 subunit ZN830_MOUSE Zinc finger protein 830 A2RTH5_MOUSE Leucine carboxyl methyltransferase 1 COA6_MOUSE Cytochrome c oxidase assembly factor 6 homolog J3QN89_MOUSE Protein Aamp ASH2L_MOUSE Set1/Ash2 histone methyltransferase complex subunit ASH2 CH037_MOUSE Protein C8orf37 homolog CACL1_MOUSE CDK2-associated and cullin domain-containing protein 1 ASPG_MOUSE N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase 5NTC_MOUSE Cytosolic purine 5'-nucleotidase NUDT4_MOUSE Diphosphoinositol polyphosphate phosphohydrolase 2 RAVR1_MOUSE Ribonucleoprotein PTB-binding 1 IF3M_MOUSE Translation initiation factor IF-3, mitochondrial OXSM_MOUSE 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial CTR9_MOUSE RNA polymerase-associated protein CTR9 homolog VLDLR_MOUSE Very low-density lipoprotein receptor SPAG7_MOUSE Sperm-associated antigen 7 FARP2_MOUSE FERM, RhoGEF and pleckstrin domain-containing protein 2 TARA_MOUSE TRIO and F-actin-binding protein RL37A_MOUSE 60S ribosomal protein L37a PRPS2_MOUSE Ribose-phosphate pyrophosphokinase 2 FYCO1_MOUSE FYVE and coiled-coil domain-containing protein 1 ZC3H4_MOUSE Zinc finger CCCH domain-containing protein 4 AAMDC_MOUSE Mth938 domain-containing protein SSRD_MOUSE Translocon-associated protein subunit delta CARM1_MOUSE Histone-arginine methyltransferase CARM1 GGA2_MOUSE ADP-ribosylation factor-binding protein GGA2
EP
Bcl9l Slmap Rtn3 Chmp7 Gnl3 Snap47 Dctn4 Pter Wdr44 Stk4 Osbpl9 Sh3bgrl
AC C
sp|Q67FY2|BCL9L_MOUSE sp|Q3URD3|SLMAP_MOUSE sp|Q9ES97|RTN3_MOUSE sp|Q8R1T1|CHMP7_MOUSE sp|Q8CI11|GNL3_MOUSE sp|Q8R570|SNP47_MOUSE sp|Q8CBY8|DCTN4_MOUSE sp|Q60866|PTER_MOUSE sp|Q6NVE8|WDR44_MOUSE sp|Q9JI11|STK4_MOUSE sp|A2A8Z1|OSBL9_MOUSE sp|Q9JJU8|SH3L1_MOUSE sp|Q8BN57|CC033_MOUSE sp|B2RVL6|ZCH24_MOUSE sp|Q8K2X3|STN1_MOUSE sp|Q9JKK1|STX6_MOUSE sp|Q9DAK9|PHP14_MOUSE sp|Q8CFE4|SCYL2_MOUSE sp|Q3TC33|CC127_MOUSE sp|Q9CQL4|RM20_MOUSE sp|Q60996|2A5G_MOUSE sp|Q9JIG8|PRAF2_MOUSE sp|P97287|MCL1_MOUSE sp|Q8BTZ4|APC5_MOUSE sp|Q9QVP9|FAK2_MOUSE sp|Q8BGV0|SYNM_MOUSE sp|Q99MD6|TRXR3_MOUSE sp|P63330|PP2AA_MOUSE sp|Q3USZ8|DIA1_MOUSE tr|Q3U0P5|Q3U0P5_MOUSE sp|P58801|RIPK2_MOUSE sp|Q9DAM7|TM263_MOUSE sp|P11859|ANGT_MOUSE sp|O35623|BET1_MOUSE sp|Q91WG2|RABE2_MOUSE sp|Q9WTK5|NFKB2_MOUSE sp|Q8R1N0|ZN830_MOUSE tr|A2RTH5|A2RTH5_MOUSE sp|Q8BGD8|COA6_MOUSE tr|J3QN89|J3QN89_MOUSE sp|Q91X20|ASH2L_MOUSE sp|Q3UJP5|CH037_MOUSE sp|Q8R0X2|CACL1_MOUSE sp|Q64191|ASPG_MOUSE sp|Q3V1L4|5NTC_MOUSE sp|Q8R2U6|NUDT4_MOUSE sp|Q9CW46|RAVR1_MOUSE sp|Q9CZD5|IF3M_MOUSE sp|Q9D404|OXSM_MOUSE sp|Q62018|CTR9_MOUSE sp|P98156|VLDLR_MOUSE sp|Q7TNE3|SPAG7_MOUSE sp|Q91VS8|FARP2_MOUSE sp|Q99KW3|TARA_MOUSE sp|P61514|RL37A_MOUSE sp|Q9CS42|PRPS2_MOUSE sp|Q8VDC1|FYCO1_MOUSE sp|Q6ZPZ3|ZC3H4_MOUSE sp|Q8R0P4|AAMDC_MOUSE sp|Q62186|SSRD_MOUSE sp|Q9WVG6|CARM1_MOUSE sp|Q6P5E6|GGA2_MOUSE
168.459 113.011 194.168 133.645 228.652 113.949 184.503 114.178 73.9894 138.159 226.29 58.0411 171.401 133.021 189.507 91.334 186.199 128.768 196.614 246.701 53.996 101.036 98.3868 129.926 98.7277 109.148 90.7957 33.9682 170.848 137.484 79.0198 106.94 115.186 81.6075 124.389 115.769 181.513 274.385 105.377 276.139 229.019 94.708 122.352 50.9197 115.283 87.4317 132.441 289.646 79.8808 171.866 137.657 169.513 188.997 114.395 190.701 62.9437 156.25 84.1943 196.863 391.485 273.59 109.236
158.579 98.2891 192.539 122.376 419.741 86.0101 240.389 103.192 65.468 136.608 211.755 606.707 127.603 145.965 237.889 88.8268 100.341 190.582 249.242 119.964 545.701 139.603 80.7373 101.49 169.941 171.934 197.111 565.81 127.543 178.881 71.02 115.953 34.0573 142.104 112.571 140.46 94.2001 319.575 61.2643 161.901 181.386 43.5421 130.656 38.5865 66.4581 56.4641 168.015 157.15 258.354 228.775 210.379 112.264 169.629 107.557 244.359 201.693 242.677 72.5133 82.0332 412.168 239.78 88.7046
200.286 158.237 166.407 118.978 336.567 93.6001 222.749 113.918 147.089 147.549 389.19 1460.59 150.531 349.954 192.835 154.563 227.548 176.62 132.77 194.588 595.64 82.3842 88.5649 94.8008 222.219 206.888 118.49 709.462 97.9663 214.67 72.0446 201.617 105.687 101.82 214.785 133.989 180.96 311.02 192.624 352.823 242.002 98.1249 110.086 66.8492 100.241 153.549 227.426 388.991 257.611 164.501 175.733 317.429 153.379 169.335 179.325 178.957 279.448 146.249 260.443 288.824 188.925 135.296
1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.03 1.03 1.03 1.03
1.06 1.07 1.00 0.88 1.88 0.80 1.19 0.96 1.33 0.97 1.25 13.43 0.75 1.72 1.03 1.28 0.88 1.35 1.05 0.67 10.39 1.04 0.86 0.75 1.95 1.82 1.72 17.00 0.65 1.22 0.91 1.38 0.52 1.42 1.19 1.08 0.78 1.02 1.08 1.12 1.01 0.77 0.90 0.81 0.63 1.09 1.28 0.86 3.40 1.23 1.50 1.16 0.99 1.30 1.68 3.09 1.51 1.23 0.77 1.06 0.91 0.87
ACCEPTED MANUSCRIPT
TE D
106.404 92.9848 173.138 130.293 180.95 64.7292 95.0562 238.727 185.307 169.134 139.692 120.994 292.102 107.575 189.774 120.77 212.699 164.805 117.881 158.411 69.6387 120.906 179.38 131.329 118.229 123.562 190.499 96.2127 174.446 349.551 168.486 133.823 177.964 403.885 247.393 174.553 170.523 135.194 154.268 175.745 186.708 196.28 127.216 193.008 71.4641 162.137 269.667 123.732 179.478 82.3216 163.749 168.098 188.285 99.7295 116.683 161.338 118.562 180.067 147.047 87.698 106.207 221.679
130.627 79.719 194.225 109.866 211.208 68.9605 113.913 290.692 226.487 135.756 148.434 140.481 292.072 144.906 208.455 117.207 229.808 163.657 96.7711 183.905 76.7881 144.438 216.297 123.491 127.87 131.497 220.223 114.752 190.885 365.348 159.879 141.997 197.441 437.203 220.233 199.094 158.418 140.47 160.965 181.901 152.059 203.481 134.062 197.459 64.8355 190.605 255.579 122.797 103.901 97.4645 192.581 156.579 199.319 104.432 134.182 154.565 132.39 189.047 150.981 72.3891 84.3453 237.253
RI PT
123.31 85.9605 155.699 119.189 184.313 66.7355 89.7287 269.57 230.721 140.045 127.84 137.271 282.701 131.158 207.932 124.119 196.667 142.967 96.5428 164.139 66.0281 127.259 197.15 143.052 121.048 119.858 216.932 111.134 183.481 311.857 149.485 120.539 176.601 422.34 255.078 183.801 151.604 125.914 146.118 168.907 140.574 212.243 121.228 176.849 51.0612 206.163 273.55 115.206 115.416 111.317 189.06 147.54 191.802 93.2708 140.28 172.874 128.603 176.673 157.756 67.398 91.3049 282.638
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
MACD1_MOUSE O-acetyl-ADP-ribose deacetylase MACROD1 KC1A_MOUSE Casein kinase I isoform alpha Q6XLQ8_MOUSE Calumenin CSN8_MOUSE COP9 signalosome complex subunit 8 DCUP_MOUSE Uroporphyrinogen decarboxylase CC115_MOUSE Coiled-coil domain-containing protein 115 D3Z0Y2_MOUSE Peroxiredoxin-6 PI42C_MOUSE Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma SC24A_MOUSE Protein transport protein Sec24A PSMG2_MOUSE Proteasome assembly chaperone 2 AFTIN_MOUSE Aftiphilin PTH2_MOUSE Peptidyl-tRNA hydrolase 2, mitochondrial MYO6_MOUSE Unconventional myosin-VI ACL6A_MOUSE Actin-like protein 6A RM14_MOUSE 39S ribosomal protein L14, mitochondrial 2A5E_MOUSE Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform COXM1_MOUSE COX assembly mitochondrial protein homolog CLIP2_MOUSE CAP-Gly domain-containing linker protein 2 RIC1_MOUSE Protein RIC1 homolog KI13A_MOUSE Kinesin-like protein KIF13A MED8_MOUSE Mediator of RNA polymerase II transcription subunit 8 SRSF4_MOUSE Serine/arginine-rich splicing factor 4 DLP1_MOUSE Decaprenyl-diphosphate synthase subunit 2 SAC1_MOUSE Phosphatidylinositide phosphatase SAC1 NUDT3_MOUSE Diphosphoinositol polyphosphate phosphohydrolase 1 ERLEC_MOUSE Endoplasmic reticulum lectin 1 SPS1_MOUSE Selenide, water dikinase 1 COMD7_MOUSE COMM domain-containing protein 7 SEPT5_MOUSE Septin-5 RWDD1_MOUSE RWD domain-containing protein 1 NCOR1_MOUSE Nuclear receptor corepressor 1 ATF7_MOUSE Cyclic AMP-dependent transcription factor ATF-7 RBM10_MOUSE RNA-binding protein 10 NAA10_MOUSE N-alpha-acetyltransferase 10 SPCS3_MOUSE Signal peptidase complex subunit 3 SMAP1_MOUSE Stromal membrane-associated protein 1 UB2R2_MOUSE Ubiquitin-conjugating enzyme E2 R2 BICD2_MOUSE Protein bicaudal D homolog 2 DCTP1_MOUSE dCTP pyrophosphatase 1 NCK1_MOUSE Cytoplasmic protein NCK1 NCOR2_MOUSE Nuclear receptor corepressor 2 DYLT1_MOUSE Dynein light chain Tctex-type 1 CREB1_MOUSE Cyclic AMP-responsive element-binding protein 1 ZC3HE_MOUSE Zinc finger CCCH domain-containing protein 14 EIF2D_MOUSE Eukaryotic translation initiation factor 2D ILVBL_MOUSE Acetolactate synthase-like protein SCAF8_MOUSE Protein SCAF8 CC124_MOUSE Coiled-coil domain-containing protein 124 LTOR5_MOUSE Ragulator complex protein LAMTOR5 RMND1_MOUSE Required for meiotic nuclear division protein 1 homolog Q8CIH9_MOUSE Amidophosphoribosyltransferase RM46_MOUSE 39S ribosomal protein L46, mitochondrial SYDM_MOUSE Aspartate--tRNA ligase, mitochondrial PCM1_MOUSE Pericentriolar material 1 protein Q3ULW8_MOUSE Protein Parp3 UBP38_MOUSE Ubiquitin carboxyl-terminal hydrolase 38 TPM2_MOUSE Tropomyosin beta chain TOX4_MOUSE TOX high mobility group box family member 4 FAD1_MOUSE FAD synthase RS26_MOUSE 40S ribosomal protein S26 FHOD1_MOUSE FH1/FH2 domain-containing protein 1 SYFM_MOUSE Phenylalanine--tRNA ligase, mitochondrial
EP
Macrod1 Csnk1a1 Calu Cops8 Urod Ccdc115 Prdx6 Pip4k2c Sec24a Psmg2 Aftph Ptrh2 Myo6 Actl6a Mrpl14 Ppp2r5e Cmc1 Clip2 Kiaa1432 Kif13a Med8 Srsf4 Pdss2 Sacm1l Nudt3 Erlec1 Sephs1 Commd7 05-Sep Rwdd1 Ncor1 Atf7 Rbm10 Naa10 Spcs3 Smap1 Ube2r2 Bicd2 Dctpp1 Nck1 Ncor2 Dynlt1 Creb1 Zc3h14 Eif2d Ilvbl Scaf8 Ccdc124 Lamtor5 Rmnd1 Ppat Mrpl46 Dars2 Pcm1 Parp3 Usp38 Tpm2 Tox4 Flad1 Rps26 Fhod1 Fars2
AC C
sp|Q922B1|MACD1_MOUSE sp|Q8BK63|KC1A_MOUSE tr|Q6XLQ8|Q6XLQ8_MOUSE sp|Q8VBV7|CSN8_MOUSE sp|P70697|DCUP_MOUSE sp|Q8VE99|CC115_MOUSE tr|D3Z0Y2|D3Z0Y2_MOUSE sp|Q91XU3|PI42C_MOUSE sp|Q3U2P1|SC24A_MOUSE sp|Q9EST4|PSMG2_MOUSE sp|Q80WT5|AFTIN_MOUSE sp|Q8R2Y8|PTH2_MOUSE sp|Q64331|MYO6_MOUSE sp|Q9Z2N8|ACL6A_MOUSE sp|Q9D1I6|RM14_MOUSE sp|Q61151|2A5E_MOUSE sp|Q9CPZ8|COXM1_MOUSE sp|Q9Z0H8|CLIP2_MOUSE sp|Q69ZJ7|RIC1_MOUSE sp|Q9EQW7|KI13A_MOUSE sp|Q9D7W5|MED8_MOUSE sp|Q8VE97|SRSF4_MOUSE sp|Q33DR3|DLP1_MOUSE sp|Q9EP69|SAC1_MOUSE sp|Q9JI46|NUDT3_MOUSE sp|Q8VEH8|ERLEC_MOUSE sp|Q8BH69|SPS1_MOUSE sp|Q8BG94|COMD7_MOUSE sp|Q9Z2Q6|SEPT5_MOUSE sp|Q9CQK7|RWDD1_MOUSE sp|Q60974|NCOR1_MOUSE sp|Q8R0S1|ATF7_MOUSE sp|Q99KG3|RBM10_MOUSE sp|Q9QY36|NAA10_MOUSE sp|Q9D365|SPCS3_MOUSE sp|Q91VZ6|SMAP1_MOUSE sp|Q6ZWZ2|UB2R2_MOUSE sp|Q921C5|BICD2_MOUSE sp|Q9QY93|DCTP1_MOUSE sp|Q99M51|NCK1_MOUSE sp|Q9WU42|NCOR2_MOUSE sp|P51807|DYLT1_MOUSE sp|Q01147|CREB1_MOUSE sp|Q8BJ05|ZC3HE_MOUSE sp|Q61211|EIF2D_MOUSE sp|Q8BU33|ILVBL_MOUSE sp|Q6DID3|SCAF8_MOUSE sp|Q9D8X2|CC124_MOUSE sp|Q9D1L9|LTOR5_MOUSE sp|Q8CI78|RMND1_MOUSE tr|Q8CIH9|Q8CIH9_MOUSE sp|Q9EQI8|RM46_MOUSE sp|Q8BIP0|SYDM_MOUSE sp|Q9R0L6|PCM1_MOUSE tr|Q3ULW8|Q3ULW8_MOUSE sp|Q8BW70|UBP38_MOUSE sp|P58774|TPM2_MOUSE sp|Q8BU11|TOX4_MOUSE sp|Q8R123|FAD1_MOUSE sp|P62855|RS26_MOUSE sp|Q6P9Q4|FHOD1_MOUSE sp|Q99M01|SYFM_MOUSE
105.355 104.03 143.245 145.705 162.922 65.5684 74.7166 227.883 197.718 179.427 123.724 121.661 291.249 97.3457 193.845 130.467 183.584 146.386 119.184 140.814 59.5353 104.817 161.886 151.883 111.946 111.96 184.718 90.4427 162.594 286.171 153.147 108.144 150.96 373.817 272.817 152.226 157.385 114.91 132.771 155.043 167.786 195.412 108.503 162.641 54.1735 166.8 271.523 109.038 182.089 90.2415 148.524 148.323 167.529 81.4156 113.234 166.75 104.594 152.946 141.053 75.8144 102.775 240.502
291.926 72.1023 141.166 120.793 167.047 105.544 63.8858 194.417 356.107 487.626 102.467 151.026 345.634 113.859 106.219 98.0145 141.485 155.556 136.927 147.261 53.4406 69.1408 168.94 112.688 94.1985 79.7654 191.601 84.0298 143.391 284.347 143.313 121.06 245.782 420.828 248.023 112.265 132.676 116.937 25.6016 121.436 176.338 172.596 181.303 111.622 306.017 146.484 382.914 122.071 75.9225 181.95 277.121 73.1037 144.384 47.8766 88.0256 99.8903 522.963 113.838 273.385 215.031 191.936 172.771
610.326 61.6031 238.011 245.121 204.754 244.423 142.813 291.098 323.162 411.693 219.328 162.2 343.615 105.253 223.641 99.286 519.21 386.934 119.356 186.778 112.286 178.455 188.848 126.743 143.956 147.33 273.306 68.0135 155.123 489.446 394.468 250.09 584.57 530.416 256.186 118.379 278.212 217.61 177.267 197.881 471.706 227.099 295.383 212.077 365.318 115.771 418.171 179.414 463.484 107.006 205.542 164.854 215.481 90.3435 93.4762 122.088 844.332 217.226 287.081 280.857 167.238 231.125
1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.00 1.00 1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.95 0.95
3.93 0.75 1.15 1.47 1.02 2.66 1.12 0.96 1.63 2.91 1.20 1.21 1.20 0.92 0.83 0.81 1.61 1.76 1.20 1.04 1.22 1.00 0.95 0.87 1.00 0.93 1.14 0.73 0.83 1.17 1.69 1.46 2.34 1.15 1.00 0.64 1.28 1.28 0.68 0.93 1.98 0.98 1.92 0.88 5.48 0.71 1.47 1.26 1.83 1.49 1.37 0.75 0.95 0.72 0.71 0.66 5.53 0.93 1.84 3.20 1.82 0.80
ACCEPTED MANUSCRIPT
Enoph1 Polr2e Cln5 Ctif Msi2 Ltbp3 Vamp3 Pcmtd1 Ppp6c Ubr7 Anapc4 Ankrd44 Strn4 Ap1s1 Rtf1 Srek1 Rilpl1
TE D
122.351 185.319 126.643 156.198 64.8979 275.441 299.37 298.203 204.125 194.035 228.369 92.8944 109.635 191.14 198.829 157.097 68.8346 132.93 227.649 210.746 226.326 137.341 294.209 172.05 176.935 149.554 193.059 160.288 139.789 229.867 201.274 159.343 195.688 141.224 130.196 147.58 110.91 176.024 109.882 254.573 105.919 264.133 166.813 134.116 230.905 158.067 160.459 229.993 254.15 171.924 169.13 121.79 225.691 171.451 175.524 131.27 127.213 146.851 126.614 158.529 117.127 251.261
129.999 135.918 114.652 149.554 63.0223 341.036 180.014 310.582 224.123 204.292 248.362 110.924 116.227 151.65 213.28 113.793 64.9699 116.391 227.209 215.21 220.397 146.174 261.023 158.459 195.719 149.09 187.842 151.715 137.77 170.387 194.601 164.439 216.336 196.358 146.816 153.517 113.36 172.79 98.9374 262.846 121.189 230.981 156.696 139.144 223.831 172.833 136.278 224.172 227.003 144.663 142.33 119.75 241.243 178.144 149.493 100.151 128.493 133.765 97.0202 168.554 113.446 264.472
RI PT
131.075 157.082 102.529 138.057 62.2657 348.372 301.416 305.401 213.184 219.752 216.819 111.071 126.438 187.998 198.894 102.69 62.111 140.934 206.384 201.689 204.506 137.877 289.693 187.001 189.92 162.137 174.354 140.595 136.942 147.636 173.618 176.357 227.83 219.673 146.538 187.71 131.69 187.635 132.199 265.471 129.877 244.923 159.547 160.238 224.989 212.98 165.502 337.943 263.504 179.838 141.074 126.716 273.061 216.825 157.345 136.716 136.788 136.221 147.011 175.895 123.26 293.126
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
ARFP2_MOUSE Arfaptin-2 VPS53_MOUSE Vacuolar protein sorting-associated protein 53 homolog PHAX_MOUSE Phosphorylated adapter RNA export protein KLC4_MOUSE Kinesin light chain 4 TNG2_MOUSE Transport and Golgi organization 2 homolog ANX11_MOUSE Annexin A11 EDNRA_MOUSE Endothelin-1 receptor ZCHC8_MOUSE Zinc finger CCHC domain-containing protein 8 DDI2_MOUSE Protein DDI1 homolog 2 YTHD1_MOUSE YTH domain-containing family protein 1 CBX5_MOUSE Chromobox protein homolog 5 PITH1_MOUSE PITH domain-containing protein 1 PDCD6_MOUSE Programmed cell death protein 6 SURF4_MOUSE Surfeit locus protein 4 OLM2B_MOUSE Olfactomedin-like protein 2B GBRL2_MOUSE Gamma-aminobutyric acid receptor-associated protein-like 2 CHCH2_MOUSE Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial GNAO_MOUSE Isoform Alpha-2 of Guanine nucleotide-binding protein G(o) subunit alpha FL2D_MOUSE Pre-mRNA-splicing regulator WTAP ASUN_MOUSE Protein asunder homolog FRG1_MOUSE Protein FRG1 COMD9_MOUSE COMM domain-containing protein 9 M4K4_MOUSE Mitogen-activated protein kinase kinase kinase kinase 4 TPPC4_MOUSE Trafficking protein particle complex subunit 4 K0907_MOUSE UPF0469 protein KIAA0907 GABPA_MOUSE GA-binding protein alpha chain MAT1_MOUSE CDK-activating kinase assembly factor MAT1 RYBP_MOUSE RING1 and YY1-binding protein RBM33_MOUSE RNA-binding protein 33 PRC2B_MOUSE Protein PRRC2B MKL2_MOUSE MKL/myocardin-like protein 2 B1ATE0_MOUSE Protein Sgsh MARE3_MOUSE Microtubule-associated protein RP/EB family member 3 FOXK1_MOUSE Forkhead box protein K1 KATL1_MOUSE Katanin p60 ATPase-containing subunit A-like 1 MK14_MOUSE Mitogen-activated protein kinase 14 GTPC1_MOUSE Putative GTP cyclohydrolase 1 type 2 Nif3l1 CRADD_MOUSE Death domain-containing protein CRADD NFIX_MOUSE Nuclear factor 1 X-type BAZ2A_MOUSE Bromodomain adjacent to zinc finger domain protein 2A PPIL1_MOUSE Peptidyl-prolyl cis-trans isomerase-like 1 VP37A_MOUSE Vacuolar protein sorting-associated protein 37A RBM27_MOUSE RNA-binding protein 27 GGH_MOUSE Gamma-glutamyl hydrolase CQ085_MOUSE Uncharacterized protein C17orf85 homolog ENOPH_MOUSE Enolase-phosphatase E1 RPAB1_MOUSE DNA-directed RNA polymerases I, II, and III subunit RPABC1 CLN5_MOUSE Ceroid-lipofuscinosis neuronal protein 5 homolog CTIF_MOUSE CBP80/20-dependent translation initiation factor MSI2H_MOUSE RNA-binding protein Musashi homolog 2 LTBP3_MOUSE Latent-transforming growth factor beta-binding protein 3 VAMP3_MOUSE Vesicle-associated membrane protein 3 PCMD1_MOUSE Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 PPP6_MOUSE Serine/threonine-protein phosphatase 6 catalytic subunit UBR7_MOUSE Putative E3 ubiquitin-protein ligase UBR7 APC4_MOUSE Anaphase-promoting complex subunit 4 ANR44_MOUSE Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B STRN4_MOUSE Striatin-4 AP1S1_MOUSE AP-1 complex subunit sigma-1A RTF1_MOUSE RNA polymerase-associated protein RTF1 homolog SREK1_MOUSE Splicing regulatory glutamine/lysine-rich protein 1 RIPL1_MOUSE RILP-like protein 1
EP
Arfip2 Vps53 Phax Klc4 Tango2 Anxa11 Ednra Zcchc8 Ddi2 Ythdf1 Cbx5 Pithd1 Pdcd6 Surf4 Olfml2b Gabarapl2 Chchd2 Gnao1 Wtap Asun Frg1 Commd9 Map4k4 Trappc4 Kiaa0907 Gabpa Mnat1 Rybp Rbm33 Prrc2b Mkl2 Sgsh Mapre3 Foxk1 Katnal1 Mapk14 Nif3l1 Cradd Nfix Baz2a Ppil1 Vps37a Rbm27 Ggh
AC C
sp|Q8K221|ARFP2_MOUSE sp|Q8CCB4|VPS53_MOUSE sp|Q9JJT9|PHAX_MOUSE sp|Q9DBS5|KLC4_MOUSE sp|P54797|TNG2_MOUSE sp|P97384|ANX11_MOUSE sp|Q61614|EDNRA_MOUSE sp|Q9CYA6|ZCHC8_MOUSE sp|A2ADY9|DDI2_MOUSE sp|P59326|YTHD1_MOUSE sp|Q61686|CBX5_MOUSE sp|Q8BWR2|PITH1_MOUSE sp|P12815|PDCD6_MOUSE sp|Q64310|SURF4_MOUSE sp|Q3V1G4|OLM2B_MOUSE sp|P60521|GBRL2_MOUSE sp|Q9D1L0|CHCH2_MOUSE sp|P18872-2|GNAO_MOUSE sp|Q9ER69|FL2D_MOUSE sp|Q8QZV7|ASUN_MOUSE sp|P97376|FRG1_MOUSE sp|Q8K2Q0|COMD9_MOUSE sp|P97820|M4K4_MOUSE sp|Q9ES56|TPPC4_MOUSE sp|Q3TCX3|K0907_MOUSE sp|Q00422|GABPA_MOUSE sp|P51949|MAT1_MOUSE sp|Q8CCI5|RYBP_MOUSE sp|Q9CXK9|RBM33_MOUSE sp|Q7TPM1|PRC2B_MOUSE sp|P59759|MKL2_MOUSE tr|B1ATE0|B1ATE0_MOUSE sp|Q6PER3|MARE3_MOUSE sp|P42128|FOXK1_MOUSE sp|Q8K0T4|KATL1_MOUSE sp|P47811|MK14_MOUSE sp|Q9EQ80|GTPC1_MOUSE sp|O88843|CRADD_MOUSE sp|P70257|NFIX_MOUSE sp|Q91YE5|BAZ2A_MOUSE sp|Q9D0W5|PPIL1_MOUSE sp|Q8CHS8|VP37A_MOUSE sp|Q5SFM8|RBM27_MOUSE sp|Q9Z0L8|GGH_MOUSE sp|Q8BZR9|CQ085_MOUSE sp|Q8BGB7|ENOPH_MOUSE sp|Q80UW8|RPAB1_MOUSE sp|Q3UMW8|CLN5_MOUSE sp|Q6PEE2|CTIF_MOUSE sp|Q920Q6|MSI2H_MOUSE sp|Q61810|LTBP3_MOUSE sp|P63024|VAMP3_MOUSE sp|P59913|PCMD1_MOUSE sp|Q9CQR6|PPP6_MOUSE sp|Q8BU04|UBR7_MOUSE sp|Q91W96|APC4_MOUSE sp|B2RXR6|ANR44_MOUSE sp|P58404|STRN4_MOUSE sp|P61967|AP1S1_MOUSE sp|A2AQ19|RTF1_MOUSE sp|Q8BZX4|SREK1_MOUSE sp|Q9JJC6|RIPL1_MOUSE
110.052 187.835 101.867 128.364 57.0281 247.383 386.556 258.607 169.262 185.394 170.188 80.7067 105.403 202.009 157.694 128.478 56.8805 138.366 176.073 167.272 178.748 108.75 279.794 173.757 142.976 138.106 150.526 124.5 116.266 174.777 146.956 140.984 168.79 131.08 104.235 149.459 105.699 155.54 119.099 202.452 89.4944 222.98 133.138 122.176 179.525 155.427 151.778 277.387 229.653 165.311 130.822 98.7588 196.253 162.379 139.27 131.633 99.2057 110.38 138.796 119.519 93.3596 203.581
106.72 187.282 131.735 205.889 45.8642 169.065 216.755 274.289 245.152 341.125 84.4109 106.125 153.907 248.853 83.261 140.118 93.7221 293.068 93.0352 131.126 267.978 102.549 300.007 149.691 132.384 149.399 133.123 152.971 88.372 65.4166 96.4865 120.279 184.343 180.827 393.114 129.236 167.038 102.158 401.538 629.544 102.796 178.432 186.212 100.188 144.86 163.267 174.071 159.84 225.386 163.497 100.34 103.342 139.171 171.589 93.2703 97.0225 165.979 110.864 120.596 155.384 77.5889 180.276
102.491 149.96 473.451 281.166 81.2202 176.042 201.715 380.107 414.54 517.924 150.645 83.3106 123.718 174.521 308.252 268.265 125.853 304.65 189.641 170.685 395.151 120.672 529.092 147.84 185.395 223.463 203.877 366.68 211.935 151.273 133.324 220.92 208.64 165.026 423.42 155.118 151.874 162.313 209.66 575.993 144.317 442.689 347.811 108.076 261.05 130.308 207.3 114.478 273.711 283.656 304.292 86.4612 232.216 283.419 188.121 97.6634 123.632 222.108 141.115 236.26 167.109 353.205
0.95 0.95 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.92 0.92 0.92 0.92 0.92 0.91 0.91 0.91 0.91 0.91 0.91 0.90 0.90 0.90 0.90 0.89 0.89 0.89 0.89 0.89 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.87 0.86 0.86 0.86 0.86 0.86 0.86 0.86
0.83 0.98 2.64 1.66 1.00 0.55 0.70 1.08 1.58 2.08 0.53 0.93 1.18 1.12 0.98 1.57 1.68 2.18 0.65 0.73 1.54 0.81 1.42 0.83 0.87 1.20 0.92 1.73 1.09 0.57 0.61 1.02 0.93 0.96 2.95 0.85 1.31 0.73 2.52 2.32 1.05 1.22 1.64 0.71 0.89 0.79 1.17 0.48 0.96 1.27 1.30 0.76 0.74 1.17 0.85 0.73 1.10 1.18 0.96 1.17 1.02 0.98
ACCEPTED MANUSCRIPT
150.999 151.146 138.572 199.444 140.642 134.394 176.484 100.654 298.798 173.833 163.463 214.47 122.462 120.803 199.832 87.8692 217.821 143.191 129.34 134.326 142.176 214.287 163.954 150.023 205.134 257.219 145.997 258.561 162.486 110.971 227.022 231.245 294.752 42.1021 52.905 50.7711 41.4124 66.4355 37.6802 81.211 49.1506 56.0379 60.9577 10.942 43.5787 74.1725 55.1563 89.7464 15.5924 65.0486 77.5169 76.1826 70.4816 76.6657 55.0244 56.4139 249.32 70.0003 72.827 33.2513 69.5074 118.389
96.5095 118.976 141.334 184.869 134.798 106.808 174.676 54.9844 280.425 112.894 148.34 184.864 103.117 45.7544 207.779 54.2372 182.196 99.2238 137.646 126.416 106.095 156.53 110.725 98.8423 155.333 177.627 73.1054 117.262 176.439 69.431 115.376 93.2409 136.322 168.166 226.203 143.683 119.83 149.577 116.245 97.9356 78.8973 112.801 129.083 31.1147 123.583 166.128 108.929 151.501 35.2287 241.468 155.277 155.214 75.8418 162.673 94.2495 124.544 513.465 144.875 139.09 62.0181 162.753 262.961
RI PT
184.253 133.652 173.504 196.285 144.058 112.533 182.797 128.99 369.909 115.359 168.316 186.368 117.734 46.3485 248.463 110.98 217.178 96.0629 166.698 178.122 124.24 216.192 190.974 173.998 341.49 304.182 142.81 219.795 259.618 104.989 331.835 261.217 248.273 44.9139 69.0753 42.9761 46.1868 26.8944 54.8877 52.75 55.9465 42.8985 55.7844 16.3633 35.0756 88.0091 48.0402 72.5215 21.485 129.317 70.2717 93.0771 32.1368 75.976 54.1844 66.6667 226.33 77.4168 79.5119 37.2385 93.5414 148.893
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
TE D
Znf706 Mdm2 Ankzf1 Tmem14c Polr2g Zfand5 Nudt17 Casp6 Rsrc2 Cmbl Ap2s1 Gnb1 Mtatp8 Rtn4 Elp2 Bnip3l Akr7a2 Ifi30 Fntb Slc35e3 Crip1 Serpina3g Akr1c13 Tagln Ncam1 H2afx Anpep Sap18 Tmem176b Fdft1 Cxcl12 Ptgs1 Des Fads2 Gstm7 Sqle Prodh Hba Ca13 Mettl15 Apoa1 Apoo S100g Dock5 Surf6 Rala Ptgis F11r Sfxn2 Slc5a6
ORNT1_MOUSE Mitochondrial ornithine transporter 1 RTF2_MOUSE Protein RTF2 homolog NPS3B_MOUSE Protein NipSnap homolog 3B GCC2_MOUSE GRIP and coiled-coil domain-containing protein 2 CCD22_MOUSE Coiled-coil domain-containing protein 22 ARHG7_MOUSE Rho guanine nucleotide exchange factor 7 FCGRN_MOUSE IgG receptor FcRn large subunit p51 NU1M_MOUSE NADH-ubiquinone oxidoreductase chain 1 BPNT1_MOUSE 3'(2'),5'-bisphosphate nucleotidase 1 CACO1_MOUSE Calcium-binding and coiled-coil domain-containing protein 1 S100B_MOUSE Protein S100-B CR025_MOUSE Uncharacterized protein C18orf25 homolog ZN706_MOUSE Zinc finger protein 706 MDM2_MOUSE E3 ubiquitin-protein ligase Mdm2 ANKZ1_MOUSE Ankyrin repeat and zinc finger domain-containing protein 1 TM14C_MOUSE Transmembrane protein 14C RPB7_MOUSE DNA-directed RNA polymerase II subunit RPB7 ZFAN5_MOUSE AN1-type zinc finger protein 5 NUD17_MOUSE Nucleoside diphosphate-linked moiety X motif 17 CASP6_MOUSE Caspase-6 RSRC2_MOUSE Arginine/serine-rich coiled-coil protein 2 CMBL_MOUSE Carboxymethylenebutenolidase homolog AP2S1_MOUSE AP-2 complex subunit sigma GBB1_MOUSE Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 ATP8_MOUSE ATP synthase protein 8 RTN4_MOUSE Isoform 3 of Reticulon-4 ELP2_MOUSE Elongator complex protein 2 BNI3L_MOUSE BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like ARK72_MOUSE Aflatoxin B1 aldehyde reductase member 2 GILT_MOUSE Gamma-interferon-inducible lysosomal thiol reductase FNTB_MOUSE Protein farnesyltransferase subunit beta S35E3_MOUSE Solute carrier family 35 member E3 CRIP1_MOUSE Cysteine-rich protein 1 SPA3G_MOUSE Serine protease inhibitor A3G AK1CD_MOUSE Aldo-keto reductase family 1 member C13 TAGL_MOUSE Transgelin NCAM1_MOUSE Neural cell adhesion molecule 1 H2AX_MOUSE Histone H2AX AMPN_MOUSE Aminopeptidase N SAP18_MOUSE Histone deacetylase complex subunit SAP18 T176B_MOUSE Transmembrane protein 176B FDFT_MOUSE Squalene synthase SDF1_MOUSE Stromal cell-derived factor 1 PGH1_MOUSE Prostaglandin G/H synthase 1 DESM_MOUSE Desmin FADS2_MOUSE Fatty acid desaturase 2 GSTM7_MOUSE Glutathione S-transferase Mu 7 ERG1_MOUSE Squalene monooxygenase PROD_MOUSE Proline dehydrogenase 1, mitochondrial HBA_MOUSE Hemoglobin subunit alpha CAH13_MOUSE Carbonic anhydrase 13 MET15_MOUSE Probable methyltransferase-like protein 15 APOA1_MOUSE Apolipoprotein A-I APOO_MOUSE Apolipoprotein O S100G_MOUSE Protein S100-G DOCK5_MOUSE Dedicator of cytokinesis protein 5 SURF6_MOUSE Surfeit locus protein 6 RALA_MOUSE Ras-related protein Ral-A PTGIS_MOUSE Prostacyclin synthase JAM1_MOUSE Junctional adhesion molecule A SFXN2_MOUSE Sideroflexin-2 SC5A6_MOUSE Sodium-dependent multivitamin transporter
EP
Slc25a15 Rtfdc1 Nipsnap3b Gcc2 Ccdc22 Arhgef7 Fcgrt Mtnd1 Bpnt1 Calcoco1 S100b
AC C
sp|Q9WVD5|ORNT1_MOUSE sp|Q99K95|RTF2_MOUSE sp|Q9CQE1|NPS3B_MOUSE sp|Q8CHG3|GCC2_MOUSE sp|Q9JIG7|CCD22_MOUSE sp|Q9ES28|ARHG7_MOUSE sp|Q61559|FCGRN_MOUSE sp|P03888|NU1M_MOUSE sp|Q9Z0S1|BPNT1_MOUSE sp|Q8CGU1|CACO1_MOUSE sp|P50114|S100B_MOUSE sp|Q8BH50|CR025_MOUSE sp|Q9D115|ZN706_MOUSE sp|P23804|MDM2_MOUSE sp|Q80UU1|ANKZ1_MOUSE sp|Q9CQN6|TM14C_MOUSE sp|P62488|RPB7_MOUSE sp|O88878|ZFAN5_MOUSE sp|Q9CWD3|NUD17_MOUSE sp|O08738|CASP6_MOUSE sp|A2RTL5|RSRC2_MOUSE sp|Q8R1G2|CMBL_MOUSE sp|P62743|AP2S1_MOUSE sp|P62874|GBB1_MOUSE sp|P03930|ATP8_MOUSE sp|Q99P72-1|RTN4_MOUSE sp|Q91WG4|ELP2_MOUSE sp|Q9Z2F7|BNI3L_MOUSE sp|Q8CG76|ARK72_MOUSE sp|Q9ESY9|GILT_MOUSE sp|Q8K2I1|FNTB_MOUSE sp|Q6PGC7|S35E3_MOUSE sp|P63254|CRIP1_MOUSE sp|Q5I2A0|SPA3G_MOUSE sp|Q8VC28|AK1CD_MOUSE sp|P37804|TAGL_MOUSE sp|P13595|NCAM1_MOUSE sp|P27661|H2AX_MOUSE sp|P97449|AMPN_MOUSE sp|O55128|SAP18_MOUSE sp|Q9R1Q6|T176B_MOUSE sp|P53798|FDFT_MOUSE sp|P40224|SDF1_MOUSE sp|P22437|PGH1_MOUSE sp|P31001|DESM_MOUSE sp|Q9Z0R9|FADS2_MOUSE sp|Q80W21|GSTM7_MOUSE sp|P52019|ERG1_MOUSE sp|Q9WU79|PROD_MOUSE sp|P01942|HBA_MOUSE sp|Q9D6N1|CAH13_MOUSE sp|Q9DCL4|MET15_MOUSE sp|Q00623|APOA1_MOUSE sp|Q9DCZ4|APOO_MOUSE sp|P97816|S100G_MOUSE sp|B2RY04|DOCK5_MOUSE sp|P70279|SURF6_MOUSE sp|P63321|RALA_MOUSE sp|O35074|PTGIS_MOUSE sp|O88792|JAM1_MOUSE sp|Q925N2|SFXN2_MOUSE sp|Q5U4D8|SC5A6_MOUSE
191.385 125.573 126.288 154.241 108.475 104.024 131.327 139.29 284.977 131.045 130.476 145.039 93.8605 90.813 157.518 106.052 165.041 89.831 95.8979 114.633 99.0116 174.249 160.198 146.268 250.105 223.943 130.461 218.839 108.63 72.2107 219.504 192.802 128.6 191.496 173.587 130.452 105.943 83.9281 104.961 205.574 157.044 106.587 119.826 27.0812 34.478 158.501 91.2205 154.86 34.5698 123.821 118.563 137.274 100.931 97.7687 89.8571 81.5981 282.029 101.192 114.695 53.7171 104.062 174.354
165.373 189.338 142.919 190.801 122.132 162.04 143.336 86.8294 476.226 156.05 84.9687 62.7784 177.068 330.76 219.036 85.6156 164.614 28.9381 64.8074 185.856 115.359 159.967 139.313 417.536 115.879 104.547 105.055 152.508 124.966 37.417 200.492 326.642 69.099 197.616 80.387 87.1766 56.5573 122.765 72.4036 99.6836 78.6345 22.0961 59.2162 113.586 83.2383 48.4315 39.2007 57.7792 239.06 24.4348 104.444 140.595 75.2308 95.0268 33.1845 70.695 258.118 113.764 61.5347 55.2396 62.7413 186.529
126.874 325.34 108.979 287.693 189.797 200.015 150.181 79.1105 638.006 311.941 151.182 189.9 390.503 951.828 276.469 74.2449 168.4 106.055 126.691 136.451 194.522 353.574 136.232 530.383 180.753 238.689 88.5007 167.459 217.87 26.8235 188.895 508.292 107.331 362.742 96.9417 82.2449 29.9869 46.389 53.1126 131.345 97.0889 31.7808 73.0285 67.8788 168.59 67.706 56.4475 63.4875 366.35 16.355 169.447 107.351 128.698 53.2259 165.271 55.4139 231.066 67.5299 54.3968 26.8219 427.001 136.502
0.86 0.86 0.86 0.86 0.85 0.85 0.85 0.85 0.85 0.84 0.84 0.82 0.82 0.82 0.81 0.81 0.80 0.79 0.79 0.77 0.77 0.77 0.76 0.76 0.74 0.72 0.70 0.70 0.68 0.66 0.60 0.58 0.49 4.13 3.28 2.92 2.58 2.50 2.39 2.27 2.24 2.22 2.13 2.13 2.01 2.00 1.94 1.89 1.88 1.88 1.85 1.73 1.72 1.71 1.69 1.67 1.67 1.67 1.67 1.64 1.64 1.64
0.87 1.81 0.81 1.21 1.10 1.47 0.82 0.72 1.67 1.62 0.71 0.63 2.36 7.67 1.11 0.80 0.77 0.56 0.65 1.03 1.16 1.19 0.78 2.93 0.54 0.61 0.67 0.67 0.81 0.30 0.70 1.70 0.32 6.44 1.45 1.81 0.99 1.81 1.36 1.72 1.67 0.54 1.13 6.65 3.20 0.72 0.93 0.75 16.33 0.21 1.85 1.46 1.99 0.97 1.82 1.02 1.03 1.23 0.76 1.16 3.00 1.21
ACCEPTED MANUSCRIPT
TE D
121.68 49.3094 10.961 55.7648 91.2885 45.6625 175.282 48.4484 141.987 39.5705 58.6878 173.694 41.2357 57.03 58.0183 84.2438 83.4294 37.8897 65.4432 44.07 53.6905 52.4578 63.7224 158.993 82.2576 54.56 79.8284 143.672 79.3405 79.8107 37.3413 39.0387 39.6939 50.3419 78.1913 28.6757 111.809 77.1667 46.2351 100.38 32.3686 119.663 95.3409 63.9309 116.419 121.601 140.863 124.911 158.637 79.232 56.8613 131.908 44.6546 85.8093 97.9978 120.971 65.9903 93.0916 72.0716 67.7667 95.4787 96.3646
230.507 100.477 21.5423 94.7517 170.048 84.6007 269.726 87.0926 214.847 73.8362 106.829 307.572 68.132 117.819 115.433 157.969 143.659 60.9208 136.323 78.411 144.781 102.712 151.094 87.1508 160.22 89.5424 140.582 210.748 152.463 168.258 75.5975 53.0938 92.4534 108.75 105.017 55.959 140.794 119.286 72.9034 200.059 71.7395 198.452 183.334 106.108 181.675 173.945 247.304 216.962 300.079 134.758 95.5992 189.983 72.5191 159.007 142.851 138.54 102.368 172.564 115.091 118.043 160.514 144.481
RI PT
124.604 57.6613 11.2367 55.8848 81.1471 54.1108 109.971 52.206 139.842 37.5392 57.2642 185.785 44.0187 81.2863 76.2346 78.19 86.5882 41.7452 83.6895 48.5734 90.8778 66.8848 77.3522 94.087 97.6066 55.3176 82.634 137.089 91.4711 114.054 53.2245 21.0574 66.1632 76.5022 80.8847 36.9007 132.873 89.6091 55.4764 124.898 50.0086 129.346 116.72 56.408 106.818 119.888 161.178 140.545 206.011 91.3002 55.6507 108.763 52.2565 111.582 72.2614 112.506 69.2346 147.227 80.2338 76.486 107.475 94.2798
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
ABHD6_MOUSE Monoacylglycerol lipase ABHD6 MP2K3_MOUSE Dual specificity mitogen-activated protein kinase kinase 3 RAB21_MOUSE Ras-related protein Rab-21 CAN5_MOUSE Calpain-5 TIM14_MOUSE Mitochondrial import inner membrane translocase subunit TIM14 CMC2_MOUSE Calcium-binding mitochondrial carrier protein Aralar2 CC134_MOUSE Coiled-coil domain-containing protein 134 MFGM_MOUSE Lactadherin IRGM1_MOUSE Immunity-related GTPase family M protein 1 RU2B_MOUSE U2 small nuclear ribonucleoprotein B'' SHOC2_MOUSE Leucine-rich repeat protein SHOC-2 IF4G3_MOUSE Eukaryotic translation initiation factor 4 gamma 3 HTR5A_MOUSE HEAT repeat-containing protein 5A C1GLT_MOUSE Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 UB2J1_MOUSE Ubiquitin-conjugating enzyme E2 J1 F8VPP8_MOUSE Protein Zc3h7b ITPR3_MOUSE Inositol 1,4,5-trisphosphate receptor type 3 MPC1_MOUSE Mitochondrial pyruvate carrier 1 TI17B_MOUSE Mitochondrial import inner membrane translocase subunit Tim17-B STXB1_MOUSE Syntaxin-binding protein 1 COL12_MOUSE Collectin-12 ANR46_MOUSE Ankyrin repeat domain-containing protein 46 AHSA2_MOUSE Activator of 90 kDa heat shock protein ATPase homolog 2 ATIF1_MOUSE ATPase inhibitor, mitochondrial A2AT37_MOUSE Protein Upf2 TSC2_MOUSE Tuberin RAB31_MOUSE Ras-related protein Rab-31 RDH11_MOUSE Retinol dehydrogenase 11 TPSN_MOUSE Tapasin SFXN5_MOUSE Sideroflexin-5 SIK3_MOUSE Serine/threonine-protein kinase SIK3 TIM16_MOUSE Mitochondrial import inner membrane translocase subunit TIM16 RFC1_MOUSE Replication factor C subunit 1 RT33_MOUSE 28S ribosomal protein S33, mitochondrial F115A_MOUSE Protein FAM115A SUV3_MOUSE ATP-dependent RNA helicase SUPV3L1, mitochondrial FADS3_MOUSE Fatty acid desaturase 3 DJC16_MOUSE DnaJ homolog subfamily C member 16 EHBP1_MOUSE EH domain-binding protein 1 NDUB5_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial WDR46_MOUSE WD repeat-containing protein 46 FMNL2_MOUSE Formin-like protein 2 CADH2_MOUSE Cadherin-2 LYRM5_MOUSE LYR motif-containing protein 5 NDUAD_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NOC2L_MOUSE Nucleolar complex protein 2 homolog LYRM2_MOUSE LYR motif-containing protein 2 ARHGA_MOUSE Rho guanine nucleotide exchange factor 10 E9Q166_MOUSE Protein Atad2b SNTB2_MOUSE Beta-2-syntrophin GNA1_MOUSE Glucosamine 6-phosphate N-acetyltransferase TAM41_MOUSE Mitochondrial translocator assembly and maintenance protein 41 homolog NOP10_MOUSE H/ACA ribonucleoprotein complex subunit 3 SYTC2_MOUSE Probable threonine--tRNA ligase 2, cytoplasmic NDUF6_MOUSE NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 TV23B_MOUSE Golgi apparatus membrane protein TVP23 homolog B HEG1_MOUSE Protein HEG homolog 1 ADH7_MOUSE Alcohol dehydrogenase class 4 mu/sigma chain ARHGC_MOUSE Rho guanine nucleotide exchange factor 12 RCAS1_MOUSE Receptor-binding cancer antigen expressed on SiSo cells LCLT1_MOUSE Lysocardiolipin acyltransferase 1 SUN2_MOUSE SUN domain-containing protein 2
EP
Abhd6 Map2k3 Rab21 Capn5 Dnajc19 Slc25a13 Ccdc134 Mfge8 Irgm1 Snrpb2 Shoc2 Eif4g3 Heatr5a C1galt1 Ube2j1 Zc3h7b Itpr3 Mpc1 Timm17b Stxbp1 Colec12 Ankrd46 Ahsa2 Atpif1 Upf2 Tsc2 Rab31 Rdh11 Tapbp Sfxn5 Sik3 Pam16 Rfc1 Mrps33 Fam115a Supv3l1 Fads3 Dnajc16 Ehbp1 Ndufb5 Wdr46 Fmnl2 Cdh2 Lyrm5 Ndufa13 Noc2l Lyrm2 Arhgef10 Atad2b Sntb2 Gnpnat1 Tamm41 Nop10 Tarsl2 Ndufaf6 Tvp23b Heg1 Adh7 Arhgef12 Ebag9 Lclat1 Sun2
AC C
sp|Q8R2Y0|ABHD6_MOUSE sp|O09110|MP2K3_MOUSE sp|P35282|RAB21_MOUSE sp|O08688|CAN5_MOUSE sp|Q9CQV7|TIM14_MOUSE sp|Q9QXX4|CMC2_MOUSE sp|Q8C7V8|CC134_MOUSE sp|P21956|MFGM_MOUSE sp|Q60766|IRGM1_MOUSE sp|Q9CQI7|RU2B_MOUSE sp|O88520|SHOC2_MOUSE sp|Q80XI3|IF4G3_MOUSE sp|Q5PRF0|HTR5A_MOUSE sp|Q9JJ06|C1GLT_MOUSE sp|Q9JJZ4|UB2J1_MOUSE tr|F8VPP8|F8VPP8_MOUSE sp|P70227|ITPR3_MOUSE sp|P63030|MPC1_MOUSE sp|Q9Z0V7|TI17B_MOUSE sp|O08599|STXB1_MOUSE sp|Q8K4Q8|COL12_MOUSE sp|Q8BTZ5|ANR46_MOUSE sp|Q8N9S3|AHSA2_MOUSE sp|O35143|ATIF1_MOUSE tr|A2AT37|A2AT37_MOUSE sp|Q61037|TSC2_MOUSE sp|Q921E2|RAB31_MOUSE sp|Q9QYF1|RDH11_MOUSE sp|Q9R233|TPSN_MOUSE sp|Q925N0|SFXN5_MOUSE sp|Q6P4S6|SIK3_MOUSE sp|Q9CQV1|TIM16_MOUSE sp|P35601|RFC1_MOUSE sp|Q9D2R8|RT33_MOUSE sp|Q8BNE1|F115A_MOUSE sp|Q80YD1|SUV3_MOUSE sp|Q9JJE7|FADS3_MOUSE sp|Q80TN4|DJC16_MOUSE sp|Q69ZW3|EHBP1_MOUSE sp|Q9CQH3|NDUB5_MOUSE sp|Q9Z0H1|WDR46_MOUSE sp|A2APV2|FMNL2_MOUSE sp|P15116|CADH2_MOUSE sp|Q91V16|LYRM5_MOUSE sp|Q9ERS2|NDUAD_MOUSE sp|Q9WV70|NOC2L_MOUSE sp|Q8R033|LYRM2_MOUSE sp|Q8C033|ARHGA_MOUSE tr|E9Q166|E9Q166_MOUSE sp|Q61235|SNTB2_MOUSE sp|Q9JK38|GNA1_MOUSE sp|Q3TUH1|TAM41_MOUSE sp|Q9CQS2|NOP10_MOUSE sp|Q8BLY2|SYTC2_MOUSE sp|A2AIL4|NDUF6_MOUSE sp|Q9D8T4|TV23B_MOUSE sp|E9Q7X6|HEG1_MOUSE sp|Q64437|ADH7_MOUSE sp|Q8R4H2|ARHGC_MOUSE sp|Q9D0V7|RCAS1_MOUSE sp|Q3UN02|LCLT1_MOUSE sp|Q8BJS4|SUN2_MOUSE
169.202 71.589 14.0352 83.489 101.576 72.1457 177.534 70.7108 225.98 46.6688 73.716 249.081 63.8753 96.0633 91.2948 91.7057 117.637 59.7599 89.0394 61.4124 73.0449 76.7784 60.7569 291.122 107.599 73.0769 99.7585 203.508 99.1649 115.808 57.1035 34.9031 61.9412 76.1509 126.562 39.4261 214.19 121.774 74.0107 124.804 46.8699 157.478 119.196 65.2298 135.917 167.145 177.193 155.954 210.745 103.291 60.7501 143.887 60.3927 110.212 89.2754 179.013 81.4815 152.752 90.632 76.4276 112.317 111.355
147.205 203.716 587.425 97.1127 114.794 88.6514 207.27 68.9007 124.796 57.7667 150.927 235.867 81.9742 105.509 82.8942 45.8345 213.811 49.6597 114.948 108.785 36.8802 81.8764 75.1507 128.098 113.783 67.2868 177.497 181.505 63.9411 88.8183 60.7273 30.5816 42.6175 25.4304 129.781 51.3458 59.7134 109.681 60.0086 104.515 80.245 182.353 115.897 41.7356 132.088 182.075 98.625 102.425 75.3817 82.0681 95.792 134.766 47.319 125.885 91.779 166.253 117.298 119.154 100.633 72.0297 116.594 146.396
208.402 146.438 387.561 58.2826 107.124 40.4834 196.792 65.1945 87.2387 61.375 117.577 259.734 42.5653 72.28 130.127 167.732 134.227 18.8968 58.1247 52.2347 33.2739 102.29 79.9264 174.146 102.705 80.4452 130.93 128.303 65.7666 82.0994 62.3139 60.8524 68.2265 39.7708 93.0967 146.493 93.4668 91.6978 123.793 86.929 49.0799 102.426 103.67 74.5162 135.815 100.035 104.275 60.3786 75.2922 68.3856 89.6413 171.717 37.8653 103.583 93.605 88.5385 85.7551 64.4189 213.115 56.2693 87.4263 125.895
1.62 1.61 1.60 1.60 1.58 1.57 1.57 1.57 1.56 1.56 1.56 1.55 1.55 1.55 1.54 1.54 1.54 1.52 1.51 1.51 1.51 1.50 1.50 1.49 1.49 1.48 1.48 1.48 1.47 1.47 1.47 1.46 1.46 1.46 1.46 1.45 1.45 1.45 1.44 1.44 1.44 1.43 1.43 1.42 1.42 1.41 1.41 1.40 1.40 1.40 1.39 1.39 1.37 1.36 1.36 1.36 1.36 1.35 1.35 1.35 1.34 1.34
1.44 3.27 43.92 1.39 1.29 1.29 1.42 1.33 0.75 1.55 2.32 1.38 1.46 1.29 1.59 1.31 2.05 0.86 1.16 1.74 0.49 1.54 1.10 1.19 1.20 1.34 1.90 1.10 0.76 0.88 1.36 1.52 1.05 0.51 1.40 3.02 0.63 1.21 1.81 0.85 1.57 1.14 1.04 0.97 1.20 1.17 0.67 0.61 0.41 0.88 1.65 1.27 0.88 1.16 1.09 1.09 1.50 0.76 2.06 0.89 1.01 1.43
ACCEPTED MANUSCRIPT
59.3731 76.5677 162.106 49.6614 165.376 146.204 57.3368 126.67 64.7694 129.916 47.3269 111.749 316.599 164.759 85.1746 111.08 140.199 90.8927 97.9944 34.8447 62.6217 49.474 45.6137 50.7585 81.9116 90.4791 60.7991 62.4375 83.5623 95.7571 78.421 133.666 57.7171 58.853 72.4537 88.4601 154.976 115.152 131.124 70.0327 235.336 126.924 43.4262 180.521 178.016 53.5888 85.8475 64.1421 54.537 63.4732 65.3268 101.64 72.7402 69.248 36.1294 69.8427 84.7318 109.733 40.4733 106.353 96.673 75.1883
80.1222 91.1366 156.03 89.3166 238.993 213.465 106.278 193.616 79.5289 213.393 68.8336 167.355 229.248 243.549 134.753 198.394 197.876 116.344 156.717 67.2345 87.7088 67.7188 80.8004 65.1449 101.313 124.621 57.2556 90.9563 109.66 156.214 135.166 206.514 93.6274 94.7765 96.0564 126.591 233.194 152.143 175.131 91.7562 278.598 141.3 74.6608 256.922 227.391 77.9854 152.477 94.2562 84.3576 93.2548 47.9623 139.656 107.193 65.7533 60.3744 77.0363 117.144 166.284 59.7457 119.888 143.946 105.586
RI PT
64.9103 59.3943 150.812 64.6449 153.689 154.865 68.9912 121.79 45.8846 146.912 40.1805 129.019 121.339 168.406 88.723 142.7 136.743 86.2042 111.114 49.7377 77.1808 55.4913 61.7547 43.4908 78.3799 76.8518 44.9552 68.642 65.6777 122.452 103.677 136.739 61.464 77.666 68.5211 95.0197 162.176 116.984 159.391 70.4958 227.022 107.747 57.025 182.16 184.589 49.1171 114.184 78.1491 61.1894 63.1411 53.1312 104.026 73.9979 56.4446 48.3258 48.3582 90.5231 125.787 40.631 92.5691 112.161 80.7729
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
TE D
FMO2_MOUSE Dimethylaniline monooxygenase [N-oxide-forming] 2 FSTL1_MOUSE Follistatin-related protein 1 G3X9B1_MOUSE HEAT repeat containing 1 DI3L2_MOUSE DIS3-like exonuclease 2 CCD91_MOUSE Coiled-coil domain-containing protein 91 MSRB2_MOUSE Methionine-R-sulfoxide reductase B2, mitochondrial DCAF6_MOUSE DDB1- and CUL4-associated factor 6 CDK9_MOUSE Cyclin-dependent kinase 9 CBP_MOUSE CREB-binding protein SCFD2_MOUSE Sec1 family domain-containing protein 2 ANKL2_MOUSE Ankyrin repeat and LEM domain-containing protein 2 FBX7_MOUSE F-box only protein 7 S2551_MOUSE Solute carrier family 25 member 51 PLXA1_MOUSE Plexin-A1 SENP7_MOUSE Sentrin-specific protease 7 GALT_MOUSE Galactose-1-phosphate uridylyltransferase ANT3_MOUSE Antithrombin-III TF_MOUSE Tissue factor ENPP4_MOUSE Bis(5'-adenosyl)-triphosphatase enpp4 PB1_MOUSE Protein polybromo-1 UTP20_MOUSE Small subunit processome component 20 homolog PNO1_MOUSE RNA-binding protein PNO1 BCS1_MOUSE Mitochondrial chaperone BCS1 CD81_MOUSE CD81 antigen ILKAP_MOUSE Integrin-linked kinase-associated serine/threonine phosphatase 2C SMUG1_MOUSE Single-strand selective monofunctional uracil DNA glycosylase SYNRG_MOUSE Synergin gamma CL16A_MOUSE Protein CLEC16A SYEM_MOUSE Probable glutamate--tRNA ligase, mitochondrial TM261_MOUSE Transmembrane protein 261 FACR1_MOUSE Fatty acyl-CoA reductase 1 TDRP_MOUSE Testis development-related protein RAB13_MOUSE Ras-related protein Rab-13 METL8_MOUSE Methyltransferase-like protein 8 UACA_MOUSE Uveal autoantigen with coiled-coil domains and ankyrin repeats SEC62_MOUSE Translocation protein SEC62 CISD2_MOUSE CDGSH iron-sulfur domain-containing protein 2 PSB10_MOUSE Proteasome subunit beta type-10 NCLN_MOUSE Nicalin S27A4_MOUSE Long-chain fatty acid transport protein 4 YKT6_MOUSE Synaptobrevin homolog YKT6 CLCC1_MOUSE Chloride channel CLIC-like protein 1 MTMR2_MOUSE Myotubularin-related protein 2 ARL15_MOUSE ADP-ribosylation factor-like protein 15 PSME4_MOUSE Proteasome activator complex subunit 4 HBS1L_MOUSE HBS1-like protein ZDHC5_MOUSE Palmitoyltransferase ZDHHC5 PP4R1_MOUSE Serine/threonine-protein phosphatase 4 regulatory subunit 1 ABD12_MOUSE Monoacylglycerol lipase ABHD12 VATD_MOUSE V-type proton ATPase subunit D HDHD3_MOUSE Haloacid dehalogenase-like hydrolase domain-containing protein 3 D3Z7X0_MOUSE MCG142036 DJB12_MOUSE DnaJ homolog subfamily B member 12 CE290_MOUSE Centrosomal protein of 290 kDa RM18_MOUSE 39S ribosomal protein L18, mitochondrial TOM7_MOUSE Mitochondrial import receptor subunit TOM7 homolog ITPR2_MOUSE Inositol 1,4,5-trisphosphate receptor type 2 DTX3L_MOUSE E3 ubiquitin-protein ligase DTX3L ARMC8_MOUSE Armadillo repeat-containing protein 8 KAD1_MOUSE Adenylate kinase isoenzyme 1 N4BP1_MOUSE NEDD4-binding protein 1 CUTC_MOUSE Copper homeostasis protein cutC homolog
EP
Fmo2 Fstl1 Heatr1 Dis3l2 Ccdc91 Msrb2 Dcaf6 Cdk9 Crebbp Scfd2 Ankle2 Fbxo7 Slc25a51 Plxna1 Senp7 Galt Serpinc1 F3 Enpp4 Pbrm1 Utp20 Pno1 Bcs1l Cd81 Ilkap Smug1 Synrg Clec16a Ears2 Tmem261 Far1 Tdrp Rab13 Mettl8 Uaca Sec62 Cisd2 Psmb10 Ncln Slc27a4 Ykt6 Clcc1 Mtmr2 Arl15 Psme4 Hbs1l Zdhhc5 Ppp4r1 Abhd12 Atp6v1d Hdhd3 Acad12 Dnajb12 Cep290 Mrpl18 Tomm7 Itpr2 Dtx3l Armc8 Ak1 N4bp1 Cutc
AC C
sp|Q8K2I3|FMO2_MOUSE sp|Q62356|FSTL1_MOUSE tr|G3X9B1|G3X9B1_MOUSE sp|Q8CI75|DI3L2_MOUSE sp|Q9D8L5|CCD91_MOUSE sp|Q78J03|MSRB2_MOUSE sp|Q9DC22|DCAF6_MOUSE sp|Q99J95|CDK9_MOUSE sp|P45481|CBP_MOUSE sp|Q8BTY8|SCFD2_MOUSE sp|Q6P1H6|ANKL2_MOUSE sp|Q3U7U3|FBX7_MOUSE sp|Q5HZI9|S2551_MOUSE sp|P70206|PLXA1_MOUSE sp|Q8BUH8|SENP7_MOUSE sp|Q03249|GALT_MOUSE sp|P32261|ANT3_MOUSE sp|P20352|TF_MOUSE sp|Q8BTJ4|ENPP4_MOUSE sp|Q8BSQ9|PB1_MOUSE sp|Q5XG71|UTP20_MOUSE sp|Q9CPS7|PNO1_MOUSE sp|Q9CZP5|BCS1_MOUSE sp|P35762|CD81_MOUSE sp|Q8R0F6|ILKAP_MOUSE sp|Q6P5C5|SMUG1_MOUSE sp|Q5SV85|SYNRG_MOUSE sp|Q80U30|CL16A_MOUSE sp|Q9CXJ1|SYEM_MOUSE sp|Q9CQ00|TM261_MOUSE sp|Q922J9|FACR1_MOUSE sp|Q8C5P7|TDRP_MOUSE sp|Q9DD03|RAB13_MOUSE sp|A2AUU0|METL8_MOUSE sp|Q8CGB3|UACA_MOUSE sp|Q8BU14|SEC62_MOUSE sp|Q9CQB5|CISD2_MOUSE sp|O35955|PSB10_MOUSE sp|Q8VCM8|NCLN_MOUSE sp|Q91VE0|S27A4_MOUSE sp|Q9CQW1|YKT6_MOUSE sp|Q99LI2|CLCC1_MOUSE sp|Q9Z2D1|MTMR2_MOUSE sp|Q8BGR6|ARL15_MOUSE sp|Q5SSW2|PSME4_MOUSE sp|Q69ZS7|HBS1L_MOUSE sp|Q8VDZ4|ZDHC5_MOUSE sp|Q8K2V1|PP4R1_MOUSE sp|Q99LR1|ABD12_MOUSE sp|P57746|VATD_MOUSE sp|Q9CYW4|HDHD3_MOUSE tr|D3Z7X0|D3Z7X0_MOUSE sp|Q9QYI4|DJB12_MOUSE sp|Q6A078|CE290_MOUSE sp|Q9CQL5|RM18_MOUSE sp|Q9D173|TOM7_MOUSE sp|Q9Z329|ITPR2_MOUSE sp|Q3UIR3|DTX3L_MOUSE sp|Q9DBR3|ARMC8_MOUSE sp|Q9R0Y5|KAD1_MOUSE sp|Q6A037|N4BP1_MOUSE sp|Q9D8X1|CUTC_MOUSE
86.1449 90.5283 261.565 63.008 186.149 187.677 61.731 136.308 67.3492 153.747 47.0858 151.486 350.537 195.499 94.0974 135.537 166.477 116.162 116.196 43.1326 94.4062 68.9543 58.9875 57.3912 106.915 92.4761 79.9107 78.8383 83.6111 125.642 100.033 142.356 59.9756 81.1567 85.4154 109.305 174.068 145.807 197.643 88.523 313.832 158.959 53.7593 205.894 235.055 52.8652 102.225 86.8581 62.6733 67.3204 102.14 120.479 78.2174 92.8911 46.2075 71.9236 103.079 129.631 42.1316 129.549 117.784 89.5066
45.3837 43.1118 271.553 68.2433 132.878 31.2113 53.6604 121.494 150.141 166.978 52.7292 119.411 124.09 252.934 41.8466 104.082 239.029 70.7132 78.3033 128.801 106.399 56.1405 45.9431 55.4351 370.041 105.27 103.362 61.9018 34.6541 140.752 80.8684 49.7514 46.4177 35.1862 92.6864 177.366 157.558 53.0511 201.897 86.2362 241.158 37.3391 33.1884 168.249 213.266 52.9756 82.0759 92.3019 45.8742 86.4997 43.759 55.4151 84.4128 473.879 25.9031 154.529 194.731 125.295 38.9342 113.885 84.6444 82.7653
99.1153 89.4081 141.932 113.873 350.604 158.233 90.739 112.895 391.282 113.655 112.77 84.7202 187.866 179.931 90.0637 159.194 246.112 59.5147 90.1485 99.0829 66.9725 44.8303 24.8766 34.5822 533.311 152.98 89.5965 36.4073 74.162 88.0827 191.135 195.504 28.9786 64.9823 103.297 164.136 137.97 121.802 118.715 56.2148 161.436 18.9916 32.8371 225.573 181.16 50.348 82.8072 139.801 47.213 70.516 74.1526 69.1664 77.6585 291.096 34.43 80.4865 177.015 189.968 30.1214 169.02 132.288 120.18
1.34 1.34 1.33 1.33 1.33 1.33 1.33 1.33 1.33 1.33 1.32 1.32 1.32 1.32 1.32 1.32 1.32 1.31 1.31 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.29 1.29 1.29 1.29 1.29 1.29 1.29 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.27 1.27 1.27 1.27 1.27 1.27 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.25 1.25 1.25
1.16 0.97 1.32 1.59 1.52 0.63 1.14 0.94 4.89 1.01 1.89 0.85 0.71 1.30 0.76 1.04 1.75 0.74 0.81 2.69 1.24 0.96 0.66 0.96 5.64 1.54 1.82 0.75 0.73 1.05 1.49 0.91 0.63 0.73 1.39 1.86 0.93 0.75 1.10 1.01 0.87 0.24 0.66 1.09 1.09 1.01 0.82 1.63 0.80 1.24 1.00 0.61 1.10 6.09 0.71 1.99 2.12 1.34 0.85 1.42 1.04 1.30
ACCEPTED MANUSCRIPT
TE D
83.4032 42.0716 63.7494 128.465 72.0462 60.5767 75.3963 126.567 77.5802 129.136 79.4935 98.1082 63.4026 60.9256 74.5944 134.027 85.3341 95.2333 139.274 96.0023 57.2844 73.95 104.486 67.5962 133.83 81.5952 57.0243 93.7554 85.833 31.6073 157.023 86.9024 91.3594 96.573 159.961 95.5324 33.1631 164.813 64.0109 83.6375 77.5576 96.9583 72.8676 45.92 72.3358 77.3723 153.708 85.0247 44.1677 48.3311 91.6991 262.598 92.9035 118.188 108.11 60.359 40.1937 66.7157 61.9579 93.3023 79.1595 55.9961
121.969 63.7935 79.7405 202.841 112.321 71.7291 105.101 164.604 86.3572 207.45 124.029 156.534 85.4736 76.9006 88.6463 118.984 115.79 142.908 188.073 128.686 89.4639 61.4905 153.206 83.0421 154.998 108.199 100.154 131.475 132.536 49.2367 231.817 122.167 129.7 145.293 141.938 125.175 39.9613 234.348 59.9642 95.5855 94.2251 140.263 96.0296 54.3824 112.703 101.687 206.517 111.989 59.8007 73.0248 143.9 360.804 142.988 138.858 156.42 90.9412 62.9737 76.786 93.3463 130.058 113.477 59.6881
RI PT
88.1002 53.48 56.3378 133.083 79.4553 65.915 75.2587 126.932 58.375 151.913 92.5686 112.108 67.0712 61.1345 58.0436 114.115 88.0387 110.231 145.595 94.4875 68.3587 51.5864 128.243 59.6852 112.768 78.4769 77.1345 108.906 106.274 38.7568 168.422 113.843 99.6467 119.973 167.302 101.226 29.4528 183.553 51.2768 93.8342 84.348 89.9818 78.0973 41.7638 94.4825 87.9599 165.592 74.9375 53.4692 60.5567 116.995 260.185 118.868 136.954 134.386 75.1484 54.0069 60.6669 73.7315 108.621 96.9727 58.2427
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
XXLT1_MOUSE Xyloside xylosyltransferase 1 DIEXF_MOUSE Digestive organ expansion factor homolog CCNT1_MOUSE Cyclin-T1 MSS4_MOUSE Guanine nucleotide exchange factor MSS4 SARAF_MOUSE Store-operated calcium entry-associated regulatory factor DPEP1_MOUSE Dipeptidase 1 PGFS_MOUSE Prostamide/prostaglandin F synthase SIR5_MOUSE NAD-dependent protein deacylase sirtuin-5, mitochondrial PG12A_MOUSE Group XIIA secretory phospholipase A2 GCP2_MOUSE Gamma-tubulin complex component 2 CERU_MOUSE Ceruloplasmin DDX27_MOUSE Probable ATP-dependent RNA helicase DDX27 ADA10_MOUSE Disintegrin and metalloproteinase domain-containing protein 10 TRM2A_MOUSE tRNA (uracil-5-)-methyltransferase homolog A NOSIP_MOUSE Nitric oxide synthase-interacting protein RCL1_MOUSE RNA 3'-terminal phosphate cyclase-like protein UH1BL_MOUSE UHRF1-binding protein 1-like T126A_MOUSE Transmembrane protein 126A 2A5A_MOUSE Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform PRIO_MOUSE Major prion protein TAF6_MOUSE Transcription initiation factor TFIID subunit 6 COX19_MOUSE Cytochrome c oxidase assembly protein COX19 SPTB1_MOUSE Spectrin beta chain, erythrocytic VKGC_MOUSE Vitamin K-dependent gamma-carboxylase ZY11B_MOUSE Protein zyg-11 homolog B RM54_MOUSE 39S ribosomal protein L54, mitochondrial TRM1L_MOUSE TRMT1-like protein NUP85_MOUSE Nuclear pore complex protein Nup85 RFC2_MOUSE Replication factor C subunit 2 PGPI_MOUSE Pyroglutamyl-peptidase 1 GLCNE_MOUSE Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase RMD2_MOUSE Regulator of microtubule dynamics protein 2 PACS1_MOUSE Phosphofurin acidic cluster sorting protein 1 ACOT8_MOUSE Acyl-coenzyme A thioesterase 8 GALE_MOUSE UDP-glucose 4-epimerase RNF13_MOUSE E3 ubiquitin-protein ligase RNF13 KTI12_MOUSE Protein KTI12 homolog QRIC1_MOUSE Glutamine-rich protein 1 PSD10_MOUSE 26S proteasome non-ATPase regulatory subunit 10 LPP3_MOUSE Lipid phosphate phosphohydrolase 3 MOT1_MOUSE Monocarboxylate transporter 1 MED15_MOUSE Mediator of RNA polymerase II transcription subunit 15 TIF1A_MOUSE Transcription intermediary factor 1-alpha EXOS3_MOUSE Exosome complex component RRP40 C2D1B_MOUSE Coiled-coil and C2 domain-containing protein 1B PPARG_MOUSE Peroxisome proliferator-activated receptor gamma DEOC_MOUSE Putative deoxyribose-phosphate aldolase NECP1_MOUSE Adaptin ear-binding coat-associated protein 1 CCZ1_MOUSE Vacuolar fusion protein CCZ1 homolog RAB35_MOUSE Ras-related protein Rab-35 TOR2A_MOUSE Torsin-2A DOPD_MOUSE D-dopachrome decarboxylase RM48_MOUSE 39S ribosomal protein L48, mitochondrial COX14_MOUSE Cytochrome c oxidase assembly protein COX14 TRMB_MOUSE tRNA (guanine-N(7)-)-methyltransferase SELO_MOUSE Selenoprotein O WDR18_MOUSE WD repeat-containing protein 18 MOC2A_MOUSE Molybdopterin synthase sulfur carrier subunit SPG20_MOUSE Spartin PAFA2_MOUSE Platelet-activating factor acetylhydrolase 2, cytoplasmic KS6A1_MOUSE Ribosomal protein S6 kinase alpha-1 MSPD2_MOUSE Motile sperm domain-containing protein 2
EP
Xxylt1 Diexf Ccnt1 Rabif Tmem66 Dpep1 Fam213b Sirt5 Pla2g12a Tubgcp2 Cp Ddx27 Adam10 Trmt2a Nosip Rcl1 Uhrf1bp1l Tmem126a Ppp2r5a Prnp Taf6 Cox19 Sptb Ggcx Zyg11b Mrpl54 Trmt1l Nup85 Rfc2 Pgpep1 Gne Rmdn2 Pacs1 Acot8 Gale Rnf13 Kti12 Qrich1 Psmd10 Ppap2b Slc16a1 Med15 Trim24 Exosc3 Cc2d1b Pparg Dera Necap1 Ccz1 Rab35 Tor2a Ddt Mrpl48 Cox14 Mettl1 Selo Wdr18 Mocs2 Spg20 Pafah2 Rps6ka1 Mospd2
AC C
sp|Q3U4G3|XXLT1_MOUSE sp|Q8BTT6|DIEXF_MOUSE sp|Q9QWV9|CCNT1_MOUSE sp|Q91X96|MSS4_MOUSE sp|Q8R3Q0|SARAF_MOUSE sp|P31428|DPEP1_MOUSE sp|Q9DB60|PGFS_MOUSE sp|Q8K2C6|SIR5_MOUSE sp|Q9EPR2|PG12A_MOUSE sp|Q921G8|GCP2_MOUSE sp|Q61147|CERU_MOUSE sp|Q921N6|DDX27_MOUSE sp|O35598|ADA10_MOUSE sp|Q8BNV1|TRM2A_MOUSE sp|Q9D6T0|NOSIP_MOUSE sp|Q9JJT0|RCL1_MOUSE sp|A2RSJ4|UH1BL_MOUSE sp|Q9D8Y1|T126A_MOUSE sp|Q6PD03|2A5A_MOUSE sp|P04925|PRIO_MOUSE sp|Q62311|TAF6_MOUSE sp|Q8K0C8|COX19_MOUSE sp|P15508|SPTB1_MOUSE sp|Q9QYC7|VKGC_MOUSE sp|Q3UFS0|ZY11B_MOUSE sp|Q9CPW3|RM54_MOUSE sp|A2RSY6|TRM1L_MOUSE sp|Q8R480|NUP85_MOUSE sp|Q9WUK4|RFC2_MOUSE sp|Q9ESW8|PGPI_MOUSE sp|Q91WG8|GLCNE_MOUSE sp|Q8BSE0|RMD2_MOUSE sp|Q8K212|PACS1_MOUSE sp|P58137|ACOT8_MOUSE sp|Q8R059|GALE_MOUSE sp|O54965|RNF13_MOUSE sp|Q9D1R2|KTI12_MOUSE sp|Q3UA37|QRIC1_MOUSE sp|Q9Z2X2|PSD10_MOUSE sp|Q99JY8|LPP3_MOUSE sp|P53986|MOT1_MOUSE sp|Q924H2|MED15_MOUSE sp|Q64127|TIF1A_MOUSE sp|Q7TQK4|EXOS3_MOUSE sp|Q8BRN9|C2D1B_MOUSE sp|P37238|PPARG_MOUSE sp|Q91YP3|DEOC_MOUSE sp|Q9CR95|NECP1_MOUSE sp|Q8C1Y8|CCZ1_MOUSE sp|Q6PHN9|RAB35_MOUSE sp|Q8R1J9|TOR2A_MOUSE sp|O35215|DOPD_MOUSE sp|Q8JZS9|RM48_MOUSE sp|Q8BH51|COX14_MOUSE sp|Q9Z120|TRMB_MOUSE sp|Q9DBC0|SELO_MOUSE sp|Q4VBE8|WDR18_MOUSE sp|Q9Z224|MOC2A_MOUSE sp|Q8R1X6|SPG20_MOUSE sp|Q8VDG7|PAFA2_MOUSE sp|P18653|KS6A1_MOUSE sp|Q9CWP6|MSPD2_MOUSE
92.2703 55.5314 70.0465 123.067 76.3978 85.8288 82.3973 150.096 82.3142 141.129 89.0283 103.727 76.0587 74.1721 75.2848 187.542 98.0569 110.476 162.688 105.573 64.9763 92.7996 132.686 73.292 147.399 87.846 64.1172 116.235 102.209 36.5326 164.369 122.019 102.488 117.765 254.814 113.068 35.8441 187.337 79.5313 118.741 100.591 84.5127 85.4344 51.0102 87.6436 96.8135 176.695 79.9181 57.2561 57.3296 105.883 262.13 109.04 164.57 131.918 69.945 48.8628 74.0871 67.3439 108.921 94.5373 75.0724
58.7507 58.8253 95.7753 112.145 72.7384 24.263 133.989 95.19 75.9006 161.176 50.3514 156.784 77.2185 116.741 104.709 203.57 85.0291 144.889 125.895 113.204 61.1687 59.9173 131.175 113.217 186.833 23.9512 402.563 123.79 92.0153 59.8017 137.073 88.5615 121.091 175.436 135.28 76.7431 71.5607 164.002 72.6028 74.4669 148.094 96.8824 109.272 66.6284 65.9148 81.0973 198.796 83.4214 80.3057 97.3946 59.8449 223.343 43.6867 157.898 109.935 82.5632 51.5462 62.0745 94.0025 116.081 108.009 43.5783
82.1513 28.4215 158.203 178.417 77.4334 29.3183 250.953 249.789 151.064 138.878 80.4308 44.7378 111.28 116.546 234.699 107.108 132.968 100.266 94.9021 161.78 56.624 122.541 96.0901 100.503 107.589 105.066 378.389 80.5853 65.7119 52.4038 142.97 84.8002 98.9258 132.245 109.017 83.8131 221.339 142.787 149.099 62.7048 61.3969 239.088 224.642 36.4956 78.677 156.787 126.436 114.235 74.8014 111.957 72.3328 681.821 58.8238 193.007 76.9786 109.75 40.3809 211.756 133.279 88.0005 111.854 58.4684
1.25 1.25 1.25 1.25 1.25 1.25 1.24 1.24 1.24 1.24 1.24 1.24 1.24 1.24 1.24 1.24 1.23 1.23 1.23 1.23 1.23 1.23 1.23 1.23 1.23 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.21 1.21 1.21 1.21 1.21 1.21 1.21 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.19 1.19 1.19 1.19 1.19 1.19 1.18 1.18 1.18 1.18 1.18
0.82 0.91 2.11 1.11 0.99 0.42 2.56 1.36 1.67 1.07 0.76 0.96 1.44 1.91 2.56 1.25 1.26 1.19 0.78 1.44 0.94 1.45 0.98 1.68 1.19 0.81 5.82 1.01 0.82 1.59 0.86 0.86 1.15 1.42 0.75 0.82 4.68 0.88 1.92 0.77 1.29 1.80 2.21 1.18 0.87 1.44 1.02 1.24 1.59 1.92 0.63 1.73 0.48 1.38 0.77 1.42 0.98 2.15 1.68 1.01 1.25 0.89
ACCEPTED MANUSCRIPT
63.063 72.153 67.1992 48.0084 181.268 75.7476 132.137 90.3187 104.752 151.416 178.252 91.9372 84.1385 146.054 99.9363 120.659 187.296 135.312 78.3857 97.0108 118.959 82.1208 118.512 76.9075 57.7096 103.196 100.067 73.1116 112.627 86.5056 41.0508 28.3232 79.2079 99.7871 83.5767 138.7 50.9348 100.37 86.4502 190.788 64.7205 41.653 44.6177 65.944 98.7759 47.9001 100.699 110.609 119.242 53.2734 77.4297 89.4217 89.7929 126.841 77.7968 50.2356 65.0808 105.775 107.603 168.739 77.0059 79.2379
93.4812 98.7719 93.4915 68.4067 219.443 102.889 151.572 143.867 131.849 196.215 244.4 103.62 114.237 217.272 138.965 165.024 259.01 205.635 151.569 139.4 157.133 106.71 141.101 111.962 84.6038 147.554 147.269 99.8295 139.791 102.802 41.852 40.9937 123.437 162.588 102.138 205.706 65.4481 136.088 125.005 225.939 72.2041 56.4954 64.0657 93.0502 100.308 61.8205 127.239 137.086 169.749 64.8886 107.005 107.352 106.253 144.545 92.8558 48.8532 79.9049 118.947 130.075 177.468 89.7119 98.8834
RI PT
80.7903 76.9452 84.5476 55.6009 178.398 92.9226 80.2394 108.538 106.059 150.557 172.021 92.3141 99.2512 144.834 108.799 130.323 179.188 174.267 121.382 116 121.215 83.3782 160.836 91.7995 74.6996 122.046 136.281 75.5867 118.046 82.9011 38.325 31.3214 101.109 133.66 87.2233 169.967 51.5613 125.836 111.477 182.911 50.816 52.8978 58.3901 70.7834 81.0754 57.0818 107.552 108.089 130.972 54.2751 87.8868 92.3914 79.61 116.655 79.9014 39.2747 67.3915 109.748 128.814 162.287 68.5424 99.0946
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
TE D
Gm15800 Iffo1 Asap2 Smek1 Lancl2 Ube4b Adrbk1 Pde3b Rbm19 Tmem214 Alg1 Sars2 Ifrd1 Arpin Ist1 Bloc1s2 Ngly1 Paxbp1 Aox1 Prdx4 Sidt2 Micu3 Snrpb Arl6 Nmt2 Ptpra Copz1 Yap1 Ppan Adal Letmd1 Hax1 Mroh1 Mogs Rap2c Dnajc21 Kifap3 Stag1 Trabd Slc2a1 Toe1
RT14_MOUSE 28S ribosomal protein S14, mitochondrial RT21_MOUSE 28S ribosomal protein S21, mitochondrial Q6PD28_MOUSE Protein Ppp2r5b ALG11_MOUSE GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase ABH15_MOUSE Abhydrolase domain-containing protein 15 CNNM3_MOUSE Metal transporter CNNM3 PYRD2_MOUSE Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 THNS1_MOUSE Threonine synthase-like 1 AF1L2_MOUSE Actin filament-associated protein 1-like 2 NOL7_MOUSE Nucleolar protein 7 NUCG_MOUSE Endonuclease G, mitochondrial P3H3_MOUSE Prolyl 3-hydroxylase 3 F91A1_MOUSE Protein FAM91A1 TRIO_MOUSE Triple functional domain protein VPS41_MOUSE Vacuolar protein sorting-associated protein 41 homolog DNJC5_MOUSE DnaJ homolog subfamily C member 5 GMPPA_MOUSE Mannose-1-phosphate guanyltransferase alpha FXRD1_MOUSE FAD-dependent oxidoreductase domain-containing protein 1 IF2M_MOUSE Translation initiation factor IF-2, mitochondrial KPRA_MOUSE Phosphoribosyl pyrophosphate synthase-associated protein 1 CD027_MOUSE UPF0609 protein C4orf27 homolog E9PX61_MOUSE Protein Gm15800 IFFO1_MOUSE Intermediate filament family orphan 1 ASAP2_MOUSE Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 P4R3A_MOUSE Serine/threonine-protein phosphatase 4 regulatory subunit 3A LANC2_MOUSE LanC-like protein 2 UBE4B_MOUSE Ubiquitin conjugation factor E4 B ARBK1_MOUSE Beta-adrenergic receptor kinase 1 PDE3B_MOUSE cGMP-inhibited 3',5'-cyclic phosphodiesterase B RBM19_MOUSE Probable RNA-binding protein 19 TM214_MOUSE Transmembrane protein 214 ALG1_MOUSE Chitobiosyldiphosphodolichol beta-mannosyltransferase SYSM_MOUSE Serine--tRNA ligase, mitochondrial IFRD1_MOUSE Interferon-related developmental regulator 1 ARPIN_MOUSE Arpin IST1_MOUSE IST1 homolog BL1S2_MOUSE Biogenesis of lysosome-related organelles complex 1 subunit 2 NGLY1_MOUSE Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase PAXB1_MOUSE PAX3- and PAX7-binding protein 1 AOXA_MOUSE Aldehyde oxidase 1 PRDX4_MOUSE Peroxiredoxin-4 SIDT2_MOUSE SID1 transmembrane family member 2 MICU3_MOUSE Calcium uptake protein 3, mitochondrial RSMB_MOUSE Small nuclear ribonucleoprotein-associated protein B ARL6_MOUSE ADP-ribosylation factor-like protein 6 NMT2_MOUSE Glycylpeptide N-tetradecanoyltransferase 2 PTPRA_MOUSE Receptor-type tyrosine-protein phosphatase alpha COPZ1_MOUSE Coatomer subunit zeta-1 YAP1_MOUSE Yorkie homolog SSF1_MOUSE Suppressor of SWI4 1 homolog ADAL_MOUSE Adenosine deaminase-like protein LTMD1_MOUSE LETM1 domain-containing protein 1 HAX1_MOUSE HCLS1-associated protein X-1 E0CZ22_MOUSE Protein Mroh1 MOGS_MOUSE Mannosyl-oligosaccharide glucosidase RAP2C_MOUSE Ras-related protein Rap-2c E9Q8D0_MOUSE Protein Dnajc21 KIFA3_MOUSE Kinesin-associated protein 3 STAG1_MOUSE Cohesin subunit SA-1 TRABD_MOUSE TraB domain-containing protein GTR1_MOUSE Solute carrier family 2, facilitated glucose transporter member 1 TOE1_MOUSE Target of EGR1 protein 1
EP
Mrps14 Mrps21 Ppp2r5b Alg11 Abhd15 Cnnm3 Pyroxd2 Thnsl1 Afap1l2 Nol7 Endog Leprel2 Fam91a1 Trio Vps41 Dnajc5 Gmppa Foxred1 Mtif2 Prpsap1
AC C
sp|Q9CR88|RT14_MOUSE sp|P58059|RT21_MOUSE tr|Q6PD28|Q6PD28_MOUSE sp|Q3TZM9|ALG11_MOUSE sp|Q5F2F2|ABH15_MOUSE sp|Q32NY4|CNNM3_MOUSE sp|Q3U4I7|PYRD2_MOUSE sp|Q8BH55|THNS1_MOUSE sp|Q5DTU0|AF1L2_MOUSE sp|Q9D7Z3|NOL7_MOUSE sp|O08600|NUCG_MOUSE sp|Q8CG70|P3H3_MOUSE sp|Q3UVG3|F91A1_MOUSE sp|Q0KL02|TRIO_MOUSE sp|Q5KU39|VPS41_MOUSE sp|P60904|DNJC5_MOUSE sp|Q922H4|GMPPA_MOUSE sp|Q3TQB2|FXRD1_MOUSE sp|Q91YJ5|IF2M_MOUSE sp|Q9D0M1|KPRA_MOUSE sp|Q8CFE2|CD027_MOUSE tr|E9PX61|E9PX61_MOUSE sp|Q8BXL9|IFFO1_MOUSE sp|Q7SIG6|ASAP2_MOUSE sp|Q6P2K6|P4R3A_MOUSE sp|Q9JJK2|LANC2_MOUSE sp|Q9ES00|UBE4B_MOUSE sp|Q99MK8|ARBK1_MOUSE sp|Q61409|PDE3B_MOUSE sp|Q8R3C6|RBM19_MOUSE sp|Q8BM55|TM214_MOUSE sp|Q921Q3|ALG1_MOUSE sp|Q9JJL8|SYSM_MOUSE sp|P19182|IFRD1_MOUSE sp|Q9D0A3|ARPIN_MOUSE sp|Q9CX00|IST1_MOUSE sp|Q9CWG9|BL1S2_MOUSE sp|Q9JI78|NGLY1_MOUSE sp|P58501|PAXB1_MOUSE sp|O54754|AOXA_MOUSE sp|O08807|PRDX4_MOUSE sp|Q8CIF6|SIDT2_MOUSE sp|Q9CTY5|MICU3_MOUSE sp|P27048|RSMB_MOUSE sp|O88848|ARL6_MOUSE sp|O70311|NMT2_MOUSE sp|P18052|PTPRA_MOUSE sp|P61924|COPZ1_MOUSE sp|P46938|YAP1_MOUSE sp|Q91YU8|SSF1_MOUSE sp|Q80SY6|ADAL_MOUSE sp|Q924L1|LTMD1_MOUSE sp|O35387|HAX1_MOUSE tr|E0CZ22|E0CZ22_MOUSE sp|Q80UM7|MOGS_MOUSE sp|Q8BU31|RAP2C_MOUSE tr|E9Q8D0|E9Q8D0_MOUSE sp|P70188|KIFA3_MOUSE sp|Q9D3E6|STAG1_MOUSE sp|Q99JY4|TRABD_MOUSE sp|P17809|GTR1_MOUSE sp|Q9D2E2|TOE1_MOUSE
76.0844 76.7652 85.094 53.4835 203.544 95.2192 97.8167 89.6032 115.507 157.852 166.18 112.196 100.492 122.926 105.116 128.168 168.691 155.559 81.5037 109.114 122.983 86.2422 184.434 83.931 69.0306 113.763 126.79 72.4988 127.428 93.2221 49.9891 27.9782 84.2229 106.181 94.3288 148.571 52.0582 122.968 101.44 201.346 59.8316 51.0916 53.0936 61.7606 103.101 56.7895 108.016 109.943 112.309 55.9469 78.7257 96.8424 83.9736 128.78 84.0062 51.2739 68.2066 121.849 133.974 191.697 72.5197 99.8809
56.5918 22.0952 43.3398 57.32 99.753 244.475 73.9618 63.6545 41.4943 97.0479 188.888 48.3325 154.799 190.748 137.133 153.119 215.865 56.4059 72.149 137.692 116.267 121.46 86.39 170.542 54.15 115.565 141.957 79.5384 84.1699 57.8517 52.9939 35.684 77.4415 270.389 66.8715 171.846 38.7548 81.7936 155.48 148.855 140.231 50.0665 60.5815 65.8452 117.189 158.397 109.705 117.041 120.902 280.475 67.7068 54.8172 51.4833 134.129 62.958 55.8592 55.8274 104.424 148.213 293.921 251.855 81.0866
91.6392 70.6424 36.2168 52.8452 128.725 209.191 116.142 101.233 130.876 103.557 262.414 41.8756 107.141 418.838 138.903 103.244 122.939 113.435 104.963 112.662 132.82 139.586 376.6 146.485 69.9463 73.0312 166.992 102.303 110.456 106.355 50.915 67.0432 133.498 88.3328 123.419 172.034 59.3628 122.55 171.158 224.323 154.307 51.3022 52.586 59.9331 112.351 90.3983 68.6355 97.1946 220.305 242.992 88.5248 50.5283 186.767 152.5 53.8521 45.5673 99.2175 85.9749 130.815 220.62 61.6103 61.307
1.18 1.18 1.18 1.18 1.18 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.15 1.15 1.15 1.15 1.15 1.15 1.14 1.14 1.14 1.14 1.14 1.13 1.13 1.13 1.13 1.13 1.13 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.11 1.11
1.03 0.62 0.52 1.06 0.64 2.69 0.90 0.83 0.82 0.66 1.29 0.49 1.43 2.10 1.32 1.02 0.92 0.55 0.89 1.18 1.04 1.58 1.66 1.88 0.94 0.84 1.31 1.22 0.84 0.97 1.31 1.72 1.17 1.54 1.11 1.11 0.96 0.90 1.65 1.00 2.55 1.07 1.10 0.92 1.28 2.37 0.86 0.98 1.36 4.87 0.95 0.58 1.41 1.18 0.74 1.13 1.17 0.88 1.18 1.55 2.15 0.80
ACCEPTED MANUSCRIPT
M AN U
TE D
138.497 45.5682 157.608 72.6146 49.581 182.086 97.2937 117.574 130.636 55.5419 82.7091 36.0743 126.28 80.7849 118.542 132.16 54.4752 87.4987 112.481 116.584 52.6492 66.3229 118.608 68.3183 110.553 57.8821 90.3142 40.7868 87.8215 94.2598 234.502 128.446 68.7387 57.6366 71.4833 108.759 129.543 92.0205 65.2595 125.428 54.8321 43.5723 56.1345 86.4517 67.23 38.0246 78.072 119.32 54.5597 50.8881 53.3526 80.7156 84.4068 63.9854 115.926 125.273 313.489 48.8915 67.8059 144.255 122.041 68.9217
150.236 65.9122 187.217 55.3949 75.4377 159.811 113.78 132.313 157.562 79.0291 97.0006 50.1698 171.417 105.161 129.954 140.613 59.4081 109.995 141.464 133.805 61.7544 81.4726 130.082 93.5471 125.696 76.5103 138.361 56.4605 143.298 110.22 268.029 130.323 77.0031 58.7822 83.6863 108.217 167.294 103.878 80.4743 137.325 59.1142 55.927 67.5363 109.353 83.8502 52.9773 105.599 114.846 54.6879 59.7284 71.1052 109.106 116.808 69.8259 123.338 172.759 334.874 58.0224 62.419 105.534 155.162 91.1598
RI PT
124.217 50.6333 160.26 42.1904 71.6181 113.638 92.9981 104.089 136.694 76.4845 86.7043 40.1862 135.813 97.376 102.214 117.289 59.2555 99.8232 133.293 101.371 55.7474 65.2425 126.459 76.178 102.61 56.5552 119.024 45.0153 129.128 91.8307 209.243 111.707 74.7812 67.1744 79.5603 98.3385 165.504 89.7322 78.4734 105.678 49.7384 44.1488 62.8432 90.3611 67.2083 39.8425 109.275 113.988 57.5975 52.626 58.7188 92.9736 91.8653 72.2858 114.979 138.992 322.682 57.0951 51.7972 132.652 139.316 75.8806
SC
T22D1_MOUSE TSC22 domain family protein 1 2 ASPC1_MOUSE Tether containing UBX domain for GLUT4 2 KPCD_MOUSE Protein kinase C delta type 2 SDF2_MOUSE Stromal cell-derived factor 2 2 Q0VBL3_MOUSE Protein Rbm15 2 MPP10_MOUSE U3 small nucleolar ribonucleoprotein protein MPP10 2 RPE_MOUSE Ribulose-phosphate 3-epimerase 2 ZEB2_MOUSE Zinc finger E-box-binding homeobox 2 2 AP4E1_MOUSE AP-4 complex subunit epsilon-1 2 CRBN_MOUSE Protein cereblon 2 TNR6B_MOUSE Trinucleotide repeat-containing gene 6B protein 2 RPB9_MOUSE DNA-directed RNA polymerase II subunit RPB9 2 LMF1_MOUSE Lipase maturation factor 1 2 F175B_MOUSE BRISC complex subunit Abro1 2 POMP_MOUSE Proteasome maturation protein 2 CIC_MOUSE Protein capicua homolog 2 GCP3_MOUSE Gamma-tubulin complex component 3 2 YIPF4_MOUSE Protein YIPF4 2 D3YYU8_MOUSE Protein Obsl1 2 STAR5_MOUSE StAR-related lipid transfer protein 5 2 TAF10_MOUSE Transcription initiation factor TFIID subunit 10 2 PPIE_MOUSE Peptidyl-prolyl cis-trans isomerase E 2 EMAL4_MOUSE Echinoderm microtubule-associated protein-like 4 2 GDPD1_MOUSE Glycerophosphodiester phosphodiesterase domain-containing protein 1 2 TMA16_MOUSE Translation machinery-associated protein 16 2 BL1S1_MOUSE Biogenesis of lysosome-related organelles complex 1 subunit 1 2 MK03_MOUSE Mitogen-activated protein kinase 3 2 FNBP4_MOUSE Formin-binding protein 4 2 A2AFK4_MOUSE GTP binding protein 5, isoform CRA_a 2 SCMC2_MOUSE Calcium-binding mitochondrial carrier protein SCaMC-2 2 SZRD1_MOUSE SUZ domain-containing protein 1 2 BBX_MOUSE HMG box transcription factor BBX 2 PKHM1_MOUSE Pleckstrin homology domain-containing family M member 1 2 TM230_MOUSE Transmembrane protein 230 2 PLCE_MOUSE 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon 2 IPO4_MOUSE Importin-4 2 RM21_MOUSE 39S ribosomal protein L21, mitochondrial 2 MARK2_MOUSE Serine/threonine-protein kinase MARK2 2 SMRD3_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily 2 D member 3 TDIF2_MOUSE Deoxynucleotidyltransferase terminal-interacting protein 2 2 REPS1_MOUSE RalBP1-associated Eps domain-containing protein 1 2 SMAP2_MOUSE Stromal membrane-associated protein 2 2 CCD94_MOUSE Coiled-coil domain-containing protein 94 2 RM27_MOUSE 39S ribosomal protein L27, mitochondrial 2 HN1L_MOUSE Hematological and neurological expressed 1-like protein 2 MYOV2_MOUSE Myeloma-overexpressed gene 2 protein homolog 2 UXT_MOUSE Protein UXT 2 TF3C4_MOUSE General transcription factor 3C polypeptide 4 2 MCA3_MOUSE Eukaryotic translation elongation factor 1 epsilon-1 2 CCD50_MOUSE Coiled-coil domain-containing protein 50 2 CMC4_MOUSE Cx9C motif-containing protein 4 2 ANO10_MOUSE Anoctamin-10 2 PSMG1_MOUSE Proteasome assembly chaperone 1 2 P66A_MOUSE Transcriptional repressor p66 alpha 2 PDE12_MOUSE 2',5'-phosphodiesterase 12 2 PQBP1_MOUSE Polyglutamine-binding protein 1 2 FBX4_MOUSE F-box only protein 4 2 HDAC2_MOUSE Histone deacetylase 2 2 CDK7_MOUSE Cyclin-dependent kinase 7 2 MOS1_MOUSE Mitochondrial inner membrane organizing system protein 1 2 E9Q3C1_MOUSE Protein C2cd2 2 PIN4_MOUSE Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 2
EP
Tsc22d1 Aspscr1 Prkcd Sdf2 Rbm15 Mphosph10 Rpe Zeb2 Ap4e1 Crbn Tnrc6b Polr2i Lmf1 Fam175b Pomp Cic Tubgcp3 Yipf4 Obsl1 Stard5 Taf10 Ppie Eml4 Gdpd1 Tma16 Bloc1s1 Mapk3 Fnbp4 Mtg2 Slc25a25 Szrd1 Bbx Plekhm1 Tmem230 Agpat5 Ipo4 Mrpl21 Mark2 Smarcd3 Dnttip2 Reps1 Smap2 Ccdc94 Mrpl27 Hn1l Myeov2 Uxt Gtf3c4 Eef1e1 Ccdc50 Cmc4 Ano10 Psmg1 Gatad2a Pde12 Pqbp1 Fbxo4 Hdac2 Cdk7 Minos1 C2cd2 Pin4
AC C
sp|P62500|T22D1_MOUSE sp|Q8VBT9|ASPC1_MOUSE sp|P28867|KPCD_MOUSE sp|Q9DCT5|SDF2_MOUSE tr|Q0VBL3|Q0VBL3_MOUSE sp|Q810V0|MPP10_MOUSE sp|Q8VEE0|RPE_MOUSE sp|Q9R0G7|ZEB2_MOUSE sp|Q80V94|AP4E1_MOUSE sp|Q8C7D2|CRBN_MOUSE sp|Q8BKI2|TNR6B_MOUSE sp|P60898|RPB9_MOUSE sp|Q3U3R4|LMF1_MOUSE sp|Q3TCJ1|F175B_MOUSE sp|Q9CQT5|POMP_MOUSE sp|Q924A2|CIC_MOUSE sp|P58854|GCP3_MOUSE sp|Q8C407|YIPF4_MOUSE tr|D3YYU8|D3YYU8_MOUSE sp|Q9EPQ7|STAR5_MOUSE sp|Q8K0H5|TAF10_MOUSE sp|Q9QZH3|PPIE_MOUSE sp|Q3UMY5|EMAL4_MOUSE sp|Q9CRY7|GDPD1_MOUSE sp|Q9CR02|TMA16_MOUSE sp|O55102|BL1S1_MOUSE sp|Q63844|MK03_MOUSE sp|Q6ZQ03|FNBP4_MOUSE tr|A2AFK4|A2AFK4_MOUSE sp|A2ASZ8|SCMC2_MOUSE sp|Q6NXN1|SZRD1_MOUSE sp|Q8VBW5|BBX_MOUSE sp|Q7TSI1|PKHM1_MOUSE sp|Q8CIB6|TM230_MOUSE sp|Q9D1E8|PLCE_MOUSE sp|Q8VI75|IPO4_MOUSE sp|Q9D1N9|RM21_MOUSE sp|Q05512|MARK2_MOUSE sp|Q6P9Z1|SMRD3_MOUSE sp|Q8R2M2|TDIF2_MOUSE sp|O54916|REPS1_MOUSE sp|Q7TN29|SMAP2_MOUSE sp|Q9D6J3|CCD94_MOUSE sp|Q99N92|RM27_MOUSE sp|Q6PGH2|HN1L_MOUSE sp|Q3U898|MYOV2_MOUSE sp|Q9WTZ0|UXT_MOUSE sp|Q8BMQ2|TF3C4_MOUSE sp|Q9D1M4|MCA3_MOUSE sp|Q810U5|CCD50_MOUSE sp|Q61908|CMC4_MOUSE sp|Q8BH79|ANO10_MOUSE sp|Q9JK23|PSMG1_MOUSE sp|Q8CHY6|P66A_MOUSE sp|Q3TIU4|PDE12_MOUSE sp|Q91VJ5|PQBP1_MOUSE sp|Q8CHQ0|FBX4_MOUSE sp|P70288|HDAC2_MOUSE sp|Q03147|CDK7_MOUSE sp|Q7TNS2|MOS1_MOUSE tr|E9Q3C1|E9Q3C1_MOUSE sp|Q9CWW6|PIN4_MOUSE
142.573 41.2882 166.638 72.3593 59.2974 168.727 97.2829 113.478 138.752 66.7842 90.1018 33.9756 117.767 91.3888 113.53 134.508 65.7961 96.1851 128.951 105.823 57.3421 62.8295 138.501 64.58 107.465 48.6596 90.3667 37.2401 93.4488 92.6447 215.485 130.644 78.8706 76.721 80.0947 116.301 152.338 92.8471 74.72 112.209 53.7206 38.5177 60.3765 80.6989 60.3753 30.4533 94.9529 134.883 65.3321 50.9417 48.6135 76.4052 71.4433 75.4029 121.921 107.897 340.348 54.4629 64.4318 188.061 121.835 62.168
134.628 126.924 330.312 52.2267 73.906 156.709 55.2146 99.4748 138.533 71.1858 48.0304 178.14 116.761 71.3339 55.5816 85.2299 69.1678 186.966 70.9758 224.831 43.7119 53.3301 163.746 85.0944 94.4598 45.3592 109.202 100.537 33.479 109.886 146.232 212.254 61.7752 62.9339 114.893 150.114 92.6815 90.2347 44.1557 242.305 62.8724 29.0763 42.3988 95.3128 37.1846 41.4875 128.817 121.393 112.847 33.151 63.035 143.8 277.214 93.6193 128.731 76.5962 200.014 75.4235 55.9387 170.544 114.643 58.6956
177.944 215.043 224.391 80.11 119.848 169.021 169.469 243.667 135.568 56.6888 86.8235 521.247 192.823 54.4915 137.3 189.365 48.326 299.803 81.7178 354.021 82.8066 111.634 137.105 90.5148 157.075 76.8098 70.4251 128.21 120.312 89.0259 395.111 263.726 71.5794 51.5697 58.8114 66.9039 116.608 178.746 48.1266 523.932 94.6395 62.7451 55.1487 228.828 75.9826 85.7036 104.83 136.198 105.859 99.6097 129.77 162.198 191.631 208.649 122.627 131.439 675.542 43.0109 65.9633 202.077 163.144 139.273
1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06
1.19 3.55 1.75 1.15 1.60 1.10 1.18 1.55 1.03 0.97 0.80 9.17 1.18 0.71 0.87 1.10 1.03 2.60 0.62 2.66 1.17 1.25 1.23 1.22 1.18 1.07 0.86 2.67 0.71 1.07 1.22 1.98 0.93 0.92 1.15 1.05 0.71 1.48 0.64 3.32 1.51 1.05 0.82 1.83 0.84 1.63 1.25 1.10 1.95 1.28 1.72 1.76 2.66 2.22 1.09 0.79 1.38 1.12 1.02 1.35 1.06 1.37
ACCEPTED MANUSCRIPT
TE D
86.0644 98.336 60.6945 177.337 54.3246 177.082 84.0415 122.52 112.3 87.5244 182.991 120.181 124.044 83.3957 158.706 110.041 62.0516 102.734 76.7829 41.4591 111.277 140.235 83.7824 151.958 29.8587 85.5899 107.101 298.678 43.9697 110.233 77.5663 87.8929 115.758 182.112 119.917 161.356 85.2015 124.835 122.618 44.0809 175.247 123.668 124.791 50.518 174.664 32.4632 38.345 93.6935 201.258 132.023 119.686 126.803 89.1872 59.348 59.2852 76.3357 112.949 150.313 97.9967 59.267 128.587 91.2776
107.368 142.407 63.6341 216.831 47.7481 191.013 127.062 136.285 150.656 109.343 164.732 151.527 145.508 99.7603 193.114 129.005 66.5377 125.426 91.9939 49.4364 144.427 132.855 102.612 205.368 28.6639 91.5261 112.97 338.232 45.7208 131.327 81.7856 96.1705 148.544 205.627 153.806 217.952 107.617 168.931 162.052 54.7838 207.523 136.694 151.711 55.6059 176.164 46.9115 55.9436 114.721 194.131 126.538 146.655 136.193 97.4114 76.9481 65.7297 75.8928 89.8546 100.327 117.254 69.0169 142.196 94.2812
RI PT
97.6084 128.187 50.885 182.723 55.8444 169.225 124.284 166.788 126.463 106.245 152.847 143.223 126.665 88.6217 215.489 105.215 50.9209 117.341 79.0958 48.9982 129.249 112.94 76.3152 195.883 23.0424 77.7428 96.486 281.163 40.4135 136.563 69.1221 91.9755 143.099 213.782 138.309 197.092 98.112 171.08 150.879 49.1754 180.918 124.351 138.818 50.9486 150.479 49.9558 46.8867 109.042 203.326 128.305 131.396 118.206 79.3222 71.2471 54.7496 66.2762 84.3906 88.532 118.498 71.9029 133.943 79.1111
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
GMPPB_MOUSE Mannose-1-phosphate guanyltransferase beta STA5B_MOUSE Signal transducer and activator of transcription 5B MIPEP_MOUSE Mitochondrial intermediate peptidase SBNO1_MOUSE Protein strawberry notch homolog 1 UBP46_MOUSE Ubiquitin carboxyl-terminal hydrolase 46 THOC1_MOUSE THO complex subunit 1 DPP8_MOUSE Dipeptidyl peptidase 8 O88325_MOUSE Alpha-N-acetylglucosaminidase IMP2L_MOUSE Mitochondrial inner membrane protease subunit 2 IRS2_MOUSE Insulin receptor substrate 2 ARI1A_MOUSE AT-rich interactive domain-containing protein 1A DTD2_MOUSE Probable D-tyrosyl-tRNA(Tyr) deacylase 2 MRT4_MOUSE mRNA turnover protein 4 homolog MET17_MOUSE Methyltransferase-like protein 17, mitochondrial GALT2_MOUSE Polypeptide N-acetylgalactosaminyltransferase 2 ATP5S_MOUSE ATP synthase subunit s, mitochondrial E9Q394_MOUSE Protein Akap13 PECR_MOUSE Peroxisomal trans-2-enoyl-CoA reductase HNRH1_MOUSE Heterogeneous nuclear ribonucleoprotein H MINP1_MOUSE Multiple inositol polyphosphate phosphatase 1 ZN346_MOUSE Zinc finger protein 346 GNPTG_MOUSE N-acetylglucosamine-1-phosphotransferase subunit gamma SYWM_MOUSE Tryptophan--tRNA ligase, mitochondrial NEMF_MOUSE Nuclear export mediator factor Nemf TBA3_MOUSE Tubulin alpha-3 chain IKBA_MOUSE NF-kappa-B inhibitor alpha TRIA1_MOUSE TP53-regulated inhibitor of apoptosis 1 TITIN_MOUSE Titin M3K7_MOUSE Mitogen-activated protein kinase kinase kinase 7 MGAT2_MOUSE Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase WASH1_MOUSE WAS protein family homolog 1 UBP10_MOUSE Ubiquitin carboxyl-terminal hydrolase 10 TDRKH_MOUSE Tudor and KH domain-containing protein TYW1_MOUSE S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase ERCC2_MOUSE TFIIH basal transcription factor complex helicase XPD subunit ADIP_MOUSE Afadin- and alpha-actinin-binding protein NUD13_MOUSE Nucleoside diphosphate-linked moiety X motif 13 TPC_MOUSE Mitochondrial thiamine pyrophosphate carrier SRR_MOUSE Serine racemase 2ABD_MOUSE Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform SC5A3_MOUSE Sodium/myo-inositol cotransporter STK16_MOUSE Serine/threonine-protein kinase 16 RM53_MOUSE 39S ribosomal protein L53, mitochondrial GLRX2_MOUSE Glutaredoxin-2, mitochondrial UB2FA_MOUSE NEDD8-conjugating enzyme UBE2F PIGN_MOUSE GPI ethanolamine phosphate transferase 1 STBD1_MOUSE Starch-binding domain-containing protein 1 MARH5_MOUSE E3 ubiquitin-protein ligase MARCH5 GCC1_MOUSE GRIP and coiled-coil domain-containing protein 1 SCRB1_MOUSE Scavenger receptor class B member 1 P4K2A_MOUSE Phosphatidylinositol 4-kinase type 2-alpha CARF_MOUSE CDKN2A-interacting protein RM42_MOUSE 39S ribosomal protein L42, mitochondrial E9Q3R9_MOUSE Protein Zbtb21 FGOP2_MOUSE FGFR1 oncogene partner 2 homolog BRK1_MOUSE Protein BRICK1 AP4A_MOUSE Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] LAR4B_MOUSE La-related protein 4B UBP1_MOUSE Ubiquitin carboxyl-terminal hydrolase 1 GPAT4_MOUSE Glycerol-3-phosphate acyltransferase 4 VWA9_MOUSE von Willebrand factor A domain-containing protein 9 NDUS8_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
EP
Gmppb Stat5b Mipep Sbno1 Usp46 Thoc1 Dpp8 Naglu Immp2l Irs2 Arid1a Dtd2 Mrto4 Mettl17 Galnt2 Atp5s Akap13 Pecr Hnrnph1 Minpp1 Znf346 Gnptg Wars2 Nemf Tuba3a Nfkbia Triap1 Ttn Map3k7 Mgat2 Wash1 Usp10 Tdrkh Tyw1 Ercc2 Ssx2ip Nudt13 Slc25a19 Srr Ppp2r2d Slc5a3 Stk16 Mrpl53 Glrx2 Ube2f Pign Stbd1 05-Mar Gcc1 Scarb1 Pi4k2a Cdkn2aip Mrpl42 Zbtb21 Fgfr1op2 Brk1 Nudt2 Larp4b Usp1 Agpat6 Vwa9 Ndufs8
AC C
sp|Q8BTZ7|GMPPB_MOUSE sp|P42232|STA5B_MOUSE sp|A6H611|MIPEP_MOUSE sp|Q689Z5|SBNO1_MOUSE sp|P62069|UBP46_MOUSE sp|Q8R3N6|THOC1_MOUSE sp|Q80YA7|DPP8_MOUSE tr|O88325|O88325_MOUSE sp|Q8BPT6|IMP2L_MOUSE sp|P81122|IRS2_MOUSE sp|A2BH40|ARI1A_MOUSE sp|Q8BHA3|DTD2_MOUSE sp|Q9D0I8|MRT4_MOUSE sp|Q3U2U7|MET17_MOUSE sp|Q6PB93|GALT2_MOUSE sp|Q9CRA7|ATP5S_MOUSE tr|E9Q394|E9Q394_MOUSE sp|Q99MZ7|PECR_MOUSE sp|O35737|HNRH1_MOUSE sp|Q9Z2L6|MINP1_MOUSE sp|Q9R0B7|ZN346_MOUSE sp|Q6S5C2|GNPTG_MOUSE sp|Q9CYK1|SYWM_MOUSE sp|Q8CCP0|NEMF_MOUSE sp|P05214|TBA3_MOUSE sp|Q9Z1E3|IKBA_MOUSE sp|Q9D8Z2|TRIA1_MOUSE sp|A2ASS6|TITIN_MOUSE sp|Q62073|M3K7_MOUSE sp|Q921V5|MGAT2_MOUSE sp|Q8VDD8|WASH1_MOUSE sp|P52479|UBP10_MOUSE sp|Q80VL1|TDRKH_MOUSE sp|Q8BJM7|TYW1_MOUSE sp|O08811|ERCC2_MOUSE sp|Q8VC66|ADIP_MOUSE sp|Q8JZU0|NUD13_MOUSE sp|Q9DAM5|TPC_MOUSE sp|Q9QZX7|SRR_MOUSE sp|Q925E7|2ABD_MOUSE sp|Q9JKZ2|SC5A3_MOUSE sp|O88697|STK16_MOUSE sp|Q9D1H8|RM53_MOUSE sp|Q923X4|GLRX2_MOUSE sp|Q9CY34|UB2FA_MOUSE sp|Q9R1S3|PIGN_MOUSE sp|Q8C7E7|STBD1_MOUSE sp|Q3KNM2|MARH5_MOUSE sp|Q9D4H2|GCC1_MOUSE sp|Q61009|SCRB1_MOUSE sp|Q2TBE6|P4K2A_MOUSE sp|Q8BI72|CARF_MOUSE sp|Q9CPV3|RM42_MOUSE tr|E9Q3R9|E9Q3R9_MOUSE sp|Q9CRA9|FGOP2_MOUSE sp|Q91VR8|BRK1_MOUSE sp|P56380|AP4A_MOUSE sp|Q6A0A2|LAR4B_MOUSE sp|Q8BJQ2|UBP1_MOUSE sp|Q8K2C8|GPAT4_MOUSE sp|Q8R3P6|VWA9_MOUSE sp|Q8K3J1|NDUS8_MOUSE
87.0296 97.3223 54.4318 164.121 68.7454 174.853 92.5042 168.593 100.912 94.5441 188.634 125.616 118.276 81.0625 200.076 97.1736 52.123 105.691 71.3399 45.1921 106.577 130.999 64.1045 156.69 26.3728 78.3474 98.5839 263.728 41.8801 124.832 70.4675 90.4651 120.023 204.192 113.36 152.865 81.8603 136.806 120.23 41.414 159.815 118.645 119.654 48.8373 158.482 37.8375 31.6497 93.6311 221.35 140.746 111.082 115.306 75.434 56.9218 51.1369 70.1749 112.156 143.972 104.161 65.1057 125.41 79.3772
106.23 97.7986 49.3729 232.914 45.5965 200.195 62.7272 102.712 98.4985 96.2503 180.187 86.634 121.521 73.549 172.718 151.398 65.4917 121.617 80.8225 28.2243 72.4417 55.2241 45.0909 302.042 717.452 54.9043 40.2498 266.033 52.4841 169.851 57.4042 67.3327 64.7031 141.973 141.623 104.989 73.8539 147.482 166.158 30.9514 251.167 119.868 71.0565 28.614 117.128 43.9568 106.441 267.789 162.059 98.1365 145.683 100.527 45.3976 43.2698 42.4878 148.133 58.1849 62.2602 97.7218 99.3723 131.409 61.4428
70.3344 64.2872 66.0377 278.615 39.6464 175.38 71.4472 41.9092 179.559 142.99 223.716 89.4942 154.309 77.3051 161.872 232.307 100.856 92.7819 147.263 13.869 125.835 142.311 50.3999 482.997 678.656 132.439 157.749 350.154 110.208 265.426 123.069 75.7953 159.473 163.663 143.227 232.972 101.666 93.3111 193.611 56.064 230.309 134.503 207.93 87.569 319.499 35.379 2.8527 248.563 284.656 99.9633 75.708 150.254 142.262 81.6265 131.708 293.94 90.8775 101.348 90.9525 127.348 95.0168 51.4286
1.06 1.06 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02
0.96 0.72 1.03 1.42 0.77 1.08 0.64 0.50 1.16 1.23 1.20 0.67 1.10 0.88 0.89 1.78 1.47 0.97 1.46 0.47 0.82 0.78 0.60 2.26 26.39 1.15 0.97 1.06 1.93 1.76 1.23 0.80 0.87 0.77 1.10 0.94 0.96 0.81 1.32 0.93 1.35 1.03 1.06 1.15 1.34 0.96 1.28 2.55 1.10 0.76 0.88 1.02 1.11 0.96 1.53 3.10 0.76 0.68 0.87 1.73 0.86 0.66
ACCEPTED MANUSCRIPT
81.3548 61.6227 89.3863 110.593 86.7299 86.223 146.422 117.275 45.2917 134.344 160.853 125.597 181.148 65.871 51.1078 162.922 169.182 45.5882 133.401 164.534 59.9763 100.524 114.097 91.139 46.3237 125.882 144.126 129.855 64.9918 40.2452 195.908 159.145 94.0227 136.755 31.2726 72.4038 80.5606 70.8971 112.975 106.473 125.798 59.5174 59.2037 147.283 55.6892 99.4282 52.5706 88.0195 92.9744 207.326 77.7164 70.4511 89.1036 92.6199 92.9428 107.83 147.057 145.316 36.6018 89.4878 50.9453 192.934
92.7423 64.5333 110.931 128.549 79.88 80.8919 165.825 159.592 42.695 152.996 186.602 146.114 212.585 61.7243 47.985 142.089 145.691 53.7801 150.038 214.895 64.3517 90.6108 110.704 111.096 62.2835 154.194 148.111 136.012 94.1505 62.8958 210.222 157.248 103.733 164.269 43.418 76.8597 93.1849 85.5627 132.395 113.278 143.506 51.4671 65.1859 153.75 53.9165 120.536 54.6079 90.9831 72.745 222.254 84.9814 85.6282 85.4644 100.821 122.264 122.308 80.4742 180.407 43.5119 120.199 60.9927 194.545
SC
RI PT
85.4018 52.0498 115.156 104.754 75.2872 68.4648 165.039 149.381 39.7994 148.376 162.463 161.622 202.22 57.1174 55.4037 149.557 119.366 47.5298 133.053 204.953 54.2738 84.2893 98.3697 109.209 58.5262 153.129 163.785 110.013 98.6002 59.8833 188.783 122.738 91.3487 156.642 42.6215 73.5941 81.8597 80.942 114.968 117.952 150.163 42.025 55.1379 142.327 52.1499 112.54 58.6604 82.1242 97.1184 212.325 79.3062 77.3822 107.174 88.4157 116.248 117.008 126.139 166.725 40.6997 96.7884 49.8079 175.56
M AN U
TE D
Diaph1 Ints12 Pik3r1 Lsm14b Ppp1cc Reep3 Ccdc9 Armc1 Chkb Slu7 Sugp1 Tacc1 Cmtr1 Pdpk1 Wnk4 Lsm3 Ccdc51 Nudt8 Slc25a42 Vps36 Hmgn1 Irf2 Phf6 Rnf114 Sirt4 Anapc1 Srp14 Agpat4 Dctn6 Lsm1 Exosc9 Pqlc3 Sap30bp Trim33 Ado Xpo4 Nudt12 R3hcc1 Rps29 Prkra Cwc15
KPCE_MOUSE Protein kinase C epsilon type 2 DLGP4_MOUSE Disks large-associated protein 4 2 GGCT_MOUSE Gamma-glutamylcyclotransferase 2 TUSC5_MOUSE Tumor suppressor candidate 5 homolog 2 VPS18_MOUSE Vacuolar protein sorting-associated protein 18 homolog 2 BCL7C_MOUSE B-cell CLL/lymphoma 7 protein family member C 2 HSDL1_MOUSE Inactive hydroxysteroid dehydrogenase-like protein 1 2 PHF8_MOUSE Histone lysine demethylase PHF8 2 DPOLB_MOUSE DNA polymerase beta 2 NUP53_MOUSE Nucleoporin NUP53 2 PPDPF_MOUSE Pancreatic progenitor cell differentiation and proliferation factor 2 AGO4_MOUSE Protein argonaute-4 2 TIAR_MOUSE Nucleolysin TIAR 2 TAP26_MOUSE Thyroid transcription factor 1-associated protein 26 2 BID_MOUSE BH3-interacting domain death agonist 2 KISHB_MOUSE Protein kish-B 2 BIN3_MOUSE Bridging integrator 3 2 NSRP1_MOUSE Nuclear speckle splicing regulatory protein 1 2 CYTSA_MOUSE Cytospin-A 2 TRI36_MOUSE E3 ubiquitin-protein ligase Trim36 2 CJ032_MOUSE UPF0693 protein C10orf32 homolog 2 DIAP1_MOUSE Protein diaphanous homolog 1 2 INT12_MOUSE Integrator complex subunit 12 2 P85A_MOUSE Phosphatidylinositol 3-kinase regulatory subunit alpha 2 LS14B_MOUSE Protein LSM14 homolog B 2 PP1G_MOUSE Isoform Gamma-2 of Serine/threonine-protein phosphatase PP1-gamma catalytic subunit 2 REEP3_MOUSE Receptor expression-enhancing protein 3 2 CCDC9_MOUSE Coiled-coil domain-containing protein 9 2 ARMC1_MOUSE Armadillo repeat-containing protein 1 2 CHKB_MOUSE Choline/ethanolamine kinase 2 SLU7_MOUSE Pre-mRNA-splicing factor SLU7 2 SUGP1_MOUSE SURP and G-patch domain-containing protein 1 2 TACC1_MOUSE Transforming acidic coiled-coil-containing protein 1 2 CMTR1_MOUSE Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 2 PDPK1_MOUSE 3-phosphoinositide-dependent protein kinase 1 2 WNK4_MOUSE Serine/threonine-protein kinase WNK4 2 LSM3_MOUSE U6 snRNA-associated Sm-like protein LSm3 2 CCD51_MOUSE Coiled-coil domain-containing protein 51 2 NUDT8_MOUSE Nucleoside diphosphate-linked moiety X motif 8, mitochondrial 2 S2542_MOUSE Mitochondrial coenzyme A transporter SLC25A42 2 VPS36_MOUSE Vacuolar protein-sorting-associated protein 36 2 HMGN1_MOUSE Non-histone chromosomal protein HMG-14 2 IRF2_MOUSE Interferon regulatory factor 2 2 PHF6_MOUSE PHD finger protein 6 2 RN114_MOUSE E3 ubiquitin-protein ligase RNF114 2 SIR4_MOUSE NAD-dependent protein deacetylase sirtuin-4 2 APC1_MOUSE Anaphase-promoting complex subunit 1 2 SRP14_MOUSE Signal recognition particle 14 kDa protein 2 PLCD_MOUSE 1-acyl-sn-glycerol-3-phosphate acyltransferase delta 2 DCTN6_MOUSE Dynactin subunit 6 2 LSM1_MOUSE U6 snRNA-associated Sm-like protein LSm1 2 EXOS9_MOUSE Exosome complex component RRP45 2 PQLC3_MOUSE PQ-loop repeat-containing protein 3 2 S30BP_MOUSE SAP30-binding protein 2 TRI33_MOUSE E3 ubiquitin-protein ligase TRIM33 2 AEDO_MOUSE 2-aminoethanethiol dioxygenase 2 XPO4_MOUSE Exportin-4 2 NUD12_MOUSE Peroxisomal NADH pyrophosphatase NUDT12 2 R3HC1_MOUSE R3H and coiled-coil domain-containing protein 1 2 RS29_MOUSE 40S ribosomal protein S29 2 PRKRA_MOUSE Interferon-inducible double-stranded RNA-dependent protein kinase activator A 2 CWC15_MOUSE Spliceosome-associated protein CWC15 homolog 2
EP
Prkce Dlgap4 Ggct Tusc5 Vps18 Bcl7c Hsdl1 Phf8 Polb Nup35 Ppdpf Ago4 Tial1 Ccdc59 Bid Tmem167b Bin3 Nsrp1 Specc1l Trim36
AC C
sp|P16054|KPCE_MOUSE sp|B1AZP2|DLGP4_MOUSE sp|Q9D7X8|GGCT_MOUSE sp|Q8C838|TUSC5_MOUSE sp|Q8R307|VPS18_MOUSE sp|O08664|BCL7C_MOUSE sp|Q8BTX9|HSDL1_MOUSE sp|Q80TJ7|PHF8_MOUSE sp|Q8K409|DPOLB_MOUSE sp|Q8R4R6|NUP53_MOUSE sp|Q9CR37|PPDPF_MOUSE sp|Q8CJF8|AGO4_MOUSE sp|P70318|TIAR_MOUSE sp|Q8R2N0|TAP26_MOUSE sp|P70444|BID_MOUSE sp|Q80X45|KISHB_MOUSE sp|Q9JI08|BIN3_MOUSE sp|Q5NCR9|NSRP1_MOUSE sp|Q2KN98|CYTSA_MOUSE sp|Q80WG7|TRI36_MOUSE sp|Q9CRC6|CJ032_MOUSE sp|O08808|DIAP1_MOUSE sp|Q9D168|INT12_MOUSE sp|P26450|P85A_MOUSE sp|Q8CGC4|LS14B_MOUSE sp|P63087-2|PP1G_MOUSE sp|Q99KK1|REEP3_MOUSE sp|Q8VC31|CCDC9_MOUSE sp|Q9D7A8|ARMC1_MOUSE sp|O55229|CHKB_MOUSE sp|Q8BHJ9|SLU7_MOUSE sp|Q8CH02|SUGP1_MOUSE sp|Q6Y685|TACC1_MOUSE sp|Q9DBC3|CMTR1_MOUSE sp|Q9Z2A0|PDPK1_MOUSE sp|Q80UE6|WNK4_MOUSE sp|P62311|LSM3_MOUSE sp|Q3URS9|CCD51_MOUSE sp|Q9CR24|NUDT8_MOUSE sp|Q8R0Y8|S2542_MOUSE sp|Q91XD6|VPS36_MOUSE sp|P18608|HMGN1_MOUSE sp|P23906|IRF2_MOUSE sp|Q9D4J7|PHF6_MOUSE sp|Q9ET26|RN114_MOUSE sp|Q8R216|SIR4_MOUSE sp|P53995|APC1_MOUSE sp|P16254|SRP14_MOUSE sp|Q8K4X7|PLCD_MOUSE sp|Q9WUB4|DCTN6_MOUSE sp|Q8VC85|LSM1_MOUSE sp|Q9JHI7|EXOS9_MOUSE sp|Q8C6U2|PQLC3_MOUSE sp|Q02614|S30BP_MOUSE sp|Q99PP7|TRI33_MOUSE sp|Q6PDY2|AEDO_MOUSE sp|Q9ESJ0|XPO4_MOUSE sp|Q9DCN1|NUD12_MOUSE sp|Q8BSI6|R3HC1_MOUSE sp|P62274|RS29_MOUSE sp|Q9WTX2|PRKRA_MOUSE sp|Q9JHS9|CWC15_MOUSE
77.0071 51.1133 97.0576 90.2844 84.6567 76.1323 150.166 110.912 43.6227 133.712 141.147 145.033 175.974 62.4843 59.5804 173.246 145.223 40.058 118.305 157.078 50.6318 95.3731 103.004 90.2761 42.9603 125.641 160.706 104.479 69.8522 37.4649 175.004 125.016 81.7517 128.955 30.2836 68.6216 68.2977 65.3017 93.8821 109.461 130.299 49.2746 48.2415 133.273 52.8541 89.1319 55.3779 77.2203 114.85 191.632 69.772 59.9711 107.782 77.2791 83.1453 98.4602 186.955 124.74 32.08 61.7793 37.3319 164.92
98.3303 40.079 91.7493 69.5796 87.9683 73.6101 167.465 101.613 35.8024 144.673 63.0893 99.6263 236.461 44.6891 62.5457 200.087 68.4708 45.4416 37.4071 94.2228 33.6408 90.4621 69.0595 69.634 35.5393 140.296 125.466 34.833 76.4494 35.1213 117.869 141.574 41.41 66.9464 46.5842 71.7497 63.1677 85.382 144.719 98.4296 160.566 56.2896 39.9202 149.405 162.862 68.6441 47.4343 69.5144 142.802 186.29 52.1521 84.5896 194.166 50.9467 150.477 72.3407 198.593 209.284 29.4466 149.54 136.73 114.92
124.497 72.8293 137.005 38.0411 75.4315 151.684 147.926 130.775 54.1466 171.937 234.713 82.569 417.925 74.3133 96.1584 261.934 190.327 79.0239 133.32 120.098 66.0911 136.616 190.523 120.346 66.3479 107.29 127.202 28.7784 117.169 24.6234 218.192 216.241 111.185 49.1594 49.3315 166.428 133.066 74.8862 270.928 123.106 168.894 84.1981 35.8175 218.222 294.177 104.427 80.0536 106.499 136.287 404.542 96.6366 57.5477 165.353 140.505 79.1952 119.301 168.26 235.274 49.5475 281.236 213.621 206.566
1.02 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98
1.34 0.99 1.12 0.50 1.01 1.46 1.01 0.87 1.06 1.12 0.92 0.63 1.71 0.97 1.49 1.48 0.90 1.34 0.64 0.58 0.87 1.23 1.22 0.95 0.97 0.89 0.82 0.27 1.18 0.60 0.87 1.27 0.82 0.40 1.30 1.63 1.21 1.06 1.82 0.99 1.19 1.38 0.66 1.27 4.24 0.82 1.15 1.03 1.47 1.41 0.95 0.96 1.83 1.06 1.10 0.85 1.34 1.42 1.02 2.31 3.48 0.87
ACCEPTED MANUSCRIPT
121.356 92.4878 115.235 99.6987 88.4859 134.033 127.574 63.7101 153.447 127.656 112.469 61.6945 49.352 117.907 68.7144 62.1459 103.616 105.318 113.406 123.819 53.3609 72.9646 95.1306 189.926 180.863 71.7828 121.216 136.443 173.988 215.101 72.166 71.2026 106.677 63.5997 78.627 187.401 151.887 208.295 166.335 94.5281 55.5779 108.528 55.9248 103.338 134.981 117.544 99.8074 68.2032 86.6338 91.3658 137.201 39.9702 89.4279 121.593 59.1926 124.167 82.2376 82.0744 54.2563 273.982 150.58 99.8265
157.355 80.002 123.373 119.962 84.5525 104.199 85.3963 67.9958 136.648 137.202 119.46 62.5563 56.9654 113.47 70.6296 61.467 124.716 111.825 130.097 146.768 56.283 83.0596 88.4655 179.366 200.86 64.6922 123.818 157.817 210.075 203.458 66.4849 70.7109 123.536 68.3163 63.4897 172.924 134.643 232.482 151.999 82.3396 58.5172 95.2788 60.5831 114.009 115.66 103.503 84.2963 70.7908 99.2802 68.765 131.565 52.0296 119.521 138.184 66.8429 80.7016 81.5324 78.3151 46.8057 313.883 132.474 111.458
RI PT
144.348 76.6056 96.0541 112.897 90.7222 139.094 87.2812 63.7767 128.898 178.569 113.865 57.8844 56.9109 107.05 67.0361 51.5933 126.63 107.595 131.818 147.366 62.4394 77.673 95.6039 160.365 192.685 66.331 127.222 156.963 231.319 198.683 71.1275 64.1272 123.468 62.0891 94.382 164.145 129.634 223.788 164.594 89.0341 64.2806 94.47 65.3946 108.127 169.125 85.3804 94.6517 78.0304 88.4981 100.228 116.397 54.6848 104.3 137.739 67.2542 67.9865 95.3093 71.2516 39.4406 329.787 134.079 94.1463
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
TE D
Armc6 Fam107b Tmem87b Cdkn2aipnl Ehmt1 Commd10 Cpsf7 Grb2 Rab11fip5 Cmas Rnf20 Fip1l1 Vkorc1l1 Homer1 Med10 Rfk Pum1 Sec23b Gpcpd1 Tbl1x Gsta3 Ccm2 Tmed3 Ncs1 Mrpl35 Tgs1 Stambp Dock9 Gpatch11 Mtpap Mmaa Habp4 Setd1a Srxn1 Stk38l R3hdm1 Snx16 Bap18 Champ1 Wbp4
NPC1_MOUSE Niemann-Pick C1 protein RBM7_MOUSE RNA-binding protein 7 FKBPL_MOUSE FK506-binding protein-like CNOT3_MOUSE CCR4-NOT transcription complex subunit 3 DNJC9_MOUSE DnaJ homolog subfamily C member 9 STT3B_MOUSE Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B MKLN1_MOUSE Muskelin PHF5A_MOUSE PHD finger-like domain-containing protein 5A CSTFT_MOUSE Cleavage stimulation factor subunit 2 tau variant XPO7_MOUSE Exportin-7 SFSWA_MOUSE Splicing factor, suppressor of white-apricot homolog RBM4_MOUSE RNA-binding protein 4 QPCTL_MOUSE Glutaminyl-peptide cyclotransferase-like protein RMD3_MOUSE Regulator of microtubule dynamics protein 3 ZFY19_MOUSE Zinc finger FYVE domain-containing protein 19 CC104_MOUSE Coiled-coil domain-containing protein 104 HP1B3_MOUSE Isoform 2 of Heterochromatin protein 1-binding protein 3 NT5D3_MOUSE 5'-nucleotidase domain-containing protein 3 IFI5A_MOUSE Interferon-activable protein 205-A NAA40_MOUSE N-alpha-acetyltransferase 40 WDR4_MOUSE tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 CQ089_MOUSE Uncharacterized protein C17orf89 homolog ARMC6_MOUSE Armadillo repeat-containing protein 6 F107B_MOUSE Protein FAM107B TM87B_MOUSE Transmembrane protein 87B C2AIL_MOUSE CDKN2AIP N-terminal-like protein EHMT1_MOUSE Histone-lysine N-methyltransferase EHMT1 COMDA_MOUSE COMM domain-containing protein 10 CPSF7_MOUSE Cleavage and polyadenylation specificity factor subunit 7 GRB2_MOUSE Growth factor receptor-bound protein 2 RFIP5_MOUSE Rab11 family-interacting protein 5 NEUA_MOUSE N-acylneuraminate cytidylyltransferase BRE1A_MOUSE E3 ubiquitin-protein ligase BRE1A FIP1_MOUSE Pre-mRNA 3'-end-processing factor FIP1 VKORL_MOUSE Vitamin K epoxide reductase complex subunit 1-like protein 1 HOME1_MOUSE Homer protein homolog 1 MED10_MOUSE Mediator of RNA polymerase II transcription subunit 10 RIFK_MOUSE Riboflavin kinase PUM1_MOUSE Pumilio homolog 1 SC23B_MOUSE Protein transport protein Sec23B GPCP1_MOUSE Glycerophosphocholine phosphodiesterase GPCPD1 TBL1X_MOUSE F-box-like/WD repeat-containing protein TBL1X GSTA3_MOUSE Glutathione S-transferase A3 CCM2_MOUSE Malcavernin TMED3_MOUSE Transmembrane emp24 domain-containing protein 3 NCS1_MOUSE Neuronal calcium sensor 1 RM35_MOUSE 39S ribosomal protein L35, mitochondrial TGS1_MOUSE Trimethylguanosine synthase STABP_MOUSE STAM-binding protein DOCK9_MOUSE Dedicator of cytokinesis protein 9 GPT11_MOUSE G patch domain-containing protein 11 PAPD1_MOUSE Poly(A) RNA polymerase, mitochondrial MMAA_MOUSE Methylmalonic aciduria type A homolog, mitochondrial HABP4_MOUSE Intracellular hyaluronan-binding protein 4 E9PYH6_MOUSE Protein Setd1a SRXN1_MOUSE Sulfiredoxin-1 ST38L_MOUSE Serine/threonine-protein kinase 38-like E9Q9Q2_MOUSE Protein R3hdm1 SNX16_MOUSE Sorting nexin-16 BAP18_MOUSE Chromatin complexes subunit BAP18 CHAP1_MOUSE Chromosome alignment-maintaining phosphoprotein 1 WBP4_MOUSE WW domain-binding protein 4
EP
Npc1 Rbm7 Fkbpl Cnot3 Dnajc9 Stt3b Mkln1 Phf5a Cstf2t Xpo7 Sfswap Rbm4 Qpctl Rmdn3 Zfyve19 Ccdc104 Hp1bp3 Nt5dc3 Ifi205a Naa40 Wdr4
AC C
sp|O35604|NPC1_MOUSE sp|Q9CQT2|RBM7_MOUSE sp|O35450|FKBPL_MOUSE sp|Q8K0V4|CNOT3_MOUSE sp|Q91WN1|DNJC9_MOUSE sp|Q3TDQ1|STT3B_MOUSE sp|O89050|MKLN1_MOUSE sp|P83870|PHF5A_MOUSE sp|Q8C7E9|CSTFT_MOUSE sp|Q9EPK7|XPO7_MOUSE sp|Q3USH5|SFSWA_MOUSE sp|Q8C7Q4|RBM4_MOUSE sp|Q8BH73|QPCTL_MOUSE sp|Q3UJU9|RMD3_MOUSE sp|Q9DAZ9|ZFY19_MOUSE sp|Q8C6E0|CC104_MOUSE sp|Q3TEA8-2|HP1B3_MOUSE sp|Q3UHB1|NT5D3_MOUSE sp|Q8CGE8|IFI5A_MOUSE sp|Q8VE10|NAA40_MOUSE sp|Q9EP82|WDR4_MOUSE sp|A2AMZ4|CQ089_MOUSE sp|Q8BNU0|ARMC6_MOUSE sp|Q3TGF2|F107B_MOUSE sp|Q8BKU8|TM87B_MOUSE sp|Q9D211|C2AIL_MOUSE sp|Q5DW34|EHMT1_MOUSE sp|Q8JZY2|COMDA_MOUSE sp|Q8BTV2|CPSF7_MOUSE sp|Q60631|GRB2_MOUSE sp|Q8R361|RFIP5_MOUSE sp|Q99KK2|NEUA_MOUSE sp|Q5DTM8|BRE1A_MOUSE sp|Q9D824|FIP1_MOUSE sp|Q6TEK5|VKORL_MOUSE sp|Q9Z2Y3|HOME1_MOUSE sp|Q9CXU0|MED10_MOUSE sp|Q8CFV9|RIFK_MOUSE sp|Q80U78|PUM1_MOUSE sp|Q9D662|SC23B_MOUSE sp|Q8C0L9|GPCP1_MOUSE sp|Q9QXE7|TBL1X_MOUSE sp|P30115|GSTA3_MOUSE sp|Q8K2Y9|CCM2_MOUSE sp|Q78IS1|TMED3_MOUSE sp|Q8BNY6|NCS1_MOUSE sp|Q9CQL6|RM35_MOUSE sp|Q923W1|TGS1_MOUSE sp|Q9CQ26|STABP_MOUSE sp|Q8BIK4|DOCK9_MOUSE sp|Q3UFS4|GPT11_MOUSE sp|Q9D0D3|PAPD1_MOUSE sp|Q8C7H1|MMAA_MOUSE sp|Q9JKS5|HABP4_MOUSE tr|E9PYH6|E9PYH6_MOUSE sp|Q9D975|SRXN1_MOUSE sp|Q7TSE6|ST38L_MOUSE tr|E9Q9Q2|E9Q9Q2_MOUSE sp|Q8C080|SNX16_MOUSE sp|Q9DCT6|BAP18_MOUSE sp|Q8K327|CHAP1_MOUSE sp|Q61048|WBP4_MOUSE
101.837 84.8719 82.4176 86.9063 89.6281 161.218 123.246 55.6539 137.154 159.741 99.8434 53.1743 45.851 104.096 60.6289 48.3973 97.6435 93.6057 106.379 114.201 55.05 61.6584 94.1204 155.515 156.002 67.2284 113.224 122.074 176.28 190.815 69.9066 57.9037 94.9756 51.015 100.565 160.294 132.139 176.865 161.386 91.4373 54.9454 96.8483 54.1202 85.9157 171.519 87.9208 99.068 66.9682 65.5503 111.517 107.06 37.0256 62.3558 105.184 51.5422 99.1307 84.4569 64.678 40.5692 248.822 132.615 69.1257
170.454 103.173 73.7365 97.355 159.418 125.957 83.9736 94.1868 97.5026 165.332 114.987 63.1893 65.3695 366.918 49.0142 165.531 42.0048 103.169 25.1666 135.382 45.5557 59.8908 120.261 172.758 201.246 58.1762 154.108 129.345 151.199 166.07 124.672 282.13 70.9661 66.04 79.5094 177.729 91.6264 156.246 108.368 107.648 103.468 116.997 146.15 55.1722 106.196 83.9974 73.9436 93.5117 62.1147 92.416 157.782 74.7049 39.4563 52.9203 37.0295 105.04 102.606 57.2099 43.447 192.991 126.026 79.4734
102.22 150.891 162.631 123.679 209.172 106.428 151.313 236.13 170.265 115.908 162.611 116.276 35.8583 543.605 101.618 370.051 65.05 90.6629 33.0124 94.0203 42.5825 76.2584 102.153 351.726 113.288 109.185 227.977 137.256 137.775 311.587 166.913 249.836 126.506 124.7 99.1635 364.574 301.761 307.742 143.509 83.0119 115.841 250.987 553.937 98.5069 88.6123 125.659 255.89 111.318 95.5273 89.9948 256.404 61.7875 46.4295 131.618 54.0182 311.601 79.7899 168.286 68.3065 375.37 235.3 150.02
0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.93 0.93 0.93 0.93 0.93 0.93
1.03 1.50 1.12 1.04 2.06 0.85 1.10 2.59 0.95 0.92 1.23 1.50 0.95 4.05 1.11 4.71 0.46 0.91 0.24 0.85 0.76 0.90 1.17 1.50 0.84 1.21 1.54 0.91 0.71 1.15 2.03 3.93 0.86 1.52 1.03 1.54 1.40 1.07 0.76 1.04 1.83 1.81 5.77 0.73 0.64 1.03 1.70 1.40 0.90 0.95 1.63 1.44 0.44 0.71 0.72 2.17 1.03 1.47 1.19 0.94 1.27 1.18
ACCEPTED MANUSCRIPT
Csnk2a2 Decr2 Nkap Pnkp Rprd1b Tor1aip2
150.252 178.189 49.497 161.643 136.125 130.926 79.0185 96.8403 158.625 170.009 31.1295 140.043 198.946 163.69 71.6367 82.6843 115.956 98.449 39.5846 88.9499 73.3555 87.0827 91.105 148.958 46.6783 77.4788 158.567 77.1652 115.989 44.4674 104.376 103.777 90.0306 43.8957 70.8593 89.1221 92.4807 169.87 59.4854 169.989 78.991 117.661 113.524 115.01 131.499 95.6636 90.1287 87.9814 99.3047 103.756 83.403 93.5696 176.783 143.509 78.4537 182.827 84.6749 90.8978 75.1725 74.0666 120.974 83.7381
184.411 175.539 53.5045 149.551 128.914 112.843 86.6037 100.132 177.325 221.752 36.3742 94.8195 179.079 187.109 67.1676 61.9774 119.292 97.5417 44.1046 97.4063 61.4296 90.3008 68.2392 113.612 40.4958 84.1498 113.983 74.5249 131.923 46.0946 106.147 103.354 82.4488 45.3532 68.4451 89.6737 89.0337 125.699 54.5549 180.498 78.8416 115.7 120.407 85.6587 105.095 77.7769 78.6056 92.4344 84.3648 106.897 86.4503 144.969 146.051 137.093 83.7764 180.203 74.4645 75.2292 76.1388 77.7824 118.997 83.2348
RI PT
205.274 226.576 51.3335 147.068 135.05 116.342 97.8315 89.894 172.673 237.142 39.393 115.238 183.201 197.299 63.514 108.851 134.589 126.894 39.1617 131.781 59.8118 94.9788 73.5599 116.114 42.8989 86.0655 105.097 73.4285 122.51 50.2544 89.8427 107.378 90.1727 44.4336 59.9188 98.4151 93.3751 124.053 50.6392 173.193 81.0041 125.326 119.673 90.1328 150.876 112.814 81.8797 95.2006 107.254 120.382 101.152 185.82 209.392 159.052 91.7666 176.231 97.8976 91.6638 82.0525 76.8623 122.78 97.1795
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
TE D
Znf512b Gaa Ulk3 Mgrn1 Map3k2 Med7 Kctd5 Fam172a Rbm6 Zeb1 Stx18 Tprkb Pafah1b3 Dffa Polr2f Mapk8ip3 Dpf2 Ppp4c Pdcl Pdcl3 Tnip1 Atp6v1f Znf516 Arsk Gtf2f2 Gfer Snrpd1 Uqcc1 Max Tp53bp2 Ccdc93 Nt5c3b Ctbp2 Add1 Nxn Nptn Cr1l
Q6XPS7_MOUSE L-threonine aldolase CPSF1_MOUSE Cleavage and polyadenylation specificity factor subunit 1 ZHX1_MOUSE Zinc fingers and homeoboxes protein 1 CHM2B_MOUSE Charged multivesicular body protein 2b IFT27_MOUSE Intraflagellar transport protein 27 homolog BCAR3_MOUSE Breast cancer anti-estrogen resistance protein 3 VPS28_MOUSE Vacuolar protein sorting-associated protein 28 homolog RU1C_MOUSE U1 small nuclear ribonucleoprotein C RABX5_MOUSE Rab5 GDP/GTP exchange factor TPC13_MOUSE Trafficking protein particle complex subunit 13 MCU_MOUSE Calcium uniporter protein, mitochondrial YTHD2_MOUSE YTH domain-containing family protein 2 STAR7_MOUSE StAR-related lipid transfer protein 7, mitochondrial PRP4_MOUSE U4/U6 small nuclear ribonucleoprotein Prp4 NDEL1_MOUSE Nuclear distribution protein nudE-like 1 CP1B1_MOUSE Cytochrome P450 1B1 KS6A4_MOUSE Ribosomal protein S6 kinase alpha-4 CT027_MOUSE UPF0687 protein C20orf27 homolog B7ZCR6_MOUSE Protein Znf512b LYAG_MOUSE Lysosomal alpha-glucosidase ULK3_MOUSE Serine/threonine-protein kinase ULK3 MGRN1_MOUSE E3 ubiquitin-protein ligase MGRN1 M3K2_MOUSE Mitogen-activated protein kinase kinase kinase 2 MED7_MOUSE Mediator of RNA polymerase II transcription subunit 7 KCTD5_MOUSE BTB/POZ domain-containing protein KCTD5 F172A_MOUSE Protein FAM172A Q3ULB0_MOUSE Protein Rbm6 ZEB1_MOUSE Zinc finger E-box-binding homeobox 1 STX18_MOUSE Syntaxin-18 TPRKB_MOUSE EKC/KEOPS complex subunit Tprkb PA1B3_MOUSE Platelet-activating factor acetylhydrolase IB subunit gamma DFFA_MOUSE Isoform ICAD-S of DNA fragmentation factor subunit alpha RPAB2_MOUSE DNA-directed RNA polymerases I, II, and III subunit RPABC2 JIP3_MOUSE C-Jun-amino-terminal kinase-interacting protein 3 REQU_MOUSE Zinc finger protein ubi-d4 PP4C_MOUSE Serine/threonine-protein phosphatase 4 catalytic subunit PHLP_MOUSE Phosducin-like protein PDCL3_MOUSE Phosducin-like protein 3 TNIP1_MOUSE TNFAIP3-interacting protein 1 VATF_MOUSE V-type proton ATPase subunit F ZN516_MOUSE Zinc finger protein 516 ARSK_MOUSE Arylsulfatase K T2FB_MOUSE General transcription factor IIF subunit 2 ALR_MOUSE FAD-linked sulfhydryl oxidase ALR SMD1_MOUSE Small nuclear ribonucleoprotein Sm D1 UQCC1_MOUSE Ubiquinol-cytochrome-c reductase complex assembly factor 1 MAX_MOUSE Protein max ASPP2_MOUSE Apoptosis-stimulating of p53 protein 2 CCD93_MOUSE Coiled-coil domain-containing protein 93 5NT3B_MOUSE 7-methylguanosine phosphate-specific 5'-nucleotidase CTBP2_MOUSE C-terminal-binding protein 2 ADDA_MOUSE Alpha-adducin NXN_MOUSE Nucleoredoxin NPTN_MOUSE Neuroplastin CR1L_MOUSE Complement component receptor 1-like protein CA122_MOUSE Uncharacterized protein C1orf122 homolog CSK22_MOUSE Casein kinase II subunit alpha' DECR2_MOUSE Peroxisomal 2,4-dienoyl-CoA reductase NKAP_MOUSE NF-kappa-B-activating protein PNKP_MOUSE Bifunctional polynucleotide phosphatase/kinase RPR1B_MOUSE Regulation of nuclear pre-mRNA domain-containing protein 1B TOIP2_MOUSE Torsin-1A-interacting protein 2
EP
Tha1 Cpsf1 Zhx1 Chmp2b Ift27 Bcar3 Vps28 Snrpc Rabgef1 Trappc13 Mcu Ythdf2 Stard7 Prpf4 Ndel1 Cyp1b1 Rps6ka4
AC C
tr|Q6XPS7|Q6XPS7_MOUSE sp|Q9EPU4|CPSF1_MOUSE sp|P70121|ZHX1_MOUSE sp|Q8BJF9|CHM2B_MOUSE sp|Q9D0P8|IFT27_MOUSE sp|Q9QZK2|BCAR3_MOUSE sp|Q9D1C8|VPS28_MOUSE sp|Q62241|RU1C_MOUSE sp|Q9JM13|RABX5_MOUSE sp|Q3TIR1|TPC13_MOUSE sp|Q3UMR5|MCU_MOUSE sp|Q91YT7|YTHD2_MOUSE sp|Q8R1R3|STAR7_MOUSE sp|Q9DAW6|PRP4_MOUSE sp|Q9ERR1|NDEL1_MOUSE sp|Q64429|CP1B1_MOUSE sp|Q9Z2B9|KS6A4_MOUSE sp|Q9D1K7|CT027_MOUSE tr|B7ZCR6|B7ZCR6_MOUSE sp|P70699|LYAG_MOUSE sp|Q3U3Q1|ULK3_MOUSE sp|Q9D074|MGRN1_MOUSE sp|Q61083|M3K2_MOUSE sp|Q9CZB6|MED7_MOUSE sp|Q8VC57|KCTD5_MOUSE sp|Q3TNH5|F172A_MOUSE tr|Q3ULB0|Q3ULB0_MOUSE sp|Q64318|ZEB1_MOUSE sp|Q8VDS8|STX18_MOUSE sp|Q8QZZ7|TPRKB_MOUSE sp|Q61205|PA1B3_MOUSE sp|O54786-2|DFFA_MOUSE sp|P61219|RPAB2_MOUSE sp|Q9ESN9|JIP3_MOUSE sp|Q61103|REQU_MOUSE sp|P97470|PP4C_MOUSE sp|Q9DBX2|PHLP_MOUSE sp|Q8BVF2|PDCL3_MOUSE sp|Q9WUU8|TNIP1_MOUSE sp|Q9D1K2|VATF_MOUSE sp|Q7TSH3|ZN516_MOUSE sp|Q9D2L1|ARSK_MOUSE sp|Q8R0A0|T2FB_MOUSE sp|P56213|ALR_MOUSE sp|P62315|SMD1_MOUSE sp|Q9CWU6|UQCC1_MOUSE sp|P28574|MAX_MOUSE sp|Q8CG79|ASPP2_MOUSE sp|Q7TQK5|CCD93_MOUSE sp|Q3UFY7|5NT3B_MOUSE sp|P56546|CTBP2_MOUSE sp|Q9QYC0|ADDA_MOUSE sp|P97346|NXN_MOUSE sp|P97300|NPTN_MOUSE sp|Q64735|CR1L_MOUSE sp|B1ARW8|CA122_MOUSE sp|O54833|CSK22_MOUSE sp|Q9WV68|DECR2_MOUSE sp|Q9D0F4|NKAP_MOUSE sp|Q9JLV6|PNKP_MOUSE sp|Q9CSU0|RPR1B_MOUSE sp|Q8BYU6|TOIP2_MOUSE
146.571 201.279 40.3628 137.59 123.256 116.606 77.3022 72.5772 128.798 154.353 28.7379 140.577 173.164 145.588 56.8535 113.466 110.192 108.1 27.7241 103.932 60.0112 75.5898 81.7303 127.503 40.9386 64.4147 125.526 62.245 84.6556 39.7978 69.6431 87.7392 80.2859 34.3823 49.5789 79.4507 78.4922 139.098 44.6331 128.361 64.9036 102.514 88.663 98.2519 147.421 108.639 75.1578 70.8646 99.6399 92.6509 77.7163 102.953 196.173 130.671 66.7338 136.659 86.4866 85.6378 62.2795 54.6531 94.8464 75.3317
74.2861 167.583 35.6947 79.5061 101.098 80.9678 72.3152 74.449 155.623 180.506 61.587 113.34 134.642 190.826 52.364 25.6255 93.0366 51.924 24.771 39.2233 131.41 45.1791 70.5146 84.4978 39.3018 61.0993 119.785 44.4073 106.473 42.6001 113.725 59.6469 65.7515 99.7955 63.3047 39.8685 81.5521 174.272 25.7704 87.4266 129.096 59.2756 114.944 87.5642 96.0089 138.096 38.9636 69.0672 84.7711 95.5257 71.3432 76.2632 220.658 125.091 72.0237 31.9254 83.8009 118.679 58.016 120.695 108.392 81.1782
184.76 157.904 91.1124 135.184 243.684 126.755 89.4785 242.86 197.207 201.28 22.9295 132.754 234.835 226.157 89.3168 45.7129 75.3181 90.6746 51.1078 65.0721 168.217 45.3568 78.8007 163.043 46.8515 71.9459 276.263 75.5446 152.082 43.6304 135.338 108.673 140.694 105.494 107.137 59.8851 135.939 365.754 44.4596 190.135 203.882 117.613 170.9 186.512 84.4245 101.272 134.955 153.741 82.5166 97.4924 72.509 102.471 163.753 154.511 76.3948 117.429 62.9369 145.612 137.652 142.579 153.603 78.0804
0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88
0.73 0.80 1.26 0.70 1.27 0.84 0.91 1.70 1.06 0.94 1.20 0.96 0.97 1.16 1.05 0.37 0.67 0.63 0.96 0.47 2.25 0.50 0.91 0.93 0.96 0.81 1.50 0.80 1.08 0.91 1.28 0.80 1.15 2.32 1.30 0.53 1.17 1.84 0.64 0.81 2.08 0.73 1.23 1.34 0.64 1.15 1.01 1.22 0.81 0.86 0.78 0.64 1.00 0.92 0.87 0.42 0.80 1.45 1.24 1.74 1.07 0.88
ACCEPTED MANUSCRIPT
49.0077 169.578 55.3133 78.2997 98.7341 192.147 147.395 77.1841 76.7499 239.119 98.9307 100.562 74.0371 228.115 130.827 100.498 177.442 151.074 126.112 51.7852 192.139 155.026 78.9504 87.2183 164.232 74.7189 58.5577 75.3006 130.151 123.815 135.407 80.9954 242.886 68.9214 108.74 291.02 122.123 123.134 112.411 77.8416 143.862 142.808 164.135 171.407 112.354 120.017 239.593 117.527 217.902 77.5379 138.361 223.761 87.1995 111.771 161.788 175.671 63.4987 79.0754 110.586 96.0215 135.529 111.46
45.1856 140.045 53.7918 61.0728 107.782 183.576 116.007 92.1709 46.5883 213.728 95.208 94.7792 59.7612 154.485 120.083 88.4183 210.699 132.772 48.8878 50.5307 166.272 115.421 80.1249 96.0227 140.13 51.7437 56.2118 80.2808 119.292 100.864 116.46 60.3304 231.226 72.584 106.975 183.768 122.11 97.8884 99.9329 68.7451 117.057 107.267 152.005 139.158 99.116 92.204 221.556 98.8907 187.188 53.3993 93.1403 182.645 73.293 93.0547 160.221 157.576 67.9354 72.0098 98.5888 76.6743 104.128 95.4465
RI PT
SC
M AN U
TE D
Ube2b Hddc3 Pxdn Pygo2 Jund Whsc1l1 Stxbp2 Nfic Trappc2 Dopey2 Acbd6 Eif4ebp2 Snx27 Ikbip Dda1 Atf7ip Vps51 Guk1 Tpd52 Ogfod1 Cav2 Mbd2 Ube2g1 Chmp3 Stx17 Irf3 Fnbp1l Pfn2 Cdc23 Tbl1xr1 Col8a1 Srsf3 Gm16286 Plod2 Cpne3 Art3 Ankrd49 Strn3 Wasl Pisd Efhd2
BCKD_MOUSE [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2 55.2729 RBMS2_MOUSE RNA-binding motif, single-stranded-interacting protein 2 2 135.619 UBE2Z_MOUSE Ubiquitin-conjugating enzyme E2 Z 2 53.7816 PTEN_MOUSE Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase 2 PTEN 74.6091 PDP1_MOUSE [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial 2 130.838 G3UVU2_MOUSE Splicing factor 3A subunit 2 2 205.325 SON_MOUSE Protein SON 2 131.04 NF1_MOUSE Neurofibromin 2 98.6315 TMM33_MOUSE Transmembrane protein 33 2 84.2241 SFR1_MOUSE Swi5-dependent recombination DNA repair protein 1 homolog 2 193.11 ARHL2_MOUSE Poly(ADP-ribose) glycohydrolase ARH3 2 104.451 LTOR1_MOUSE Ragulator complex protein LAMTOR1 2 98.04 NDUS6_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial 2 61.5454 S4R2E2_MOUSE Protein PRRC2C (Fragment) 2 110.583 EOGT_MOUSE EGF domain-specific O-linked N-acetylglucosamine transferase 2 152.961 SMU1_MOUSE WD40 repeat-containing protein SMU1 2 115.763 E9PY42_MOUSE Protein Eci3 (Fragment) 2 196.844 THOC6_MOUSE THO complex subunit 6 homolog 2 162.457 TM135_MOUSE Transmembrane protein 135 2 116.671 F7CVJ5_MOUSE Protein Ahnak2 (Fragment) 2 45.94 ASHWN_MOUSE Ashwin 2 181.255 UBE2B_MOUSE Ubiquitin-conjugating enzyme E2 B 2 115.193 MESH1_MOUSE Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 2 78.2729 PXDN_MOUSE Peroxidasin homolog 2 98.0476 Q80V76_MOUSE Protein Pygo2 2 132.193 JUND_MOUSE Transcription factor jun-D 2 46.93 NSD3_MOUSE Histone-lysine N-methyltransferase NSD3 2 57.2488 STXB2_MOUSE Syntaxin-binding protein 2 2 100.141 NFIC_MOUSE Nuclear factor 1 C-type 2 163.979 TPPC2_MOUSE Trafficking protein particle complex subunit 2 2 152.077 DOP2_MOUSE Protein dopey-2 2 100.156 ACBD6_MOUSE Acyl-CoA-binding domain-containing protein 6 2 60.5405 4EBP2_MOUSE Eukaryotic translation initiation factor 4E-binding protein 2 2 245.505 SNX27_MOUSE Sorting nexin-27 2 92.6277 IKIP_MOUSE Inhibitor of nuclear factor kappa-B kinase-interacting protein 2 119.708 DDA1_MOUSE DET1- and DDB1-associated protein 1 2 185.071 MCAF1_MOUSE Activating transcription factor 7-interacting protein 1 2 160.353 VPS51_MOUSE Vacuolar protein sorting-associated protein 51 homolog 2 146.264 KGUA_MOUSE Guanylate kinase 2 98.8484 TPD52_MOUSE Tumor protein D52 2 68.3608 OGFD1_MOUSE Prolyl 3-hydroxylase OGFOD1 2 137.765 CAV2_MOUSE Caveolin-2 2 165.828 MBD2_MOUSE Methyl-CpG-binding domain protein 2 2 165.463 UB2G1_MOUSE Ubiquitin-conjugating enzyme E2 G1 2 142.855 CHMP3_MOUSE Charged multivesicular body protein 3 2 108.577 STX17_MOUSE Syntaxin-17 2 121.114 IRF3_MOUSE Interferon regulatory factor 3 2 244.011 FBP1L_MOUSE Formin-binding protein 1-like 2 105.255 PROF2_MOUSE Profilin-2 2 217.213 CDC23_MOUSE Cell division cycle protein 23 homolog 2 76.9202 TBL1R_MOUSE F-box-like/WD repeat-containing protein TBL1XR1 2 115.731 CO8A1_MOUSE Collagen alpha-1(VIII) chain 2 228.796 SRSF3_MOUSE Serine/arginine-rich splicing factor 3 2 90.7966 Q9CQX6_MOUSE MCG141091, isoform CRA_a 2 110.988 PLOD2_MOUSE Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 2 185.814 CPNE3_MOUSE Copine-3 2 177.041 NAR3_MOUSE Ecto-ADP-ribosyltransferase 3 2 74.9439 ANR49_MOUSE Ankyrin repeat domain-containing protein 49 2 78.6871 STRN3_MOUSE Striatin-3 2 136.183 WASL_MOUSE Neural Wiskott-Aldrich syndrome protein 2 96.1028 PISD_MOUSE Phosphatidylserine decarboxylase proenzyme 2 126.805 EFHD2_MOUSE EF-hand domain-containing protein D2 2 103.528
EP
Bckdk Rbms2 Ube2z Pten Pdp1 Sf3a2 Son Nf1 Tmem33 Sfr1 Adprhl2 Lamtor1 Ndufs6 Prrc2c Eogt Smu1 Eci3 Thoc6 Tmem135 Ahnak2
AC C
sp|O55028|BCKD_MOUSE sp|Q8VC70|RBMS2_MOUSE sp|Q3UE37|UBE2Z_MOUSE sp|O08586|PTEN_MOUSE sp|Q3UV70|PDP1_MOUSE tr|G3UVU2|G3UVU2_MOUSE sp|Q9QX47|SON_MOUSE sp|Q04690|NF1_MOUSE sp|Q9CR67|TMM33_MOUSE sp|Q8BP27|SFR1_MOUSE sp|Q8CG72|ARHL2_MOUSE sp|Q9CQ22|LTOR1_MOUSE sp|P52503|NDUS6_MOUSE tr|S4R2E2|S4R2E2_MOUSE sp|Q8BYW9|EOGT_MOUSE sp|Q3UKJ7|SMU1_MOUSE tr|E9PY42|E9PY42_MOUSE sp|Q5U4D9|THOC6_MOUSE sp|Q9CYV5|TM135_MOUSE tr|F7CVJ5|F7CVJ5_MOUSE sp|Q922M7|ASHWN_MOUSE sp|P63147|UBE2B_MOUSE sp|Q9D114|MESH1_MOUSE sp|Q3UQ28|PXDN_MOUSE tr|Q80V76|Q80V76_MOUSE sp|P15066|JUND_MOUSE sp|Q6P2L6|NSD3_MOUSE sp|Q64324|STXB2_MOUSE sp|P70255|NFIC_MOUSE sp|Q9CQP2|TPPC2_MOUSE sp|Q3UHQ6|DOP2_MOUSE sp|Q9D061|ACBD6_MOUSE sp|P70445|4EBP2_MOUSE sp|Q3UHD6|SNX27_MOUSE sp|Q9DBZ1|IKIP_MOUSE sp|Q9D9Z5|DDA1_MOUSE sp|Q7TT18|MCAF1_MOUSE sp|Q3UVL4|VPS51_MOUSE sp|Q64520|KGUA_MOUSE sp|Q62393|TPD52_MOUSE sp|Q3U0K8|OGFD1_MOUSE sp|Q9WVC3|CAV2_MOUSE sp|Q9Z2E1|MBD2_MOUSE sp|P62254|UB2G1_MOUSE sp|Q9CQ10|CHMP3_MOUSE sp|Q9D0I4|STX17_MOUSE sp|P70671|IRF3_MOUSE sp|Q8K012|FBP1L_MOUSE sp|Q9JJV2|PROF2_MOUSE sp|Q8BGZ4|CDC23_MOUSE sp|Q8BHJ5|TBL1R_MOUSE sp|Q00780|CO8A1_MOUSE sp|P84104|SRSF3_MOUSE tr|Q9CQX6|Q9CQX6_MOUSE sp|Q9R0B9|PLOD2_MOUSE sp|Q8BT60|CPNE3_MOUSE sp|Q8R2G4|NAR3_MOUSE sp|Q8VE42|ANR49_MOUSE sp|Q9ERG2|STRN3_MOUSE sp|Q91YD9|WASL_MOUSE sp|Q8BSF4|PISD_MOUSE sp|Q9D8Y0|EFHD2_MOUSE
46.1423 126.894 41.5657 72.0381 91.9923 161.691 125.813 59.8307 92.3814 158.927 79.7615 75.7187 56.4632 135.218 122.591 96.3915 108.403 134.372 157.437 32.5173 150.963 113.984 53.1382 60.8926 110.032 50.7618 41.203 67.1781 127.877 130.728 80.9128 58.1941 177.753 62.2788 83.4715 212.746 112.782 126.019 75.5621 51.4477 114.148 146.03 118.485 118.746 81.9193 105.041 173.859 82.6826 166.232 71.6663 111.683 179.831 68.9657 84.5924 116.952 120.431 40.8694 51.5159 93.8806 72.6362 99.2612 70.1889
172.762 72.8765 44.504 57.31 120.273 149.99 225.541 73.6336 79.7187 33.8144 388.047 59.9846 63.5119 16.6125 138.022 126.231 167.766 193.112 75 3.5391 59.397 132.518 25.1922 22.2671 52.9824 39.5927 33.4476 64.6076 151.691 121.793 178.326 42.3611 68.7615 91.5788 73.9043 42.5005 109.146 78.8882 107.017 29.2054 96.7979 182.236 89.8398 143.4 87.4064 108.589 184.04 115.713 173.851 59.3442 142.655 164.865 63.7732 98.4493 328.682 195.483 4.26074 41.2563 49.3503 86.8095 65.797 88.1764
122.101 341.27 45.8271 111.864 96.4856 216.407 475.996 166.544 102.54 122.087 566.195 88.5815 101.498 23.6615 112.767 83.0292 285.801 218.695 74.51 0.0364659 104.856 245.159 65.3519 74.2908 89.3398 27.1809 58.4554 97.568 195.772 119.017 658.491 116.174 358.455 92.4325 58.2633 99.5997 148.97 94.7431 163.039 51.6364 131.694 118.301 181.225 304.889 127.31 219.24 214.37 219.041 267.803 56.7705 334.339 115.607 218.402 180.848 99.5617 137.092 12.0942 132.331 96.7552 106.283 206.252 161.969
0.88 0.87 0.87 0.87 0.87 0.87 0.87 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.85 0.85 0.85 0.85 0.85 0.85 0.85 0.85 0.85 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.83 0.83 0.83 0.83 0.83 0.83 0.82 0.82 0.82 0.82 0.82 0.82 0.82 0.82 0.82 0.81 0.81 0.81 0.80 0.80 0.80 0.80 0.79 0.79 0.78 0.78 0.78 0.78 0.77
2.83 1.36 0.83 1.11 0.94 0.92 2.52 1.37 1.13 0.36 4.69 0.75 1.22 0.12 0.88 0.97 1.21 1.31 0.62 0.04 0.44 1.40 0.58 0.52 0.48 0.55 0.79 0.92 1.18 0.87 3.55 1.12 0.87 1.14 0.58 0.30 0.91 0.64 1.28 0.55 0.81 0.97 0.82 1.43 0.97 1.36 0.82 1.50 1.02 0.75 1.88 0.62 1.59 1.25 1.23 0.94 0.12 1.10 0.59 1.01 1.04 1.16
ACCEPTED MANUSCRIPT
131.45 89.9409 282.067 73.7895 107.562 125.468 84.7939 284.219 84.7119 30.5878 69.2599 141.97 141.286 150.019 97.689 179.313 196.741 129.898 73.7723 83.461 79.7378 165.571 62.6403 640.215 0.0301103 29.7645 23.5214 13.6813 11.3419 125.978 29.569 26.0266 23.0133 17.9483 0 35.1574 93.8874 36.1027 35.923 29.9235 44.3761 115.026 45.7586 34.5581 24.1747 37.4457 65.5619 99.7439 43.9192 16.2747 26.1767 55.7425 17.2413 24.2936 2.28585 41.2517 31.9912 214.548 45.5067 34.9158 32.4318 29.5762
92.4211 69.3482 195.412 54.3571 68.2731 102.225 55.2438 130.907 64.4414 27.0592 54.428 75.8016 57.5279 131.092 51.7719 96.7976 148.147 119.292 44.155 62.626 63.2446 103.293 77.5058 253.345 0 39.1433 99.1109 37.014 42.6832 134.171 94.5174 36.6594 22.7613 52.1139 5.09622 98.7117 155.14 90.1237 74.6393 66.5068 48.6572 202.823 19.5552 76.3119 58.8744 93.0361 141.681 173.717 95.9453 43.992 63.8334 111.749 33.8477 45.7741 4.32644 71.7126 62.2655 408.834 90.3249 71.7792 28.5397 52.1664
RI PT
117.72 74.7987 325.822 73.9886 118.935 135.811 78.8548 261.667 91.2099 40.2352 64.7035 198.328 41.4485 176.444 92.3124 142.762 214.132 158.486 27.6734 114.792 86.798 178.24 165.69 5.49481 0.00111583 18.8251 26.7618 10.0858 15.4114 54.3439 32.6507 22.5881 17.7934 18.2058 3.26424 42.304 73.2065 41.5263 35.2154 36.5867 14.477 98.3206 13.4801 51.5303 30.5753 47.9351 72.3372 71.7487 52.4128 21.4157 39.8268 64.292 17.712 24.1193 3.50443 33.5113 42.5499 237.326 45.1808 48.8126 16.2705 28.5302
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
TE D
Tspan14 Setx Naa20 Cdk6 Tia1 Ubtf Hspd1 Evpl Cwc22 Pawr Mcm5 Mrps17 Ndufa3 Rab32 Acbd4 Zwilch Mrps16 Gclm Enpp2 Tdrd7 Eif4e3 Prim1 Tm7sf2 Hmgcr Ndufa6 Cd164 Antxr1 Farp1 Pnpla6 Gbp9 Cebpzos Ift81 Tmco3 Ppp1r3d Rbpms2 Nup188 Rcn3 Zmynd8 H2afy Rfc3 Mxra7 Ccdc167 Cacnb3 Chmp6 Dcn
RDH12_MOUSE Retinol dehydrogenase 12 BL1S6_MOUSE Biogenesis of lysosome-related organelles complex 1 subunit 6 COA7_MOUSE Cytochrome c oxidase assembly factor 7 HINT3_MOUSE Histidine triad nucleotide-binding protein 3 GLTP_MOUSE Glycolipid transfer protein GPX1_MOUSE Glutathione peroxidase 1 RBX1_MOUSE E3 ubiquitin-protein ligase RBX1 KISHA_MOUSE Protein kish-A ITPK1_MOUSE Inositol-tetrakisphosphate 1-kinase TRIPC_MOUSE E3 ubiquitin-protein ligase TRIP12 ZKSC3_MOUSE Zinc finger protein with KRAB and SCAN domains 3 NDUAB_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 XPO5_MOUSE Exportin-5 SPS2_MOUSE Selenide, water dikinase 2 JAGN1_MOUSE Protein jagunal homolog 1 TFEB_MOUSE Transcription factor EB CB076_MOUSE UPF0538 protein C2orf76 homolog TSN14_MOUSE Tetraspanin-14 SETX_MOUSE Probable helicase senataxin NAA20_MOUSE N-alpha-acetyltransferase 20 CDK6_MOUSE Cyclin-dependent kinase 6 TIA1_MOUSE Nucleolysin TIA-1 UBF1_MOUSE Nucleolar transcription factor 1 D3Z7J9_MOUSE 60 kDa heat shock protein, mitochondrial (Fragment) EVPL_MOUSE Envoplakin CWC22_MOUSE Pre-mRNA-splicing factor CWC22 homolog PAWR_MOUSE PRKC apoptosis WT1 regulator protein MCM5_MOUSE DNA replication licensing factor MCM5 RT17_MOUSE 28S ribosomal protein S17, mitochondrial NDUA3_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 RAB32_MOUSE Ras-related protein Rab-32 A2AHR2_MOUSE Protein Acbd4 H3BKB9_MOUSE Protein zwilch homolog (Fragment) RT16_MOUSE 28S ribosomal protein S16, mitochondrial GSH0_MOUSE Glutamate--cysteine ligase regulatory subunit ENPP2_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 TDRD7_MOUSE Tudor domain-containing protein 7 IF4E3_MOUSE Eukaryotic translation initiation factor 4E type 3 PRI1_MOUSE DNA primase small subunit ERG24_MOUSE Delta(14)-sterol reductase HMDH_MOUSE 3-hydroxy-3-methylglutaryl-coenzyme A reductase NDUA6_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 MUC24_MOUSE Sialomucin core protein 24 ANTR1_MOUSE Anthrax toxin receptor 1 FARP1_MOUSE FERM, RhoGEF and pleckstrin domain-containing protein 1 PLPL6_MOUSE Neuropathy target esterase Q8BTS3_MOUSE Guanylate-binding protein 9 Q8BTE5_MOUSE Uncharacterized protein IFT81_MOUSE Intraflagellar transport protein 81 homolog TMCO3_MOUSE Transmembrane and coiled-coil domain-containing protein 3 A2AJW4_MOUSE Protein phosphatase 1 regulatory subunit 3 RBPS2_MOUSE RNA-binding protein with multiple splicing 2 NU188_MOUSE Nucleoporin NUP188 homolog RCN3_MOUSE Reticulocalbin-3 A2A482_MOUSE Protein Zmynd8 H2AY_MOUSE Core histone macro-H2A.1 RFC3_MOUSE Replication factor C subunit 3 MXRA7_MOUSE Matrix-remodeling-associated protein 7 CC167_MOUSE Coiled-coil domain-containing protein 167 CACB3_MOUSE Voltage-dependent L-type calcium channel subunit beta-3 CHMP6_MOUSE Charged multivesicular body protein 6 PGS2_MOUSE Decorin
EP
Rdh12 Bloc1s6 Coa7 Hint3 Gltp Gpx1 Rbx1 Tmem167a Itpk1 Trip12 Zkscan3 Ndufa11 Xpo5 Sephs2 Jagn1 Tfeb
AC C
sp|Q8BYK4|RDH12_MOUSE sp|Q9R0C0|BL1S6_MOUSE sp|Q921H9|COA7_MOUSE sp|Q9CPS6|HINT3_MOUSE sp|Q9JL62|GLTP_MOUSE sp|P11352|GPX1_MOUSE sp|P62878|RBX1_MOUSE sp|Q9CR64|KISHA_MOUSE sp|Q8BYN3|ITPK1_MOUSE sp|G5E870|TRIPC_MOUSE sp|Q91VW9|ZKSC3_MOUSE sp|Q9D8B4|NDUAB_MOUSE sp|Q924C1|XPO5_MOUSE sp|P97364|SPS2_MOUSE sp|Q5XKN4|JAGN1_MOUSE sp|Q9R210|TFEB_MOUSE sp|Q9CRW3|CB076_MOUSE sp|Q8QZY6|TSN14_MOUSE sp|A2AKX3|SETX_MOUSE sp|P61600|NAA20_MOUSE sp|Q64261|CDK6_MOUSE sp|P52912|TIA1_MOUSE sp|P25976|UBF1_MOUSE tr|D3Z7J9|D3Z7J9_MOUSE sp|Q9D952|EVPL_MOUSE sp|Q8C5N3|CWC22_MOUSE sp|Q925B0|PAWR_MOUSE sp|P49718|MCM5_MOUSE sp|Q9CQE3|RT17_MOUSE sp|Q9CQ91|NDUA3_MOUSE sp|Q9CZE3|RAB32_MOUSE tr|A2AHR2|A2AHR2_MOUSE tr|H3BKB9|H3BKB9_MOUSE sp|Q9CPX7|RT16_MOUSE sp|O09172|GSH0_MOUSE sp|Q9R1E6|ENPP2_MOUSE sp|Q8K1H1|TDRD7_MOUSE sp|Q9DBB5|IF4E3_MOUSE sp|P20664|PRI1_MOUSE sp|Q71KT5|ERG24_MOUSE sp|Q01237|HMDH_MOUSE sp|Q9CQZ5|NDUA6_MOUSE sp|Q9R0L9|MUC24_MOUSE sp|Q9CZ52|ANTR1_MOUSE sp|F8VPU2|FARP1_MOUSE sp|Q3TRM4|PLPL6_MOUSE tr|Q8BTS3|Q8BTS3_MOUSE tr|Q8BTE5|Q8BTE5_MOUSE sp|O35594|IFT81_MOUSE sp|Q8BH01|TMCO3_MOUSE tr|A2AJW4|A2AJW4_MOUSE sp|Q8VC52|RBPS2_MOUSE sp|Q6ZQH8|NU188_MOUSE sp|Q8BH97|RCN3_MOUSE tr|A2A482|A2A482_MOUSE sp|Q9QZQ8|H2AY_MOUSE sp|Q8R323|RFC3_MOUSE sp|Q9CZH7|MXRA7_MOUSE sp|Q9D162|CC167_MOUSE sp|P54285|CACB3_MOUSE sp|P0C0A3|CHMP6_MOUSE sp|P28654|PGS2_MOUSE
99.1715 57.0487 270.685 58.1627 104.106 94.2375 67.3552 276.633 66.3436 25.2155 44.3976 175.056 76.2343 107.221 86.5976 137.519 149.039 87.053 27.0517 71.3006 48.0035 120.081 62.6655 3.49984 0 128.535 60.4929 29.259 25.6911 317.912 61.1778 81.414 75.6323 32.979 2.05626 70.3596 185.658 64.4045 61.5013 58.6339 61.8725 197.172 90.521 82.6964 37.8532 57.4864 100.14 124.7 70.1817 19.9259 47.8714 88.9016 24.198 33.6589 5.09198 49.6295 58.5909 320.639 55.7976 62.6087 49.4201 40.3516
91.9931 38.353 248.74 66.3951 102.719 96.0832 99.4374 245.283 243.59 139.815 30.4812 102.816 62.6704 124.839 105.962 71.5148 111.104 96.4897 265.895 80.6347 92.112 119.495 133.712 165.644 745.255 65.5117 32.5003 34.2205 155.502 186.368 37.7098 44.2244 8.20438 97.3569 80.9935 122.851 84.1561 104.386 55.4505 11.6944 27.1103 168.324 30.5312 29.0251 63.9576 0 74.2106 114.939 53.6873 30.774 30.6906 25.577 26.6523 12.3018 93.6433 57.8708 34.005 437.96 52.788 38.8746 3.22211 13.8015
41.9367 101.819 279.597 92.3632 104.111 191.901 148.655 302.531 288.8 174.465 64.5354 115.358 77.1645 155.505 109.968 244.247 201.978 128.043 179.559 78.5555 100.484 367.755 179.333 14.8887 394.174 39.8357 58.7929 14.9302 173.328 80.1252 29.9406 19.7906 8.52624 149.692 94.6887 93.4234 70.8702 86.6643 45.9156 7.10403 19.6973 120.793 29.5344 34.9443 69.2227 0.133135 55.5522 140.152 47.6378 38.1128 36.1973 99.6962 16.0157 24.7276 242.988 3.6732 57.2877 264.114 48.798 38.5035 10.0437 22.2092
0.77 0.77 0.77 0.76 0.76 0.75 0.75 0.75 0.74 0.74 0.74 0.74 0.73 0.73 0.73 0.73 0.72 0.72 0.70 0.68 0.67 0.65 0.61 0.40 0.00 3.45 3.17 2.79 2.56 2.51 2.50 2.43 2.41 2.35 2.19 2.18 2.04 1.99 1.91 1.88 1.88 1.87 1.86 1.85 1.77 1.76 1.75 1.74 1.72 1.70 1.69 1.67 1.66 1.64 1.63 1.62 1.62 1.61 1.61 1.61 1.60 1.59
0.54 0.85 0.87 1.07 0.91 1.10 1.52 1.00 3.03 4.44 0.71 0.64 0.77 0.86 1.14 0.98 0.76 0.78 4.39 0.80 1.16 1.42 1.37 0.28 36489.60 2.17 1.82 2.07 12.29 1.48 1.09 1.32 0.41 6.83 53.82 2.79 0.93 2.46 1.42 0.28 0.80 1.36 1.01 0.74 2.43 0.00 0.94 1.49 1.05 1.83 1.01 1.04 1.22 0.76 58.14 0.82 1.22 1.55 1.12 0.92 0.27 0.62
ACCEPTED MANUSCRIPT
TE D
71.8065 59.2919 23.3713 25.8693 54.2603 19.4172 20.0156 7.29683 11.8063 21.6719 25.1046 15.9172 28.4232 41.3256 37.3026 71.9384 42.5178 21.0323 52.5702 78.4119 58.8733 20.9306 62.7248 52.2815 33.9678 55.5955 27.634 75.3326 35.1442 22.433 29.2837 126.978 69.4294 57.8536 23.5762 21.3065 35.7026 46.6317 26.1241 19.3547 52.9509 76.5861 192.806 25.9028 13.3917 22.5769 56.505 6.49863 35.3786 37.5485 74.3065 62.7008 44.7095 24.7499 20.3625 42.3218 45.9751 43.9193 41.3909 21.8454 8.31637 27.7648
95.882 125.73 38.8704 46.574 110.9 32.3335 29.458 15.6694 22.3558 41.4085 43.4886 34.7937 44.8823 60.2097 45.1037 136.117 110.864 33.3056 117.749 138.528 73.1243 43.5009 143.239 96.3983 37.0552 83.8489 53.9825 112.515 48.0775 36.8526 51.0304 143.755 98.1658 69.0944 43.7249 38.014 68.4367 124.592 64.5893 36.2929 100.321 145.505 219.047 46.1022 24.6587 38.3643 109.879 17.0698 51.5651 69.6373 62.9348 91.1998 102.108 40.4629 33.4736 57.6745 61.2549 64.4421 66.33 34.3213 20.4313 47.4364
RI PT
61.789 71.485 27.281 25.4274 59.2853 18.3814 12.6749 12.8442 15.829 28.5405 29.0652 25.81 28.4256 42.0921 44.7793 83.3505 70.0436 21.5401 65.7758 81.7184 50.4745 28.569 79.9532 70.9821 20.0872 45.7972 35.6405 81.1257 32.1484 22.9679 32.7314 152.902 62.6094 45.468 27.6438 24.9138 50.8186 70.5259 47.8554 22.1019 50.3731 94.9248 131.656 27.0171 16.2599 26.7673 66.8451 14.2529 34.2415 42.3758 41.3313 68.9834 64.6661 29.2471 22.6481 36.0676 42.6237 38.7431 33.3561 25.9206 15.0726 34.5255
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
PHLA3_MOUSE Pleckstrin homology-like domain family A member 3 ABCD1_MOUSE ATP-binding cassette sub-family D member 1 HECD3_MOUSE E3 ubiquitin-protein ligase HECTD3 OCRL_MOUSE Inositol polyphosphate 5-phosphatase OCRL-1 PLPL2_MOUSE Patatin-like phospholipase domain-containing protein 2 BRX1_MOUSE Ribosome biogenesis protein BRX1 homolog CX7A2_MOUSE Cytochrome c oxidase subunit 7A2, mitochondrial DJC25_MOUSE DnaJ homolog subfamily C member 25 RRP1B_MOUSE Ribosomal RNA processing protein 1 homolog B FINC_MOUSE Fibronectin NIPBL_MOUSE Nipped-B-like protein DEN6A_MOUSE Protein DENND6A TBCEL_MOUSE Tubulin-specific chaperone cofactor E-like protein PWP2_MOUSE Periodic tryptophan protein 2 homolog EMC10_MOUSE ER membrane protein complex subunit 10 CD82_MOUSE CD82 antigen SRBP1_MOUSE Sterol regulatory element-binding protein 1 EPS8_MOUSE Epidermal growth factor receptor kinase substrate 8 GLMN_MOUSE Glomulin F2Z4A3_MOUSE Protein Fat1 GALT7_MOUSE N-acetylgalactosaminyltransferase 7 CLPT1_MOUSE Cleft lip and palate transmembrane protein 1 homolog EXOSX_MOUSE Exosome component 10 ATLA1_MOUSE Atlastin-1 RFNG_MOUSE Beta-1,3-N-acetylglucosaminyltransferase radical fringe CIR1A_MOUSE Cirhin MFTC_MOUSE Mitochondrial folate transporter/carrier TMM43_MOUSE Transmembrane protein 43 E9Q238_MOUSE Protein Kank1 TMUB2_MOUSE Transmembrane and ubiquitin-like domain-containing protein 2 SYPM_MOUSE Probable proline--tRNA ligase, mitochondrial PXMP2_MOUSE Peroxisomal membrane protein 2 E9Q7E2_MOUSE Protein Arid2 IREB2_MOUSE Iron-responsive element-binding protein 2 GRAM4_MOUSE GRAM domain-containing protein 4 EMC7_MOUSE ER membrane protein complex subunit 7 BST2_MOUSE Bone marrow stromal antigen 2 GBRAP_MOUSE Gamma-aminobutyric acid receptor-associated protein ASAH2_MOUSE Neutral ceramidase STPAP_MOUSE Speckle targeted PIP5K1A-regulated poly(A) polymerase BTG1_MOUSE Protein BTG1 SP2_MOUSE Transcription factor Sp2 NDUB4_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 AUP1_MOUSE Ancient ubiquitous protein 1 SGCB_MOUSE Beta-sarcoglycan APOE_MOUSE Apolipoprotein E DIP2B_MOUSE Disco-interacting protein 2 homolog B ARAP1_MOUSE Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 PLRG1_MOUSE Pleiotropic regulator 1 MTER1_MOUSE mTERF domain-containing protein 1, mitochondrial OSMR_MOUSE Oncostatin-M-specific receptor subunit beta ASPN_MOUSE Asporin NID2_MOUSE Nidogen-2 PBIP1_MOUSE Pre-B-cell leukemia transcription factor-interacting protein 1 BIG1_MOUSE Brefeldin A-inhibited guanine nucleotide-exchange protein 1 VPP2_MOUSE V-type proton ATPase 116 kDa subunit a isoform 2 A2AUP1_MOUSE Protein Pfkfb3 E9Q453_MOUSE Tropomyosin alpha-1 chain Q3U821_MOUSE Protein Wdr75 Q3TMP1_MOUSE General transcription factor IIIC, polypeptide 3 AQP1_MOUSE Aquaporin-1 R3GEF_MOUSE Guanine nucleotide exchange factor for Rab-3A
EP
Phlda3 Abcd1 Hectd3 Ocrl Pnpla2 Brix1 Cox7a2 Dnajc25 Rrp1b Fn1 Nipbl Dennd6a Tbcel Pwp2 Emc10 Cd82 Srebf1 Eps8 Glmn Fat1 Galnt7 Clptm1 Exosc10 Atl1 Rfng Cirh1a Slc25a32 Tmem43 Kank1 Tmub2 Pars2 Pxmp2 Arid2 Ireb2 Gramd4 Emc7 Bst2 Gabarap Asah2 Tut1 Btg1 Sp2 Ndufb4 Aup1 Sgcb Apoe Dip2b Arap1 Plrg1 Mterfd1 Osmr Aspn Nid2 Pbxip1 Arfgef1 Atp6v0a2 Pfkfb3 Tpm1 Wdr75 Gtf3c3 Aqp1 Rab3il1
AC C
sp|Q9WV95|PHLA3_MOUSE sp|P48410|ABCD1_MOUSE sp|Q3U487|HECD3_MOUSE sp|Q6NVF0|OCRL_MOUSE sp|Q8BJ56|PLPL2_MOUSE sp|Q9DCA5|BRX1_MOUSE sp|P48771|CX7A2_MOUSE sp|A2ALW5|DJC25_MOUSE sp|Q91YK2|RRP1B_MOUSE sp|P11276|FINC_MOUSE sp|Q6KCD5|NIPBL_MOUSE sp|Q8BH65|DEN6A_MOUSE sp|Q8C5W3|TBCEL_MOUSE sp|Q8BU03|PWP2_MOUSE sp|Q3TAS6|EMC10_MOUSE sp|P40237|CD82_MOUSE sp|Q9WTN3|SRBP1_MOUSE sp|Q08509|EPS8_MOUSE sp|Q8BZM1|GLMN_MOUSE tr|F2Z4A3|F2Z4A3_MOUSE sp|Q80VA0|GALT7_MOUSE sp|Q8VBZ3|CLPT1_MOUSE sp|P56960|EXOSX_MOUSE sp|Q8BH66|ATLA1_MOUSE sp|O09009|RFNG_MOUSE sp|Q8R2N2|CIR1A_MOUSE sp|Q8BMG8|MFTC_MOUSE sp|Q9DBS1|TMM43_MOUSE tr|E9Q238|E9Q238_MOUSE sp|Q3V209|TMUB2_MOUSE sp|Q8CFI5|SYPM_MOUSE sp|P42925|PXMP2_MOUSE tr|E9Q7E2|E9Q7E2_MOUSE sp|Q811J3|IREB2_MOUSE sp|Q8CB44|GRAM4_MOUSE sp|Q9EP72|EMC7_MOUSE sp|Q8R2Q8|BST2_MOUSE sp|Q9DCD6|GBRAP_MOUSE sp|Q9JHE3|ASAH2_MOUSE sp|Q8R3F9|STPAP_MOUSE sp|P62325|BTG1_MOUSE sp|Q9D2H6|SP2_MOUSE sp|Q9CQC7|NDUB4_MOUSE sp|P70295|AUP1_MOUSE sp|P82349|SGCB_MOUSE sp|P08226|APOE_MOUSE sp|Q3UH60|DIP2B_MOUSE sp|Q4LDD4|ARAP1_MOUSE sp|Q922V4|PLRG1_MOUSE sp|Q8R3J4|MTER1_MOUSE sp|O70458|OSMR_MOUSE sp|Q99MQ4|ASPN_MOUSE sp|O88322|NID2_MOUSE sp|Q3TVI8|PBIP1_MOUSE sp|G3X9K3|BIG1_MOUSE sp|P15920|VPP2_MOUSE tr|A2AUP1|A2AUP1_MOUSE tr|E9Q453|E9Q453_MOUSE tr|Q3U821|Q3U821_MOUSE tr|Q3TMP1|Q3TMP1_MOUSE sp|Q02013|AQP1_MOUSE sp|Q8VDV3|R3GEF_MOUSE
115.705 81.3579 40.5965 33.4457 65.8704 26.2929 21.1937 15.2344 20.0029 35.4848 39.3336 28.6263 41.1408 65.4379 78.3756 97.2762 58.1488 30.5933 58.8828 100.371 89.1359 29.7807 67.6877 85.4044 42.5653 64.9491 38.8193 116.7 50.0152 29.114 38.687 260.509 92.5226 79.8136 30.0107 28.4953 55.6418 43.3313 41.3236 23 47.383 99.201 243.114 28.7231 17.2341 31.1713 63.7378 12.0624 45.9654 42.2833 98.7245 92.6697 50.3559 34.7925 26.3497 51.1876 61.6384 50.1884 37.3142 31.9084 11.9964 38.8902
71.8767 509.171 27.6624 62.1167 41.2858 227.572 27.5775 21.5335 21.0448 19.4257 57.768 20.4346 40.6812 53.7733 28.0506 98.2699 25.002 54.7796 86.1082 79.0461 75.8217 15.6811 75.5498 53.4454 47.3676 51.6413 72.0093 114.724 43.0473 20.7321 19.6921 41.6802 105.422 114.485 39.4394 27.9239 37.3911 50.9929 22.5059 28.5949 63.1307 126.322 262.504 28.1669 17.9029 10.9246 87.3295 72.9205 44.6961 16.8361 54.3465 31.0777 47.3919 24.4397 32.4411 90.7763 46.2792 60.7604 40.6274 29.3844 107.757 24.8903
108.378 238.274 34.25 140.192 124.775 71.2186 17.1582 49.18 27.2716 27.5219 149.391 11.3076 69.8406 33.1148 24.5238 49.0457 3.45789 74.5775 38.5991 71.1122 47.8602 19.8737 50.9546 52.6983 51.2915 51.7157 48.956 91.3174 89.2566 8.73704 19.3186 75.7718 104.034 78.9068 60.024 16.5116 48.4495 41.4881 16.1442 40.9882 59.7197 89.3309 158.792 33.4017 0 19.3465 79.5916 31.9226 123.302 40.8051 76.6894 56.5231 36.8813 37.2971 22.071 42.7715 45.3392 106.564 30.1937 42.1305 55.632 27.8741
1.58 1.58 1.57 1.56 1.56 1.55 1.55 1.53 1.53 1.53 1.53 1.52 1.51 1.51 1.50 1.50 1.50 1.50 1.49 1.49 1.48 1.48 1.48 1.47 1.47 1.47 1.47 1.47 1.46 1.45 1.45 1.44 1.44 1.44 1.44 1.44 1.43 1.43 1.43 1.43 1.43 1.43 1.42 1.41 1.41 1.41 1.41 1.40 1.40 1.40 1.40 1.40 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39
1.35 5.72 1.22 3.94 1.46 7.90 1.37 3.51 1.75 0.93 3.82 0.76 1.94 1.04 0.64 0.95 0.25 3.04 1.05 0.94 1.13 0.72 0.89 0.86 1.83 1.02 1.91 1.32 1.97 0.65 0.63 0.42 1.59 1.87 1.94 0.96 0.99 0.79 0.52 1.68 1.19 1.26 1.30 1.16 0.60 0.61 1.35 5.05 2.41 0.72 1.13 0.67 0.77 1.14 1.27 1.70 1.03 2.02 0.95 1.50 6.99 0.85
ACCEPTED MANUSCRIPT
TE D
62.6884 41.4462 29.5109 78.9732 51.6882 30.5562 38.5691 33.5183 19.9427 74.4493 81.7059 36.0043 44.8574 47.6372 78.8928 17.9911 16.518 42.8252 12.561 17.4403 19.9874 64.6701 41.1283 17.2417 31.4557 55.3031 45.0012 47.6083 93.1727 21.8804 54.8067 66.4396 53.876 184.394 32.3967 39.8797 54.646 120.872 33.9997 41.8991 25.9143 48.6312 62.6096 16.7834 51.1531 78.9449 30.2285 31.7151 46.6111 31.0024 30.5442 78.3008 53.5675 45.9561 29.1294 71.6084 47.408 45.738 20.8164 43.409 78.3036 12.7442
99.3905 71.8609 27.3221 137.976 73.9055 41.2062 61.7313 48.6148 42.0533 95.3269 145.733 65.8741 77.0639 63.3374 133.856 40.0928 29.6622 48.0495 26.3821 23.3281 28.6602 96.8791 66.4266 20.4899 32.589 76.2494 59.9517 61.1255 136.763 34.9133 90.6244 107.088 121.205 333.659 47.5975 71.8058 94.709 206.473 44.5471 62.3178 38.6013 69.6978 85.476 28.7039 77.0154 84.7951 45.9131 34.5697 58.3845 42.9084 43.9105 59.2373 83.9552 64.0851 34.1643 99.6123 57.9458 63.1495 19.8484 66.021 120.614 19.2892
RI PT
54.9932 53.6831 20.9853 85.6937 49.2246 23.7078 45.5654 27.28 31.2349 60.3497 99.7443 48.0005 60.8148 44.6861 86.8866 25.9416 19.0309 22.7255 20.382 17.3959 20.5615 66.1889 46.5824 17.9184 17.3294 53.8116 44.6466 38.9324 89.0959 20.2358 53.4917 78.2165 89.7302 204.388 34.0587 45.7467 59.2878 151.586 34.661 42.0802 30.2297 51.2809 60.607 20.5007 63.7861 64.8837 27.2513 21.521 45.9724 28.358 35.3769 43.678 67.9637 42.7971 27.3698 65.6123 45.9977 45.3611 15.8915 44.9211 64.7169 14.3318
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
PT117_MOUSE Protein PET117 homolog, mitochondrial PYRG1_MOUSE CTP synthase 1 CBX4_MOUSE E3 SUMO-protein ligase CBX4 SEC20_MOUSE Vesicle transport protein SEC20 ZCCHV_MOUSE Zinc finger CCCH-type antiviral protein 1 IMP1L_MOUSE Mitochondrial inner membrane protease subunit 1 NSUN6_MOUSE Putative methyltransferase NSUN6 COX16_MOUSE Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial BRD9_MOUSE Bromodomain-containing protein 9 JCAD_MOUSE Junctional protein associated with coronary artery disease EPG5_MOUSE Ectopic P granules protein 5 homolog MOR2A_MOUSE MORC family CW-type zinc finger protein 2A TM205_MOUSE Transmembrane protein 205 MKRN2_MOUSE Probable E3 ubiquitin-protein ligase makorin-2 DUS3L_MOUSE tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like UVSSA_MOUSE UV-stimulated scaffold protein A DOP1_MOUSE Protein dopey-1 TOM34_MOUSE Mitochondrial import receptor subunit TOM34 GLYC_MOUSE Serine hydroxymethyltransferase, cytosolic PKHG3_MOUSE Pleckstrin homology domain-containing family G member 3 CD44_MOUSE CD44 antigen RBPMS_MOUSE RNA-binding protein with multiple splicing ALG12_MOUSE Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase TMED1_MOUSE Transmembrane emp24 domain-containing protein 1 PKHA6_MOUSE Pleckstrin homology domain-containing family A member 6 NVL_MOUSE Nuclear valosin-containing protein-like RM23_MOUSE 39S ribosomal protein L23, mitochondrial A4_MOUSE Amyloid beta A4 protein SOS1_MOUSE Son of sevenless homolog 1 RIN2_MOUSE Ras and Rab interactor 2 TBC31_MOUSE TBC1 domain family member 31 WLS_MOUSE Protein wntless homolog PI42A_MOUSE Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha NMNA1_MOUSE Nicotinamide mononucleotide adenylyltransferase 1 NPA1P_MOUSE Nucleolar pre-ribosomal-associated protein 1 C560_MOUSE Succinate dehydrogenase cytochrome b560 subunit, mitochondrial CTL2_MOUSE Choline transporter-like protein 2 SLIT3_MOUSE Slit homolog 3 protein METL9_MOUSE Methyltransferase-like protein 9 CMKMT_MOUSE Calmodulin-lysine N-methyltransferase B1ART1_MOUSE Protein Vps13d TBL3_MOUSE Transducin beta-like protein 3 SPD2B_MOUSE SH3 and PX domain-containing protein 2B E9PVS5_MOUSE Mitochondrial inner membrane protein (Fragment) E0CXD7_MOUSE LIM domain only protein 3 UTP6_MOUSE U3 small nucleolar RNA-associated protein 6 homolog MFAP3_MOUSE Microfibril-associated glycoprotein 3 NSMA3_MOUSE Sphingomyelin phosphodiesterase 4 RFA1_MOUSE Replication protein A 70 kDa DNA-binding subunit ZFY16_MOUSE Zinc finger FYVE domain-containing protein 16 NUDT6_MOUSE Nucleoside diphosphate-linked moiety X motif 6 TBCC_MOUSE Tubulin-specific chaperone C IL6RB_MOUSE Interleukin-6 receptor subunit beta CASP7_MOUSE Caspase-7 KC1D_MOUSE Casein kinase I isoform delta HPS5_MOUSE Hermansky-Pudlak syndrome 5 protein homolog Q7TNL7_MOUSE Dual specificity protein phosphatase MYO19_MOUSE Unconventional myosin-XIX OTUL_MOUSE Ubiquitin thioesterase otulin MCE1_MOUSE mRNA-capping enzyme ALKB3_MOUSE Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 CCNK_MOUSE Cyclin-K
EP
Pet117 Ctps1 Cbx4 Bnip1 Zc3hav1 Immp1l Nsun6 Cox16 Brd9 Jcad Epg5 Morc2a Tmem205 Mkrn2 Dus3l Uvssa Dopey1 Tomm34 Shmt1 Plekhg3 Cd44 Rbpms Alg12 Tmed1 Plekha6 Nvl Mrpl23 App Sos1 Rin2 Tbc1d31 Wls Pip4k2a Nmnat1 Urb1 Sdhc Slc44a2 Slit3 Mettl9 Camkmt Vps13d Tbl3 Sh3pxd2b Immt Lmo3 Utp6 Mfap3 Smpd4 Rpa1 Zfyve16 Nudt6 Tbcc Il6st Casp7 Csnk1d Hps5 Dusp9 Myo19 Otulin Rngtt Alkbh3 Ccnk
AC C
sp|P0DJF2|PT117_MOUSE sp|P70698|PYRG1_MOUSE sp|O55187|CBX4_MOUSE sp|Q6QD59|SEC20_MOUSE sp|Q3UPF5|ZCCHV_MOUSE sp|Q9CQU8|IMP1L_MOUSE sp|Q7TS68|NSUN6_MOUSE sp|Q9CR63|COX16_MOUSE sp|Q3UQU0|BRD9_MOUSE sp|Q5DTX6|JCAD_MOUSE sp|Q80TA9|EPG5_MOUSE sp|Q69ZX6|MOR2A_MOUSE sp|Q91XE8|TM205_MOUSE sp|Q9ERV1|MKRN2_MOUSE sp|Q91XI1|DUS3L_MOUSE sp|Q9D479|UVSSA_MOUSE sp|Q8BL99|DOP1_MOUSE sp|Q9CYG7|TOM34_MOUSE sp|P50431|GLYC_MOUSE sp|Q4VAC9|PKHG3_MOUSE sp|P15379|CD44_MOUSE sp|Q9WVB0|RBPMS_MOUSE sp|Q8VDB2|ALG12_MOUSE sp|Q3V009|TMED1_MOUSE sp|Q7TQG1|PKHA6_MOUSE sp|Q9DBY8|NVL_MOUSE sp|O35972|RM23_MOUSE sp|P12023|A4_MOUSE sp|Q62245|SOS1_MOUSE sp|Q9D684|RIN2_MOUSE sp|Q6NXY1|TBC31_MOUSE sp|Q6DID7|WLS_MOUSE sp|O70172|PI42A_MOUSE sp|Q9EPA7|NMNA1_MOUSE sp|Q571H0|NPA1P_MOUSE sp|Q9CZB0|C560_MOUSE sp|Q8BY89|CTL2_MOUSE sp|Q9WVB4|SLIT3_MOUSE sp|Q9EPL4|METL9_MOUSE sp|Q3U2J5|CMKMT_MOUSE tr|B1ART1|B1ART1_MOUSE sp|Q8C4J7|TBL3_MOUSE sp|A2AAY5|SPD2B_MOUSE tr|E9PVS5|E9PVS5_MOUSE tr|E0CXD7|E0CXD7_MOUSE sp|Q8VCY6|UTP6_MOUSE sp|Q922T2|MFAP3_MOUSE sp|Q6ZPR5|NSMA3_MOUSE sp|Q8VEE4|RFA1_MOUSE sp|Q80U44|ZFY16_MOUSE sp|Q8CH40|NUDT6_MOUSE sp|Q8VCN9|TBCC_MOUSE sp|Q00560|IL6RB_MOUSE sp|P97864|CASP7_MOUSE sp|Q9DC28|KC1D_MOUSE sp|P59438|HPS5_MOUSE tr|Q7TNL7|Q7TNL7_MOUSE sp|Q5SV80|MYO19_MOUSE sp|Q3UCV8|OTUL_MOUSE sp|O55236|MCE1_MOUSE sp|Q8K1E6|ALKB3_MOUSE sp|O88874|CCNK_MOUSE
63.4414 59.4885 42.0735 88.2919 64.7424 33.2987 53.6048 34.668 27.7452 88.4837 101.559 48.4903 66.7272 62.2145 91.441 19.505 18.5444 40.5184 18.0627 23.6662 26.001 78.9892 51.4444 26.753 32.9496 70.1725 60.3304 54.9086 107.6 21.5462 54.0879 86.0865 70.4391 184.466 40.897 42.1919 56.8911 155.862 46.4415 48.9391 35.7536 62.2822 77.2266 20.5257 74.5012 104.58 29.6443 35.2874 63.0059 34.9144 42.4872 100.11 74.372 51.5129 39.386 78.8681 63.4418 55.0816 27.7711 48.5266 64.0264 15.6648
80.8075 64.0357 40.3503 110.175 80.5899 32.2079 73.6209 76.9692 80.057 78.1981 44.0652 46.1238 41.5821 27.3016 64.8198 20.649 22.078 74.495 24.5064 29.3867 39.2905 69.9923 61.4872 16.1108 17.5699 146.405 20.2349 56.0129 121.362 27.88 47.5557 88.1802 66.7684 114.794 87.6902 93.0964 90.0583 147.938 42.0256 57.7288 41.0608 77.2082 75.5968 34.8844 53.2858 83.7882 16.07 42.3968 78.533 39.252 6.62595 116.915 62.6542 68.3451 16.6765 68.1512 88.1082 67.7606 25.0232 76.1233 47.4429 24.0793
88.0532 51.0856 74.469 109.791 115.343 33.7578 177.898 117.18 70.8485 170.826 62.6812 94.6167 40.2934 83.0752 108.925 19.6374 20.9138 59.2605 6.40095 71.4762 37.6438 161.051 48.9042 9.9645 53.6665 155.35 48.1389 90.6179 84.8851 32.4289 157.901 64.8076 55.4991 192.871 58.3794 158.635 35.1146 111.971 28.6308 30.3745 33.4894 44.4715 68.9982 24.9328 77.3296 28.7508 18.5534 28.0525 57.2073 42.3271 14.1394 161.898 64.3745 94.5652 24.0419 83.7043 97.8373 71.2119 19.769 111.334 115.053 15.506
1.38 1.38 1.37 1.37 1.37 1.37 1.37 1.37 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.35 1.35 1.35 1.35 1.34 1.34 1.34 1.34 1.34 1.34 1.34 1.34 1.34 1.34 1.34 1.33 1.33 1.33 1.33 1.33 1.33 1.33 1.32 1.32 1.32 1.32 1.32 1.32 1.32 1.31 1.31 1.31 1.31 1.31 1.31 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.29 1.29
1.43 1.21 2.27 1.34 1.94 1.22 2.99 3.19 2.95 1.85 0.59 1.68 0.77 1.20 1.05 0.92 1.21 2.04 0.94 2.90 1.90 1.77 1.26 0.74 1.46 2.77 0.76 1.69 1.13 1.43 1.90 1.06 0.85 0.79 2.20 2.94 1.10 0.95 1.03 1.05 1.33 1.22 1.17 1.60 1.14 0.78 0.60 1.32 1.47 1.37 0.32 2.29 1.05 1.84 0.72 1.11 1.99 1.53 1.22 2.12 1.14 1.46
ACCEPTED MANUSCRIPT
22.3647 82.6705 23.7128 36.1303 64.2988 41.3306 119.272 45.441 48.1217 68.5997 23.2861 39.79 238.97 21.5632 60.3258 60.0526 92.8762 50.346 153.098 36.7495 35.3375 40.2524 62.6897 24.1866 36.788 33.2211 54.8027 50.8117 16.6965 62.0099 38.5446 18.2095 73.1059 43.2757 78.1162 32.4643 13.6306 19.5176 48.7595 44.3712 66.3807 23.2843 16.4033 76.8232 35.2154 26.1193 64.5016 48.1357 81.5006 46.3468 33.9604 38.486 38.9763 35.8748 28.1733 22.4296 33.2555 46.0815 46.1631 106.648 17.972 50.4753
45.0955 80.9298 35.8949 53.3326 64.9862 45.5728 89.1517 56.9922 80.9949 82.2745 33.3193 64.7651 299.916 22.7054 47.6463 91.8063 134.729 68.1227 201.506 54.2156 64.9025 67.85 111.264 40.2973 50.6189 40.3424 72.0196 81.4691 23.1546 93.0019 64.5881 21.0291 102.835 36.2111 101.419 76.4396 15.3543 29.6553 50.9948 64.7123 38.7564 35.949 26.4714 87.3509 46.5419 31.5021 99.4129 74.4527 102.871 77.311 44.3302 44.8195 52.1727 62.3558 37.4366 22.1407 45.9637 69.2935 60.898 146.57 28.6079 69.8111
RI PT
31.1488 51.5546 25.2496 37.4752 37.6456 37.813 77.7389 38.4819 60.6425 52.5766 24.3306 48.1056 231.917 16.7255 30.9429 74.8758 94.567 55.9074 145.305 36.818 47.3175 45.4701 84.7243 38.4018 35.0213 27.0427 49.4864 60.4777 12.4438 74.5732 48.5916 17.0109 76.4927 24.5994 78.3563 61.6942 11.8932 25.2352 39.2456 47.2898 39.3962 29.8042 19.9744 63.7708 34.5802 24.9476 70.7902 46.8717 72.1444 61.6676 30.1254 37.1728 37.0134 45.817 23.8879 19.2988 30.9534 55.5262 44.9519 110.466 26.9893 50.2909
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
TE D
Nol6 Jak1 Smg6 Polr2b Epdr1 Hat1 Micall2 Arhgef1 Man1a2 Mvk Cyth1 Tmem57 Zcchc6 Arih2 Fbxo22 Stk25 Mrps11 Zcrb1 Gtf2h1 Ndc1 Mrpl13 Slc35b3 Itfg3 Mb Dhx57 Tnfrsf1a Pnpla7 Kdm5c Gsk3a Tpm2 Htt Tmem199 Thoc7 Fam173b Nrbp2 Morf4l2 Sirt2 Abl1 Map4k5 Narfl Oxt Mob2 Bmi1 Fam65a Map4k3 Tmppe Nelfcd Rab6b Dimt1 Sptan1 Mtmr6 Cers4 Phf2 Sumo1
UBP30_MOUSE Ubiquitin carboxyl-terminal hydrolase 30 ABHDB_MOUSE Alpha/beta hydrolase domain-containing protein 11 PA2G5_MOUSE Calcium-dependent phospholipase A2 ADCK5_MOUSE Uncharacterized aarF domain-containing protein kinase 5 PLCH2_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 ELOV1_MOUSE Elongation of very long chain fatty acids protein 1 FHL3_MOUSE Four and a half LIM domains protein 3 CA198_MOUSE Uncharacterized protein C1orf198 homolog NOL6_MOUSE Nucleolar protein 6 JAK1_MOUSE Tyrosine-protein kinase JAK1 EST1A_MOUSE Telomerase-binding protein EST1A RPB2_MOUSE DNA-directed RNA polymerase II subunit RPB2 EPDR1_MOUSE Mammalian ependymin-related protein 1 HAT1_MOUSE Histone acetyltransferase type B catalytic subunit MILK2_MOUSE MICAL-like protein 2 ARHG1_MOUSE Rho guanine nucleotide exchange factor 1 MA1A2_MOUSE Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB KIME_MOUSE Mevalonate kinase CYH1_MOUSE Cytohesin-1 MACOI_MOUSE Macoilin TUT7_MOUSE Terminal uridylyltransferase 7 ARI2_MOUSE E3 ubiquitin-protein ligase ARIH2 FBX22_MOUSE F-box only protein 22 STK25_MOUSE Serine/threonine-protein kinase 25 RT11_MOUSE 28S ribosomal protein S11, mitochondrial ZCRB1_MOUSE Zinc finger CCHC-type and RNA-binding motif-containing protein 1 TF2H1_MOUSE General transcription factor IIH subunit 1 NDC1_MOUSE Nucleoporin NDC1 RM13_MOUSE 39S ribosomal protein L13, mitochondrial S35B3_MOUSE Adenosine 3'-phospho 5'-phosphosulfate transporter 2 ITFG3_MOUSE Protein ITFG3 MYG_MOUSE Myoglobin DHX57_MOUSE Putative ATP-dependent RNA helicase DHX57 TNR1A_MOUSE Tumor necrosis factor receptor superfamily member 1A PLPL7_MOUSE Patatin-like phospholipase domain-containing protein 7 KDM5C_MOUSE Lysine-specific demethylase 5C GSK3A_MOUSE Glycogen synthase kinase-3 alpha TPM2_MOUSE Isoform 2 of Tropomyosin beta chain HD_MOUSE Huntingtin TM199_MOUSE Transmembrane protein 199 THOC7_MOUSE THO complex subunit 7 homolog F173B_MOUSE Protein FAM173B NRBP2_MOUSE Nuclear receptor-binding protein 2 MO4L2_MOUSE Mortality factor 4-like protein 2 SIR2_MOUSE NAD-dependent protein deacetylase sirtuin-2 ABL1_MOUSE Tyrosine-protein kinase ABL1 M4K5_MOUSE Mitogen-activated protein kinase kinase kinase kinase 5 NARFL_MOUSE Cytosolic Fe-S cluster assembly factor NARFL NEU1_MOUSE Oxytocin-neurophysin 1 MOB2_MOUSE MOB kinase activator 2 BMI1_MOUSE Polycomb complex protein BMI-1 FA65A_MOUSE Protein FAM65A M4K3_MOUSE Mitogen-activated protein kinase kinase kinase kinase 3 D3Z286_MOUSE Protein Tmppe NELFD_MOUSE Negative elongation factor D RAB6B_MOUSE Ras-related protein Rab-6B DIM1_MOUSE Probable dimethyladenosine transferase SPTN1_MOUSE Isoform 2 of Spectrin alpha chain, non-erythrocytic 1 MTMR6_MOUSE Myotubularin-related protein 6 CERS4_MOUSE Ceramide synthase 4 PHF2_MOUSE Lysine-specific demethylase PHF2 SUMO1_MOUSE Small ubiquitin-related modifier 1
EP
Usp30 Abhd11 Pla2g5 Adck5 Plch2 Elovl1 Fhl3
AC C
sp|Q3UN04|UBP30_MOUSE sp|Q8K4F5|ABHDB_MOUSE sp|P97391|PA2G5_MOUSE sp|Q80V03|ADCK5_MOUSE sp|A2AP18|PLCH2_MOUSE sp|Q9JLJ5|ELOV1_MOUSE sp|Q9R059|FHL3_MOUSE sp|Q8C3W1|CA198_MOUSE sp|Q8R5K4|NOL6_MOUSE sp|P52332|JAK1_MOUSE sp|P61406|EST1A_MOUSE sp|Q8CFI7|RPB2_MOUSE sp|Q99M71|EPDR1_MOUSE sp|Q8BY71|HAT1_MOUSE sp|Q3TN34|MILK2_MOUSE sp|Q61210|ARHG1_MOUSE sp|P39098|MA1A2_MOUSE sp|Q9R008|KIME_MOUSE sp|Q9QX11|CYH1_MOUSE sp|Q7TQE6|MACOI_MOUSE sp|Q5BLK4|TUT7_MOUSE sp|Q9Z1K6|ARI2_MOUSE sp|Q78JE5|FBX22_MOUSE sp|Q9Z2W1|STK25_MOUSE sp|Q9DCA2|RT11_MOUSE sp|Q9CZ96|ZCRB1_MOUSE sp|Q9DBA9|TF2H1_MOUSE sp|Q8VCB1|NDC1_MOUSE sp|Q9D1P0|RM13_MOUSE sp|Q922Q5|S35B3_MOUSE sp|Q8C0Z1|ITFG3_MOUSE sp|P04247|MYG_MOUSE sp|Q6P5D3|DHX57_MOUSE sp|P25118|TNR1A_MOUSE sp|A2AJ88|PLPL7_MOUSE sp|P41230|KDM5C_MOUSE sp|Q2NL51|GSK3A_MOUSE sp|P58774-2|TPM2_MOUSE sp|P42859|HD_MOUSE sp|Q5SYH2|TM199_MOUSE sp|Q7TMY4|THOC7_MOUSE sp|Q9D1Z3|F173B_MOUSE sp|Q91V36|NRBP2_MOUSE sp|Q9R0Q4|MO4L2_MOUSE sp|Q8VDQ8|SIR2_MOUSE sp|P00520|ABL1_MOUSE sp|Q8BPM2|M4K5_MOUSE sp|Q7TMW6|NARFL_MOUSE sp|P35454|NEU1_MOUSE sp|Q8VI63|MOB2_MOUSE sp|P25916|BMI1_MOUSE sp|Q68FE6|FA65A_MOUSE sp|Q99JP0|M4K3_MOUSE tr|D3Z286|D3Z286_MOUSE sp|Q922L6|NELFD_MOUSE sp|P61294|RAB6B_MOUSE sp|Q9D0D4|DIM1_MOUSE sp|P16546-2|SPTN1_MOUSE sp|Q8VE11|MTMR6_MOUSE sp|Q9D6J1|CERS4_MOUSE sp|Q9WTU0|PHF2_MOUSE sp|P63166|SUMO1_MOUSE
23.9834 92.2151 27.2131 41.515 66.3755 56.1595 163.893 50.7425 58.5215 73.121 27.6233 47.7127 301.948 26.2325 68.9876 80.5346 104.496 67.3531 178.642 39.4988 40.3671 41.215 76.284 39.2733 40.6658 36.2043 60.28 59.5642 13.7502 79.8093 45.6409 23.52 86.3475 49.5821 96.0261 42.3567 16.8396 26.711 59.7738 50.5843 94.1267 30.6841 19.1858 89.0872 41.0318 32.4972 70.1317 44.6076 88.9792 57.4899 35.6466 49.5972 42.572 39.4847 27.4607 29.8584 34.0393 57.297 52.4999 123.526 27.2509 55.0122
40.7166 63.5491 0 75.0302 14.2283 37.641 27.9611 24.1826 55.2355 78.4052 21.4274 46.4608 123.616 29.5686 95.9178 81.287 76.4091 33.9057 118.887 31.1273 48.5508 61.8242 115.357 23.9936 19.442 24.6975 64.2004 79.0777 10.3324 20.2546 28.8776 94.0483 101.471 22.415 72.7287 43.07 24.9145 26.6892 75.6071 54.5492 48.4762 26.2913 34.9639 33.3357 44.9661 36.6184 80.4133 44.3252 70.7277 38.185 37.1885 35.034 41.6932 62.1335 36.8356 32.5455 60.0324 63.7705 57.1624 98.4375 37.0005 67.4173
24.9995 101.418 0.0534311 71.1607 75.8931 26.6458 36.1901 43.7673 67.0576 99.4637 49.1498 31.9484 163.516 20.8627 208.915 94.869 71.031 32.9656 139.738 58.0051 39.5432 56.3331 61.074 16.9497 32.7427 40.6103 67.1271 53.7859 19.6953 41.7812 16.8215 121.945 58.4716 61.16 67.3457 60.1059 41.4124 36.501 47.6653 48.3768 61.0259 52.6097 20.9012 27.0186 53.873 61.2794 66.0454 55.4985 86.5962 34.2968 53.4983 55.2739 45.9757 24.9456 30.8381 29.949 40.7488 71.8195 41.5091 117.631 49.5916 134.54
1.29 1.29 1.29 1.29 1.29 1.29 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.24 1.24 1.24 1.24
1.23 1.23 0.00 1.99 0.88 0.81 0.33 0.81 1.12 1.47 1.48 0.89 0.61 1.32 3.34 1.31 0.79 0.63 0.87 1.21 1.07 1.38 1.20 0.65 0.73 1.08 1.26 1.19 1.03 0.45 0.52 6.13 1.07 1.23 0.90 1.10 2.60 1.41 1.40 1.12 1.04 1.49 1.54 0.43 1.42 1.92 1.08 1.05 1.02 0.67 1.42 1.19 1.15 1.07 1.30 1.50 1.57 1.33 1.08 1.00 1.93 2.00
ACCEPTED MANUSCRIPT
46.2067 29.0395 20.2569 41.3268 94.0479 23.369 39.8278 135.354 68.143 20.604 32.3203 16.4022 50.9423 60.0608 44.6185 66.8646 31.632 53.5065 56.0271 93.4819 16.1681 59.0585 37.8405 64.0797 28.3583 105.406 63.7551 56.4524 48.4451 10.6396 76.4083 14.5718 41.7245 53.5678 29.0968 29.744 29.7747 46.9607 17.2825 23.1549 25.7048 27.5003 49.1669 32.5635 86.7899 29.7759 62.4414 54.2396 43.2704 55.9879 43.5909 24.8006 77.5551 67.64 103.047 48.9314 50.033 43.8624 71.0353 23.1998 47.6695 22.3402
61.4759 26.9683 24.8576 56.9347 120.18 32.6159 57.1452 207.583 104.812 32.7985 50.2686 30.0198 72.8825 93.6637 60.654 106.402 42.4628 66.2898 93.9069 121.16 19.437 43.6394 47.3888 69.0282 48.8822 92.2443 74.6257 85.2407 78.1619 17.8116 104.468 33.5286 54.4705 75.0721 39.4387 38.2881 48.3194 60.5015 28.1962 24.1955 39.0793 34.2977 74.8804 38.3093 106.104 42.308 71.8039 82.3577 65.9871 88.9442 32.1093 36.6494 92.19 85.2201 196.09 85.6222 70.9571 36.9255 90.2408 32.104 52.1144 30.5815
RI PT
47.938 20.7393 18.6501 52.7665 101.797 24.2095 46.6463 149.984 81.6161 21.3649 42.1075 20.0727 51.2021 66.9537 45.6946 81.6042 31.814 52.509 76.6398 92.5203 15.8837 34.1694 43.0582 60.3746 47.2251 85.6958 51.4695 58.4802 71.755 13.6776 73.0224 30.822 42.3887 53.8747 30.119 27.9516 44.2242 43.1645 25.0516 16.5656 26.9697 28.2829 49.7883 24.409 83.3609 36.4458 50.1617 60.8154 52.0933 70.5343 20.5021 31.2803 82.3566 69.4529 132.656 60.7703 54.7742 45.5793 71.3216 25.8579 31.2488 27.1131
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
TE D
INT6_MOUSE Integrator complex subunit 6 CTR1_MOUSE High affinity cationic amino acid transporter 1 PDE9A_MOUSE High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A DICER_MOUSE Endoribonuclease Dicer RGS1_MOUSE Regulator of G-protein signaling 1 RPTOR_MOUSE Regulatory-associated protein of mTOR NOL8_MOUSE Nucleolar protein 8 GLCI1_MOUSE Glucocorticoid-induced transcript 1 protein S35B2_MOUSE Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Q80X68_MOUSE Citrate synthase CCNH_MOUSE Cyclin-H ALS2_MOUSE Alsin STEA3_MOUSE Metalloreductase STEAP3 SOAT1_MOUSE Sterol O-acyltransferase 1 CD2B2_MOUSE CD2 antigen cytoplasmic tail-binding protein 2 MPP8_MOUSE M-phase phosphoprotein 8 WASF1_MOUSE Wiskott-Aldrich syndrome protein family member 1 IQCB1_MOUSE IQ calmodulin-binding motif-containing protein 1 SCAM1_MOUSE Secretory carrier-associated membrane protein 1 TNAP2_MOUSE Tumor necrosis factor alpha-induced protein 2 DPOLZ_MOUSE DNA polymerase zeta catalytic subunit MPRD_MOUSE Cation-dependent mannose-6-phosphate receptor NUDT7_MOUSE Peroxisomal coenzyme A diphosphatase NUDT7 CEBPZ_MOUSE CCAAT/enhancer-binding protein zeta SHPK_MOUSE Sedoheptulokinase NOM1_MOUSE Nucleolar MIF4G domain-containing protein 1 TANC1_MOUSE Protein TANC1 CERS5_MOUSE Ceramide synthase 5 REEP4_MOUSE Receptor expression-enhancing protein 4 NXT1_MOUSE NTF2-related export protein 1 CSK_MOUSE Tyrosine-protein kinase CSK ELYS_MOUSE Protein ELYS EP400_MOUSE E1A-binding protein p400 SPTCS_MOUSE Spatacsin SAS10_MOUSE Something about silencing protein 10 RENR_MOUSE Renin receptor YES_MOUSE Tyrosine-protein kinase Yes BORG5_MOUSE Cdc42 effector protein 1 TSN31_MOUSE Tetraspanin-31 E9QAH1_MOUSE Protein Golgb1 BCAS3_MOUSE Breast carcinoma-amplified sequence 3 homolog MET18_MOUSE Histidine protein methyltransferase 1 homolog TERF2_MOUSE Telomeric repeat-binding factor 2 CF047_MOUSE Uncharacterized protein C6orf47 homolog RM55_MOUSE 39S ribosomal protein L55, mitochondrial RBMX_MOUSE RNA-binding motif protein, X chromosome C102A_MOUSE Coiled-coil domain-containing protein 102A AP1G2_MOUSE AP-1 complex subunit gamma-like 2 ATP7A_MOUSE Copper-transporting ATPase 1 COX20_MOUSE Cytochrome c oxidase protein 20 homolog IMA1_MOUSE Importin subunit alpha-1 VAMP7_MOUSE Vesicle-associated membrane protein 7 LRP6_MOUSE Low-density lipoprotein receptor-related protein 6 EPMIP_MOUSE EPM2A-interacting protein 1 ECT2_MOUSE Protein ECT2 DHR11_MOUSE Dehydrogenase/reductase SDR family member 11 ARI1_MOUSE E3 ubiquitin-protein ligase ARIH1 Q8BH78_MOUSE Reticulon ABHEB_MOUSE Alpha/beta hydrolase domain-containing protein 14B RB22A_MOUSE Ras-related protein Rab-22A KMT2A_MOUSE Histone-lysine N-methyltransferase 2A MED1_MOUSE Mediator of RNA polymerase II transcription subunit 1
EP
Ints6 Slc7a1 Pde9a Dicer1 Rgs1 Rptor Nol8 Glcci1 Slc35b2 Csl Ccnh Als2 Steap3 Soat1 Cd2bp2 Mphosph8 Wasf1 Iqcb1 Scamp1 Tnfaip2 Rev3l M6pr Nudt7 Cebpz Shpk Nom1 Tanc1 Cers5 Reep4 Nxt1 Csk Ahctf1 Ep400 Spg11 Utp3 Atp6ap2 Yes1 Cdc42ep1 Tspan31 Golgb1 Bcas3 Mettl18 Terf2 D17h6s53e Mrpl55 Rbmx Ccdc102a Ap1g2 Atp7a Cox20 Kpna2 Vamp7 Lrp6 Epm2aip1 Ect2 Dhrs11 Arih1 Rtn4 Abhd14b Rab22a Kmt2a Med1
AC C
sp|Q6PCM2|INT6_MOUSE sp|Q09143|CTR1_MOUSE sp|O70628|PDE9A_MOUSE sp|Q8R418|DICER_MOUSE sp|Q9JL25|RGS1_MOUSE sp|Q8K4Q0|RPTOR_MOUSE sp|Q3UHX0|NOL8_MOUSE sp|Q8K3I9|GLCI1_MOUSE sp|Q91ZN5|S35B2_MOUSE tr|Q80X68|Q80X68_MOUSE sp|Q61458|CCNH_MOUSE sp|Q920R0|ALS2_MOUSE sp|Q8CI59|STEA3_MOUSE sp|Q61263|SOAT1_MOUSE sp|Q9CWK3|CD2B2_MOUSE sp|Q3TYA6|MPP8_MOUSE sp|Q8R5H6|WASF1_MOUSE sp|Q8BP00|IQCB1_MOUSE sp|Q8K021|SCAM1_MOUSE sp|Q61333|TNAP2_MOUSE sp|Q61493|DPOLZ_MOUSE sp|P24668|MPRD_MOUSE sp|Q99P30|NUDT7_MOUSE sp|P53569|CEBPZ_MOUSE sp|Q9D5J6|SHPK_MOUSE sp|Q3UFM5|NOM1_MOUSE sp|Q0VGY8|TANC1_MOUSE sp|Q9D6K9|CERS5_MOUSE sp|Q8K072|REEP4_MOUSE sp|Q9QZV9|NXT1_MOUSE sp|P41241|CSK_MOUSE sp|Q8CJF7|ELYS_MOUSE sp|Q8CHI8|EP400_MOUSE sp|Q3UHA3|SPTCS_MOUSE sp|Q9JI13|SAS10_MOUSE sp|Q9CYN9|RENR_MOUSE sp|Q04736|YES_MOUSE sp|Q91W92|BORG5_MOUSE sp|Q9CQ88|TSN31_MOUSE tr|E9QAH1|E9QAH1_MOUSE sp|Q8CCN5|BCAS3_MOUSE sp|Q9CZ09|MET18_MOUSE sp|O35144|TERF2_MOUSE sp|Q9Z1R4|CF047_MOUSE sp|Q9CZ83|RM55_MOUSE sp|Q9WV02|RBMX_MOUSE sp|Q3TMW1|C102A_MOUSE sp|O88512|AP1G2_MOUSE sp|Q64430|ATP7A_MOUSE sp|Q9D7J4|COX20_MOUSE sp|P52293|IMA1_MOUSE sp|P70280|VAMP7_MOUSE sp|O88572|LRP6_MOUSE sp|Q8VEH5|EPMIP_MOUSE sp|Q07139|ECT2_MOUSE sp|Q3U0B3|DHR11_MOUSE sp|Q9Z1K5|ARI1_MOUSE tr|Q8BH78|Q8BH78_MOUSE sp|Q8VCR7|ABHEB_MOUSE sp|P35285|RB22A_MOUSE sp|P55200|KMT2A_MOUSE sp|Q925J9|MED1_MOUSE
55.0854 34.6565 23.2935 59.1314 121.398 25.9581 49.2929 142.901 78.9709 18.6786 40.9901 14.6741 52.1227 61.68 49.7873 75.0567 35.0477 63.2174 68.0736 105.859 19.6789 70.0601 51.2204 82.6652 43.2206 140.585 65.7083 54.656 68.1105 11.7517 77.0269 21.518 47.522 55.1815 32.3132 31.6211 41.3273 48.5799 23.0084 23.8465 24.5248 32.7125 43.9846 30.1196 98.1752 37.0379 63.0058 55.3139 48.0466 62.2646 44.4333 30.297 98.6862 78.175 84.7278 45.0646 53.8107 69.3388 78.7722 26.0381 41.2609 27.9213
67.6548 85.9097 14.9879 31.9618 1.04265 43.8137 92.7197 55.8652 85.6746 17.0438 29.7745 21.5212 47.0559 164.438 64.7593 48.523 28.2649 59.9931 57.1542 106.743 26.4119 173.423 24.4844 100.049 19.2782 121.425 42.4766 57.97 88.6072 180.404 95.2595 143.806 64.2067 81.8646 34.8549 30.7774 41.7948 12.7029 27.8121 25.3946 44.8667 34.8958 47.4762 14.662 25.7149 23.4058 24.8677 46.0033 75.1343 53.5706 23.2446 39.4956 52.525 48.5141 113.86 41.8272 42.0555 33.92 26.7488 35.0617 26.3593 22.4576
38.7735 29.0005 18.5253 50.1299 9.8572 30.9565 53.8944 99.6231 60.7806 14.7235 21.8499 42.9904 39.2254 102.031 153.994 65.2547 51.2018 22.7012 45.5453 81.0582 23.7364 68.8533 40.7749 45.2902 27.419 111.898 35.7103 44.3752 54.7342 252.662 64.3501 121.385 80.2334 56.3806 18.2127 34.1725 61.7163 16.9313 20.3501 56.2204 54.4042 28.1943 31.1536 22.4617 92.3345 44.7129 56.5926 35.5366 45.9673 80.1684 44.2968 28.4218 76.7961 66.199 186.226 85.6281 59.4782 27.1988 66.5211 26.611 37.1052 41.3856
1.24 1.24 1.24 1.23 1.23 1.23 1.23 1.23 1.23 1.23 1.23 1.23 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.21 1.21 1.21 1.21 1.21 1.21 1.21 1.21 1.21 1.21 1.21 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.18 1.18
1.13 2.31 0.86 0.87 0.06 1.57 1.70 0.54 0.98 0.76 0.69 1.77 0.84 2.10 2.42 0.77 1.25 0.78 0.77 1.01 1.56 2.60 0.81 1.17 0.62 1.22 0.68 0.89 1.19 17.81 1.07 5.84 1.72 1.29 0.90 1.13 1.40 0.33 1.14 2.05 1.88 1.13 0.79 0.65 0.69 1.03 0.72 0.71 1.27 1.06 1.05 1.21 0.81 0.84 1.27 1.16 0.97 0.68 0.66 1.26 0.80 1.29
ACCEPTED MANUSCRIPT
53.3475 40.3435 29.8705 43.155 58.6303 32.0138 57.203 49.1776 46.6701 56.5522 49.8955 16.0622 21.325 73.0333 23.3878 31.4708 41.3635 45.262 41.545 49.6456 36.403 70.0845 47.4306 79.8612 52.5917 17.1801 48.3481 65.7858 105.495 22.5001 30.7865 45.8298 22.9094 69.769 18.6769 46.9658 116.191 48.3468 23.8044 83.993 38.479 58.0112 29.6486 69.9675 24.407 40.0755 46.4099 23.5738 18.6497 17.7139 35.6118 74.5773 63.8682 124.212 40.5022 35.3668 132.029 25.6322 101.25 15.5497 44.6216 18.6303
72.838 70.2759 44.9926 57.5565 59.8707 52.3508 70.9945 38.4101 68.6291 49.9216 72.7654 20.6207 25.9798 104.543 29.142 39.4033 60.6953 66.9429 43.0595 63.8378 56.7828 109.018 71.0328 93.8933 37.1625 19.9833 67.1801 81.2237 113.394 29.203 40.0793 50.8868 24.9929 80.7506 34.9148 52.4824 143.962 60.5524 30.7708 79.7695 37.5507 70.1111 35.4501 72.8958 40.5389 50.5487 82.3499 33.5097 26.7685 18.4242 44.9765 80.0504 76.0166 171.061 50.0029 51.2304 142.399 38.8355 118.122 23.8161 55.6327 21.8959
RI PT
49.2469 53.6568 32.7313 43.3289 46.4644 44.7806 53.1896 36.843 67.6512 39.4391 59.0631 16.1701 16.6316 92.5156 23.6846 33.2979 48.7904 50.7432 32.1925 49.2238 45.1756 91.5689 56.6123 68.8078 44.8688 17.8329 51.5753 73.7237 92.5404 28.3682 35.3976 39.7259 15.8748 58.1949 27.4161 47.8378 120.437 59.7446 27.67 62.3739 35.9653 79.571 27.8578 69.1275 32.9803 38.6945 83.0917 29.2898 30.1801 15.5195 35.1031 57.4419 69.8658 113.124 46.4808 42.5602 92.4313 31.5586 105.738 18.269 48.9524 19.0855
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
TE D
Bysl Uhrf1bp1 Mif4gd Dnmbp Rgl2 Cyhr1 Smg9 Trub1 Parp12 Lcor Lemd2 Pop1 Tgoln2 Cuedc1 Tfip11 Rap1b Usp33 Dennd4a Gm6710 Med24 Oard1 Polr1b Kdm6b Vcan Slc37a2 Ei24 Ddah2 Yipf3 Aars2 Pvrl2 Gas6 Ago2 Stard3 Znf532 Fam208a Git1 Golga7 Prpf18 Tsr1 Mrpl38 Ldlrap1 Cdkn1b Thg1l Wfs1 Orc3 Mib1
ERI3_MOUSE ERI1 exoribonuclease 3 MICA3_MOUSE Protein-methionine sulfoxide oxidase MICAL3 SYNJ1_MOUSE Synaptojanin-1 TSTD3_MOUSE Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3 RDH14_MOUSE Retinol dehydrogenase 14 PKN2_MOUSE Serine/threonine-protein kinase N2 TBG1_MOUSE Tubulin gamma-1 chain PK3CA_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform THRB_MOUSE Prothrombin SDOS_MOUSE Protein syndesmos INO1_MOUSE Inositol-3-phosphate synthase 1 MTA70_MOUSE N6-adenosine-methyltransferase subunit METTL3 NFAT5_MOUSE Nuclear factor of activated T-cells 5 TMM59_MOUSE Transmembrane protein 59 RM52_MOUSE 39S ribosomal protein L52, mitochondrial CB043_MOUSE UPF0554 protein C2orf43 homolog BYST_MOUSE Bystin B2KF50_MOUSE Protein Uhrf1bp1 MI4GD_MOUSE MIF4G domain-containing protein DNMBP_MOUSE Dynamin-binding protein RGL2_MOUSE Ral guanine nucleotide dissociation stimulator-like 2 CYHR1_MOUSE Cysteine and histidine-rich protein 1 SMG9_MOUSE Protein SMG9 TRUB1_MOUSE Probable tRNA pseudouridine synthase 1 PAR12_MOUSE Poly [ADP-ribose] polymerase 12 LCOR_MOUSE Ligand-dependent corepressor LEMD2_MOUSE LEM domain-containing protein 2 Q8K205_MOUSE Blood vessel epicardial substance TGON2_MOUSE Trans-Golgi network integral membrane protein 2 CUED1_MOUSE CUE domain-containing protein 1 TFP11_MOUSE Tuftelin-interacting protein 11 RAP1B_MOUSE Ras-related protein Rap-1b UBP33_MOUSE Ubiquitin carboxyl-terminal hydrolase 33 E9Q8V6_MOUSE Protein Dennd4a A2ART0_MOUSE Protein Gm14391 MED24_MOUSE Mediator of RNA polymerase II transcription subunit 24 OARD1_MOUSE O-acetyl-ADP-ribose deacetylase 1 RPA2_MOUSE DNA-directed RNA polymerase I subunit RPA2 KDM6B_MOUSE Lysine-specific demethylase 6B CSPG2_MOUSE Versican core protein SPX2_MOUSE Sugar phosphate exchanger 2 EI24_MOUSE Etoposide-induced protein 2.4 DDAH2_MOUSE N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 YIPF3_MOUSE Protein YIPF3 SYAM_MOUSE Alanine--tRNA ligase, mitochondrial PVRL2_MOUSE Nectin-2 GAS6_MOUSE Growth arrest-specific protein 6 AGO2_MOUSE Protein argonaute-2 STAR3_MOUSE StAR-related lipid transfer protein 3 ZN532_MOUSE Zinc finger protein 532 F208A_MOUSE Protein FAM208A GIT1_MOUSE ARF GTPase-activating protein GIT1 GOGA7_MOUSE Golgin subfamily A member 7 PRP18_MOUSE Pre-mRNA-splicing factor 18 TSR1_MOUSE Pre-rRNA-processing protein TSR1 homolog RM38_MOUSE 39S ribosomal protein L38, mitochondrial ARH_MOUSE Low density lipoprotein receptor adapter protein 1 CDN1B_MOUSE Cyclin-dependent kinase inhibitor 1B THG1_MOUSE Probable tRNA(His) guanylyltransferase WFS1_MOUSE Wolframin ORC3_MOUSE Origin recognition complex subunit 3 MIB1_MOUSE E3 ubiquitin-protein ligase MIB1
EP
Eri3 Mical3 Synj1 Tstd3 Rdh14 Pkn2 Tubg1 Pik3ca F2 Nudt16l1 Isyna1 Mettl3 Nfat5 Tmem59 Mrpl52
AC C
sp|Q8C460|ERI3_MOUSE sp|Q8CJ19|MICA3_MOUSE sp|Q8CHC4|SYNJ1_MOUSE sp|Q9D0B5|TSTD3_MOUSE sp|Q9ERI6|RDH14_MOUSE sp|Q8BWW9|PKN2_MOUSE sp|P83887|TBG1_MOUSE sp|P42337|PK3CA_MOUSE sp|P19221|THRB_MOUSE sp|Q8VHN8|SDOS_MOUSE sp|Q9JHU9|INO1_MOUSE sp|Q8C3P7|MTA70_MOUSE sp|Q9WV30|NFAT5_MOUSE sp|Q9QY73|TMM59_MOUSE sp|Q9D0Y8|RM52_MOUSE sp|Q8BVA5|CB043_MOUSE sp|O54825|BYST_MOUSE tr|B2KF50|B2KF50_MOUSE sp|Q3UBZ5|MI4GD_MOUSE sp|Q6TXD4|DNMBP_MOUSE sp|Q61193|RGL2_MOUSE sp|Q9QXA1|CYHR1_MOUSE sp|Q9DB90|SMG9_MOUSE sp|Q8C0D0|TRUB1_MOUSE sp|Q8BZ20|PAR12_MOUSE sp|Q6ZPI3|LCOR_MOUSE sp|Q6DVA0|LEMD2_MOUSE tr|Q8K205|Q8K205_MOUSE sp|Q62314|TGON2_MOUSE sp|Q8R3V6|CUED1_MOUSE sp|Q9ERA6|TFP11_MOUSE sp|Q99JI6|RAP1B_MOUSE sp|Q8R5K2|UBP33_MOUSE tr|E9Q8V6|E9Q8V6_MOUSE tr|A2ART0|A2ART0_MOUSE sp|Q99K74|MED24_MOUSE sp|Q8R5F3|OARD1_MOUSE sp|P70700|RPA2_MOUSE sp|Q5NCY0|KDM6B_MOUSE sp|Q62059|CSPG2_MOUSE sp|Q9WU81|SPX2_MOUSE sp|Q61070|EI24_MOUSE sp|Q99LD8|DDAH2_MOUSE sp|Q3UDR8|YIPF3_MOUSE sp|Q14CH7|SYAM_MOUSE sp|P32507|PVRL2_MOUSE sp|Q61592|GAS6_MOUSE sp|Q8CJG0|AGO2_MOUSE sp|Q61542|STAR3_MOUSE sp|Q6NXK2|ZN532_MOUSE sp|Q69ZR9|F208A_MOUSE sp|Q68FF6|GIT1_MOUSE sp|Q91W53|GOGA7_MOUSE sp|Q8BM39|PRP18_MOUSE sp|Q5SWD9|TSR1_MOUSE sp|Q8K2M0|RM38_MOUSE sp|Q8C142|ARH_MOUSE sp|P46414|CDN1B_MOUSE sp|Q9CY52|THG1_MOUSE sp|P56695|WFS1_MOUSE sp|Q9JK30|ORC3_MOUSE sp|Q80SY4|MIB1_MOUSE
48.3083 40.7088 28.8899 44.5011 64.123 38.2476 59.1006 62.8298 65.7168 62.7948 55.1371 17.2116 18.5243 89.5306 26.0242 36.4719 44.8782 45.4476 43.2499 51.8826 38.6666 80.0352 50.4091 79.5169 76.3447 20.7853 49.1636 81.0469 116.884 29.8829 36.7429 48.2527 19.9318 67.3363 18.3494 56.996 128.923 64.026 28.5221 88.6856 48.0979 88.1319 30.6519 86.9853 25.3418 39.8241 66.1964 27.1247 29.1969 19.6154 35.9474 70.9706 76.932 100.185 49.3891 37.8009 114.04 26.2164 117.278 14.6202 50.6534 20.8717
63.3653 27.9192 33.6207 28.1037 44.6839 41.0718 81.8636 25.9498 163.972 98.5601 56.2821 19.5564 32.1111 91.4114 11.8198 39.8135 114.315 42.7285 47.8895 79.4044 55.3143 90.8124 67.1912 75.0363 21.8275 12.6479 60.0848 101.094 149.387 13.4156 47.2505 101.716 15.4384 151.736 73.6572 72.8593 118.519 46.3037 59.6382 41.4237 40.2052 66.0404 141.571 61.599 19.572 45.7333 31.4836 55.378 30.2421 25.5899 25.4979 76.2191 75.3631 155.205 36.1867 34.5125 135.216 25.77 109.009 24.9327 37.0316 17.5498
49.3755 31.8472 23.7461 112.249 51.1019 49.2246 56.4814 47.1755 102.975 39.1253 54.4197 29.9997 7.37015 96.0527 33.6314 40.4259 393.842 43.2449 62.5933 188.381 39.1947 84.4418 25.9943 110.128 50.0988 23.5124 38.8052 99.9378 148.82 41.1913 51.4013 53.9922 34.2367 86.1299 82.0987 54.6544 113.737 42.7081 118.42 178.662 20.6331 63.8228 155.887 59.2475 66.1857 37.5446 29.503 36.3787 21.9586 36.4685 29.9477 147.88 65.8917 129.053 37.0102 59.2647 110.912 32.9655 128.587 10.5539 22.6491 18.7666
1.18 1.18 1.18 1.18 1.18 1.18 1.18 1.18 1.18 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.14 1.14 1.14 1.14 1.14 1.14 1.14 1.14 1.14 1.14 1.14 1.14 1.13
1.10 0.64 0.92 1.62 0.91 1.18 1.25 0.85 2.34 1.43 1.02 1.54 1.04 1.13 0.97 1.24 5.64 0.90 1.50 2.71 1.16 1.08 0.90 1.25 0.74 1.03 0.99 1.44 1.51 1.07 1.49 1.82 1.28 1.86 3.38 1.35 0.98 0.82 3.46 1.50 0.82 0.94 5.17 0.87 1.49 1.06 0.47 1.74 1.07 1.87 0.78 1.70 1.06 1.20 0.84 1.20 1.10 1.03 1.15 1.05 0.64 0.96
ACCEPTED MANUSCRIPT
TE D
32.7779 39.0474 63.7276 34.7995 45.0757 18.7307 44.9331 66.4763 107.78 59.3482 69.0183 49.4912 23.3896 137.333 35.6434 58.5213 47.5583 177.844 18.8001 44.5515 46.8169 144.105 58.665 22.3391 25.2648 57.0954 68.8313 43.8156 45.0932 146.391 130.06 69.9482 71.1652 21.6472 49.3778 35.9637 83.1449 93.3531 19.4247 77.4742 29.1164 14.1506 36.3013 35.2252 17.0601 44.5382 53.1278 41.4031 66.9408 34.3844 58.3084 33.7789 38.466 54.8317 36.9184 32.6602 57.0027 67.4921 81.0191 6.51729 99.7642 33.6723
38.5076 44.668 90.5981 36.764 47.6354 20.2246 60.8327 94.1561 109.575 83.3102 81.544 65.413 35.5297 205.56 47.6849 80.8341 63.6697 160.666 23.6828 64.919 54.6786 158.404 64.4866 19.709 41.1746 63.4722 60.7802 52.2121 64.2493 125.887 174.458 69.361 85.2103 27.1168 61.164 48.4083 85.4541 115.439 24.2509 92.7349 40.7402 19.1937 43.6733 41.4202 26.738 52.3965 82.9758 48.0259 99.2128 53.3526 71.1209 40.9284 51.62 65.42 41.6316 47.3168 63.455 90.9118 103.982 7.46678 139.403 41.4462
SC
RI PT
28.634 37.4091 73.2483 25.2172 35.2749 15.5725 45.866 86.726 115.251 66.8367 75.6636 54.1907 37.2083 163.794 41.6948 69.1471 55.8333 168.881 22.4319 61.9802 51.5364 148.786 49.6012 11.0687 35.2478 62.7048 56.9128 38.6549 50.1277 102.654 131.04 52.4186 83.7823 21.639 53.0911 45.9648 81.113 108.461 18.2975 76.4748 34.7014 18.4604 38.2213 40.2524 25.9711 47.8526 72.8771 37.3003 87.616 45.9265 56.919 34.8499 53.3629 68.8617 35.3589 39.9873 56.5033 84.4216 87.9847 6.0039 124.382 34.5444
M AN U
HDDC2_MOUSE HD domain-containing protein 2 1 E9PY46_MOUSE Protein Ift140 1 KC1G3_MOUSE Casein kinase I isoform gamma-3 1 PEBB_MOUSE Core-binding factor subunit beta 1 WDR7_MOUSE WD repeat-containing protein 7 1 RYR3_MOUSE Ryanodine receptor 3 1 RCD1_MOUSE Cell differentiation protein RCD1 homolog 1 NAL9A_MOUSE NACHT, LRR and PYD domains-containing protein 9A 1 B2RVE2_MOUSE Protein Rergl 1 MFN1_MOUSE Mitofusin-1 1 PYRD1_MOUSE Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 1 UXS1_MOUSE UDP-glucuronic acid decarboxylase 1 1 AT11C_MOUSE Probable phospholipid-transporting ATPase 11C 1 TOR3A_MOUSE Torsin-3A 1 Q7TMC8_MOUSE L-fucose kinase 1 SUMF1_MOUSE Sulfatase-modifying factor 1 1 CAMLG_MOUSE Calcium signal-modulating cyclophilin ligand 1 AP4B1_MOUSE AP-4 complex subunit beta-1 1 C2CD5_MOUSE C2 domain-containing protein 5 1 OSBL3_MOUSE Oxysterol-binding protein-related protein 3 1 RIC8A_MOUSE Synembryn-A 1 GHITM_MOUSE Growth hormone-inducible transmembrane protein 1 ALG13_MOUSE Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG131 HTR5B_MOUSE HEAT repeat-containing protein 5B 1 FOXO3_MOUSE Forkhead box protein O3 1 PTCD1_MOUSE Pentatricopeptide repeat-containing protein 1, mitochondrial 1 NFKB1_MOUSE Nuclear factor NF-kappa-B p105 subunit 1 CO4B_MOUSE Complement C4-B 1 IQCE_MOUSE IQ domain-containing protein E 1 TXND9_MOUSE Thioredoxin domain-containing protein 9 1 D6RGQ8_MOUSE Protein Arhgef11 1 E9PZP8_MOUSE Protein Herc1 1 UB2Q2_MOUSE Ubiquitin-conjugating enzyme E2 Q2 1 TM115_MOUSE Transmembrane protein 115 1 TBC17_MOUSE TBC1 domain family member 17 1 HDAC5_MOUSE Histone deacetylase 5 1 PNISR_MOUSE Arginine/serine-rich protein PNISR 1 NDUB9_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 1 CCD53_MOUSE WASH complex subunit CCDC53 1 ABR_MOUSE Active breakpoint cluster region-related protein 1 MET14_MOUSE N6-adenosine-methyltransferase subunit METTL14 1 MSH6_MOUSE DNA mismatch repair protein Msh6 1 DHX36_MOUSE ATP-dependent RNA helicase DHX36 1 RHG10_MOUSE Rho GTPase-activating protein 10 1 RIR1_MOUSE Ribonucleoside-diphosphate reductase large subunit 1 ATG2B_MOUSE Autophagy-related protein 2 homolog B 1 PDK2_MOUSE [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 1 DOCK8_MOUSE Dedicator of cytokinesis protein 8 1 SPCS1_MOUSE Signal peptidase complex subunit 1 1 PCIF1_MOUSE Phosphorylated CTD-interacting factor 1 1 F6Q8N5_MOUSE Protein Upf3b (Fragment) 1 RUSD2_MOUSE RNA pseudouridylate synthase domain-containing protein 2 1 DP13A_MOUSE DCC-interacting protein 13-alpha 1 TF2H2_MOUSE General transcription factor IIH subunit 2 1 GCFC2_MOUSE GC-rich sequence DNA-binding factor 2 1 HM20A_MOUSE High mobility group protein 20A 1 TULP3_MOUSE Tubby-related protein 3 1 S12A7_MOUSE Solute carrier family 12 member 7 1 UBTD2_MOUSE Ubiquitin domain-containing protein 2 1 B9EJR8_MOUSE HEAT repeat containing 2 1 ASM_MOUSE Sphingomyelin phosphodiesterase 1 RPP40_MOUSE Ribonuclease P protein subunit p40 1
EP
Hddc2 Ift140 Csnk1g3 Cbfb Wdr7 Ryr3 Rqcd1 Nlrp9a Rergl Mfn1 Pyroxd1 Uxs1 Atp11c Tor3a Fuk Sumf1 Camlg Ap4b1 C2cd5 Osbpl3 Ric8a Ghitm Alg13 Heatr5b Foxo3 Ptcd1 Nfkb1 C4b Iqce Txndc9 Arhgef11 Herc1 Ube2q2 Tmem115 Tbc1d17 Hdac5 Pnisr Ndufb9 Ccdc53 Abr Mettl14 Msh6 Dhx36 Arhgap10 Rrm1 Atg2b Pdk2 Dock8 Spcs1 Pcif1 Upf3b Rpusd2 Appl1 Gtf2h2 Gcfc2 Hmg20a Tulp3 Slc12a7 Ubtd2 Heatr2 Smpd1 Rpp40
AC C
sp|Q3SXD3|HDDC2_MOUSE tr|E9PY46|E9PY46_MOUSE sp|Q8C4X2|KC1G3_MOUSE sp|Q08024|PEBB_MOUSE sp|Q920I9|WDR7_MOUSE sp|A2AGL3|RYR3_MOUSE sp|Q9JKY0|RCD1_MOUSE sp|Q66X03|NAL9A_MOUSE tr|B2RVE2|B2RVE2_MOUSE sp|Q811U4|MFN1_MOUSE sp|Q3TMV7|PYRD1_MOUSE sp|Q91XL3|UXS1_MOUSE sp|Q9QZW0|AT11C_MOUSE sp|Q9ER38|TOR3A_MOUSE tr|Q7TMC8|Q7TMC8_MOUSE sp|Q8R0F3|SUMF1_MOUSE sp|P49070|CAMLG_MOUSE sp|Q9WV76|AP4B1_MOUSE sp|Q7TPS5|C2CD5_MOUSE sp|Q9DBS9|OSBL3_MOUSE sp|Q3TIR3|RIC8A_MOUSE sp|Q91VC9|GHITM_MOUSE sp|Q9D8C3|ALG13_MOUSE sp|Q8C547|HTR5B_MOUSE sp|Q9WVH4|FOXO3_MOUSE sp|Q8C2E4|PTCD1_MOUSE sp|P25799|NFKB1_MOUSE sp|P01029|CO4B_MOUSE sp|Q6PCQ0|IQCE_MOUSE sp|Q9CQ79|TXND9_MOUSE tr|D6RGQ8|D6RGQ8_MOUSE tr|E9PZP8|E9PZP8_MOUSE sp|Q8K2Z8|UB2Q2_MOUSE sp|Q9WUH1|TM115_MOUSE sp|Q8BYH7|TBC17_MOUSE sp|Q9Z2V6|HDAC5_MOUSE sp|A2AJT4|PNISR_MOUSE sp|Q9CQJ8|NDUB9_MOUSE sp|Q9CR27|CCD53_MOUSE sp|Q5SSL4|ABR_MOUSE sp|Q3UIK4|MET14_MOUSE sp|P54276|MSH6_MOUSE sp|Q8VHK9|DHX36_MOUSE sp|Q6Y5D8|RHG10_MOUSE sp|P07742|RIR1_MOUSE sp|Q80XK6|ATG2B_MOUSE sp|Q9JK42|PDK2_MOUSE sp|Q8C147|DOCK8_MOUSE sp|Q9D958|SPCS1_MOUSE sp|P59114|PCIF1_MOUSE tr|F6Q8N5|F6Q8N5_MOUSE sp|Q149F1|RUSD2_MOUSE sp|Q8K3H0|DP13A_MOUSE sp|Q9JIB4|TF2H2_MOUSE sp|Q8BKT3|GCFC2_MOUSE sp|Q9DC33|HM20A_MOUSE sp|O88413|TULP3_MOUSE sp|Q9WVL3|S12A7_MOUSE sp|Q6PGH0|UBTD2_MOUSE tr|B9EJR8|B9EJR8_MOUSE sp|Q04519|ASM_MOUSE sp|Q8R1F9|RPP40_MOUSE
31.0849 41.9678 64.5945 31.2272 43.3729 18.5428 41.7606 78.8392 142.18 58.9891 81.5691 51.4709 32.7629 133.512 39.3172 62.768 52.5898 229.193 22.6103 54.6343 55.5741 169.423 56.5323 17.6222 26.4258 70.3192 79.6476 39.8506 41.9884 151.968 116.664 67.0426 86.7636 20.9097 52.5133 42.4572 96.5445 108.148 17.508 77.5415 29.839 16.8706 38.6078 41.8598 20.729 49.4438 55.8097 38.6562 70.9313 35.0009 55.5677 34.525 49.3168 70.3929 37.6861 32.368 60.9959 75.3756 80.9984 6.22691 105.726 33.1287
5.34436 37.5747 64.2595 34.2059 51.1013 15.615 46.1969 0.745896 145.881 41.0545 75.1826 41.7604 24.42 83.2748 58.6991 46.2256 44.3157 241.334 24.548 65.3654 60.713 281.331 48.0221 22.4252 27.3255 53.1842 89.8929 30.8338 39.0314 137.126 196.311 68.457 74.531 22.2513 80.4934 33.7364 15.7735 119.834 13.5163 61.9209 29.5329 22.1826 32.4502 41.2891 31.7496 31.5512 59.343 34.3307 73.9217 61.2046 39.0345 26.2862 28.1341 83.2273 34.3712 14.4788 53.7509 67.4064 100.386 119.456 82.5419 38.5176
37.5419 40.7233 43.2842 67.2434 40.4317 22.8789 54.6843 0 91.9195 35.034 67.3555 67.0675 23.4705 42.9329 51.3131 113.48 62.1434 190.369 23.3977 71.5948 44.1532 150.841 104.73 17.2422 25.6942 90.6522 136.057 45.4812 50.0924 204.735 350.88 52.1218 95.8775 11.3413 90.2272 107.211 43.0261 147.613 31.4267 66.8166 40.7482 8.87713 31.9983 31.0254 11.9869 41.6799 86.9743 82.4145 71.1565 32.7267 93.5756 39.4559 29.0526 61.7835 34.7438 36.226 94.4173 60.0757 167.932 50.6182 104 29.8211
1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09
0.70 1.02 0.79 1.69 1.14 1.12 1.11 0.00 1.07 0.60 0.99 1.05 0.79 0.42 1.42 1.25 1.03 1.25 1.16 1.29 1.07 1.48 1.41 1.19 0.88 1.20 1.80 0.93 0.94 1.37 2.10 0.99 1.10 0.78 1.67 1.72 0.36 1.33 1.19 0.84 1.10 0.95 0.86 0.96 1.02 0.79 1.16 1.48 0.94 1.17 1.15 0.96 0.62 1.17 0.96 0.70 1.31 0.84 1.59 13.58 0.83 1.00
ACCEPTED MANUSCRIPT
56.7534 57.564 13.0434 62.4068 77.6896 58.667 24.2854 57.544 93.1461 17.2678 59.7264 125.641 44.9006 62.9367 5.05354 59.0616 36.3885 37.2543 45.0222 42.5484 50.6584 26.0584 46.9744 42.2303 71.9464 48.8387 17.9127 43.6815 47.2121 35.8153 32.7893 30.4896 51.2397 89.6524 28.3977 29.7256 47.9189 66.3345 29.3257 37.945 46.1279 37.7507 66.1524 116.085 43.9808 57.5068 16.4975 62.6575 58.8711 31.8775 13.9819 74.1983 17.3386 106.356 95.2664 9.31011 43.4112 44.5651 53.7368 55.8541 18.8564 52.8135
79.0056 29.6355 19.4039 56.6256 77.6044 74.6152 27.7713 67.4836 120.79 23.4987 85.0641 144.311 55.6848 75.5789 7.81709 82.5775 61.0445 43.3832 48.0031 54.2731 49.905 31.3095 28.2264 54.5784 93.4341 63.6964 23.2184 30.703 62.8497 42.8456 37.1419 30.7651 62.2489 103.279 30.5623 33.6858 45.5775 102.596 34.3583 43.8603 63.3282 47.9089 76.6594 128.05 56.7486 71.4654 15.8404 55.4789 71.4079 38.3217 13.828 89.7341 21.5784 103.827 104.373 13.7597 47.8404 46.5565 47.5713 60.2849 20.1522 67.1603
SC
RI PT
81.1819 44.8123 19.8866 39.6186 52.644 66.1456 21.0364 55.7149 104.593 19.6991 76.493 124.785 48.4037 79.0175 5.71617 74.6794 54.2299 36.0888 39.1748 49.4261 42.5402 29.444 37.0469 47.474 88.3869 47.481 19.9841 21.3751 52.5148 35.1225 29.4807 28.6656 56.8912 87.4159 31.3903 31.6779 45.7434 92.0627 27.1887 44.4887 63.9855 44.8068 68.213 116.13 55.143 59.0961 12.4863 51.8554 56.603 34.4331 10.0271 77.8777 18.1486 118.255 91.9071 10.3357 45.1914 36.1969 48.0038 46.1409 14.241 56.9126
M AN U
Pde6d Hm13 Mtmr12 Acss3 Tpst2 Tmem11 Alas1 Degs1 Snx15 Ift46 Slc30a1 Nkiras2 Bms1 Pon3 Edc4 Hspbp1 Paox Patl1 Smarcd1 Samd4b Mepce Slc25a36 Spats2 Kat7 Smarcb1 Pptc7 Map1lc3a Ing3 Urm1 Adat2 Nrip1 Atp2c1 Vti1b Dph2 Tmpo Wipi1 Sh3d19 Cbfa2t3 Zfand1 Trps1 Aprt
TE D
Arid1b Ltv1 Mtr
WDR92_MOUSE WD repeat-containing protein 92 1 RRN3_MOUSE RNA polymerase I-specific transcription initiation factor RRN3 1 MIO_MOUSE WD repeat-containing protein mio 1 J3QMK2_MOUSE MCG22959, isoform CRA_a 1 MYPT2_MOUSE Protein phosphatase 1 regulatory subunit 12B 1 SPTC2_MOUSE Serine palmitoyltransferase 2 1 SWAHC_MOUSE Ankyrin repeat domain-containing protein SOWAHC 1 KTHY_MOUSE Thymidylate kinase 1 ITIH4_MOUSE Inter alpha-trypsin inhibitor, heavy chain 4 1 XRCC1_MOUSE DNA repair protein XRCC1 1 MERL_MOUSE Merlin 1 E9QJT3_MOUSE Vesicle transport protein SFT2C 1 ITSN2_MOUSE Intersectin-2 1 MPV17_MOUSE Protein Mpv17 1 TBC24_MOUSE TBC1 domain family member 24 1 MET16_MOUSE Methyltransferase-like protein 16 1 CD051_MOUSE Uncharacterized protein C4orf51 homolog 1 E9Q4N6_MOUSE Protein Arid1b 1 LTV1_MOUSE Protein LTV1 homolog 1 METH_MOUSE Methionine synthase 1 CG055_MOUSE UPF0562 protein C7orf55 homolog 1 PDE6D_MOUSE Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta 1 HM13_MOUSE Minor histocompatibility antigen H13 1 MTMRC_MOUSE Myotubularin-related protein 12 1 ACSS3_MOUSE Acyl-CoA synthetase short-chain family member 3, mitochondrial 1 TPST2_MOUSE Protein-tyrosine sulfotransferase 2 1 TMM11_MOUSE Transmembrane protein 11, mitochondrial 1 HEM1_MOUSE 5-aminolevulinate synthase, nonspecific, mitochondrial 1 DEGS1_MOUSE Sphingolipid delta(4)-desaturase DES1 1 SNX15_MOUSE Sorting nexin-15 1 IFT46_MOUSE Intraflagellar transport protein 46 homolog 1 ZNT1_MOUSE Zinc transporter 1 1 KBRS2_MOUSE NF-kappa-B inhibitor-interacting Ras-like protein 2 1 Q6PGF5_MOUSE BMS1 homolog, ribosome assembly protein (Yeast) 1 PON3_MOUSE Serum paraoxonase/lactonase 3 1 EDC4_MOUSE Enhancer of mRNA-decapping protein 4 1 HPBP1_MOUSE Hsp70-binding protein 1 1 PAOX_MOUSE Peroxisomal N(1)-acetyl-spermine/spermidine oxidase 1 PATL1_MOUSE Protein PAT1 homolog 1 1 SMRD1_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily 1 D member 1 SMAG2_MOUSE Protein Smaug homolog 2 1 MEPCE_MOUSE 7SK snRNA methylphosphate capping enzyme 1 S2536_MOUSE Solute carrier family 25 member 36 1 SPAS2_MOUSE Spermatogenesis-associated serine-rich protein 2 1 KAT7_MOUSE Histone acetyltransferase KAT7 1 SNF5_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B 1member 1 PPTC7_MOUSE Protein phosphatase PTC7 homolog 1 MLP3A_MOUSE Microtubule-associated proteins 1A/1B light chain 3A 1 ING3_MOUSE Inhibitor of growth protein 3 1 URM1_MOUSE Ubiquitin-related modifier 1 1 ADAT2_MOUSE tRNA-specific adenosine deaminase 2 1 NRIP1_MOUSE Nuclear receptor-interacting protein 1 1 AT2C1_MOUSE Calcium-transporting ATPase type 2C member 1 1 VTI1B_MOUSE Vesicle transport through interaction with t-SNAREs homolog 1B 1 DPH2_MOUSE Diphthamide biosynthesis protein 2 1 LAP2A_MOUSE Lamina-associated polypeptide 2, isoforms alpha/zeta 1 WIPI1_MOUSE WD repeat domain phosphoinositide-interacting protein 1 1 SH319_MOUSE SH3 domain-containing protein 19 1 MTG16_MOUSE Protein CBFA2T3 1 ZFAN1_MOUSE AN1-type zinc finger protein 1 1 TRPS1_MOUSE Zinc finger transcription factor Trps1 1 APT_MOUSE Adenine phosphoribosyltransferase 1
EP
Wdr92 Rrn3 Mios Bbip1 Ppp1r12b Sptlc2 Sowahc Dtymk Itih4 Xrcc1 Nf2 Sft2d3 Itsn2 Mpv17 Tbc1d24 Mettl16
AC C
sp|Q8BGF3|WDR92_MOUSE sp|B2RS91|RRN3_MOUSE sp|Q8VE19|MIO_MOUSE tr|J3QMK2|J3QMK2_MOUSE sp|Q8BG95|MYPT2_MOUSE sp|P97363|SPTC2_MOUSE sp|Q8C0J6|SWAHC_MOUSE sp|P97930|KTHY_MOUSE sp|A6X935|ITIH4_MOUSE sp|Q60596|XRCC1_MOUSE sp|P46662|MERL_MOUSE tr|E9QJT3|E9QJT3_MOUSE sp|Q9Z0R6|ITSN2_MOUSE sp|P19258|MPV17_MOUSE sp|Q3UUG6|TBC24_MOUSE sp|Q9CQG2|MET16_MOUSE sp|Q9DAF8|CD051_MOUSE tr|E9Q4N6|E9Q4N6_MOUSE sp|Q6NSQ7|LTV1_MOUSE sp|A6H5Y3|METH_MOUSE sp|Q9CR13|CG055_MOUSE sp|O55057|PDE6D_MOUSE sp|Q9D8V0|HM13_MOUSE sp|Q80TA6|MTMRC_MOUSE sp|Q14DH7|ACSS3_MOUSE sp|O88856|TPST2_MOUSE sp|Q8BK08|TMM11_MOUSE sp|Q8VC19|HEM1_MOUSE sp|O09005|DEGS1_MOUSE sp|Q91WE1|SNX15_MOUSE sp|Q9DB07|IFT46_MOUSE sp|Q60738|ZNT1_MOUSE sp|Q9CR56|KBRS2_MOUSE tr|Q6PGF5|Q6PGF5_MOUSE sp|Q62087|PON3_MOUSE sp|Q3UJB9|EDC4_MOUSE sp|Q99P31|HPBP1_MOUSE sp|Q8C0L6|PAOX_MOUSE sp|Q3TC46|PATL1_MOUSE sp|Q61466|SMRD1_MOUSE sp|Q80XS6|SMAG2_MOUSE sp|Q8K3A9|MEPCE_MOUSE sp|Q922G0|S2536_MOUSE sp|Q8K1N4|SPAS2_MOUSE sp|Q5SVQ0|KAT7_MOUSE sp|Q9Z0H3|SNF5_MOUSE sp|Q6NVE9|PPTC7_MOUSE sp|Q91VR7|MLP3A_MOUSE sp|Q8VEK6|ING3_MOUSE sp|Q9D2P4|URM1_MOUSE sp|Q6P6J0|ADAT2_MOUSE sp|Q8CBD1|NRIP1_MOUSE sp|Q80XR2|AT2C1_MOUSE sp|O88384|VTI1B_MOUSE sp|Q9CR25|DPH2_MOUSE sp|Q61033|LAP2A_MOUSE sp|Q8R3E3|WIPI1_MOUSE sp|Q91X43|SH319_MOUSE sp|O54972|MTG16_MOUSE sp|Q8BFR6|ZFAN1_MOUSE sp|Q925H1|TRPS1_MOUSE sp|P08030|APT_MOUSE
71.5329 82.0419 16.5176 54.6412 64.4577 61.2837 21.5727 55.8235 94.4245 16.7067 63.0466 127.904 45.6931 78.6176 3.87259 62.5772 37.2074 36.0168 43.1421 45.2684 50.9564 28.6527 62.5395 42.2762 79.5599 40.0888 17.5953 39.3215 44.4635 33.476 29.844 32.8262 53.979 87.0252 33.6635 32.2169 54.9466 67.3414 26.2595 44.4178 54.4353 40.3563 66.9579 119.963 49.1182 53.0501 15.095 66.6939 51.7577 32.379 11.7447 72.1798 16.1936 135.224 94.8208 7.13976 46.3913 39.229 60.4891 47.9463 14.9483 49.189
95.5799 36.0987 16.3148 35.7147 62.084 79.297 14.9398 22.9215 46.5481 5.50236 29.7222 133.71 45.7807 69.9232 199.317 26.6098 57.9174 36.7252 22.1887 44.7326 30.986 20.9639 49.5044 38.4231 26.8316 41.7567 132.917 129.976 36.1558 22.5853 24.8195 43.9745 34.2869 30.4506 39.8338 45.5896 64.0231 69.9774 27.1241 44.666 24.5848 22.8843 38.7768 97.9552 39.5878 57.0436 23.3311 60.6102 56.3085 24.1381 167.476 34.8956 18.759 108.121 83.1194 126.329 37.2379 16.6957 52.8645 28.4032 20.5875 84.9192
85.0304 53.0563 21.1717 119.824 143.746 65.4444 27.0475 69.1439 326.595 0 20.2619 98.9008 57.7703 69.005 467.807 63.8859 57.5801 58.7691 71.0272 46.6607 44.4097 35.1871 40.0638 77.627 79.7441 34.203 119.459 173.371 54.1039 57.8854 36.4432 44.6723 76.0267 13.8124 43.814 24.8991 52.3266 68.3272 23.5866 63.8558 51.5389 51.6394 31.7258 47.8549 40.3239 51.5278 87.9179 72.0662 136.032 53.3082 242.892 234.197 12.1023 81.724 258.315 116.794 51.9943 26.2805 117.598 41.7963 32.6455 63.4609
1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06
1.31 0.87 1.14 1.52 1.58 1.16 0.93 0.81 1.89 0.15 0.37 0.93 1.11 0.98 61.94 0.68 1.27 1.30 1.11 0.99 0.81 1.01 1.07 1.29 0.66 0.79 6.66 4.66 0.91 1.13 0.98 1.50 1.02 0.25 1.40 1.15 1.24 0.87 0.90 1.32 0.69 0.90 0.52 0.63 0.81 0.93 3.84 1.16 1.67 1.17 17.09 1.77 0.87 0.85 1.82 12.38 1.01 0.53 1.68 0.69 1.61 1.35
ACCEPTED MANUSCRIPT
TE D
24.7223 49.9818 65.6909 73.3688 91.8083 63.6731 86.2036 29.0853 31.3449 35.4851 53.4088 30.0437 32.021 30.7729 72.7953 58.7199 72.9767 44.96 32.2608 57.0622 69.3474 63.5984 20.999 26.4577 29.2097 56.4846 24.3739 65.1614 70.1788 43.2631 66.5134 32.5633 46.7311 55.8909 68.3034 60.0479 25.6039 47.5874 18.5173 43.2215 36.7468 36.2543 96.9127 63.3499 59.1485 42.4941 33.5278 31.5635 83.7558 32.7495 70.0492 10.9411 38.243 47.4658 37.8277 64.1285 42.4663 27.287 36.2278 22.5526 83.0713 38.5479
26.6341 47.8526 43.8161 69.6175 99.428 57.4998 101.496 37.9457 29.6348 39.6884 74.6928 39.169 39.5803 39.413 91.2775 63.9089 73.5585 57.3608 37.4837 73.8257 95.3802 73.3576 23.3219 41.2969 34.7733 67.8414 29.8453 84.9953 89.5178 72.9273 55.9356 44.157 56.3401 56.5089 90.2252 59.3725 32.3286 47.047 24.6702 50.0048 35.266 50.5325 101.505 71.6343 77.0409 56.8477 36.2886 42.8105 90.3953 33.0746 85.2039 10.1172 40.7172 47.9852 44.427 76.7454 42.8804 30.713 40.3149 27.4758 106.886 39.1144
RI PT
19.0789 43.5978 63.7598 58.4626 80.6755 74.1092 76.4195 42.6361 30.2969 28.53 65.4378 35.1737 29.4831 30.5827 81.4043 57.823 88.3027 56.8811 26.7845 66.6676 86.9351 61.982 16.2418 37.9569 33.8334 55.5455 22.7745 76.1703 78.5915 66.2177 55.7602 34.0449 54.0414 53.1303 81.9892 65.3628 29.1306 38.547 22.4323 44.9428 42.7235 42.9192 81.7303 65.9959 59.8616 54.0078 30.315 38.0837 70.5214 24.0249 72.4615 11.2647 35.3437 39.379 42.308 73.8532 38.5542 28.7225 42.9534 27.464 99.0266 35.0734
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
TDRD3_MOUSE Tudor domain-containing protein 3 LLPH_MOUSE Protein LLP homolog RL18A_MOUSE 60S ribosomal protein L18a CTC1_MOUSE CST complex subunit CTC1 A2ANC1_MOUSE Tyrosine-protein phosphatase non-receptor type substrate 1 (Fragment) RN123_MOUSE E3 ubiquitin-protein ligase RNF123 GREM1_MOUSE Gremlin-1 TMM65_MOUSE Transmembrane protein 65 GID4_MOUSE Glucose-induced degradation protein 4 homolog LIMD1_MOUSE LIM domain-containing protein 1 GPN1_MOUSE GPN-loop GTPase 1 NAA25_MOUSE N-alpha-acetyltransferase 25, NatB auxiliary subunit PTN2_MOUSE Tyrosine-protein phosphatase non-receptor type 2 ADXL_MOUSE Adrenodoxin-like protein, mitochondrial NUP37_MOUSE Nucleoporin Nup37 A6ZI47_MOUSE Fructose-bisphosphate aldolase TM7S3_MOUSE Transmembrane 7 superfamily member 3 PRP39_MOUSE Pre-mRNA-processing factor 39 HPCL1_MOUSE Hippocalcin-like protein 1 E9Q6H8_MOUSE Protein Plekha5 TAF5_MOUSE Transcription initiation factor TFIID subunit 5 CANT1_MOUSE Soluble calcium-activated nucleotidase 1 CSTF1_MOUSE Cleavage stimulation factor subunit 1 CTL1_MOUSE Choline transporter-like protein 1 COMD6_MOUSE COMM domain-containing protein 6 GPKOW_MOUSE G patch domain and KOW motifs-containing protein U119B_MOUSE Protein unc-119 homolog B EMAL2_MOUSE Echinoderm microtubule-associated protein-like 2 G45IP_MOUSE Growth arrest and DNA damage-inducible proteins-interacting protein 1 TLL2_MOUSE Tolloid-like protein 2 VPS52_MOUSE Vacuolar protein sorting-associated protein 52 homolog XRN2_MOUSE 5'-3' exoribonuclease 2 CDKL3_MOUSE Cyclin-dependent kinase-like 3 MTRR_MOUSE Methionine synthase reductase EXOS5_MOUSE Exosome complex component RRP46 CDS2_MOUSE Phosphatidate cytidylyltransferase 2 RBM40_MOUSE RNA-binding protein 40 BI1_MOUSE Bax inhibitor 1 RPC3_MOUSE DNA-directed RNA polymerase III subunit RPC3 TPC10_MOUSE Trafficking protein particle complex subunit 10 TLR3_MOUSE Toll-like receptor 3 FMR1_MOUSE Isoform ISO10 of Fragile X mental retardation protein 1 homolog FKB14_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP14 GGPPS_MOUSE Geranylgeranyl pyrophosphate synthase WIZ_MOUSE Protein Wiz GDAP2_MOUSE Ganglioside-induced differentiation-associated protein 2 RFOX3_MOUSE RNA binding protein fox-1 homolog 3 E9Q4Z2_MOUSE Protein Acacb RT63_MOUSE Ribosomal protein 63, mitochondrial CIAO1_MOUSE Probable cytosolic iron-sulfur protein assembly protein CIAO1 THTPA_MOUSE Thiamine-triphosphatase U2AF1_MOUSE Splicing factor U2AF 35 kDa subunit HSC20_MOUSE Iron-sulfur cluster co-chaperone protein HscB, mitochondrial LUZP1_MOUSE Leucine zipper protein 1 RT35_MOUSE 28S ribosomal protein S35, mitochondrial ASCC1_MOUSE Activating signal cointegrator 1 complex subunit 1 GBG2_MOUSE Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 WRIP1_MOUSE ATPase WRNIP1 ARRB1_MOUSE Beta-arrestin-1 DNM3A_MOUSE DNA (cytosine-5)-methyltransferase 3A INT9_MOUSE Integrator complex subunit 9 TIP_MOUSE T-cell immunomodulatory protein
EP
Tdrd3 Llph Rpl18a Ctc1 Sirpa Rnf123 Grem1 Tmem65 Gid4 Limd1 Gpn1 Naa25 Ptpn2 Fdx1l Nup37 Aldoart2 Tm7sf3 Prpf39 Hpcal1 Plekha5 Taf5 Cant1 Cstf1 Slc44a1 Commd6 Gpkow Unc119b Eml2 Gadd45gip1 Tll2 Vps52 Xrn2 Cdkl3 Mtrr Exosc5 Cds2 Rnpc3 Tmbim6 Polr3c Trappc10 Tlr3 Fmr1 Fkbp14 Ggps1 Wiz Gdap2 Rbfox3 Acacb Mrpl57 Ciao1 Thtpa U2af1 Hscb Luzp1 Mrps35 Ascc1 Gng2 Wrnip1 Arrb1 Dnmt3a Ints9 Itfg1
AC C
sp|Q91W18|TDRD3_MOUSE sp|Q9D945|LLPH_MOUSE sp|P62717|RL18A_MOUSE sp|Q5SUQ9|CTC1_MOUSE tr|A2ANC1|A2ANC1_MOUSE sp|Q5XPI3|RN123_MOUSE sp|O70326|GREM1_MOUSE sp|Q4VAE3|TMM65_MOUSE sp|Q9CPY6|GID4_MOUSE sp|Q9QXD8|LIMD1_MOUSE sp|Q8VCE2|GPN1_MOUSE sp|Q8BWZ3|NAA25_MOUSE sp|Q06180|PTN2_MOUSE sp|Q9CPW2|ADXL_MOUSE sp|Q9CWU9|NUP37_MOUSE tr|A6ZI47|A6ZI47_MOUSE sp|Q9CRG1|TM7S3_MOUSE sp|Q8K2Z2|PRP39_MOUSE sp|P62748|HPCL1_MOUSE tr|E9Q6H8|E9Q6H8_MOUSE sp|Q8C092|TAF5_MOUSE sp|Q8VCF1|CANT1_MOUSE sp|Q99LC2|CSTF1_MOUSE sp|Q6X893|CTL1_MOUSE sp|Q3V4B5|COMD6_MOUSE sp|Q56A08|GPKOW_MOUSE sp|Q8C4B4|U119B_MOUSE sp|Q7TNG5|EMAL2_MOUSE sp|Q9CR59|G45IP_MOUSE sp|Q9WVM6|TLL2_MOUSE sp|Q8C754|VPS52_MOUSE sp|Q9DBR1|XRN2_MOUSE sp|Q8BLF2|CDKL3_MOUSE sp|Q8C1A3|MTRR_MOUSE sp|Q9CRA8|EXOS5_MOUSE sp|Q99L43|CDS2_MOUSE sp|Q3UZ01|RBM40_MOUSE sp|Q9D2C7|BI1_MOUSE sp|Q9D483|RPC3_MOUSE sp|Q3TLI0|TPC10_MOUSE sp|Q99MB1|TLR3_MOUSE sp|P35922-10|FMR1_MOUSE sp|P59024|FKB14_MOUSE sp|Q9WTN0|GGPPS_MOUSE sp|O88286|WIZ_MOUSE sp|Q9DBL2|GDAP2_MOUSE sp|Q8BIF2|RFOX3_MOUSE tr|E9Q4Z2|E9Q4Z2_MOUSE sp|Q9CQF8|RT63_MOUSE sp|Q99KN2|CIAO1_MOUSE sp|Q8JZL3|THTPA_MOUSE sp|Q9D883|U2AF1_MOUSE sp|Q8K3A0|HSC20_MOUSE sp|Q8R4U7|LUZP1_MOUSE sp|Q8BJZ4|RT35_MOUSE sp|Q9D8Z1|ASCC1_MOUSE sp|P63213|GBG2_MOUSE sp|Q91XU0|WRIP1_MOUSE sp|Q8BWG8|ARRB1_MOUSE sp|O88508|DNM3A_MOUSE sp|Q8K114|INT9_MOUSE sp|Q99KW9|TIP_MOUSE
19.8076 51.3599 93.3872 70.0954 83.3318 88.453 70.7447 38.012 35.5843 28.0364 50.9638 29.7144 25.3643 25.2926 71.2257 58.8611 95.9424 49.6628 24.5655 56.0959 68.6225 58.3655 15.7357 26.2354 31.3184 49.4963 19.5127 62.9079 66.1694 41.6158 71.9888 25.47 48.9885 57.401 66.4443 71.348 24.6854 42.5993 17.8716 41.5389 47.1893 31.5838 83.738 62.4155 46.1274 43.0169 29.6705 29.1382 68.9544 25.5603 61.9716 12.8069 35.2294 41.5798 38.2078 65.3256 40.5354 26.944 41.1588 23.9709 80.388 36.587
19.5546 36.9515 47.1651 80.4491 7.72037 55.6471 113.412 46.5349 31.3418 110.145 48.1066 30.5973 43.5636 13.2832 108.162 111.782 32.9464 59.7201 30.5641 46.7422 67.3804 40.1788 53.6128 14.9867 42.5869 166.425 154.573 91.8816 34.7261 29.7876 32.0733 24.8583 37.0299 65.4006 85.2033 61.0269 14.293 80.0469 21.9512 68.9665 48.287 30.6521 48.8361 53.8999 55.7861 71.2117 40.9488 36.331 40.2034 68.2863 45.5845 86.827 28.418 40.3208 29.6454 63.2153 51.5899 22.8152 38.4574 16.0168 107.339 41.6533
37.4478 98.8619 41.7878 85.0723 12.0052 45.5805 87.1451 51.8644 36.2068 283.586 48.9381 24.1342 41.0647 54.0712 100.141 112.279 42.7048 40.9789 55.4607 102.49 38.2974 30.5464 58.6997 7.4731 106.31 324.446 72.2531 85.5482 78.6939 48.1679 44.599 18.1007 38.3535 81.6554 71.8195 50.9941 33.7486 69.7889 11.7064 56.3273 26.4995 44.084 118.49 81.2597 75.2973 105.883 87.416 29.21 99.722 142.251 99.5568 133.16 67.6357 108.496 73.3036 81.3414 58.4955 15.0282 33.2688 14.9201 117.426 35.3178
1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03
1.30 1.45 0.69 1.26 0.11 0.73 1.23 1.37 1.10 6.15 0.82 0.84 1.38 1.10 1.35 1.92 0.47 0.99 1.46 1.21 0.68 0.56 3.02 0.35 2.36 4.38 4.81 1.26 0.76 0.71 0.63 0.64 0.75 1.35 1.04 0.89 0.88 1.74 0.82 1.42 0.94 0.94 0.94 1.04 1.10 1.84 2.01 0.94 0.91 3.71 1.02 9.91 1.31 1.71 1.28 1.05 1.36 0.68 0.91 0.62 1.23 1.05
ACCEPTED MANUSCRIPT
TE D
56.6389 33.9206 45.7245 49.7757 34.6656 60.5144 29.1569 80.7973 24.6885 79.5891 83.4663 57.6984 51.3602 99.3534 39.167 42.718 25.8664 73.5275 42.0859 47.7643 44.8655 22.552 38.5141 49.3118 19.9142 47.3467 56.207 81.2824 26.5784 33.9935 106.132 51.0424 37.543 67.6235 78.695 26.23 54.681 41.5922 39.1407 36.3923 87.4371 51.4318 39.6571 9.91263 17.6189 47.7002 26.8368 149.773 75.6729 164.14 109.623 35.723 35.262 80.6917 21.6726 46.1123 53.6221 49.7879 30.9715 50.9652 19.3661 34.7362
55.9003 45.4857 50.7666 57.8058 40.0475 64.1075 37.7046 36.745 22.3168 90.23 83.5931 65.7448 46.2593 98.4074 31.5338 47.1657 30.7057 77.6201 39.3007 62.5267 35.6929 17.5507 42.5691 68.0347 20.6303 47.7276 69.012 80.5377 26.4265 32.9396 92.6494 52.1049 40.9941 75.9374 77.3311 27.1383 57.6523 44.8108 52.5547 27.0023 51.6842 60.6219 41.5181 14.946 24.4031 51.2343 30.6508 163.843 91.9444 144.299 119.907 41.9614 26.4356 92.0734 31.0371 48.0588 54.2265 46.8559 41.6228 46.992 23.7242 41.5131
RI PT
58.4847 43.7572 45.4359 56.473 30.5746 55.4453 42.617 30.1267 18.9903 85.898 92.1614 59.2845 52.3024 92.1688 23.9965 34.9449 26.1498 65.7145 36.1443 55.181 47.887 13.3904 39.1044 62.2578 18.5404 43.1498 64.7808 79.5679 25.4921 31.6238 118.935 54.3664 39.8145 67.1002 72.5068 24.1578 60.7017 38.7265 49.1965 43.1744 62.797 55.7943 42.3911 15.2848 25.9228 52.753 33.0546 137.014 86.2954 131.257 139.438 41.648 21.8813 83.0248 32.4086 43.7046 56.8645 42.217 41.5862 48.0857 21.3986 34.5513
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
COMD2_MOUSE COMM domain-containing protein 2 Q9JHF5_MOUSE A3 subunit of vacuolar-adenosine triphosphatase NT5M_MOUSE 5'(3')-deoxyribonucleotidase, mitochondrial MMP14_MOUSE Matrix metalloproteinase-14 MED4_MOUSE Mediator of RNA polymerase II transcription subunit 4 BCL10_MOUSE B-cell lymphoma/leukemia 10 LIPT_MOUSE Lipoyltransferase 1, mitochondrial CDN1A_MOUSE Cyclin-dependent kinase inhibitor 1 E2F5_MOUSE Transcription factor E2F5 SMYD2_MOUSE N-lysine methyltransferase SMYD2 APC7_MOUSE Anaphase-promoting complex subunit 7 LAS1L_MOUSE Ribosomal biogenesis protein LAS1L SUN1_MOUSE SUN domain-containing protein 1 PX11B_MOUSE Peroxisomal membrane protein 11B ENC1_MOUSE Ectoderm-neural cortex protein 1 DEUP1_MOUSE Deuterosome protein 1 Q810Y9_MOUSE PRAMEl6 AVEN_MOUSE Cell death regulator Aven CETN2_MOUSE Centrin-2 F6UFZ5_MOUSE Protein Pcf11 (Fragment) TBCK_MOUSE TBC domain-containing protein kinase-like protein G3UW66_MOUSE MCG120086 EXOS8_MOUSE Exosome complex component RRP43 ACY2_MOUSE Aspartoacylase UBAP2_MOUSE Ubiquitin-associated protein 2 Q91XX1_MOUSE Protein Pcdhgb6 RN135_MOUSE E3 ubiquitin-protein ligase RNF135 QSOX1_MOUSE Sulfhydryl oxidase 1 ATG4B_MOUSE Cysteine protease ATG4B ISOC1_MOUSE Isochorismatase domain-containing protein 1 S12A2_MOUSE Solute carrier family 12 member 2 OXLD1_MOUSE Oxidoreductase-like domain-containing protein 1 NCOA2_MOUSE Nuclear receptor coactivator 2 RT18B_MOUSE 28S ribosomal protein S18b, mitochondrial MLX_MOUSE Max-like protein X SIKE1_MOUSE Suppressor of IKBKE 1 FBX6_MOUSE F-box only protein 6 ANM3_MOUSE Protein arginine N-methyltransferase 3 TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 TEP1_MOUSE Telomerase protein component 1 TTC9C_MOUSE Tetratricopeptide repeat protein 9C NRK1_MOUSE Nicotinamide riboside kinase 1 SUSD3_MOUSE Sushi domain-containing protein 3 AFAD_MOUSE Afadin HAIR_MOUSE Lysine-specific demethylase hairless E9Q4X2_MOUSE Protein Uggt2 UCK2_MOUSE Uridine-cytidine kinase 2 LRP1B_MOUSE Low-density lipoprotein receptor-related protein 1B VAV2_MOUSE Guanine nucleotide exchange factor VAV2 PDRG1_MOUSE p53 and DNA damage-regulated protein 1 YTDC1_MOUSE YTH domain-containing protein 1 CEBPB_MOUSE CCAAT/enhancer-binding protein beta G3UYT1_MOUSE Protein Skiv2l (Fragment) UEVLD_MOUSE Ubiquitin-conjugating enzyme E2 variant 3 C19L2_MOUSE CWF19-like protein 2 KSR1_MOUSE Kinase suppressor of Ras 1 RAB43_MOUSE Ras-related protein Rab-43 TAF7_MOUSE Transcription initiation factor TFIID subunit 7 MARF1_MOUSE Meiosis arrest female protein 1 PHKG1_MOUSE Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform F6ZQA3_MOUSE Protein Numa1 (Fragment) PGAM5_MOUSE Serine/threonine-protein phosphatase PGAM5, mitochondrial
EP
Commd2 Tcirg1 Nt5m Mmp14 Med4 Bcl10 Lipt1 Cdkn1a E2f5 Smyd2 Anapc7 Las1l Sun1 Pex11b Enc1 Ccdc67 Pramel6 Aven Cetn2 Pcf11 Tbck Gm6505 Exosc8 Aspa Ubap2 Pcdhgc3 Rnf135 Qsox1 Atg4b Isoc1 Slc12a2 Oxld1 Ncoa2 Mrps18b Mlx Sike1 Fbxo6 Prmt3 Trpm8 Tep1 Ttc9c Nmrk1 Susd3 Mllt4 Hr Uggt2 Uck2 Lrp1b Vav2 Pdrg1 Ythdc1 Cebpb Skiv2l Uevld Cwf19l2 Ksr1 Rab43 Taf7 Marf1 Phkg1 Numa1 Pgam5
AC C
sp|Q8BXC6|COMD2_MOUSE tr|Q9JHF5|Q9JHF5_MOUSE sp|Q8VCE6|NT5M_MOUSE sp|P53690|MMP14_MOUSE sp|Q9CQA5|MED4_MOUSE sp|Q9Z0H7|BCL10_MOUSE sp|Q8VCM4|LIPT_MOUSE sp|P39689|CDN1A_MOUSE sp|Q61502|E2F5_MOUSE sp|Q8R5A0|SMYD2_MOUSE sp|Q9WVM3|APC7_MOUSE sp|A2BE28|LAS1L_MOUSE sp|Q9D666|SUN1_MOUSE sp|Q9Z210|PX11B_MOUSE sp|O35709|ENC1_MOUSE sp|Q7M6Y5|DEUP1_MOUSE tr|Q810Y9|Q810Y9_MOUSE sp|Q9D9K3|AVEN_MOUSE sp|Q9R1K9|CETN2_MOUSE tr|F6UFZ5|F6UFZ5_MOUSE sp|Q8BM85|TBCK_MOUSE tr|G3UW66|G3UW66_MOUSE sp|Q9D753|EXOS8_MOUSE sp|Q8R3P0|ACY2_MOUSE sp|Q91VX2|UBAP2_MOUSE tr|Q91XX1|Q91XX1_MOUSE sp|Q9CWS1|RN135_MOUSE sp|Q8BND5|QSOX1_MOUSE sp|Q8BGE6|ATG4B_MOUSE sp|Q91V64|ISOC1_MOUSE sp|P55012|S12A2_MOUSE sp|Q9CR10|OXLD1_MOUSE sp|Q61026|NCOA2_MOUSE sp|Q99N84|RT18B_MOUSE sp|O08609|MLX_MOUSE sp|Q9CPR7|SIKE1_MOUSE sp|Q9QZN4|FBX6_MOUSE sp|Q922H1|ANM3_MOUSE sp|Q8R4D5|TRPM8_MOUSE sp|P97499|TEP1_MOUSE sp|Q810A3|TTC9C_MOUSE sp|Q91W63|NRK1_MOUSE sp|Q9D176|SUSD3_MOUSE sp|Q9QZQ1|AFAD_MOUSE sp|Q61645|HAIR_MOUSE tr|E9Q4X2|E9Q4X2_MOUSE sp|Q99PM9|UCK2_MOUSE sp|Q9JI18|LRP1B_MOUSE sp|Q60992|VAV2_MOUSE sp|P59048|PDRG1_MOUSE sp|E9Q5K9|YTDC1_MOUSE sp|P28033|CEBPB_MOUSE tr|G3UYT1|G3UYT1_MOUSE sp|Q3U1V6|UEVLD_MOUSE sp|Q8BG79|C19L2_MOUSE sp|Q61097|KSR1_MOUSE sp|Q8CG50|RAB43_MOUSE sp|Q9R1C0|TAF7_MOUSE sp|Q8BJ34|MARF1_MOUSE sp|P07934|PHKG1_MOUSE tr|F6ZQA3|F6ZQA3_MOUSE sp|Q8BX10|PGAM5_MOUSE
62.472 34.2672 42.7863 50.823 26.6402 54.4164 35.6335 76.5817 22.2845 78.5528 95.3165 53.3094 59.1991 96.3764 32.6991 31.8029 22.1689 63.8159 40.1142 41.9425 58.4198 18.9069 36.1613 45.0133 18.3071 43.8795 53.3836 82.1633 26.2211 33.3612 134.619 54.3279 37.1091 60.0683 75.2647 23.5301 58.3493 35.9258 36.1727 52.9003 99.1361 46.9284 40.7454 10.3149 19.2173 49.3928 29.3414 123.314 70.1712 151.331 129.114 35.3956 30.6573 71.486 22.9039 41.5185 55.8199 44.7701 30.5984 51.4461 16.7663 27.1515
47.0653 75.2975 52.3868 55.1285 31.6803 44.5797 17.7002 19.2255 13.7108 81.9249 68.6812 65.7154 142.336 117.191 81.6121 15.4974 24.773 37.8774 19.836 29.63 65.4213 9.28917 32.785 45.9342 7.43033 20.6574 41.4543 54.5008 25.1853 27.3664 99.3332 48.7504 36.4956 16.8144 64.877 16.4825 37.2007 65.7703 30.6221 30.1058 72.5266 95.7115 34.049 30.4042 5.81756 56.7117 23.5025 149.761 68.7917 123.97 96.933 130.117 44.4964 84.1565 41.4346 93.2009 79.7286 40.7803 38.4229 15.6295 15.7913 31.2426
52.0032 50.2402 78.7344 72.1029 47.1151 81.9922 41.9101 60.722 31.7818 80.5223 91.0557 36.556 42.2513 65.2635 57.043 39.49 45.9839 113.363 65.1106 95.513 74.5159 27.5322 36.4194 66.8782 32.1283 46.8735 85.7397 72.3403 25.4616 21.1972 84.8569 114.632 81.9842 81.7094 87.7193 35.7758 41.7602 51.2611 36.6935 42.7344 77.086 135.94 62.3884 44.5814 0 38.227 28.4074 239.143 133.44 291.051 79.39 79.6948 40.8334 105.979 34.2809 111.089 41.2207 84.3553 58.3412 15.0978 23.1389 21.6815
1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.99 0.99 0.99
0.86 1.62 1.44 1.20 1.21 1.09 0.83 0.72 1.04 0.98 0.91 0.87 1.78 0.95 2.20 0.71 1.36 1.09 1.09 1.22 1.51 1.02 0.89 1.01 1.03 0.75 1.05 0.79 0.97 0.74 0.82 1.55 1.53 0.73 1.01 1.04 0.68 1.46 0.76 0.92 1.00 2.16 1.18 2.98 0.13 0.95 0.87 1.36 1.25 1.40 0.71 2.71 1.49 1.16 1.40 2.27 1.09 1.36 1.33 0.31 0.95 0.76
ACCEPTED MANUSCRIPT
M AN U
TE D
70.4807 40.0658 66.6061 139.028 28.4728 41.3594 22.0794 66.3092 42.6407 46.1592 64.9603 65.3241 40.1658 42.5928 29.8371 32.3292 39.0839 52.3927 55.7015 42.3828 45.9952 66.9751 53.8537 36.1021 117.221 41.7688 40.3449 54.8424 52.665 76.4833 37.4879 57.6632 71.3866 45.3683 45.2935 20.471 68.565 80.9823 63.7112 24.5097 8.57996 107.493 40.6417 14.2575 64.2335 50.1761 23.7707 46.3133 52.3728 89.0624 33.0436 51.8934 65.4468 159.688 26.1689 57.3798 37.5195 55.8115 57.7992 36.1507 47.8515 78.1989
77.9748 50.2753 63.4539 140.601 34.0486 41.1434 22.6042 64.973 44.8053 53.6842 75.3297 64.2056 48.9753 56.4237 18.1474 33.1695 34.2124 53.2359 41.3971 39.8383 39.3185 76.8687 56.6495 32.9852 128.103 38.9855 30.8105 54.0495 67.6023 72.36 36.1344 67.6006 53.2894 40.0822 36.0739 23.0428 76.6386 71.8617 77.7089 31.1192 12.5688 128.412 39.5035 22.0169 58.3045 47.1979 19.6073 50.0712 57.7111 85.4042 30.7244 62.049 71.7561 145.095 28.5121 62.4525 34.1989 56.8239 55.7378 39.7071 43.9058 79.779
RI PT
93.1753 48.4437 67.3264 132.037 38.2603 46.2895 20.6821 57.6891 38.7934 46.793 75.3893 64.0952 45.9663 51.2926 30.6617 33.9237 42.3159 48.9292 49.8649 36.6993 51.8027 73.3902 51.9969 35.1139 152.876 40.4782 32.7833 52.8566 64.8133 64.4245 34.0311 71.2888 66.0906 49.0914 32.267 24.8329 80.8581 61.0301 67.5914 33.6291 13.1809 118.089 34.4178 20.3368 55.9733 50.2008 20.6108 53.8526 47.82 79.2433 41.2082 71.2422 63.1517 132.859 33.7553 60.5346 32.1921 73.4203 63.0058 44.5784 48.4244 74.429
SC
FIBP_MOUSE Acidic fibroblast growth factor intracellular-binding protein 1 TAOK1_MOUSE Serine/threonine-protein kinase TAO1 1 ANM7_MOUSE Protein arginine N-methyltransferase 7 1 F195B_MOUSE Protein FAM195B 1 GPTC4_MOUSE G patch domain-containing protein 4 1 PM34_MOUSE Peroxisomal membrane protein PMP34 1 PELP1_MOUSE Proline-, glutamic acid- and leucine-rich protein 1 1 G3UWM2_MOUSE Protein Snx21 1 TOLIP_MOUSE Toll-interacting protein 1 KAD4_MOUSE Adenylate kinase 4, mitochondrial 1 CDK13_MOUSE Cyclin-dependent kinase 13 1 ABCBA_MOUSE ATP-binding cassette sub-family B member 10, mitochondrial 1 MOD5_MOUSE tRNA dimethylallyltransferase, mitochondrial 1 EGFR_MOUSE Epidermal growth factor receptor 1 INT7_MOUSE Integrator complex subunit 7 1 MB12A_MOUSE Multivesicular body subunit 12A 1 FUND1_MOUSE FUN14 domain-containing protein 1 1 RRP15_MOUSE RRP15-like protein 1 MSMO1_MOUSE Methylsterol monooxygenase 1 1 Q80ZX0_MOUSE Protein Sec24b 1 MED25_MOUSE Mediator of RNA polymerase II transcription subunit 25 1 PUS10_MOUSE Putative tRNA pseudouridine synthase Pus10 1 KPB1_MOUSE Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform 1 SNAPN_MOUSE SNARE-associated protein Snapin 1 WDR47_MOUSE WD repeat-containing protein 47 1 GPX41_MOUSE Phospholipid hydroperoxide glutathione peroxidase, mitochondrial 1 GSE1_MOUSE Genetic suppressor element 1 1 STMN1_MOUSE Stathmin 1 CNST_MOUSE Consortin 1 PPIL3_MOUSE Peptidyl-prolyl cis-trans isomerase-like 3 1 CCD43_MOUSE Coiled-coil domain-containing protein 43 1 E9QAB6_MOUSE Protein Ptar1 1 CO7A1_MOUSE Collagen alpha-1(VII) chain 1 C56D2_MOUSE Cytochrome b561 domain-containing protein 2 1 KRI1_MOUSE Protein KRI1 homolog 1 DLG2_MOUSE Disks large homolog 2 1 OSGEP_MOUSE Probable tRNA N6-adenosine threonylcarbamoyltransferase 1 MF2NB_MOUSE Protein MEF2BNB 1 TE2IP_MOUSE Telomeric repeat-binding factor 2-interacting protein 1 1 FUCO2_MOUSE Plasma alpha-L-fucosidase 1 MEP50_MOUSE Methylosome protein 50 1 DCAF7_MOUSE DDB1- and CUL4-associated factor 7 1 COA5_MOUSE Cytochrome c oxidase assembly factor 5 1 MILK1_MOUSE MICAL-like protein 1 1 UBL5_MOUSE Ubiquitin-like protein 5 1 SMRD2_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily 1 D member 2 VP37B_MOUSE Vacuolar protein sorting-associated protein 37B 1 DPH5_MOUSE Diphthine synthase 1 GBG5_MOUSE Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 1 SMCA2_MOUSE Probable global transcription activator SNF2L2 1 P2RX4_MOUSE P2X purinoceptor 4 1 TFDP1_MOUSE Transcription factor Dp-1 1 SCRIB_MOUSE Protein scribble homolog 1 PFD1_MOUSE Prefoldin subunit 1 1 Q9DAV6_MOUSE Protein Serpinb9b 1 EXOS1_MOUSE Exosome complex component CSL4 1 RWDD4_MOUSE RWD domain-containing protein 4 1 PRPK_MOUSE TP53-regulating kinase 1 RGS2_MOUSE Regulator of G-protein signaling 2 1 BTD_MOUSE Biotinidase 1 D3Z175_MOUSE MCG142459 1 TTC4_MOUSE Tetratricopeptide repeat protein 4 1
EP
Fibp Taok1 Prmt7 Fam195b Gpatch4 Slc25a17 Pelp1 Snx21 Tollip Ak4 Cdk13 Abcb10 Trit1 Egfr Ints7 Mvb12a Fundc1 Rrp15 Msmo1 Sec24b Med25 Pus10 Phka1 Snapin Wdr47 Gpx4 Gse1 Stmn1 Cnst Ppil3 Ccdc43 Ptar1 Col7a1 Cyb561d2 Kri1 Dlg2 Osgep Mef2bnb Terf2ip Fuca2 Wdr77 Dcaf7 Coa5 Micall1 Ubl5 Smarcd2 Vps37b Dph5 Gng5 Smarca2 P2rx4 Tfdp1 Scrib Pfdn1 Serpinb9b Exosc1 Rwdd4 Tp53rk Rgs2 Btd Gm5519 Ttc4
AC C
sp|Q9JI19|FIBP_MOUSE sp|Q5F2E8|TAOK1_MOUSE sp|Q922X9|ANM7_MOUSE sp|Q3UGS4|F195B_MOUSE sp|Q3TFK5|GPTC4_MOUSE sp|O70579|PM34_MOUSE sp|Q9DBD5|PELP1_MOUSE tr|G3UWM2|G3UWM2_MOUSE sp|Q9QZ06|TOLIP_MOUSE sp|Q9WUR9|KAD4_MOUSE sp|Q69ZA1|CDK13_MOUSE sp|Q9JI39|ABCBA_MOUSE sp|Q80UN9|MOD5_MOUSE sp|Q01279|EGFR_MOUSE sp|Q7TQK1|INT7_MOUSE sp|Q78HU3|MB12A_MOUSE sp|Q9DB70|FUND1_MOUSE sp|Q9CYX7|RRP15_MOUSE sp|Q9CRA4|MSMO1_MOUSE tr|Q80ZX0|Q80ZX0_MOUSE sp|Q8VCB2|MED25_MOUSE sp|Q9D3U0|PUS10_MOUSE sp|P18826|KPB1_MOUSE sp|Q9Z266|SNAPN_MOUSE sp|Q8CGF6|WDR47_MOUSE sp|O70325|GPX41_MOUSE sp|Q3U3C9|GSE1_MOUSE sp|P54227|STMN1_MOUSE sp|Q8CBC4|CNST_MOUSE sp|Q9D6L8|PPIL3_MOUSE sp|Q9CR29|CCD43_MOUSE tr|E9QAB6|E9QAB6_MOUSE sp|Q63870|CO7A1_MOUSE sp|Q9WUE3|C56D2_MOUSE sp|Q8VDQ9|KRI1_MOUSE sp|Q91XM9|DLG2_MOUSE sp|Q8BWU5|OSGEP_MOUSE sp|Q9D6Y4|MF2NB_MOUSE sp|Q91VL8|TE2IP_MOUSE sp|Q99KR8|FUCO2_MOUSE sp|Q99J09|MEP50_MOUSE sp|P61963|DCAF7_MOUSE sp|Q99M07|COA5_MOUSE sp|Q8BGT6|MILK1_MOUSE sp|Q9EPV8|UBL5_MOUSE sp|Q99JR8|SMRD2_MOUSE sp|Q8R0J7|VP37B_MOUSE sp|Q9CWQ0|DPH5_MOUSE sp|Q80SZ7|GBG5_MOUSE sp|Q6DIC0|SMCA2_MOUSE sp|Q9JJX6|P2RX4_MOUSE sp|Q08639|TFDP1_MOUSE sp|Q80U72|SCRIB_MOUSE sp|Q9CWM4|PFD1_MOUSE tr|Q9DAV6|Q9DAV6_MOUSE sp|Q9DAA6|EXOS1_MOUSE sp|Q9CPR1|RWDD4_MOUSE sp|Q99PW4|PRPK_MOUSE sp|O08849|RGS2_MOUSE sp|Q8CIF4|BTD_MOUSE tr|D3Z175|D3Z175_MOUSE sp|Q8R3H9|TTC4_MOUSE
83.9864 37.2615 68.9312 127.154 31.8534 45.35 19.5894 57.2906 35.4496 37.9219 62.9864 63.3032 35.8097 35.9726 41.3847 31.9145 45.6457 45.9792 61.7999 37.401 56.1439 60.0738 46.4939 36.3917 134.757 41.0348 40.2263 50.4353 46.095 63.9029 32.984 56.9959 79.4722 51.1367 38.8198 20.6919 67.6033 65.2168 49.0248 24.9718 8.39313 88.8059 32.7385 11.2732 57.3264 49.2909 23.0504 45.9818 38.2312 75.7343 40.2768 55.6765 51.1822 134.506 28.7191 50.0944 32.3278 66.2642 59.273 37.0647 47.6349 65.2776
80.5218 39.3014 71.0779 91.3146 22.5184 54.5799 21.2038 16.4654 35.3706 47.126 34.63 44.2371 57.2285 38.4079 44.8306 40.9392 27.7497 35.9802 21.6271 54.5702 38.0298 92.6058 22.1133 25.1036 129.369 32.752 34.8819 55.1666 48.2763 46.6505 28.8122 78.6148 52.7805 30.6266 16.6905 23.5651 63.407 45.7061 41.8134 21.5842 102.773 93.3928 19.5887 82.4311 54.4414 52.2303 19.5316 49.5135 36.3585 49.7533 27.9658 57.3478 91.4035 127.331 92.8716 72.5581 19.7586 61.1894 24.1954 9.64209 46.3376 65.7195
69.8845 46.1075 64.7974 208.84 31.7845 53.4685 32.5542 46.3926 53.3509 79.0859 61.8391 50.6309 54.9192 39.9381 42.5856 46.286 42.0183 57.3486 19.0431 41.5689 73.3447 97.0902 31.3262 58.065 136.496 68.266 119.844 53.2987 99.9865 120.466 42.5025 73.4063 70.4106 28.5119 38.9703 23.4588 51.0396 102.447 109.475 39.4648 190.001 179.584 51.0101 214.506 123.055 50.4381 33.1975 52.6623 45.9604 111.584 27.3717 93.2189 63.6845 285.096 66.9514 66.4215 63.7815 39.7173 79.0699 31.8494 61.207 157.552
0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.95 0.95 0.95
0.92 0.96 1.01 1.11 0.81 1.23 1.26 0.51 1.09 1.36 0.69 0.73 1.30 0.83 1.44 1.32 0.86 0.92 0.39 1.22 1.14 1.35 0.50 1.17 0.98 1.23 2.12 1.01 1.26 1.19 1.00 1.18 0.90 0.63 0.72 1.04 0.77 1.04 1.15 1.05 13.45 1.21 0.94 8.58 1.48 1.02 1.19 1.02 0.82 0.96 0.75 1.22 1.21 1.41 2.67 1.18 1.20 0.78 0.85 0.51 1.12 1.46
ACCEPTED MANUSCRIPT
TE D
28.2458 83.5649 45.1324 38.9236 49.0616 27.7228 38.515 95.2379 26.3498 77.7603 50.1175 87.8552 59.6281 81.4096 88.9452 42.188 64.5457 47.2917 67.5585 42.5854 31.4857 59.8641 87.2546 35.3543 34.0808 90.9161 46.2909 69.0016 12.0015 119.681 21.0017 73.0743 48.3177 30.7245 87.6258 44.0994 168.441 34.9438 86.2719 49.3331 261.402 69.6736 86.0814 32.8033 152.694 50.503 51.8211 52.931 28.0771 126.814 85.4267 43.9099 30.9198 22.707 71.214 38.7078 53.453 75.2865 43.7123 58.9384 33.1571 97.8593
33.6637 83.0315 59.8408 33.8416 62.386 26.3693 33.6567 119.995 25.5286 77.5123 61.8493 78.1151 66.3099 94.6997 77.7439 47.4857 81.2157 43.8428 72.9087 54.4761 29.84 35.6867 95.4451 36.4296 35.0716 100.758 40.118 52.2171 22.939 135.186 18.9617 70.6171 26.84 30.1302 88.6194 45.1427 124.623 42.9926 44.2321 57.3558 249.863 61.7487 81.1738 30.2338 175.115 40.4022 55.087 59.3675 32.7078 109.526 85.8984 44.3479 28.7131 20.6393 74.7454 29.9756 47.9858 63.2155 34.5942 55.0509 33.284 95.8406
RI PT
34.6892 73.4787 62.4465 34.5142 60.125 29.7541 27.7983 134.651 25.4404 81.6917 66.2699 98.4652 67.9246 91.5175 72.5904 45.5529 77.2835 37.8458 80.5714 50.9561 26.621 44.828 97.1621 30.9095 36.4791 93.9194 28.5942 50.2583 24.7494 139.18 17.4891 65.3669 29.9205 26.8938 90.809 48.8149 185.704 48.6369 65.3222 51.2664 248.303 69.2723 98.1848 34.5705 154.083 39.6502 68.9154 66.1275 36.8784 118.239 86.8312 44.4258 28.2996 5.56217 80.475 21.1897 48.2784 70.2622 52.0596 57.406 41.619 91.2239
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
MCM3_MOUSE DNA replication licensing factor MCM3 CC117_MOUSE Coiled-coil domain-containing protein 117 INGR1_MOUSE Interferon gamma receptor 1 PKHG5_MOUSE Pleckstrin homology domain-containing family G member 5 NLRX1_MOUSE NLR family member X1 FBX2_MOUSE F-box only protein 2 RBBP7_MOUSE Histone-binding protein RBBP7 PLCH1_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 EDC3_MOUSE Enhancer of mRNA-decapping protein 3 EXTL2_MOUSE Exostosin-like 2 HDGR3_MOUSE Hepatoma-derived growth factor-related protein 3 PEX16_MOUSE Peroxisomal membrane protein PEX16 S2535_MOUSE Solute carrier family 25 member 35 S4A4_MOUSE Electrogenic sodium bicarbonate cotransporter 1 CT2NL_MOUSE CTTNBP2 N-terminal-like protein CTDP1_MOUSE RNA polymerase II subunit A C-terminal domain phosphatase HTRA2_MOUSE Serine protease HTRA2, mitochondrial ZN330_MOUSE Zinc finger protein 330 MITD1_MOUSE MIT domain-containing protein 1 ANXA7_MOUSE Annexin A7 ZFYV1_MOUSE Zinc finger FYVE domain-containing protein 1 NOG2_MOUSE Nucleolar GTP-binding protein 2 HDAC6_MOUSE Histone deacetylase 6 BCL7A_MOUSE B-cell CLL/lymphoma 7 protein family member A FA50A_MOUSE Protein FAM50A CASC3_MOUSE Protein CASC3 E9Q6K3_MOUSE Protein Pibf1 EIF1A_MOUSE Probable RNA-binding protein EIF1AD NPHN_MOUSE Nephrin DUS2L_MOUSE tRNA-dihydrouridine(20) synthase [NAD(P)+]-like MAP1S_MOUSE Microtubule-associated protein 1S CGBP1_MOUSE CGG triplet repeat-binding protein 1 TIM23_MOUSE Mitochondrial import inner membrane translocase subunit Tim23 E9Q842_MOUSE Protein Nav2 NDUF5_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 WDR19_MOUSE WD repeat-containing protein 19 E0CX20_MOUSE Protein BUD31 homolog IGSF8_MOUSE Immunoglobulin superfamily member 8 RING2_MOUSE E3 ubiquitin-protein ligase RING2 B7FAU2_MOUSE Tafazzin (Fragment) Q3TIV9_MOUSE AP-1 complex subunit sigma-2 EGLN1_MOUSE Egl nine homolog 1 EDEM3_MOUSE ER degradation-enhancing alpha-mannosidase-like protein 3 XRCC4_MOUSE DNA repair protein XRCC4 AKTS1_MOUSE Proline-rich AKT1 substrate 1 N6MT2_MOUSE N(6)-adenine-specific DNA methyltransferase 2 SSBP2_MOUSE Single-stranded DNA-binding protein 2 MA7D2_MOUSE MAP7 domain-containing protein 2 CHSTC_MOUSE Carbohydrate sulfotransferase 12 TBA4A_MOUSE Tubulin alpha-4A chain LRP5_MOUSE Low-density lipoprotein receptor-related protein 5 TM10A_MOUSE tRNA methyltransferase 10 homolog A H7BWY8_MOUSE Pre-rRNA-processing protein TSR2 homolog TMOD2_MOUSE Tropomodulin-2 PPCS_MOUSE Phosphopantothenate--cysteine ligase TAB1_MOUSE TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TAF12_MOUSE Transcription initiation factor TFIID subunit 12 MIC1_MOUSE Uncharacterized protein C18orf8 homolog OGFD3_MOUSE 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 RIOK3_MOUSE Serine/threonine-protein kinase RIO3 GALK2_MOUSE N-acetylgalactosamine kinase MIER1_MOUSE Mesoderm induction early response protein 1
EP
Mcm3 Ccdc117 Ifngr1 Plekhg5 Nlrx1 Fbxo2 Rbbp7 Plch1 Edc3 Extl2 Hdgfrp3 Pex16 Slc25a35 Slc4a4 Cttnbp2nl Ctdp1 Htra2 Znf330 Mitd1 Anxa7 Zfyve1 Gnl2 Hdac6 Bcl7a Fam50a Casc3 Pibf1 Eif1ad Nphs1 Dus2 Map1s Cggbp1 Timm23 Nav2 Ndufaf5 Wdr19 Bud31 Igsf8 Rnf2 Taz Ap1s2 Egln1 Edem3 Xrcc4 Akt1s1 N6amt2 Ssbp2 Map7d2 Chst12 Tuba4a Lrp5 Trmt10a Tsr2 Tmod2 Ppcs Tab1 Taf12 Mic1 Ogfod3 Riok3 Galk2 Mier1
AC C
sp|P25206|MCM3_MOUSE sp|Q6PB51|CC117_MOUSE sp|P15261|INGR1_MOUSE sp|Q66T02|PKHG5_MOUSE sp|Q3TL44|NLRX1_MOUSE sp|Q80UW2|FBX2_MOUSE sp|Q60973|RBBP7_MOUSE sp|Q4KWH5|PLCH1_MOUSE sp|Q8K2D3|EDC3_MOUSE sp|Q9ES89|EXTL2_MOUSE sp|Q9JMG7|HDGR3_MOUSE sp|Q91XC9|PEX16_MOUSE sp|Q5SWT3|S2535_MOUSE sp|O88343|S4A4_MOUSE sp|Q99LJ0|CT2NL_MOUSE sp|Q7TSG2|CTDP1_MOUSE sp|Q9JIY5|HTRA2_MOUSE sp|Q922H9|ZN330_MOUSE sp|Q8VDV8|MITD1_MOUSE sp|Q07076|ANXA7_MOUSE sp|Q810J8|ZFYV1_MOUSE sp|Q99LH1|NOG2_MOUSE sp|Q9Z2V5|HDAC6_MOUSE sp|Q9CXE2|BCL7A_MOUSE sp|Q9WV03|FA50A_MOUSE sp|Q8K3W3|CASC3_MOUSE tr|E9Q6K3|E9Q6K3_MOUSE sp|Q3THJ3|EIF1A_MOUSE sp|Q9QZS7|NPHN_MOUSE sp|Q9D7B1|DUS2L_MOUSE sp|Q8C052|MAP1S_MOUSE sp|Q8BHG9|CGBP1_MOUSE sp|Q9WTQ8|TIM23_MOUSE tr|E9Q842|E9Q842_MOUSE sp|A2APY7|NDUF5_MOUSE sp|Q3UGF1|WDR19_MOUSE tr|E0CX20|E0CX20_MOUSE sp|Q8R366|IGSF8_MOUSE sp|Q9CQJ4|RING2_MOUSE tr|B7FAU2|B7FAU2_MOUSE tr|Q3TIV9|Q3TIV9_MOUSE sp|Q91YE3|EGLN1_MOUSE sp|Q2HXL6|EDEM3_MOUSE sp|Q924T3|XRCC4_MOUSE sp|Q9D1F4|AKTS1_MOUSE sp|Q9CY45|N6MT2_MOUSE sp|Q9CYZ8|SSBP2_MOUSE sp|A2AG50|MA7D2_MOUSE sp|Q99LL3|CHSTC_MOUSE sp|P68368|TBA4A_MOUSE sp|Q91VN0|LRP5_MOUSE sp|Q8C1Z8|TM10A_MOUSE tr|H7BWY8|H7BWY8_MOUSE sp|Q9JKK7|TMOD2_MOUSE sp|Q8VDG5|PPCS_MOUSE sp|Q8CF89|TAB1_MOUSE sp|Q8VE65|TAF12_MOUSE sp|Q8VC42|MIC1_MOUSE sp|Q9D136|OGFD3_MOUSE sp|Q9DBU3|RIOK3_MOUSE sp|Q68FH4|GALK2_MOUSE sp|Q5UAK0|MIER1_MOUSE
25.8759 65.3973 41.7868 35.4512 40.5414 27.7327 28.7297 96.1509 23.1276 72.2572 47.4478 96.7717 53.414 67.5836 73.7829 34.7688 51.5407 35.776 65.5721 32.9436 24.39 61.8027 76.2265 25.1776 30.4827 70.9171 29.364 58.3569 11.1249 104.603 16.5817 57.2119 45.2703 22.8589 75.2752 40.0288 199.965 33.6083 94.6674 34.7238 216.47 65.3157 87.267 31.2709 104.227 41.638 54.7744 48.9627 26.3716 113.252 70.6757 35.7268 24.9096 4.94894 62.3841 24.1425 43.9039 68.0235 51.7575 49.7465 34.0378 74.3223
28.4297 184.067 27.1551 23.9758 25.6658 24.019 24.3971 124.978 28.3598 76.8605 41.2322 100.219 74.4939 108.554 63.9028 44.2204 64.5394 36.2306 45.0626 36.6757 20.6941 38.6008 75.9598 24.8541 32.6623 77.1058 38.5845 35.7151 856.211 219.35 10.924 52.9175 45.8387 15.6851 58.778 71.3914 163.019 48.0477 34.8713 27.4893 147.309 73.9 58.4651 20.0733 133.246 28.2213 27.3373 21.282 12.5909 205.904 39.9922 17.264 26.189 42.4305 54.6668 49.2617 27.6793 71.7422 26.142 46.6335 52.408 76.7493
24.5418 359.401 25.1007 45.5058 32.0692 39.3588 43.752 82.6531 34.0735 105.842 75.1994 78.1455 115.437 75.6426 115.95 15.8044 91.9112 75.0401 40.2311 22.8552 31.7483 53.4417 46.5483 59.2605 36.3075 65.7532 278.176 110.651 583.077 292.544 24.7018 92.1686 49.2135 38.7927 131.561 31.9664 162.026 15.4519 67.5751 39.9626 311.11 128.059 55.1257 32.249 299.913 66.3166 58.3266 59.627 5.34237 302.482 52.2565 54.7055 40.5516 10.2427 57.1261 62.6528 55.4802 64.1111 37.2481 68.1604 39.2627 138.151
0.95 0.95 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90
0.84 3.46 0.49 0.95 0.53 1.10 1.03 0.90 1.21 1.15 1.00 0.96 1.49 1.07 1.11 0.68 1.10 1.31 0.58 0.64 0.90 0.88 0.66 1.27 0.98 0.77 4.23 1.23 39.16 1.98 0.93 1.05 1.21 0.95 1.07 1.11 0.92 0.76 0.68 0.67 0.90 1.45 0.62 0.78 1.41 1.05 0.71 0.68 0.28 2.07 0.54 0.81 1.13 1.86 0.74 1.87 0.82 0.93 0.66 0.99 1.23 1.14
ACCEPTED MANUSCRIPT
Nwc Sssca1 Inip Ermp1 Alpl Wdr33 Secisbp2 Arpc4 Kif20b Morc3 Zfp952 Arfrp1 Ahnak2 Hint2 Aasdhppt
28.3943 40.3902 49.0305 22.6096 24.933 79.8821 46.4672 45.2032 109.691 39.0358 31.5549 35.7927 31.3604 59.6274 148.277 55.9945 40.2458 45.5227 88.6529 61.2827 62.5377 65.2549 14.2157 69.4198 34.3802 82.3087 147.726 57.0475 53.2467 37.7834 101.62 25.1712 108.443 58.3888 27.6402 156.752 34.0133 74.1339 16.5885 84.9561 27.2072 44.3065 32.578 143.938 44.1262 34.714 41.1384 37.9414 36.8918 88.8528 31.0465 11.8945 65.6069 23.4382 61.8964 46.138 45.1291 18.8237 43.5918 23.1689 36.7215 67.2868
29.8562 28.1099 40.7659 21.0887 27.5126 71.651 47.4559 27.5818 100.296 24.5882 27.0103 38.0271 37.4322 47.9231 150.448 49.6606 33.0112 46.1547 78.5814 52.9665 55.8648 64.7405 14.9199 73.2468 31.4403 49.1216 141.205 50.7994 42.4128 34.8093 89.3054 27.2766 104.62 57.3476 28.2888 138.426 38.9555 51.9198 17.4047 26.9145 22.1349 36.3048 30.8923 63.1571 56.5252 33.9248 40.3045 40.3063 35.3149 78.0402 23.6278 11.2415 55.1921 20.228 49.9594 27.0297 30.9822 12.7202 37.773 18.3477 30.1231 61.9382
TE D
M AN U
SC
RI PT
OSBL1_MOUSE Oxysterol-binding protein-related protein 1 1 34.3932 PIGT_MOUSE GPI transamidase component PIG-T 1 36.2941 F122A_MOUSE Protein FAM122A 1 36.0077 RIOK1_MOUSE Serine/threonine-protein kinase RIO1 1 21.1065 AXIN1_MOUSE Axin-1 1 29.2725 KLC2_MOUSE Kinesin light chain 2 1 78.5912 NR2CA_MOUSE Nuclear receptor 2C2-associated protein 1 56.289 SMYD5_MOUSE SET and MYND domain-containing protein 5 1 51.8664 PKNX1_MOUSE Homeobox protein PKNOX1 1 99.3799 PJA1_MOUSE E3 ubiquitin-protein ligase Praja-1 1 26.8789 NRF1_MOUSE Nuclear respiratory factor 1 1 28.5578 PPCEL_MOUSE Prolyl endopeptidase-like 1 41.0977 FA86A_MOUSE Protein FAM86A 1 46.4056 RPB11_MOUSE DNA-directed RNA polymerase II subunit RPB11 1 49.1332 COG6_MOUSE Conserved oligomeric Golgi complex subunit 6 1 146.407 RNF25_MOUSE E3 ubiquitin-protein ligase RNF25 1 44.3568 PHAR4_MOUSE Phosphatase and actin regulator 4 1 29.3126 L12R1_MOUSE Loss of heterozygosity 12 chromosomal region 1 protein homolog 1 43.688 CD033_MOUSE UPF0462 protein C4orf33 homolog 1 91.0531 GPR1_MOUSE G-protein coupled receptor 1 1 46.7244 SH3B4_MOUSE SH3 domain-binding protein 4 1 59.1919 UBIP1_MOUSE Upstream-binding protein 1 1 83.4844 NANP_MOUSE N-acylneuraminate-9-phosphatase 1 23.6892 PARVB_MOUSE Beta-parvin 1 75.1877 ENOG_MOUSE Gamma-enolase 1 32.0998 SMRCD_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily 1A containing DEAD/H 71.169 box 1 CLP1_MOUSE Polyribonucleotide 5'-hydroxyl-kinase Clp1 1 148.466 S2546_MOUSE Solute carrier family 25 member 46 1 68.0015 HOP2_MOUSE Homologous-pairing protein 2 homolog 1 39.1377 TPK1_MOUSE Thiamin pyrophosphokinase 1 1 40.6005 DTBP1_MOUSE Dysbindin 1 90.4282 ATX1L_MOUSE Ataxin-1-like 1 31.2396 RL22L_MOUSE 60S ribosomal protein L22-like 1 1 123.198 FOXO1_MOUSE Forkhead box protein O1 1 62.7542 TTC33_MOUSE Tetratricopeptide repeat protein 33 1 29.1053 BL1S5_MOUSE Biogenesis of lysosome-related organelles complex 1 subunit 5 1 136.019 KLF8_MOUSE Krueppel-like factor 8 1 42.0908 MK08_MOUSE Mitogen-activated protein kinase 8 1 61.4194 SCO1_MOUSE Protein SCO1 homolog, mitochondrial 1 21.469 TSP1_MOUSE Thrombospondin-1 1 17.3691 NUD15_MOUSE Probable 8-oxo-dGTP diphosphatase NUDT15 1 28.9634 TM143_MOUSE Transmembrane protein 143 1 56.3894 MIP18_MOUSE Mitotic spindle-associated MMXD complex subunit MIP18 1 38.4376 UBP24_MOUSE Ubiquitin carboxyl-terminal hydrolase 24 1 151.26 GNAQ_MOUSE Guanine nucleotide-binding protein G(q) subunit alpha 1 59.0977 MRE11_MOUSE Double-strand break repair protein MRE11A 1 41.4043 CA050_MOUSE Uncharacterized protein C1orf50 homolog 1 39.1983 CK074_MOUSE Uncharacterized protein C11orf74 homolog 1 42.0098 SSA27_MOUSE Sjoegren syndrome/scleroderma autoantigen 1 homolog 1 39.8197 SOSSC_MOUSE SOSS complex subunit C 1 76.7808 ERMP1_MOUSE Endoplasmic reticulum metallopeptidase 1 1 23.6943 PPBT_MOUSE Alkaline phosphatase, tissue-nonspecific isozyme 1 11.9535 WDR33_MOUSE pre-mRNA 3' end processing protein WDR33 1 77.4144 Q3U1C4_MOUSE MCG1271 1 20.7131 ARPC4_MOUSE Actin-related protein 2/3 complex subunit 4 1 53.4193 KI20B_MOUSE Kinesin-like protein KIF20B 1 32.596 F7BJB9_MOUSE Protein Morc3 1 44.9157 B0V2W3_MOUSE Protein Zfp952 (Fragment) 1 19.4056 ARFRP_MOUSE ADP-ribosylation factor-related protein 1 1 36.1231 F7DBB3_MOUSE Protein Ahnak2 (Fragment) 1 16.8002 HINT2_MOUSE Histidine triad nucleotide-binding protein 2, mitochondrial 1 33.6223 ADPPT_MOUSE L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 77.9181
EP
Osbpl1a Pigt Fam122a Riok1 Axin1 Klc2 Nr2c2ap Smyd5 Pknox1 Pja1 Nrf1 Prepl Fam86a Polr2j Cog6 Rnf25 Phactr4 Loh12cr1 D3Ertd751e Gpr1 Sh3bp4 Ubp1 Nanp Parvb Eno2 Smarcad1 Clp1 Slc25a46 Psmc3ip Tpk1 Dtnbp1 Atxn1l Rpl22l1 Foxo1 Ttc33 Bloc1s5 Klf8 Mapk8 Sco1 Thbs1 Nudt15 Tmem143 Fam96b Usp24 Gnaq Mre11a
AC C
sp|Q91XL9|OSBL1_MOUSE sp|Q8BXQ2|PIGT_MOUSE sp|Q9DB52|F122A_MOUSE sp|Q922Q2|RIOK1_MOUSE sp|O35625|AXIN1_MOUSE sp|O88448|KLC2_MOUSE sp|Q3TV70|NR2CA_MOUSE sp|Q3TYX3|SMYD5_MOUSE sp|O70477|PKNX1_MOUSE sp|O55176|PJA1_MOUSE sp|Q9WU00|NRF1_MOUSE sp|Q8C167|PPCEL_MOUSE sp|Q3UZW7|FA86A_MOUSE sp|O08740|RPB11_MOUSE sp|Q8R3I3|COG6_MOUSE sp|Q9QZR0|RNF25_MOUSE sp|Q501J7|PHAR4_MOUSE sp|Q9D920|L12R1_MOUSE sp|Q8BGN2|CD033_MOUSE sp|Q8K087|GPR1_MOUSE sp|Q921I6|SH3B4_MOUSE sp|Q811S7|UBIP1_MOUSE sp|Q9CPT3|NANP_MOUSE sp|Q9ES46|PARVB_MOUSE sp|P17183|ENOG_MOUSE sp|Q04692|SMRCD_MOUSE sp|Q99LI9|CLP1_MOUSE sp|Q9CQS4|S2546_MOUSE sp|O35047|HOP2_MOUSE sp|Q9R0M5|TPK1_MOUSE sp|Q91WZ8|DTBP1_MOUSE sp|P0C7T6|ATX1L_MOUSE sp|Q9D7S7|RL22L_MOUSE sp|Q9R1E0|FOXO1_MOUSE sp|Q9D6K7|TTC33_MOUSE sp|Q8R015|BL1S5_MOUSE sp|Q8BLM0|KLF8_MOUSE sp|Q91Y86|MK08_MOUSE sp|Q5SUC9|SCO1_MOUSE sp|P35441|TSP1_MOUSE sp|Q8BG93|NUD15_MOUSE sp|Q8VD26|TM143_MOUSE sp|Q9D187|MIP18_MOUSE sp|B1AY13|UBP24_MOUSE sp|P21279|GNAQ_MOUSE sp|Q61216|MRE11_MOUSE sp|Q5EBG8|CA050_MOUSE sp|Q9CQI4|CK074_MOUSE sp|P56873|SSA27_MOUSE sp|Q3TXT3|SOSSC_MOUSE sp|Q3UVK0|ERMP1_MOUSE sp|P09242|PPBT_MOUSE sp|Q8K4P0|WDR33_MOUSE tr|Q3U1C4|Q3U1C4_MOUSE sp|P59999|ARPC4_MOUSE sp|Q80WE4|KI20B_MOUSE tr|F7BJB9|F7BJB9_MOUSE tr|B0V2W3|B0V2W3_MOUSE sp|Q8BXL7|ARFRP_MOUSE tr|F7DBB3|F7DBB3_MOUSE sp|Q9D0S9|HINT2_MOUSE sp|Q9CQF6|ADPPT_MOUSE
26.5958 40.8352 35.6473 18.1835 21.1176 70.4377 44.5089 59.2406 86.4567 34.2399 26.6084 30.3451 31.687 48.7103 111.164 39.3892 28.6248 32.8799 80.6205 42.6973 51.8665 66.7897 18.5673 54.3832 27.1722 86.089 119.512 59.1085 38.5705 33.89 79.0018 22.0877 98.0727 48.6424 21.3468 117.21 27.3742 66.213 15.7421 62.2013 26.7003 51.0539 30.7115 192.727 32.9314 32.0096 29.2767 28.892 30.9268 64.9621 23.5967 9.32828 68.0593 17.8011 49.1826 40.5743 46.2794 20.0802 30.585 15.8826 30.0596 62.2743
23.8626 46.8293 32.3086 20.9284 14.3586 110.119 41.369 40.3232 76.3929 8.29677 20.7753 32.3871 37.9185 44.3141 160.881 30.3555 34.1263 34.9248 56.3935 25.4163 54.6596 49.7402 28.2431 86.3699 71.795 69.3473 111.834 34.4275 25.5113 24.4871 55.7464 15.0686 78.7329 36.5938 12.8395 79.5846 37.0805 74.84 10.9157 61.2229 21.6926 29.3832 65.4068 164.6 66.5142 42.3312 21.7702 29.5018 9.02406 57.7589 28.2628 115.932 71.5911 12.3281 57.5419 0.54281 48.4563 21.2912 45.653 7.51846 8.93695 56.7668
41.2389 46.7529 63.2453 23.319 34.9183 134.648 69.1365 52.5795 132.921 16.612 21.4 38.9585 50.2452 104.368 114.828 58.1484 16.0476 65.8107 114.29 49.7546 47.6404 41.083 48.8224 84.6714 37.6809 72.8148 163.378 49.2452 48.6614 41.8832 105.863 53.5901 118.478 75.6775 24.6023 154.093 33.0017 64.5883 15.7318 38.0897 39.8106 40.546 97.9686 175.752 38.3524 61.0336 61.6304 62.8893 11.8505 135.745 26.3328 148.555 102.551 42.269 48.7996 74.1876 39.4262 28.3798 43.2368 14.2543 45.6543 66.4989
0.90 0.90 0.90 0.90 0.90 0.90 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86
1.04 1.22 1.12 1.01 0.91 1.54 1.08 0.96 1.00 0.38 0.70 0.93 1.13 1.37 0.94 0.88 0.72 1.13 0.95 0.70 0.84 0.61 2.03 1.18 1.65 0.93 0.93 0.67 0.80 0.85 0.84 1.22 0.85 0.93 0.66 0.80 0.92 1.03 0.70 0.97 1.09 0.69 2.30 1.15 1.02 1.36 1.04 1.16 0.27 1.17 1.00 11.09 1.22 1.24 0.92 0.95 0.98 1.30 1.12 0.54 0.78 0.85
ACCEPTED MANUSCRIPT
24.1739 66.3887 45.2548 29.1952 48.0297 44.2015 39.4355 37.0645 34.7513 27.9428 59.9889 40.4069 74.8821 38.7746 25.4898 44.6463 58.7551 44.0046 116.374 20.773 45.9975 55.3638 39.9464 54.4471 82.9932 60.3619 53.1544 33.5923 103.542 50.1291 50.7717 41.479 88.8025 59.8976 90.5729 79.0008 91.0282 60.2452 34.0666 37.9988 93.3637 30.9994 87.5462 96.1073 42.8512 31.1304 51.7453 88.9689 70.1443 40.4944 66.3206 41.9918 42.976 31.1957 54.1784 37.0793 30.8321 85.0363 177.866 83.3912 58.7298 76.2407
28.601 57.091 45.9637 31.6886 45.0813 42.451 36.0651 28.9261 28.7573 25.0085 67.2626 35.2168 73.0927 34.5444 28.1152 47.1312 58.0709 45.3412 100.883 15.2402 43.9762 35.8363 35.1694 59.8653 59.6719 57.3866 47.6836 20.3318 63.9904 49.3207 42.4621 35.3092 73.1096 43.0345 86.1125 65.6395 73.8835 40.8132 24.1861 32.7151 74.4848 26.4829 62.7111 66.3432 34.9179 23.4413 42.1449 66.0962 50.9967 34.155 47.4362 33.2868 40.7189 19.2675 48.3311 31.5239 28.8387 109.997 135.254 71.5691 13.8981 63.0691
RI PT
35.2322 57.496 62.9438 36.031 63.0197 50.8495 43.5885 26.9003 28.6738 26.7299 88.1064 36.5922 86.4118 41.1713 29.8486 61.3495 66.0628 53.774 148.63 20.056 48.848 44.6088 38.1162 77.2923 72.112 70.6513 55.4033 19.2188 92.0842 63.5179 54.2862 41.4277 83.7225 50.1542 94.0857 91.7353 84.0732 63.2459 25.9886 33.6819 97.9187 24.8417 106.223 111.443 36.2112 24.1879 62.7901 86.0707 71.5066 42.9686 55.811 38.0042 42.7991 35.5332 76.3885 41.8972 37.2011 145.943 165.031 73.9367 32.9958 76.6037
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
Amotl1 Kdm3b Slc26a2 Pdcd2 Araf L3hypdh Pddc1 Spryd7 Polr2k Itpkc Metap1 Rbpj Hnrnpk Slc7a5 Desi2 Isca2 Lyrm9 Lrrc15 Wdr45 Tmem97 Prr14 Tns3 Pepd Coro7 Arl2bp Mgme1 Git2 Pbld2 Rlf Dhx38 Gmpr2 Khk Ptgfrn Cntln Ccdc110 Evl Ptma Crocc
TE D
Tead4 Ppig Gipc1 R3hdm2 Irak1 Radil Pnkd Fam185a Slc2a8 Poldip2 Phyh Bpgm Leprel4 Enpp3 Iws1 Oaf Arhgap18
NGRN_MOUSE Neugrin TF7L1_MOUSE Transcription factor 7-like 1 ANS1A_MOUSE Ankyrin repeat and SAM domain-containing protein 1A MICU2_MOUSE Calcium uptake protein 2, mitochondrial LTOR2_MOUSE Ragulator complex protein LAMTOR2 CU059_MOUSE UPF0769 protein C21orf59 homolog TEAD4_MOUSE Transcriptional enhancer factor TEF-3 PPIG_MOUSE Peptidyl-prolyl cis-trans isomerase G GIPC1_MOUSE PDZ domain-containing protein GIPC1 R3HD2_MOUSE R3H domain-containing protein 2 IRAK1_MOUSE Interleukin-1 receptor-associated kinase 1 RADIL_MOUSE Ras-associating and dilute domain-containing protein PNKD_MOUSE Probable hydrolase PNKD F185A_MOUSE Protein FAM185A GTR8_MOUSE Solute carrier family 2, facilitated glucose transporter member 8 PDIP2_MOUSE Polymerase delta-interacting protein 2 PAHX_MOUSE Phytanoyl-CoA dioxygenase, peroxisomal PMGE_MOUSE Bisphosphoglycerate mutase SC65_MOUSE Synaptonemal complex protein SC65 ENPP3_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 IWS1_MOUSE Protein IWS1 homolog OAF_MOUSE Out at first protein homolog RHG18_MOUSE Rho GTPase-activating protein 18 CX056_MOUSE UPF0428 protein CXorf56 homolog AMOL1_MOUSE Angiomotin-like protein 1 KDM3B_MOUSE Lysine-specific demethylase 3B S26A2_MOUSE Sulfate transporter PDCD2_MOUSE Programmed cell death protein 2 ARAF_MOUSE Serine/threonine-protein kinase A-Raf T3HPD_MOUSE Trans-L-3-hydroxyproline dehydratase PDDC1_MOUSE Parkinson disease 7 domain-containing protein 1 SPRY7_MOUSE SPRY domain-containing protein 7 RPAB4_MOUSE DNA-directed RNA polymerases I, II, and III subunit RPABC4 IP3KC_MOUSE Inositol-trisphosphate 3-kinase C MAP11_MOUSE Methionine aminopeptidase 1 SUH_MOUSE Recombining binding protein suppressor of hairless HNRPK_MOUSE Isoform 3 of Heterogeneous nuclear ribonucleoprotein K LAT1_MOUSE Large neutral amino acids transporter small subunit 1 DESI2_MOUSE Desumoylating isopeptidase 2 ISCA2_MOUSE Iron-sulfur cluster assembly 2 homolog, mitochondrial LYRM9_MOUSE LYR motif-containing protein 9 LRC15_MOUSE Leucine-rich repeat-containing protein 15 WIPI4_MOUSE WD repeat domain phosphoinositide-interacting protein 4 TMM97_MOUSE Transmembrane protein 97 PRR14_MOUSE Proline-rich protein 14 TENS3_MOUSE Tensin-3 PEPD_MOUSE Xaa-Pro dipeptidase CORO7_MOUSE Coronin-7 AR2BP_MOUSE ADP-ribosylation factor-like protein 2-binding protein MGME1_MOUSE Mitochondrial genome maintenance exonuclease 1 GIT2_MOUSE ARF GTPase-activating protein GIT2 PBLD2_MOUSE Phenazine biosynthesis-like domain-containing protein 2 A2A7F4_MOUSE Insulin-like 3 Q80X98_MOUSE DEAH (Asp-Glu-Ala-His) box polypeptide 38 GMPR2_MOUSE GMP reductase 2 KHK_MOUSE Ketohexokinase FPRP_MOUSE Prostaglandin F2 receptor negative regulator CNTLN_MOUSE Centlein CC110_MOUSE Coiled-coil domain-containing protein 110 EVL_MOUSE Ena/VASP-like protein PTMA_MOUSE Prothymosin alpha CROCC_MOUSE Rootletin
EP
Ngrn Tcf7l1 Anks1a Micu2 Lamtor2
AC C
sp|Q99KS2|NGRN_MOUSE sp|Q9Z1J1|TF7L1_MOUSE sp|P59672|ANS1A_MOUSE sp|Q8CD10|MICU2_MOUSE sp|Q9JHS3|LTOR2_MOUSE sp|Q8BL95|CU059_MOUSE sp|Q62296|TEAD4_MOUSE sp|A2AR02|PPIG_MOUSE sp|Q9Z0G0|GIPC1_MOUSE sp|Q80TM6|R3HD2_MOUSE sp|Q62406|IRAK1_MOUSE sp|Q69Z89|RADIL_MOUSE sp|Q69ZP3|PNKD_MOUSE sp|Q7TPD2|F185A_MOUSE sp|Q9JIF3|GTR8_MOUSE sp|Q91VA6|PDIP2_MOUSE sp|O35386|PAHX_MOUSE sp|P15327|PMGE_MOUSE sp|Q8K2B0|SC65_MOUSE sp|Q6DYE8|ENPP3_MOUSE sp|Q8C1D8|IWS1_MOUSE sp|Q8QZR4|OAF_MOUSE sp|Q8K0Q5|RHG18_MOUSE sp|Q8VDP2|CX056_MOUSE sp|Q9D4H4|AMOL1_MOUSE sp|Q6ZPY7|KDM3B_MOUSE sp|Q62273|S26A2_MOUSE sp|P46718|PDCD2_MOUSE sp|P04627|ARAF_MOUSE sp|Q9CXA2|T3HPD_MOUSE sp|Q8BFQ8|PDDC1_MOUSE sp|Q3TFQ1|SPRY7_MOUSE sp|Q63871|RPAB4_MOUSE sp|Q7TS72|IP3KC_MOUSE sp|Q8BP48|MAP11_MOUSE sp|P31266|SUH_MOUSE sp|P61979-3|HNRPK_MOUSE sp|Q9Z127|LAT1_MOUSE sp|Q9D291|DESI2_MOUSE sp|Q9DCB8|ISCA2_MOUSE sp|Q3UN90|LYRM9_MOUSE sp|Q80X72|LRC15_MOUSE sp|Q91VM3|WIPI4_MOUSE sp|Q8VD00|TMM97_MOUSE sp|Q7TPN9|PRR14_MOUSE sp|Q5SSZ5|TENS3_MOUSE sp|Q11136|PEPD_MOUSE sp|Q9D2V7|CORO7_MOUSE sp|Q9D385|AR2BP_MOUSE sp|Q9CXC3|MGME1_MOUSE sp|Q9JLQ2|GIT2_MOUSE sp|Q9CXN7|PBLD2_MOUSE tr|A2A7F4|A2A7F4_MOUSE tr|Q80X98|Q80X98_MOUSE sp|Q99L27|GMPR2_MOUSE sp|P97328|KHK_MOUSE sp|Q9WV91|FPRP_MOUSE sp|A2AM05|CNTLN_MOUSE sp|Q3V125|CC110_MOUSE sp|P70429|EVL_MOUSE sp|P26350|PTMA_MOUSE sp|Q8CJ40|CROCC_MOUSE
22.198 47.961 45.6652 23.4969 48.8195 37.8774 34.0801 25.045 24.7447 21.0357 57.413 29.5729 62.4665 32.5436 18.2861 41.5623 46.3319 36.3367 120.012 18.7392 34.9029 47.2026 29.567 49.2898 68.8022 51.1266 42.1167 23.3188 97.476 44.4128 44.1413 32.9454 68.7287 47.3948 65.3427 72.724 67.5899 58.4187 23.7722 24.4052 77.9154 17.958 91.2875 98.4249 27.4886 20.1763 48.0116 70.7852 59.4777 30.7782 47.4979 28.5171 25.5352 32.2721 52.413 29.3362 23.5339 67.544 124.457 47.5096 54.6757 50.4878
8.78512 40.3685 71.6379 36.3849 48.631 26.649 36.8915 34.3081 19.9061 12.3758 24.1358 24.582 25.1297 38.202 22.3155 22.6499 67.1228 59.894 64.5052 25.8798 23.8859 35.4161 18.619 19.1147 59.4911 49.3057 78.8716 14.4118 73.297 58.6409 52.0889 46.1894 77.6762 47.2857 47.4577 112.149 51.9116 71.783 22.4527 22.7135 44.7368 15.3183 79.5763 131.035 18.3982 27.0098 23.9681 74.96 42.8594 19.1999 71.3152 24.6548 2.29653 19.2708 38.0818 25.585 6.85977 64.0468 151.712 79.7548 42.8917 43.6676
31.8623 69.2689 94.3957 30.9643 55.7144 53.1197 45.7188 73.1394 26.3683 52.3794 52.8742 93.3608 29.4061 79.4988 21.1381 49.5441 115.003 62.8099 54.8625 41.8267 65.7317 67.6213 40.7754 22.4484 107.147 54.9974 39.2892 50.2075 98.6743 71.4903 90.2822 37.0628 125.855 73.6365 83.7302 82.3582 79.0518 98.684 48.2955 49.3822 137.714 30.3403 90.5484 105.152 35.3554 39.7489 11.0727 137.435 70.2633 36.6144 125.759 39.6725 0 25.0211 39.6927 30.6239 6.45414 186.078 201.988 151.965 165.541 47.1333
0.86 0.85 0.85 0.85 0.85 0.85 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.82 0.82 0.82 0.82 0.82 0.82 0.81 0.81 0.80 0.80 0.80 0.80 0.80 0.79 0.79 0.79 0.79 0.79 0.78 0.78 0.78 0.78 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.76 0.76 0.75 0.74
0.68 0.88 1.53 1.03 0.94 0.84 1.00 1.68 0.73 1.18 0.52 1.53 0.34 1.47 0.79 0.68 1.46 1.25 0.45 1.66 0.94 1.03 0.76 0.32 1.07 0.80 1.09 1.22 0.88 1.15 1.36 1.00 1.18 1.10 0.71 1.14 0.75 1.38 1.18 1.01 0.95 0.82 0.88 1.14 0.68 1.21 0.31 1.21 0.80 0.67 1.61 0.80 0.03 0.66 0.60 0.71 0.20 1.08 1.03 1.47 2.27 0.59
ACCEPTED MANUSCRIPT
34.1451 38.4605 94.8703 20.0581 28.1914 83.4278 49.2976 69.0127 47.7595 76.9776 58.7744 31.169 59.7715 49.4745 47.6121 35.749 80.7797 97.8933 31.7437 31.7479 58.003 23.5752 106.422 49.7238 58.5754 125.974 31.3573 82.9415 55.9483 56.4638 40.2402 50.8556 76.3887 93.9276 129.252 60.791 84.3456 380.501 44.8067 35.0464 30.36 94.8007 8.68772 159.838 38.7846 102.9 108.542 61.7414 118.026
27.0077 29.0346 75.7088 11.1139 23.0755 52.6985 36.9055 65.5389 24.0393 53.2193 44.4731 16.0353 45.4457 38.172 34.9516 26.6408 55.681 41.6935 24.2951 16.4572 30.7712 20.1793 34.5647 36.2238 35.1146 99.9815 16.1983 48.621 26.325 21.1899 34.9131 38.0893 46.4727 72.1874 128.261 50.9254 39.9917 312.747 30.46 12.9654 16.3036 38.4799 4.37358 58.9188 17.4026 21.6116 34.4264 31.5973 10.408
RI PT
41.6809 53.6689 88.284 12.3219 29.1247 73.9614 49.8523 82.6769 35.0924 64.3495 50.1508 17.7834 63.1644 54.9119 41.7406 31.5425 82.489 112.465 36.1502 20.086 56.8222 28.113 35.8465 52.4644 64.9009 120.802 12.4014 61.5631 36.1229 22.2641 57.6037 57.446 122.09 120.372 216.392 69.1814 57.2133 510.307 79.2979 30.8391 23.8593 34.2104 5.51561 10.681 20.9768 204.731 7.08481 94.0357 28.7547
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
TE D
BCCIP_MOUSE BRCA2 and CDKN1A-interacting protein DGUOK_MOUSE Deoxyguanosine kinase, mitochondrial SNX7_MOUSE Sorting nexin-7 SRBP2_MOUSE Sterol regulatory element-binding protein 2 PTPRM_MOUSE Receptor-type tyrosine-protein phosphatase mu PPOX_MOUSE Protoporphyrinogen oxidase PHOCN_MOUSE MOB-like protein phocein MET10_MOUSE Methyltransferase-like protein 10 SET_MOUSE Isoform 2 of Protein SET B7ZNC5_MOUSE Protein Srsf11 NC2B_MOUSE Protein Dr1 Q9D1M1_MOUSE DNA-directed RNA polymerases I and III subunit RPAC2 PALD_MOUSE Paladin HYI_MOUSE Putative hydroxypyruvate isomerase BAG2_MOUSE BAG family molecular chaperone regulator 2 RN115_MOUSE E3 ubiquitin-protein ligase RNF115 NAPSA_MOUSE Napsin-A ATP6_MOUSE ATP synthase subunit a NAAA_MOUSE N-acylethanolamine-hydrolyzing acid amidase P5CR1_MOUSE Pyrroline-5-carboxylate reductase 1, mitochondrial IFT25_MOUSE Intraflagellar transport protein 25 homolog CBPD_MOUSE Carboxypeptidase D F110C_MOUSE Protein FAM110C PHYD1_MOUSE Phytanoyl-CoA dioxygenase domain-containing protein 1 EZH1_MOUSE Histone-lysine N-methyltransferase EZH1 GPR64_MOUSE G-protein coupled receptor 64 FAKD2_MOUSE FAST kinase domain-containing protein 2 RIPL2_MOUSE RILP-like protein 2 D3Z2Y6_MOUSE Protein S100a16 (Fragment) PRG4_MOUSE Proteoglycan 4 SNTA1_MOUSE Alpha-1-syntrophin TGM2_MOUSE Protein-glutamine gamma-glutamyltransferase 2 TM109_MOUSE Transmembrane protein 109 NEUR1_MOUSE Sialidase-1 E9Q2T3_MOUSE Protein Tnxb DHYS_MOUSE Deoxyhypusine synthase U119A_MOUSE Protein unc-119 homolog A AATF_MOUSE Protein AATF PEF1_MOUSE Peflin SETD7_MOUSE Histone-lysine N-methyltransferase SETD7 DNS2A_MOUSE Deoxyribonuclease-2-alpha B7ZC50_MOUSE Heat shock protein HSP 90-alpha (Fragment) AGTRA_MOUSE Type-1A angiotensin II receptor MT2_MOUSE Metallothionein-2 RL40_MOUSE Ubiquitin-60S ribosomal protein L40 FITM2_MOUSE Fat storage-inducing transmembrane protein 2 TYB4_MOUSE Thymosin beta-4 E9PV38_MOUSE Protein Ces2g D3YYI5_MOUSE Glyceraldehyde-3-phosphate dehydrogenase
EP
Bccip Dguok Snx7 Srebf2 Ptprm Ppox Mob4 Mettl10 Set Srsf11 Dr1 Polr1d Pald1 Hyi Bag2 Rnf115 Napsa Mtatp6 Naaa Pycr1 Hspb11 Cpd Fam110c Phyhd1 Ezh1 Gpr64 Fastkd2 Rilpl2 S100a16 Prg4 Snta1 Tgm2 Tmem109 Neu1 Tnxb Dhps Unc119 Aatf Pef1 Setd7 Dnase2 Hsp90aa1 Agtr1a Mt2 Uba52 Fitm2 Tmsb4x Ces2g Gm7293
AC C
sp|Q9CWI3|BCCIP_MOUSE sp|Q9QX60|DGUOK_MOUSE sp|Q9CY18|SNX7_MOUSE sp|Q3U1N2|SRBP2_MOUSE sp|P28828|PTPRM_MOUSE sp|P51175|PPOX_MOUSE sp|Q6PEB6|PHOCN_MOUSE sp|Q9D853|MET10_MOUSE sp|Q9EQU5-2|SET_MOUSE tr|B7ZNC5|B7ZNC5_MOUSE sp|Q91WV0|NC2B_MOUSE tr|Q9D1M1|Q9D1M1_MOUSE sp|P70261|PALD_MOUSE sp|Q8R1F5|HYI_MOUSE sp|Q91YN9|BAG2_MOUSE sp|Q9D0C1|RN115_MOUSE sp|O09043|NAPSA_MOUSE sp|P00848|ATP6_MOUSE sp|Q9D7V9|NAAA_MOUSE sp|Q922W5|P5CR1_MOUSE sp|Q9D6H2|IFT25_MOUSE sp|O89001|CBPD_MOUSE sp|Q8VE94|F110C_MOUSE sp|Q9DB26|PHYD1_MOUSE sp|P70351|EZH1_MOUSE sp|Q8CJ12|GPR64_MOUSE sp|Q922E6|FAKD2_MOUSE sp|Q99LE1|RIPL2_MOUSE tr|D3Z2Y6|D3Z2Y6_MOUSE sp|Q9JM99|PRG4_MOUSE sp|Q61234|SNTA1_MOUSE sp|P21981|TGM2_MOUSE sp|Q3UBX0|TM109_MOUSE sp|O35657|NEUR1_MOUSE tr|E9Q2T3|E9Q2T3_MOUSE sp|Q3TXU5|DHYS_MOUSE sp|Q9Z2R6|U119A_MOUSE sp|Q9JKX4|AATF_MOUSE sp|Q8BFY6|PEF1_MOUSE sp|Q8VHL1|SETD7_MOUSE sp|P56542|DNS2A_MOUSE tr|B7ZC50|B7ZC50_MOUSE sp|P29754|AGTRA_MOUSE sp|P02798|MT2_MOUSE sp|P62984|RL40_MOUSE sp|P59266|FITM2_MOUSE sp|P20065|TYB4_MOUSE tr|E9PV38|E9PV38_MOUSE tr|D3YYI5|D3YYI5_MOUSE
29.2976 39.2732 59.8895 12.8149 19.1547 62.8772 35.827 45.5732 36.2668 49.4776 34.5801 19.4509 42.6885 36.3142 28.3609 20.8135 59.3049 103.356 22.3972 19.1745 47.9961 14.9123 61.1874 32.5206 47.6908 65.0275 12.9792 47.5875 34.0603 30.3079 28.897 32.0921 79.8581 63.1769 83.082 27.6924 45.2886 221.874 41.541 24.5819 14.3606 34.0668 2.93777 28.5291 11.993 127.366 13.1814 21.1937 12.6712
50.9993 52.1758 97.0824 22.2439 13.7431 35.4436 41.754 53.2633 54.0554 63.3835 28.9204 7.20857 76.9547 26.7055 34.2337 21.8831 17.1414 30.6481 21.8917 56.4924 36.0322 35.423 13.0498 8.97347 86.5259 51.5452 21.8089 33.4056 13.0151 134.151 27.8472 58.3705 23.5069 39.3905 43.7698 61.5921 47.2436 307.696 44.7814 28.9586 12.8532 103.065 426.705 88.6618 79.4337 104.725 10.4515 54.7851 17.0378
63.4091 68.8948 103.421 45.9607 7.6949 75.9842 47.8046 55.426 87.8281 128.115 47.4745 28.5829 46.246 48.2415 64.5138 83.8848 14.5893 75.0667 18.2836 75.476 37.5562 15.1044 129.409 22.3534 111.805 160.168 24.789 109.616 63.1939 194.208 39.2778 68.7578 32.7167 41.1302 45.844 77.0314 115.866 145.907 60.91 55.6387 20.919 135.561 422.979 64.7438 139.258 128.321 30.8154 25.6569 20.5979
0.74 0.74 0.74 0.74 0.74 0.73 0.73 0.73 0.73 0.73 0.73 0.72 0.72 0.71 0.71 0.71 0.70 0.69 0.69 0.69 0.69 0.68 0.67 0.67 0.67 0.67 0.67 0.67 0.66 0.65 0.65 0.65 0.64 0.63 0.61 0.60 0.60 0.60 0.58 0.57 0.57 0.56 0.51 0.51 0.49 0.48 0.41 0.34 0.16
1.51 1.31 1.09 2.11 0.37 0.71 0.90 0.72 1.71 1.36 0.70 0.73 1.00 0.72 1.11 1.57 0.19 0.50 0.59 2.55 0.64 0.98 1.00 0.31 1.61 0.86 1.06 0.99 0.83 4.17 0.69 1.17 0.28 0.38 0.26 1.07 1.15 0.51 0.85 1.28 0.62 1.85 59.82 0.90 3.66 0.76 0.36 0.52 0.26
ACCEPTED MANUSCRIPT
Table S2. Selected proteins from a TMT proteomic analysis of epididymal adipose tissue from WT and adiporedoxin null mice
AC C
EP
TE D
M AN U
Adipokines A2m Alpha-2-macroglobulin Adipoq Adiponectin Apoa1 Apolipoprotein A-I Dpp4 Dipeptidyl peptidase 4 Igfbp4 Insulin-like growth factor-binding protein 4 Lgmn Legumain Orm1 Alpha-1-acid glycoprotein 1 Retn Resistin Collagens Col1a1 Collagen alpha-1(I) chain Col1a2 Collagen alpha-2(I) chain Col3a1 Collagen alpha-1(III) chain Col4a1 Collagen alpha-1(IV) chain Col4a2 Collagen alpha-2(IV) chain Col5a1 Collagen alpha-1(V) chain Col5a2 Collagen alpha-2(V) chain Col6a1 Collagen alpha-1(VI) chain Col6a2 Collagen alpha-2(VI) chain Col6a3 Collagen alpha-6(VI) chain Col6a5 Collagen alpha-5(VI) chain Col6a6 Collagen alpha-6(VI) chain Col12a1 Isoform 2 of Collagen alpha-1(XII) chain Col14a1 Collagen, type XIV, alpha 1 Col15a1 Collagen alpha-1(XV) chain Col18a1 Collagen alpha-18 chain ER Thioredoxin fold proteins FAM213a Adiporedoxin Ero1l ERO1-like protein alpha Erp29 Endoplasmic reticulum resident protein 29 Erp44 Endoplasmic reticulum resident protein 44 P4hb/PDIA1 Protein disulfide-isomerase Pdia3/Erp57 Protein disulfide-isomerase A3 Pdia4/Erp72 Protein disulfide-isomerase A4 Pdia5 Protein disulfide-isomerase A5 Pdia6 Protein disulfide-isomerase A6 Prdx4 Peroxiredoxin-4 Tmx1 Thioredoxin-related transmembrane protein 1 Tmx2 Thioredoxin-related transmembrane protein 2 Tmx3 Protein disulfide-isomerase TMX3
Peptides #
KO/WT
128 21 114 12 2 6 12 19
1.21 1.22 1.22 1.21 1.27 1.17 1.05 1.13
57 32 15 6 15 10 16 135 85 315 146 22 18 74 58 18
0.52 0.59 0.76 0.67 0.60 0.75 0.74 0.64 0.63 0.67 0.61 0.71 0.65 0.66 0.91 0.77
19 16 28 17 113 109 81 6 39 13 7 6 7
0.06 1.05 1.06 0.98 1.00 0.98 1.05 1.06 1.03 1.07 0.92 0.82 1.00
RI PT
Description
SC
Gene Symbol
ACCEPTED MANUSCRIPT
Adrx
A.
Adiponectin
B.
3 2 1
5
SV F B ra i C n ol on H ea Sm rt In t Li ve r Lu M ng us cl e
SC A T FC
M AN U
SV F B ra i C n ol on H ea Sm rt In t Li ve r Lu M ng us cl e
FC
0
A T
0
10
RI PT
Relative expression
Relative expression
4
C.
AC C
EP
TE D
D.
Figure S1 related to Figure 6 Adrx expression in human adipocytes parallels that in mouse fat cells and affects adiponectin secretion. The mRNA distribution of Adrx A. and adiponectin B. in abdominal subcutaneous adipose tissue (AT), and isolated fat cells (FC) and stromal-vascular fractions (SVF) obtained after collagenase digestion is shown in comparison to the other tissues lindicated (n=3). C. Adrx mRNA and protein shows a marked increase in expression during the differentiation of human preadipocytes. The data are expressed as % of one of the 4 cultures that was set to an arbitrary value of 1. D. (I.-IV.) shows that knockdown of Adrx mRNA and protein did not decrease adiponectin mRNA, but markedly decreased the secretion of (HMW) and lower molecular weight forms (MMW and LMW) into the medium. The data in all panels are representative of 3 or more independent experiments. The data in panel D were reproduced in cells from 2 individuals.
ACCEPTED MANUSCRIPT
A
600 500
(%)
400 300
100 0 P58IPK
400
HERP
EDEM1
KO
EP
TE D
(%)
200
0
WARS
WT
300
100
EDEM1
M AN U
CHOP
SC
200
B
KO
RI PT
WT
AC C
F4/80
TNFa
CD11b
Figure S2 related to Figure 5 mRNA Expression of adipocyte ER stress and inflammation markers in the Adrx null and wild type mice. A. ER stress markers (HERP: homocysteine-induced ER protein; CHOP: CAAT/enhancer binding protein (C/EBP) homologous protein; EDEM1: ER degradation enhancer, mannosidase alphalike 1; WARS: tryptophanyl tRNA synthetase; P58IPK: p58 inhibitor of interferon-induced double-stranded RNA-activated protein kinase) and B. Inflammatory markers were measured by RT-qPCR from 8-week old adrx null and wild types mice adipose tissue.
ACCEPTED MANUSCRIPT
B
C Lean (%)
Fat (%)
70.0
50 45
45.0 40.0
60.0
40
35.0
50.0
30.0
40.0
%
%
30
25
20.0
30.0
15
15.0
SC
20
20.0
10.0
10
10.0
5 0 8
10
12
14 16 Week(s)
18
20
22
5.0
0.0
24
0.0
KO
D
E 2
Fasting Glucose
120
Fasting Insulin
TE D
1.5
WT
M AN U
6
ng/ml
100 80 60
40
1
0.5
20 KO
EP
WT
WT
KO
WT
F IPGTT 600 WT
500
KO
400 300
200 100
0
0
AC C
mg/dl
25.0
Glucose (mg/dl)
Body Weight (g)
35
140
RI PT
A
KO
0 0
30 60 90 Time (min)
120
Figure S3 related to Figure 5 Metabolic characteristics of 7 month old Adrx null mice. Body weight growth (A), Body composition lean (B) and fat (C) mass, fasting serum glucose (D) and insulin (E) and glucose tolerance (F) were measured from 7month old adrx null and wild type mice.
ACCEPTED MANUSCRIPT
LFD
A. Male
HFD
RI PT
Adrx aP2
SC
Tubulin
TE D d.
Adrx
aP2 Tubulin Actin
LF HF
AC C
EP
C.
M AN U
B. Female
Actin
Figure S4 related to Figure 5 Adiporedoxin expression is reduced in epididymal adipose tissue from obese, high fad fed (HFD) male mice. A. Male (6/condition) and female B (5/condition) were fed a "chow” (LFD) diet or a HFD for 14 weeks and the expression of the indicated proteins in white adipose tissue lysates was determined by immunoblotting following SDS-PAGE. B. The gels were scanned and quantitatively analyzed as in other figures (mean +S.E.M., p< 0.05, n = 6). C. Serum HMW adiponectin was measured in the mice from A and plotted as the ratio of HMW/total adiponectin normalized to adipocyte Adrx/tubulin.
S2212-8778(15)00172-6
DOI:
10.1016/j.molmet.2015.09.002
Reference:
MOLMET 267
To appear in:
Molecular Metabolism
Received Date: 19 August 2015 Revised Date:
28 August 2015
Accepted Date: 3 September 2015
Please cite this article as: Jedrychowski MP, Liu L, Laflamme CJ, Karastergiou K, Meshulam T, Ding S-Y, Wu Y, Lee M-J, Gygi SP, Fried SK, Pilch PF, Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes, Molecular Metabolism (2015), doi: 10.1016/ j.molmet.2015.09.002. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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Adiporedoxin, an upstream regulator of ER oxidative folding and protein
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secretion in adipocytes
Mark P. Jedrychowski1,3, Libin Liu1, Collette J. Laflamme1, Kalypso Karastergiou2,
Tova Meshulam1, Shi-Ying Ding1, Yuanyuan Wu2, Mi-Jeong Lee2, Steven P. Gygi3,
Departments of Biochemistry, Boston University School of Medicine, 715 Albany Street,
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Susan K. Fried2 and Paul F. Pilch1, 2*
Boston, MA 02118. USA. 2
Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston,
MA 02118. USA.
Department of Cell Biology, Harvard University School of Medicine. 240 Longwood Avenue
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Boston, MA 02115, USA.
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*Corresponding author: Paul F. Pilch, Department of Biochemistry, Boston University School of Medicine, 72 E. Concord St., Boston, MA 02118. Phone 617-638-4044, email: [email protected] 1
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Abstract Objective
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Adipocytes are robust protein secretors, most notably of adipokines, hormone-like polypeptides, which act in an endocrine and paracrine fashion to affect numerous physiological processes such as energy balance and insulin sensitivity. To understand how such proteins are assembled for
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secretion we describe the function of a novel endoplasmic reticulum oxidoreductase, adiporedoxin (Adrx).
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Methods
Adrx knockdown and overexpressing 3T3-L1 murine adipocyte cell lines and a knockout mouse model were used to assess the influence of Adrx on secreted proteins as well as the redox state of ER resident chaperones. The metabolic phenotypes of Adrx null mice were characterized and
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compared to WT mice. The correlation of Adrx level and BMI, adiponectin levels, and other inflammatory markers from adipose tissue of human subjects were also studied.
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Results
Adiporedoxin functions via a CXXC active site, and is upstream of protein disulfide isomerase
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whose direct function is disulfide bond formation, and ultimately protein secretion. Over and under expression of Adrx in vitro enhances and reduces, respectively, the secretion of the disulfide-bonded proteins including adiponectin and collagen isoforms. On a chow diet, Adrx null mice have normal body weights, and glucose tolerance, are moderately hyperinsulinemic, have reduced levels of circulating adiponectin and are virtually free of adipocyte fibrosis resulting in a complex phenotype tending towards insulin resistance. Adrx protein levels in
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human adipose tissue correlate positively with adiponectin levels and negatively with the inflammatory marker phospho-Jun kinase.
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Conclusion These data support the notion that Adrx plays a critical role in adipocyte biology and in the regulation of mouse and human metabolism via its modulation of adipocyte protein secretion.
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Keywords
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Adipocyte, adipokine, protein secretion, endoplasmic reticulum, oxidoreductase, disulfide
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bond formation.
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1. INTRODUCTION: In addition to fat storage and release, white adipose tissue (WAT) makes and secretes adipokines, hormone-like polypeptides, which act in an endocrine and paracrine fashion to affect
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numerous physiological processes such as energy balance and insulin sensitivity [1, 2]. In addition, fat cells in adipose tissue are maintained as an organ by extracellular matrix proteins including multiple collagen isoforms whose cellular origin is not completely clear [3]. The initial
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folding and assembly of all secreted and integral membrane proteins, takes place in the endoplasmic reticulum (ER) and is mediated by the actions of numerous enzymes and
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chaperones [4-6]. About 1/3 of all cellular proteins pass through the ER and the vast majority of these have inter- and/or intra-molecular disulfide bonds, the formation of which also takes place in the ER mediated by oxidoreductases of the thioredoxin superfamily [6-8]. Improper disulfide bond formation leads to protein misfolding and, potentially, ER stress, which can have
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deleterious consequences for cells, for example, apoptosis in the endocrine pancreas due to insulin misfolding [9, 10]. Therefore, while normal ER function is essential in all cells, it is especially important in secretory cells such as adipocytes and pancreatic beta cells.
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Adiponectin assembly and disulfide bond formation impose a particular burden on the
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adipocyte ER because it circulates at high concentrations, ca. 30 nM, yet is turned over quite rapidly in blood [11]. Adiponectin has a complicated tertiary structure with post-translational modifications that include the ER-dependent formation of intermolecular disulfide bonds that are required for oligomerization into its most physiologically relevant form, an octadecamer (the high molecular weight or HMW form) [12-14], as well as hydroxylation, glycosylation and proline isomerization all of which occur in its collagenous domain [15-17]. Adiponectin must therefore be properly and efficiently assembled and secreted at high rates, and malfunctions of
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this process will lead to ER stress in the adipocyte and subsequent perturbation of fat cell and organismal metabolism such as insulin resistance and type 2 diabetes [18]. The assembly and secretion of collagens from adipocytes (and other cells) also requires disulfide bonds [17], and
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excess collagen deposition leads to a fibrotic pathology in adipose tissue [19].
What little is known about disulfide bond formation in the adipocyte ER, bond formation
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involves adiponectin assembly, which requires the action of the enzyme endoplasmic reticulum oxidoreductase 1α (ERo1α), a primary electron acceptor that uses molecular oxygen and a flavin
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nucleotide to initiate oxidative protein folding [20]. ERo1α does not interact directly with substrates such as adipokines to mediate S-S bond formation, rather it oxidizes members of the protein disulfide isomerase (PDI) family, which interact with substrates and mediate correct disulfide bond formation and protein folding [20-22]. ERo1α has also been shown to interact
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with endoplasmic reticulum protein, ERp44, to mediate what has been called dynamic ER retention of substrates [23]. The combined actions of ERo1α and ERp44 have been shown to play a role in adiponectin assembly and secretion [24, 25]. A third PDI relative implicated in
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adiponectin multimerization is the disulfide bond A oxidoreductase-like protein (DsbA-L) [26]. Unlike ERo1α and ERp44, it lacks both active site cysteines required for redox function and a
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classical ER localization signal, but it may instead have a chaperone function in protein folding. None of the above proteins has a notable tissue-specific distribution although the expression of DsbA-L is somewhat higher in adipose than in other tissues examined, and it is induced upon differentiation of 3T3-L1 cells [26]. We performed a proteomic analysis of GLUT4 storage vesicles (GSVs) that were selectively immunoadsorbed with anti-GLUT4-coupled beads following depletion of GLUT4-
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precursor compartments [27]. Amongst the proteins we discovered in the GSV-precursor membranes were several potential ER residents including one that was known at the time only as a possible secreted protein (c10orf58) whose mRNA was expressed in human testes [28]. Its
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sequence revealed a CXXC motif, which is the active site sequence of an oxidoreductase [6, 21]. We determined by qPCR that its mRNA was expressed in mouse testes, but we also saw that mRNA expression in brown and white fat was an order of magnitude higher than in any other
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mouse tissue except testes (data not shown), which we confirm here for protein expression (Figure 1). Consequently, we are calling this molecule adiporedoxin (Adrx), and we show here
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that it plays an important role in the assembly and secretion of disulfide-bond containing proteins, in particular, adiponectin in murine and human cells and adiponectin and collagens in murine cells. Its absence in mice leads to a complex and mixed phenotype of lower adipokine secretion and lower adipocyte collagen deposition along with adipocyte ER stress and
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hyperinsulinemia.
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2. MATERIALS AND METHODS 2.1. Animals.
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Primary adipocytes from male Sprague-Dawley rats (175-200 g, Harlan Laboratories, Indianapolis, IN) were isolated and fractionated as described [27]. The same fractionation protocol was performed for 3T3-L1 cultured murine adipocytes. Age matched, 8 week old
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C7BL/6 male and female mice were purchased from Jackson Laboratory (Farmington, CT), maintained at 22°C with a light-dark cycle (light from 0700 to 1900h), and allowed free access to
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food and water. At 10 weeks of age, mice were body weight matched into groups fed either HF (45% of calories, mainly as lard) or LF (15%) diets, then sacrificed as described [29]. All females were euthanized at the pro-estrus phase. For Adrx tissue distribution, mice were perfused with PBS, tissues were carefully dissected with particular attention to removing any fat, immediately mechanically homogenized in a tissue grinder with RIPA buffer containing a
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protease inhibitor cocktail and subjected to a 1000 x g spin to remove debris. The supernatant was collected for SDS-PAGE and Western blot analysis. For fat tissue, the infranatant below the
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fat cake was collected for analysis.
The Adrx knockout mice were generated by microinjecting targeted ES cells (KOMP, derived
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from C57BL/6N, VG15730, clone 15730A-H5) into C57BL/6N blastocysts, and these gave rise to male chimeras with significant ES cell contribution (as determined by coat color). By mating with C57BL/6N females and genotyping the offspring by PCR analysis, germ line transmission was confirmed. Male and female heterozygous F1 animals were interbred to obtain Adrx knockout (Adrx KO) animals. Male animals only were analyzed at >8 weeks of age. The animals were maintained in a pathogen-free animal facility at 22°C under a 12-h light/12-h dark cycle with access to a standard rodent chow. Except when specifically noted, all mice used for in vivo 7
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or in vitro studies were fasted for 4-6 hours starting from early morning prior to use. For tissue harvesting, mice were sacrificed under CO2 anesthesia, and tissues were rapidly taken and immediately frozen in liquid nitrogen and stored at -80°C until biochemical analysis. Tissue and
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cell secreted collagen content was measured using Sirius Red Total Collagen Detection Kit (Chondrex, Redmond, WA, #9062). Mouse serum total and HMW adiponectins were measured
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by using ELISA kit from ALPCO (Salem, NH, #47-ADPMS-E01). 2.2. Primary human adipose cells.
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Human adipose stromal vascular cells (SVC) were isolated from adipose tissue by collagenase digestion, grown and differentiated as previously described [30]. Adipocytes (day 10 post differentiation) were transfected with control or a combination of two Adrx-directed siRNA (SI04213587 and SI04959066, Qiagen, Hilden, Germany) using Lipofectamine and PLUS
2.3. Cell Culture.
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reagents (Life Technologies, Carlsbad, CA).
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Murine 3T3-L1 cells were cultured, differentiated, and maintained as described previously (Stephens et al., 1997). Human embryonic kidney (HEK)-293T cells were cultured in DMEM
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with 10% FBS. For Adrx overexpression, confluent 3T3-L1 fibroblasts were infected with a pBABE retrovirus construct driving Adrx cDNA using the following oligo primers: sense sequence containing BamH1 restriction site, 5’-ttttggatccatgtcttttctccaggac-3’ and an antisense sequence containing an EcoR1 restriction site, 5’ttttgaattctcagcttctcccggacgctggagt-3’, then differentiated for subsequent analysis as fat cells. Site directed mutagenesis of Adrx was performed using a Quickchange Mutagenesis Kit (Agilent, Santa Clara, CA) following the manufacturer's instructions. 8
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For Adrx silencing, mouse lentiviral vectors driving several shRNA sequences were purchased from Open Biosystems (Huntsville, AL) and transfected into HEK-293T cell with trans-IT 293 (Mirus, Madison, WI) according to the manufacturer’s instructions. Supernatant containing
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retrovirus was harvested 48 hrs later and used to infect confluent 3T3-L1 fibroblasts prior to their differentiation. Four pLKO.1 c10orf58 mouse lentiviral vectors were tested. All sequences were effective with target # 3 showing the best knockdown efficiency (>90%), and it was used for all
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of the adiporedoxin studies.
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2.4. QPCR.
Total RNA was isolated, quantified and reverse-transcribed using a commercial cDNA synthesis kit. Quantitative PCR (qPCR) was performed with commercially available TaqMan probes (Thermo Fisher Scientific) or SYBR primers. Primer sequences will be available upon request.
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2.5. Gel Electrophoresis and Immunoblotting. Proteins were resolved by SDS-PAGE as described [31]. Non-denaturing PAGE separation of
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adiponectin oligomers was performed as described [13]. Gels were transferred to polyvinylidene difluoride (Biorad, Hercules, CA) membranes pretreated with methanol in 25 mM Tris, 192 mM
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glycine. Membranes were blocked with 10% nonfat dry milk in PBS containing 0.1% Tween 20 for 1 hour at room temperature. Membranes were then probed with the primary antibodies for either overnight at 4 °C or 2 hrs at room temperature and incubated with Horseradish peroxidaseconjugated secondary antibodies (Sigma-Aldrich, St. Louis, MO). Signals were enhanced with chemiluminescence reagents (Perkin Elmer Life Sciences, Boston, MA) for detection of Western signals using a Fujifilm LAS-4000 scanner or Autoradiography Film (Molecular Technologies, St. Louis, MO). Antibodies to the indicated proteins were from the following sources: GLUT4, 9
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cellugyrin, IRAP and Adrx (21st Century Biochemical, Hopkinton, MA); adipsin (Santa Cruz Biotechnology, Inc., Santa Cruz, CA); ERo1-α (Abnova, Taipei, Taiwan); adiponectin (Affinity Bioreagents, Golden, CO); β-actin, tubulin (Sigma-Aldrich, St. Louis, MO); DsbA-L and
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calnexin (Abcam, Cambridge, MA). Antibodies to the following were generous gifts: aP2 (Dr. David Bernlohr, University of Minnesota), insulin receptor (Dr. Jongsoon Lee, Joslin Diabetes
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Center). 2.6. Immunofluorescence.
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On Day 6 of differentiation, cells were trypsinized and plated onto coverslips in 6 well plates. On day 8 of differentiation cells were fixed with 4% paraformaldehyde in PBS for 15 minutes at room temperature and permeabilized with 0.1% saponin (Sigma-Aldrich, St. Louis, MO), 0.4% BSA in PBS (solution A) for 10 minutes and then blocked for 1 hour at room temperature in 5%
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normal goat serum (Sigma-Aldrich, St. Louis, MO) in PBS. Primary antibodies were incubated with fixed cells overnight at 4°C at a dilution of 1/100 in 1% normal goat serum in PBS. After staining cells were washed four times with solution A and incubated with Alexa-Fluor 488 anti-
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mouse or Alexa-Fluor 555 anti-rabbit (Life Technologies, Carlsbad, CA) at a dilution of 1/1000 in 1% normal goat serum in PBS for 1 hour at room temperature. The cells were washed again
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for 3 times with solution A and then mounted with Vectashield mounting medium with DAPI (Vector Laboratories, Burlingame, CA, USA). The stained cells were observed using a Nikon deconvolution wide-field Epifluorescence system and images were processed using NIH ImageJ software (http://imagej.nih.gov/ij/). 2.7. Mass Spectrometry. 2.7.1. Sample preparation and peptide TMT-labeling. Cultured adipocytes were lysed with a 10
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mechanical homogenizer, disulfide bonds were reduced with DTT, and cysteine residues alkylated with iodoacetamide essentially as previously described [32]. Isobaric labeling of the peptides was accomplished with six-plex tandem mass tag (TMT) reagents (Thermo Scientific,
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Rockford, IL). Reagents, 0.8 mg, were dissolved in 40 µl acetonitrile (ACN) and 15 µl of the solution were added to 100 µg of peptides dissolved in 100 µl of 50 mM HEPES, pH 8.5 After 1 hour at room temperature, the reaction was quenched by adding 8 µl of 5% hydroxylamine.
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Peptides were labeled with all six reagents (126-131), combined and subjected to C18 SPE.
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2.7.2. Liquid chromatography electrospray ionization tandem mass spectrometry (LCMS/MS).
All LC-MS/MS experiments were performed on an LTQ Orbitrap Velos (Thermo Scientific, Rockford, IL) equipped with a Famos autosampler (LC Packings, Sunnyvale, CA) and an
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Agilent 1100 binary HPLC pump (Agilent Technologies, Santa Clara, CA) as described [33]. 2.7.3. Data processing: MS2 spectra assignment, data filtering and quantitative data analysis
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Assignment of MS2 spectra was performed using the Sequest algorithm by searching the data against a protein sequence database containing all known translated proteins from the mouse IPI
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database (version 3.60), and known contaminants such as porcine trypsin, and human keratin. This forward (target) database component was followed by a decoy component including all listed protein sequences in reversed order. For quantification, the total signal intensity across all peptides quantified was summed for each TMT channel, and all intensity values were normalized to account for potentially uneven TMT labeling. The intensities for all peptides of a given protein were summed to derive an overall
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protein abundance value for each TMT signal. Hierarchical clustering using Pearsons correlational analysis was conducting using MultiExperiment Viewer (TM4 Microarray Software
performed using JMP statistical software (version 10 Pro).
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Suite) (Saeed et al., 2006) and Principle component analysis based on correlations was
Protein ratios across Adrx cell lines between KD to control and OE to control were calculated
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based on their normalized TMT ratios. Principle component (PCA) analysis, GO classifications and enrichment calculations were performed using DAVID online bioinformatics tools. The
Molecular
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resulting clusters are plotted for GO Cellular Components, GO Biological Processes and GO Function annotations. Representative proteins are highlighted with their
corresponding ratios. 2.8. Pegylation Assay.
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3T3-L1 cultured adipocytes at day 8 of differentiation were treated with 5 mM dithiothreitol (DTT) for 5 min, 3 mM diamide for 5 min, or various concentrations of H2O2 for 10 min. Cells were denatured and precipitated in ice-cold PBS containing 20% trichloroacetic acid (TCA),
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incubated on ice for 1 h, and centrifuged at 10,000 rpm for 15 min at 4°C. The supernatant was
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discarded and the pellet was washed 3 times with ice-cold acetone, dried, and resuspended in reaction buffer (80 mM Tris-HCl, pH 6.8, and 2% SDS) containing 5 mM methoxypolyethylene glycol (average molecular weight, 2000)-maleimide (MalPEG-2K) (NOF Corporation, White Plains, NY) [34]. Samples were left in the dark for 60 min at room temperature. The alkylation reaction was stopped by boiling for 5 min after the addition of an equal volume of 4X Laemmli loading buffer.
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2.9. Study approval. The animal studies were approved by the Institutional Animal Care and Use Committee and the human fat cells were obtained from subjects who gave informed consent
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as approved by Institutional Review Boards of Boston University School of Medicine.
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3. RESULTS: 3.1. Adiporedoxin (Adrx) is an ER protein highly expressed in white (WAT) and brown
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(BAT) adipose tissue and is induced during adipocyte differentiation. Figure 1A shows the sequences of mouse and human Adrx with their –CXXC- active sites (red) and transmembrane (TM) region/leader sequences (green underlined), both domains indicated in the cartoon of Figure 1B. Figure 1C and 1D show respectively, the tissue
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distribution of Adrx protein in mice and the time-dependency of its expression as a function of
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3T3-L1 adipocyte differentiation. As expected, Adrx protein expression was relatively high in testis, and although great care was taken in removing fat from the other tissues, traces of Adrx (compared to fat and testes) can be observed in small intestine and spleen, which probably reflects low level expression in those tissues (Figure 1C). Like many proteins that are highly expressed in adipocytes, GLUT4 for example [35], Adrx was markedly induced as preadipocytes
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differentiate (Figure 1D). Like the murine cells, cultured human adipocytes express Adrx mRNA and protein in a differentiation dependent fashion and its knockdown in these cells results in diminished adiponectin secretion (Figure S1). Adrx mRNA is also expressed in human adipose
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tissue to a much greater degree than in other human organs (Figure S1).
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We determined by sucrose gradient fractionation in primary rat adipocytes (Figure 1E) that Adrx was colocalized with the ER membrane marker, calnexin (Cnx) [36], and was well separated from GLUT4-rich vesicles. Its partial co-localization with cellugyrin (CG), a marker for diverse intracellular vesicles [37], accounts for its appearance in GSV precursor membranes that allowed its initial identification [27]. To put Adrx into the context of other possible ER contributors to fat cell ER function, disulfide bond formation and protein secretion, we subjected membranes from 3T3-L1 adipocytes to sucrose gradients and showed that Adrx overlaps 14
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significantly with proteins of the ER lumen, namely adiponectin (Adpn), ERo1α and PDIa1 (Figure 1F). These last three proteins are soluble and were partially released from the ER during cell fractionation and therefore migrated at the top of the gradient, whereas Adrx did not,
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confirming its integral membrane association. On the other hand, DsbA-L distributed only to the top of the gradient, indicating that it is unlikely to be a resident of the ER lumen. Lastly, we confirmed by immunofluorescence microscopy in 3T3-L1 adipocytes, the nearly complete co-
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localization of Adrx with calnexin, its partial localization with adiponectin and its minimal, if
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any, co-localization with porin [38], hence mitochondria (Figure 1G). 3.2. Adrx levels affect adiponectin and collagen secretion.
Given the CXXC motif of adiporedoxin and its ER localization, its role in disulfide bond formation and subsequent protein secretion seemed likely. Thus we generated Adrx knockdown
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and overexpressing 3T3-L1 cells (Figure 2A) and monitored secreted (Figure 2B-C) adiponectin and collagen (Figure 2D) comparing them to control (scrambled shRNA). As previously noted, adiponectin is found circulating in what are often termed low, medium and high molecular
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weight oligomers corresponding to trimer, the first formed disulfide-linked oligomer (LMW), hexamer (MMW) and larger oligomers (HMW) [14]. As shown in Figure 2B in a non-
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denaturing, non-reducing gel for 4 hours of secretion, all Adpn multimers were affected to the same extent by alterations in Adrx expression. That is, secretion is inhibited in the knockdown cells and enhanced in the over expressing cells as compared to controls and this is shown quantitatively in Figure 2D. As noted in the Introduction, adiponectin and collagen have some similar features, disulfide bonds, a triple helical region and post-translational modifications, and we also determined the effects of altered Adrx expression on collagen secretion. It is inhibited or enhanced, respectively, by Adrx knockdown and over expression (Figure 2D). Moreover, and 15
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like cultured fat murine cells (Figure 2B), siRNA mediated knockdown of Adrx in primary human adipocyte cultures inhibited the secretion of all adiponectin oligomers (Supplemental Figure 1). Thus, these aspects of Adrx biochemistry in vitro appeared identical in mouse and
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human fat cells.
If the overall effect of Adrx expression levels results in altered assembly of mature
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proteins, hence altered secretion, we would expect that cell-associated adiponectin would be enhanced by its knockdown and decreased by its over expression and this is exactly what we
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observe (Figure 2A). In addition, the insulin receptor which has numerous intra- and intermolecular disulfide bonds [39] also shows altered expression due to Adrx manipulation, as expected, less receptor in the knockdown and more in the over expressers (Figure 2E). In this case, it was the steady state levels of an integral membrane protein that were being altered.
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3.3 Adiporedoxin is a redox-regulated protein, which catalyzes the oxidation of ER
To directly confirm that Adrx functioned as a redox-regulated protein, we used N-
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ethylmaleimide PEGylation [40] to assay for changes in the adipocyte ER oxidation state as reflected by mobility shifts in Adrx and PDIa1. This reagent covalently reacts with reduced
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cysteines and retards protein mobility by 2K when run in non-reducing SDS-PAGE. As shown in Figure 3A, control cells exhibited a mixture of oxidized and reduced PDI and Adrx, and cells treated with the strong oxidizing reagent diamide [41] showed fully oxidized proteins and cells treated with the reducing agent, dithiothreitol (DTT), showed reduced mobility due to PEGylation. As a control, a mutant Adrx (SFLS) lacking the two active site cysteines did not show this shift (Figure 3A, right hand panel).
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To determine if Adrx could affect protein secretion through re-oxidation of chaperone proteins, we determined the redox state of PDIa1 in cells over and under expressing adiporedoxin (Figure 3B & 3C). Knocking down Adrx decreased the oxidized form of PDIa1 in
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the basal state and in response to all doses of hydrogen peroxide (Figure 3B). Overexpression of Adrx caused a slight but statistically insignificant increase in the oxidized forms of PDIa1
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(Figure 3C) consistent with the enhanced secretion under these conditions. 3.4. Adrx expression levels affect the adipocyte proteome
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We used Tandem Mass Tag technology (TMT) and quantitative mass spectrometry [42, 43] to interrogate the proteome of control 3T3-L1 adipocytes (CON) and Adrx overexpressing (OE) and knockdown (KD) adipocytes. Overall, we were able to identify ca. 4500 proteins at a 1% protein false discovery rate (Supplemental Table S1). Principal component analysis (Figure
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4A) of the proteomic data shows good agreement between the biological replicates, and we observed that the majority of the proteome was unaffected by Adrx expression. Figure 4B shows a heat map of all proteins quantified and Gene ontology (GO) enrichment analysis for proteins in
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the overexpressing cells showed a significant increase in cell associated oxidoreductase and thioredoxin-related proteins and decreases in secreted adiponectin and collagen (Figure 4C), the
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latter two as would be expected from the data of Figure 2. Thus the amount of cell-associated, disulfide-bonded adipokines, adiponectin (Adpn) and resistin (Rtn) [44, 45] was less than in controls in the Adrx overexpressing cells and increased (cell retention) in the Adrx knockdown cells. On the other hand, serum amyloid A3 protein, which lacks S-S bonds [46], does not change as a result of altered Adrx expression (Figure 4C). The expression of the three specific collagen chains indicated in Figure 4C (see also Supplemental Tables S1 and S2) were affected by
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alterations in Adrx levels in a manner similar to adiponectin in confirmation of the biochemical analysis of Figure 2D.
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3.5. Adrx null mice show decreased adipokine secretion, have mild ER stress and are hyperinsulinemic.
In order to obtain data for the effects of Adrx levels in vivo, we introduced into mice ES
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cells obtained from KOMP for a gene construct that deletes exons 2-6, and we generated Adrx knockout mice. The mRNA expression for WT, heterozygous and Adrx null mice is shown in
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Figure 5A and protein expression data for the WT and knockouts are shown in Figure 5B and quantitatively analyzed in Figure 5C. The mice exhibited increased adiponectin retention and increases in components of the ER protein maturation machinery, BiP and ERo1α (Figure B, C) as well as in a number of mRNAs encoding ER stress proteins and inflammatory markers
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(Supplemental Figure S2). Mass spectrometric analysis of intact epididymal fat tissue from WT and Adrx knockout mice confirmed that adiponectin and other adipokines show higher cellular levels (enhanced retention implying reduced secretion) in the knockout as compared to WT
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(Supplemental Table S2), The WT and null mice are the same weight (Figure 5D) and body composition (Figure S3B, S3C), and the nulls have decreased levels of circulating HMW
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adiponectin (5E) as was expected from the in vitro data (Figure 2 and 3). The knockout mice have normal blood glucose (5F) are mildly hyperinsulinemic (5G), but have normal glucose tolerance (5H).
3.6. Adrx null mice are protected from fibrosis due to decreased collagen deposition. Remarkably, while the epididymal adipose tissue from WT mice at age months 7 stains strongly for collagen deposition, the epididymal adipose tissue from Adrx null mice is essentially 18
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free from fibrosis (Figure 5I), and as determined by mass spectrometry (Supplemental Table S2), the Adrx null mice had lower levels of 14 collagen isoforms including collagen chains 6a1, a2, a3 & a5, the most abundant species we detected in adipose tissue (see also Figure 4C and [47]).
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Biochemical analysis of total collagen confirmed the mass spectrometry data (Figure 5J). Thus the in vivo collagen expression data are consistent with the adipose tissue staining (Figure 5I) and the results from the in vitro mass spectrometry analysis and quantification (Figure 2C and
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4C). Interestingly, at age 6-7 months, the Adrx null mice are the same weight and body
fasting insulin (Supplemental Figure S3).
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composition as wild type mice, have identical glucose tolerance but have significantly higher
3.7. Adrx is expressed in human adipocytes and down regulated in proportion to the level of inflammation.
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Adrx mRNA in human adipose tissue was tightly correlated with adipose tissue adiponectin mRNA in both sexes (Figure 6A, males, 6B, females) after statistical adjustment for BMI, which had a negative effect on adiponectin mRNA (Figure 6A & B, right panels). A
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similar correlation was noted for Adrx protein and tissue adiponectin, independent of BMI R=0.53, p<0.01 in males; 2R=0.49, p<0.0001 females, data not shown). In addition, tissue Adrx
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protein levels were inversely related to the ratio of pJNK to total JNK protein for fat cells of both sexes (Figure 6C), pJNK being a marker of inflammation in human adipose tissue [48], and this association was independent of BMI in multiple regression models (data not shown). Lastly, male wild type mice fed a high fat diet showed elevated adipose inflammation [49] and also showed reduced Adrx levels and reduced circulating adiponectin, whereas females do not show any changes in these parameters (Supplemental Figure S4).
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4. DISCUSSION: We describe herein the actions of adiporedoxin (Adrx), a novel protein highly enriched in
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adipocytes and localized to the endoplasmic reticulum, whose altered expression in vitro in mouse and human cells, and in vivo in mice, results in significant changes in adipocyte protein secretion. In particular, its knockdown in mouse and human fat cells resulted in a significant
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attenuation of adiponectin secretion (Figures 2, 4 and S1), a protein whose expression has been linked with insulin sensitivity [50] and the secretion of collagens (Figure 2, 4, 5 and Supp. Table
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2), proteins which can cause adipocyte fibrosis and insulin resistance [19, 51]. Both types of proteins require disulfide bonds for assembly and secretion. Moreover, we showed by proteomic analysis that Adrx over and under expression enhanced and attenuated, respectively, the secretion of several S-S bonded adipokines including resistin (Figure 4) and adipsin (Western blot not shown) as well as affected insulin receptor amounts (Figure 2), the latter presumably due
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to its large number of disulfide linkages [39]. As most secreted proteins have disulfide bonds, appropriate controls are scarce for the measuring the effects of Adrx on secreted proteins lacking disulfides. However, serum amyloid A protein is such a protein [46], and its secretion is in fact
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unchanged in by manipulation of Adrx expression (Figure 4). Importantly, we confirmed much
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of the protein secretion data in studies of Adrx null mice (Figure 5), which circulate lower levels of HMW adiponectin and are remarkably free of fibrosis due to impaired collagen secretion. Lastly, Adrx protein levels in human fat tissue correlate well with adiponectin protein levels, and inversely with cellular inflammatory markers regardless of BMI. Thus higher levels of Adrx contribute to the maintenance of healthy adipose tissue despite obesity (Figure 6). The data we obtained are consistent with Adrx acting at an early step in the secretory pathway of adipocytes. Thus reduced Adrx expression in the context of ER oxidative stress 20
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(hydrogen peroxide, Figure 3) results in impaired redox regulation of PDIa1, the most abundant adipocyte chaperone found in our proteomic analysis of mouse adipose tissue (Supp. Table 2), which is directly involved in disulfide bond formation [21]. Adrx appears to be in the
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peroxiredoxin (Prx) family of redox-regulated proteins [52] that have diverse biological functions in a variety of cell types, reduction of peroxides being their eponymous activity [53]. The only other endoplasmic reticulum localized peroxiredoxin, Prdx4, functions in the formation
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of disulfide bonds indirectly, probably by regulating the amount of reactive oxygen species, principally hydrogen peroxide [54, 55]. As noted, disulfide bond formation is directly mediated
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by protein disulfide isomerases (PDIs) whose active sites have two or three -CGHC- sequences along with a chaperone fold consisting of about 130 amino acids with four beta sheets and 3 alpha helices [21]. The PDIs bind to substrates, form and if necessary, reform and correct their disulfide bonds, although many details of the process remain unclear [34]. On the other hand,
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adiporedoxin has a unique thioredoxin active site sequence, -CFLC-, not found in other PDI/Trx proteins, nor in the other peroxiredoxin family members, including Prdx4, as peroxiredoxins have cysteines widely separated in their primary protein sequences and function as multimers
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[53]. Moreover, unlike most members of the PDI family and Prdx4, which are soluble in the lumen of the organelle, Adrx is a transmembrane protein (Figure 1) similar to the transmembrane
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thioredoxin-like protein 4 (TMX4) only with respect to its ER membrane location [40, 56]. Based on the data of Figure 3, we hypothesize that Adrx has a function unique to
adipocytes that likely involves its ability to deal with metabolically related ER oxidative stress and to mediate protein secretion under these conditions. Recent related work on the role of various ER proteins involved in oxidative protein folding and disulfide bond formation has revealed redundancies and complementary roles for multiple PDI/Trx-related proteins [34, 55],
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fourteen of which are expressed in the adipocyte ER (Supplemental Tables S1, S2, see also [47]). The relatively modest metabolic phenotype of the Adrx null mice, similar in that respect that to the ERo1α/ERo1β knockout [57], likely reflects this complexity and redundancy in ER
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oxidoreductase function. On the other hand, the biochemical phenotype of the Adrx null mouse with regard to collagen secretion is particularly robust. Thus, considerable additional work will be required to define the biochemical role of Adrx more precisely and its hierarchical role in
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adipocyte ER redox regulation, and this is in progress. Adrx has previously been reported in one publication naming it peroxiredoxin 2-like protein expressed in bone marrow monocytes
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(PAMM, also known as Fam213a) [52] that affects cellular redox status, a result consistent with the present data. Its expression in fat tissue was not examined in the cited study, but the authors showed protein to be expressed in human liver, brain and other tissues, at what appears to be one or more orders of magnitude lower than in adipocytes, as compared to our data on Adrx levels in
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these mouse tissues (Figure 1). These authors showed a minor extent of PAMM mRNA upregulation and protein in macrophage colony-stimulating factor activated bone marrow monocytes in vivo, but subsequent verification of its redox function was performed in transfected
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established.
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cells in vitro. Thus a physiological function in vivo for PAMM in monocytes was not definitively
A second aspect of Adrx function in adipocytes concerns the biochemical nature of the
most abundant secreted molecules of these cells, adiponectin and collagen. These proteins are particularly interesting, not only for reasons of their abundance and important physiological role(s), but also for the fundamental biochemistry and cell biology of their complicated quaternary structures, post translational modifications including intermolecular disulfide bond formation [16, 58]. The adiponectin trimer consists of an intermolecular disulfide link between 2
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monomers and a free SH group on the 3rd subunit, which is then disulfide bonded to another trimer to form the hexamer [12, 59, 60]. Likewise, intrachain disulfide bonds between the N- and C-terminal propeptide sequences are necessary to form the signature triple helix structure of
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collagens [58] before their movement out of the ER. The striking biochemical phenotype of the Adrx knockout mouse emphasizes Adrx’s roles as a particular modulator of collagen secretion and that of related proteins. Regarding adiponectin, previous studies have documented a direct
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interaction of an adiponectin cysteine residue with one in ERp44, which bond can be released by reducing agents or by increasing ERo1α levels [24]. This mechanism, enhanced retention, is
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analogous to the assembly of IgK [61, 62]. However, adipsin has only intermolecular disulfides [63] and the insulin receptor has both types of bonds [39]. This would support the above stated notion that Adrx plays a broad role early in disulfide bond formation, e.g. ER redox status, such that a compromise in its activity reduces the overall levels of most or all disulfide bonded
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integral membrane and secreted proteins. DsbA-L was shown to directly interact with adiponectin in yeast-2 hybrid studies and to promote its multimerization [26]. DsbA-L was also shown to alleviate the effects of adipocyte ER stress on adiponectin levels [64], but it does not
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appear to be a luminal ER resident (Figure 2), presumably a requisite for a direct role in oligomer assembly, and its knockout in mice is without effect on adiponectin multimerization [65]. Thus a
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further examination, in vitro and in vivo, of the possible players in adipocyte protein secretion is needed to resolve the specific roles of these proteins in the formation of adipokines and integral membrane proteins and to further elucidate their mechanism(s) of action. Given its pleiotropic action on adipokines and other secreted proteins related to insulin sensitivity, the relationship of Adrx levels to pathophysiological states in mice and humans is likely to be complex. Indeed, we see no dramatic effects of Adrx deficiency on systemic glucose
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utilization in null mice on a chow diet (fasting glucose and glucose tolerance, Figure S3). However, lower circulating HMW adiponectin levels and mild hyperinsulinemia would suggest some degree of insulin resistance. Moreover, fibrosis, while present in WT animals, is virtually
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absent in the epididymal fat pad of older Adrx deficient mice, and this should enhance the metabolic flexibility and the insulin sensitivity of adipose tissue and the entire mouse and, therefore, could compensate for the effects of hypoadiponectinemia and hyperinsulinemia at least
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with regard to glucose tolerance. In human adipose tissue we also found a close correlation between Adrx and adiponectin levels in both men and women, independent of BMI.
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Furthermore, higher expression of activated (phosphorylated) JNK, a marker of ER stress, inflammation and insulin resistance [48] was inversely correlated with Adrx protein (Figure 6C). In WT male mice following 12 weeks of a high fat diet, which results in insulin resistance, reduced adipocyte Adrx protein correlates with lower circulating adiponectin (Supplemental
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Figure S4). Taken together, the data from mice and humans point to a positive effect of Adrx protein levels in ameliorating insulin resistance, although the relative contribution(s) in this regard of adipocyte secretory proteins downstream of this protein remain to be fully elucidated.
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Thus, we postulate that Adrx may be down regulated in response to the metabolic and inflammatory status of adipose tissue and this mechanism contributes to lower adiponectin levels
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in obese humans, which is likely to be one of several factors influencing the metabolic status of the individual. In summary, adiporedoxin is clearly an important contributor to fat cell biology in mice and humans and one that participates in and regulates novel aspects of the secretory pathway in these cells of relevance to basic cellular functions, organismal metabolism and pathology.
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ACKNOWLEDGMENTS We thank Dr. Tsu-shuen Tsao, University of Arizona for help with the non-denaturing gels for
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adiponectin and Dr. Alessandro Peschechera for critical reading of the paper. This work was supported by the NIH: DK-30425 and DK-092942 to PFP; DK-52398, DK-080448, P30 DK046200 to SKF; DK104369 to SKF and PFP and HG3456 to SPG. The authors declare no
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competing financial interests. Appendix supplementary data
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The following are the supplementary data related to this article Supplementary Table 1
Supplementary Table 2
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Proteomic analysis of 3T3-L1 cells over and under expressing adrx.
Selected proteins from a TMT proteomic analysis of epididymal adipose tissue from WT and
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adiporedoxin null mice
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Supplementary Figure 1
Adrx expression in human adipocytes parallels that in mouse fat cells and affects adiponectin secretion. The mRNA distribution of Adrx A. and adiponectin B. in abdominal subcutaneous adipose tissue (AT), and isolated fat cells (FC) and stromal-vascular fractions (SVF) obtained after collagenase digestion is shown in comparison to the other tissues lindicated (n=3). C. Adrx mRNA and protein shows a marked increase in expression during the differentiation of human preadipocytes. The data are expressed as % of one of the 4 cultures that was set to an arbitrary
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value of 1. D. (I.-IV.) shows that knockdown of Adrx mRNA and protein did not decrease adiponectin mRNA, but markedly decreased the secretion of (HMW) and lower molecular weight forms (MMW and LMW) into the medium. The data in all panels are representative of 3
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or more independent experiments. The data in panel D were reproduced in cells from 2 individuals.
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Supplementary Figure 2
Figure S2 related to Figure 5 mRNA Expression of adipocyte ER stress and inflammation
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markers in the Adrx null and wild type mice. A. ER stress markers (HERP: homocysteineinduced ER protein; CHOP: CAAT/enhancer binding protein (C/EBP) homologous protein; EDEM1: ER degradation enhancer, mannosidase alpha- like 1; WARS: tryptophanyl tRNA synthetase; P58IPK: p58 inhibitor of interferon-induced double-stranded RNA-activated protein
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kinase) and B. Inflammatory markers were measured by RT-qPCR from 8-week old adrx null and wild types mice adipose tissue.
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Supplementary Figure 3
Metabolic characteristics of 7 months old Adrx null mice. Body weight growth (A), Body
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composition lean (B) and fat (C) mass, fasting serum glucose (D) and insulin (E) and glucose tolerance (F) were measured from 7- month old adrx null and wild type mice. Supplementary Figure 4
Adiporedoxin expression is reduced in epididymal adipose tissue from obese, high fad fed (HFD) male mice. A. Male (6/condition) and female B (5/condition) were fed a "chow” (LFD) diet or a HFD for 14 weeks and the expression of the indicated proteins in white adipose tissue lysates
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was determined by immunoblotting following SDS-PAGE. B. The gels were scanned and quantitatively analyzed as in other figures (mean +S.E.M., p< 0.05, n = 6). C. Serum HMW adiponectin was measured in the mice from A and plotted as the ratio of HMW/total adiponectin
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normalized to adipocyte Adrx/tubulin.
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FIGURE CAPTIONS Figure 1. Adiporedoxin (Adrx) is an endoplasmic reticulum targeted peroxiredoxin-related
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protein enriched in adipocytes. A. The sequences and domains B. of mouse and human adiporedoxin are shown, highlighting the transmembrane region and the active site cysteines C. The tissue distribution of adiporedoxin
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and adiponectin (Adpn) is shown for equal protein amounts of cell lysates subjected to SDSPAGE and Western blotting detection. D. Adrx protein expression is induced during 3T3-L1 cell
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differentiation from fibroblasts (day 0) to mature fat cells (day 8). An equal protein amount of cell lysates from the days indicated was subjected to SDS-PAGE and immunoblotted for the selected proteins. E. The internal membrane fraction (0.5 mg protein) from isolated primary adipocytes was subjected to sucrose gradient centrifugation; odd-numbered fractions were collected and blotted for the proteins indicated, adiporedoxin (Adrx), calnexin (Cnx), cellugyrin
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(CG) and GLUT4. F. 3T3-L1 cells were lysed, processed and subjected to sucrose gradient analysis as for the primary adipocytes of 1e. Additional proteins analyzed are adiponectin (Adpn), disulfide bond A oxidoreductase-like (DsbA-L), endoplasmic reticulum oxidoreductase
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1-alpha (ERo1α). G. Immunofluorescence of differentiated 3T3-L1 cells comparing the
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localization of Adrx with calnexin, adiponectin (Adpn) and porin. The data for each part of this figure are representative of three or more independent experiments.
Figure 2. Adiporedoxin levels affect the secretion of adiponectin (Adpn) and collagen, and the insulin receptor (IR) levels. Day 8 differentiated murine adipocytes (3T3-L1) infected with Adrx shRNA, WT Adrx cDNA (OE) or a scrambled sequence (-) were washed 3X with serum free medium, and then incubated
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for 4 hours (A-D). Cell lysates and supernatants were harvested, subjected to SDS-PAGE and Western blotted for the indicated proteins. A. Shown is a representative experiment for Adrx knockdown and over expressing cells where lysates were prepared and subjected to SDS-PAGE
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under reducing conditions showing the total cellular levels of Adrx, Adpn and the insulin receptor (IR), actin as the loading control. B. Cell supernatants from a representative experiment were collected from control (-), knockdown (shRNA, +) and Adrx overexpressing cells (OE, +)
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after 4 hours and subjected to non-denaturing, non-reducing gel electrophoresis, the forms as indicated (HMW, MMW and LMW). C. The results of scanned gels for the 3 forms shown in B
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are given as the S.E.M., n=3, P< 0.001 for the over expressers and n=9, P< 0.002 for the shRNA cells, control value set to %100. D. Collagen secretion was measured in a separate series of experiments as in A and the results are from n=6, *P< 0.05. E. Western blotting data for the insulin receptor beta subunit following SDS-PAGE were scanned and statistically analyzed (n=4,
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*p <0.02, **p <0.002).
Figure 3. Adiporedoxin is upstream of PDI in the adipocyte ER redox cascade.
EP
A. 3T3-L1 cells over-expressing WT Adrx (CFLC) or with active site cysteines mutated to serines (SFLS) were treated or not with dithiothreitol (DTT), Diamide (Dia.) or not for 5
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minutes, lysed with 20% TCA, and TCA precipitates were reacted with MalPEG-2K to modify free cysteines. Adrx and protein disulfide isomerase a1 (PDIa1) were visualized by immunoblotting following gel electrophoresis of the TCA precipitates and the reduced and oxidized forms indicated. B. 3T3-L1 cells expressing scrambled or Adrx-targeting shRNA were treated with the indicated concentrations of H2O2 for 5 min., lysed and treated as in Figure 3A.
37
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The bar graph on the right shows the mean ± S.D. for scans of 4 independent experiments (*p< 0.05). C. Same as Figure 3B for Adrx over expressing cells and controls (scrambled shRNA).
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Figure 4. Proteomic analysis of tandem mass tagged (TMT)-labeled whole cell (3T3-L1) lysates confirms Western blot data and reveals pleiotropic cellular changes as result of altered Adrx levels.
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A. Principle component analysis (PCA) analyses of the TMT labeling (Table S1) showed good correlation between biological replicates. Eigenvalues and percentages were calculated for each
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PCA. Graphical representation for each protein by PCA 1 and PCA 2 show the majority of the proteins did not change as a result of altered Adrx levels. Biplots of PCA 1 and 2 show a vector location of each biological sample where the biological duplicates were found to be most similar to each other. B. Heat map showing enrichment of Gene Ontology (GO) categories across Adrx
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cell lines. Indicated to the right of the heat map are those categories that were significantly enriched with Benjamin-Hochberg corrected p < 0.05. C. Relative amounts of cell associated adipokines (adiponectin, Adpn; resistin, Rtn; serum amyloid a, SAA) and selected collagens
EP
(Col1a, 3a, 6a) from Adrx knockdown (KD) and overexpressing (OE) as compared to control (Cont-set to 1.0). The results shown for the TMT experiment compare 2 dishes of each cell line
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(OE, KD, Cont, see Supplemental Table 1) and the entire experiment was repeated twice with similar results.
Figure 5. Adrx null mice show ER stress, hyperinsulinemia and their adipose tissue is free of fibrosis.
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A. Adrx mRNA levels from adipose tissue were examined by RT-qPCR from wild type (WT), heterozygote (Het) and Adrx knockout (KO) mice. B. Whole adipose tissue lysates from WT and KO mice were prepared in RIPA buffer. Protein (10–50 µg, equal amounts, WT & KO) was
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subjected to SDS-PAGE and immunoblotted with the indicated antibodies. C. Quantification of Adrx, Adpn, Bip and Ero1α from 6B, body weight (D), fasting serum insulin (E) and glucose (F), HMW adpn (G), and glucose tolerance test (H) were assessed in WT and Adrx KO mice. I.
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Collagen Masson's Trichrome Stain and J. collagen quantification by using Sirius Red Total Collagen Detection Kit of adipose tissue from WT and Adrx KO mice. 8-week-old strain-
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matched males were used in (a-h), n=3, and 7 months old mice were used in (I-J), n = 6. The statistical values are displayed as means and S.E. (*p < 0.05, **p < 0.01, ***p < 0.001).
Figure 6: Expression of adiponectin and adiporedoxin mRNA positively and strongly
kinase (pJNK) levels.
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correlate independent of BMI and Adrx protein negatively correlates with phospho-jun
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Figure 6 shows mRNA levels of Adrx and adiponectin in men (A) and women (B). Associations were analyzed in a least squares model that including the interaction term
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Adrx*BMI which was significant in the females (p=0.01) but not in the males (p=0.12). The model predicted 60% of the adiponectin variance in the females (R2 = 0.60, n = 30, p<0.001), and 62% in males (R2 = 0.62, n = 16, p< 0.01). C. Quantitative analysis of Western blots of adipocyte lysates for the ratio of p-JNK to total JNK, plotted versus Adrx for both sexes, shows a negative correlation in both males (r = -0.68, n = 16) and female subjects (r = -0.49, n = 29, one outlier excluded).
39
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Figure 1.
SMGMWSIGVG EKNGAVIMAV EIFLDEKKKF KQGILLEHRE
Human Adrx Sequence 1 61 121 181
MSFLQDPSFF PRTFKAKELW VKDFQPYFKG LGGVFVVGSG
B.
C.
14 28
85 88
TM
-CFLC-
LANTDMFLSK EAADLMSLKP MGLIRLGVWY SVLEAVKKIK
PRKAALEYLE DIDLKTLEKE KLDELGVPLY AVVKEQVKRE NSFRAWNGGF SGNLEGEGFI LQTPASGRS
ALGAAALALL RRPGCFLCRE YGPQRRKMMF KEFGDKVNLL
LANTDVFLSK EAADLSSLKS MGFIRLGVWY SVLEAAKMIK
PQKAALEYLE DIDLKTLEKE MLDQLGVPLY AVVKEHIRTE NFFRAWNGGF SGNLEGEGFI PQTLASEKK
Adrx
Bottom
Adrx
Adpn
AC C
CG
F.
Top
EP
Cnx
GLUT4
D.
TE D
Adrx
CO2H
Day Adrx
0
2
4
6
8
GLUT4
Adpn
E.
229
W AT BA T Lu ng Li ve r Br ai n He ar t M us c St le om a Sm ch al lI nt es Ki dn tin ey e Sp le e Te n st e Pa s nc re as
NH2
TMGMWSIGAG EKNGAVIMAV EIFLDEKKKF KQGILLEHRE
AVGAAAVALL RRPGCFLCRA YGPERRKMMF KEFGDRVNPL
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MSFLQDPSFF PRTFKAKELW VEDFQPYFKG LGGVFVIGSG
SC
1 61 121 181
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A. Mouse Adrx Sequence
Bottom
Top
CG
G.
Adrx Adrx
Porin
Merge
Adrx
Adpn
Merge
Calnexin
Merge
DsbA-L Ero1-α PDIa1 GLUT4
Adrx
ACCEPTED MANUSCRIPT
Figure 2.
-
Adrx
Cell Associated shRNA OE
-
+
Secreted Adiponectin
B.
shRNA
-
+
-
+
IR
Control
shRNA
250
100
*
0.00
150
A.U.
100
LMW
*
Control
shRNA
Control
OE
*
shRNA
**
50 0
100 0
Collagen Secretion
EP
0.50
*
50
MMW
1.50 1.00
*
150
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HMW
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µ g / µ g protein
2.00
*
*
50 0
*
200
A.U.
A.U.
150
LMW
Over Expression
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Control
Insulin Receptor
µ g / µ g protein
250 200
E.
HMW
SC
Actin
D.
+
MMW
Adpn
C.
OE
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A.
1.50
HMW
MMW
LMW
Collagen Secretion *
1.00 0.50 0.00
Control
OE
ACCEPTED MANUSCRIPT
Figure 3. Adrx CFLC
Reduced
PDIa1
Reduced
Adrx SFLS
Reduced
PDIa1
Reduced
Oxidized
Oxidized
Oxidized
Oxidized
l Adrx shRNA
SC
T
T
l ro nt Co a.
Di
DT
ro nt Co a.
Di
DT Control
B..
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A..
Oxidized PDI
Adrx
M AN U
Reduced Oxidized
Reduced
PDIa1
Oxidized
Control
0 0.1 1.0 5.0
H2O2 (mM)
shRNA
*
DTT Dia. 0
H2O2 (mM)
EP a. T
H2O2 (mM)
Di
0.1 1.0 5.0
DT
T
0
a.
Di
DT
AC C
PDIa1
0%
Adrx OE
Adrx
Control
50%
0 0.2 1.0 5.0
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a.
Di
H2O2 (mM)
T
C..
DT
T
a.
Di
DT
0 0.2 1.0 5.0
100%
*
0.2 1.0 5.0
H2O2 (mM)
Oxidized PDI Reduced 100%
Oxidized
50%
Reduced
0%
Oxidized
Control
DTT Dia
Over Expressing
0
0.1 1.0 H2O2 (mM)
5.0
ACCEPTED MANUSCRIPT Figure 4. B.
SC
Component 2 (18.3%)
Collagen
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Secreted
Component 1 (50.6%)
EP
C.
AC C
Component 2 (18.3%)
OE1 OE2 KD1 KD2 CON1 CON2
RI PT
A.
Component 1 (50.6%)
0.2
1
Oxidoreductase Thioredoxin/ Glutathione
4
3
KD/CONT
OE/CONT
2
1
0
Adrx
Adpn
Rtn
SAA
Col1a2 Col3a1 Col6a3
ACCEPTED MANUSCRIPT Figure 5.
***
50 0
WT
D.
Het
0
Bip
Body Weight
300 200
Ero1A
30.0
100
(g)
KO
F.
HMW Adpn
150
(mg/dl)
(ng/ml)
4.0
100
**
2.0 0.0
WT
H.
0
I.
KO
WT
(mg/dl)
400
0
100
150
Collagen Content
120 100 80 60 40 20 0
(%)
50
AC C
J.
EP
200 0
**
WT
WT
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WT
50
KO
IPGTT
600
Fasting Glucose
KO
KO
KO
**
100
0
KO
Bip
**
300
WT
G.
KO
WT
0.4
200
0
WT
*
WT
*
100
0.2 0
KO
Ero1α
Fasting Insulin
(ng/ml)
WT
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0.0
***
WT
0
10.0
Adpn
200
SC
20.0
E.
50
Adpn
KO
300
100
Tubulin
***
Adrx
150 (%)
(%)
100
KO
(%)
Adrx
150
WT
(%)
Adrx mRNA
C.
RI PT
B.
(%)
A.
KO
KO
ACCEPTED MANUSCRIPT Figure 6.
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Females
AC C
C.
EP
TE D
B.
SC
RI PT
A. Males
ACCEPTED MANUSCRIPT
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ER Redox Status
PDI
Adrx
M AN U
SC
Endoplasmic Reticulum lumen
---S-S---
Disulfide bond Formation
Mature Proteins
PM
AC C
EP
TE D
Protein Folding
Adiponectin… Benefical factors
Protein secretion
Collagen/Fibrosis, IR Contributors...
Human/mouse Physiological Metabolic Regulation
ACCEPTED MANUSCRIPT
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• Adrx is an adipocyte specific, endoplasmic reticulum oxidoreductase
SC
upstream of disulfide bond formation.
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• Adrx over and under expression in vitro results enhanced and decreased protein secretion, respectively.
decreased fibrosis.
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• Mice lacking Adrx have lower levels of circulating adiponectin and
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• In humans, mRNA and tissue levels of Adrx and adiponectin protein are positively correlated and elevated adipose inflammation correlates with reduced Adrx protein.
ACCEPTED MANUSCRIPT
n # 600 390 322 285 269 228 216 210 204 200 195 191 186 183 175 175 174 166 161 160 157 156 149 148 133 133 126 120 118 116 115 111 108 106 105 103 102 101 100 100 97 94 93 93 92 91 91 91 87 86 85 84 83 82 82 82 81
of
pe
s CO 42166.9 22153.9 9629.91 14945.6 18994.7 9642 12092.6 12115.9 12416.6 9183.57 9536.64 9887.59 7285.94 10204.8 5943.53 10566.9 8769.35 3308.67 8192.66 9286.89 7573.82 8909.09 8561.17 7755.67 7540.19 6379.82 5700.12 5001.7 6079.87 5564.35 8108.26 4179.54 5011.63 4683.67 5578.89 6810.84 5509.01 5609.74 5130.77 3277.86 5146.53 3403.7 5236.51 4490.02 3505.86 5284.43 5030.46 4681.62 4556.88 3666.2 3315.1 4906.89 4438.89 4642.9 4446.3 5670.47 4212.68
RO NT
L1 CO 51253.2 20992.4 10378 15316.4 15697.5 9855.63 11950.7 10602.4 11167.4 9884.6 8907.74 10775.6 8081.62 7479.45 5081.69 8305.87 8046.16 4165.25 6265.95 10254.3 6450.38 9864.98 7501.87 8426.27 6104.62 6379.82 4769.57 5039.55 5299.87 5383.98 6290.62 3549.26 6220.27 4027.42 6382.25 5084.62 5645.63 4532.73 4633.83 3456.27 4919.55 4449.54 4755.37 4090.71 3650.51 5100.46 4007.31 4345.86 4316.44 4068.6 2820.24 4741.32 4506.18 6524.95 3961.68 6121.95 3609.39
RO NT
L2 o Kn 46822 23079.5 13116.4 15394 15544.3 10781.6 12751.8 16328.7 13596.3 9267.04 10303.8 11912.2 7660.32 12440 10188.8 10374.9 8501.79 4078.65 9492.53 10194.4 8497.49 9787.81 8342.76 9336.26 7596.47 6379.82 7325.14 6352.2 6814.49 6403.52 7809.93 4823.08 10741.1 6422.52 6452.36 5791.43 4355.14 5399.01 6866.51 4263.54 5177.04 5159.04 5994.7 4644.63 4521.82 6714.13 4959.52 4397.97 6384.34 3879.52 4411.69 4181.49 4671.03 6217.39 4600.95 5682.1 6022.09
RI PT
sc De E9Q616_MOUSE Protein Ahnak CH60_MOUSE 60 kDa heat shock protein, mitochondrial G3P_MOUSE Glyceraldehyde-3-phosphate dehydrogenase GRP75_MOUSE Stress-70 protein, mitochondrial FABP4_MOUSE Fatty acid-binding protein, adipocyte PGK1_MOUSE Phosphoglycerate kinase 1 PDIA4_MOUSE Protein disulfide-isomerase A4 ACSL1_MOUSE Long-chain-fatty-acid--CoA ligase 1 ATPB_MOUSE ATP synthase subunit beta, mitochondrial HSP7C_MOUSE Heat shock cognate 71 kDa protein MDHM_MOUSE Malate dehydrogenase, mitochondrial GRP78_MOUSE 78 kDa glucose-regulated protein TPIS_MOUSE Triosephosphate isomerase PYC_MOUSE Pyruvate carboxylase, mitochondrial MYH9_MOUSE Myosin-9 TKT_MOUSE Transketolase ENOA_MOUSE Alpha-enolase FABP5_MOUSE Fatty acid-binding protein, epidermal ACON_MOUSE Aconitate hydratase, mitochondrial PDIA1_MOUSE Protein disulfide-isomerase SPTN1_MOUSE Spectrin alpha chain, non-erythrocytic 1 CALR_MOUSE Calreticulin MMSA_MOUSE Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial PDIA3_MOUSE Protein disulfide-isomerase A3 ENPL_MOUSE Endoplasmin ACTB_MOUSE Actin, cytoplasmic 1 MYH10_MOUSE Myosin-10 EF2_MOUSE Elongation factor 2 FUMH_MOUSE Fumarate hydratase, mitochondrial DYHC1_MOUSE Cytoplasmic dynein 1 heavy chain 1 HS90A_MOUSE Heat shock protein HSP 90-alpha IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic PLIN4_MOUSE Perilipin-4 SYEP_MOUSE Bifunctional glutamate/proline--tRNA ligase NUCL_MOUSE Nucleolin DHE3_MOUSE Glutamate dehydrogenase 1, mitochondrial TERA_MOUSE Transitional endoplasmic reticulum ATPase HS90B_MOUSE Heat shock protein HSP 90-beta SERPH_MOUSE Serpin H1 KPYM_MOUSE Pyruvate kinase PKM 1433B_MOUSE 14-3-3 protein beta/alpha FAS_MOUSE Fatty acid synthase ATPA_MOUSE ATP synthase subunit alpha, mitochondrial 3HIDH_MOUSE 3-hydroxyisobutyrate dehydrogenase, mitochondrial ATP5H_MOUSE ATP synthase subunit d, mitochondrial LDHA_MOUSE L-lactate dehydrogenase A chain ALDH2_MOUSE Aldehyde dehydrogenase, mitochondrial Q3U2G2_MOUSE Heat shock 70 kDa protein 4 VINC_MOUSE Vinculin A6ZI44_MOUSE Fructose-bisphosphate aldolase TLN1_MOUSE Talin-1 KAD2_MOUSE Adenylate kinase 2, mitochondrial TPR_MOUSE Nucleoprotein TPR EF1A1_MOUSE Elongation factor 1-alpha 1 VIGLN_MOUSE Vigilin CH10_MOUSE 10 kDa heat shock protein, mitochondrial SPTB2_MOUSE Spectrin beta chain, non-erythrocytic 1
e id pt
SC
G Ahnak Hspd1 Gapdh Hspa9 Fabp4 Pgk1 Pdia4 Acsl1 Atp5b Hspa8 Mdh2 Hspa5 Tpi1 Pc Myh9 Tkt Eno1 Fabp5 Aco2 P4hb Sptan1 Calr Aldh6a1 Pdia3 Hsp90b1 Actb Myh10 Eef2 Fh Dync1h1 Hsp90aa1 Idh1 Plin4 Eprs Ncl Glud1 Vcp Hsp90ab1 Serpinh1 Pkm Ywhab Fasn Atp5a1 Hibadh Atp5h Ldha Aldh2 Hspa4 Vcl Aldoa Tln1 Ak2 Tpr Eef1a1 Hdlbp Hspe1 Sptbn1
tio rip
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e
l
TE D
en
bo
EP
n ei ot Pr tr|E9Q616|E9Q616_MOUSE sp|P63038|CH60_MOUSE sp|P16858|G3P_MOUSE sp|P38647|GRP75_MOUSE sp|P04117|FABP4_MOUSE sp|P09411|PGK1_MOUSE sp|P08003|PDIA4_MOUSE sp|P41216|ACSL1_MOUSE sp|P56480|ATPB_MOUSE sp|P63017|HSP7C_MOUSE sp|P08249|MDHM_MOUSE sp|P20029|GRP78_MOUSE sp|P17751|TPIS_MOUSE sp|Q05920|PYC_MOUSE sp|Q8VDD5|MYH9_MOUSE sp|P40142|TKT_MOUSE sp|P17182|ENOA_MOUSE sp|Q05816|FABP5_MOUSE sp|Q99KI0|ACON_MOUSE sp|P09103|PDIA1_MOUSE sp|P16546|SPTN1_MOUSE sp|P14211|CALR_MOUSE sp|Q9EQ20|MMSA_MOUSE sp|P27773|PDIA3_MOUSE sp|P08113|ENPL_MOUSE sp|P60710|ACTB_MOUSE sp|Q61879|MYH10_MOUSE sp|P58252|EF2_MOUSE sp|P97807|FUMH_MOUSE sp|Q9JHU4|DYHC1_MOUSE sp|P07901|HS90A_MOUSE sp|O88844|IDHC_MOUSE sp|O88492|PLIN4_MOUSE sp|Q8CGC7|SYEP_MOUSE sp|P09405|NUCL_MOUSE sp|P26443|DHE3_MOUSE sp|Q01853|TERA_MOUSE sp|P11499|HS90B_MOUSE sp|P19324|SERPH_MOUSE sp|P52480|KPYM_MOUSE sp|Q9CQV8|1433B_MOUSE sp|P19096|FAS_MOUSE sp|Q03265|ATPA_MOUSE sp|Q99L13|3HIDH_MOUSE sp|Q9DCX2|ATP5H_MOUSE sp|P06151|LDHA_MOUSE sp|P47738|ALDH2_MOUSE tr|Q3U2G2|Q3U2G2_MOUSE sp|Q64727|VINC_MOUSE tr|A6ZI44|A6ZI44_MOUSE sp|P26039|TLN1_MOUSE sp|Q9WTP6|KAD2_MOUSE sp|F6ZDS4|TPR_MOUSE sp|P10126|EF1A1_MOUSE sp|Q8VDJ3|VIGLN_MOUSE sp|Q64433|CH10_MOUSE sp|Q62261|SPTB2_MOUSE
m Sy
AC C
Id
ck
1 wn do o Kn 40366.8 19009.5 9695.92 13540.2 13396 8199.51 10314.7 13877.9 10204.3 8439.4 8472.97 10398.1 7110.53 9859.08 7664.42 8419.51 7354.13 3608.88 6745.14 8633.95 6682.7 8772.55 7946.9 7477.98 6653.1 6379.82 5685.3 5923.1 5973.96 6845.03 6265.12 3554.9 8312.42 4697.68 6691.33 5674.94 4544.56 4517.3 4866.93 3561.86 4060.61 6605.05 5946.12 3559.26 3343.3 5172.41 4313.82 4466.44 5750.5 3811.5 3353.63 3548 3787.9 8369.58 4176.48 4436.76 4390.29
ck
2 wn do
r ve
O 29382.4 14220.6 21299.5 14407.5 12788.6 26044.5 10376.2 9704.86 7891.6 10315.4 8994.75 10604.2 12237.2 5900.96 15474.8 8897.63 12149.1 13300.5 6977.97 11243.8 7371.56 7833.83 5131.78 6840.56 8362.47 6379.82 6085.78 11586.4 5568.07 7784.97 9334.46 6573.8 4655.88 8754.48 5926.75 5020.99 6402.26 7544.77 4074.6 12419.8 2477.27 7842.94 4565.15 4346.15 2426.67 6436.25 5536 6589.4 5586.56 5376.97 5910.65 5128.39 4197.42 7578.42 3224.65 4573.87 4803.58
e
s re xp
si o
n1 r ve
O 59526.6 26408 16513.5 23857.7 24916.1 27728 14317 11806.4 11100.8 12542.6 12005 12899.8 21618.5 8948.49 8178.31 8871.19 11744 48880.3 10161.9 12554.3 7328.34 13846.2 9421.83 11588.5 6186.6 6379.82 5175.78 8587.55 5531.5 5304.31 5734.48 7992.83 8244.33 5937.63 8725.06 6480.7 7782.03 5376.24 3324.08 8681.19 4517.41 10390.8 4647 10224.3 6222.64 4948.79 9048.01 9198.76 6462.84 6564.73 4693.73 8773.82 5739.39 6046.05 3657.99 10254.6 4411.72
e
s re xp
si o
n2
O /C KD 0.93 0.98 1.14 0.96 0.83 0.97 0.96 1.33 1.01 0.93 1.02 1.08 0.96 1.26 1.62 1.00 0.94 1.03 1.12 0.96 1.08 0.99 1.01 1.04 1.04 1.00 1.24 1.22 1.12 1.21 0.98 1.08 1.70 1.28 1.10 0.96 0.80 0.98 1.20 1.16 0.92 1.50 1.20 0.96 1.10 1.14 1.03 0.98 1.37 0.99 1.27 0.80 0.95 1.31 1.04 0.86 1.33
N
0.95 0.94 1.89 1.26 1.09 2.76 1.03 0.95 0.81 1.20 1.14 1.14 2.20 0.84 2.15 0.94 1.42 8.32 1.19 1.22 1.05 1.15 0.91 1.14 1.07 1.00 1.08 2.01 0.98 1.20 1.05 1.88 1.15 1.69 1.22 0.97 1.27 1.27 0.76 3.13 0.69 2.32 0.92 1.70 1.21 1.10 1.61 1.75 1.36 1.54 1.73 1.44 1.11 1.22 0.82 1.26 1.18
ACCEPTED MANUSCRIPT
3130.47 3887.51 3958.73 2980.36 3754.28 3292.39 5312.56 3303.76 4129.63 2585.93 2378.68 2948.17 4207.31 3881.11 3423.7 3090.97 3706.83 3263.24 4059.93 5138.91 3126 3331.94 2997.83 3588.63 4129.32 5146.5 2947.18 3354.02 4480.28 4699.02 2346.57 3495.6 4396.8 2661.74 2505.39 3575.29 4236.17 1508.17 3525.5 2497.44 3004.13 2726.37 3182.15 2508.7 3485.25 2909.5 1947.65 3296.51 2980.45 2644.85 3232.6 2210.02 2642.17 2512.65 3270.6 2346.98 3068.24 3470.04 2640.72 2722.63 2678.53 3010.02
4383.23 4661.37 4592.61 4155.5 3438.72 5105.64 7934.96 4458.91 4119.78 4199.11 4869.62 3618.5 6197.89 3525.53 4833.44 4202.47 3566.27 4859.57 5189.01 4643.88 4060.77 3554.91 3624.38 4532.07 3501.54 5347.51 5994.9 4218.05 4174.28 4132.67 3667.95 5100.35 4499.52 7007.32 4106.99 3885.05 4135.74 2417.78 2987.23 3360.97 3619.05 4404.29 3349.17 3107.89 3613.98 3596.39 3525.49 5224.53 3742.19 3302.27 4437.17 3271.24 4101.67 3600.44 3934.99 3182.48 2581.03 5243.66 3381.56 4393.59 3990.98 5365.34
TE D
M AN U
SC
RI PT
E9Q6R7_MOUSE Protein Utrn 81 3781.35 Q8R5L1_MOUSE Complement component 1 Q subcomponent-binding protein, mitochondrial 81 3745.98 CALU_MOUSE Calumenin 80 3766.41 UBA1_MOUSE Ubiquitin-like modifier-activating enzyme 1 79 3847.63 ECHM_MOUSE Enoyl-CoA hydratase, mitochondrial 79 4261.46 ECHA_MOUSE Trifunctional enzyme subunit alpha, mitochondrial 77 2988.34 CISY_MOUSE Citrate synthase, mitochondrial 77 5917.6 TRAP1_MOUSE Heat shock protein 75 kDa, mitochondrial 77 4312.22 HNRPQ_MOUSE Heterogeneous nuclear ribonucleoprotein Q 77 4157.09 LETM1_MOUSE LETM1 and EF-hand domain-containing protein 1, mitochondrial 76 3105.96 FLNA_MOUSE Filamin-A 75 2487.89 1433Z_MOUSE 14-3-3 protein zeta/delta 75 3152.18 CYC_MOUSE Cytochrome c, somatic 74 3582.68 PGAM1_MOUSE Phosphoglycerate mutase 1 74 3483.42 OPA1_MOUSE Dynamin-like 120 kDa protein, mitochondrial 74 4497.12 GPDA_MOUSE Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic 73 2953.37 CBR1_MOUSE Carbonyl reductase [NADPH] 1 73 4063.44 G6PI_MOUSE Glucose-6-phosphate isomerase 71 3578 SCOT1_MOUSE Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 71 4634.64 STIP1_MOUSE Stress-induced-phosphoprotein 1 71 3827.32 ACADL_MOUSE Long-chain specific acyl-CoA dehydrogenase, mitochondrial 71 4258.71 1433G_MOUSE 14-3-3 protein gamma 70 3505.48 TCPQ_MOUSE T-complex protein 1 subunit theta 69 3201.15 ACADM_MOUSE Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 69 4862.92 IPYR_MOUSE Inorganic pyrophosphatase 69 3806.85 E9PZ00_MOUSE Sulfated glycoprotein 1 68 5065.96 E9PWQ3_MOUSE Protein Col6a3 67 3880.57 DECR_MOUSE 2,4-dienoyl-CoA reductase, mitochondrial 67 3866.6 ROA2_MOUSE Heterogeneous nuclear ribonucleoproteins A2/B1 67 4860.72 CACP_MOUSE Carnitine O-acetyltransferase 66 5310.83 UGPA_MOUSE UTP--glucose-1-phosphate uridylyltransferase 65 2728.95 EHD2_MOUSE EH domain-containing protein 2 65 4075.57 PRDX1_MOUSE Peroxiredoxin-1 64 4639.53 CO3A1_MOUSE Collagen alpha-1(III) chain 63 5265.8 MAOX_MOUSE NADP-dependent malic enzyme 62 2923.8 MAP4_MOUSE Microtubule-associated protein 4 62 3096.13 RLA2_MOUSE 60S acidic ribosomal protein P2 62 3380.95 FLNB_MOUSE Filamin-B 61 1626.39 CLH1_MOUSE Clathrin heavy chain 1 61 2434.62 VIME_MOUSE Vimentin 61 2588.09 ACBP_MOUSE Acyl-CoA-binding protein 61 2881.76 DNM1L_MOUSE Dynamin-1-like protein 60 3334.29 LEG1_MOUSE Galectin-1 60 2687.78 IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial 60 2820.87 GELS_MOUSE Isoform 2 of Gelsolin 60 3564.3 EFTU_MOUSE Elongation factor Tu, mitochondrial 60 3733.96 PLEC_MOUSE Plectin 59 2384.22 DLDH_MOUSE Dihydrolipoyl dehydrogenase, mitochondrial 59 3638.91 VP13C_MOUSE Vacuolar protein sorting-associated protein 13C 59 3086.22 EF1G_MOUSE Elongation factor 1-gamma 59 2720.5 CATD_MOUSE Cathepsin D 59 3647.15 RRBP1_MOUSE Ribosome-binding protein 1 58 2242.11 MDHC_MOUSE Malate dehydrogenase, cytoplasmic 58 2806 IQGA1_MOUSE Ras GTPase-activating-like protein IQGAP1 58 2856.02 CATA_MOUSE Catalase 58 3572.1 MVP_MOUSE Major vault protein 58 2944.91 ANXA8_MOUSE Annexin A8 58 2957.26 ECHB_MOUSE Trifunctional enzyme subunit beta, mitochondrial 57 2867.45 ODP2_MOUSE Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, 57 mitochondrial 3133.1 MUTA_MOUSE Methylmalonyl-CoA mutase, mitochondrial 56 3482.67 RL5_MOUSE 60S ribosomal protein L5 56 3097.83 BCAT2_MOUSE Branched-chain-amino-acid aminotransferase, mitochondrial 55 3586.44
EP
Utrn C1qbp Calu Uba1 Echs1 Hadha Cs Trap1 Syncrip Letm1 Flna Ywhaz Cycs Pgam1 Opa1 Gpd1 Cbr1 Gpi Oxct1 Stip1 Acadl Ywhag Cct8 Acadm Ppa1 Psap Col6a3 Decr1 Hnrnpa2b1 Crat Ugp2 Ehd2 Prdx1 Col3a1 Me1 Map4 Rplp2 Flnb Cltc Vim Dbi Dnm1l Lgals1 Idh2 Gsn Tufm Plec Dld Vps13c Eef1g Ctsd Rrbp1 Mdh1 Iqgap1 Cat Mvp Anxa8 Hadhb Dlat Mut Rpl5 Bcat2
AC C
tr|E9Q6R7|E9Q6R7_MOUSE tr|Q8R5L1|Q8R5L1_MOUSE sp|O35887|CALU_MOUSE sp|Q02053|UBA1_MOUSE sp|Q8BH95|ECHM_MOUSE sp|Q8BMS1|ECHA_MOUSE sp|Q9CZU6|CISY_MOUSE sp|Q9CQN1|TRAP1_MOUSE sp|Q7TMK9|HNRPQ_MOUSE sp|Q9Z2I0|LETM1_MOUSE sp|Q8BTM8|FLNA_MOUSE sp|P63101|1433Z_MOUSE sp|P62897|CYC_MOUSE sp|Q9DBJ1|PGAM1_MOUSE sp|P58281|OPA1_MOUSE sp|P13707|GPDA_MOUSE sp|P48758|CBR1_MOUSE sp|P06745|G6PI_MOUSE sp|Q9D0K2|SCOT1_MOUSE sp|Q60864|STIP1_MOUSE sp|P51174|ACADL_MOUSE sp|P61982|1433G_MOUSE sp|P42932|TCPQ_MOUSE sp|P45952|ACADM_MOUSE sp|Q9D819|IPYR_MOUSE tr|E9PZ00|E9PZ00_MOUSE tr|E9PWQ3|E9PWQ3_MOUSE sp|Q9CQ62|DECR_MOUSE sp|O88569|ROA2_MOUSE sp|P47934|CACP_MOUSE sp|Q91ZJ5|UGPA_MOUSE sp|Q8BH64|EHD2_MOUSE sp|P35700|PRDX1_MOUSE sp|P08121|CO3A1_MOUSE sp|P06801|MAOX_MOUSE sp|P27546|MAP4_MOUSE sp|P99027|RLA2_MOUSE sp|Q80X90|FLNB_MOUSE sp|Q68FD5|CLH1_MOUSE sp|P20152|VIME_MOUSE sp|P31786|ACBP_MOUSE sp|Q8K1M6|DNM1L_MOUSE sp|P16045|LEG1_MOUSE sp|P54071|IDHP_MOUSE sp|P13020-2|GELS_MOUSE sp|Q8BFR5|EFTU_MOUSE sp|Q9QXS1|PLEC_MOUSE sp|O08749|DLDH_MOUSE sp|Q8BX70|VP13C_MOUSE sp|Q9D8N0|EF1G_MOUSE sp|P18242|CATD_MOUSE sp|Q99PL5|RRBP1_MOUSE sp|P14152|MDHC_MOUSE sp|Q9JKF1|IQGA1_MOUSE sp|P24270|CATA_MOUSE sp|Q9EQK5|MVP_MOUSE sp|O35640|ANXA8_MOUSE sp|Q99JY0|ECHB_MOUSE sp|Q8BMF4|ODP2_MOUSE sp|P16332|MUTA_MOUSE sp|P47962|RL5_MOUSE sp|O35855|BCAT2_MOUSE
3068.53 3524.62 3278.04 3299.21 3492.17 3626.48 5845.3 3710.41 3556.92 3158.52 3765.83 2905.66 3353.95 4463.9 3465.6 4096.4 2521.87 3453.13 4842.3 5557.17 3270.84 2665.53 3073.39 3901.89 2701.25 4653.84 4240.24 3187.41 3644.31 4522.04 2801.92 4119.46 3859.82 3024.41 3830.9 3442.32 3619.73 1876.17 4479.59 2470.95 2922.27 3189.11 3260.5 2263.41 3268.96 2805.13 2419.71 4166.84 4041.49 3355.84 3896.27 3044.62 3457.8 2792.64 3431.78 2479.84 2573.38 3477.8 2750.89 3661.88 3006.08 4211.7
3637.71 3031.18 2690.65 4560.04 3096.97 4742.21 5437.83 2223.34 3008.24 2785.35 4710.34 4604.36 3903.45 5077.21 3147.18 3787.23 5762.43 5623.71 3972.44 5858.58 2498.42 3129.55 4733.87 1830.64 6087.36 3213.21 2092.82 3821.04 2761.01 3147.62 4066.37 3024.49 4533.38 1124.7 2581.99 2129.68 2905.11 5014.93 5542.5 2484.7 1380.17 3959.47 2510.09 4908.19 2658.33 2416.89 5533.21 2784.01 2758.03 4635.22 1750.59 2770.53 2242.72 4552.15 2530.63 2063.28 4091.11 2682.43 2188.69 1736 3344.51 2878.33
3968.32 6450.02 5015.24 3631.08 5218.82 9974.06 4847.29 3227.36 4921.16 3978.21 4875.35 5117.46 5773.29 5663.91 3384.33 5877.37 8494.19 3135.5 5322.21 8526.45 3990.54 4474.41 3250.9 3739.82 14545 7347.1 1826.31 4999.14 6564.14 4246.57 3537.3 4034.91 10678.3 1225.07 3088.07 2371 6405.32 3194.32 4197.94 7687.18 4788.59 3263.45 6531.33 4726.43 4034.89 5199.73 4186.88 3470.84 2607.23 3059.87 2999.61 5081.21 2631.43 2514.51 4146.46 2656.46 3072.68 6139.47 3246.54 2463.43 2406.49 4218.58
1.08 1.07 1.02 1.09 0.86 1.39 1.23 1.07 0.93 1.29 1.77 1.07 1.23 1.08 1.05 1.37 0.78 1.22 1.15 1.14 0.99 0.91 1.08 1.00 0.78 0.98 1.50 1.03 0.84 0.86 1.27 1.22 0.93 1.27 1.46 1.10 1.02 1.37 1.25 1.15 1.11 1.25 1.13 1.01 0.98 0.96 1.37 1.35 1.28 1.24 1.21 1.42 1.39 1.19 1.08 1.07 0.86 1.38 1.06 1.30 1.21 1.45
1.10 1.24 1.00 1.20 1.04 2.34 0.92 0.72 0.96 1.19 1.97 1.59 1.24 1.46 0.82 1.60 1.83 1.28 1.07 1.60 0.88 1.11 1.29 0.66 2.60 1.03 0.57 1.22 1.00 0.74 1.50 0.93 1.68 0.30 1.04 0.67 1.22 2.62 1.63 2.00 1.05 1.19 1.54 1.81 0.95 1.15 2.24 0.90 0.88 1.43 0.69 1.76 0.89 1.32 0.98 0.89 1.19 1.39 0.94 0.68 1.00 1.08
ACCEPTED MANUSCRIPT
2820.64 2674.86 2404.85 3987.21 2895.93 3396.89 3715.38 3710.16 2416.11 2716.69 4249.6 1583.94 1833.78 2472.21 2248.42 2459.53 1921.33 2583.85 2304.38 2093.03 2878.77 2896.84 2519.21 2384.85 3042.17 2261.48 2737.34 2522.97 3835.72 2478.09 2476.75 2552.61 2172.67 2540.85 2491.28 2447.27 2893.12 4530.04 3108.68 2470.15 2661 1644.35 1647.54 2234.47 2651.04 3074.53 2413.9 2449.7 2141.35 2776.37 2817.14 2180.86 2329.65 1490.88 2698.73 2813.23 1680.37 1701.81 1570.69 1677.73 3045.94 3497.85
3566.38 4512.6 3233.69 3290.35 3304.6 3761.56 3785.22 2807.27 4099.55 2767.32 3228.98 2032.18 2497.8 2806.14 2910.66 3138.7 3424.24 3082.7 2352.26 3659.91 3358.87 3331.88 2521.25 2552.24 3382.01 3269.71 3595.63 2862.24 3667.45 3193.11 3104.84 3155.17 2899.05 2859.28 2143.36 2273.81 3416.9 3158.65 4059.12 2992.23 3217.73 2373.23 2576.27 2230.58 3308.3 3512.66 1899.53 3084.99 2448.89 3264.87 3950.13 2540.43 2523.02 1904.89 2786.03 2415.03 2473.67 2305.56 2178.71 2109.69 3353.57 3327.08
TE D
M AN U
SC
RI PT
ATPG_MOUSE ATP synthase subunit gamma, mitochondrial 55 3250.76 ODB2_MOUSE Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase 55 complex, mitochondrial 3420.1 E9PVZ8_MOUSE Protein Golgb1 55 2514.73 COF1_MOUSE Cofilin-1 55 2723.29 TCPB_MOUSE T-complex protein 1 subunit beta 55 3252.38 NCPR_MOUSE NADPH--cytochrome P450 reductase 55 3823.56 PTRF_MOUSE Polymerase I and transcript release factor 55 3378.93 PABP1_MOUSE Polyadenylate-binding protein 1 55 3050.09 PGM1_MOUSE Phosphoglucomutase-1 54 2756.37 RS3A_MOUSE 40S ribosomal protein S3a 54 2957.49 ANXA6_MOUSE Annexin A6 54 4496.37 THIM_MOUSE 3-ketoacyl-CoA thiolase, mitochondrial 53 1463.79 AMPL_MOUSE Cytosol aminopeptidase 53 1850.57 DDB1_MOUSE DNA damage-binding protein 1 53 2586.06 HYOU1_MOUSE Hypoxia up-regulated protein 1 53 2468.59 ANXA1_MOUSE Annexin A1 53 2699.53 NAMPT_MOUSE Nicotinamide phosphoribosyltransferase 52 2160.29 TCPE_MOUSE T-complex protein 1 subunit epsilon 52 2827.78 PRS6A_MOUSE 26S protease regulatory subunit 6A 52 2324.12 AIFM1_MOUSE Apoptosis-inducing factor 1, mitochondrial 51 2517.75 RS27A_MOUSE Ubiquitin-40S ribosomal protein S27a 51 2890.9 SDHB_MOUSE Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 51 2976.94 ETFA_MOUSE Electron transfer flavoprotein subunit alpha, mitochondrial 51 2635.41 HNRPU_MOUSE Heterogeneous nuclear ribonucleoprotein U 51 3014.06 CO3_MOUSE Complement C3 50 2596.18 IMMT_MOUSE Mitochondrial inner membrane protein 50 2885.76 ACOC_MOUSE Cytoplasmic aconitate hydratase 50 3114.19 PPIA_MOUSE Peptidyl-prolyl cis-trans isomerase A 50 2306.7 PRDX5_MOUSE Peroxiredoxin-5, mitochondrial 50 3814.52 ACACA_MOUSE Acetyl-CoA carboxylase 1 49 2309.28 SYYC_MOUSE Tyrosine--tRNA ligase, cytoplasmic 49 2868.65 SDHA_MOUSE Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 49 3138.93 LONM_MOUSE Lon protease homolog, mitochondrial 49 2583.14 LAMB1_MOUSE Laminin subunit beta-1 49 2639.15 EF1B_MOUSE Elongation factor 1-beta 49 2083.17 TBA1B_MOUSE Tubulin alpha-1B chain 49 2569.09 SAHH_MOUSE Adenosylhomocysteinase 49 4016.74 GRPE1_MOUSE GrpE protein homolog 1, mitochondrial 49 2594.88 AL1A7_MOUSE Aldehyde dehydrogenase, cytosolic 1 48 3547.33 NLTP_MOUSE Non-specific lipid-transfer protein 47 2285.01 NDUS1_MOUSE NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial 47 3613.59 MOES_MOUSE Moesin 46 1652.43 PSA_MOUSE Puromycin-sensitive aminopeptidase 46 2094.89 HSP72_MOUSE Heat shock-related 70 kDa protein 2 46 1999.23 ALDR_MOUSE Aldose reductase 46 3253.47 CPT2_MOUSE Carnitine O-palmitoyltransferase 2, mitochondrial 46 3534.22 FLNC_MOUSE Filamin-C 46 2359.76 SYIC_MOUSE Isoleucine--tRNA ligase, cytoplasmic 45 2435.12 CAND1_MOUSE Cullin-associated NEDD8-dissociated protein 1 45 1879.88 RLA0_MOUSE 60S acidic ribosomal protein P0 45 2598.47 ETFB_MOUSE Electron transfer flavoprotein subunit beta 45 2880.53 E9PZF0_MOUSE Nucleoside diphosphate kinase 45 2243.55 GDIB_MOUSE Rab GDP dissociation inhibitor beta 45 2711.23 VDAC1_MOUSE Voltage-dependent anion-selective channel protein 1 45 2073.43 ODPX_MOUSE Pyruvate dehydrogenase protein X component, mitochondrial 45 2853.32 GDIA_MOUSE Rab GDP dissociation inhibitor alpha 45 3399.97 LPPRC_MOUSE Leucine-rich PPR motif-containing protein, mitochondrial 44 1312.82 SUCB1_MOUSE Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial 44 1816 SYAC_MOUSE Alanine--tRNA ligase, cytoplasmic 44 1779.26 TCPA_MOUSE T-complex protein 1 subunit alpha 44 2033.34 IVD_MOUSE Isovaleryl-CoA dehydrogenase, mitochondrial 44 3536.5 RL17_MOUSE 60S ribosomal protein L17 44 3280.21
EP
Atp5c1 Dbt Golgb1 Cfl1 Cct2 Por Ptrf Pabpc1 Pgm1 Rps3a Anxa6 Acaa2 Lap3 Ddb1 Hyou1 Anxa1 Nampt Cct5 Psmc3 Aifm1 Rps27a Sdhb Etfa Hnrnpu C3 Immt Aco1 Ppia Prdx5 Acaca Yars Sdha Lonp1 Lamb1 Eef1b Tuba1b Ahcy Grpel1 Aldh1a7 Scp2 Ndufs1 Msn Npepps Hspa2 Akr1b1 Cpt2 Flnc Iars Cand1 Rplp0 Etfb Gm20390 Gdi2 Vdac1 Pdhx Gdi1 Lrpprc Sucla2 Aars Tcp1 Ivd Rpl17
AC C
sp|Q91VR2|ATPG_MOUSE sp|P53395|ODB2_MOUSE tr|E9PVZ8|E9PVZ8_MOUSE sp|P18760|COF1_MOUSE sp|P80314|TCPB_MOUSE sp|P37040|NCPR_MOUSE sp|O54724|PTRF_MOUSE sp|P29341|PABP1_MOUSE sp|Q9D0F9|PGM1_MOUSE sp|P97351|RS3A_MOUSE sp|P14824|ANXA6_MOUSE sp|Q8BWT1|THIM_MOUSE sp|Q9CPY7|AMPL_MOUSE sp|Q3U1J4|DDB1_MOUSE sp|Q9JKR6|HYOU1_MOUSE sp|P10107|ANXA1_MOUSE sp|Q99KQ4|NAMPT_MOUSE sp|P80316|TCPE_MOUSE sp|O88685|PRS6A_MOUSE sp|Q9Z0X1|AIFM1_MOUSE sp|P62983|RS27A_MOUSE sp|Q9CQA3|SDHB_MOUSE sp|Q99LC5|ETFA_MOUSE sp|Q8VEK3|HNRPU_MOUSE sp|P01027|CO3_MOUSE sp|Q8CAQ8|IMMT_MOUSE sp|P28271|ACOC_MOUSE sp|P17742|PPIA_MOUSE sp|P99029|PRDX5_MOUSE sp|Q5SWU9|ACACA_MOUSE sp|Q91WQ3|SYYC_MOUSE sp|Q8K2B3|SDHA_MOUSE sp|Q8CGK3|LONM_MOUSE sp|P02469|LAMB1_MOUSE sp|O70251|EF1B_MOUSE sp|P05213|TBA1B_MOUSE sp|P50247|SAHH_MOUSE sp|Q99LP6|GRPE1_MOUSE sp|O35945|AL1A7_MOUSE sp|P32020|NLTP_MOUSE sp|Q91VD9|NDUS1_MOUSE sp|P26041|MOES_MOUSE sp|Q11011|PSA_MOUSE sp|P17156|HSP72_MOUSE sp|P45376|ALDR_MOUSE sp|P52825|CPT2_MOUSE sp|Q8VHX6|FLNC_MOUSE sp|Q8BU30|SYIC_MOUSE sp|Q6ZQ38|CAND1_MOUSE sp|P14869|RLA0_MOUSE sp|Q9DCW4|ETFB_MOUSE tr|E9PZF0|E9PZF0_MOUSE sp|Q61598|GDIB_MOUSE sp|Q60932|VDAC1_MOUSE sp|Q8BKZ9|ODPX_MOUSE sp|P50396|GDIA_MOUSE sp|Q6PB66|LPPRC_MOUSE sp|Q9Z2I9|SUCB1_MOUSE sp|Q8BGQ7|SYAC_MOUSE sp|P11983|TCPA_MOUSE sp|Q9JHI5|IVD_MOUSE sp|Q9CPR4|RL17_MOUSE
4299.81 3123.87 2408.35 3525.94 2713.72 3265.73 2933.15 3115.71 2894.94 2646.01 2551.98 1655.64 1859.35 2809.12 2239.62 2198.63 2534.75 2565.5 1973.98 2709.35 2822.46 2658.51 2470.3 2190.07 3740.24 2682.42 3131.55 2369.02 2973.51 3696.8 2659.65 2783.81 1996.71 2334.23 2432.31 2682.43 3150.76 3054.18 3710.1 2739.47 2611.08 1801.97 1878.49 2312.4 2715.78 2914.27 1558.77 3007.31 2560.38 2977.55 2509.76 2155.91 2676.84 1440.31 2332.33 2355.99 2320.85 2134.59 1982.88 1783.94 3228.43 3007.72
2502.9 2484.96 2914.93 5219.73 3481.87 4127.84 2142.68 2806.24 3006.87 3795.85 4875.53 4602.65 3263.64 2572.62 2520.33 4017.7 3726.28 3806.12 2389.87 2390.22 3596.64 2593.47 2206.72 4370.67 1288.32 5561.55 4006.87 1861.24 2878.07 2049.61 3952.23 2948.35 2587.09 1739.72 2755.98 4806.38 4127.16 3574.17 3575.11 4370.99 2869.94 2297.82 2222 2360.74 3362.47 1654.5 5107.08 4316.95 4463.7 3599.33 3256.69 2279.54 2772.33 7070.54 1591.12 2818.1 3341.6 3225.96 1713.16 3565.49 2647.54 2620.44
2697.45 3440.13 4527 9752.23 3086.21 5128.46 4174.71 5030.87 2106.04 5233.42 2671.4 8486.3 3690.83 2089.58 3247.84 450.645 3462.46 3653.91 4109.42 2005.4 7863.39 3823.7 4770.68 3225.66 2478.61 4369.94 2912.35 4141.88 5658.26 2605.13 3087.93 2681.99 3081.28 2413.24 6916.9 4977.27 3643.42 6133.17 3824.48 6331.14 3556.13 1752.91 1573.07 3223.08 4694.41 2715.26 4756.41 2753.79 2736.44 3387.17 6435.75 3141.46 2238.29 2027.09 3774.12 2427.84 3511.43 5129.33 2314.65 2629.59 3905.92 5216.91
1.30 1.25 1.15 1.02 0.98 0.97 0.95 0.88 1.35 0.95 0.66 1.21 1.18 1.11 1.09 1.03 1.46 1.04 0.93 1.38 1.07 1.02 0.97 0.88 1.26 1.16 1.15 1.08 0.87 1.44 1.08 1.04 1.03 1.00 1.00 0.99 0.95 0.87 1.17 1.21 0.93 1.27 1.19 1.07 1.02 0.97 0.72 1.25 1.25 1.16 1.13 1.06 1.03 0.94 0.92 0.77 1.60 1.26 1.24 1.05 1.00 0.93
0.86 0.97 1.51 2.23 1.07 1.28 0.89 1.16 0.99 1.59 0.86 4.29 1.89 0.92 1.22 0.87 1.76 1.38 1.40 0.95 1.99 1.09 1.35 1.41 0.67 1.93 1.18 1.24 1.12 0.97 1.32 0.99 1.19 0.80 2.11 1.95 1.12 1.36 1.11 2.25 1.02 1.23 1.01 1.32 1.36 0.66 2.07 1.45 1.79 1.30 1.70 1.23 0.99 2.55 0.97 0.84 2.29 2.38 1.20 1.67 1.00 1.16
ACCEPTED MANUSCRIPT
2415.73 1395.44 2990.06 1659.43 1634.6 1711.29 2018.69 1816.15 2824.65 2487.01 2115.29 2681.77 1503.07 2159.22 1975.03 1582.24 2016.5 2098.7 2577.08 2280.47 2480.89 2318.69 3335.4 1769.63 1580.2 1630.4 2114.52 2388.02 2039.35 2587.09 1477.83 1679.63 1297.32 1884.2 1873.74 2155.58 2727.43 1652.35 1643.34 1680.18 1999.95 2630.98 1666.19 1279.04 1275.67 2575.82 1587.3 2502.47 2199.34 2184.61 1823.64 1833.51 1414.34 2188.24 2081.95 2286.35 1552.99 1962.12 1487.34 1682.7 2860.35 1886.27
2145.55 2404.08 4218.63 2207.07 2210.05 2779.67 2733.78 2515.52 3045.44 2309.28 2203.28 2421.7 2495.95 3047.38 2284.83 2041.23 2402.93 2591.48 3002.66 2866.24 2516.23 2284.43 3136.91 2236.27 2275.36 2389.59 2302.82 2611.07 2198.48 2654.46 1825.12 2009.88 1544.33 1695.14 2075.95 2091.77 3472.79 2407.07 2261.72 2495.75 2533.46 2753.13 1802.28 1252.33 1255.69 2410.88 2388.81 3709.08 2837.28 3026.65 2245.76 2187.83 1821.83 2771.98 2254.13 2354.88 1558.98 1926.9 2153.56 2382.81 2400.69 2095.16
TE D
M AN U
SC
RI PT
LMNA_MOUSE Prelamin-A/C 44 2886.24 AL4A1_MOUSE Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 43 1790.84 OLA1_MOUSE Obg-like ATPase 1 43 2619.4 TCPD_MOUSE T-complex protein 1 subunit delta 43 1698.87 TXND5_MOUSE Thioredoxin domain-containing protein 5 43 1569.33 PYGB_MOUSE Glycogen phosphorylase, brain form 43 1987.85 Q3V117_MOUSE ATP-citrate synthase 43 2208.17 ACTN4_MOUSE Alpha-actinin-4 43 2054.38 CALX_MOUSE Calnexin 43 2397.29 PROF1_MOUSE Profilin-1 43 2380.65 SODM_MOUSE Superoxide dismutase [Mn], mitochondrial 43 2306.33 P4HA1_MOUSE Isoform 2 of Prolyl 4-hydroxylase subunit alpha-1 43 2592.52 C1TC_MOUSE C-1-tetrahydrofolate synthase, cytoplasmic 42 1845.46 LDHB_MOUSE L-lactate dehydrogenase B chain 42 2433.05 RL3_MOUSE 60S ribosomal protein L3 42 2042.43 SUCB2_MOUSE Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial 42 1729.94 PDIA6_MOUSE Protein disulfide-isomerase A6 42 2132.37 EIF3A_MOUSE Eukaryotic translation initiation factor 3 subunit A 42 2363.72 SERC_MOUSE Phosphoserine aminotransferase 42 2898.59 ACADS_MOUSE Short-chain specific acyl-CoA dehydrogenase, mitochondrial 42 2846.99 CNDP2_MOUSE Cytosolic non-specific dipeptidase 42 2722.95 DHPR_MOUSE Dihydropteridine reductase 42 2648.73 HMGB1_MOUSE High mobility group protein B1 42 3338.82 AT2A2_MOUSE Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 41 1762.82 HIBCH_MOUSE 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 41 1653.93 ASNS_MOUSE Asparagine synthetase [glutamine-hydrolyzing] 41 1843.32 XDH_MOUSE Xanthine dehydrogenase/oxidase 41 2389.72 TALDO_MOUSE Transaldolase 41 2712.5 ODO2_MOUSE Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase 41 complex, 2261.54 mitochondrial SODC_MOUSE Superoxide dismutase [Cu-Zn] 41 2519.01 MPCP_MOUSE Phosphate carrier protein, mitochondrial 40 1681.97 1433T_MOUSE 14-3-3 protein theta 40 1838.27 IDH3A_MOUSE Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 40 1517.44 NPM_MOUSE Nucleophosmin 40 1619.3 ROA3_MOUSE Heterogeneous nuclear ribonucleoprotein A3 40 1917.87 EEA1_MOUSE Early endosome antigen 1 40 1987.3 BAP31_MOUSE B-cell receptor-associated protein 31 39 2252.49 QCR2_MOUSE Cytochrome b-c1 complex subunit 2, mitochondrial 39 1725.2 SYLC_MOUSE Leucine--tRNA ligase, cytoplasmic 39 1571.94 CD36_MOUSE Platelet glycoprotein 4 39 1871.49 PHB_MOUSE Prohibitin 39 2019.28 HCDH_MOUSE Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 39 2533.08 TBB4B_MOUSE Tubulin beta-4B chain 39 1513.56 PARK7_MOUSE Protein DJ-1 39 1159.38 GCSH_MOUSE Glycine cleavage system H protein, mitochondrial 39 1205.31 1433E_MOUSE 14-3-3 protein epsilon 39 2654.65 AATM_MOUSE Aspartate aminotransferase, mitochondrial 38 1385.2 NNTM_MOUSE NAD(P) transhydrogenase, mitochondrial 38 2788.89 RS2_MOUSE 40S ribosomal protein S2 38 2270.25 RL7_MOUSE 60S ribosomal protein L7 38 2578.81 TCPZ_MOUSE T-complex protein 1 subunit zeta 38 1971.53 MYL6_MOUSE Myosin light polypeptide 6 38 1668.05 IF2P_MOUSE Eukaryotic translation initiation factor 5B 38 1675.43 PDC6I_MOUSE Programmed cell death 6-interacting protein 38 2482.73 SDPR_MOUSE Serum deprivation-response protein 38 1922.53 ROAA_MOUSE Heterogeneous nuclear ribonucleoprotein A/B 38 2039.47 OAT_MOUSE Ornithine aminotransferase, mitochondrial 38 1539.04 PRS4_MOUSE 26S protease regulatory subunit 4 38 2002.73 RPN1_MOUSE Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 37 1768.39 KTN1_MOUSE Isoform 13 of Kinectin 37 1862 TCTP_MOUSE Translationally-controlled tumor protein 37 1766.42 PSD12_MOUSE 26S proteasome non-ATPase regulatory subunit 12 37 1930.24
EP
Lmna Aldh4a1 Ola1 Cct4 Txndc5 Pygb Acly Actn4 Canx Pfn1 Sod2 P4ha1 Mthfd1 Ldhb Rpl3 Suclg2 Pdia6 Eif3a Psat1 Acads Cndp2 Qdpr Hmgb1 Atp2a2 Hibch Asns Xdh Taldo1 Dlst Sod1 Slc25a3 Ywhaq Idh3a Npm1 Hnrnpa3 Eea1 Bcap31 Uqcrc2 Lars Cd36 Phb Hadh Tubb4b Park7 Gcsh Ywhae Got2 Nnt Rps2 Rpl7 Cct6a Myl6 Eif5b Pdcd6ip Sdpr Hnrnpab Oat Psmc1 Rpn1 Ktn1 Tpt1 Psmd12
AC C
sp|P48678|LMNA_MOUSE sp|Q8CHT0|AL4A1_MOUSE sp|Q9CZ30|OLA1_MOUSE sp|P80315|TCPD_MOUSE sp|Q91W90|TXND5_MOUSE sp|Q8CI94|PYGB_MOUSE tr|Q3V117|Q3V117_MOUSE sp|P57780|ACTN4_MOUSE sp|P35564|CALX_MOUSE sp|P62962|PROF1_MOUSE sp|P09671|SODM_MOUSE sp|Q60715-2|P4HA1_MOUSE sp|Q922D8|C1TC_MOUSE sp|P16125|LDHB_MOUSE sp|P27659|RL3_MOUSE sp|Q9Z2I8|SUCB2_MOUSE sp|Q922R8|PDIA6_MOUSE sp|P23116|EIF3A_MOUSE sp|Q99K85|SERC_MOUSE sp|Q07417|ACADS_MOUSE sp|Q9D1A2|CNDP2_MOUSE sp|Q8BVI4|DHPR_MOUSE sp|P63158|HMGB1_MOUSE sp|O55143|AT2A2_MOUSE sp|Q8QZS1|HIBCH_MOUSE sp|Q61024|ASNS_MOUSE sp|Q00519|XDH_MOUSE sp|Q93092|TALDO_MOUSE sp|Q9D2G2|ODO2_MOUSE sp|P08228|SODC_MOUSE sp|Q8VEM8|MPCP_MOUSE sp|P68254|1433T_MOUSE sp|Q9D6R2|IDH3A_MOUSE sp|Q61937|NPM_MOUSE sp|Q8BG05|ROA3_MOUSE sp|Q8BL66|EEA1_MOUSE sp|Q61335|BAP31_MOUSE sp|Q9DB77|QCR2_MOUSE sp|Q8BMJ2|SYLC_MOUSE sp|Q08857|CD36_MOUSE sp|P67778|PHB_MOUSE sp|Q61425|HCDH_MOUSE sp|P68372|TBB4B_MOUSE sp|Q99LX0|PARK7_MOUSE sp|Q91WK5|GCSH_MOUSE sp|P62259|1433E_MOUSE sp|P05202|AATM_MOUSE sp|Q61941|NNTM_MOUSE sp|P25444|RS2_MOUSE sp|P14148|RL7_MOUSE sp|P80317|TCPZ_MOUSE sp|Q60605|MYL6_MOUSE sp|Q05D44|IF2P_MOUSE sp|Q9WU78|PDC6I_MOUSE sp|Q63918|SDPR_MOUSE sp|Q99020|ROAA_MOUSE sp|P29758|OAT_MOUSE sp|P62192|PRS4_MOUSE sp|Q91YQ5|RPN1_MOUSE sp|Q61595-13|KTN1_MOUSE sp|P63028|TCTP_MOUSE sp|Q9D8W5|PSD12_MOUSE
1917.7 1867.58 2862.32 2022.89 1761.15 1764.08 2284.25 1879.88 2545.38 2613.67 1918.33 2094.52 1955.38 2722.35 2170.96 1611.94 2124.04 2161.05 2389.81 2107.1 2032.55 1876.98 2198.91 2237.5 1793.81 1866.43 2162.55 2387.12 1742.78 2010.32 2076.16 1654.97 1206.17 1712.92 1600.99 1827.81 4110.2 2059.16 1927.15 1867.16 2310.2 3146.84 1652.7 1190.49 1109.14 2229.92 1757 3195.01 2562.03 2569.3 2140.7 1713.41 1547.02 2152.37 1868.99 2025.74 1417.31 1791.77 1866.27 1904.35 2955.25 2264.81
1982.1 1278.58 3760.85 3716.14 1339.35 2839.28 2251.24 2851.22 2899.72 3551.66 2615.89 2161.25 3862.34 2706.5 2360.25 1776.45 1762.55 2461.31 2781.02 1654.53 1318.03 2336.07 3244.96 3648.75 3245.88 2928.43 2430.26 2590.59 2051.74 1403.19 3288.1 2457.85 2361.03 2592.49 1472.35 2024.49 3181.54 1831.09 4253.72 1606.33 2576.54 2866.94 3665.33 1904.64 1247.05 2882.95 3753.77 2909.23 3323.13 2365.76 2750.31 2009.47 1782.2 2675.33 1227.67 1401.1 1955.76 2047.59 2823.5 2249.57 2441.33 3121.59
2204.8 1626.26 4132.56 2665.68 2389.32 1601.43 2108.32 2195.36 2542.13 5200.51 5039.2 1892.87 3162.23 2219.59 1566.31 3008.54 2312.77 2470.43 1906.03 2472.27 2166.37 2975.43 6042.06 2491.16 4008.44 2419.16 1856.38 2797.45 2855.99 5071.41 2590.02 2998.17 4694.49 4074.98 2804.14 3479.81 2719.21 1430.68 2390.25 1346.46 2537.6 3623.75 4502.87 4056.09 3119.24 3043.92 1696.3 1842.71 2417.31 2139.01 2353.27 4441.03 2088.09 2415.58 2865.52 3869.56 1942.15 2750.45 2062.15 4156.29 5900.63 2174.95
0.77 1.34 1.26 1.26 1.24 1.23 1.19 1.14 1.07 1.01 0.93 0.86 1.33 1.26 1.11 1.10 1.09 1.07 0.98 0.97 0.87 0.84 0.80 1.27 1.26 1.23 0.99 0.98 0.92 0.91 1.23 1.04 0.98 0.97 0.97 0.95 1.52 1.32 1.30 1.23 1.21 1.14 1.09 1.00 0.95 0.89 1.39 1.30 1.21 1.17 1.16 1.11 1.09 1.05 1.03 1.01 0.96 0.94 1.23 1.21 1.16 1.14
0.79 0.91 1.41 1.90 1.16 1.20 1.03 1.30 1.04 1.80 1.73 0.77 2.10 1.07 0.98 1.44 0.98 1.11 0.86 0.80 0.67 1.07 1.39 1.74 2.24 1.54 0.95 1.06 1.14 1.27 1.86 1.55 2.51 1.90 1.13 1.33 1.18 0.97 2.07 0.83 1.27 1.26 2.57 2.44 1.76 1.13 1.83 0.90 1.28 0.95 1.34 1.84 1.25 1.09 1.02 1.22 1.26 1.21 1.50 1.81 1.80 1.39
ACCEPTED MANUSCRIPT
1654.38 1593.05 2739.27 1404.24 2365.51 1794.31 2037.81 1437.71 1952.65 2308.17 2190.74 2095.48 2227 1002.08 1200.09 1623.57 1817.79 1751.53 3399.98 2302.13 1980.05 1702.41 1709.63 1440.02 1436.39 1930.47 2294.6 1464.68 1496.72 2296.06 1631.42 1486.15 1512.59 1079.08 1185.97 1413.52 2014.34 1532.24 1503.51 1531.34 1821.3 1574.88 1716.33 1758.94 2206.13 1560.82 1951.82 1018.07 1261.27 1688.19 1594.44 1699.04 1327.33 1537.87 1795.29 1725.61 1951.18 722.986 1338.65 714.647 1145.54 1634.65
2475.39 2553.82 2970.86 1789.16 2221 1955.11 2086.24 2126.42 2428.05 2265.58 2786.83 2165.42 2113.42 1617.01 1469.01 2016.36 1682.38 1956.99 3059.14 2202.25 1973.32 3188.81 2103.38 1791.9 1822.58 2512.46 2870.44 1732.85 1594.31 1875.98 2506.01 2186.83 2135.26 1494.87 1276.53 1763.06 2665.82 2222.77 1984.4 1813.4 1964.83 1686.49 1571.46 1951.94 2114.54 1810.92 1803.07 1421.66 1585.75 1852.25 1867.98 1798.76 1738.91 1654.84 1711.74 1682.96 1696.49 2612.81 1751.05 852.833 1367.63 1938.53
RI PT
2035.53 2113.13 2596.52 1761.32 2070.48 1628.6 2168.88 1625.45 1983.01 1720.05 2213.13 2268.37 2514.15 1073.47 1248.93 1807.82 1493.07 2207.4 2647.63 2270.23 2205.87 1137.54 1820.32 1227.89 1566.15 2525.77 2702.97 1900.94 1545.85 1903.46 1976.78 1685.08 1693.32 1240.63 1100.96 1418.24 2356.17 2045.47 1972.06 1729.65 2025.73 1706.27 1492.33 2037.22 2045.34 1888.94 1674.27 1271.4 1396.04 1706.01 1653.37 1698.37 1674.13 1529.8 1924 1875.6 2319.42 934.279 1146.53 571.61 1024.5 1486.45
SC
37 37 37 37 37 37 37 36 36 36 36 36 36 35 35 35 35 35 35 35 35 34 34 34 34 34 34 34 34 34 33 33 33 33 33 33 33 33 33 33 33 33 33 33 33 33 33 32 32 32 32 32 32 32 32 32 32 31 31 31 31 31
M AN U
TE D
EHD1_MOUSE EH domain-containing protein 1 ACADV_MOUSE Very long-chain specific acyl-CoA dehydrogenase, mitochondrial PRDX6_MOUSE Peroxiredoxin-6 AL9A1_MOUSE 4-trimethylaminobutyraldehyde dehydrogenase DDX3X_MOUSE ATP-dependent RNA helicase DDX3X GLU2B_MOUSE Isoform 2 of Glucosidase 2 subunit beta ODPB_MOUSE Pyruvate dehydrogenase E1 component subunit beta, mitochondrial B2L13_MOUSE Bcl-2-like protein 13 FPPS_MOUSE Farnesyl pyrophosphate synthase HXK2_MOUSE Hexokinase-2 Q91VA7_MOUSE Isocitrate dehydrogenase 3 (NAD+) beta SF3A1_MOUSE Splicing factor 3A subunit 1 RL8_MOUSE 60S ribosomal protein L8 PLIN1_MOUSE Perilipin-1 TCPH_MOUSE T-complex protein 1 subunit eta 6PGD_MOUSE 6-phosphogluconate dehydrogenase, decarboxylating HNRPK_MOUSE Heterogeneous nuclear ribonucleoprotein K NEDD4_MOUSE E3 ubiquitin-protein ligase NEDD4 PAIRB_MOUSE Plasminogen activator inhibitor 1 RNA-binding protein GLOD4_MOUSE Glyoxalase domain-containing protein 4 HOT_MOUSE Hydroxyacid-oxoacid transhydrogenase, mitochondrial ATPO_MOUSE ATP synthase subunit O, mitochondrial IF4G1_MOUSE Eukaryotic translation initiation factor 4 gamma 1 IF2B_MOUSE Eukaryotic translation initiation factor 2 subunit 2 PSMD3_MOUSE 26S proteasome non-ATPase regulatory subunit 3 ACOT2_MOUSE Acyl-coenzyme A thioesterase 2, mitochondrial ACOT9_MOUSE Acyl-coenzyme A thioesterase 9, mitochondrial PCYOX_MOUSE Prenylcysteine oxidase GSTP1_MOUSE Glutathione S-transferase P 1 HNRPD_MOUSE Heterogeneous nuclear ribonucleoprotein D0 RAB7A_MOUSE Ras-related protein Rab-7a UGGG1_MOUSE UDP-glucose:glycoprotein glucosyltransferase 1 Q8C3V4_MOUSE Signal transducer and activator of transcription DCTN1_MOUSE Dynactin subunit 1 HNRPL_MOUSE Heterogeneous nuclear ribonucleoprotein L ERO1A_MOUSE ERO1-like protein alpha TIM44_MOUSE Mitochondrial import inner membrane translocase subunit TIM44 PREP_MOUSE Presequence protease, mitochondrial GPDM_MOUSE Glycerol-3-phosphate dehydrogenase, mitochondrial PRS7_MOUSE 26S protease regulatory subunit 7 RL7A_MOUSE 60S ribosomal protein L7a PUR2_MOUSE Trifunctional purine biosynthetic protein adenosine-3 FKBP9_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP9 IF4A1_MOUSE Eukaryotic initiation factor 4A-I IPYR2_MOUSE Inorganic pyrophosphatase 2, mitochondrial KAP3_MOUSE cAMP-dependent protein kinase type II-beta regulatory subunit FUBP2_MOUSE Far upstream element-binding protein 2 HNRPM_MOUSE Isoform 2 of Heterogeneous nuclear ribonucleoprotein M MYO1C_MOUSE Unconventional myosin-Ic SBP1_MOUSE Selenium-binding protein 1 RTCB_MOUSE tRNA-splicing ligase RtcB homolog RS17_MOUSE 40S ribosomal protein S17 G6PD1_MOUSE Glucose-6-phosphate 1-dehydrogenase X RS15_MOUSE 40S ribosomal protein S15 RL4_MOUSE 60S ribosomal protein L4 PA2G4_MOUSE Proliferation-associated protein 2G4 IF4A2_MOUSE Eukaryotic initiation factor 4A-II CES1D_MOUSE Carboxylesterase 1D MARCS_MOUSE Myristoylated alanine-rich C-kinase substrate RBP2_MOUSE E3 SUMO-protein ligase RanBP2 TOM70_MOUSE Mitochondrial import receptor subunit TOM70 COPD_MOUSE Coatomer subunit delta
EP
Ehd1 Acadvl Prdx6 Aldh9a1 Ddx3x Prkcsh Pdhb Bcl2l13 Fdps Hk2 Idh3b Sf3a1 Rpl8 Plin1 Cct7 Pgd Hnrnpk Nedd4 Serbp1 Glod4 Adhfe1 Atp5o Eif4g1 Eif2s2 Psmd3 Acot2 Acot9 Pcyox1 Gstp1 Hnrnpd Rab7a Uggt1 Stat1 Dctn1 Hnrnpl Ero1l Timm44 Pitrm1 Gpd2 Psmc2 Rpl7a Gart Fkbp9 Eif4a1 Ppa2 Prkar2b Khsrp Hnrnpm Myo1c Selenbp1 Rtcb Rps17 G6pdx Rps15 Rpl4 Pa2g4 Eif4a2 Ces1d Marcks Ranbp2 Tomm70a Arcn1
AC C
sp|Q9WVK4|EHD1_MOUSE sp|P50544|ACADV_MOUSE sp|O08709|PRDX6_MOUSE sp|Q9JLJ2|AL9A1_MOUSE sp|Q62167|DDX3X_MOUSE sp|O08795-2|GLU2B_MOUSE sp|Q9D051|ODPB_MOUSE sp|P59017|B2L13_MOUSE sp|Q920E5|FPPS_MOUSE sp|O08528|HXK2_MOUSE tr|Q91VA7|Q91VA7_MOUSE sp|Q8K4Z5|SF3A1_MOUSE sp|P62918|RL8_MOUSE sp|Q8CGN5|PLIN1_MOUSE sp|P80313|TCPH_MOUSE sp|Q9DCD0|6PGD_MOUSE sp|P61979|HNRPK_MOUSE sp|P46935|NEDD4_MOUSE sp|Q9CY58|PAIRB_MOUSE sp|Q9CPV4|GLOD4_MOUSE sp|Q8R0N6|HOT_MOUSE sp|Q9DB20|ATPO_MOUSE sp|Q6NZJ6|IF4G1_MOUSE sp|Q99L45|IF2B_MOUSE sp|P14685|PSMD3_MOUSE sp|Q9QYR9|ACOT2_MOUSE sp|Q9R0X4|ACOT9_MOUSE sp|Q9CQF9|PCYOX_MOUSE sp|P19157|GSTP1_MOUSE sp|Q60668|HNRPD_MOUSE sp|P51150|RAB7A_MOUSE sp|Q6P5E4|UGGG1_MOUSE tr|Q8C3V4|Q8C3V4_MOUSE sp|O08788|DCTN1_MOUSE sp|Q8R081|HNRPL_MOUSE sp|Q8R180|ERO1A_MOUSE sp|O35857|TIM44_MOUSE sp|Q8K411|PREP_MOUSE sp|Q64521|GPDM_MOUSE sp|P46471|PRS7_MOUSE sp|P12970|RL7A_MOUSE sp|Q64737|PUR2_MOUSE sp|Q9Z247|FKBP9_MOUSE sp|P60843|IF4A1_MOUSE sp|Q91VM9|IPYR2_MOUSE sp|P31324|KAP3_MOUSE sp|Q3U0V1|FUBP2_MOUSE sp|Q9D0E1-2|HNRPM_MOUSE sp|Q9WTI7|MYO1C_MOUSE sp|P17563|SBP1_MOUSE sp|Q99LF4|RTCB_MOUSE sp|P63276|RS17_MOUSE sp|Q00612|G6PD1_MOUSE sp|P62843|RS15_MOUSE sp|Q9D8E6|RL4_MOUSE sp|P50580|PA2G4_MOUSE sp|P10630|IF4A2_MOUSE sp|Q8VCT4|CES1D_MOUSE sp|P26645|MARCS_MOUSE sp|Q9ERU9|RBP2_MOUSE sp|Q9CZW5|TOM70_MOUSE sp|Q5XJY5|COPD_MOUSE
1730.54 1639.09 2497.2 1441.58 2259.65 1500.94 1724.29 1840.42 2490.86 2576.04 1989.56 2029.88 2208.41 1163.31 1290.27 1662.01 1808.57 2181.3 2899.55 1915.35 1444.06 1949.39 2317.51 1477.17 1736.92 2096.74 2245.44 1520.14 1298.76 1727.16 1987.79 1702.1 1626.81 1192.92 1280.73 1387.31 2184.49 1696.9 1774.55 1625.7 2073.72 1662.62 1656.84 1748.53 2020.27 1474.92 1551.48 1293.77 1342.87 1692.87 1521.43 1701.64 1299.8 1364.51 1835 1675.13 1985.11 2029.3 2157.12 879.598 1352.52 1825.91
1324.96 1079.64 1749.86 3105.4 3201.2 1443.9 1737.61 1326.11 1793.84 5717.32 2456.43 1885.18 2260.62 1711.9 3295.08 2400.87 2333.17 1126.29 2041.5 1517.99 758.369 1635.43 1613.68 2653.39 1789.62 1438.82 2219.22 1637.98 1220.72 2294.04 2344.31 1659.36 1583.83 1632.26 2631 3885.6 1983.71 1789.36 1405.63 2324.77 1995.68 2443.65 904.885 1805.87 1162.51 2045.58 1572.16 2802.63 2036.23 2123.73 2117.53 1704.25 2182.54 1417.47 1909.7 2781.88 1481.77 1849.85 786.056 4083.95 4679.8 2250.34
1270.41 1602.08 4462.56 3357.39 4344.8 2689.57 4038.56 1358.53 1235.28 3159.38 3705.06 2174.52 3547.59 4708.7 2052.53 2239.03 3759.09 1821.19 2918.85 2774.27 1708.87 1555.72 2469.39 2785.91 1457.71 2027.22 2159.21 1480.22 1685.88 4220.94 1842.21 1576.38 2091.35 1866.43 4714.73 1746.83 3237.35 2072.28 1625.94 2445.79 1753.59 2233.07 1568.16 1717.02 3129.76 2354.13 2925.14 3407.55 1508.15 2059.62 2777.58 3138.35 2253.97 2561.81 2153.21 2451.87 1810.39 3351.12 1114.74 5510.73 4269.96 2661.27
1.14 1.13 1.02 1.02 1.01 1.01 0.91 1.30 1.25 1.20 1.08 0.96 0.91 1.34 1.13 1.07 1.05 1.05 0.99 0.90 0.82 1.81 1.25 1.23 1.19 1.03 1.02 0.97 0.95 0.86 1.25 1.23 1.17 1.16 1.12 1.11 1.11 1.10 1.08 1.05 1.05 1.02 1.01 0.97 0.97 0.95 0.93 1.19 1.10 1.04 1.04 1.03 1.01 0.98 0.95 0.93 0.86 2.80 1.57 1.35 1.25 1.21
0.70 0.72 1.16 2.04 1.70 1.21 1.37 0.88 0.77 2.20 1.40 0.93 1.23 3.09 2.18 1.35 1.84 0.74 0.82 0.94 0.59 1.12 1.16 2.04 1.08 0.78 0.88 0.93 0.96 1.55 1.16 1.02 1.15 1.51 3.21 1.99 1.19 1.08 0.87 1.46 0.97 1.43 0.77 0.93 1.01 1.28 1.24 2.71 1.33 1.23 1.51 1.43 1.48 1.30 1.09 1.45 0.77 3.14 0.76 7.46 4.12 1.57
ACCEPTED MANUSCRIPT
1343.92 1340.1 1738.5 1347.72 1154.71 1721.09 1322.41 1362.48 1081.79 1799.11 1516.52 1533.9 1359.42 1120.05 1356 1596.5 1626.61 1713.49 1206.39 1720.85 1462.89 1645.4 1063.44 1012.66 1383.52 1057.6 1181.25 1255.17 1104 1451.48 1489.92 1560.36 1006.51 1101.09 1727.58 1318.15 1548.06 1428.87 1316.77 1993.53 1727.37 1836.82 2336.67 922.413 1259.25 1467.55 1251.05 1605.85 1265.07 1446.23 1387.25 1122.74 1165.56 1843.5 1078.83 1422.38 2458.21 409.228 1454.65 1162.85 1745.96 1327.2
1784.51 1806.15 1738.88 1644.63 1354.7 1521.57 2141.01 2073.82 1510.62 1788.63 1725.09 1616.89 1799.25 1304.72 1795.41 2006.79 1905.81 1720.65 1842.71 1509.34 1713.8 2273.55 1724.66 1327.71 1728.11 1594.03 1692.47 1579.11 1378.48 1732.16 1652.78 1645.34 1264.08 1253.27 1469.44 1385.42 1543.17 1439.01 1538.43 1734.81 1789.26 1644.86 1844.86 1330.86 1744.31 2033.76 1287.9 1778.46 1384.1 1576.67 1562.56 1509.04 1416.85 1761.7 1243.19 1477.36 2340.9 2808.94 2230.84 1701.86 1737.97 1582.94
RI PT
1424.04 1490.82 1787.56 1554.94 1255.32 1642.06 1441.4 1273.08 1007.27 1265.92 1313.8 1283.86 1489.77 1102.06 1720.66 1912.8 1651.84 1463.56 2034.61 1405.31 1995.46 1585.31 1392.86 960.026 1258.47 1339.58 1362.25 1447.35 1098.28 1602.38 1479.94 1650.59 1281.97 1257.06 1234.62 1469.1 1653.12 1660.47 1650.24 1169.11 1841.94 1746.35 2623.23 1060.86 1292.81 1703.63 1235.02 1441.36 1328.33 1632.06 1520.44 1579.62 1343.31 1576.76 1397.84 1462.12 2523.9 1306.95 1368.46 1402.33 1450.88 1368.03
SC
31 31 31 31 31 31 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 28 28 28 28 28 28 28 28 28 28 28 28 28 28 27 27 27 27 27
M AN U
TE D
AP1B1_MOUSE AP-1 complex subunit beta-1 F8VQJ3_MOUSE Laminin subunit gamma-1 GLNA_MOUSE Glutamine synthetase GBLP_MOUSE Guanine nucleotide-binding protein subunit beta-2-like 1 SEPT2_MOUSE Septin-2 PRDX2_MOUSE Peroxiredoxin-2 AACS_MOUSE Acetoacetyl-CoA synthetase MBB1A_MOUSE Myb-binding protein 1A COPG1_MOUSE Coatomer subunit gamma-1 IF5A1_MOUSE Eukaryotic translation initiation factor 5A-1 E9PVA8_MOUSE Protein Gcn1l1 HDGF_MOUSE Hepatoma-derived growth factor PSMD1_MOUSE 26S proteasome non-ATPase regulatory subunit 1 SYIM_MOUSE Isoleucine--tRNA ligase, mitochondrial LAMP2_MOUSE Lysosome-associated membrane glycoprotein 2 SYK_MOUSE Lysine--tRNA ligase RS7_MOUSE 40S ribosomal protein S7 PEBP1_MOUSE Phosphatidylethanolamine-binding protein 1 PCCA_MOUSE Propionyl-CoA carboxylase alpha chain, mitochondrial CALM_MOUSE Calmodulin HYES_MOUSE Bifunctional epoxide hydrolase 2 GSLG1_MOUSE Golgi apparatus protein 1 MPRI_MOUSE Cation-independent mannose-6-phosphate receptor TCPG_MOUSE T-complex protein 1 subunit gamma RCN1_MOUSE Reticulocalbin-1 AL1L2_MOUSE Mitochondrial 10-formyltetrahydrofolate dehydrogenase CCD47_MOUSE Coiled-coil domain-containing protein 47 SC31A_MOUSE Protein transport protein Sec31A CKAP4_MOUSE Cytoskeleton-associated protein 4 PPCE_MOUSE Prolyl endopeptidase SEPT9_MOUSE Septin-9 ERF1_MOUSE Eukaryotic peptide chain release factor subunit 1 UCRI_MOUSE Cytochrome b-c1 complex subunit Rieske, mitochondrial GDIR1_MOUSE Rho GDP-dissociation inhibitor 1 DDX5_MOUSE Probable ATP-dependent RNA helicase DDX5 ALD2_MOUSE Aldose reductase-related protein 2 RS6_MOUSE 40S ribosomal protein S6 WDR1_MOUSE WD repeat-containing protein 1 IF2B2_MOUSE Insulin-like growth factor 2 mRNA-binding protein 2 E9QP99_MOUSE Golgin subfamily A member 3 CLYBL_MOUSE Citrate lyase subunit beta-like protein, mitochondrial PPID_MOUSE Peptidyl-prolyl cis-trans isomerase D APMAP_MOUSE Adipocyte plasma membrane-associated protein DIC_MOUSE Mitochondrial dicarboxylate carrier USO1_MOUSE General vesicular transport factor p115 TPP2_MOUSE Tripeptidyl-peptidase 2 DHB4_MOUSE Peroxisomal multifunctional enzyme type 2 ICAL_MOUSE Calpastatin CLU_MOUSE Clustered mitochondria protein homolog RL18_MOUSE 60S ribosomal protein L18 ARF5_MOUSE ADP-ribosylation factor 5 ODO1_MOUSE 2-oxoglutarate dehydrogenase, mitochondrial UBP14_MOUSE Ubiquitin carboxyl-terminal hydrolase 14 F10A1_MOUSE Hsc70-interacting protein VATA_MOUSE V-type proton ATPase catalytic subunit A PSA5_MOUSE Proteasome subunit alpha type-5 EP15R_MOUSE Epidermal growth factor receptor substrate 15-like 1 CO1A1_MOUSE Collagen alpha-1(I) chain APOOL_MOUSE Apolipoprotein O-like ATLA3_MOUSE Atlastin-3 KCY_MOUSE UMP-CMP kinase SERA_MOUSE D-3-phosphoglycerate dehydrogenase
EP
Ap1b1 Lamc1 Glul Gnb2l1 02-Sep Prdx2 Aacs Mybbp1a Copg1 Eif5a Gcn1l1 Hdgf Psmd1 Iars2 Lamp2 Kars Rps7 Pebp1 Pcca Calm1 Ephx2 Glg1 Igf2r Cct3 Rcn1 Aldh1l2 Ccdc47 Sec31a Ckap4 Prep 09-Sep Etf1 Uqcrfs1 Arhgdia Ddx5 Akr1b8 Rps6 Wdr1 Igf2bp2 Golga3 Clybl Ppid Apmap Slc25a10 Uso1 Tpp2 Hsd17b4 Cast Cluh Rpl18 Arf5 Ogdh Usp14 St13 Atp6v1a Psma5 Eps15l1 Col1a1 Apool Atl3 Cmpk1 Phgdh
AC C
sp|O35643|AP1B1_MOUSE tr|F8VQJ3|F8VQJ3_MOUSE sp|P15105|GLNA_MOUSE sp|P68040|GBLP_MOUSE sp|P42208|SEPT2_MOUSE sp|Q61171|PRDX2_MOUSE sp|Q9D2R0|AACS_MOUSE sp|Q7TPV4|MBB1A_MOUSE sp|Q9QZE5|COPG1_MOUSE sp|P63242|IF5A1_MOUSE tr|E9PVA8|E9PVA8_MOUSE sp|P51859|HDGF_MOUSE sp|Q3TXS7|PSMD1_MOUSE sp|Q8BIJ6|SYIM_MOUSE sp|P17047|LAMP2_MOUSE sp|Q99MN1|SYK_MOUSE sp|P62082|RS7_MOUSE sp|P70296|PEBP1_MOUSE sp|Q91ZA3|PCCA_MOUSE sp|P62204|CALM_MOUSE sp|P34914|HYES_MOUSE sp|Q61543|GSLG1_MOUSE sp|Q07113|MPRI_MOUSE sp|P80318|TCPG_MOUSE sp|Q05186|RCN1_MOUSE sp|Q8K009|AL1L2_MOUSE sp|Q9D024|CCD47_MOUSE sp|Q3UPL0|SC31A_MOUSE sp|Q8BMK4|CKAP4_MOUSE sp|Q9QUR6|PPCE_MOUSE sp|Q80UG5|SEPT9_MOUSE sp|Q8BWY3|ERF1_MOUSE sp|Q9CR68|UCRI_MOUSE sp|Q99PT1|GDIR1_MOUSE sp|Q61656|DDX5_MOUSE sp|P45377|ALD2_MOUSE sp|P62754|RS6_MOUSE sp|O88342|WDR1_MOUSE sp|Q5SF07|IF2B2_MOUSE tr|E9QP99|E9QP99_MOUSE sp|Q8R4N0|CLYBL_MOUSE sp|Q9CR16|PPID_MOUSE sp|Q9D7N9|APMAP_MOUSE sp|Q9QZD8|DIC_MOUSE sp|Q9Z1Z0|USO1_MOUSE sp|Q64514|TPP2_MOUSE sp|P51660|DHB4_MOUSE sp|P51125|ICAL_MOUSE sp|Q5SW19|CLU_MOUSE sp|P35980|RL18_MOUSE sp|P84084|ARF5_MOUSE sp|Q60597|ODO1_MOUSE sp|Q9JMA1|UBP14_MOUSE sp|Q99L47|F10A1_MOUSE sp|P50516|VATA_MOUSE sp|Q9Z2U1|PSA5_MOUSE sp|Q60902|EP15R_MOUSE sp|P11087|CO1A1_MOUSE sp|Q78IK4|APOOL_MOUSE sp|Q91YH5|ATLA3_MOUSE sp|Q9DBP5|KCY_MOUSE sp|Q61753|SERA_MOUSE
1513.56 1345.74 1970.93 1397.4 1129.84 1381.98 2029.39 1780.48 1272.79 2232.53 1762.4 1581.65 1434.34 1212.24 1536.11 1767.77 1617.6 1544.24 1314.88 1364.04 1326.74 2008.98 1305.35 1084.12 1384.57 1194.09 1160.97 1430.85 1061.56 1603.55 1530.04 1709.57 1100.41 1143.34 1541.02 1442.13 1636.4 1531.43 1300.74 1261.05 1504.54 1376.64 1611.86 1582.2 1248.53 1537.57 1400.8 1459.99 1290.31 1581.29 1375.99 1217.5 1089.35 1546.67 1021.45 1147.6 1791.85 779.325 2095.81 1267.14 1833.17 1310.33
2523.94 947.977 841.277 2802.96 1319.4 1309.2 2076.95 1972.29 2060.96 2291.58 2536.07 2185.85 2590.53 2437.17 1123.11 2274.64 1494.45 1349.03 1492.69 1218.7 1481.97 1998.45 1345.88 2716.14 1241.41 1737.09 1546.29 2208.46 1313.42 2130.61 2055.07 2257.09 855.312 1062.85 2188.25 1745.38 1852.06 3458.13 1189.5 1587.86 1406.2 3332.1 1735.27 1343.82 2085.23 1974.04 1695.7 626.351 1584.77 1394.11 1635.2 2330.87 1860.73 1908.15 2061.26 1425.27 1271.52 403.148 1545.67 1122.43 1192.42 2145.76
2290.15 1339.4 4820.28 2349.36 1402.59 2315.85 2196.88 1918.47 1829.07 5484 1998.79 3900.52 2238.33 2446.39 1217.98 1802.92 1752.78 2531.39 2149.5 3415.73 1742.61 1520.56 1023.34 1841.99 2203.88 999.796 1431.28 2890.49 1115.11 1393.42 1654.6 1869.88 1058.42 1446.54 4538.97 1968.32 2962.04 2999.27 1281.76 1549.8 2199.96 4319.73 1763.2 1250.14 1631.44 1613.3 1609.17 1340.41 2004.48 996.688 1310.28 2212.69 1490.23 3617.88 1865.36 1924.39 2116.9 392.783 1302.57 944.65 2360.09 2705.1
1.19 1.11 1.05 1.05 1.03 0.86 1.51 1.46 1.33 1.31 1.23 1.14 1.13 1.13 1.08 1.08 1.07 1.03 0.97 0.92 0.88 1.33 1.23 1.22 1.18 1.16 1.12 1.11 1.11 1.09 1.07 1.04 1.03 1.02 1.02 1.01 0.99 0.96 0.96 0.95 0.92 0.84 0.70 1.47 1.17 1.13 1.08 1.06 1.03 1.03 1.01 1.01 1.00 0.97 0.91 0.91 0.83 2.09 1.53 1.16 1.12 1.07
1.74 0.81 1.61 1.78 1.13 1.08 1.55 1.48 1.86 2.54 1.60 2.16 1.69 2.20 0.76 1.16 0.99 1.22 1.12 1.48 0.93 1.09 0.96 2.31 1.30 1.14 1.17 1.89 1.10 1.15 1.25 1.29 0.84 1.06 2.27 1.33 1.50 2.09 0.83 0.99 1.01 2.14 0.71 1.31 1.46 1.13 1.33 0.65 1.38 0.78 1.01 1.68 1.34 1.62 1.59 1.16 0.68 0.46 1.01 0.81 1.11 1.80
ACCEPTED MANUSCRIPT
TE D
1890.59 1313.62 1167.66 1260.64 1480.07 1804.42 1552.93 1387.42 1116.94 1530.7 1572.16 2304.06 1551.14 1604.63 1435.62 1890.29 1062.12 2590.7 986.584 914.476 756.134 1219.63 1383.58 1145.15 916.27 1263.78 1043.34 1339.7 1070.62 1662.36 1530.15 430.317 1380.48 1198.14 1193.28 988.719 1176.13 1331.27 835.237 1171.54 987.943 976.321 1843.01 958.195 801.876 961.238 1438.68 1332.03 1098.24 1356.49 1081.08 1090.93 1556.64 1307.44 882.176 1612.77 1089.26 1392.33 1151.79 1574.62 1661.79 1415.65
2096.67 1860.39 1557.65 1377.14 1747.1 1847.67 1433.76 1394.3 1104.86 1927.68 1630.37 2231.78 1570.39 1570.17 1270.5 1726.55 1504.62 2891.78 1331.6 1333.07 1406.39 1700.12 1691.14 1517.16 972.41 1345.63 1204.75 1284.9 1160.76 1618.03 1491.18 415.023 1392.21 1082.83 1798.89 1287.77 1633.16 1669.8 1122.97 1496.3 1243.97 1539.07 2313.48 1321.74 1162.25 1034.19 2107.3 1378.3 1397.24 1383.21 1146.26 1222.87 1962.18 1710.11 999.134 1812.41 1252.45 1461.56 1074.8 1413.75 1555.07 1388.86
RI PT
2197.04 1715.09 1380.49 1145.91 1553.67 1795.27 1404.8 1229.69 1096.65 2099.47 1459.93 2105.93 1550.66 1623.52 1304.14 1715.28 1216.37 1452.61 1074.48 1014.47 1160.73 1567.54 1544.93 1435.44 837.771 1318.17 1195.54 1191.16 1360.32 1629.79 1454.81 388.48 1266.45 1334.32 1323.11 1028.51 1192.77 1285.12 894.516 1080.29 1113.5 1369.41 1962.26 1159.3 975.584 927.992 1780.18 1312.49 1311.43 1347.98 933.753 1109.96 2010.87 1611.38 1065.7 1903.1 1309.59 1543.26 1015.9 1384.1 1681.5 1434.93
SC
27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25
M AN U
ADT1_MOUSE ADP/ATP translocase 1 LRP1_MOUSE Prolow-density lipoprotein receptor-related protein 1 EIF3C_MOUSE Eukaryotic translation initiation factor 3 subunit C CYB5_MOUSE Cytochrome b5 IF2B3_MOUSE Insulin-like growth factor 2 mRNA-binding protein 3 LGUL_MOUSE Lactoylglutathione lyase FKBP4_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP4 SYAP1_MOUSE Synapse-associated protein 1 SPEE_MOUSE Spermidine synthase ABCF1_MOUSE ATP-binding cassette sub-family F member 1 Q3UJB0_MOUSE Protein Sf3b2 RL23A_MOUSE 60S ribosomal protein L23a PRS6B_MOUSE 26S protease regulatory subunit 6B CLIC4_MOUSE Chloride intracellular channel protein 4 PEX19_MOUSE Peroxisomal biogenesis factor 19 ERP29_MOUSE Endoplasmic reticulum resident protein 29 PRP8_MOUSE Pre-mRNA-processing-splicing factor 8 CBR2_MOUSE Carbonyl reductase [NADPH] 2 PSMD2_MOUSE 26S proteasome non-ATPase regulatory subunit 2 SCFD1_MOUSE Sec1 family domain-containing protein 1 MARC2_MOUSE Mitochondrial amidoxime reducing component 2 AL7A1_MOUSE Alpha-aminoadipic semialdehyde dehydrogenase SF3B1_MOUSE Splicing factor 3B subunit 1 CLPX_MOUSE ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial Q6ZWZ6_MOUSE 40S ribosomal protein S12 KINH_MOUSE Kinesin-1 heavy chain RUVB1_MOUSE RuvB-like 1 AN32A_MOUSE Acidic leucine-rich nuclear phosphoprotein 32 family member A ETFD_MOUSE Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial IF5_MOUSE Eukaryotic translation initiation factor 5 STRAP_MOUSE Serine-threonine kinase receptor-associated protein RINI_MOUSE Ribonuclease inhibitor CLIP1_MOUSE CAP-Gly domain-containing linker protein 1 RS8_MOUSE 40S ribosomal protein S8 SYTC_MOUSE Threonine--tRNA ligase, cytoplasmic E41L2_MOUSE Band 4.1-like protein 2 RS4X_MOUSE 40S ribosomal protein S4, X isoform RS18_MOUSE 40S ribosomal protein S18 SYRC_MOUSE Arginine--tRNA ligase, cytoplasmic THIL_MOUSE Acetyl-CoA acetyltransferase, mitochondrial ADT2_MOUSE ADP/ATP translocase 2 U5S1_MOUSE 116 kDa U5 small nuclear ribonucleoprotein component RS3_MOUSE 40S ribosomal protein S3 SMC3_MOUSE Structural maintenance of chromosomes protein 3 PUR9_MOUSE Bifunctional purine biosynthesis protein PURH COPB_MOUSE Coatomer subunit beta NMT1_MOUSE Glycylpeptide N-tetradecanoyltransferase 1 TIF1B_MOUSE Transcription intermediary factor 1-beta E41L1_MOUSE Isoform 2 of Band 4.1-like protein 1 ERF3A_MOUSE Eukaryotic peptide chain release factor GTP-binding subunit ERF3A UB2L3_MOUSE Ubiquitin-conjugating enzyme E2 L3 HS71A_MOUSE Heat shock 70 kDa protein 1A LA_MOUSE Lupus La protein homolog ECI1_MOUSE Enoyl-CoA delta isomerase 1, mitochondrial AHSA1_MOUSE Activator of 90 kDa heat shock protein ATPase homolog 1 PRS8_MOUSE 26S protease regulatory subunit 8 HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mitochondrial PLST_MOUSE Plastin-3 PRC2C_MOUSE Protein PRRC2C YBOX1_MOUSE Nuclease-sensitive element-binding protein 1 GSTO1_MOUSE Glutathione S-transferase omega-1 RB6I2_MOUSE ELKS/Rab6-interacting/CAST family member 1
EP
Slc25a4 Lrp1 Eif3c Cyb5a Igf2bp3 Glo1 Fkbp4 Syap1 Srm Abcf1 Sf3b2 Rpl23a Psmc4 Clic4 Pex19 Erp29 Prpf8 Cbr2 Psmd2 Scfd1 02-Mar Aldh7a1 Sf3b1 Clpx Rps12 Kif5b Ruvbl1 Anp32a Etfdh Eif5 Strap Rnh1 Clip1 Rps8 Tars Epb41l2 Rps4x Rps18 Rars Acat1 Slc25a5 Eftud2 Rps3 Smc3 Atic Copb1 Nmt1 Trim28 Epb41l1 Gspt1 Ube2l3 Hspa1a Ssb Eci1 Ahsa1 Psmc5 Hmgcl Pls3 Prrc2c Ybx1 Gsto1 Erc1
AC C
sp|P48962|ADT1_MOUSE sp|Q91ZX7|LRP1_MOUSE sp|Q8R1B4|EIF3C_MOUSE sp|P56395|CYB5_MOUSE sp|Q9CPN8|IF2B3_MOUSE sp|Q9CPU0|LGUL_MOUSE sp|P30416|FKBP4_MOUSE sp|Q9D5V6|SYAP1_MOUSE sp|Q64674|SPEE_MOUSE sp|Q6P542|ABCF1_MOUSE tr|Q3UJB0|Q3UJB0_MOUSE sp|P62751|RL23A_MOUSE sp|P54775|PRS6B_MOUSE sp|Q9QYB1|CLIC4_MOUSE sp|Q8VCI5|PEX19_MOUSE sp|P57759|ERP29_MOUSE sp|Q99PV0|PRP8_MOUSE sp|P08074|CBR2_MOUSE sp|Q8VDM4|PSMD2_MOUSE sp|Q8BRF7|SCFD1_MOUSE sp|Q922Q1|MARC2_MOUSE sp|Q9DBF1|AL7A1_MOUSE sp|Q99NB9|SF3B1_MOUSE sp|Q9JHS4|CLPX_MOUSE tr|Q6ZWZ6|Q6ZWZ6_MOUSE sp|Q61768|KINH_MOUSE sp|P60122|RUVB1_MOUSE sp|O35381|AN32A_MOUSE sp|Q921G7|ETFD_MOUSE sp|P59325|IF5_MOUSE sp|Q9Z1Z2|STRAP_MOUSE sp|Q91VI7|RINI_MOUSE sp|Q922J3|CLIP1_MOUSE sp|P62242|RS8_MOUSE sp|Q9D0R2|SYTC_MOUSE sp|O70318|E41L2_MOUSE sp|P62702|RS4X_MOUSE sp|P62270|RS18_MOUSE sp|Q9D0I9|SYRC_MOUSE sp|Q8QZT1|THIL_MOUSE sp|P51881|ADT2_MOUSE sp|O08810|U5S1_MOUSE sp|P62908|RS3_MOUSE sp|Q9CW03|SMC3_MOUSE sp|Q9CWJ9|PUR9_MOUSE sp|Q9JIF7|COPB_MOUSE sp|O70310|NMT1_MOUSE sp|Q62318|TIF1B_MOUSE sp|Q9Z2H5-2|E41L1_MOUSE sp|Q8R050|ERF3A_MOUSE sp|P68037|UB2L3_MOUSE sp|Q61696|HS71A_MOUSE sp|P32067|LA_MOUSE sp|P42125|ECI1_MOUSE sp|Q8BK64|AHSA1_MOUSE sp|P62196|PRS8_MOUSE sp|P38060|HMGCL_MOUSE sp|Q99K51|PLST_MOUSE sp|Q3TLH4|PRC2C_MOUSE sp|P62960|YBOX1_MOUSE sp|O09131|GSTO1_MOUSE sp|Q99MI1|RB6I2_MOUSE
2270.39 1360.17 1119.9 1125.49 1399.55 1839.88 1543.98 1114.42 1003.29 1527.13 1203.11 1885.68 1322.25 1394.89 1183.83 1480.98 1491.12 2267.3 1275.98 1031.63 924.233 1402.3 1522.92 1087.75 789.003 1205.01 965.513 1146.48 1174 1540.93 1341.4 359.424 1088.01 1255.01 1579.57 1327.86 1309.28 1539.35 986.32 1241.04 1290.83 1252.44 2141.78 1119.46 868.544 1111.04 1475.5 1537.62 1195.56 1444.75 957.345 1065.09 1649.55 1203.33 919.802 1496.82 943.455 1196.56 882.334 1250.48 1440.27 1112.96
2326.69 1653.48 2140.88 826.751 2411.16 501.671 2116.67 996.816 1189.34 1504.86 1077.84 1554.98 1354.95 1570.5 999.25 1435.91 1570.95 1816.74 1340.7 1503.37 3087.31 1308.19 1395.77 1011.42 2932.87 2240.85 2630.81 2114.35 1973.51 2093.99 1792.85 3744.65 1150.41 1329.3 1755.97 977.543 1668.46 1470.43 2761.79 2780.48 2374.69 1765.53 2302.08 1152.92 1011.12 1480.65 1582.42 2320.99 1017.5 1772.83 868.933 1296.65 1447.77 1144.4 1054.33 1884.9 1052.27 1847.56 798.114 1074.33 1573.08 1003.5
1656.74 1278.74 1821.57 2390.85 3228.48 1585.01 1967.46 2029.59 1449.57 2004.6 1946.18 3304.11 1977.75 2105.98 2595.75 2176.95 910.591 2796.78 940.215 1563.71 2857.94 1260.39 1341.44 2954.85 5883.72 2641.72 2001.43 3784.65 1744.27 3142.56 3271.78 6990.77 2097.01 1703.71 1226.7 1462.29 1266.29 1267.53 1419.59 3482.01 1592.8 982.535 1635.81 938.151 894.31 1115.3 1435.11 2678.76 2210.11 1676.28 1791.08 1459.25 1615.1 2003.32 1301.67 2185.49 1855.75 1644.44 1643.08 3220.37 2660.91 1820.31
1.07 1.06 1.05 1.04 1.04 1.02 1.01 0.96 0.95 0.95 0.93 0.93 0.93 0.92 0.90 0.89 1.31 1.28 1.27 1.23 1.22 1.11 1.10 1.01 1.00 0.99 0.97 0.96 0.96 0.96 0.95 0.95 0.94 0.92 1.34 1.30 1.24 1.23 1.22 1.22 1.21 1.19 1.17 1.15 1.14 1.14 1.11 1.10 1.08 1.05 1.04 1.04 1.01 1.00 0.99 0.94 0.92 0.91 0.90 0.90 0.90 0.88
0.97 0.97 1.56 1.34 1.86 0.58 1.38 1.16 1.19 0.97 1.00 1.10 1.07 1.14 1.31 1.00 1.09 1.14 1.11 1.59 3.10 0.92 0.93 1.54 5.03 1.89 2.07 2.33 1.53 1.59 1.70 13.11 1.23 1.20 1.19 1.21 1.24 1.05 2.42 2.78 1.89 1.17 1.03 0.99 1.07 1.37 0.94 1.89 1.34 1.28 1.32 1.25 0.86 1.08 1.21 1.16 1.21 1.19 1.13 1.45 1.27 0.99
ACCEPTED MANUSCRIPT
1377.73 2431.98 1263.44 1630.95 1078.94 1407.34 930.67 1440.51 795.313 1159.5 1273.73 1401.22 859.125 1337.92 1136.92 1040.43 1002.13 1452.49 1073.08 730.091 866.997 1064.25 911.555 1134.39 1244.13 1572.58 981.412 1208.24 1718.42 1067.1 1942.46 873.403 1012.26 1103.03 1294.34 1316.5 857.495 1270.34 1215.55 1270.89 992.482 981.756 969.389 875.516 1089.8 1025.7 1207.61 1078.49 1398.45 1083.84 1074.13 1392.82 1209.2 480.552 814.846 850.3 1004.22 1396.87 1108.75 655.1 767.778 825.645
1109.4 1934.54 909.979 1700.91 1443.61 2310.21 1542.25 1499.18 1093.73 1555.13 1303.26 1495.35 1078 1172.08 1244.75 1205.64 1291.58 1231.15 1246.36 974.392 928.442 1307.86 821.18 1178.06 1363.08 1562.88 999.47 1082.94 1118.96 1469.93 2558.97 1140.91 1255.35 1467.1 1601.54 1421.62 988.125 1541.82 1404.74 1340.74 1202.17 1324.23 1095.04 945.038 1186.97 1128.38 1342.99 1123.7 1317.79 1061.95 1227.53 1128.84 1187.09 2982.03 1438.02 1342.98 1394.85 2054.54 1900.79 1171.43 1204.31 1327.85
RI PT
1281.28 2571.03 1306.57 1558.76 842.141 1156.86 1056.66 1076.77 895.343 1453.2 741.713 1307.68 954.506 1133.48 1154.26 1157.46 1247.92 1378.54 1104.54 1117.02 846.554 1408.84 838.199 1211.36 1460.39 1730.11 1139.71 1454.47 1036.62 825.21 2063.99 945.483 948.686 1184.61 1571.88 1436.13 904.303 1466.3 1311.47 1368.68 1183.76 1234.05 1119.05 902.661 1202.35 1068.61 1168.87 1089.78 1188.1 1067.9 1419.09 1074.67 1361.01 535.598 933.485 865.134 1076.87 1508.98 1093.79 883.089 854.977 958.752
SC
25 25 25 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 22 22 22 22 22 22 22 22 22
M AN U
TE D
Nln Aimp1 Akr1a1 Eci2 Gns Hsph1 Adh5 Hist1h1c Acaa1a Atp5f1 Spag9 Pfkp Pds5b Emc1 Rpn2 Slc25a22 Copb2 Ddx19a Cul1 Wars Sars Eif3l Dnaja3 Rpl13 Eif2s1 Nucb1 Lias Dctn2 Ppp1r7 Hnrnpul2 Cttn Psmb7 Ca3 Myh11 Phb2 Gstz1 Cyb5r3 Cdc42 Mccc1 Snd1 Asph
EIF3I_MOUSE Eukaryotic translation initiation factor 3 subunit I RISC_MOUSE Retinoid-inducible serine carboxypeptidase EIF3F_MOUSE Eukaryotic translation initiation factor 3 subunit F CAV1_MOUSE Caveolin-1 Q99JZ4_MOUSE GTP-binding protein SAR1a PPIB_MOUSE Peptidyl-prolyl cis-trans isomerase B Q91WU0_MOUSE Expressed sequence AU018778 AMRP_MOUSE Alpha-2-macroglobulin receptor-associated protein THIC_MOUSE Acetyl-CoA acetyltransferase, cytosolic U520_MOUSE U5 small nuclear ribonucleoprotein 200 kDa helicase VATE1_MOUSE V-type proton ATPase subunit E 1 COPA_MOUSE Coatomer subunit alpha API5_MOUSE Apoptosis inhibitor 5 UBR4_MOUSE E3 ubiquitin-protein ligase UBR4 ROA1_MOUSE Heterogeneous nuclear ribonucleoprotein A1 HP1B3_MOUSE Heterochromatin protein 1-binding protein 3 SYG_MOUSE Glycine--tRNA ligase ECH1_MOUSE Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial COBL1_MOUSE Cordon-bleu protein-like 1 VDAC2_MOUSE Voltage-dependent anion-selective channel protein 2 CK054_MOUSE Ester hydrolase C11orf54 homolog NEUL_MOUSE Neurolysin, mitochondrial AIMP1_MOUSE Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 AK1A1_MOUSE Alcohol dehydrogenase [NADP(+)] ECI2_MOUSE Isoform 2 of Enoyl-CoA delta isomerase 2, mitochondrial GNS_MOUSE N-acetylglucosamine-6-sulfatase HS105_MOUSE Heat shock protein 105 kDa ADHX_MOUSE Alcohol dehydrogenase class-3 H12_MOUSE Histone H1.2 THIKA_MOUSE 3-ketoacyl-CoA thiolase A, peroxisomal AT5F1_MOUSE ATP synthase F(0) complex subunit B1, mitochondrial JIP4_MOUSE C-Jun-amino-terminal kinase-interacting protein 4 K6PP_MOUSE 6-phosphofructokinase type C PDS5B_MOUSE Sister chromatid cohesion protein PDS5 homolog B EMC1_MOUSE Isoform 2 of ER membrane protein complex subunit 1 RPN2_MOUSE Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 GHC1_MOUSE Mitochondrial glutamate carrier 1 COPB2_MOUSE Coatomer subunit beta' DD19A_MOUSE ATP-dependent RNA helicase DDX19A CUL1_MOUSE Cullin-1 SYWC_MOUSE Tryptophan--tRNA ligase, cytoplasmic SYSC_MOUSE Serine--tRNA ligase, cytoplasmic EIF3L_MOUSE Eukaryotic translation initiation factor 3 subunit L DNJA3_MOUSE DnaJ homolog subfamily A member 3, mitochondrial RL13_MOUSE 60S ribosomal protein L13 IF2A_MOUSE Eukaryotic translation initiation factor 2 subunit 1 NUCB1_MOUSE Nucleobindin-1 LIAS_MOUSE Lipoyl synthase, mitochondrial DCTN2_MOUSE Dynactin subunit 2 PP1R7_MOUSE Protein phosphatase 1 regulatory subunit 7 HNRL2_MOUSE Heterogeneous nuclear ribonucleoprotein U-like protein 2 SRC8_MOUSE Src substrate cortactin PSB7_MOUSE Proteasome subunit beta type-7 CAH3_MOUSE Carbonic anhydrase 3 MYH11_MOUSE Myosin-11 PHB2_MOUSE Prohibitin-2 MAAI_MOUSE Maleylacetoacetate isomerase NB5R3_MOUSE NADH-cytochrome b5 reductase 3 CDC42_MOUSE Cell division control protein 42 homolog MCCA_MOUSE Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial SND1_MOUSE Staphylococcal nuclease domain-containing protein 1 ASPH_MOUSE Aspartyl/asparaginyl beta-hydroxylase
EP
Eif3i Scpep1 Eif3f Cav1 Sar1a Ppib Ces1f Lrpap1 Acat2 Snrnp200 Atp6v1e1 Copa Api5 Ubr4 Hnrnpa1 Hp1bp3 Gars Ech1 Cobll1 Vdac2
AC C
sp|Q9QZD9|EIF3I_MOUSE sp|Q920A5|RISC_MOUSE sp|Q9DCH4|EIF3F_MOUSE sp|P49817|CAV1_MOUSE tr|Q99JZ4|Q99JZ4_MOUSE sp|P24369|PPIB_MOUSE tr|Q91WU0|Q91WU0_MOUSE sp|P55302|AMRP_MOUSE sp|Q8CAY6|THIC_MOUSE sp|Q6P4T2|U520_MOUSE sp|P50518|VATE1_MOUSE sp|Q8CIE6|COPA_MOUSE sp|O35841|API5_MOUSE sp|A2AN08|UBR4_MOUSE sp|P49312|ROA1_MOUSE sp|Q3TEA8|HP1B3_MOUSE sp|Q9CZD3|SYG_MOUSE sp|O35459|ECH1_MOUSE sp|Q3UMF0|COBL1_MOUSE sp|Q60930|VDAC2_MOUSE sp|Q91V76|CK054_MOUSE sp|Q91YP2|NEUL_MOUSE sp|P31230|AIMP1_MOUSE sp|Q9JII6|AK1A1_MOUSE sp|Q9WUR2-2|ECI2_MOUSE sp|Q8BFR4|GNS_MOUSE sp|Q61699|HS105_MOUSE sp|P28474|ADHX_MOUSE sp|P15864|H12_MOUSE sp|Q921H8|THIKA_MOUSE sp|Q9CQQ7|AT5F1_MOUSE sp|Q58A65|JIP4_MOUSE sp|Q9WUA3|K6PP_MOUSE sp|Q4VA53|PDS5B_MOUSE sp|Q8C7X2-2|EMC1_MOUSE sp|Q9DBG6|RPN2_MOUSE sp|Q9D6M3|GHC1_MOUSE sp|O55029|COPB2_MOUSE sp|Q61655|DD19A_MOUSE sp|Q9WTX6|CUL1_MOUSE sp|P32921|SYWC_MOUSE sp|P26638|SYSC_MOUSE sp|Q8QZY1|EIF3L_MOUSE sp|Q99M87|DNJA3_MOUSE sp|P47963|RL13_MOUSE sp|Q6ZWX6|IF2A_MOUSE sp|Q02819|NUCB1_MOUSE sp|Q99M04|LIAS_MOUSE sp|Q99KJ8|DCTN2_MOUSE sp|Q3UM45|PP1R7_MOUSE sp|Q00PI9|HNRL2_MOUSE sp|Q60598|SRC8_MOUSE sp|P70195|PSB7_MOUSE sp|P16015|CAH3_MOUSE sp|O08638|MYH11_MOUSE sp|O35129|PHB2_MOUSE sp|Q9WVL0|MAAI_MOUSE sp|Q9DCN2|NB5R3_MOUSE sp|P60766|CDC42_MOUSE sp|Q99MR8|MCCA_MOUSE sp|Q78PY7|SND1_MOUSE sp|Q8BSY0|ASPH_MOUSE
1069.25 2142.85 1085.09 3292.41 1285.14 1326.66 1212.2 1721.2 933.766 1495.18 1036.04 1543.73 954.774 1576.31 1281.59 1202.91 1100.14 1670.74 952.165 768.673 673.544 947.634 763.659 933.391 1045.63 1350.25 828.857 1077.19 896.302 990.635 2236.9 1012.68 1028.6 1189.4 1680.48 1672.32 991.609 1452.63 1302.03 1477.93 1052.25 964.605 1033.16 852.365 1124.25 967.21 982.585 951.735 1124.15 910.738 1027.75 1097.46 1086.19 3482.27 1421.55 1182.87 1642.93 2147.56 1269.87 889.489 944.846 1007.38
2143.59 1648.33 1228.02 1517.22 1432.85 1608.39 1620.13 655.836 832.663 1580.64 1447.86 1590.42 1095.21 1899.87 1338.71 1589.56 2050.59 2047.45 1414 3316.23 797.778 1023.85 1137.71 959.912 1767 1288.43 2346.64 1397.65 1939.01 1670.49 1894.98 1306.02 2697.79 2028.64 1584.04 1405.51 2462.9 1828.95 1746.82 1196.62 1540.06 1455.75 1229.6 986.268 831.561 1796.09 595.433 1009.83 1136.9 1029.99 1591.12 842.201 1157.57 84.7096 1737.03 1388.56 732.013 2272.51 1578.07 1334.51 1141.3 1125.3
3461.93 1704.73 1346.46 1165.6 1632.82 1488.38 1873.44 1072.16 1000.65 1041.23 1795.85 1404.48 720.141 1850.24 1687.49 1426.49 1626.73 1597.11 2543.05 1052.31 2103.5 1220.85 2081.32 1592.1 2156.9 1345.87 1916.57 1591.14 1561.63 2210.3 1519.17 1930.83 1367.55 2450.37 1297.28 1207.55 1989.58 1373.31 1469.01 995.113 1233.71 1198.37 807.335 1424.25 1075.1 1444.8 1529.61 1763.33 2247.98 1724.49 1559.51 1255.28 1408.29 377.346 916.471 920.947 809.896 1550.75 1354.46 2716.71 1007.29 1009.72
0.82 0.81 0.78 1.57 1.42 1.42 1.39 1.28 1.20 1.17 1.16 1.12 1.12 1.11 1.10 1.10 1.06 1.03 1.01 0.94 0.93 0.91 0.91 0.90 0.89 0.88 0.86 0.81 0.73 1.30 1.20 1.18 1.16 1.16 1.15 1.12 1.12 1.09 1.07 1.07 1.04 1.03 1.02 1.01 1.01 1.00 0.98 0.96 0.94 0.92 0.90 0.90 0.88 6.36 1.64 1.47 1.46 1.45 1.44 1.34 1.32 1.31
2.11 0.67 1.00 0.84 1.60 1.21 1.76 0.69 1.08 1.00 1.61 1.11 1.00 1.52 1.32 1.37 1.63 1.29 1.82 2.37 1.69 0.91 1.84 1.09 1.45 0.80 2.01 1.12 1.27 2.05 0.85 1.78 2.07 1.96 1.01 0.95 2.53 1.17 1.27 0.83 1.27 1.20 0.98 1.36 0.83 1.55 0.89 1.28 1.31 1.28 1.26 0.85 1.00 0.45 1.52 1.35 0.74 1.32 1.33 2.63 1.32 1.20
ACCEPTED MANUSCRIPT
TE D
916.905 804.807 867.087 893.912 1172.87 886.118 1059.42 908.447 1059.93 1170.71 1366.2 1415.64 1147.44 1453.23 1047.62 1112.65 933.825 1062.94 1073.57 902.53 1229.58 906.305 1048.06 980.398 1036.27 1007.51 1143.01 1364.3 1455.94 735.898 535.745 875.483 837.192 1025.31 957.903 1006.06 1402.71 840.388 1042.54 955.739 959.19 946.391 1140.09 806.928 1272.53 1024.94 747.927 1516.93 1329.27 1167.71 1647.9 1522 1938.75 1136.52 1132.7 682.683 719.674 776.377 939.79 1480.39 1150.61 1073.21
1389.48 1036.78 1447.34 1456.3 1033.56 1298.83 1619.84 1271 1435.56 1531.56 1691.11 1859.88 1556.48 1807.5 1399.29 1297.52 1181.82 1010.81 1112.64 1000.91 1504.34 826.91 1187.77 1110.5 1000.42 1096.51 1168.05 1326.48 1116.94 1470.37 1080.11 1959.58 1489.62 1576.76 1293.94 1503.34 2019.94 1104.44 954.804 1304.4 894.471 1107.14 1103.45 966.239 1453.35 955.876 1000.28 1525.96 1310.17 1042.5 1612.42 1280.23 1269.84 985.231 1569.53 925.536 1164.19 1259.44 1317.38 1777.87 1745.09 1423.52
RI PT
1034.6 808.851 1037.62 1080.23 769.526 962.758 1229.6 1018 1191.67 1262.34 1495.62 1444.16 1334.4 1700.92 1233.38 1287.23 1157.98 1039.86 1212.4 931.996 1494.94 854.685 1205.96 1281.98 1093.44 1250.92 1413.57 1548.81 1553 623.442 710.393 1338.15 999.526 1235.02 1055.07 1125.14 1553.83 896.603 949.431 1030.88 799.278 862.528 987.479 869.143 1238 1032.15 966.029 1393.62 1202.95 1134.77 1641.35 1492.2 1551.15 1400.88 631.021 591.067 788.779 851.736 972.783 1208.29 1338.3 1083.61
SC
22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 22 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 20 20 20 20 20 20 20 20
M AN U
MIA3_MOUSE Melanoma inhibitory activity protein 3 PYR1_MOUSE CAD protein RAB1B_MOUSE Ras-related protein Rab-1B SYFB_MOUSE Phenylalanine--tRNA ligase beta subunit BTF3_MOUSE Transcription factor BTF3 RS19_MOUSE 40S ribosomal protein S19 ACD10_MOUSE Acyl-CoA dehydrogenase family member 10 VATC1_MOUSE V-type proton ATPase subunit C 1 NU214_MOUSE Nuclear pore complex protein Nup214 MAOM_MOUSE NAD-dependent malic enzyme, mitochondrial XPO1_MOUSE Exportin-1 FUS_MOUSE RNA-binding protein FUS SEPT7_MOUSE Septin-7 RL13A_MOUSE 60S ribosomal protein L13a EFGM_MOUSE Elongation factor G, mitochondrial RENT1_MOUSE Regulator of nonsense transcripts 1 IDHG1_MOUSE Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial VATB2_MOUSE V-type proton ATPase subunit B, brain isoform 2AAA_MOUSE Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform SRP68_MOUSE Signal recognition particle subunit SRP68 IMDH2_MOUSE Inosine-5'-monophosphate dehydrogenase 2 TBB5_MOUSE Tubulin beta-5 chain PGES2_MOUSE Prostaglandin E synthase 2 BLMH_MOUSE Bleomycin hydrolase NDUBA_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 LMNB1_MOUSE Lamin-B1 EIF3B_MOUSE Eukaryotic translation initiation factor 3 subunit B ITA6_MOUSE Integrin alpha-6 ANXA5_MOUSE Annexin A5 GSTM1_MOUSE Glutathione S-transferase Mu 1 AL1L1_MOUSE Cytosolic 10-formyltetrahydrofolate dehydrogenase CO5A1_MOUSE Collagen alpha-1(V) chain NOP56_MOUSE Nucleolar protein 56 MACF1_MOUSE Microtubule-actin cross-linking factor 1 NOMO1_MOUSE Nodal modulator 1 Q5XJF6_MOUSE Ribosomal protein CTGE5_MOUSE cTAGE family member 5 4F2_MOUSE 4F2 cell-surface antigen heavy chain RS23_MOUSE 40S ribosomal protein S23 SYFA_MOUSE Phenylalanine--tRNA ligase alpha subunit USP9X_MOUSE Probable ubiquitin carboxyl-terminal hydrolase FAF-X SUCA_MOUSE Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial RL23_MOUSE 60S ribosomal protein L23 DC1I2_MOUSE Cytoplasmic dynein 1 intermediate chain 2 QCR7_MOUSE Cytochrome b-c1 complex subunit 7 UBP5_MOUSE Ubiquitin carboxyl-terminal hydrolase 5 GSHR_MOUSE Glutathione reductase, mitochondrial BCLF1_MOUSE Bcl-2-associated transcription factor 1 GLRX3_MOUSE Glutaredoxin-3 CSDE1_MOUSE Cold shock domain-containing protein E1 HNRPC_MOUSE Heterogeneous nuclear ribonucleoproteins C1/C2 PSA4_MOUSE Proteasome subunit alpha type-4 NUDC_MOUSE Nuclear migration protein nudC LCAP_MOUSE Leucyl-cystinyl aminopeptidase H4_MOUSE Histone H4 SPRC_MOUSE SPARC ATAD3_MOUSE ATPase family AAA domain-containing protein 3 RAB1A_MOUSE Ras-related protein Rab-1A PUR6_MOUSE Multifunctional protein ADE2 FKBP7_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP7 ABCE1_MOUSE ATP-binding cassette sub-family E member 1 DDX21_MOUSE Nucleolar RNA helicase 2
EP
Mia3 Cad Rab1b Farsb Btf3 Rps19 Acad10 Atp6v1c1 Nup214 Me2 Xpo1 Fus septin7 Rpl13a Gfm1 Upf1 Idh3g Atp6v1b2 Ppp2r1a Srp68 Impdh2 Tubb5 Ptges2 Blmh Ndufb10 Lmnb1 Eif3b Itga6 Anxa5 Gstm1 Aldh1l1 Col5a1 Nop56 Macf1 Nomo1 Rpl10a Ctage5 Slc3a2 Rps23 Farsa Usp9x Suclg1 Rpl23 Dync1i2 Uqcrb Usp5 Gsr Bclaf1 Glrx3 Csde1 Hnrnpc Psma4 Nudc Lnpep Hist1h4a Sparc Atad3 Rab1A Paics Fkbp7 Abce1 Ddx21
AC C
sp|Q8BI84|MIA3_MOUSE sp|B2RQC6|PYR1_MOUSE sp|Q9D1G1|RAB1B_MOUSE sp|Q9WUA2|SYFB_MOUSE sp|Q64152|BTF3_MOUSE sp|Q9CZX8|RS19_MOUSE sp|Q8K370|ACD10_MOUSE sp|Q9Z1G3|VATC1_MOUSE sp|Q80U93|NU214_MOUSE sp|Q99KE1|MAOM_MOUSE sp|Q6P5F9|XPO1_MOUSE sp|P56959|FUS_MOUSE sp|O55131|SEPT7_MOUSE sp|P19253|RL13A_MOUSE sp|Q8K0D5|EFGM_MOUSE sp|Q9EPU0|RENT1_MOUSE sp|P70404|IDHG1_MOUSE sp|P62814|VATB2_MOUSE sp|Q76MZ3|2AAA_MOUSE sp|Q8BMA6|SRP68_MOUSE sp|P24547|IMDH2_MOUSE sp|P99024|TBB5_MOUSE sp|Q8BWM0|PGES2_MOUSE sp|Q8R016|BLMH_MOUSE sp|Q9DCS9|NDUBA_MOUSE sp|P14733|LMNB1_MOUSE sp|Q8JZQ9|EIF3B_MOUSE sp|Q61739|ITA6_MOUSE sp|P48036|ANXA5_MOUSE sp|P10649|GSTM1_MOUSE sp|Q8R0Y6|AL1L1_MOUSE sp|O88207|CO5A1_MOUSE sp|Q9D6Z1|NOP56_MOUSE sp|Q9QXZ0|MACF1_MOUSE sp|Q6GQT9|NOMO1_MOUSE tr|Q5XJF6|Q5XJF6_MOUSE sp|Q8R311|CTGE5_MOUSE sp|P10852|4F2_MOUSE sp|P62267|RS23_MOUSE sp|Q8C0C7|SYFA_MOUSE sp|P70398|USP9X_MOUSE sp|Q9WUM5|SUCA_MOUSE sp|P62830|RL23_MOUSE sp|O88487|DC1I2_MOUSE sp|Q9D855|QCR7_MOUSE sp|P56399|UBP5_MOUSE sp|P47791|GSHR_MOUSE sp|Q8K019|BCLF1_MOUSE sp|Q9CQM9|GLRX3_MOUSE sp|Q91W50|CSDE1_MOUSE sp|Q9Z204|HNRPC_MOUSE sp|Q9R1P0|PSA4_MOUSE sp|O35685|NUDC_MOUSE sp|Q8C129|LCAP_MOUSE sp|P62806|H4_MOUSE sp|P07214|SPRC_MOUSE sp|Q925I1|ATAD3_MOUSE sp|P62821|RAB1A_MOUSE sp|Q9DCL9|PUR6_MOUSE sp|O54998|FKBP7_MOUSE sp|P61222|ABCE1_MOUSE sp|Q9JIK5|DDX21_MOUSE
1080.08 961.204 903.112 956.071 1337.69 935.848 1129.94 1031.04 1219.57 1255.08 1551.06 1327.47 1186.38 1678.34 1112.94 1262.28 1037.34 1153.07 1234.04 829.21 1186.14 885.458 975.932 1058.62 1018.41 1004.54 1080.64 1102.95 839.943 1044.79 887.048 1198.88 1011.58 1226.57 1153.64 1069.68 1444.59 930.572 1349.7 943.104 1088.8 922.772 1265.68 846.186 1232.42 1143.5 719.338 1258.1 1086.1 1131.04 1413.95 1439.37 1414.42 913.64 1292.12 825.477 833.831 876.724 1101.26 1606.95 1387.7 1286.96
941.952 1814.58 928.484 1421.76 853.913 860.875 1445.53 1359.85 1476.04 1073.59 1857.22 2183.17 1703.23 1577.52 2027.33 1055.74 1509.83 1339.86 1694.02 2127.39 1524.62 1104.78 953.917 1106.74 718.933 941.695 1316.54 1177.46 1442.54 1318.92 1088.43 391.704 1492.94 1188.19 1035.62 1573.76 1238.25 1883.78 1881.08 1078.99 2416.98 1083.61 1213.27 801.969 1074.51 1183.39 968.949 796.162 1610.72 954.08 461.276 1674.11 1898.61 1545.18 1854.77 225.126 645.116 1144.11 1612.82 954.966 1144.69 1451.91
1561.01 1140.36 1031.24 1089.43 1503.48 1411.28 1675.26 917.145 1523.8 1137.99 1211.8 2965.55 1536.03 1165.2 1868.19 1196.66 2040.31 1526.22 1470.99 1713.59 1305.85 1301.8 1074.49 985.762 1283.88 937.061 1108.01 1286.89 375.485 1861.27 1139.9 513.854 701.208 1142.9 845.69 1238.49 1656.49 1019.7 2318.13 1136.5 1317.78 3135.28 2396.32 1153.82 2060.95 1361.78 998.118 1682.81 2983.91 1652.09 1658.24 1139.47 2619.2 758.159 673.826 604.667 801.888 800.008 973.023 2293.64 859.329 1791.44
1.27 1.24 1.23 1.22 1.22 1.21 1.20 1.19 1.18 1.15 1.13 1.11 1.11 1.11 1.10 1.07 1.06 1.03 1.03 1.00 0.99 0.97 0.96 0.96 0.95 0.93 0.88 0.83 0.65 1.85 1.58 1.43 1.36 1.24 1.22 1.21 1.17 1.17 1.16 1.13 1.13 1.12 1.11 1.08 1.07 1.02 1.00 0.96 0.95 0.94 0.92 0.90 0.77 0.75 1.62 1.37 1.32 1.31 1.26 1.26 1.26 1.26
1.28 1.83 1.03 1.27 1.21 1.23 1.36 1.18 1.33 0.91 1.07 1.80 1.31 0.87 1.71 0.94 1.70 1.36 1.38 2.09 1.04 1.37 0.90 0.92 0.94 0.83 0.95 0.85 0.60 2.34 1.79 0.41 1.19 1.03 0.93 1.32 0.98 1.67 2.11 1.12 2.12 2.33 1.70 1.17 1.25 1.24 1.15 0.85 1.81 1.13 0.64 0.93 1.29 0.91 1.43 0.65 0.96 1.19 1.35 1.21 0.81 1.50
ACCEPTED MANUSCRIPT
M AN U
TE D
875.43 1021.37 794.794 877.212 1022.3 1177.17 774.769 1032.01 788.548 918.394 1256.14 740.283 1061.34 805.222 904.597 1218.16 1029.1 1829.49 738.636 1009.95 886.662 907.53 891.791 930.671 952.4 939.188 749.485 1383.54 707.561 1559.45 1107.74 1283.27 1308.9 1567.7 1129.43 1066 1223.22 1050.36 1240.7 869.332 678.099 1220.99 759.505 913.39 870.235 997.806 951.915 845.18 1263.4 658.225 773.361 624.038 1065.13 782.375 865.525 746.17 670.49 1392.5 793.144 917.857 626.747 1162.81
993.105 1423.95 1261.73 1238.85 1342.61 1485.48 1119.46 1334.63 994.357 1225.82 1608.73 941.145 1083.29 1038.79 1102.54 1231.06 1293.39 1740.94 752.648 1314.43 1018.64 950.799 1000.61 943.894 900.585 857.742 849.719 1622.59 838.43 1267.98 1175.38 1253.38 1206.2 1531.93 1137.86 1020.82 996.533 1126.51 1070.51 1628.24 1148.64 1540.26 1164.32 1343.34 1023.76 1281.68 1135.32 977.536 1311.59 987.548 1075.45 613.438 1393.46 922.402 1058.24 1042.27 928.183 1151.17 1115.58 1259.17 759.319 1233.65
RI PT
725.872 1165.83 1107.89 1036.34 990.637 1291.42 1018.79 1200.43 966.98 1050.37 1392.65 848.288 1035.5 968.244 993.287 1275.58 1268.07 1487.35 698.415 1268.76 1046.9 870.897 1134.9 956.012 722.285 880.258 868.247 1754.29 960.405 1202.43 1261.5 1311.73 1243.2 1549.41 1254.1 1114.68 1340.47 1586.27 1347.85 857.965 736.153 1074.95 931.209 942.048 565.799 835.121 945.748 815.899 1014.85 875.34 855.91 514.573 1245.54 760.966 946.713 906.085 886.621 941.265 1030.78 1211.68 679.118 1301.17
SC
AKA12_MOUSE A-kinase anchor protein 12 20 VP13A_MOUSE Vacuolar protein sorting-associated protein 13A 20 CO6A1_MOUSE Collagen alpha-1(VI) chain 20 SAE2_MOUSE SUMO-activating enzyme subunit 2 20 COPG2_MOUSE Coatomer subunit gamma-2 20 GANAB_MOUSE Isoform 2 of Neutral alpha-glucosidase AB 20 SMCA5_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily20 A member 5 RL6_MOUSE 60S ribosomal protein L6 20 ACDSB_MOUSE Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial 20 CSN2_MOUSE COP9 signalosome complex subunit 2 20 VPS35_MOUSE Vacuolar protein sorting-associated protein 35 20 PSD11_MOUSE 26S proteasome non-ATPase regulatory subunit 11 20 DHB12_MOUSE Estradiol 17-beta-dehydrogenase 12 20 D3Z158_MOUSE Protein Qars 20 A2AFQ2_MOUSE 3-hydroxyacyl-CoA dehydrogenase type-2 20 EZRI_MOUSE Ezrin 20 PSA2_MOUSE Proteasome subunit alpha type-2 20 Q3U422_MOUSE NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 20 DEST_MOUSE Destrin 20 SFXN1_MOUSE Sideroflexin-1 20 CAP1_MOUSE Adenylyl cyclase-associated protein 1 20 RRFM_MOUSE Ribosome-recycling factor, mitochondrial 20 SPB6_MOUSE Serpin B6 20 NIT2_MOUSE Omega-amidase NIT2 20 E9Q3G8_MOUSE Protein Nup153 20 ODBB_MOUSE 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 20 E9Q740_MOUSE Signal recognition particle subunit SRP72 20 TOP1_MOUSE DNA topoisomerase 1 20 VDAC3_MOUSE Voltage-dependent anion-selective channel protein 3 20 TXNL1_MOUSE Thioredoxin-like protein 1 20 F7B5B5_MOUSE Protein Hnrnpr 20 E9PYB0_MOUSE Protein Ahnak2 (Fragment) 20 SHLB2_MOUSE Endophilin-B2 20 PSME1_MOUSE Proteasome activator complex subunit 1 20 EPS15_MOUSE Epidermal growth factor receptor substrate 15 20 ITSN1_MOUSE Intersectin-1 20 MLEC_MOUSE Malectin 20 EIF3H_MOUSE Eukaryotic translation initiation factor 3 subunit H 20 E9Q512_MOUSE Protein Trip11 20 RS13_MOUSE 40S ribosomal protein S13 19 VAPB_MOUSE Vesicle-associated membrane protein-associated protein B 19 GDIR2_MOUSE Rho GDP-dissociation inhibitor 2 19 AOFA_MOUSE Amine oxidase [flavin-containing] A 19 CKAP5_MOUSE Cytoskeleton-associated protein 5 19 RU2A_MOUSE U2 small nuclear ribonucleoprotein A' 19 Q9CZN7_MOUSE Serine hydroxymethyltransferase 19 XPO2_MOUSE Exportin-2 19 CHD4_MOUSE Chromodomain-helicase-DNA-binding protein 4 19 IDI1_MOUSE Isopentenyl-diphosphate Delta-isomerase 1 19 HSDL2_MOUSE Hydroxysteroid dehydrogenase-like protein 2 19 PSMD7_MOUSE 26S proteasome non-ATPase regulatory subunit 7 19 THIO_MOUSE Thioredoxin 19 KAPCA_MOUSE cAMP-dependent protein kinase catalytic subunit alpha 19 IF4G2_MOUSE Eukaryotic translation initiation factor 4 gamma 2 19 IF2B1_MOUSE Insulin-like growth factor 2 mRNA-binding protein 1 19 DDX1_MOUSE ATP-dependent RNA helicase DDX1 19 E9Q7G0_MOUSE Protein Numa1 19 SET_MOUSE Protein SET 19 GTF2I_MOUSE General transcription factor II-I 19 PLOD1_MOUSE Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 19 ODPA_MOUSE Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 19 NAA15_MOUSE N-alpha-acetyltransferase 15, NatA auxiliary subunit 19
EP
Akap12 Vps13a Col6a1 Uba2 Copg2 Ganab Smarca5 Rpl6 Acadsb Cops2 Vps35 Psmd11 Hsd17b12 Qars Hsd17b10 Ezr Psma2 Ndufv3 Dstn Sfxn1 Cap1 Mrrf Serpinb6 Nit2 Nup153 Bckdhb Srp72 Top1 Vdac3 Txnl1 Hnrnpr Ahnak2 Sh3glb2 Psme1 Eps15 Itsn1 Mlec Eif3h Trip11 Rps13 Vapb Arhgdib Maoa Ckap5 Snrpa1 Shmt2 Cse1l Chd4 Idi1 Hsdl2 Psmd7 Txn Prkaca Eif4g2 Igf2bp1 Ddx1 Numa1 Set Gtf2i Plod1 Pdha1 Naa15
AC C
sp|Q9WTQ5|AKA12_MOUSE sp|Q5H8C4|VP13A_MOUSE sp|Q04857|CO6A1_MOUSE sp|Q9Z1F9|SAE2_MOUSE sp|Q9QXK3|COPG2_MOUSE sp|Q8BHN3-2|GANAB_MOUSE sp|Q91ZW3|SMCA5_MOUSE sp|P47911|RL6_MOUSE sp|Q9DBL1|ACDSB_MOUSE sp|P61202|CSN2_MOUSE sp|Q9EQH3|VPS35_MOUSE sp|Q8BG32|PSD11_MOUSE sp|O70503|DHB12_MOUSE tr|D3Z158|D3Z158_MOUSE tr|A2AFQ2|A2AFQ2_MOUSE sp|P26040|EZRI_MOUSE sp|P49722|PSA2_MOUSE tr|Q3U422|Q3U422_MOUSE sp|Q9R0P5|DEST_MOUSE sp|Q99JR1|SFXN1_MOUSE sp|P40124|CAP1_MOUSE sp|Q9D6S7|RRFM_MOUSE sp|Q60854|SPB6_MOUSE sp|Q9JHW2|NIT2_MOUSE tr|E9Q3G8|E9Q3G8_MOUSE sp|Q6P3A8|ODBB_MOUSE tr|E9Q740|E9Q740_MOUSE sp|Q04750|TOP1_MOUSE sp|Q60931|VDAC3_MOUSE sp|Q8CDN6|TXNL1_MOUSE tr|F7B5B5|F7B5B5_MOUSE tr|E9PYB0|E9PYB0_MOUSE sp|Q8R3V5|SHLB2_MOUSE sp|P97371|PSME1_MOUSE sp|P42567|EPS15_MOUSE sp|Q9Z0R4|ITSN1_MOUSE sp|Q6ZQI3|MLEC_MOUSE sp|Q91WK2|EIF3H_MOUSE tr|E9Q512|E9Q512_MOUSE sp|P62301|RS13_MOUSE sp|Q9QY76|VAPB_MOUSE sp|Q61599|GDIR2_MOUSE sp|Q64133|AOFA_MOUSE sp|A2AGT5|CKAP5_MOUSE sp|P57784|RU2A_MOUSE tr|Q9CZN7|Q9CZN7_MOUSE sp|Q9ERK4|XPO2_MOUSE sp|Q6PDQ2|CHD4_MOUSE sp|P58044|IDI1_MOUSE sp|Q2TPA8|HSDL2_MOUSE sp|P26516|PSMD7_MOUSE sp|P10639|THIO_MOUSE sp|P05132|KAPCA_MOUSE sp|Q62448|IF4G2_MOUSE sp|O88477|IF2B1_MOUSE sp|Q91VR5|DDX1_MOUSE tr|E9Q7G0|E9Q7G0_MOUSE sp|Q9EQU5|SET_MOUSE sp|Q9ESZ8|GTF2I_MOUSE sp|Q9R0E2|PLOD1_MOUSE sp|P35486|ODPA_MOUSE sp|Q80UM3|NAA15_MOUSE
971.518 1220.86 956.563 979.727 986.097 1355.3 916.569 1155.38 957.132 959.037 1322.39 789.129 1150.58 837.831 877.37 1274.32 1004.56 1574.89 683.601 931.869 879.545 760.234 945.223 867.485 697.985 869.175 683.145 1343.14 727.577 1300.63 987.018 1045.13 1038.85 1188.74 942.245 844.773 1128.2 992.045 855.561 1036.4 742.744 1514.29 1075.52 1004.41 782.943 961.497 1182.84 1033.08 1423.35 807.737 792.964 689.885 1217.72 813.606 921.027 758.568 762.174 1345.19 816.142 976.556 594.886 1307.7
346.827 876.242 493.655 1316.07 1735.24 1223.78 620.079 875.248 783.656 1180.98 1379.47 871.604 1966.31 1004.37 1592.63 1459.45 1107.21 647.434 1480.92 1348.66 1352.58 676.387 1317.98 595.597 793.101 1500.53 1690.15 1037.96 2976.67 1752.03 765.042 426.734 564.526 1177.32 964.957 872.484 1400.85 1133.32 986.734 1199.98 1089.1 1564.29 1531.97 1177.58 987.098 1397.75 1326.83 1006.39 542.772 681.242 1065.76 1803.34 1282.59 1589.2 1023.34 1023.09 1312.48 1035.25 675.145 926.856 1530.25 1215.45
1246.02 818.137 468.995 1550.29 1474.51 1024.7 343.556 842.966 925.816 887.907 848.022 711.179 1549.45 903.324 1778.19 1473.71 1139.55 1646.25 3875.34 1005.6 1721.9 1634.21 1023.45 1120.88 1398.41 2486.54 1402.86 738.168 643.603 3146.5 1155.21 726.981 1192.71 1650.55 1275.17 1487.93 1626.96 932.465 1654.58 729.345 2483.71 2279.79 936.615 1027.66 1406.21 951.267 965.798 1058.25 883.046 1461.63 785.802 4058.57 1283.96 1282.4 1373.49 1123.36 1724.04 1515.43 1124.42 420.557 3228.53 1016.2
1.23 1.21 1.17 1.16 1.16 1.15 1.14 1.12 1.11 1.11 1.11 1.09 1.07 1.06 1.04 1.00 1.00 1.00 1.00 0.99 0.98 0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.94 0.93 0.91 0.89 0.88 0.87 0.87 0.86 0.83 0.80 0.74 1.54 1.34 1.33 1.32 1.27 1.26 1.22 1.22 1.21 1.20 1.17 1.15 1.14 1.13 1.12 1.09 1.09 1.09 1.07 1.06 1.05 1.04 1.03
0.99 0.77 0.51 1.50 1.59 0.91 0.54 0.77 0.97 1.05 0.84 1.00 1.68 1.08 1.78 1.18 0.98 0.69 3.73 1.03 1.59 1.30 1.16 0.91 1.31 2.19 1.91 0.57 2.17 1.77 0.81 0.44 0.69 0.91 0.94 1.08 1.18 0.78 1.02 1.12 2.53 1.67 1.46 1.19 1.67 1.28 1.21 1.24 0.63 1.40 1.14 5.15 1.11 1.86 1.32 1.30 1.95 1.09 0.99 0.63 3.64 0.91
ACCEPTED MANUSCRIPT
TE D
1382.98 1011.31 594.529 1042.44 1013.14 1587.51 1044.2 1421.57 1138.96 1292.88 635.649 1134.34 689.8 880.916 1212.16 1059.76 1034.4 1159.57 465.18 936.166 670.12 1008.26 456.962 891.561 656.068 785.824 596.17 965.669 1320.45 988.823 717.187 1050.51 678.873 658.175 641.008 667.898 1042.32 921.957 1297.51 923.892 1217.48 1460.28 1504.02 876.504 659.382 1172.54 923.192 824.772 616.96 1038.73 940.864 1137.98 703.792 997.116 866.033 390.1 854.442 598.589 486.635 573.853 756.136 694.183
1295.97 1360.63 845.447 1120.92 1194.28 1221.06 1082.77 1167.89 1212.92 1293.39 660.49 1115.33 698.252 787.015 949.946 1125.16 867.228 1959.94 898.381 1402.21 1139.37 1547.58 575.264 1186.64 815.019 1212.91 891.288 915.68 1533.8 1213.46 776.141 1260.83 862.873 823.174 841.817 791.487 1246.36 825.338 1066.42 1018.66 1398.58 1365.13 1322.61 944.579 612.225 1184.78 834.8 942.976 715.692 1019.43 920.219 1224.52 631.105 858.21 747.21 1589.35 1003.54 1010.14 779.686 658.141 1104 1153.85
RI PT
1193.34 1215.82 787.73 1044.5 1188.47 1193.09 968.918 1187.47 1227.1 1347.89 691.287 1523.7 810.028 1011.83 812.489 1198.11 897.347 958.005 519.632 993.015 846.016 1163.84 397.067 1017.61 619.014 970.824 747.425 813.97 1300.78 1138.84 698.338 1066.11 797.578 707.015 709.193 648.968 1198.63 756.704 1113.32 956.13 1172.74 1181.7 1224.6 906.448 743.112 1330.02 757.923 1001.5 769.192 924.374 987.151 1435.24 690.011 865.397 893.547 915.845 652.231 660.28 511.771 560.944 913.813 925.765
SC
19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 17 17 17 17 17 17 17
M AN U
NPC2_MOUSE Epididymal secretory protein E1 RAN_MOUSE GTP-binding nuclear protein Ran BPHL_MOUSE Valacyclovir hydrolase ZN638_MOUSE Zinc finger protein 638 FCL_MOUSE GDP-L-fucose synthase CAPR1_MOUSE Caprin-1 CE170_MOUSE Centrosomal protein of 170 kDa RL27A_MOUSE 60S ribosomal protein L27a NDUA5_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 PRDX3_MOUSE Thioredoxin-dependent peroxide reductase, mitochondrial STML2_MOUSE Stomatin-like protein 2, mitochondrial ATP5I_MOUSE ATP synthase subunit e, mitochondrial CSN4_MOUSE COP9 signalosome complex subunit 4 RL32_MOUSE 60S ribosomal protein L32 CDC37_MOUSE Hsp90 co-chaperone Cdc37 H3BL37_MOUSE Treacle protein TB182_MOUSE 182 kDa tankyrase-1-binding protein ATP5L_MOUSE ATP synthase subunit g, mitochondrial LIPS_MOUSE Hormone-sensitive lipase PEPL1_MOUSE Probable aminopeptidase NPEPL1 TRNT1_MOUSE CCA tRNA nucleotidyltransferase 1, mitochondrial ITB1_MOUSE Integrin beta-1 TAGL2_MOUSE Transgelin-2 MA2A1_MOUSE Alpha-mannosidase 2 TIM13_MOUSE Mitochondrial import inner membrane translocase subunit Tim13 MUC18_MOUSE Cell surface glycoprotein MUC18 SYCC_MOUSE Cysteine--tRNA ligase, cytoplasmic RS16_MOUSE 40S ribosomal protein S16 GYS1_MOUSE Glycogen [starch] synthase, muscle ACOX3_MOUSE Peroxisomal acyl-coenzyme A oxidase 3 GUAA_MOUSE GMP synthase [glutamine-hydrolyzing] ERP44_MOUSE Endoplasmic reticulum resident protein 44 RADI_MOUSE Radixin DC1L1_MOUSE Cytoplasmic dynein 1 light intermediate chain 1 C1TM_MOUSE Monofunctional C1-tetrahydrofolate synthase, mitochondrial HMGB2_MOUSE High mobility group protein B2 NDUAA_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial SF01_MOUSE Splicing factor 1 RL24_MOUSE 60S ribosomal protein L24 SLK_MOUSE STE20-like serine/threonine-protein kinase KAD3_MOUSE GTP:AMP phosphotransferase AK3, mitochondrial FKBP3_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP3 EIF3G_MOUSE Eukaryotic translation initiation factor 3 subunit G FMR1_MOUSE Fragile X mental retardation protein 1 homolog CPNS1_MOUSE Calpain small subunit 1 DHI1_MOUSE Corticosteroid 11-beta-dehydrogenase isozyme 1 NSF1C_MOUSE NSFL1 cofactor p47 SNX2_MOUSE Sorting nexin-2 TMLH_MOUSE Trimethyllysine dioxygenase, mitochondrial MESD_MOUSE LDLR chaperone MESD TCRG1_MOUSE Transcription elongation regulator 1 STA5A_MOUSE Signal transducer and activator of transcription 5A BLVRB_MOUSE Flavin reductase (NADPH) GOGA2_MOUSE Golgin subfamily A member 2 COR1B_MOUSE Coronin-1B CO1A2_MOUSE Collagen alpha-2(I) chain SRRM2_MOUSE Serine/arginine repetitive matrix protein 2 RAC1_MOUSE Ras-related C3 botulinum toxin substrate 1 VAPA_MOUSE Vesicle-associated membrane protein-associated protein A AP2A2_MOUSE AP-2 complex subunit alpha-2 DHX9_MOUSE Isoform 2 of ATP-dependent RNA helicase A VWA8_MOUSE von Willebrand factor A domain-containing protein 8
EP
Npc2 Ran Bphl Znf638 Tsta3 Caprin1 Cep170 Rpl27a Ndufa5 Prdx3 Stoml2 Atp5i Cops4 Rpl32 Cdc37 Tcof1 Tnks1bp1 Atp5l Lipe Npepl1 Trnt1 Itgb1 Tagln2 Man2a1 Timm13 Mcam Cars Rps16 Gys1 Acox3 Gmps Erp44 Rdx Dync1li1 Mthfd1l Hmgb2 Ndufa10 Sf1 Rpl24 Slk Ak3 Fkbp3 Eif3g Fmr1 Capns1 Hsd11b1 Nsfl1c Snx2 Tmlhe Mesdc2 Tcerg1 Stat5a Blvrb Golga2 Coro1b Col1a2 Srrm2 Rac1 Vapa Ap2a2 Dhx9 Vwa8
AC C
sp|Q9Z0J0|NPC2_MOUSE sp|P62827|RAN_MOUSE sp|Q8R164|BPHL_MOUSE sp|Q61464|ZN638_MOUSE sp|P23591|FCL_MOUSE sp|Q60865|CAPR1_MOUSE sp|Q6A065|CE170_MOUSE sp|P14115|RL27A_MOUSE sp|Q9CPP6|NDUA5_MOUSE sp|P20108|PRDX3_MOUSE sp|Q99JB2|STML2_MOUSE sp|Q06185|ATP5I_MOUSE sp|O88544|CSN4_MOUSE sp|P62911|RL32_MOUSE sp|Q61081|CDC37_MOUSE tr|H3BL37|H3BL37_MOUSE sp|P58871|TB182_MOUSE sp|Q9CPQ8|ATP5L_MOUSE sp|P54310|LIPS_MOUSE sp|Q6NSR8|PEPL1_MOUSE sp|Q8K1J6|TRNT1_MOUSE sp|P09055|ITB1_MOUSE sp|Q9WVA4|TAGL2_MOUSE sp|P27046|MA2A1_MOUSE sp|P62075|TIM13_MOUSE sp|Q8R2Y2|MUC18_MOUSE sp|Q9ER72|SYCC_MOUSE sp|P14131|RS16_MOUSE sp|Q9Z1E4|GYS1_MOUSE sp|Q9EPL9|ACOX3_MOUSE sp|Q3THK7|GUAA_MOUSE sp|Q9D1Q6|ERP44_MOUSE sp|P26043|RADI_MOUSE sp|Q8R1Q8|DC1L1_MOUSE sp|Q3V3R1|C1TM_MOUSE sp|P30681|HMGB2_MOUSE sp|Q99LC3|NDUAA_MOUSE sp|Q64213|SF01_MOUSE sp|Q8BP67|RL24_MOUSE sp|O54988|SLK_MOUSE sp|Q9WTP7|KAD3_MOUSE sp|Q62446|FKBP3_MOUSE sp|Q9Z1D1|EIF3G_MOUSE sp|P35922|FMR1_MOUSE sp|O88456|CPNS1_MOUSE sp|P50172|DHI1_MOUSE sp|Q9CZ44|NSF1C_MOUSE sp|Q9CWK8|SNX2_MOUSE sp|Q91ZE0|TMLH_MOUSE sp|Q9ERE7|MESD_MOUSE sp|Q8CGF7|TCRG1_MOUSE sp|P42230|STA5A_MOUSE sp|Q923D2|BLVRB_MOUSE sp|Q921M4|GOGA2_MOUSE sp|Q9WUM3|COR1B_MOUSE sp|Q01149|CO1A2_MOUSE sp|Q8BTI8|SRRM2_MOUSE sp|P63001|RAC1_MOUSE sp|Q9WV55|VAPA_MOUSE sp|P17427|AP2A2_MOUSE sp|O70133-2|DHX9_MOUSE sp|Q8CC88|VWA8_MOUSE
1358.49 923.378 548.846 960.769 991.434 1514.16 866.215 1297.51 1020.98 1195.08 582.218 1345.11 681.566 905.979 823.135 822.995 753.678 1447.74 572.522 1304.7 747.768 1124.43 465.376 1075.5 679.84 838.141 658.999 1127.33 1399.14 1109.49 759.195 1011.57 717.636 637.483 597.253 595.785 1110.28 909.296 1382.68 886.012 1018.59 1304.08 1359.53 798.636 744.72 1223.82 777.416 787.551 572.516 786.747 771.833 1009.06 553.95 725.194 738.124 567.481 1116.17 690.373 524.944 792.767 1013.7 856.045
775.025 1684.09 690.853 701.361 1105.64 817.406 1019.94 1374.63 1070.25 1194.11 943.925 887.117 1449.13 1925.57 1004.24 426.895 639.722 1068.68 1164.57 731.985 915.737 1514.29 879.831 1070.16 514.988 456.999 1014.45 1100.19 632.138 1323.41 1750.02 784.225 851.172 828.043 1213.86 1362.4 1056.93 732.34 1399.73 1168.35 878.592 1180.81 1241.23 623.304 1233.57 661.238 677.749 889.271 725.083 1034.5 1009.5 931.323 722.266 668.178 916.455 418.642 596.361 2370.28 1092.87 1076.34 1082.1 694.786
1060.12 1488.74 897.305 1680.86 1074.71 2258.14 1182.6 2482.22 1808.99 1899.56 923.754 1066.68 1242.98 2795.87 1244.57 819.921 1416.31 1007.55 1597.43 947.01 782.09 903.808 1075.03 763.268 1230.75 699.621 610.188 1057.32 491.437 902.706 1668.79 1140.12 690.931 875.263 1064.03 2032 1163.85 1408.42 2673.24 1529.32 1830.31 2095.16 2284.78 784.509 1293.03 532.62 1158.97 872.829 1149.91 1836.44 1203.35 908.728 1591.77 1230.2 1229.1 384.401 1558.54 1553.02 1793.35 1169.57 1295.51 1263.77
1.03 1.03 1.01 1.00 0.99 0.98 0.97 0.94 0.94 0.94 0.94 0.93 0.92 0.89 0.88 0.86 0.84 1.61 1.49 1.40 1.24 1.23 1.22 1.18 1.17 1.17 1.15 1.15 1.12 1.09 1.08 1.07 1.07 1.07 1.07 1.05 1.05 1.03 1.02 1.01 1.01 1.01 0.98 0.98 0.97 0.96 0.96 0.95 0.93 0.92 0.88 0.87 0.85 0.85 0.84 1.65 1.41 1.35 1.31 1.28 1.27 1.24
0.71 1.42 1.15 1.14 0.99 1.11 1.09 1.48 1.22 1.17 1.41 0.74 1.79 2.49 1.11 0.55 1.06 0.98 2.80 0.87 1.12 1.11 2.29 0.96 1.37 0.66 1.21 1.21 0.43 1.05 2.42 0.91 1.04 1.25 1.69 2.58 0.99 1.28 1.69 1.43 1.13 1.24 1.29 0.79 1.80 0.48 1.09 0.96 1.35 1.46 1.15 0.72 1.66 1.02 1.22 0.61 1.43 3.12 2.89 1.98 1.42 1.21
ACCEPTED MANUSCRIPT
778.537 510.883 545.343 853.623 792.179 749.804 917.946 1070.7 1168.53 788.49 563.468 745.125 1070.42 1590.88 515.487 1000.57 967.976 901.779 583.342 927.806 786.131 950.327 706.585 971.109 740.61 1164.21 709.326 871.797 917.125 927.016 994.127 1140.48 726.281 719.339 612.297 832.159 1171.4 690.067 1014.43 1073.51 1421.26 579.089 526.761 781.752 816.2 722.709 484.301 911.235 675.603 933.611 985.128 860.811 804.894 1054.98 668.459 723.116 713.825 648.908 835.46 818.958 646.184 706.208
912.123 720.561 592.101 1131.52 1194.22 985.879 1344.04 1431.78 1378.3 905.876 727.81 980.415 1300.41 1518.46 661.655 1204.5 1104.87 1117.17 721.219 954.09 932.369 989.251 820.498 1123.66 868.651 1060.59 844.882 888.148 1012.16 923.083 887.489 999.76 656.467 744.716 700.612 908.575 1091.95 618.499 902.327 1009.43 615.434 1268.09 860.061 1291.21 948.14 889.846 740.138 1246.75 1078.31 1199.71 1223.84 1203.32 1023.17 1649.77 829.994 965.029 997.033 642.396 1080.36 1036.32 702.119 815.262
RI PT
687.623 517.457 503.566 953.096 975.007 887.045 1216.84 1311.25 1360.39 878.533 612.045 878.26 1190.09 1366.16 654.162 1187.79 997.673 1177.22 770.893 905.837 934.183 930.989 785.983 1114.32 924.713 973.128 854.47 991.893 1007.75 888.734 980.655 1011.15 844.529 735.574 794.413 1015.2 1031.53 666.825 1010.9 1205.38 1716.87 672.282 628.077 916.591 632.54 679.523 584.412 1016 888.808 1017.64 955.653 1010.75 775.762 1168.54 691.919 847.242 853.211 551.416 961.9 918.283 692.834 715.281
SC
17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16
M AN U
TE D
Dpp3 Got1 Ik Ilf3 Nutf2 Matr3 Cryz Psma6 Pdap1 Tns1 Usp47 Pabpc4 Qki Rpl26 Cfl2 Sf3b3 Fam129b Hars Sf3a3 Naca Ssbp1 Pak2 Ca5b Fam213a Papss2 Pon2 Mars Sar1b Rap1a Acta2 Ddx6 Ndufs2 Cul3 Bzw2 Samhd1 Myl12a Psma1 Cops3 Capn1 Psma7 Palm Ptbp1 Afg3l2 Fermt2 Ap2b1
ECM29_MOUSE Proteasome-associated protein ECM29 homolog CY1_MOUSE Cytochrome c1, heme protein, mitochondrial IMB1_MOUSE Importin subunit beta-1 TMX3_MOUSE Protein disulfide-isomerase TMX3 ARLY_MOUSE Argininosuccinate lyase ASSY_MOUSE Argininosuccinate synthase Q921K2_MOUSE Poly (ADP-ribose) polymerase family, member 1 LAMP1_MOUSE Lysosome-associated membrane glycoprotein 1 LKHA4_MOUSE Leukotriene A-4 hydrolase SNAA_MOUSE Alpha-soluble NSF attachment protein PLPL8_MOUSE Calcium-independent phospholipase A2-gamma SEP11_MOUSE Septin-11 PRUNE_MOUSE Protein prune homolog FKB10_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP10 ARP2_MOUSE Actin-related protein 2 PPME1_MOUSE Protein phosphatase methylesterase 1 CN166_MOUSE UPF0568 protein C14orf166 homolog DPP3_MOUSE Dipeptidyl peptidase 3 AATC_MOUSE Aspartate aminotransferase, cytoplasmic RED_MOUSE Protein Red ILF3_MOUSE Interleukin enhancer-binding factor 3 NTF2_MOUSE Nuclear transport factor 2 MATR3_MOUSE Matrin-3 QOR_MOUSE Quinone oxidoreductase PSA6_MOUSE Proteasome subunit alpha type-6 HAP28_MOUSE 28 kDa heat- and acid-stable phosphoprotein E9Q0S6_MOUSE Protein Tns1 UBP47_MOUSE Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 47 A3KFU5_MOUSE Protein Pabpc4 QKI_MOUSE Protein quaking RL26_MOUSE 60S ribosomal protein L26 COF2_MOUSE Cofilin-2 SF3B3_MOUSE Splicing factor 3B subunit 3 NIBL1_MOUSE Niban-like protein 1 SYHC_MOUSE Histidine--tRNA ligase, cytoplasmic SF3A3_MOUSE Splicing factor 3A subunit 3 NACAM_MOUSE Nascent polypeptide-associated complex subunit alpha, muscle-specific form Q8R2K3_MOUSE Single-stranded DNA-binding protein PAK2_MOUSE Serine/threonine-protein kinase PAK 2 CAH5B_MOUSE Carbonic anhydrase 5B, mitochondrial F213A_MOUSE Redox-regulatory protein FAM213A PAPS2_MOUSE Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 PON2_MOUSE Serum paraoxonase/arylesterase 2 SYMC_MOUSE Methionine--tRNA ligase, cytoplasmic SAR1B_MOUSE GTP-binding protein SAR1b RAP1A_MOUSE Ras-related protein Rap-1A ACTA_MOUSE Actin, aortic smooth muscle DDX6_MOUSE Probable ATP-dependent RNA helicase DDX6 NDUS2_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial CUL3_MOUSE Cullin-3 BZW2_MOUSE Basic leucine zipper and W2 domain-containing protein 2 SAMH1_MOUSE Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q6ZWQ9_MOUSE MCG5400 PSA1_MOUSE Proteasome subunit alpha type-1 CSN3_MOUSE COP9 signalosome complex subunit 3 CAN1_MOUSE Calpain-1 catalytic subunit PSA7_MOUSE Proteasome subunit alpha type-7 PALM_MOUSE Paralemmin-1 Q8BGJ5_MOUSE MCG13402, isoform CRA_a AFG32_MOUSE AFG3-like protein 2 FERM2_MOUSE Fermitin family homolog 2 AP2B1_MOUSE AP-2 complex subunit beta
EP
Ecm29 Cyc1 Kpnb1 Tmx3 Asl Ass1 Parp1 Lamp1 Lta4h Napa Pnpla8 septin11 Prune Fkbp10 Actr2 Ppme1
AC C
sp|Q6PDI5|ECM29_MOUSE sp|Q9D0M3|CY1_MOUSE sp|P70168|IMB1_MOUSE sp|Q8BXZ1|TMX3_MOUSE sp|Q91YI0|ARLY_MOUSE sp|P16460|ASSY_MOUSE tr|Q921K2|Q921K2_MOUSE sp|P11438|LAMP1_MOUSE sp|P24527|LKHA4_MOUSE sp|Q9DB05|SNAA_MOUSE sp|Q8K1N1|PLPL8_MOUSE sp|Q8C1B7|SEP11_MOUSE sp|Q8BIW1|PRUNE_MOUSE sp|Q61576|FKB10_MOUSE sp|P61161|ARP2_MOUSE sp|Q8BVQ5|PPME1_MOUSE sp|Q9CQE8|CN166_MOUSE sp|Q99KK7|DPP3_MOUSE sp|P05201|AATC_MOUSE sp|Q9Z1M8|RED_MOUSE sp|Q9Z1X4|ILF3_MOUSE sp|P61971|NTF2_MOUSE sp|Q8K310|MATR3_MOUSE sp|P47199|QOR_MOUSE sp|Q9QUM9|PSA6_MOUSE sp|Q3UHX2|HAP28_MOUSE tr|E9Q0S6|E9Q0S6_MOUSE sp|Q8BY87-2|UBP47_MOUSE tr|A3KFU5|A3KFU5_MOUSE sp|Q9QYS9|QKI_MOUSE sp|P61255|RL26_MOUSE sp|P45591|COF2_MOUSE sp|Q921M3|SF3B3_MOUSE sp|Q8R1F1|NIBL1_MOUSE sp|Q61035|SYHC_MOUSE sp|Q9D554|SF3A3_MOUSE sp|P70670|NACAM_MOUSE tr|Q8R2K3|Q8R2K3_MOUSE sp|Q8CIN4|PAK2_MOUSE sp|Q9QZA0|CAH5B_MOUSE sp|Q9CYH2|F213A_MOUSE sp|O88428|PAPS2_MOUSE sp|Q62086|PON2_MOUSE sp|Q68FL6|SYMC_MOUSE sp|Q9CQC9|SAR1B_MOUSE sp|P62835|RAP1A_MOUSE sp|P62737|ACTA_MOUSE sp|P54823|DDX6_MOUSE sp|Q91WD5|NDUS2_MOUSE sp|Q9JLV5|CUL3_MOUSE sp|Q91VK1|BZW2_MOUSE sp|Q60710|SAMH1_MOUSE tr|Q6ZWQ9|Q6ZWQ9_MOUSE sp|Q9R1P4|PSA1_MOUSE sp|O88543|CSN3_MOUSE sp|O35350|CAN1_MOUSE sp|Q9Z2U0|PSA7_MOUSE sp|Q9Z0P4|PALM_MOUSE tr|Q8BGJ5|Q8BGJ5_MOUSE sp|Q8JZQ2|AFG32_MOUSE sp|Q8CIB5|FERM2_MOUSE sp|Q9DBG3|AP2B1_MOUSE
904.729 541.558 644.59 963.919 823.625 867.731 1040.58 1212.83 1418.6 915.423 539.995 758.766 1030.05 1522.6 523.158 988.57 849.461 945.984 621.878 862.704 765.215 859.466 642.744 900.373 742.247 988.925 654.588 889.749 807.543 782.138 962.983 1004.02 798.227 600.953 591.882 751.326 879.798 557.768 839.274 723.767 422.211 888.337 726.491 911.232 922.446 859.732 554.367 1045.68 781.041 1101.12 1059.51 958.991 801.457 897.086 688.244 777.569 715.594 648.427 851.529 822.495 723.579 697.161
1239.25 708.355 1441.34 929.768 881.083 1341.56 785.499 1065.74 1185.44 1223.3 900.782 917.009 1260.62 936.209 798.79 1574.72 1082.44 677.28 1324.02 640.414 950.717 697.435 603.501 775.855 838.983 598.576 643.613 1030.46 600.952 622.053 715.197 1031.75 600.798 1104.64 920.112 1074.56 780.248 630.001 903.916 700.839 2552.79 692.874 534.221 1042.38 792.554 1461.34 538.813 945.139 878.931 1150.56 1290.09 1102.71 868.077 1055.53 1417.7 1093.27 855.416 503.501 933.312 708.192 935.296 929.743
950.492 700.055 783.877 611.538 559.882 989.763 924.858 934.565 1015.18 1229.75 997.97 945.719 1306.6 1203.67 560.88 1558.42 1233.68 759.798 873.144 1016.27 1169.64 1275.42 1003.2 1362.91 765.161 1211.02 1191.63 1277.37 1172.58 1233.24 1251.51 2055.11 483.191 885.803 802.34 1012.69 1666.07 1080.31 1266.71 1978.86 2416.84 826.261 555.04 829.486 928.931 1263.44 556.508 728.737 731.522 686.294 1346.51 1339.56 1861.19 1267.37 1023.55 845.572 740.551 723.282 925.467 826.105 723.737 1024.61
1.24 1.23 1.18 1.16 1.14 1.13 1.12 1.11 1.11 1.09 1.08 1.07 1.03 1.03 1.01 1.00 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.97 0.97 0.96 0.96 0.95 0.95 0.94 0.94 0.93 0.93 0.92 0.92 0.90 0.90 0.87 0.86 0.76 0.33 1.72 1.37 1.30 1.29 1.25 1.21 1.19 1.19 1.18 1.18 1.16 1.15 1.15 1.12 1.11 1.09 1.08 1.07 1.07 1.06 1.06
1.49 1.37 2.12 0.85 0.82 1.42 0.80 0.84 0.87 1.47 1.62 1.15 1.14 0.72 1.16 1.43 1.18 0.69 1.62 0.90 1.23 1.05 1.08 1.03 0.96 0.85 1.17 1.24 0.92 1.02 1.00 1.43 0.69 1.37 1.22 1.13 1.11 1.26 1.07 1.18 1.58 1.21 0.94 1.10 1.19 1.94 1.02 0.87 1.03 0.94 1.36 1.30 1.73 1.04 1.79 1.23 1.02 1.02 1.03 0.88 1.24 1.37
ACCEPTED MANUSCRIPT
TE D
1027.52 491.497 940.919 1048.72 554.458 683.602 817.329 630.732 793.348 852.656 934.437 1343.61 553.135 783.483 706.87 735.764 515.732 944.108 1026.16 723.08 865.728 716.091 798.664 1050.28 647.84 888.782 793.263 1018.31 908.82 913.95 840.291 953.684 420.311 587.054 502.144 807.717 991.172 928.478 706.228 807.231 644.843 599.813 723.416 581.113 550.929 845.671 763.739 715.183 908.613 485.895 720.152 677.401 557.156 743.191 638.037 921.551 713.024 827.342 930.929 569.922 623.689 678.381
1386.3 583.438 782.516 1108.32 677.042 848.708 904.73 749.537 816.244 922.804 974.191 1020.87 612.092 847.894 753.465 908.528 599.259 855.889 989.171 759.632 817.883 873.774 1083.65 785.882 627.6 1008.75 780.538 1084.38 779.659 756.412 1616.95 1465.03 815.939 1028.39 846.307 1263.41 986.596 1124.65 1080.89 1005.9 815.154 778.153 1006.17 736.343 690.942 1087.77 848.927 864.781 925.676 694.12 959.759 886.485 589.287 753.157 778.668 818.165 786.736 756.67 924.843 673.944 772.5 737.624
RI PT
1265.6 468.443 869.134 997.493 590.086 818.575 855.751 686.305 813.072 806.815 885.969 702.655 572.547 715.268 750.933 903.64 633.787 825.29 896.014 819.742 847.647 913.319 1215.63 799.631 685.15 1022 734.963 1425.07 912.217 1024.38 726.667 796.014 482.582 572.032 547.784 894.226 840.362 898.925 833.3 886.629 679.227 648.136 787.762 604.974 574.203 931.009 660.315 716.259 777.049 559.713 873.611 781.059 480.526 637.845 676.879 892.624 798.406 648.951 911.416 609.781 734.629 769.602
SC
16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15
M AN U
YMEL1_MOUSE ATP-dependent zinc metalloprotease YME1L1 ATPD_MOUSE ATP synthase subunit delta, mitochondrial ABCD3_MOUSE ATP-binding cassette sub-family D member 3 RT31_MOUSE 28S ribosomal protein S31, mitochondrial TPD54_MOUSE Tumor protein D54 ESYT1_MOUSE Extended synaptotagmin-1 PDXD1_MOUSE Pyridoxal-dependent decarboxylase domain-containing protein 1 HMGB3_MOUSE High mobility group protein B3 ARPC2_MOUSE Actin-related protein 2/3 complex subunit 2 AAKB1_MOUSE 5'-AMP-activated protein kinase subunit beta-1 LZTL1_MOUSE Leucine zipper transcription factor-like protein 1 H2B1M_MOUSE Histone H2B type 1-M CHCH3_MOUSE Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial F162A_MOUSE Protein FAM162A RL22_MOUSE 60S ribosomal protein L22 ROCK2_MOUSE Rho-associated protein kinase 2 MTX2_MOUSE Metaxin-2 PFD5_MOUSE Prefoldin subunit 5 EI3JA_MOUSE Eukaryotic translation initiation factor 3 subunit J-A OXSR1_MOUSE Serine/threonine-protein kinase OSR1 ANXA4_MOUSE Annexin A4 APEH_MOUSE Acylamino-acid-releasing enzyme BGLR_MOUSE Beta-glucuronidase TR150_MOUSE Thyroid hormone receptor-associated protein 3 PIPNB_MOUSE Phosphatidylinositol transfer protein beta isoform PPGB_MOUSE Lysosomal protective protein BT3L4_MOUSE Transcription factor BTF3 homolog 4 MA2B1_MOUSE Lysosomal alpha-mannosidase PPM1G_MOUSE Protein phosphatase 1G GPAT3_MOUSE Glycerol-3-phosphate acyltransferase 3 GSTM2_MOUSE Glutathione S-transferase Mu 2 D3Z6I7_MOUSE Protein Cald1 AT1A1_MOUSE Sodium/potassium-transporting ATPase subunit alpha-1 TPM1_MOUSE Tropomyosin alpha-1 chain SEC63_MOUSE Translocation protein SEC63 homolog CUL4B_MOUSE Cullin-4B IPO5_MOUSE Importin-5 CP51A_MOUSE Lanosterol 14-alpha demethylase IDE_MOUSE Insulin-degrading enzyme UGDH_MOUSE UDP-glucose 6-dehydrogenase AP3B1_MOUSE AP-3 complex subunit beta-1 BASI_MOUSE Basigin K6PL_MOUSE 6-phosphofructokinase, liver type RL14_MOUSE 60S ribosomal protein L14 TNPO1_MOUSE Transportin-1 CUL4A_MOUSE Cullin-4A EM55_MOUSE 55 kDa erythrocyte membrane protein ACTZ_MOUSE Alpha-centractin LASP1_MOUSE LIM and SH3 domain protein 1 PGRC2_MOUSE Membrane-associated progesterone receptor component 2 RAGP1_MOUSE Ran GTPase-activating protein 1 P5CS_MOUSE Delta-1-pyrroline-5-carboxylate synthase NDKA_MOUSE Nucleoside diphosphate kinase A RCN2_MOUSE Reticulocalbin-2 GCP60_MOUSE Golgi resident protein GCP60 RS9_MOUSE 40S ribosomal protein S9 EIF3E_MOUSE Eukaryotic translation initiation factor 3 subunit E UBP2L_MOUSE Ubiquitin-associated protein 2-like NNRE_MOUSE NAD(P)H-hydrate epimerase LMAN1_MOUSE Protein ERGIC-53 PTN11_MOUSE Tyrosine-protein phosphatase non-receptor type 11 ATG7_MOUSE Ubiquitin-like modifier-activating enzyme ATG7
EP
Yme1l1 Atp5d Abcd3 Mrps31 Tpd52l2 Esyt1 Pdxdc1 Hmgb3 Arpc2 Prkab1 Lztfl1 Hist1h2bm Chchd3 Fam162a Rpl22 Rock2 Mtx2 Pfdn5 Eif3j1 Oxsr1 Anxa4 Apeh Gusb Thrap3 Pitpnb Ctsa Btf3l4 Man2b1 Ppm1g Agpat9 Gstm2 Cald1 Atp1a1 Tpm1 Sec63 Cul4b Ipo5 Cyp51a1 Ide Ugdh Ap3b1 Bsg Pfkl Rpl14 Tnpo1 Cul4a Mpp1 Actr1a Lasp1 Pgrmc2 Rangap1 Aldh18a1 Nme1 Rcn2 Acbd3 Rps9 Eif3e Ubap2l Apoa1bp Lman1 Ptpn11 Atg7
AC C
sp|O88967|YMEL1_MOUSE sp|Q9D3D9|ATPD_MOUSE sp|P55096|ABCD3_MOUSE sp|Q61733|RT31_MOUSE sp|Q9CYZ2|TPD54_MOUSE sp|Q3U7R1|ESYT1_MOUSE sp|Q99K01|PDXD1_MOUSE sp|O54879|HMGB3_MOUSE sp|Q9CVB6|ARPC2_MOUSE sp|Q9R078|AAKB1_MOUSE sp|Q9JHQ5|LZTL1_MOUSE sp|P10854|H2B1M_MOUSE sp|Q9CRB9|CHCH3_MOUSE sp|Q9D6U8|F162A_MOUSE sp|P67984|RL22_MOUSE sp|P70336|ROCK2_MOUSE sp|O88441|MTX2_MOUSE sp|Q9WU28|PFD5_MOUSE sp|Q3UGC7|EI3JA_MOUSE sp|Q6P9R2|OXSR1_MOUSE sp|P97429|ANXA4_MOUSE sp|Q8R146|APEH_MOUSE sp|P12265|BGLR_MOUSE sp|Q569Z6|TR150_MOUSE sp|P53811|PIPNB_MOUSE sp|P16675|PPGB_MOUSE sp|Q9CQH7|BT3L4_MOUSE sp|O09159|MA2B1_MOUSE sp|Q61074|PPM1G_MOUSE sp|Q8C0N2|GPAT3_MOUSE sp|P15626|GSTM2_MOUSE tr|D3Z6I7|D3Z6I7_MOUSE sp|Q8VDN2|AT1A1_MOUSE sp|P58771|TPM1_MOUSE sp|Q8VHE0|SEC63_MOUSE sp|A2A432|CUL4B_MOUSE sp|Q8BKC5|IPO5_MOUSE sp|Q8K0C4|CP51A_MOUSE sp|Q9JHR7|IDE_MOUSE sp|O70475|UGDH_MOUSE sp|Q9Z1T1|AP3B1_MOUSE sp|P18572|BASI_MOUSE sp|P12382|K6PL_MOUSE sp|Q9CR57|RL14_MOUSE sp|Q8BFY9|TNPO1_MOUSE sp|Q3TCH7|CUL4A_MOUSE sp|P70290|EM55_MOUSE sp|P61164|ACTZ_MOUSE sp|Q61792|LASP1_MOUSE sp|Q80UU9|PGRC2_MOUSE sp|P46061|RAGP1_MOUSE sp|Q9Z110|P5CS_MOUSE sp|P15532|NDKA_MOUSE sp|Q8BP92|RCN2_MOUSE sp|Q8BMP6|GCP60_MOUSE sp|Q6ZWN5|RS9_MOUSE sp|P60229|EIF3E_MOUSE sp|Q80X50|UBP2L_MOUSE sp|Q8K4Z3|NNRE_MOUSE sp|Q9D0F3|LMAN1_MOUSE sp|P35235|PTN11_MOUSE sp|Q9D906|ATG7_MOUSE
1051.62 435.976 1136.89 1055.3 504.336 701.337 788.734 572.298 795.401 732.754 831.896 1002.09 499.979 631.894 676.407 695.161 515.538 856.779 842.158 701.951 803.527 631.869 763.636 908.675 577.598 706.952 589.85 922.979 664.343 689.534 1186.33 1473.52 591.801 760.633 676.661 974.392 1216.24 1071.04 754.86 1011.4 760.914 689.325 728.446 612.044 587.993 923.452 760.773 744.353 964.326 475.113 783.937 688.693 520.326 710.249 609.146 1081.58 771.06 756.268 936.165 508.603 578.72 699.461
454.75 331.402 1706.27 369.056 392.641 912.479 1284.44 913.819 1407.06 743.234 658.44 1436.98 1018.78 1119.73 1137.76 1200.98 1388.15 991.989 1050.12 781.962 943.332 775.478 788.44 455.377 1063.3 471.994 490.773 575.961 785.987 654.29 1019.8 1138.24 1755.95 816.589 767.375 1804.65 1714.01 279.629 610.455 2477.9 836.649 1355.61 1338.19 2970.15 1564.39 880.235 562.345 1018.09 492.682 568.064 2043.42 1026.63 571.181 486.624 646.332 892.484 789.948 341.73 1487.4 694.658 882.985 1000.25
707.412 714.816 1168.06 1109.49 766.213 1011.53 1216.39 2044.87 1127.8 1222.49 1197.45 1386.1 1390.16 654.417 1298.92 954.039 995.628 1698.89 1846.52 933.025 596.295 915.576 409.986 1109.99 1178.73 721.787 1324.05 697.182 1606.61 570.981 1228.95 1578.98 906.838 1238.61 1048.67 1314.46 1100.23 367.538 636.461 1333.01 844.126 675.294 1163.17 2255.76 826.555 638.66 1655.84 962.356 760.915 404.345 1859.42 627.676 805.106 1290.22 633.75 671.506 647.388 560.876 2042.89 428.665 878.239 855.092
1.06 1.06 1.06 1.06 1.03 1.03 1.01 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.98 0.98 0.97 0.97 0.95 0.95 0.95 0.92 0.92 0.92 0.90 0.90 0.90 0.82 0.79 0.75 1.79 1.68 1.56 1.54 1.45 1.31 1.20 1.20 1.19 1.19 1.19 1.18 1.15 1.14 1.14 1.13 1.13 1.12 1.12 1.12 1.09 1.08 1.07 1.06 1.06 1.05 1.03 1.02 1.01 1.00 0.99 0.99
0.51 1.09 1.59 0.72 1.01 1.28 1.49 2.25 1.58 1.18 1.02 1.38 2.14 1.18 1.67 1.31 2.07 1.52 1.51 1.11 0.90 1.04 0.59 0.85 1.68 0.62 1.19 0.52 1.31 0.63 1.44 1.55 2.95 1.77 1.73 1.83 1.54 0.35 0.81 2.25 1.27 1.63 1.66 4.41 2.13 0.85 1.56 1.38 0.74 0.93 2.45 1.13 1.33 1.29 0.97 0.86 0.95 0.61 1.92 0.95 1.30 1.28
ACCEPTED MANUSCRIPT
943.197 601.801 745.442 813.434 676.441 863.104 760.086 764.552 1007.96 799.446 1040.8 708.573 617.889 719.749 642.416 843.638 1274.86 1275.49 991.278 727.079 917.948 929.475 859.755 642.019 577.24 823.862 1127 1217 473.121 815.144 793.297 744.593 245.146 558.498 1319.4 334.779 415.292 591.682 545.328 569.5 639.715 671.989 431.493 766.855 618.34 658.5 680.702 559.637 577.392 429.418 392.721 462.347 905.627 468.991 633.211 767.072 876.13 795.678 496.388 1323.79 799.601 728.416
818.829 791.795 714.511 869.36 702.607 796.341 1033.59 821.515 964.604 966.999 984.362 700.408 713.689 718.384 617.061 760.941 1270.87 1046.68 885.815 610.729 917.156 899.815 1011.57 577.099 604.089 810.197 961.282 1067.06 444.208 735.838 738.935 652.593 230.949 491.826 799.958 657.394 731.488 1154.77 758.818 686.982 863.955 844.332 577.381 1202.51 727.056 952.956 518.761 752.057 771.928 443.161 327.151 586.674 1249.72 588.961 979.708 907.603 1246.84 1026.29 548.94 1025.55 868.474 956.274
RI PT
742.721 766.857 730.404 863.823 679.957 849.186 1133.68 849.42 960.134 969.652 862.509 649.647 663.8 670.639 571.396 800.213 1285.78 1081.21 851.01 557.183 878.98 1067.82 1055.36 550.794 705.356 846.205 942.36 1305.05 542.243 885.667 782.612 687.239 308.746 527.914 965.407 279.518 369.507 692.249 478.409 457.207 754.142 579.032 450.725 910.02 587.333 728.764 401.508 556.948 532.464 388.237 216.851 556.471 1159.93 432.847 874.989 682.021 1024.56 863.274 476.71 942.405 657.675 789.22
SC
15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14
M AN U
TE D
PGS1_MOUSE Biglycan CO6A2_MOUSE Collagen alpha-2(VI) chain RSSA_MOUSE 40S ribosomal protein SA CDC5L_MOUSE Cell division cycle 5-like protein STK24_MOUSE Serine/threonine-protein kinase 24 ITPA_MOUSE Inosine triphosphate pyrophosphatase PRP19_MOUSE Pre-mRNA-processing factor 19 PURA2_MOUSE Adenylosuccinate synthetase isozyme 2 SMD2_MOUSE Small nuclear ribonucleoprotein Sm D2 MTAP_MOUSE S-methyl-5'-thioadenosine phosphorylase CD2AP_MOUSE CD2-associated protein TMOD3_MOUSE Tropomodulin-3 CD9_MOUSE CD9 antigen UCHL3_MOUSE Ubiquitin carboxyl-terminal hydrolase isozyme L3 MCFD2_MOUSE Multiple coagulation factor deficiency protein 2 homolog CAZA1_MOUSE F-actin-capping protein subunit alpha-1 RBM39_MOUSE RNA-binding protein 39 DNJA2_MOUSE DnaJ homolog subfamily A member 2 F7AA26_MOUSE Protein Palm2Akap2 (Fragment) DNJA1_MOUSE DnaJ homolog subfamily A member 1 SARNP_MOUSE SAP domain-containing ribonucleoprotein CAPZB_MOUSE F-actin-capping protein subunit beta ACSF2_MOUSE Acyl-CoA synthetase family member 2, mitochondrial DENR_MOUSE Density-regulated protein UBA3_MOUSE NEDD8-activating enzyme E1 catalytic subunit GLO2_MOUSE Hydroxyacylglutathione hydrolase, mitochondrial RLA1_MOUSE 60S acidic ribosomal protein P1 LSM2_MOUSE U6 snRNA-associated Sm-like protein LSm2 PP1A_MOUSE Serine/threonine-protein phosphatase PP1-alpha catalytic subunit DDX42_MOUSE ATP-dependent RNA helicase DDX42 Q99LB4_MOUSE Capping protein (Actin filament), gelsolin-like SRBS1_MOUSE Sorbin and SH3 domain-containing protein 1 ESTD_MOUSE S-formylglutathione hydrolase CBR3_MOUSE Carbonyl reductase [NADPH] 3 CHP1_MOUSE Calcineurin B homologous protein 1 BASP1_MOUSE Brain acid soluble protein 1 ISC2A_MOUSE Isochorismatase domain-containing protein 2A, mitochondrial Q9ESU7_MOUSE Neutral amino acid transporter ASCT2 COX5B_MOUSE Cytochrome c oxidase subunit 5B, mitochondrial RL11_MOUSE 60S ribosomal protein L11 ERAP1_MOUSE Endoplasmic reticulum aminopeptidase 1 PPIC_MOUSE Peptidyl-prolyl cis-trans isomerase C PICAL_MOUSE Phosphatidylinositol-binding clathrin assembly protein E9PUM4_MOUSE Talin-2 BZW1_MOUSE Basic leucine zipper and W2 domain-containing protein 1 E9QNL5_MOUSE Sulfotransferase 1A1 H2A2C_MOUSE Histone H2A type 2-C BIRC6_MOUSE Baculoviral IAP repeat-containing protein 6 SRP54_MOUSE Signal recognition particle 54 kDa protein ODBA_MOUSE 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial HMOX1_MOUSE Heme oxygenase 1 ABHD5_MOUSE 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 BGAL_MOUSE Beta-galactosidase CX6B1_MOUSE Cytochrome c oxidase subunit 6B1 LAMA4_MOUSE Laminin subunit alpha-4 MYL9_MOUSE Myosin regulatory light polypeptide 9 MTP_MOUSE Microsomal triglyceride transfer protein large subunit Q91V89_MOUSE Protein Ppp2r5d PCBP1_MOUSE Poly(rC)-binding protein 1 KAP0_MOUSE cAMP-dependent protein kinase type I-alpha regulatory subunit ES1_MOUSE ES1 protein homolog, mitochondrial MP2K1_MOUSE Dual specificity mitogen-activated protein kinase kinase 1
EP
Bgn Col6a2 Rpsa Cdc5l Stk24 Itpa Prpf19 Adss Snrpd2 Mtap Cd2ap Tmod3 Cd9 Uchl3 Mcfd2 Capza1 Rbm39 Dnaja2 Palm2Akap2 Dnaja1 Sarnp Capzb Acsf2 Denr Uba3 Hagh Rplp1 Lsm2 Ppp1ca Ddx42 Capg Sorbs1 Esd Cbr3 Chp1 Basp1 Isoc2a Slc1a5 Cox5b Rpl11 Erap1 Ppic Picalm Tln2 Bzw1 Sult1a1 Hist2h2ac Birc6 Srp54 Bckdha Hmox1 Abhd5 Glb1 Cox6b1 Lama4 Myl9 Mttp Ppp2r5d Pcbp1 Prkar1a D10Jhu81e Map2k1
AC C
sp|P28653|PGS1_MOUSE sp|Q02788|CO6A2_MOUSE sp|P14206|RSSA_MOUSE sp|Q6A068|CDC5L_MOUSE sp|Q99KH8|STK24_MOUSE sp|Q9D892|ITPA_MOUSE sp|Q99KP6|PRP19_MOUSE sp|P46664|PURA2_MOUSE sp|P62317|SMD2_MOUSE sp|Q9CQ65|MTAP_MOUSE sp|Q9JLQ0|CD2AP_MOUSE sp|Q9JHJ0|TMOD3_MOUSE sp|P40240|CD9_MOUSE sp|Q9JKB1|UCHL3_MOUSE sp|Q8K5B2|MCFD2_MOUSE sp|P47753|CAZA1_MOUSE sp|Q8VH51|RBM39_MOUSE sp|Q9QYJ0|DNJA2_MOUSE tr|F7AA26|F7AA26_MOUSE sp|P63037|DNJA1_MOUSE sp|Q9D1J3|SARNP_MOUSE sp|P47757|CAPZB_MOUSE sp|Q8VCW8|ACSF2_MOUSE sp|Q9CQJ6|DENR_MOUSE sp|Q8C878|UBA3_MOUSE sp|Q99KB8|GLO2_MOUSE sp|P47955|RLA1_MOUSE sp|O35900|LSM2_MOUSE sp|P62137|PP1A_MOUSE sp|Q810A7|DDX42_MOUSE tr|Q99LB4|Q99LB4_MOUSE sp|Q62417|SRBS1_MOUSE sp|Q9R0P3|ESTD_MOUSE sp|Q8K354|CBR3_MOUSE sp|P61022|CHP1_MOUSE sp|Q91XV3|BASP1_MOUSE sp|P85094|ISC2A_MOUSE tr|Q9ESU7|Q9ESU7_MOUSE sp|P19536|COX5B_MOUSE sp|Q9CXW4|RL11_MOUSE sp|Q9EQH2|ERAP1_MOUSE sp|P30412|PPIC_MOUSE sp|Q7M6Y3|PICAL_MOUSE tr|E9PUM4|E9PUM4_MOUSE sp|Q9CQC6|BZW1_MOUSE tr|E9QNL5|E9QNL5_MOUSE sp|Q64523|H2A2C_MOUSE sp|O88738|BIRC6_MOUSE sp|P14576|SRP54_MOUSE sp|P50136|ODBA_MOUSE sp|P14901|HMOX1_MOUSE sp|Q9DBL9|ABHD5_MOUSE sp|P23780|BGAL_MOUSE sp|P56391|CX6B1_MOUSE sp|P97927|LAMA4_MOUSE sp|Q9CQ19|MYL9_MOUSE sp|O08601|MTP_MOUSE tr|Q91V89|Q91V89_MOUSE sp|P60335|PCBP1_MOUSE sp|Q9DBC7|KAP0_MOUSE sp|Q9D172|ES1_MOUSE sp|P31938|MP2K1_MOUSE
845.64 551.405 720.792 760.86 612.532 859.993 795.955 729.698 910.139 715.878 819.919 586.328 486.522 574.775 504.469 753.391 1077.17 1112.19 777.11 548.192 700.136 896.639 704.298 490.789 536.774 654.8 830.424 1100.87 424.73 712.275 588.406 519.373 218.442 378.067 850.704 653.807 544.917 925.371 784.285 672.71 946.803 754.907 533.717 900.969 780.857 764.518 820.287 618.423 562.155 537.408 400.733 608.206 1161.62 463.768 775.406 772.311 928.818 868.916 540.327 1510.29 748.081 721.689
513.769 276.108 772.156 776.61 1197.09 1159.85 1100.56 1077.63 872.044 836.834 809.158 560.669 1138.85 874.418 510.901 994.87 1479.16 1258.75 823.698 487.502 590.985 1481.9 636.18 548.251 800.371 657.491 516.615 1274.52 1329.41 879.479 961.248 381.14 1151.74 1650.04 551.824 316.767 439.865 936.449 652.758 807.517 270.647 340.006 427.994 761.955 797.081 219.288 1016.91 816.474 950.562 711.745 1335.08 419.434 767.422 638.181 510.709 732.632 985.107 790.72 595.036 1166.11 1235.71 846.201
1017.36 376.332 740.144 1275.22 1154.3 2402.69 1066.79 1165.09 1558.22 1243.94 1825.15 951.119 666.066 1895.8 1444.82 1403.74 1869.88 2321.2 1545.34 976.869 1051.22 1955.37 3004.49 1280.6 681.229 1733.98 1370.52 1575.35 1443.98 1099.78 1773.47 620.912 1081.85 3101.11 1215.52 638.868 411.771 529.98 1301.68 701.007 432.609 570.228 483.778 791.406 899.706 432.475 1497.46 1188.58 693.483 1365.3 2714.14 496.143 533.207 1181.21 398.519 1521.15 685.767 684.519 932.713 1891.25 3573.94 777.296
0.99 0.98 0.97 0.97 0.97 0.97 0.97 0.96 0.95 0.95 0.95 0.95 0.94 0.93 0.92 0.92 0.92 0.92 0.90 0.90 0.90 0.90 0.90 0.90 0.89 0.88 0.87 0.86 0.86 0.85 0.84 0.82 0.81 0.80 0.72 2.13 1.63 1.62 1.51 1.32 1.30 1.28 1.26 1.25 1.25 1.24 1.24 1.23 1.20 1.20 1.19 1.17 1.17 1.17 1.16 1.16 1.14 1.14 1.12 1.12 1.11 1.11
0.91 0.48 1.02 1.22 1.73 2.08 1.14 1.39 1.23 1.18 1.38 1.11 1.41 1.99 1.61 1.46 1.31 1.52 1.29 1.14 0.91 1.72 1.90 1.53 1.16 1.43 0.91 1.13 2.73 1.16 1.74 0.70 4.03 4.37 0.77 1.56 1.09 1.14 1.91 1.47 0.50 0.73 1.03 0.93 1.41 0.47 2.32 1.80 1.48 2.54 6.64 0.90 0.63 2.02 0.60 1.56 0.88 0.89 1.57 1.35 3.30 1.07
ACCEPTED MANUSCRIPT
584.279 641.52 584.594 520.841 599.106 930.656 693.289 681.321 735.368 485.627 1248.94 1075.51 705.401 673.172 863.177 460.355 846.104 783.466 537.07 554.927 825.526 655.438 621.594 981.642 670.603 508.821 595.318 738.31 1003.41 942.488 1083.13 1158.93 728.361 853.654 720.068 887.687 673.302 814.784 758.358 972.138 381.553 278.343 432.253 561.395 1430.89 657.932 476.959 534.496 428.364 709.297 647.834 571.657 565.918 504.717 481.591 750.287 648.406 840.486 556.235 479.677 444.882 665.276
675.401 816.59 642.518 599.474 756.731 852.751 784.118 837.037 770.309 615.075 849.998 1069.93 738.623 743.55 864.472 475.55 1049.02 840.739 504.25 633.282 816.592 531.14 589.386 991.191 733.718 474.311 692.721 713.774 1153.8 928.279 1057.54 701.415 708.497 958.344 566.28 768.636 612.141 477.741 786.187 816.497 663.81 535.491 743.042 1085.56 1414.42 813.552 803.602 748.021 606.865 1046.47 830.94 779.328 789.189 732.194 530.952 1037.09 957.079 1100.71 768.309 638.004 610.838 833.348
RI PT
595.682 743.103 589.399 528.753 683.525 762.973 780.462 710.537 744.711 621.053 877.856 918.311 737.989 691.57 746.834 456.639 918.955 924.561 505.818 566.849 777.785 672.032 614.616 972.376 723.83 521.584 693.117 723.754 1221.86 1007.18 1036.93 533.554 879.206 1071.33 789.625 833.526 691.743 799.765 993.973 870.245 397.142 330.458 435.892 637.056 1228.03 607.241 578.674 671.209 462.56 819.064 693.304 589.168 570.668 582.095 443.227 945.307 785.567 801.895 648.601 563.214 506.022 626.499
SC
14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
M AN U
TE D
SSRA_MOUSE Translocon-associated protein subunit alpha RM01_MOUSE 39S ribosomal protein L1, mitochondrial CAN2_MOUSE Calpain-2 catalytic subunit DPYL2_MOUSE Dihydropyrimidinase-related protein 2 TMED9_MOUSE Transmembrane emp24 domain-containing protein 9 UBE2N_MOUSE Ubiquitin-conjugating enzyme E2 N CSN1_MOUSE COP9 signalosome complex subunit 1 PROSC_MOUSE Proline synthase co-transcribed bacterial homolog protein PCY2_MOUSE Ethanolamine-phosphate cytidylyltransferase TWF1_MOUSE Twinfilin-1 RL29_MOUSE 60S ribosomal protein L29 DBNL_MOUSE Drebrin-like protein PYRG2_MOUSE CTP synthase 2 BAF_MOUSE Barrier-to-autointegration factor PRC2A_MOUSE Protein PRRC2A HGS_MOUSE Hepatocyte growth factor-regulated tyrosine kinase substrate PSME3_MOUSE Proteasome activator complex subunit 3 UBP7_MOUSE Ubiquitin carboxyl-terminal hydrolase 7 PABP2_MOUSE Polyadenylate-binding protein 2 F1142_MOUSE Isoform 2 of Protein FAM114A2 CATL1_MOUSE Cathepsin L1 AP3D1_MOUSE AP-3 complex subunit delta-1 DDAH1_MOUSE N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 DNJC8_MOUSE DnaJ homolog subfamily C member 8 COQ9_MOUSE Ubiquinone biosynthesis protein COQ9, mitochondrial RS14_MOUSE 40S ribosomal protein S14 IMPA1_MOUSE Inositol monophosphatase 1 PLIN3_MOUSE Perilipin-3 SNX6_MOUSE Sorting nexin-6 MARE1_MOUSE Microtubule-associated protein RP/EB family member 1 EWS_MOUSE RNA-binding protein EWS H14_MOUSE Histone H1.4 CSN5_MOUSE COP9 signalosome complex subunit 5 PLCB3_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 RL30_MOUSE 60S ribosomal protein L30 SH3K1_MOUSE SH3 domain-containing kinase-binding protein 1 HEM2_MOUSE Delta-aminolevulinic acid dehydratase ARF3_MOUSE ADP-ribosylation factor 3 SYHM_MOUSE Probable histidine--tRNA ligase, mitochondrial OS9_MOUSE Protein OS-9 TFR1_MOUSE Transferrin receptor protein 1 MGST1_MOUSE Microsomal glutathione S-transferase 1 CNN3_MOUSE Calponin-3 LRC59_MOUSE Leucine-rich repeat-containing protein 59 ATP5J_MOUSE ATP synthase-coupling factor 6, mitochondrial RS11_MOUSE 40S ribosomal protein S11 EMC3_MOUSE ER membrane protein complex subunit 3 AMPB_MOUSE Aminopeptidase B RL10_MOUSE 60S ribosomal protein L10 TM9S3_MOUSE Transmembrane 9 superfamily member 3 RRAS_MOUSE Ras-related protein R-Ras Q6A099_MOUSE MKIAA0248 protein (Fragment) PSB1_MOUSE Proteasome subunit beta type-1 NCOAT_MOUSE Bifunctional protein NCOAT SGPL1_MOUSE Sphingosine-1-phosphate lyase 1 RM15_MOUSE 39S ribosomal protein L15, mitochondrial ECHD1_MOUSE Ethylmalonyl-CoA decarboxylase TIM8A_MOUSE Mitochondrial import inner membrane translocase subunit Tim8 A PSMD6_MOUSE 26S proteasome non-ATPase regulatory subunit 6 RL9_MOUSE 60S ribosomal protein L9 ULA1_MOUSE NEDD8-activating enzyme E1 regulatory subunit S10AB_MOUSE Protein S100-A11
EP
Ssr1 Mrpl1 Capn2 Dpysl2 Tmed9 Ube2n Gps1 Prosc Pcyt2 Twf1 Rpl29 Dbnl Ctps2 Banf1 Prrc2a Hgs Psme3 Usp7 Pabpn1 Fam114a2 Ctsl Ap3d1 Ddah1 Dnajc8 Coq9 Rps14 Impa1 Plin3 Snx6 Mapre1 Ewsr1 Hist1h1e Cops5 Plcb3 Rpl30 Sh3kbp1 Alad Arf3 Hars2 Os9 Tfrc Mgst1 Cnn3 Lrrc59 Atp5j Rps11 Emc3 Rnpep Rpl10 Tm9sf3 Rras Gbf1 Psmb1 Mgea5 Sgpl1 Mrpl15 Echdc1 Timm8a1 Psmd6 Rpl9 Nae1 S100a11
AC C
sp|Q9CY50|SSRA_MOUSE sp|Q99N96|RM01_MOUSE sp|O08529|CAN2_MOUSE sp|O08553|DPYL2_MOUSE sp|Q99KF1|TMED9_MOUSE sp|P61089|UBE2N_MOUSE sp|Q99LD4|CSN1_MOUSE sp|Q9Z2Y8|PROSC_MOUSE sp|Q922E4|PCY2_MOUSE sp|Q91YR1|TWF1_MOUSE sp|P47915|RL29_MOUSE sp|Q62418|DBNL_MOUSE sp|P70303|PYRG2_MOUSE sp|O54962|BAF_MOUSE sp|Q7TSC1|PRC2A_MOUSE sp|Q99LI8|HGS_MOUSE sp|P61290|PSME3_MOUSE sp|Q6A4J8|UBP7_MOUSE sp|Q8CCS6|PABP2_MOUSE sp|Q8VE88-2|F1142_MOUSE sp|P06797|CATL1_MOUSE sp|O54774|AP3D1_MOUSE sp|Q9CWS0|DDAH1_MOUSE sp|Q6NZB0|DNJC8_MOUSE sp|Q8K1Z0|COQ9_MOUSE sp|P62264|RS14_MOUSE sp|O55023|IMPA1_MOUSE sp|Q9DBG5|PLIN3_MOUSE sp|Q6P8X1|SNX6_MOUSE sp|Q61166|MARE1_MOUSE sp|Q61545|EWS_MOUSE sp|P43274|H14_MOUSE sp|O35864|CSN5_MOUSE sp|P51432|PLCB3_MOUSE sp|P62889|RL30_MOUSE sp|Q8R550|SH3K1_MOUSE sp|P10518|HEM2_MOUSE sp|P61205|ARF3_MOUSE sp|Q99KK9|SYHM_MOUSE sp|Q8K2C7|OS9_MOUSE sp|Q62351|TFR1_MOUSE sp|Q91VS7|MGST1_MOUSE sp|Q9DAW9|CNN3_MOUSE sp|Q922Q8|LRC59_MOUSE sp|P97450|ATP5J_MOUSE sp|P62281|RS11_MOUSE sp|Q99KI3|EMC3_MOUSE sp|Q8VCT3|AMPB_MOUSE sp|Q6ZWV3|RL10_MOUSE sp|Q9ET30|TM9S3_MOUSE sp|P10833|RRAS_MOUSE tr|Q6A099|Q6A099_MOUSE sp|O09061|PSB1_MOUSE sp|Q9EQQ9|NCOAT_MOUSE sp|Q8R0X7|SGPL1_MOUSE sp|Q9CPR5|RM15_MOUSE sp|Q9D9V3|ECHD1_MOUSE sp|Q9WVA2|TIM8A_MOUSE sp|Q99JI4|PSMD6_MOUSE sp|P51410|RL9_MOUSE sp|Q8VBW6|ULA1_MOUSE sp|P50543|S10AB_MOUSE
629.158 710.168 650.963 546.104 631.017 959.581 790.105 641.529 776.545 537.15 1344.2 971.052 738.772 648.494 761.06 440.088 713.18 848.479 511.653 445.592 720.978 739.196 581.552 850.397 570.272 480.987 496.769 631.886 884.165 828.773 825.918 791.825 705.759 733.164 757.577 707.191 547.78 871.272 670.762 677.007 752.067 427.664 620.599 607.987 2118.4 847.13 576.85 754.37 502.356 845.715 794.895 626.885 582.162 578.933 580.551 984.281 742.924 838.472 634.936 564.47 469.816 605.175
737.373 561.898 915.112 513.312 621.046 1149.64 826.558 423.171 504.913 460.509 645.01 929.388 1324.77 662.343 526.751 490.012 861.361 718.65 384.786 731.799 438.168 547.957 719.416 832.018 340.417 1192.42 709.855 637.223 1076.35 578.452 977.981 1525.33 737.438 804.421 1163.25 752.446 414.559 766.958 468.951 484.163 103.548 1036.44 840.423 1227.26 531.727 656.771 633.899 582.832 1873.91 869.008 921.338 583.103 719.409 871.574 714.307 472.321 340.817 522.468 700.11 931.18 724.095 401.794
672.96 833.221 763.981 511.965 411.623 1936.44 700.133 701.908 596.556 450.425 1845.05 1417.45 1498.31 895.38 1085.63 551.622 1224.76 670.876 818.52 678.267 1087.47 638.222 1584.23 1548.45 676.98 1799.21 839.133 1229.53 1160.78 925.669 2146.99 1457.22 649.021 887.143 927.648 1601.89 429.318 767.54 629.266 1213.54 242.194 1131.83 1551.1 1427.43 2467.47 543.798 491.798 634.083 1523.52 538.615 448.651 516.255 523.171 803.299 482.825 724.196 462.9 1367.2 557.055 698.669 544.536 896.942
1.11 1.10 1.10 1.09 1.08 1.07 1.07 1.06 1.05 1.04 1.03 1.02 1.02 1.02 1.01 1.00 1.00 0.99 0.97 0.96 0.96 0.96 0.95 0.94 0.94 0.93 0.92 0.92 0.92 0.90 0.89 0.88 0.88 0.88 0.88 0.86 0.85 0.84 0.83 0.81 1.82 1.58 1.57 1.41 1.33 1.31 1.31 1.25 1.25 1.24 1.21 1.21 1.21 1.21 1.20 1.19 1.19 1.18 1.16 1.15 1.14 1.11
1.20 1.01 1.43 0.98 0.81 1.82 1.04 0.81 0.74 0.82 1.17 1.18 1.96 1.14 1.00 1.14 1.18 0.81 1.15 1.26 0.95 0.89 1.86 1.22 0.73 2.90 1.20 1.28 1.01 0.77 1.47 1.76 0.86 0.88 1.38 1.37 0.62 0.95 0.63 0.92 0.44 3.56 2.75 2.22 1.13 0.95 1.07 1.01 3.81 0.92 1.02 0.95 1.09 1.54 1.29 0.71 0.56 1.15 1.04 1.56 1.33 1.01
ACCEPTED MANUSCRIPT
TE D
398.108 672.92 441.657 715.023 680.154 516.508 668.878 808.048 675.596 621.643 528.451 613.353 620.873 477.568 630.801 481.056 545.472 478.352 544.244 810.655 673.063 454.966 723.764 438.155 634.973 674.302 550.664 708.447 881.577 1140.71 829.641 554.637 767.52 506.569 495.851 724.455 709.803 435.274 570.235 640.377 978.299 1128.3 817.25 696.717 820.81 1146.32 669.404 524.706 689.148 755.102 846.486 531.34 947.023 564.576 1001.58 723.357 531.082 468.777 371.096 705.81 789.941 612.395
459.7 870.179 481.073 661.171 833.052 533.138 727.073 745.764 890.045 587.014 664.759 692.23 688.864 510.203 795.541 515.738 582.462 532.909 707.638 895.454 739.012 584.051 798.625 512.527 704.973 891.195 690.792 731.795 1176.45 1091.86 820.097 625.322 784.377 502.312 553.288 767.887 644.109 457.248 544.907 656.48 966.949 1005.37 636.424 507.801 673.271 954.549 625.598 554.845 612.515 740.34 691.656 477.538 907.016 530.219 811.037 1035.96 1004.57 756.969 677.888 1070.98 1161.06 936.691
RI PT
377.624 784.043 432.834 618.568 769.057 482.511 688.537 619.852 844.467 555.366 638.077 635.507 596.315 483.614 746.445 454.128 602.788 560.919 734.28 825.388 722.028 541.393 735.162 474.575 657.528 927.41 676.542 713.047 1065.07 1236.15 706.968 584.391 752.14 475.426 566.509 804.987 571.494 484.938 498.82 598.475 882.93 918.173 564.981 708.104 676.269 894.113 642.052 547.171 569.461 910.342 770.015 453.062 1285.94 577.31 1015.78 654.979 623.948 350.105 415.77 638.322 749.154 745.474
SC
13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 12 12 12 12 12 12 12
M AN U
PGRC1_MOUSE Membrane-associated progesterone receptor component 1 CCAR2_MOUSE Cell cycle and apoptosis regulator protein 2 TBCD4_MOUSE TBC1 domain family member 4 HMGN5_MOUSE High mobility group nucleosome-binding domain-containing protein 5 S23IP_MOUSE SEC23-interacting protein ACPM_MOUSE Acyl carrier protein, mitochondrial CMC1_MOUSE Calcium-binding mitochondrial carrier protein Aralar1 DLRB1_MOUSE Dynein light chain roadblock-type 1 RMD1_MOUSE Regulator of microtubule dynamics protein 1 METK2_MOUSE S-adenosylmethionine synthase isoform type-2 LIS1_MOUSE Platelet-activating factor acetylhydrolase IB subunit alpha ARL3_MOUSE ADP-ribosylation factor-like protein 3 FUBP1_MOUSE Far upstream element-binding protein 1 SRRT_MOUSE Serrate RNA effector molecule homolog DYN2_MOUSE Dynamin-2 IF1AX_MOUSE Eukaryotic translation initiation factor 1A, X-chromosomal RAB5C_MOUSE Ras-related protein Rab-5C VA0D1_MOUSE V-type proton ATPase subunit d 1 HNRL1_MOUSE Heterogeneous nuclear ribonucleoprotein U-like protein 1 PTGR2_MOUSE Prostaglandin reductase 2 DHX15_MOUSE Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 SCPDL_MOUSE Saccharopine dehydrogenase-like oxidoreductase PCY1A_MOUSE Choline-phosphate cytidylyltransferase A NPL4_MOUSE Nuclear protein localization protein 4 homolog SNW1_MOUSE SNW domain-containing protein 1 PCCB_MOUSE Propionyl-CoA carboxylase beta chain, mitochondrial HS74L_MOUSE Heat shock 70 kDa protein 4L CYBP_MOUSE Calcyclin-binding protein CISD1_MOUSE CDGSH iron-sulfur domain-containing protein 1 RL21_MOUSE 60S ribosomal protein L21 NDUV2_MOUSE NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial IGBP1_MOUSE Immunoglobulin-binding protein 1 RU17_MOUSE U1 small nuclear ribonucleoprotein 70 kDa FKB1A_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP1A FNTA_MOUSE Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha XPP1_MOUSE Xaa-Pro aminopeptidase 1 AIP_MOUSE AH receptor-interacting protein RCC2_MOUSE Protein RCC2 HEBP1_MOUSE Heme-binding protein 1 CRKL_MOUSE Crk-like protein CFDP1_MOUSE Craniofacial development protein 1 UBE2H_MOUSE Ubiquitin-conjugating enzyme E2 H NUFP2_MOUSE Nuclear fragile X mental retardation-interacting protein 2 RS15A_MOUSE 40S ribosomal protein S15a Q3U741_MOUSE DEAD (Asp-Glu-Ala-Asp) box polypeptide 17, isoform CRA_a SKP1_MOUSE S-phase kinase-associated protein 1 B1AZ46_MOUSE Brain-specific angiogenesis inhibitor 1-associated protein 2 D3YWX2_MOUSE YLP motif-containing protein 1 SDHF2_MOUSE Succinate dehydrogenase assembly factor 2, mitochondrial PTPA_MOUSE Serine/threonine-protein phosphatase 2A activator HINT1_MOUSE Histidine triad nucleotide-binding protein 1 IF4H_MOUSE Eukaryotic translation initiation factor 4H ANM1_MOUSE Protein arginine N-methyltransferase 1 PCKGM_MOUSE Phosphoenolpyruvate carboxykinase [GTP], mitochondrial DHRS4_MOUSE Dehydrogenase/reductase SDR family member 4 F8VPN4_MOUSE Protein Agl ACSA_MOUSE Acetyl-coenzyme A synthetase, cytoplasmic AUHM_MOUSE Methylglutaconyl-CoA hydratase, mitochondrial LYRIC_MOUSE Protein LYRIC THTR_MOUSE Thiosulfate sulfurtransferase AGK_MOUSE Acylglycerol kinase, mitochondrial RT05_MOUSE 28S ribosomal protein S5, mitochondrial
EP
Pgrmc1 Ccar2 Tbc1d4 Hmgn5 Sec23ip Ndufab1 Slc25a12 Dynlrb1 Rmdn1 Mat2a Pafah1b1 Arl3 Fubp1 Srrt Dnm2 Eif1ax Rab5c Atp6v0d1 Hnrnpul1 Ptgr2 Dhx15 Sccpdh Pcyt1a Nploc4 Snw1 Pccb Hspa4l Cacybp Cisd1 Rpl21 Ndufv2 Igbp1 Snrnp70 Fkbp1a Fnta Xpnpep1 Aip Rcc2 Hebp1 Crkl Cfdp1 Ube2h Nufip2 Rps15a Ddx17 Skp1 Baiap2 Ylpm1 Sdhaf2 Ppp2r4 Hint1 Eif4h Prmt1 Pck2 Dhrs4 Agl Acss2 Auh Mtdh Tst Agk Mrps5
AC C
sp|O55022|PGRC1_MOUSE sp|Q8VDP4|CCAR2_MOUSE sp|Q8BYJ6|TBCD4_MOUSE sp|Q9JL35|HMGN5_MOUSE sp|Q6NZC7|S23IP_MOUSE sp|Q9CR21|ACPM_MOUSE sp|Q8BH59|CMC1_MOUSE sp|P62627|DLRB1_MOUSE sp|Q9DCV4|RMD1_MOUSE sp|Q3THS6|METK2_MOUSE sp|P63005|LIS1_MOUSE sp|Q9WUL7|ARL3_MOUSE sp|Q91WJ8|FUBP1_MOUSE sp|Q99MR6|SRRT_MOUSE sp|P39054|DYN2_MOUSE sp|Q8BMJ3|IF1AX_MOUSE sp|P35278|RAB5C_MOUSE sp|P51863|VA0D1_MOUSE sp|Q8VDM6|HNRL1_MOUSE sp|Q8VDQ1|PTGR2_MOUSE sp|O35286|DHX15_MOUSE sp|Q8R127|SCPDL_MOUSE sp|P49586|PCY1A_MOUSE sp|P60670|NPL4_MOUSE sp|Q9CSN1|SNW1_MOUSE sp|Q99MN9|PCCB_MOUSE sp|P48722|HS74L_MOUSE sp|Q9CXW3|CYBP_MOUSE sp|Q91WS0|CISD1_MOUSE sp|O09167|RL21_MOUSE sp|Q9D6J6|NDUV2_MOUSE sp|Q61249|IGBP1_MOUSE sp|Q62376|RU17_MOUSE sp|P26883|FKB1A_MOUSE sp|Q61239|FNTA_MOUSE sp|Q6P1B1|XPP1_MOUSE sp|O08915|AIP_MOUSE sp|Q8BK67|RCC2_MOUSE sp|Q9R257|HEBP1_MOUSE sp|P47941|CRKL_MOUSE sp|O88271|CFDP1_MOUSE sp|P62257|UBE2H_MOUSE sp|Q5F2E7|NUFP2_MOUSE sp|P62245|RS15A_MOUSE tr|Q3U741|Q3U741_MOUSE sp|Q9WTX5|SKP1_MOUSE tr|B1AZ46|B1AZ46_MOUSE tr|D3YWX2|D3YWX2_MOUSE sp|Q8C6I2|SDHF2_MOUSE sp|P58389|PTPA_MOUSE sp|P70349|HINT1_MOUSE sp|Q9WUK2|IF4H_MOUSE sp|Q9JIF0|ANM1_MOUSE sp|Q8BH04|PCKGM_MOUSE sp|Q99LB2|DHRS4_MOUSE tr|F8VPN4|F8VPN4_MOUSE sp|Q9QXG4|ACSA_MOUSE sp|Q9JLZ3|AUHM_MOUSE sp|Q80WJ7|LYRIC_MOUSE sp|P52196|THTR_MOUSE sp|Q9ESW4|AGK_MOUSE sp|Q99N87|RT05_MOUSE
396.396 736.668 472.344 784.437 714.326 525.752 708.754 761.906 704.144 644.826 542.616 595.05 565.485 476.774 616.39 433.86 580.185 518.963 585.536 756.975 669.739 421.547 666.653 400.255 585.757 701.811 529.025 675.673 742.662 1248.34 691.514 491.671 702.125 454.346 471.17 700.015 583.772 421.962 464.004 510.963 785.353 914.069 647.048 783.695 700.528 906.775 559.705 393.014 474.984 681.689 682.622 352.2 952.402 394.01 700.634 1350.94 877.306 519.709 500.329 787.982 907.599 812.622
730.67 1027.76 662.855 587.997 807.092 727.259 979.984 619.622 587.394 480.808 712.808 756.175 733.398 462.906 1329.66 479.613 627.192 917.453 473.602 611.266 922.613 872.677 482.129 556.435 405.698 506.525 783.913 702.832 980.313 849.978 533.269 360.802 656.794 479.316 589.06 674.766 536.283 722.555 654.482 437.41 549.61 864.148 497.632 776.763 1034.49 828.795 596.102 255.462 576.209 628.095 554.35 509.16 767.757 821.395 622.134 266.538 362.379 569.324 334.555 376.533 978.474 355.25
852.174 1111.11 596.257 1333.99 876.174 2309.02 610.204 1389.59 1032.16 722.582 639.274 1271.6 1349.24 711.427 954.905 827.609 539.139 927.741 440.166 1162.31 1044.22 652.601 990.728 675.846 876.798 848.836 586.637 899.809 805.112 1179 1153.48 701.034 1463.08 817.706 485.684 515.903 1100.31 500.044 1049.79 842.941 1155.93 1638.77 906.715 706.47 1360.91 1949.5 809.103 515.886 1338.26 543.657 1087.58 1236.14 757.274 2157.55 779.112 266.952 345.991 716.122 715.7 712.783 966.869 708.325
1.10 1.10 1.09 1.08 1.07 1.06 1.06 1.06 1.05 1.05 1.04 1.03 1.03 1.03 1.03 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.97 0.96 0.96 0.96 0.96 0.94 0.94 0.94 0.94 0.93 0.92 0.92 0.91 0.90 0.88 0.86 0.85 0.85 0.84 0.83 0.81 0.75 1.73 1.63 1.56 1.50 1.38 1.34 1.29
2.04 1.47 1.44 1.44 1.16 3.04 1.17 1.41 1.07 1.02 1.16 1.62 1.71 1.22 1.66 1.40 1.02 1.78 0.71 1.08 1.41 1.53 1.01 1.35 0.99 0.85 1.12 1.13 0.92 0.85 1.10 0.93 1.39 1.32 1.01 0.78 1.28 1.33 1.59 1.03 0.92 1.22 1.02 1.06 1.60 1.36 1.07 0.72 1.52 0.70 1.02 1.77 0.68 2.61 0.69 0.39 0.61 1.57 1.33 0.81 1.26 0.78
ACCEPTED MANUSCRIPT
TE D
487.575 464.11 1055.12 843.798 548.692 626.501 519.945 556.476 425.87 518.788 440.418 877.637 671.892 507.251 475.906 538.842 592.797 465.239 503.967 313.586 730.429 542.836 511.08 811.354 221.374 670.824 424.945 412.725 783.412 818 339.348 615.725 538.991 903.274 600.113 517.425 526.961 588.811 505.993 926.034 648.548 354.268 652.732 574.326 509.295 622.362 380.593 624.963 503.95 464.365 624.863 787.173 471.072 590.811 486.657 718.218 744.674 587.423 604.119 466.999 534.642 825.147
772.896 768.422 1569.55 1014.81 866.316 836.07 789.363 730.132 467.694 928.096 656.8 1269.07 951.242 639.416 602.753 640.353 625.381 616.266 683.604 417.263 959.164 601.396 569.787 821.216 1148.64 785.251 517.95 557.638 862.361 698.018 408.635 775.563 637.11 893.454 715.094 499.224 705.501 710.29 596.354 942.533 782.727 377.363 758.71 762.205 568.08 518.096 401.681 584.768 448.208 404.095 618.066 883.064 465.541 563.4 528.244 705.768 887.592 550.735 583.341 448.173 605.818 743.549
RI PT
559.395 578.73 1161.26 663.122 678.42 647.688 611.025 565.307 383.35 718.94 564.127 1060.32 899.22 539.624 507.963 536.923 519.976 498.959 572.814 356.395 896.158 522.327 475.839 688.827 1026.22 730.201 446.852 498.433 777.56 682.038 331.252 731.233 535.863 792.256 606.43 437.386 669.681 618.445 565.838 939.854 724.842 376.437 766.034 753.91 562.794 453.356 362.737 499.706 386.312 391.791 555.386 909.517 451.351 597.96 644.681 646.772 973.166 569.555 553.17 438.635 680.839 731.375
SC
12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12 12
M AN U
F8VQC7_MOUSE Kinectin ACTN1_MOUSE Alpha-actinin-1 RB11B_MOUSE Ras-related protein Rab-11B THIOM_MOUSE Thioredoxin, mitochondrial CSKP_MOUSE Peripheral plasma membrane protein CASK CYB5B_MOUSE Cytochrome b5 type B STIM1_MOUSE Stromal interaction molecule 1 HUWE1_MOUSE E3 ubiquitin-protein ligase HUWE1 NSUN2_MOUSE tRNA (cytosine(34)-C(5))-methyltransferase FAAA_MOUSE Fumarylacetoacetase ACAD9_MOUSE Acyl-CoA dehydrogenase family member 9, mitochondrial HA11_MOUSE H-2 class I histocompatibility antigen, D-B alpha chain RT27_MOUSE 28S ribosomal protein S27, mitochondrial RHG01_MOUSE Rho GTPase-activating protein 1 RHEB_MOUSE GTP-binding protein Rheb IF2G_MOUSE Eukaryotic translation initiation factor 2 subunit 3, X-linked VATH_MOUSE V-type proton ATPase subunit H SPRE_MOUSE Sepiapterin reductase ERLN2_MOUSE Erlin-2 DYL2_MOUSE Dynein light chain 2, cytoplasmic DCMC_MOUSE Malonyl-CoA decarboxylase, mitochondrial HCFC1_MOUSE Host cell factor 1 NUDC2_MOUSE NudC domain-containing protein 2 Q3TMX5_MOUSE Arginine-rich, mutated in early stage tumors, isoform CRA_b PDCD4_MOUSE Programmed cell death protein 4 RS25_MOUSE 40S ribosomal protein S25 MAP1A_MOUSE Microtubule-associated protein 1A B1AUN2_MOUSE MCG14442 MRP1_MOUSE Multidrug resistance-associated protein 1 HXK1_MOUSE Hexokinase-1 GRHPR_MOUSE Glyoxylate reductase/hydroxypyruvate reductase STAT3_MOUSE Signal transducer and activator of transcription 3 MTDC_MOUSE Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial IF1A_MOUSE Eukaryotic translation initiation factor 1A RSU1_MOUSE Ras suppressor protein 1 CDV3_MOUSE Protein CDV3 E9Q828_MOUSE Protein Atp2b4 CC90B_MOUSE Coiled-coil domain-containing protein 90B, mitochondrial LARP1_MOUSE La-related protein 1 MGN_MOUSE Protein mago nashi homolog QCR1_MOUSE Cytochrome b-c1 complex subunit 1, mitochondrial SC23A_MOUSE Protein transport protein Sec23A CSAD_MOUSE Cysteine sulfinic acid decarboxylase NDUV1_MOUSE NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial P3H1_MOUSE Prolyl 3-hydroxylase 1 EIF1_MOUSE Eukaryotic translation initiation factor 1 NASP_MOUSE Nuclear autoantigenic sperm protein OSTF1_MOUSE Osteoclast-stimulating factor 1 TEBP_MOUSE Prostaglandin E synthase 3 SUGT1_MOUSE Suppressor of G2 allele of SKP1 homolog SHLB1_MOUSE Endophilin-B1 NRDC_MOUSE Nardilysin Q99J77_MOUSE N-acetylneuraminic acid synthase (Sialic acid synthase) 1433F_MOUSE 14-3-3 protein eta RBM25_MOUSE RNA-binding protein 25 GORS2_MOUSE Golgi reassembly-stacking protein 2 ASNA_MOUSE ATPase Asna1 RBM8A_MOUSE RNA-binding protein 8A G3BP1_MOUSE Ras GTPase-activating protein-binding protein 1 GRSF1_MOUSE G-rich sequence factor 1 FAF1_MOUSE FAS-associated factor 1 TXLNA_MOUSE Alpha-taxilin
EP
Ktn1 Actn1 Rab11b Txn2 Cask Cyb5b Stim1 Huwe1 Nsun2 Fah Acad9 H2-D1 Mrps27 Arhgap1 Rheb Eif2s3x Atp6v1h Spr Erlin2 Dynll2 Mlycd Hcfc1 Nudcd2 Manf Pdcd4 Rps25 Map1a Eif2b3 Abcc1 Hk1 Grhpr Stat3 Mthfd2 Eif1a Rsu1 Cdv3 Atp2b4 Ccdc90b Larp1 Magoh Uqcrc1 Sec23a Csad Ndufv1 Lepre1 Eif1 Nasp Ostf1 Ptges3 Sugt1 Sh3glb1 Nrd1 Nans Ywhah Rbm25 Gorasp2 Asna1 Rbm8a G3bp1 Grsf1 Faf1 Txlna
AC C
tr|F8VQC7|F8VQC7_MOUSE sp|Q7TPR4|ACTN1_MOUSE sp|P46638|RB11B_MOUSE sp|P97493|THIOM_MOUSE sp|O70589|CSKP_MOUSE sp|Q9CQX2|CYB5B_MOUSE sp|P70302|STIM1_MOUSE sp|Q7TMY8|HUWE1_MOUSE sp|Q1HFZ0|NSUN2_MOUSE sp|P35505|FAAA_MOUSE sp|Q8JZN5|ACAD9_MOUSE sp|P01899|HA11_MOUSE sp|Q8BK72|RT27_MOUSE sp|Q5FWK3|RHG01_MOUSE sp|Q921J2|RHEB_MOUSE sp|Q9Z0N1|IF2G_MOUSE sp|Q8BVE3|VATH_MOUSE sp|Q64105|SPRE_MOUSE sp|Q8BFZ9|ERLN2_MOUSE sp|Q9D0M5|DYL2_MOUSE sp|Q99J39|DCMC_MOUSE sp|Q61191|HCFC1_MOUSE sp|Q9CQ48|NUDC2_MOUSE tr|Q3TMX5|Q3TMX5_MOUSE sp|Q61823|PDCD4_MOUSE sp|P62852|RS25_MOUSE sp|Q9QYR6|MAP1A_MOUSE tr|B1AUN2|B1AUN2_MOUSE sp|O35379|MRP1_MOUSE sp|P17710|HXK1_MOUSE sp|Q91Z53|GRHPR_MOUSE sp|P42227|STAT3_MOUSE sp|P18155|MTDC_MOUSE sp|Q60872|IF1A_MOUSE sp|Q01730|RSU1_MOUSE sp|Q4VAA2|CDV3_MOUSE tr|E9Q828|E9Q828_MOUSE sp|Q8C3X2|CC90B_MOUSE sp|Q6ZQ58|LARP1_MOUSE sp|P61327|MGN_MOUSE sp|Q9CZ13|QCR1_MOUSE sp|Q01405|SC23A_MOUSE sp|Q9DBE0|CSAD_MOUSE sp|Q91YT0|NDUV1_MOUSE sp|Q3V1T4|P3H1_MOUSE sp|P48024|EIF1_MOUSE sp|Q99MD9|NASP_MOUSE sp|Q62422|OSTF1_MOUSE sp|Q9R0Q7|TEBP_MOUSE sp|Q9CX34|SUGT1_MOUSE sp|Q9JK48|SHLB1_MOUSE sp|Q8BHG1|NRDC_MOUSE tr|Q99J77|Q99J77_MOUSE sp|P68510|1433F_MOUSE sp|B2RY56|RBM25_MOUSE sp|Q99JX3|GORS2_MOUSE sp|O54984|ASNA_MOUSE sp|Q9CWZ3|RBM8A_MOUSE sp|P97855|G3BP1_MOUSE sp|Q8C5Q4|GRSF1_MOUSE sp|P54731|FAF1_MOUSE sp|Q6PAM1|TXLNA_MOUSE
568.644 530.783 1177.23 828.365 629.59 716.392 586.887 634.367 511.631 558.461 548.984 1019.83 880.849 568.481 531.129 599.222 655.384 482.93 543.633 338.163 868.853 589.662 527.469 844.135 233.939 755.175 436.752 427.606 820.994 901.735 304.046 651.015 499.025 895.161 552.719 499.27 523.775 522.186 494.704 949.709 608.099 362.069 666.205 571.148 501.623 551.779 329.47 513.407 414.584 418.675 515.379 728.127 409.858 552.817 532.32 567.881 713.352 522.257 488.331 381.069 506.014 672.568
649.486 1217.19 1105.72 728.965 725.892 473.575 478.185 920.306 854.942 390.839 546.252 845.965 389.716 602.407 657.275 921.497 610.858 993.499 903.407 824.417 651.821 504.943 533.079 607.99 206.856 582.708 340.411 511.029 1005.99 2227.85 444.105 719.775 684.847 672.367 462.639 277.504 385.743 542.846 688.147 1033.55 562.505 402.003 610.24 706.667 402.524 420.01 978.897 888.387 1138.48 536.734 415.468 536.931 494.866 640.035 723.122 541.194 1273.66 337.19 495.928 314.752 529.832 504.128
1229.87 676.875 967.59 2290.55 651.896 849.369 1021.48 752.163 1123.03 343.714 521.285 1111.54 486.237 580.315 601.945 582.286 444.144 1214.2 1000.52 913.593 780.578 691.106 1031.47 1174.61 399.232 1459.72 358.605 527.638 844.013 628.294 501.98 529.314 1355.57 1165.02 572.825 430.163 349.857 679.153 697.603 1189.97 779.128 319.17 806.196 630.001 309.249 1468.16 767.236 1448.36 2630.8 795.192 804.094 613.039 670.71 603.834 940.817 1121.73 1074.07 702.151 1083.04 950.707 638.383 1223.32
1.28 1.25 1.24 1.22 1.22 1.22 1.22 1.22 1.21 1.20 1.20 1.18 1.17 1.15 1.15 1.15 1.15 1.14 1.14 1.13 1.12 1.12 1.11 1.11 1.11 1.10 1.10 1.08 1.08 1.07 1.06 1.06 1.06 1.05 1.05 1.05 1.03 1.02 1.02 1.01 1.01 1.01 1.00 1.00 1.00 0.99 0.98 0.98 0.97 0.96 0.96 0.95 0.95 0.94 0.94 0.93 0.93 0.93 0.93 0.92 0.91 0.91
1.80 1.82 0.94 2.00 1.12 1.04 1.33 1.49 2.44 0.59 1.06 1.01 0.56 1.13 1.28 1.40 0.95 2.29 1.77 2.59 0.88 1.12 1.59 1.19 0.49 1.46 0.80 1.14 1.19 1.90 1.41 0.93 1.90 1.08 0.86 0.74 0.61 1.01 1.29 1.19 0.98 0.99 1.00 1.01 0.66 1.76 2.35 2.08 4.23 1.56 1.03 0.68 1.26 1.05 1.47 1.22 1.37 0.90 1.36 1.40 0.96 1.11
ACCEPTED MANUSCRIPT
TE D
532.715 493.301 628.041 393.515 566.373 853.534 470.467 570.445 424.104 714.986 825.34 507.972 854.003 408.601 455.138 698.995 311.823 306.937 406.273 497.527 525.481 402.799 648.672 409.65 521.349 678.29 1196.99 485.893 678.014 342.081 751.205 664.13 584.779 332.443 374.569 584.26 265.962 436.123 555.595 546.823 559.089 506.039 654.249 854.822 544.058 439.541 364.226 557.082 639.203 546.693 479.788 428.413 564.814 472.932 437.979 638.396 1067.63 457.861 847.319 627.854 499.964 488.304
633.689 501.464 514.581 422.701 617.828 663.18 414.256 647.224 306.821 634.073 728.212 504.691 563.293 843.14 859.484 931.836 526.972 491.834 685.382 830.567 811.597 539.04 911.16 752.155 735.323 622.79 1184.51 778.597 954.688 544.414 658.743 1111.4 944.281 465.979 549.739 912.508 427.878 629.992 728.357 721.715 725.49 694.502 916.711 859.628 739.163 505.14 324.134 716.68 928.151 626.101 436.268 603.358 654.872 607.922 483.784 851.56 763.317 524.814 937.515 719.095 650.099 614.645
RI PT
712.234 511.552 633.278 487.721 692.529 683.948 560.257 743.448 398.424 667.676 777.143 637.675 642.1 435.149 404.284 403.37 318.674 316.948 461.968 684.394 557.261 345.641 597.426 458.417 516.163 429.439 1043.55 553.229 774.725 414.486 639.906 727.493 687.867 390.117 428.557 690.293 319.458 524.172 599.335 621.193 542.081 551.352 734.326 752.399 603.994 430.544 334.902 637.748 771.716 583.366 490.147 532.323 626.29 501.782 415.091 748.028 889.26 439.511 818.646 550.437 583.583 565.299
SC
12 12 12 12 12 12 12 12 12 12 12 12 12 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
M AN U
PNPT1_MOUSE Polyribonucleotide nucleotidyltransferase 1, mitochondrial GEPH_MOUSE Gephyrin EIF3M_MOUSE Eukaryotic translation initiation factor 3 subunit M ENTP5_MOUSE Ectonucleoside triphosphate diphosphohydrolase 5 SNX5_MOUSE Sorting nexin-5 RL35_MOUSE 60S ribosomal protein L35 CAZA2_MOUSE F-actin-capping protein subunit alpha-2 PLCB1_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 IPO7_MOUSE Importin-7 LZIC_MOUSE Protein LZIC GRN_MOUSE Granulins IMDH1_MOUSE Inosine-5'-monophosphate dehydrogenase 1 ANXA2_MOUSE Annexin A2 HYEP_MOUSE Epoxide hydrolase 1 COX6C_MOUSE Cytochrome c oxidase subunit 6C NDUA4_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 PLXB2_MOUSE Plexin-B2 GUAD_MOUSE Guanine deaminase MYOF_MOUSE Myoferlin ADIPO_MOUSE Adiponectin ACOX1_MOUSE Peroxisomal acyl-coenzyme A oxidase 1 NHRF1_MOUSE Na(+)/H(+) exchange regulatory cofactor NHE-RF1 RN213_MOUSE E3 ubiquitin-protein ligase RNF213 TMTC3_MOUSE Transmembrane and TPR repeat-containing protein 3 F120A_MOUSE Constitutive coactivator of PPAR-gamma-like protein 1 IF4B_MOUSE Eukaryotic translation initiation factor 4B RL28_MOUSE 60S ribosomal protein L28 SRPK1_MOUSE SRSF protein kinase 1 TMEDA_MOUSE Transmembrane emp24 domain-containing protein 10 MFN2_MOUSE Mitofusin-2 CATB_MOUSE Cathepsin B CAB45_MOUSE 45 kDa calcium-binding protein SQRD_MOUSE Sulfide:quinone oxidoreductase, mitochondrial VPP1_MOUSE V-type proton ATPase 116 kDa subunit a isoform 1 SMC1A_MOUSE Structural maintenance of chromosomes protein 1A ASAH1_MOUSE Acid ceramidase STX4_MOUSE Syntaxin-4 PAPS1_MOUSE Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 DRG1_MOUSE Developmentally-regulated GTP-binding protein 1 AT131_MOUSE Probable cation-transporting ATPase 13A1 ARFG1_MOUSE ADP-ribosylation factor GTPase-activating protein 1 NUP93_MOUSE Nuclear pore complex protein Nup93 PRAF3_MOUSE PRA1 family protein 3 RETST_MOUSE All-trans-retinol 13,14-reductase THTM_MOUSE 3-mercaptopyruvate sulfurtransferase GFPT1_MOUSE Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 IPO9_MOUSE Importin-9 SCMC1_MOUSE Calcium-binding mitochondrial carrier protein SCaMC-1 TB10B_MOUSE TBC1 domain family member 10B ATLA2_MOUSE Atlastin-2 RL35A_MOUSE 60S ribosomal protein L35a PLCG1_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 RAB10_MOUSE Ras-related protein Rab-10 RT22_MOUSE 28S ribosomal protein S22, mitochondrial FRIH_MOUSE Ferritin heavy chain DCPS_MOUSE m7GpppX diphosphatase ACOD1_MOUSE Acyl-CoA desaturase 1 SNP23_MOUSE Synaptosomal-associated protein 23 UFD1_MOUSE Ubiquitin fusion degradation protein 1 homolog ZC3HF_MOUSE Zinc finger CCCH domain-containing protein 15 ARM10_MOUSE Armadillo repeat-containing protein 10 UBP15_MOUSE Ubiquitin carboxyl-terminal hydrolase 15
EP
Pnpt1 Gphn Eif3m Entpd5 Snx5 Rpl35 Capza2 Plcb1 Ipo7 Lzic Grn Impdh1 Anxa2 Ephx1 Cox6c Ndufa4 Plxnb2 Gda Myof Adipoq Acox1 Slc9a3r1 Rnf213 Tmtc3 FAM120A Eif4b Rpl28 Srpk1 Tmed10 Mfn2 Ctsb Sdf4 Sqrdl Atp6v0a1 Smc1a Asah1 Stx4 Papss1 Drg1 Atp13a1 Arfgap1 Nup93 Arl6ip5 Retsat Mpst Gfpt1 Ipo9 Slc25a24 Tbc1d10b Atl2 Rpl35a Plcg1 Rab10 Mrps22 Fth1 Dcps Scd1 Snap23 Ufd1l Zc3h15 Armc10 Usp15
AC C
sp|Q8K1R3|PNPT1_MOUSE sp|Q8BUV3|GEPH_MOUSE sp|Q99JX4|EIF3M_MOUSE sp|Q9WUZ9|ENTP5_MOUSE sp|Q9D8U8|SNX5_MOUSE sp|Q6ZWV7|RL35_MOUSE sp|P47754|CAZA2_MOUSE sp|Q9Z1B3|PLCB1_MOUSE sp|Q9EPL8|IPO7_MOUSE sp|Q8K3C3|LZIC_MOUSE sp|P28798|GRN_MOUSE sp|P50096|IMDH1_MOUSE sp|P07356|ANXA2_MOUSE sp|Q9D379|HYEP_MOUSE sp|Q9CPQ1|COX6C_MOUSE sp|Q62425|NDUA4_MOUSE sp|B2RXS4|PLXB2_MOUSE sp|Q9R111|GUAD_MOUSE sp|Q69ZN7|MYOF_MOUSE sp|Q60994|ADIPO_MOUSE sp|Q9R0H0|ACOX1_MOUSE sp|P70441|NHRF1_MOUSE sp|E9Q555|RN213_MOUSE sp|Q8BRH0|TMTC3_MOUSE sp|Q6A0A9|F120A_MOUSE sp|Q8BGD9|IF4B_MOUSE sp|P41105|RL28_MOUSE sp|O70551|SRPK1_MOUSE sp|Q9D1D4|TMEDA_MOUSE sp|Q80U63|MFN2_MOUSE sp|P10605|CATB_MOUSE sp|Q61112|CAB45_MOUSE sp|Q9R112|SQRD_MOUSE sp|Q9Z1G4|VPP1_MOUSE sp|Q9CU62|SMC1A_MOUSE sp|Q9WV54|ASAH1_MOUSE sp|P70452|STX4_MOUSE sp|Q60967|PAPS1_MOUSE sp|P32233|DRG1_MOUSE sp|Q9EPE9|AT131_MOUSE sp|Q9EPJ9|ARFG1_MOUSE sp|Q8BJ71|NUP93_MOUSE sp|Q8R5J9|PRAF3_MOUSE sp|Q64FW2|RETST_MOUSE sp|Q99J99|THTM_MOUSE sp|P47856|GFPT1_MOUSE sp|Q91YE6|IPO9_MOUSE sp|Q8BMD8|SCMC1_MOUSE sp|Q8BHL3|TB10B_MOUSE sp|Q6PA06|ATLA2_MOUSE sp|O55142|RL35A_MOUSE sp|Q62077|PLCG1_MOUSE sp|P61027|RAB10_MOUSE sp|Q9CXW2|RT22_MOUSE sp|P09528|FRIH_MOUSE sp|Q9DAR7|DCPS_MOUSE sp|P13516|ACOD1_MOUSE sp|O09044|SNP23_MOUSE sp|P70362|UFD1_MOUSE sp|Q3TIV5|ZC3HF_MOUSE sp|Q9D0L7|ARM10_MOUSE sp|Q8R5H1|UBP15_MOUSE
494.686 403.025 620.477 361.643 475.27 667.646 477.423 488.021 403.304 558.052 635.585 390.627 567.105 826.826 796.267 810.163 420.944 427.642 590.25 896.845 765.495 544.05 884.309 495.089 734.445 904.7 1828.18 606.34 951.294 446.529 1136.04 683.434 661.374 427.682 436.022 650.82 286.572 522.037 648.734 665.178 576.332 543.476 707.232 981.491 563.604 479.861 466.567 634.064 653.848 638.961 648.379 467.67 663.723 467.744 454.786 657.869 1358.48 443.504 850.192 543.509 510.628 512.036
432.457 510.815 923.771 712.755 479.962 588.42 1022.28 604.305 1356.19 725.659 466.461 675.673 1265.75 807.302 1064.26 460.521 576.611 457.728 704.873 100.326 895.079 306.224 981.647 655.719 608.47 548.937 943.325 838.362 720.059 229.372 358.439 193.973 278.556 412.601 366.374 389.972 551.562 499.728 652.415 601.697 334.815 746.107 661.718 369.833 272.136 906.343 353.274 954.095 594.326 648.51 485.257 509.585 658.301 373.467 939.417 664.03 311.314 364.993 752.361 506.155 607.865 406.441
527.887 786.708 605.448 964.536 498.479 915.64 1216.9 654.776 815.762 1436.75 937.87 996.707 424.991 722.367 488.748 935.081 376.274 526.551 429.409 204.915 389.927 617.252 805.395 338.204 591.981 822.841 1147.12 951.594 546.065 240.603 852.9 542.841 540.865 355.824 442.068 387.182 432.733 444.912 489.115 613.183 795.114 451.612 467.363 851.159 884.154 614.111 339.221 613.772 522.628 737.245 423.531 476.182 518.031 584.659 1288.95 620.456 1109.09 571.766 1176.27 924.212 533.032 558.91
0.91 0.90 0.90 0.89 0.87 0.87 0.87 0.86 0.86 0.86 0.85 0.78 0.76 1.98 1.93 1.58 1.50 1.47 1.47 1.46 1.46 1.45 1.44 1.44 1.42 1.38 1.34 1.33 1.31 1.31 1.29 1.29 1.26 1.24 1.23 1.23 1.22 1.20 1.19 1.19 1.18 1.17 1.17 1.15 1.13 1.13 1.13 1.13 1.12 1.12 1.12 1.11 1.11 1.10 1.10 1.09 1.08 1.08 1.07 1.07 1.07 1.07
0.77 1.29 1.21 1.90 0.78 0.98 2.17 0.96 2.64 1.56 0.88 1.46 1.13 1.81 1.81 1.27 1.51 1.58 1.31 0.26 1.19 1.23 1.43 1.14 1.16 1.24 0.93 1.72 0.87 0.62 0.87 0.53 0.64 1.06 1.01 0.61 1.68 0.98 0.99 1.04 1.03 1.13 0.81 0.76 1.01 1.75 0.99 1.31 0.79 1.23 0.94 1.03 0.99 0.98 2.61 0.93 0.73 1.04 1.16 1.21 1.05 0.92
ACCEPTED MANUSCRIPT
M AN U
TE D
423.977 433.422 998.461 328.836 688.072 859.908 629.248 517.228 544.41 462.929 591.04 392.809 440.371 365.488 574.124 653.701 431.561 496.608 496.32 702.222 662.805 484.176 416.81 546.777 645.934 442.885 607.842 676.59 500.913 443.017 556.199 568.581 349.145 533.062 382.852 490.654 1020.09 457.544 417.366 576.447 610.667 1141.9 800.704 359.174 438.174 590.076 504.744 506.088 543.077 795.406 595.466 520.394 586.4 213.544 589.686 388.198 666.511 298.865 239.253 342.212 337.386 483.576
528.442 515.316 1196.81 343.509 546.894 962.707 625.335 601.846 678.693 523.007 677.799 356.778 502.081 413.616 668.185 640.386 507.217 600.656 606.501 768.043 750.559 511.038 437.058 558.695 720.508 439.489 760.245 625.316 575.601 503.919 635.151 677.826 364.978 686.144 390.987 447.944 1073.13 518.673 426.511 473.842 521.749 1011.71 872.906 351.637 482.898 541.173 520.793 443.276 397.382 703.75 674.325 531.815 502.402 183.53 468.769 682.09 1266.17 620.56 389.993 616.768 586.31 841.533
RI PT
461.285 453.468 960.621 288.411 542.306 846.564 534.527 521.577 633.436 449.844 646.733 320.177 476.614 472.661 630.902 601.752 498.665 600.556 472.663 761.768 694.502 529.784 416.123 602.587 610.397 403.181 713.868 560.965 601.157 515.864 613.034 641.729 323.077 710.013 361.914 505.574 1021.12 478.986 462.154 431.585 689.569 1090.74 1038.67 427.644 538.2 548.328 624.602 450.387 411.07 793.153 780.836 578.741 547.954 270.75 633.604 353.618 560.828 402.966 263.323 473.775 367.905 545.969
SC
NH2L1_MOUSE NHP2-like protein 1 11 NUP98_MOUSE Nuclear pore complex protein Nup98-Nup96 11 RM12_MOUSE 39S ribosomal protein L12, mitochondrial 11 SMCE1_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily11 E member 1 G3BP2_MOUSE Ras GTPase-activating protein-binding protein 2 11 ORN_MOUSE Oligoribonuclease, mitochondrial 11 HOOK3_MOUSE Protein Hook homolog 3 11 NDUA8_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 11 NB5R1_MOUSE NADH-cytochrome b5 reductase 1 11 NDUS4_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 11 ELP1_MOUSE Elongator complex protein 1 11 TBB6_MOUSE Tubulin beta-6 chain 11 AKAP1_MOUSE A-kinase anchor protein 1, mitochondrial 11 EMC2_MOUSE ER membrane protein complex subunit 2 11 DYR_MOUSE Dihydrofolate reductase 11 UAP1_MOUSE UDP-N-acetylhexosamine pyrophosphorylase 11 NDUS3_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial 11 AFG31_MOUSE AFG3-like protein 1 11 GRAP1_MOUSE GRIP1-associated protein 1 11 RL27_MOUSE 60S ribosomal protein L27 11 AAPK1_MOUSE 5'-AMP-activated protein kinase catalytic subunit alpha-1 11 MTNB_MOUSE Methylthioribulose-1-phosphate dehydratase 11 F6ZFU0_MOUSE Elongation factor 1-delta (Fragment) 11 BACH_MOUSE Cytosolic acyl coenzyme A thioester hydrolase 11 ATX2L_MOUSE Ataxin-2-like protein 11 GLRX1_MOUSE Glutaredoxin-1 11 HEM3_MOUSE Porphobilinogen deaminase 11 ELOB_MOUSE Transcription elongation factor B polypeptide 2 11 DX39B_MOUSE Spliceosome RNA helicase Ddx39b 11 ANR17_MOUSE Ankyrin repeat domain-containing protein 17 11 MIMIT_MOUSE Mimitin, mitochondrial 11 DYST_MOUSE Dystonin 11 NNRD_MOUSE ATP-dependent (S)-NAD(P)H-hydrate dehydratase 11 PDXK_MOUSE Pyridoxal kinase 11 PSMD4_MOUSE 26S proteasome non-ATPase regulatory subunit 4 11 PIPNA_MOUSE Phosphatidylinositol transfer protein alpha isoform 11 THOC4_MOUSE THO complex subunit 4 11 RBM26_MOUSE RNA-binding protein 26 11 ARP3_MOUSE Actin-related protein 3 11 HNRDL_MOUSE Heterogeneous nuclear ribonucleoprotein D-like 11 SYNC_MOUSE Asparagine--tRNA ligase, cytoplasmic 11 SGTA_MOUSE Small glutamine-rich tetratricopeptide repeat-containing protein alpha 11 MPPA_MOUSE Mitochondrial-processing peptidase subunit alpha 11 CTBP1_MOUSE C-terminal-binding protein 1 11 D3Z0K8_MOUSE Thioredoxin reductase 2, mitochondrial 11 CYTB_MOUSE Cystatin-B 11 PSIP1_MOUSE PC4 and SFRS1-interacting protein 11 LEG3_MOUSE Galectin-3 11 ATX2_MOUSE Ataxin-2 11 TFAM_MOUSE Transcription factor A, mitochondrial 11 KAT1_MOUSE Kynurenine--oxoglutarate transaminase 1 11 FA13A_MOUSE Protein FAM13A 11 PININ_MOUSE Pinin 11 SERB_MOUSE Phosphoserine phosphatase 11 TCP4_MOUSE Activated RNA polymerase II transcriptional coactivator p15 11 GSTK1_MOUSE Glutathione S-transferase kappa 1 10 NDUF4_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 10 CO5A2_MOUSE Collagen alpha-2(V) chain 10 S27A1_MOUSE Long-chain fatty acid transport protein 1 10 KAT3_MOUSE Kynurenine--oxoglutarate transaminase 3 10 AT1B3_MOUSE Sodium/potassium-transporting ATPase subunit beta-3 10 SRPRB_MOUSE Signal recognition particle receptor subunit beta 10
EP
Nhp2l1 Nup98 Mrpl12 Smarce1 G3bp2 Rexo2 Hook3 Ndufa8 Cyb5r1 Ndufs4 Ikbkap Tubb6 Akap1 Emc2 Dhfr Uap1 Ndufs3 Afg3l1 Gripap1 Rpl27 Prkaa1 Apip Eef1d Acot7 Atxn2l Glrx Hmbs Tceb2 Ddx39b Ankrd17 Ndufaf2 Dst Carkd Pdxk Psmd4 Pitpna Alyref Rbm26 Actr3 Hnrnpdl Nars Sgta Pmpca Ctbp1 Txnrd2 Cstb Psip1 Lgals3 Atxn2 Tfam Ccbl1 Fam13a Pnn Psph Sub1 Gstk1 Ndufaf4 Col5a2 Slc27a1 Ccbl2 Atp1b3 Srprb
AC C
sp|Q9D0T1|NH2L1_MOUSE sp|Q6PFD9|NUP98_MOUSE sp|Q9DB15|RM12_MOUSE sp|O54941|SMCE1_MOUSE sp|P97379|G3BP2_MOUSE sp|Q9D8S4|ORN_MOUSE sp|Q8BUK6|HOOK3_MOUSE sp|Q9DCJ5|NDUA8_MOUSE sp|Q9DB73|NB5R1_MOUSE sp|Q9CXZ1|NDUS4_MOUSE sp|Q7TT37|ELP1_MOUSE sp|Q922F4|TBB6_MOUSE sp|O08715|AKAP1_MOUSE sp|Q9CRD2|EMC2_MOUSE sp|P00375|DYR_MOUSE sp|Q91YN5|UAP1_MOUSE sp|Q9DCT2|NDUS3_MOUSE sp|Q920A7|AFG31_MOUSE sp|Q8VD04|GRAP1_MOUSE sp|P61358|RL27_MOUSE sp|Q5EG47|AAPK1_MOUSE sp|Q9WVQ5|MTNB_MOUSE tr|F6ZFU0|F6ZFU0_MOUSE sp|Q91V12|BACH_MOUSE sp|Q7TQH0|ATX2L_MOUSE sp|Q9QUH0|GLRX1_MOUSE sp|P22907|HEM3_MOUSE sp|P62869|ELOB_MOUSE sp|Q9Z1N5|DX39B_MOUSE sp|Q99NH0|ANR17_MOUSE sp|Q59J78|MIMIT_MOUSE sp|Q91ZU6|DYST_MOUSE sp|Q9CZ42|NNRD_MOUSE sp|Q8K183|PDXK_MOUSE sp|O35226|PSMD4_MOUSE sp|P53810|PIPNA_MOUSE sp|O08583|THOC4_MOUSE sp|Q6NZN0|RBM26_MOUSE sp|Q99JY9|ARP3_MOUSE sp|Q9Z130|HNRDL_MOUSE sp|Q8BP47|SYNC_MOUSE sp|Q8BJU0|SGTA_MOUSE sp|Q9DC61|MPPA_MOUSE sp|O88712|CTBP1_MOUSE tr|D3Z0K8|D3Z0K8_MOUSE sp|Q62426|CYTB_MOUSE sp|Q99JF8|PSIP1_MOUSE sp|P16110|LEG3_MOUSE sp|O70305|ATX2_MOUSE sp|P40630|TFAM_MOUSE sp|Q8BTY1|KAT1_MOUSE sp|Q8BGI4|FA13A_MOUSE sp|O35691|PININ_MOUSE sp|Q99LS3|SERB_MOUSE sp|P11031|TCP4_MOUSE sp|Q9DCM2|GSTK1_MOUSE sp|Q9D1H6|NDUF4_MOUSE sp|Q3U962|CO5A2_MOUSE sp|Q60714|S27A1_MOUSE sp|Q71RI9|KAT3_MOUSE sp|P97370|AT1B3_MOUSE sp|P47758|SRPRB_MOUSE
417.019 431.839 880.996 311.042 757.819 843.287 592.96 483.274 547.638 421.493 602.233 380.005 442.685 446.775 568.147 647.27 439.895 516.412 378.604 715.196 621.21 513.105 390.696 581.148 524.277 391.059 530.188 579.523 497.325 428.658 494.544 488.83 282.847 511.139 312.101 488.396 845.125 361.367 391.736 459.029 662.88 1011.62 773.193 344.881 375.373 456.185 465.647 387.871 422.58 640.935 476.608 378.62 425.79 162.213 336.489 552.023 754.71 408.48 334.512 548.692 418.599 613.477
1053.01 455.837 564.432 417.484 482.9 603.336 511.885 535.368 646.343 463.412 710.419 1044.69 489.588 390.155 649.755 666.278 423.239 326.496 363.761 609.457 822.294 398.95 426.255 668.641 600.842 1106.77 1377.1 496.132 1229.25 643.569 395.938 572.731 703.178 582.94 455.045 412.721 638.27 379.117 708.278 429.199 936.576 872.541 637.495 588.668 372.94 678.067 681.258 480.479 690.828 659.819 1163.41 202.243 320.566 810.841 549.617 518.638 642.491 192.04 155.075 395.534 590.618 1084.03
885.855 790.168 1688.52 616.067 1156.08 1495.28 718.008 718.68 482.379 689.712 456.617 1456.88 812.962 404.612 799.587 589.772 341.373 627.503 791.39 825.197 607.59 929.595 1191.38 607.717 767.031 3152.44 1237.05 1013.22 806.934 745.648 585.991 642.62 1024.7 633.74 817.457 655.099 1114.36 509.041 620.974 1072.07 649.771 1933.78 1319.28 631.142 432.133 1262.87 865.024 888.361 1481.81 1296.46 953.027 933.491 709.086 1100.8 806.005 497.05 825.566 241.074 178.528 476.257 519.721 1439.29
1.07 1.07 1.06 1.06 1.06 1.06 1.05 1.04 1.04 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.02 1.02 1.02 1.01 1.01 1.01 0.99 0.99 0.99 0.98 0.98 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.94 0.94 0.94 0.94 0.93 0.93 0.91 0.91 0.89 0.89 0.88 0.88 0.87 0.87 0.86 0.85 0.84 0.83 0.82 0.71 0.66 1.66 1.65 1.47 1.44 1.43 1.42 1.41
2.19 1.40 1.15 1.67 1.33 1.23 1.06 1.21 0.96 1.26 0.94 3.51 1.42 0.95 1.20 1.00 0.82 0.87 1.19 0.98 1.05 1.31 1.94 1.11 1.09 5.03 1.98 1.22 1.85 1.45 0.84 1.00 2.57 0.98 1.71 1.07 0.86 0.95 1.51 1.49 1.22 1.26 1.06 1.55 0.82 1.70 1.37 1.43 2.28 1.23 1.54 1.03 0.91 3.95 1.11 1.37 1.20 0.62 0.66 1.07 1.57 2.45
ACCEPTED MANUSCRIPT
TE D
595.39 872.977 357.545 241.082 563.542 403.163 396.761 381.69 495.331 427.673 511.789 419.23 345.014 307.029 455.363 406.444 476.591 525.653 482.569 680.116 541.984 459.568 486 439.893 495.878 582.448 316.406 667.161 543.116 463.052 456.055 568.015 717.075 518.017 734.059 468.489 427.175 343.39 432.523 583.905 660.955 291.212 416.696 555.253 429.415 330.427 248.03 603.874 402.482 474.646 439.627 448.489 803.801 614.867 473.3 479.79 412.759 448.326 315.655 348.969 340.703 468.331
724.189 851.086 580.42 412.112 851.523 658.43 442.788 581.35 814.705 568.222 806.886 579.305 588.272 464.044 699.13 487.804 779.939 498.919 664.168 984.757 666.975 637.526 512.775 606.431 648.039 787.238 457.401 878.695 497.316 478.247 590.029 634.706 985.543 716.361 761.037 576.871 575.266 430.279 557.274 728.72 770.934 364.716 581.742 632.649 474.951 435.85 300.248 738.18 525.762 561.397 484.163 522.726 859.724 666.328 456.254 587.351 463.708 582.528 401.304 396.619 403.145 535.598
RI PT
455.841 720.513 380.902 264.544 563.504 445.042 252.449 425.003 524.267 407.169 594.908 420.216 443.708 335.284 588.989 363.044 667.026 422.933 559.269 780.625 524.319 504.448 430.356 511.435 483.549 692.773 365.682 708.348 446.368 469.923 489.208 475.905 800.041 629.526 642.57 526.07 511.617 385.593 500.351 541.7 643.235 294.452 515.299 497.624 446.015 442.585 275.539 682.558 422.05 497.396 403.134 480.99 874.903 591.567 396.934 520.735 410.406 491.561 375.639 414.797 368.741 519.232
SC
10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
M AN U
HPT_MOUSE Haptoglobin SFPQ_MOUSE Splicing factor, proline- and glutamine-rich AT1A2_MOUSE Sodium/potassium-transporting ATPase subunit alpha-2 CSRP1_MOUSE Cysteine and glycine-rich protein 1 TECR_MOUSE Very-long-chain enoyl-CoA reductase PGBM_MOUSE Basement membrane-specific heparan sulfate proteoglycan core protein RL12_MOUSE 60S ribosomal protein L12 K6PF_MOUSE 6-phosphofructokinase, muscle type S10AA_MOUSE Protein S100-A10 AMACR_MOUSE Alpha-methylacyl-CoA racemase T120A_MOUSE Transmembrane protein 120A RBGPR_MOUSE Rab3 GTPase-activating protein non-catalytic subunit MCCB_MOUSE Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial ARFG2_MOUSE ADP-ribosylation factor GTPase-activating protein 2 DHTK1_MOUSE Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial MECR_MOUSE Trans-2-enoyl-CoA reductase, mitochondrial BAZ1B_MOUSE Tyrosine-protein kinase BAZ1B S10A6_MOUSE Protein S100-A6 LIPB1_MOUSE Liprin-beta-1 PSMD8_MOUSE 26S proteasome non-ATPase regulatory subunit 8 NSF_MOUSE Vesicle-fusing ATPase NUP88_MOUSE Nuclear pore complex protein Nup88 LIMA1_MOUSE LIM domain and actin-binding protein 1 G3X922_MOUSE MCG115602 RM41_MOUSE 39S ribosomal protein L41, mitochondrial LACTB_MOUSE Serine beta-lactamase-like protein LACTB, mitochondrial ARFG3_MOUSE ADP-ribosylation factor GTPase-activating protein 3 RB3GP_MOUSE Rab3 GTPase-activating protein catalytic subunit PCNA_MOUSE Proliferating cell nuclear antigen GMDS_MOUSE GDP-mannose 4,6 dehydratase GAR1_MOUSE H/ACA ribonucleoprotein complex subunit 1 NUP50_MOUSE Nuclear pore complex protein Nup50 COASY_MOUSE Bifunctional coenzyme A synthase MIRO1_MOUSE Mitochondrial Rho GTPase 1 TIM10_MOUSE Mitochondrial import inner membrane translocase subunit Tim10 MTA2_MOUSE Metastasis-associated protein MTA2 UBA6_MOUSE Ubiquitin-like modifier-activating enzyme 6 HMOX2_MOUSE Heme oxygenase 2 AL3A2_MOUSE Fatty aldehyde dehydrogenase ISCU_MOUSE Iron-sulfur cluster assembly enzyme ISCU, mitochondrial DJB11_MOUSE DnaJ homolog subfamily B member 11 PPAC_MOUSE Low molecular weight phosphotyrosine protein phosphatase SAHH2_MOUSE Putative adenosylhomocysteinase 2 TIM9_MOUSE Mitochondrial import inner membrane translocase subunit Tim9 PSD13_MOUSE 26S proteasome non-ATPase regulatory subunit 13 SAM50_MOUSE Sorting and assembly machinery component 50 homolog IMA3_MOUSE Importin subunit alpha-3 SYDC_MOUSE Aspartate--tRNA ligase, cytoplasmic H15_MOUSE Histone H1.5 SMRC2_MOUSE SWI/SNF complex subunit SMARCC2 NAA50_MOUSE Isoform 2 of N-alpha-acetyltransferase 50 DRS7B_MOUSE Dehydrogenase/reductase SDR family member 7B RS24_MOUSE 40S ribosomal protein S24 FKBP2_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP2 CSK2B_MOUSE Casein kinase II subunit beta NTKL_MOUSE N-terminal kinase-like protein SRSF6_MOUSE Serine/arginine-rich splicing factor 6 DLG1_MOUSE Disks large homolog 1 FLOT2_MOUSE Flotillin-2 AIFM2_MOUSE Apoptosis-inducing factor 2 NFS1_MOUSE Cysteine desulfurase, mitochondrial SIL1_MOUSE Nucleotide exchange factor SIL1
EP
Hp Sfpq Atp1a2 Csrp1 Tecr Hspg2 Rpl12 Pfkm S100a10 Amacr Tmem120a Rab3gap2 Mccc2 Arfgap2 Dhtkd1 Mecr Baz1b S100a6 Ppfibp1 Psmd8 Nsf Nup88 Lima1 Dnajc13 Mrpl41 Lactb Arfgap3 Rab3gap1 Pcna Gmds Gar1 Nup50 Coasy Rhot1 Timm10 Mta2 Uba6 Hmox2 Aldh3a2 Iscu Dnajb11 Acp1 Ahcyl1 Timm9 Psmd13 Samm50 Kpna4 Dars Hist1h1b Smarcc2 Naa50 Dhrs7b Rps24 Fkbp2 Csnk2b Scyl1 Srsf6 Dlg1 Flot2 Aifm2 Nfs1 Sil1
AC C
sp|Q61646|HPT_MOUSE sp|Q8VIJ6|SFPQ_MOUSE sp|Q6PIE5|AT1A2_MOUSE sp|P97315|CSRP1_MOUSE sp|Q9CY27|TECR_MOUSE sp|Q05793|PGBM_MOUSE sp|P35979|RL12_MOUSE sp|P47857|K6PF_MOUSE sp|P08207|S10AA_MOUSE sp|O09174|AMACR_MOUSE sp|Q8C1E7|T120A_MOUSE sp|Q8BMG7|RBGPR_MOUSE sp|Q3ULD5|MCCB_MOUSE sp|Q99K28|ARFG2_MOUSE sp|A2ATU0|DHTK1_MOUSE sp|Q9DCS3|MECR_MOUSE sp|Q9Z277|BAZ1B_MOUSE sp|P14069|S10A6_MOUSE sp|Q8C8U0|LIPB1_MOUSE sp|Q9CX56|PSMD8_MOUSE sp|P46460|NSF_MOUSE sp|Q8CEC0|NUP88_MOUSE sp|Q9ERG0|LIMA1_MOUSE tr|G3X922|G3X922_MOUSE sp|Q9CQN7|RM41_MOUSE sp|Q9EP89|LACTB_MOUSE sp|Q9D8S3|ARFG3_MOUSE sp|Q80UJ7|RB3GP_MOUSE sp|P17918|PCNA_MOUSE sp|Q8K0C9|GMDS_MOUSE sp|Q9CY66|GAR1_MOUSE sp|Q9JIH2|NUP50_MOUSE sp|Q9DBL7|COASY_MOUSE sp|Q8BG51|MIRO1_MOUSE sp|P62073|TIM10_MOUSE sp|Q9R190|MTA2_MOUSE sp|Q8C7R4|UBA6_MOUSE sp|O70252|HMOX2_MOUSE sp|P47740|AL3A2_MOUSE sp|Q9D7P6|ISCU_MOUSE sp|Q99KV1|DJB11_MOUSE sp|Q9D358|PPAC_MOUSE sp|Q80SW1|SAHH2_MOUSE sp|Q9WV98|TIM9_MOUSE sp|Q9WVJ2|PSD13_MOUSE sp|Q8BGH2|SAM50_MOUSE sp|O35343|IMA3_MOUSE sp|Q922B2|SYDC_MOUSE sp|P43276|H15_MOUSE sp|Q6PDG5|SMRC2_MOUSE sp|Q6PGB6-2|NAA50_MOUSE sp|Q99J47|DRS7B_MOUSE sp|P62849|RS24_MOUSE sp|P45878|FKBP2_MOUSE sp|P67871|CSK2B_MOUSE sp|Q9EQC5|NTKL_MOUSE sp|Q3TWW8|SRSF6_MOUSE sp|Q811D0|DLG1_MOUSE sp|Q60634|FLOT2_MOUSE sp|Q8BUE4|AIFM2_MOUSE sp|Q9Z1J3|NFS1_MOUSE sp|Q9EPK6|SIL1_MOUSE
758.63 1392.79 448.325 281.707 671.893 481.44 421.676 466.45 501.127 494.283 597.81 483.617 389.076 325.491 581.745 454.013 613.006 644.263 585.261 766.508 610.956 505.86 571.509 515.988 507.509 707.968 331.529 705.126 634.767 587.813 489.744 554.901 728.704 570.708 779.004 530.538 457.171 367.28 459.589 496.73 637.997 267.326 422.403 498.559 465.434 392.462 257.309 629.496 348.643 466.968 406.693 459.544 908.896 599.73 454.033 459.169 396.084 395.575 316.12 395.544 331.365 479.335
307.929 1372 540.318 747.046 523.394 435.38 696.876 753.162 273.357 602.523 850.459 576.631 495.386 236.453 366.124 507.246 365.014 605.552 517.343 881.858 694.192 797.712 660.654 479.407 184.407 385.445 402.317 657.4 614.859 628.173 460.617 638.373 540.271 936.307 563.209 607.162 765.685 400.985 662.018 340.912 625.256 964.914 486.269 473.842 925.153 1056.87 597.326 730.038 1114.28 744.633 481.076 444.891 887.515 487.763 490.5 1000.1 258.557 480.353 455.217 497.769 264.545 424.773
984.945 1282.17 465.496 1359.86 571.698 489.609 724.401 563.608 323.295 574.636 569.93 457.422 660.235 508.992 520.353 641.797 295.657 756.454 855.372 526.679 551.504 572.191 1050.9 427.473 581.803 502.604 485.452 597.489 952.393 502.446 461.559 1110.95 617.948 636.188 1235.56 589.433 474.379 474.981 454.309 1404.99 820.542 1818.17 446.404 932.59 628.423 675.245 557.766 503.717 704.2 1109.16 570.649 415.602 1055.66 1003.35 609.448 832.647 715.265 780.343 531.744 557.072 530.301 411.246
1.41 1.41 1.39 1.37 1.35 1.34 1.33 1.30 1.29 1.27 1.27 1.27 1.24 1.23 1.23 1.22 1.22 1.21 1.20 1.20 1.20 1.19 1.18 1.18 1.18 1.17 1.16 1.15 1.14 1.14 1.14 1.14 1.13 1.12 1.12 1.11 1.10 1.09 1.09 1.09 1.08 1.08 1.08 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.04 1.03
1.23 1.67 1.36 4.17 0.97 1.09 2.19 1.63 0.59 1.41 1.28 1.23 1.47 1.16 0.85 1.49 0.58 1.44 1.32 0.96 1.17 1.42 1.87 0.95 0.78 0.70 1.30 0.91 1.58 1.21 0.98 1.68 0.76 1.37 1.31 1.20 1.32 1.20 1.20 1.55 1.11 4.75 1.00 1.34 1.77 2.24 2.21 0.96 2.21 1.91 1.25 0.93 1.16 1.24 1.26 1.83 1.18 1.34 1.43 1.38 1.12 0.85
ACCEPTED MANUSCRIPT
Trmt10c Atpaf1 Thop1 Ubfd1 Add3 Ubqln1 Anp32e Nap1l4 Luc7l3 Zranb2 Atp2b1 Ifi204 Myo6 Epb41l3 Sec22b Nsdhl Vwa5a
430.82 374.812 453.459 490.495 738.976 589.315 447.971 456.037 545.155 340.106 439.105 397.691 649.576 804.485 623.472 653.798 517.84 375.223 322.443 659.554 460.901 380.167 453.632 385.546 489.774 496.881 307.3 673.261 397.591 545.383 601.986 520.393 390.314 793.941 418.985 510.04 319.021 452.339 518.395 799.518 626.322 428.709 634.14 562.13 457.487 501.689 544.49 548.33 575.284 465.276 728.452 434.006 404.914 403.916 675.976 370.366 238.108 371.355 426.364 512.186 525.042 447.479
447.11 473.49 552.6 646.108 729.857 506.118 446.41 439.887 680.38 359.6 433.005 544.677 620.075 734.175 607.239 625.951 491.537 401.505 391.253 456.746 465.479 418.301 423.615 410.477 369.813 581.598 304.246 685.748 458.151 619.517 644.044 486.821 379.183 766.173 404.397 480.158 344.073 421.708 438.545 674.814 697.74 398.798 658.564 552.839 426.74 521.253 494.876 591.68 510.146 539.152 701.784 373.685 332.823 346.732 391.281 612.472 366.426 621.49 614.445 730.685 744.532 714.864
RI PT
393.103 476.187 565.174 608.71 582.495 459.925 373.707 396.994 674.35 310.455 410.494 538.757 503.619 714.031 545.474 553.518 421.009 393.099 434.204 366.769 379.445 404.414 519.889 470.534 416.176 620.359 274.019 700.869 461.331 682.274 716.218 451.14 371.483 743.953 399.198 471.306 376.239 440.066 445.733 631.902 790.179 424.419 766.34 631.497 571.055 555.608 582.853 710.986 527.303 615.495 681.97 385.325 359.328 424.179 545.054 428.636 256.962 386.302 484.156 494.852 528.764 528.547
SC
10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 9 9 9 9 9 9 9
M AN U
TE D
Stam2 Naga Ppm1a Snrpd3 Fkbp5
DNJC2_MOUSE DnaJ homolog subfamily C member 2 SPT6H_MOUSE Transcription elongation factor SPT6 SEPT6_MOUSE Septin-6 ZNT9_MOUSE Zinc transporter 9 MTPN_MOUSE Myotrophin BOLA3_MOUSE BolA-like protein 3 TTC1_MOUSE Tetratricopeptide repeat protein 1 ZPR1_MOUSE Zinc finger protein ZPR1 CLPB_MOUSE Caseinolytic peptidase B protein homolog CANB1_MOUSE Calcineurin subunit B type 1 PCNP_MOUSE PEST proteolytic signal-containing nuclear protein PUR4_MOUSE Phosphoribosylformylglycinamidine synthase RANG_MOUSE Ran-specific GTPase-activating protein AKT2_MOUSE RAC-beta serine/threonine-protein kinase SNP29_MOUSE Synaptosomal-associated protein 29 GMFB_MOUSE Glia maturation factor beta GOGA4_MOUSE Golgin subfamily A member 4 E9QKT1_MOUSE Ubiquitin-protein ligase E3A SPT5H_MOUSE Transcription elongation factor SPT5 SWI5_MOUSE DNA repair protein SWI5 homolog NUP62_MOUSE Nuclear pore glycoprotein p62 B7ZC46_MOUSE Septin-8 NONO_MOUSE Non-POU domain-containing octamer-binding protein PR40A_MOUSE Pre-mRNA-processing factor 40 homolog A SPD2A_MOUSE SH3 and PX domain-containing protein 2A PGM2_MOUSE Phosphoglucomutase-2 NFU1_MOUSE NFU1 iron-sulfur cluster scaffold homolog, mitochondrial PUF60_MOUSE Poly(U)-binding-splicing factor PUF60 SNX9_MOUSE Sorting nexin-9 ARL8A_MOUSE ADP-ribosylation factor-like protein 8A ILF2_MOUSE Interleukin enhancer-binding factor 2 CDC26_MOUSE Anaphase-promoting complex subunit CDC26 DNJC7_MOUSE DnaJ homolog subfamily C member 7 FUT11_MOUSE Alpha-(1,3)-fucosyltransferase 11 PP4R2_MOUSE Serine/threonine-protein phosphatase 4 regulatory subunit 2 CLIC1_MOUSE Chloride intracellular channel protein 1 ARPC3_MOUSE Actin-related protein 2/3 complex subunit 3 CASP8_MOUSE Caspase-8 CF203_MOUSE Uncharacterized protein C6orf203 homolog STAM2_MOUSE Signal transducing adapter molecule 2 NAGAB_MOUSE Alpha-N-acetylgalactosaminidase PPM1A_MOUSE Protein phosphatase 1A SMD3_MOUSE Small nuclear ribonucleoprotein Sm D3 FKBP5_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP5 CB047_MOUSE Uncharacterized protein C2orf47 homolog, mitochondrial MRRP1_MOUSE Mitochondrial ribonuclease P protein 1 ATPF1_MOUSE ATP synthase mitochondrial F1 complex assembly factor 1 THOP1_MOUSE Thimet oligopeptidase UBFD1_MOUSE Ubiquitin domain-containing protein UBFD1 ADDG_MOUSE Isoform 1 of Gamma-adducin UBQL1_MOUSE Ubiquilin-1 AN32E_MOUSE Acidic leucine-rich nuclear phosphoprotein 32 family member E NP1L4_MOUSE Nucleosome assembly protein 1-like 4 LC7L3_MOUSE Luc7-like protein 3 ZRAB2_MOUSE Zinc finger Ran-binding domain-containing protein 2 G5E829_MOUSE MCG13663, isoform CRA_a IFI4_MOUSE Interferon-activable protein 204 E9PVU0_MOUSE Unconventional myosin-VI E41L3_MOUSE Isoform 3 of Band 4.1-like protein 3 SC22B_MOUSE Vesicle-trafficking protein SEC22b NSDHL_MOUSE Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating VMA5A_MOUSE von Willebrand factor A domain-containing protein 5A
EP
Dnajc2 Supt6h Septin6 Slc30a9 Mtpn Bola3 Ttc1 Zpr1 Clpb Ppp3r1 Pcnp Pfas Ranbp1 Akt2 Snap29 Gmfb Golga4 Ube3a Supt5h Swi5 Nup62 septin8 Nono Prpf40a Sh3pxd2a Pgm2 Nfu1 Puf60 Snx9 Arl8a Ilf2 Cdc26 Dnajc7 Fut11 Ppp4r2 Clic1 Arpc3 Casp8
AC C
sp|P54103|DNJC2_MOUSE sp|Q62383|SPT6H_MOUSE sp|Q9R1T4|SEPT6_MOUSE sp|Q5IRJ6|ZNT9_MOUSE sp|P62774|MTPN_MOUSE sp|Q8CEI1|BOLA3_MOUSE sp|Q91Z38|TTC1_MOUSE sp|Q62384|ZPR1_MOUSE sp|Q60649|CLPB_MOUSE sp|Q63810|CANB1_MOUSE sp|Q6P8I4|PCNP_MOUSE sp|Q5SUR0|PUR4_MOUSE sp|P34022|RANG_MOUSE sp|Q60823|AKT2_MOUSE sp|Q9ERB0|SNP29_MOUSE sp|Q9CQI3|GMFB_MOUSE sp|Q91VW5|GOGA4_MOUSE tr|E9QKT1|E9QKT1_MOUSE sp|O55201|SPT5H_MOUSE sp|Q8K3D3|SWI5_MOUSE sp|Q63850|NUP62_MOUSE tr|B7ZC46|B7ZC46_MOUSE sp|Q99K48|NONO_MOUSE sp|Q9R1C7|PR40A_MOUSE sp|O89032|SPD2A_MOUSE sp|Q7TSV4|PGM2_MOUSE sp|Q9QZ23|NFU1_MOUSE sp|Q3UEB3|PUF60_MOUSE sp|Q91VH2|SNX9_MOUSE sp|Q8VEH3|ARL8A_MOUSE sp|Q9CXY6|ILF2_MOUSE sp|Q99JP4|CDC26_MOUSE sp|Q9QYI3|DNJC7_MOUSE sp|Q8BHC9|FUT11_MOUSE sp|Q0VGB7|PP4R2_MOUSE sp|Q9Z1Q5|CLIC1_MOUSE sp|Q9JM76|ARPC3_MOUSE sp|O89110|CASP8_MOUSE sp|Q9CQF4|CF203_MOUSE sp|O88811|STAM2_MOUSE sp|Q9QWR8|NAGAB_MOUSE sp|P49443|PPM1A_MOUSE sp|P62320|SMD3_MOUSE sp|Q64378|FKBP5_MOUSE sp|Q8BHE8|CB047_MOUSE sp|Q3UFY8|MRRP1_MOUSE sp|Q811I0|ATPF1_MOUSE sp|Q8C1A5|THOP1_MOUSE sp|Q78JW9|UBFD1_MOUSE sp|Q9QYB5-2|ADDG_MOUSE sp|Q8R317|UBQL1_MOUSE sp|P97822|AN32E_MOUSE sp|Q78ZA7|NP1L4_MOUSE sp|Q5SUF2|LC7L3_MOUSE sp|Q9R020|ZRAB2_MOUSE tr|G5E829|G5E829_MOUSE sp|P15092|IFI4_MOUSE tr|E9PVU0|E9PVU0_MOUSE sp|Q9WV92-3|E41L3_MOUSE sp|O08547|SC22B_MOUSE sp|Q9R1J0|NSDHL_MOUSE sp|Q99KC8|VMA5A_MOUSE
398.155 399.09 482.192 461.462 598.811 546.811 375.856 412.856 535.373 288.507 410.885 384.149 521.566 765.699 544.622 559.635 429.701 351.771 350.511 539.931 347.655 339.99 511.983 410.772 498.67 488.507 252.395 629.163 363.089 552.959 594.344 423.377 334.495 666.236 356.913 425.568 297.601 400.33 447.313 633.471 593.734 377.184 609.253 518.077 484.864 409.374 496.813 513.059 447.898 393.516 499.162 299.788 286.591 286.11 489.736 511.038 328.511 404.957 599.94 609.466 651.778 573.477
508.076 352.05 377.049 742.86 552.461 337.112 337.75 397.341 546.913 349.547 179.093 521.347 547.411 704.427 257.147 598.417 330.177 452.774 331.049 193.141 545.078 339.125 602.395 513.588 804.507 596.496 318.92 632.409 656.146 667.574 559.282 183.184 412.044 421.508 258.177 729.02 1087.48 1137.54 405.776 577.972 648.341 547.628 543.271 954.74 587.911 390.386 279.547 666.939 346.752 401.458 510.68 456.962 559.69 413.041 792.224 453.548 938.731 526.837 525.515 660.67 351.077 551.489
668.691 358.07 438.076 474.211 1156.39 1186.93 554.338 907.231 755.922 786.051 453.923 387.824 1116.97 718.26 888.136 1330.63 748.557 371.702 339.738 529.052 941.667 463.86 484.192 657.026 919.946 464.961 630.541 907.204 603.867 501.042 520.186 502.01 699.755 677.244 453.509 608.345 728.369 2252.8 758.683 1209.77 392.784 1273.92 793.093 968.2 996.93 352.865 559.952 652.49 684.868 462.255 1479.67 698.467 1135.75 605.079 1898.82 345.654 1094.88 570.789 474.785 471.431 310.551 412.186
1.03 1.03 1.02 1.01 1.01 1.00 1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.94 0.94 0.94 0.93 0.93 0.92 0.92 0.92 0.92 0.91 0.91 0.91 0.91 0.90 0.89 0.88 0.88 0.88 0.87 0.86 0.85 0.82 0.81 0.76 0.72 1.41 1.40 1.35 1.33 1.33 1.33 1.32
1.43 0.83 0.80 1.11 1.29 1.45 1.09 1.53 1.07 1.75 0.75 0.97 1.44 0.94 0.98 1.60 1.15 1.07 0.89 0.70 1.77 1.02 1.12 1.37 1.90 0.95 1.63 1.12 1.47 0.95 0.82 0.71 1.46 0.71 0.87 1.36 2.61 3.80 1.21 1.25 0.73 2.14 0.95 1.61 1.54 0.70 0.74 1.05 0.94 0.80 1.41 1.41 2.22 1.23 2.20 1.00 4.11 1.45 1.10 1.12 0.63 0.99
ACCEPTED MANUSCRIPT
TE D
223.22 319.961 432.024 476.645 570.977 416.791 494.201 267.573 509.722 545.018 366.224 294.715 663.613 382.978 334.678 468.788 286.234 511.02 325.386 598.594 377.294 247.369 424.655 378.314 549.098 620.702 405.968 279.929 382.829 374.559 281.373 414.956 467.372 306.545 564.931 232.082 332.163 494.814 296.174 541.319 384.584 250.937 573.642 383.475 592.287 416.363 276.655 398.967 556.592 348.03 477.216 406.683 578.479 411.739 260.82 544.229 376.805 424.562 412.09 422.901 463.735 634.725
362.486 558.669 642.361 741.05 809.791 704.028 604.437 400.226 737.035 574.751 408.083 381.892 825.979 546.701 456.467 637.332 334.183 673.237 419.135 881.806 513.138 309.957 466.309 504.028 329.798 855.971 515.062 397.022 507.425 448.955 369.647 556.981 549.406 357.842 593.956 284.156 390.573 541.469 379.978 739.305 464.163 344.902 651.925 501.293 718.273 557.616 346.828 503.434 623.841 448.598 523.662 486.862 718.419 447.304 362.508 584.758 429.74 451.702 457.986 484.837 584.595 809.503
RI PT
273.29 431.856 463.981 555.871 696.266 532.301 451.696 323.926 569.246 468.54 331.998 331.257 626.198 412.622 381.227 498.002 228.912 561.295 323.357 712.435 376.199 241.592 383.05 416.199 347.547 668.164 401.559 336.815 445.092 465.078 312.186 485.568 482.63 333.267 454.42 270.955 349.609 538.317 305.847 640.794 396.928 295.178 529.473 384.918 629.534 461.817 288.262 441.64 533.345 388.735 567.413 458.684 674.274 361.97 324.673 503.277 405.124 449.305 481.148 447.682 555.499 680.282
SC
9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9
M AN U
GSH1_MOUSE Glutamate--cysteine ligase catalytic subunit NDUBB_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial H10_MOUSE Histone H1.0 SMHD1_MOUSE Structural maintenance of chromosomes flexible hinge domain-containing protein 1 CD63_MOUSE CD63 antigen GSTA4_MOUSE Glutathione S-transferase A4 PGK2_MOUSE Phosphoglycerate kinase 2 COX41_MOUSE Cytochrome c oxidase subunit 4 isoform 1, mitochondrial TEFM_MOUSE Transcription elongation factor, mitochondrial CS010_MOUSE UPF0556 protein C19orf10 homolog AP2A1_MOUSE AP-2 complex subunit alpha-1 SE1L1_MOUSE Protein sel-1 homolog 1 CNOT1_MOUSE CCR4-NOT transcription complex subunit 1 MAVS_MOUSE Mitochondrial antiviral-signaling protein SSRG_MOUSE Translocon-associated protein subunit gamma Q8BVY0_MOUSE Protein Rsl1d1 TACO1_MOUSE Translational activator of cytochrome c oxidase 1 CAB39_MOUSE Calcium-binding protein 39 FIS1_MOUSE Mitochondrial fission 1 protein UFSP2_MOUSE Ufm1-specific protease 2 RHOC_MOUSE Rho-related GTP-binding protein RhoC SBDS_MOUSE Ribosome maturation protein SBDS TBC8B_MOUSE TBC1 domain family member 8B ANXA3_MOUSE Annexin A3 D3YYM6_MOUSE 40S ribosomal protein S5 (Fragment) ILK_MOUSE Integrin-linked protein kinase PDLI1_MOUSE PDZ and LIM domain protein 1 ECHD3_MOUSE Enoyl-CoA hydratase domain-containing protein 3, mitochondrial PPP5_MOUSE Serine/threonine-protein phosphatase 5 UD16_MOUSE UDP-glucuronosyltransferase 1-6 IMPA3_MOUSE Inositol monophosphatase 3 ESYT2_MOUSE Extended synaptotagmin-2 MTA3_MOUSE Metastasis-associated protein MTA3 QIL1_MOUSE Protein QIL1 LYPA2_MOUSE Acyl-protein thioesterase 2 HNRLL_MOUSE Heterogeneous nuclear ribonucleoprotein L-like PP6R3_MOUSE Serine/threonine-protein phosphatase 6 regulatory subunit 3 ARF6_MOUSE ADP-ribosylation factor 6 HIP1_MOUSE Huntingtin-interacting protein 1 PTBP3_MOUSE Polypyrimidine tract-binding protein 3 ELAV1_MOUSE ELAV-like protein 1 EFTS_MOUSE Elongation factor Ts, mitochondrial RM40_MOUSE 39S ribosomal protein L40, mitochondrial CLPP_MOUSE ATP-dependent Clp protease proteolytic subunit, mitochondrial HSP7E_MOUSE Heat shock 70 kDa protein 14 TIPRL_MOUSE TIP41-like protein GGA1_MOUSE ADP-ribosylation factor-binding protein GGA1 BAG5_MOUSE BAG family molecular chaperone regulator 5 ABCF2_MOUSE ATP-binding cassette sub-family F member 2 CCAR1_MOUSE Cell division cycle and apoptosis regulator protein 1 RL15_MOUSE 60S ribosomal protein L15 EH1L1_MOUSE EH domain-binding protein 1-like protein 1 LMAN2_MOUSE Vesicular integral-membrane protein VIP36 TXD12_MOUSE Thioredoxin domain-containing protein 12 LAP2B_MOUSE Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma NP1L1_MOUSE Nucleosome assembly protein 1-like 1 ADK_MOUSE Adenosine kinase P4HA2_MOUSE Isoform IIa of Prolyl 4-hydroxylase subunit alpha-2 BNIP3_MOUSE BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 PHS2_MOUSE Pterin-4-alpha-carbinolamine dehydratase 2 DNJC3_MOUSE DnaJ homolog subfamily C member 3 IAH1_MOUSE Isoamyl acetate-hydrolyzing esterase 1 homolog
EP
Gclc Ndufb11 H1f0 Smchd1 Cd63 Gsta4 Pgk2 Cox4i1 Tefm D17Wsu104e Ap2a1 Sel1l Cnot1 Mavs Ssr3 Rsl1d1 Taco1 Cab39 Fis1 Ufsp2 Rhoc Sbds Tbc1d8b Anxa3 Rps5 Ilk Pdlim1 Echdc3 Ppp5c Ugt1a6 Impad1 Esyt2 Mta3 Qil1 Lypla2 Hnrnpll Ppp6r3 Arf6 Hip1 Ptbp3 Elavl1 Tsfm Mrpl40 Clpp Hspa14 Tiprl Gga1 Bag5 Abcf2 Ccar1 Rpl15 Ehbp1l1 Lman2 Txndc12 Tmpo Nap1l1 Adk P4ha2 Bnip3 Pcbd2 Dnajc3 Iah1
AC C
sp|P97494|GSH1_MOUSE sp|O09111|NDUBB_MOUSE sp|P10922|H10_MOUSE sp|Q6P5D8|SMHD1_MOUSE sp|P41731|CD63_MOUSE sp|P24472|GSTA4_MOUSE sp|P09041|PGK2_MOUSE sp|P19783|COX41_MOUSE sp|Q5SSK3|TEFM_MOUSE sp|Q9CPT4|CS010_MOUSE sp|P17426|AP2A1_MOUSE sp|Q9Z2G6|SE1L1_MOUSE sp|Q6ZQ08|CNOT1_MOUSE sp|Q8VCF0|MAVS_MOUSE sp|Q9DCF9|SSRG_MOUSE tr|Q8BVY0|Q8BVY0_MOUSE sp|Q8K0Z7|TACO1_MOUSE sp|Q06138|CAB39_MOUSE sp|Q9CQ92|FIS1_MOUSE sp|Q99K23|UFSP2_MOUSE sp|Q62159|RHOC_MOUSE sp|P70122|SBDS_MOUSE sp|A3KGB4|TBC8B_MOUSE sp|O35639|ANXA3_MOUSE tr|D3YYM6|D3YYM6_MOUSE sp|O55222|ILK_MOUSE sp|O70400|PDLI1_MOUSE sp|Q9D7J9|ECHD3_MOUSE sp|Q60676|PPP5_MOUSE sp|Q64435|UD16_MOUSE sp|Q80V26|IMPA3_MOUSE sp|Q3TZZ7|ESYT2_MOUSE sp|Q924K8|MTA3_MOUSE sp|Q8R404|QIL1_MOUSE sp|Q9WTL7|LYPA2_MOUSE sp|Q921F4|HNRLL_MOUSE sp|Q922D4|PP6R3_MOUSE sp|P62331|ARF6_MOUSE sp|Q8VD75|HIP1_MOUSE sp|Q8BHD7|PTBP3_MOUSE sp|P70372|ELAV1_MOUSE sp|Q9CZR8|EFTS_MOUSE sp|Q9Z2Q5|RM40_MOUSE sp|O88696|CLPP_MOUSE sp|Q99M31|HSP7E_MOUSE sp|Q8BH58|TIPRL_MOUSE sp|Q8R0H9|GGA1_MOUSE sp|Q8CI32|BAG5_MOUSE sp|Q99LE6|ABCF2_MOUSE sp|Q8CH18|CCAR1_MOUSE sp|Q9CZM2|RL15_MOUSE sp|Q99MS7|EH1L1_MOUSE sp|Q9DBH5|LMAN2_MOUSE sp|Q9CQU0|TXD12_MOUSE sp|Q61029|LAP2B_MOUSE sp|P28656|NP1L1_MOUSE sp|P55264|ADK_MOUSE sp|Q60716-2|P4HA2_MOUSE sp|O55003|BNIP3_MOUSE sp|Q9CZL5|PHS2_MOUSE sp|Q91YW3|DNJC3_MOUSE sp|Q9DB29|IAH1_MOUSE
289.477 416.869 515.592 568.142 787.677 484.406 579.641 335.316 587.853 664.572 438.611 375.016 730.869 411.243 405.06 522.904 279.66 599.745 349.745 666.202 373.705 261.983 475.87 417.538 709.599 629.347 412.548 310.785 434.905 503.791 296.978 453.31 514.724 356.013 541.229 270.628 361.055 594.495 279.049 554.592 389.171 250.654 549.368 328.6 595.509 386.121 259.204 397.865 537.309 333.71 572.135 419.488 587.409 358.8 246.458 497.363 373.374 434.032 446.53 394.957 442.919 513.569
406.467 337.431 1009.22 651.974 460.013 631.21 749.717 435.491 317.086 495.136 1163.22 307.272 762.285 292.079 453.871 509.927 576.442 528.278 398.14 834.392 1602.63 942.486 574.013 873.493 827.418 662.492 561.833 299.972 556.515 361.589 476.612 559.056 632.443 327.256 972.489 1354.55 889.074 685.335 358.067 601.732 428.957 515.32 219.452 364.383 1048.22 709.284 365.111 344.548 639.815 491.335 465.407 312.34 565.704 291.754 641.858 641.538 500.512 583.597 430.252 466.748 330.93 349.762
308.469 242.548 622.812 533.242 314.165 662.711 554.059 350.034 341.5 487.207 838.914 223.501 580.915 361.506 347.895 372.541 1593.92 458.557 353.744 609.518 1296.97 852.627 555.344 780.807 519.734 715.323 918.1 486.881 441.125 398.13 338.067 396.102 778.105 461.902 1723.93 1145.17 689.757 488.676 403.259 672.06 418.564 1185.92 744.994 435.107 833.747 569.152 505.093 280.761 549.449 654.37 399.782 487.033 559.145 570.12 651.763 1086.78 451.827 461.849 493.683 1022.69 374.445 781.798
1.31 1.30 1.29 1.27 1.26 1.25 1.25 1.24 1.23 1.22 1.21 1.21 1.21 1.20 1.20 1.20 1.19 1.19 1.19 1.18 1.18 1.17 1.17 1.16 1.16 1.15 1.15 1.15 1.14 1.13 1.12 1.12 1.12 1.12 1.11 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09 1.08 1.08 1.07 1.07 1.07 1.07 1.06 1.05 1.05 1.04 1.04 1.04 1.03 1.03 1.01 1.01 1.01 1.01 1.01
1.44 0.77 1.82 1.15 0.61 1.36 1.38 1.33 0.61 0.97 2.87 0.85 1.04 0.82 1.12 0.91 4.21 0.92 1.16 1.10 3.85 3.67 1.40 2.08 1.50 1.07 1.83 1.28 1.20 0.90 1.37 1.06 1.48 1.23 2.65 4.97 2.32 1.14 1.26 1.08 1.08 3.12 0.87 1.04 1.54 1.46 1.54 0.74 1.09 1.56 0.83 0.92 0.90 1.11 2.21 1.65 1.22 1.20 1.03 1.71 0.69 0.86
ACCEPTED MANUSCRIPT
TE D
478.67 463.01 648.119 607.715 736.681 410.11 259.985 315.998 447.997 415.876 371.991 453.049 359.536 351.365 488.833 430.067 625.72 476.643 389.478 495.592 355.333 758.999 572.161 318.457 361.258 421.93 384.189 957.298 297.614 552.82 486.504 605.561 447.491 453.638 297.51 390.981 825.739 292.828 475.044 456.092 386.187 465.902 448.788 699.084 742.695 674.39 451.908 712.51 134.78 403.014 229.467 291.082 555.789 515.307 352.082 286.768 367.907 270.894 271.764 335.959 401.363 354.326
535.686 602.719 720.56 719.758 846.46 396.506 349.541 373.886 449.744 402.159 417.511 503.319 361.521 435.352 569.866 476.436 646.699 535.573 379.999 508.708 365.897 798.229 595.936 336.903 343.744 462.34 402.364 942.242 330.124 532.891 496.106 626.782 425.179 424.293 311.65 330.482 568.303 284.958 462.562 408.073 360.026 304.19 397.998 440.389 647.541 477.221 369.79 924.409 267.564 684.928 353.134 473.426 737.56 861.154 552.212 456.3 654.912 603.448 490.825 425.205 626.31 530
RI PT
507.759 580.844 788.827 660.226 706.407 349.15 334.983 414.455 477.243 359.574 478.126 491.354 351.706 448.429 600.243 454.856 613.003 489.879 363.674 455.003 355.696 667.052 568.664 323.939 331.815 531.481 412.392 868.062 361.897 491.739 508.948 607.903 497.207 453.554 344.362 345.047 561.385 361.825 474.228 545.627 386.423 407.457 487.426 441.436 797.677 604.268 435.287 506.871 163.098 367.007 247.837 313.883 445.509 443.093 374.81 297.927 429.19 419.196 331.422 292.333 389.689 426.926
SC
9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
M AN U
RAB9A_MOUSE Ras-related protein Rab-9A RRF2M_MOUSE Ribosome-releasing factor 2, mitochondrial TPMT_MOUSE Thiopurine S-methyltransferase UCHL5_MOUSE Isoform 2 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 NEDD8_MOUSE NEDD8 TBCA_MOUSE Tubulin-specific chaperone A NDUA2_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 MPC2_MOUSE Mitochondrial pyruvate carrier 2 FACE1_MOUSE CAAX prenyl protease 1 homolog A2AJ72_MOUSE MCG130458 SAHH3_MOUSE Putative adenosylhomocysteinase 3 H1BP3_MOUSE HCLS1-binding protein 3 SLIRP_MOUSE SRA stem-loop-interacting RNA-binding protein, mitochondrial RCC1_MOUSE Regulator of chromosome condensation KHDR1_MOUSE KH domain-containing, RNA-binding, signal transduction-associated protein 1 HPRT_MOUSE Hypoxanthine-guanine phosphoribosyltransferase ACINU_MOUSE Apoptotic chromatin condensation inducer in the nucleus FAM21_MOUSE WASH complex subunit FAM21 PFD2_MOUSE Prefoldin subunit 2 MYCBP_MOUSE C-Myc-binding protein LSM7_MOUSE U6 snRNA-associated Sm-like protein LSm7 RD23B_MOUSE UV excision repair protein RAD23 homolog B LSM4_MOUSE U6 snRNA-associated Sm-like protein LSm4 ARPC5_MOUSE Actin-related protein 2/3 complex subunit 5 Q923F1_MOUSE Chloride channel, nucleotide-sensitive, 1A RMXL1_MOUSE RNA binding motif protein, X-linked-like-1 LYPA1_MOUSE Acyl-protein thioesterase 1 Q9DCC5_MOUSE Cbx3 protein SAFB1_MOUSE Scaffold attachment factor B1 NUCB2_MOUSE Nucleobindin-2 G5E8V9_MOUSE MCG18094 (Fragment) Q9EQC8_MOUSE Papillary renal cell carcinoma (Translocation-associated) 2AAB_MOUSE Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Q9Z1A1_MOUSE Protein Tfg NUP54_MOUSE Nuclear pore complex protein Nup54 CCDC6_MOUSE Coiled-coil domain-containing protein 6 CIRBP_MOUSE Cold-inducible RNA-binding protein EIF3D_MOUSE Eukaryotic translation initiation factor 3 subunit D 2ABA_MOUSE Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform RRAGC_MOUSE Ras-related GTP-binding protein C ARP5L_MOUSE Actin-related protein 2/3 complex subunit 5-like protein ADRM1_MOUSE Proteasomal ubiquitin receptor ADRM1 NDUF7_MOUSE NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 BAG3_MOUSE BAG family molecular chaperone regulator 3 LC7L2_MOUSE Putative RNA-binding protein Luc7-like 2 PMM2_MOUSE Phosphomannomutase 2 ARGL1_MOUSE Arginine and glutamate-rich protein 1 RS10_MOUSE 40S ribosomal protein S10 CGL_MOUSE Cystathionine gamma-lyase VCAM1_MOUSE Vascular cell adhesion protein 1 F6VVY4_MOUSE Protein Slc25a1 (Fragment) NIPS2_MOUSE Protein NipSnap homolog 2 TPM4_MOUSE Tropomyosin alpha-4 chain DHRS1_MOUSE Dehydrogenase/reductase SDR family member 1 SYLM_MOUSE Probable leucine--tRNA ligase, mitochondrial CTNA1_MOUSE Catenin alpha-1 STXB3_MOUSE Syntaxin-binding protein 3 GLGB_MOUSE 1,4-alpha-glucan-branching enzyme ALAT1_MOUSE Alanine aminotransferase 1 TPM3_MOUSE Tropomyosin alpha-3 chain PSB3_MOUSE Proteasome subunit beta type-3 TBRG4_MOUSE Protein TBRG4
EP
Rab9a Gfm2 Tpmt Uchl5 Nedd8 Tbca Ndufa2 Mpc2 Zmpste24 Fubp3 Ahcyl2 Hs1bp3 Slirp Rcc1 Khdrbs1 Hprt1 Acin1 Fam21 Pfdn2 Mycbp Lsm7 Rad23b Lsm4 Arpc5 Clns1a Rbmxl1 Lypla1 Cbx3 Safb Nucb2 Arfip1 Prcc Ppp2r1b Tfg Nup54 Ccdc6 Cirbp Eif3d Ppp2r2a Rragc Arpc5l Adrm1 Ndufaf7 Bag3 Luc7l2 Pmm2 Arglu1 Rps10 Cth Vcam1 Slc25a1 Gbas Tpm4 Dhrs1 Lars2 Ctnna1 Stxbp3 Gbe1 Gpt Tpm3 Psmb3 Tbrg4
AC C
sp|Q9R0M6|RAB9A_MOUSE sp|Q8R2Q4|RRF2M_MOUSE sp|O55060|TPMT_MOUSE sp|Q9WUP7-2|UCHL5_MOUSE sp|P29595|NEDD8_MOUSE sp|P48428|TBCA_MOUSE sp|Q9CQ75|NDUA2_MOUSE sp|Q9D023|MPC2_MOUSE sp|Q80W54|FACE1_MOUSE tr|A2AJ72|A2AJ72_MOUSE sp|Q68FL4|SAHH3_MOUSE sp|Q3TC93|H1BP3_MOUSE sp|Q9D8T7|SLIRP_MOUSE sp|Q8VE37|RCC1_MOUSE sp|Q60749|KHDR1_MOUSE sp|P00493|HPRT_MOUSE sp|Q9JIX8|ACINU_MOUSE sp|Q6PGL7|FAM21_MOUSE sp|O70591|PFD2_MOUSE sp|Q9EQS3|MYCBP_MOUSE sp|Q9CQQ8|LSM7_MOUSE sp|P54728|RD23B_MOUSE sp|Q9QXA5|LSM4_MOUSE sp|Q9CPW4|ARPC5_MOUSE tr|Q923F1|Q923F1_MOUSE sp|Q91VM5|RMXL1_MOUSE sp|P97823|LYPA1_MOUSE tr|Q9DCC5|Q9DCC5_MOUSE sp|D3YXK2|SAFB1_MOUSE sp|P81117|NUCB2_MOUSE tr|G5E8V9|G5E8V9_MOUSE tr|Q9EQC8|Q9EQC8_MOUSE sp|Q7TNP2|2AAB_MOUSE tr|Q9Z1A1|Q9Z1A1_MOUSE sp|Q8BTS4|NUP54_MOUSE sp|D3YZP9|CCDC6_MOUSE sp|P60824|CIRBP_MOUSE sp|O70194|EIF3D_MOUSE sp|Q6P1F6|2ABA_MOUSE sp|Q99K70|RRAGC_MOUSE sp|Q9D898|ARP5L_MOUSE sp|Q9JKV1|ADRM1_MOUSE sp|Q9CWG8|NDUF7_MOUSE sp|Q9JLV1|BAG3_MOUSE sp|Q7TNC4|LC7L2_MOUSE sp|Q9Z2M7|PMM2_MOUSE sp|Q3UL36|ARGL1_MOUSE sp|P63325|RS10_MOUSE sp|Q8VCN5|CGL_MOUSE sp|P29533|VCAM1_MOUSE tr|F6VVY4|F6VVY4_MOUSE sp|O55126|NIPS2_MOUSE sp|Q6IRU2|TPM4_MOUSE sp|Q99L04|DHRS1_MOUSE sp|Q8VDC0|SYLM_MOUSE sp|P26231|CTNA1_MOUSE sp|Q60770|STXB3_MOUSE sp|Q9D6Y9|GLGB_MOUSE sp|Q8QZR5|ALAT1_MOUSE sp|P21107|TPM3_MOUSE sp|Q9R1P1|PSB3_MOUSE sp|Q91YM4|TBRG4_MOUSE
454.833 441.021 714.431 535.833 571.321 349.307 234.74 343.365 457.672 355.258 410.946 416.376 329.785 341.476 484.895 379.705 546.242 394.487 342.551 401.222 308.205 546.628 474.172 261.641 296.854 409.408 324.733 707.015 262.113 404.374 396.261 451.343 413.909 377.544 253.629 313.237 639.895 285.146 360.999 445.748 270.064 387.494 316.685 426.427 505.219 444.938 264.294 1348.7 259.123 634.85 439.91 495.005 856.129 486.297 458.928 354.669 443.269 337.602 331.565 416.491 406.013 482.384
458.868 518.518 436.412 784.799 495.247 410.855 264.133 863.163 367.205 467.957 931.058 206.241 193.467 517.189 927.35 467.016 355.891 302.447 386.163 282.808 317.744 578.651 459.337 448.2 242.154 279.258 436.594 668.536 423.677 185.284 459.639 347.273 327.438 408.75 354.103 333.909 441.963 886.452 459.66 657.519 316.843 778.334 212.464 432.266 567.429 653.59 386.183 977.766 622.936 182.445 974.168 1065.39 643.768 864.443 525.911 242.516 653.119 786.41 622.309 341.031 534.116 153.176
735.103 1138.39 461.618 1013.22 1033.46 923.385 408.172 806.797 407.444 970.842 930.877 234.388 387.865 450.438 1004.06 469.453 815.214 457.318 728.301 842.263 586.781 1244.01 823.974 545.762 550.854 725.374 696.546 1371.6 614.472 572.027 407.967 420.534 492.391 525.964 320.499 562.952 1006.01 843.626 555.673 580.073 546.845 1194.81 448.495 1091.84 1017.77 1270.57 747.079 701.736 565.993 250.099 589.014 1424.97 1067.36 766.87 545.365 277.888 387.466 610.37 657.438 557.512 396.726 249.908
1.00 1.00 1.00 0.99 0.98 0.98 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.95 0.94 0.94 0.93 0.92 0.91 0.91 0.90 0.90 0.90 0.90 0.89 0.89 0.88 0.88 0.87 0.87 0.87 0.87 0.85 0.82 0.79 0.76 0.76 0.75 0.72 0.71 1.86 1.77 1.71 1.66 1.60 1.59 1.41 1.39 1.39 1.38 1.36 1.36 1.34 1.31 1.30
1.21 1.59 0.62 1.42 1.06 1.76 1.13 2.29 0.84 1.86 2.19 0.47 0.82 1.21 1.77 1.06 0.95 0.79 1.48 1.18 1.27 1.28 1.12 1.55 1.14 1.05 1.42 1.12 1.57 0.73 0.87 0.63 0.87 1.03 1.05 1.22 1.04 2.64 1.07 1.24 1.12 2.26 0.71 1.34 1.03 1.50 1.28 1.38 3.99 0.56 3.28 4.12 1.71 1.70 1.47 0.89 1.31 2.02 2.12 1.43 1.18 0.52
ACCEPTED MANUSCRIPT
TE D
181.55 372.233 295.909 366.544 395.142 281.101 343.556 230.959 239.699 273.585 360.746 277.469 329.029 317.578 549.14 493.625 445.129 536.952 288.133 401.948 310.487 274.732 336.041 487.792 373.92 463.147 319.918 373.017 363.863 313.314 274.345 330.409 248.036 318.804 290.062 191.799 432.475 328.641 401.792 618.255 337.943 351.401 388.858 245.656 269.789 467.251 352.475 247.913 510.069 373.021 478.675 446.803 673.064 270.756 209.239 318.663 364.021 496.587 417.041 547.065 389.231 495.91
280.24 314.555 356.22 537.343 686.572 429.589 431.823 359.29 311.041 382.512 478.267 281.459 398.73 416.011 622.85 530.418 655.448 803.085 372.582 516.822 389.94 389.81 498.601 651.868 493.435 562.361 442.036 556.87 450.059 426.647 341.549 362.016 326.262 569.78 414.022 263.322 536.023 421.423 517.156 849.682 449.999 408.883 450.134 348.965 334.192 581.188 369.509 254.715 633.988 438.517 519.822 501.404 651.684 304.27 251.099 353.999 367.974 582.903 472.621 790.951 319.481 457.972
RI PT
195.102 269.592 269.859 371.295 494.048 304.874 311.11 274.657 251.864 292.348 393.021 241.129 294.395 289.911 508.315 403.675 546.995 640.646 277.308 440.52 317.834 346.83 391.4 539.258 402.38 447.112 372.925 468.861 369.679 338.996 289.418 382.301 293.345 533.102 373.47 235.909 480.671 425.26 477.369 778.521 374.196 366.749 364.917 288.605 287.617 513.496 329.796 211.545 574.167 436.733 465.365 405.785 567.977 316.058 225.252 323.927 452.606 522.335 428.657 738.335 281.936 408.105
SC
8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
M AN U
PDK3_MOUSE [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial NUCKS_MOUSE Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 EXOC4_MOUSE Exocyst complex component 4 TOIP1_MOUSE Torsin-1A-interacting protein 1 LANC1_MOUSE LanC-like protein 1 PO121_MOUSE Nuclear envelope pore membrane protein POM 121 COX5A_MOUSE Cytochrome c oxidase subunit 5A, mitochondrial ADAS_MOUSE Alkyldihydroxyacetonephosphate synthase, peroxisomal PDS5A_MOUSE Sister chromatid cohesion protein PDS5 homolog A SVIL_MOUSE Supervillin CUL5_MOUSE Cullin-5 ATX10_MOUSE Ataxin-10 MCTS2_MOUSE Malignant T-cell-amplified sequence 2 Q3TGS7_MOUSE Sorting nexin 12, isoform CRA_b ACYP2_MOUSE Acylphosphatase-2 EPN4_MOUSE Clathrin interactor 1 ARL8B_MOUSE ADP-ribosylation factor-like protein 8B DDHD2_MOUSE Phospholipase DDHD2 RT36_MOUSE 28S ribosomal protein S36, mitochondrial DHB11_MOUSE Estradiol 17-beta-dehydrogenase 11 MTMR5_MOUSE Myotubularin-related protein 5 OST48_MOUSE Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit KIF1B_MOUSE Kinesin-like protein KIF1B COX15_MOUSE Cytochrome c oxidase assembly protein COX15 homolog DPYL3_MOUSE Dihydropyrimidinase-related protein 3 WNK1_MOUSE Serine/threonine-protein kinase WNK1 SNRPA_MOUSE U1 small nuclear ribonucleoprotein A DYN1_MOUSE Dynamin-1 SAP3_MOUSE Ganglioside GM2 activator MK01_MOUSE Mitogen-activated protein kinase 1 MP2K2_MOUSE Dual specificity mitogen-activated protein kinase kinase 2 GSTM5_MOUSE Glutathione S-transferase Mu 5 DX39A_MOUSE ATP-dependent RNA helicase DDX39A CYTC_MOUSE Cystatin-C PP2BA_MOUSE Isoform 2 of Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform C19L1_MOUSE CWF19-like protein 1 RAB14_MOUSE Ras-related protein Rab-14 SPG7_MOUSE Paraplegin SCLY_MOUSE Selenocysteine lyase RT23_MOUSE 28S ribosomal protein S23, mitochondrial PRS10_MOUSE 26S protease regulatory subunit 10B GPD1L_MOUSE Glycerol-3-phosphate dehydrogenase 1-like protein CBR4_MOUSE Carbonyl reductase family member 4 GOGA5_MOUSE Golgin subfamily A member 5 A2AIX1_MOUSE Protein Sec16a RM39_MOUSE 39S ribosomal protein L39, mitochondrial RAB18_MOUSE Ras-related protein Rab-18 LPP_MOUSE Lipoma-preferred partner homolog RL38_MOUSE 60S ribosomal protein L38 ABCB7_MOUSE ATP-binding cassette sub-family B member 7, mitochondrial NENF_MOUSE Neudesin IBP7_MOUSE Insulin-like growth factor-binding protein 7 UBE2K_MOUSE Ubiquitin-conjugating enzyme E2 K PEX3_MOUSE Peroxisomal biogenesis factor 3 IMA4_MOUSE Importin subunit alpha-4 CCHL_MOUSE Cytochrome c-type heme lyase MTCH1_MOUSE Mitochondrial carrier homolog 1 OGFR_MOUSE Opioid growth factor receptor PHLB1_MOUSE Pleckstrin homology-like domain family B member 1 MCES_MOUSE mRNA cap guanine-N7 methyltransferase RS20_MOUSE 40S ribosomal protein S20 LYAR_MOUSE Cell growth-regulating nucleolar protein
EP
Pdk3 Nucks1 Exoc4 Tor1aip1 Lancl1 Pom121 Cox5a Agps Pds5a Svil Cul5 Atxn10 Mcts2 Snx12 Acyp2 Clint1 Arl8b Ddhd2 Mrps36 Hsd17b11 Sbf1 Ddost Kif1b Cox15 Dpysl3 Wnk1 Snrpa Dnm1 Gm2a Mapk1 Map2k2 Gstm5 Ddx39a Cst3 Ppp3ca Cwf19l1 Rab14 Spg7 Scly Mrps23 Psmc6 Gpd1l Cbr4 Golga5 Sec16a Mrpl39 Rab18 Lpp Rpl38 Abcb7 Nenf Igfbp7 Ube2k Pex3 Kpna3 Hccs Mtch1 Ogfr Phldb1 Rnmt Rps20 Lyar
AC C
sp|Q922H2|PDK3_MOUSE sp|Q80XU3|NUCKS_MOUSE sp|O35382|EXOC4_MOUSE sp|Q921T2|TOIP1_MOUSE sp|O89112|LANC1_MOUSE sp|Q8K3Z9|PO121_MOUSE sp|P12787|COX5A_MOUSE sp|Q8C0I1|ADAS_MOUSE sp|Q6A026|PDS5A_MOUSE sp|Q8K4L3|SVIL_MOUSE sp|Q9D5V5|CUL5_MOUSE sp|P28658|ATX10_MOUSE sp|Q9CQ21|MCTS2_MOUSE tr|Q3TGS7|Q3TGS7_MOUSE sp|P56375|ACYP2_MOUSE sp|Q99KN9|EPN4_MOUSE sp|Q9CQW2|ARL8B_MOUSE sp|Q80Y98|DDHD2_MOUSE sp|Q9CQX8|RT36_MOUSE sp|Q9EQ06|DHB11_MOUSE sp|Q6ZPE2|MTMR5_MOUSE sp|O54734|OST48_MOUSE sp|Q60575|KIF1B_MOUSE sp|Q8BJ03|COX15_MOUSE sp|Q62188|DPYL3_MOUSE sp|P83741|WNK1_MOUSE sp|Q62189|SNRPA_MOUSE sp|P39053|DYN1_MOUSE sp|Q60648|SAP3_MOUSE sp|P63085|MK01_MOUSE sp|Q63932|MP2K2_MOUSE sp|P48774|GSTM5_MOUSE sp|Q8VDW0|DX39A_MOUSE sp|P21460|CYTC_MOUSE sp|P63328-2|PP2BA_MOUSE sp|Q8CI33|C19L1_MOUSE sp|Q91V41|RAB14_MOUSE sp|Q3ULF4|SPG7_MOUSE sp|Q9JLI6|SCLY_MOUSE sp|Q8VE22|RT23_MOUSE sp|P62334|PRS10_MOUSE sp|Q3ULJ0|GPD1L_MOUSE sp|Q91VT4|CBR4_MOUSE sp|Q9QYE6|GOGA5_MOUSE tr|A2AIX1|A2AIX1_MOUSE sp|Q9JKF7|RM39_MOUSE sp|P35293|RAB18_MOUSE sp|Q8BFW7|LPP_MOUSE sp|Q9JJI8|RL38_MOUSE sp|Q61102|ABCB7_MOUSE sp|Q9CQ45|NENF_MOUSE sp|Q61581|IBP7_MOUSE sp|P61087|UBE2K_MOUSE sp|Q9QXY9|PEX3_MOUSE sp|O35344|IMA4_MOUSE sp|P53702|CCHL_MOUSE sp|Q791T5|MTCH1_MOUSE sp|Q99PG2|OGFR_MOUSE sp|Q6PDH0|PHLB1_MOUSE sp|Q9D0L8|MCES_MOUSE sp|P60867|RS20_MOUSE sp|Q08288|LYAR_MOUSE
206.675 501.405 362.437 397.758 427.111 301.699 380.412 264.937 291.427 311.047 437.359 342.563 349.747 312.672 629.251 528.034 512.825 581.289 291.098 464.934 340.936 332.911 341.613 532.656 401.407 486.19 351.729 403.229 380.436 308.297 291.548 429.979 274.154 374.639 319.11 209.128 468.338 402.097 437.235 663.205 318.899 366.237 360.994 223.47 260.526 465.171 357.223 233.536 516.373 419.558 472.387 393.161 649.904 306.559 198.119 308.173 473.313 462.312 392.746 522.538 364.086 462.326
373.244 80.4791 551.491 395.188 939.04 237.616 447.186 660.238 367.697 305.321 450.456 946.481 530.325 245.046 292.12 346.842 583.832 481.576 102.953 262.444 375.1 345.899 347.396 478.233 260.43 374.714 347.756 493.694 212.982 294.576 376.999 367.416 592.346 233.047 320.501 299.516 379.381 230.37 236.924 463.752 478.304 444.814 426.775 263.924 478.969 310.579 549.877 510.458 667.234 325.624 269.406 92.8478 1045.24 302.782 645.365 329.342 489.389 199.125 254.624 891.008 596.946 523.67
484.218 379.523 420.996 328.077 558.663 387.502 946.934 300.413 276.56 561.346 385.498 516.767 576.482 508.772 684.42 623.087 384.779 793.576 80.1064 279.981 457.11 282.27 411.349 460.916 308.554 672.335 637.304 413.294 449.587 266.183 471.697 376.628 330.02 425.986 273.375 321.538 395.179 282.379 419.32 607.968 552.261 483.64 723.594 367.759 608.736 517.546 432.501 1116.02 930.734 357.899 654.521 336.493 1109.34 406.181 561.466 552.982 404.931 253.227 545.824 641.94 772.255 961.905
1.29 1.27 1.27 1.27 1.25 1.25 1.24 1.23 1.23 1.23 1.21 1.20 1.20 1.20 1.18 1.18 1.18 1.18 1.17 1.17 1.16 1.16 1.16 1.15 1.15 1.15 1.15 1.14 1.13 1.13 1.12 1.11 1.11 1.11 1.10 1.10 1.10 1.09 1.09 1.08 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.05 1.05 1.05 1.04 1.03 1.03 1.03 1.03 1.02 1.02 1.02 1.02
2.28 0.72 1.72 0.98 1.68 1.07 2.13 1.90 1.31 1.53 1.11 2.82 1.78 1.24 0.92 1.08 0.98 1.08 0.32 0.64 1.32 1.01 1.04 0.91 0.73 1.15 1.42 1.08 0.90 0.86 1.51 1.04 1.70 0.77 0.90 1.45 0.85 0.68 0.75 0.77 1.45 1.29 1.53 1.18 1.95 0.84 1.44 3.54 1.47 0.84 0.98 0.50 1.74 1.21 2.78 1.37 1.10 0.44 0.95 1.19 2.04 1.64
ACCEPTED MANUSCRIPT
271.138 292.768 321.893 487.293 510.103 481.796 373.109 296.184 382.748 590.949 387.005 483.874 312.606 305.843 355.894 517.245 434.522 348.237 201.835 419.381 282.593 356.287 483.792 220.291 614.942 377.133 378.764 283.486 446.357 318.516 371.444 499.861 456.252 299.195 532.534 490.458 411.698 494.601 292.015 575.343 285.07 340.508 401.628 476.179 401.179 379.071 317.598 483.988 689.742 276.954 522.214 546.096 235.332 564.733 281.843 501.408 572.637 537.847 597.146 623.613 366.092 488.641
290.746 305.038 336.756 592.719 546.641 587.194 360.723 316.963 402.07 620.356 383.682 337.922 357.874 300.058 351.394 514.466 521.802 437.799 237.247 435.927 312.311 439.894 354.416 202.915 714.274 417.239 398.089 266.025 420.329 294.162 411.824 523.285 442.201 294.748 617.823 420.299 423.789 485.073 310.51 537.265 268.93 298.444 307.408 446.523 370.103 365.866 299.639 419.84 691.288 294.866 487.8 511.882 259.479 534.712 201.133 427.467 492.665 463.372 487.351 487.755 350.002 402.835
RI PT
311.718 285.365 317.617 538.827 583.259 531.458 320.366 306.198 359.303 699.956 365.718 324.913 367.347 343.985 408.264 475.835 525.361 420.256 251.575 455.443 332.573 498.737 424.042 238.465 709.351 425.097 431.592 257.745 389.857 271.857 396.51 459.357 422.149 303.074 649.516 428.378 448.786 490.897 326.797 501.514 300.965 378.765 275.327 513.588 418.502 366.73 307.973 433.089 663.167 350.873 490.014 542.328 331.637 540.666 259.958 486.112 767.855 498.057 592.032 489.079 480.198 546.401
SC
8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
M AN U
TE D
Pspc1 Ranbp3 Scrn3 Prkar2a Snx3 Wdr61 Vps26a Zc3h11a Ube2v1 Col4a3bp Chchd6 Hnrnpf Ccs Prkcdbp Rreb1 Ubxn7 Acyp1 Lpin1 Trip10 Rpl36 Rprd1a Hexb Dag1 Psma3 Pxn Ogdhl Tpp1
TRXR1_MOUSE Thioredoxin reductase 1, cytoplasmic DAZP1_MOUSE DAZ-associated protein 1 5NT3A_MOUSE Cytosolic 5'-nucleotidase 3A THUM1_MOUSE THUMP domain-containing protein 1 DC1L2_MOUSE Cytoplasmic dynein 1 light intermediate chain 2 IF4E_MOUSE Eukaryotic translation initiation factor 4E VASP_MOUSE Vasodilator-stimulated phosphoprotein AGFG1_MOUSE Arf-GAP domain and FG repeat-containing protein 1 DCP1A_MOUSE mRNA-decapping enzyme 1A SSRP1_MOUSE FACT complex subunit SSRP1 RL31_MOUSE 60S ribosomal protein L31 LIPL_MOUSE Lipoprotein lipase SETD3_MOUSE Histone-lysine N-methyltransferase setd3 ACAD8_MOUSE Isobutyryl-CoA dehydrogenase, mitochondrial UBA5_MOUSE Ubiquitin-like modifier-activating enzyme 5 S10AD_MOUSE Protein S100-A13 VAT1_MOUSE Synaptic vesicle membrane protein VAT-1 homolog WDR12_MOUSE Ribosome biogenesis protein WDR12 D2HDH_MOUSE D-2-hydroxyglutarate dehydrogenase, mitochondrial TFB1M_MOUSE Dimethyladenosine transferase 1, mitochondrial FLOT1_MOUSE Flotillin-1 RUVB2_MOUSE RuvB-like 2 AP1M1_MOUSE AP-1 complex subunit mu-1 AP1G1_MOUSE AP-1 complex subunit gamma-1 PAK3_MOUSE Serine/threonine-protein kinase PAK 3 CHRD1_MOUSE Cysteine and histidine-rich domain-containing protein 1 CSTF3_MOUSE Cleavage stimulation factor subunit 3 UB2G2_MOUSE Ubiquitin-conjugating enzyme E2 G2 RBBP4_MOUSE Histone-binding protein RBBP4 PACN2_MOUSE Protein kinase C and casein kinase substrate in neurons protein 2 CBX1_MOUSE Chromobox protein homolog 1 Q544X6_MOUSE Ferrochelatase WBP11_MOUSE WW domain-binding protein 11 MAP2_MOUSE Methionine aminopeptidase 2 CF211_MOUSE UPF0364 protein C6orf211 homolog PSPC1_MOUSE Paraspeckle component 1 RANB3_MOUSE Ran-binding protein 3 SCRN3_MOUSE Secernin-3 Q8K1M3_MOUSE Protein kinase, cAMP dependent regulatory, type II alpha Q78ZM0_MOUSE Sorting nexin 3 WDR61_MOUSE WD repeat-containing protein 61 VP26A_MOUSE Vacuolar protein sorting-associated protein 26A ZC11A_MOUSE Zinc finger CCCH domain-containing protein 11A UB2V1_MOUSE Ubiquitin-conjugating enzyme E2 variant 1 C43BP_MOUSE Collagen type IV alpha-3-binding protein CHCH6_MOUSE Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial HNRPF_MOUSE Heterogeneous nuclear ribonucleoprotein F CCS_MOUSE Copper chaperone for superoxide dismutase PRDBP_MOUSE Protein kinase C delta-binding protein RREB1_MOUSE Ras-responsive element-binding protein 1 G5E8R8_MOUSE MCG129950, isoform CRA_a ACYP1_MOUSE Acylphosphatase-1 LPIN1_MOUSE Phosphatidate phosphatase LPIN1 CIP4_MOUSE Isoform 3 of Cdc42-interacting protein 4 Q6ZWZ4_MOUSE 60S ribosomal protein L36 RPR1A_MOUSE Regulation of nuclear pre-mRNA domain-containing protein 1A HEXB_MOUSE Beta-hexosaminidase subunit beta DAG1_MOUSE Dystroglycan PSA3_MOUSE Proteasome subunit alpha type-3 PAXI_MOUSE Paxillin E9Q7L0_MOUSE Protein Ogdhl TPP1_MOUSE Tripeptidyl-peptidase 1
EP
Txnrd1 Dazap1 Nt5c3a Thumpd1 Dync1li2 Eif4e Vasp Agfg1 Dcp1a Ssrp1 Rpl31 Lpl Setd3 Acad8 Uba5 S100a13 Vat1 Wdr12 D2hgdh Tfb1m Flot1 Ruvbl2 Ap1m1 Ap1g1 Pak3 Chordc1 Cstf3 Ube2g2 Rbbp4 Pacsin2 Cbx1 Fech Wbp11 Metap2
AC C
sp|Q9JMH6|TRXR1_MOUSE sp|Q9JII5|DAZP1_MOUSE sp|Q9D020|5NT3A_MOUSE sp|Q99J36|THUM1_MOUSE sp|Q6PDL0|DC1L2_MOUSE sp|P63073|IF4E_MOUSE sp|P70460|VASP_MOUSE sp|Q8K2K6|AGFG1_MOUSE sp|Q91YD3|DCP1A_MOUSE sp|Q08943|SSRP1_MOUSE sp|P62900|RL31_MOUSE sp|P11152|LIPL_MOUSE sp|Q91WC0|SETD3_MOUSE sp|Q9D7B6|ACAD8_MOUSE sp|Q8VE47|UBA5_MOUSE sp|P97352|S10AD_MOUSE sp|Q62465|VAT1_MOUSE sp|Q9JJA4|WDR12_MOUSE sp|Q8CIM3|D2HDH_MOUSE sp|Q8JZM0|TFB1M_MOUSE sp|O08917|FLOT1_MOUSE sp|Q9WTM5|RUVB2_MOUSE sp|P35585|AP1M1_MOUSE sp|P22892|AP1G1_MOUSE sp|Q61036|PAK3_MOUSE sp|Q9D1P4|CHRD1_MOUSE sp|Q99LI7|CSTF3_MOUSE sp|P60605|UB2G2_MOUSE sp|Q60972|RBBP4_MOUSE sp|Q9WVE8|PACN2_MOUSE sp|P83917|CBX1_MOUSE tr|Q544X6|Q544X6_MOUSE sp|Q923D5|WBP11_MOUSE sp|O08663|MAP2_MOUSE sp|A6H630|CF211_MOUSE sp|Q8R326|PSPC1_MOUSE sp|Q9CT10|RANB3_MOUSE sp|Q3TMH2|SCRN3_MOUSE tr|Q8K1M3|Q8K1M3_MOUSE tr|Q78ZM0|Q78ZM0_MOUSE sp|Q9ERF3|WDR61_MOUSE sp|P40336|VP26A_MOUSE sp|Q6NZF1|ZC11A_MOUSE sp|Q9CZY3|UB2V1_MOUSE sp|Q9EQG9|C43BP_MOUSE sp|Q91VN4|CHCH6_MOUSE sp|Q9Z2X1|HNRPF_MOUSE sp|Q9WU84|CCS_MOUSE sp|Q91VJ2|PRDBP_MOUSE sp|Q3UH06|RREB1_MOUSE tr|G5E8R8|G5E8R8_MOUSE sp|P56376|ACYP1_MOUSE sp|Q91ZP3|LPIN1_MOUSE sp|Q8CJ53-3|CIP4_MOUSE tr|Q6ZWZ4|Q6ZWZ4_MOUSE sp|Q8VDS4|RPR1A_MOUSE sp|P20060|HEXB_MOUSE sp|Q62165|DAG1_MOUSE sp|O70435|PSA3_MOUSE sp|Q8VI36|PAXI_MOUSE tr|E9Q7L0|E9Q7L0_MOUSE sp|O89023|TPP1_MOUSE
296.341 276.145 304.973 435.79 547.862 426.952 332.427 284.596 338.507 658.614 359.966 460.902 313.197 337.231 397.841 455.209 412.546 310.226 203.89 411.826 283.24 384.725 518.653 236.843 552.71 349.118 371.661 247.981 373.814 265.343 315.712 381.217 385.531 269.886 487.507 432.863 372.629 427.005 262.11 452.998 265.745 352.459 303.298 444.298 366.044 303.686 248.409 381.155 487.523 250.57 387.345 425.72 227.522 414.46 255.925 398.395 627.998 390.644 490.736 413.367 273.501 345.406
621.143 628.806 505.616 575.557 470.68 542.925 572.903 293.685 366.884 271.498 290.227 386.503 211.513 292.005 384.296 365.18 582.83 390.192 202.195 208.672 361.108 473.297 423.078 595.24 507.65 603.949 394.589 223.101 314.947 469.98 216.5 247.492 256.12 327.725 537.084 551.583 551.817 628.84 314.163 354.241 296.874 302.915 412.989 368.763 333.975 422.136 588.583 602.576 418.821 263.179 393.373 342.699 114.877 713.359 286.949 388.373 545.709 349.366 541.839 525.725 393.754 224.762
504.346 1113.31 520.356 911.762 548.892 780.311 786.343 380.758 452.008 213.065 607.562 764.226 236.949 426.801 302.602 988.452 434.744 363.328 314.565 292.416 360.213 336.396 420.667 508.985 740.765 609.556 306.672 554.572 566.685 667.562 320.914 598.648 437.886 781.036 478.364 712.906 614.035 960.893 374.816 817.092 345.723 256.12 869.103 640.899 563.152 868.206 945.966 968.472 789.035 465.511 533.136 642.58 209.836 780.499 671.712 465.449 327.451 573.74 533.499 1045.59 396.283 387.168
1.01 1.01 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.95 0.94 0.94 0.94 0.94 0.93 0.93 0.93 0.93 0.92 0.91 0.90 0.90 0.90 0.90 0.90 0.88 0.87 0.87 0.87 0.86 0.86 0.86 0.86 0.84 0.84 0.84 0.82 0.82 0.81 0.74 0.72
1.93 3.01 1.60 1.45 0.93 1.31 1.96 1.12 1.10 0.38 1.19 1.42 0.66 1.11 0.90 1.36 1.06 0.98 1.14 0.57 1.17 0.95 0.93 2.41 0.94 1.51 0.87 1.44 1.05 1.93 0.70 0.88 0.79 1.84 0.86 1.38 1.35 1.61 1.11 1.09 1.10 0.78 1.89 1.02 1.09 1.73 2.45 1.71 0.89 1.16 0.92 0.91 0.57 1.35 1.77 0.86 0.65 0.89 0.90 1.41 0.93 0.59
ACCEPTED MANUSCRIPT
TE D
380.577 644.727 532.158 348.252 1243.08 253.137 220.279 274.048 255.956 316.023 361.058 294.672 262.308 317.312 224.385 260.636 200.694 223.211 193.222 221.112 282.693 198.094 180.889 281.233 185.601 343.622 274.499 380.661 264.514 254.169 393.603 234.551 418.369 292.209 363.427 295.988 468.564 204.87 294.925 360.735 478.244 533.273 432.381 250.93 238.582 167.143 186.311 225.895 410.608 273.825 293.815 365.688 413.332 434.654 375.339 259.545 261.512 282.813 233.472 521.345 286.679 262.359
318.843 469.846 246.772 479.746 1612.74 382.5 363.588 482.267 441.022 492.416 699.247 452.596 338.772 524.285 402.845 495.23 414.437 352.815 269.823 322.154 466.591 346.474 236.191 476.33 296.353 487.574 437.025 556.404 387.539 328.176 561.115 363.993 618.834 375.556 589.448 465.04 455.592 265.512 415.764 457.255 556.672 676.13 512.756 330.066 391.716 268.71 271.919 297.257 363.984 353.067 283.443 525.509 509.958 532.909 548.409 375.219 331.218 417.114 264.598 595.06 269.136 335.378
RI PT
482.931 700.728 306.942 319.571 799.791 218.552 234.241 272.049 284.263 340.206 474.189 320.316 255.783 359.27 267.089 329.171 312.671 276.739 205.544 257.095 342.836 243.093 221.224 357.256 234.124 357.862 337.677 382.337 330.458 252.434 462.108 306.137 456.353 309.764 416.95 382.238 438.008 208.636 322.961 402.206 430.47 568.458 490.323 280.892 365.892 246.229 233.385 233.591 254.284 318.98 293.967 440.206 455.918 422.757 442.704 327.193 319.728 365.365 221.995 506.958 285.815 292.103
SC
8 8 8 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
M AN U
GALM_MOUSE Aldose 1-epimerase ADRO_MOUSE NADPH:adrenodoxin oxidoreductase, mitochondrial FSCN1_MOUSE Fascin GNPAT_MOUSE Dihydroxyacetone phosphate acyltransferase BAP29_MOUSE B-cell receptor-associated protein 29 RDH13_MOUSE Retinol dehydrogenase 13 RT29_MOUSE 28S ribosomal protein S29, mitochondrial FA98A_MOUSE Protein FAM98A TMX2_MOUSE Thioredoxin-related transmembrane protein 2 RT25_MOUSE 28S ribosomal protein S25, mitochondrial XRCC6_MOUSE X-ray repair cross-complementing protein 6 CD47_MOUSE Leukocyte surface antigen CD47 CHM2A_MOUSE Charged multivesicular body protein 2a DHX29_MOUSE ATP-dependent RNA helicase Dhx29 ZW10_MOUSE Centromere/kinetochore protein zw10 homolog ADCK3_MOUSE Chaperone activity of bc1 complex-like, mitochondrial TOM40_MOUSE Mitochondrial import receptor subunit TOM40 homolog NOP58_MOUSE Nucleolar protein 58 FAK1_MOUSE Focal adhesion kinase 1 F7C846_MOUSE Metaxin-1 MTM1_MOUSE Myotubularin ERLN1_MOUSE Erlin-1 ADPGK_MOUSE ADP-dependent glucokinase MSH2_MOUSE DNA mismatch repair protein Msh2 APEX1_MOUSE DNA-(apurinic or apyrimidinic site) lyase KCC2G_MOUSE Isoform 3 of Calcium/calmodulin-dependent protein kinase type II subunit gamma RPB1_MOUSE DNA-directed RNA polymerase II subunit RPB1 K1468_MOUSE LisH domain and HEAT repeat-containing protein KIAA1468 NUDC1_MOUSE NudC domain-containing protein 1 MRCKB_MOUSE Serine/threonine-protein kinase MRCK beta KPBB_MOUSE Phosphorylase b kinase regulatory subunit beta MTCH2_MOUSE Mitochondrial carrier homolog 2 V9GX06_MOUSE Uncharacterized protein (Fragment) RS27_MOUSE 40S ribosomal protein S27 TMED4_MOUSE Transmembrane emp24 domain-containing protein 4 GT251_MOUSE Procollagen galactosyltransferase 1 FUND2_MOUSE FUN14 domain-containing protein 2 DEN4C_MOUSE DENN domain-containing protein 4C Q91Z50_MOUSE Flap endonuclease 1 B9EJ54_MOUSE MCG21756, isoform CRA_b LTN1_MOUSE E3 ubiquitin-protein ligase listerin TRI25_MOUSE E3 ubiquitin/ISG15 ligase TRIM25 PTCD3_MOUSE Pentatricopeptide repeat domain-containing protein 3, mitochondrial ITAV_MOUSE Integrin alpha-V RT09_MOUSE 28S ribosomal protein S9, mitochondrial DDX46_MOUSE Probable ATP-dependent RNA helicase DDX46 OCTC_MOUSE Peroxisomal carnitine O-octanoyltransferase UK114_MOUSE Ribonuclease UK114 H3C_MOUSE Histone H3.3C ACSF3_MOUSE Acyl-CoA synthetase family member 3, mitochondrial PLCB_MOUSE 1-acyl-sn-glycerol-3-phosphate acyltransferase beta FKB15_MOUSE FK506-binding protein 15 SERHL_MOUSE Serine hydrolase-like protein COG5_MOUSE Conserved oligomeric Golgi complex subunit 5 VAC14_MOUSE Protein VAC14 homolog PRP6_MOUSE Pre-mRNA-processing factor 6 TBL2_MOUSE Transducin beta-like protein 2 GUF1_MOUSE Translation factor Guf1, mitochondrial AP2M1_MOUSE AP-2 complex subunit mu DOC11_MOUSE Dedicator of cytokinesis protein 11 RL19_MOUSE 60S ribosomal protein L19 NHLC2_MOUSE NHL repeat-containing protein 2
EP
Galm Fdxr Fscn1 Gnpat Bcap29 Rdh13 Dap3 Fam98a Tmx2 Mrps25 Xrcc6 Cd47 Chmp2a Dhx29 Zw10 Adck3 Tomm40 Nop58 Ptk2 Mtx1 Mtm1 Erlin1 Adpgk Msh2 Apex1 Camk2g Polr2a Kiaa1468 Nudcd1 Cdc42bpb Phkb Mtch2 Gm11214 Rps27 Tmed4 Colgalt1 Fundc2 Dennd4c Fen1 Nup205 Ltn1 Trim25 Ptcd3 Itgav Mrps9 Ddx46 Crot Hrsp12 H3f3c Acsf3 Agpat2 Fkbp15 Serhl Cog5 Vac14 Prpf6 Tbl2 Guf1 Ap2m1 Dock11 Rpl19 Nhlrc2
AC C
sp|Q8K157|GALM_MOUSE sp|Q61578|ADRO_MOUSE sp|Q61553|FSCN1_MOUSE sp|P98192|GNPAT_MOUSE sp|Q61334|BAP29_MOUSE sp|Q8CEE7|RDH13_MOUSE sp|Q9ER88|RT29_MOUSE sp|Q3TJZ6|FA98A_MOUSE sp|Q9D710|TMX2_MOUSE sp|Q9D125|RT25_MOUSE sp|P23475|XRCC6_MOUSE sp|Q61735|CD47_MOUSE sp|Q9DB34|CHM2A_MOUSE sp|Q6PGC1|DHX29_MOUSE sp|O54692|ZW10_MOUSE sp|Q60936|ADCK3_MOUSE sp|Q9QYA2|TOM40_MOUSE sp|Q6DFW4|NOP58_MOUSE sp|P34152|FAK1_MOUSE tr|F7C846|F7C846_MOUSE sp|Q9Z2C5|MTM1_MOUSE sp|Q91X78|ERLN1_MOUSE sp|Q8VDL4|ADPGK_MOUSE sp|P43247|MSH2_MOUSE sp|P28352|APEX1_MOUSE sp|Q923T9-3|KCC2G_MOUSE sp|P08775|RPB1_MOUSE sp|Q148V7|K1468_MOUSE sp|Q6PIP5|NUDC1_MOUSE sp|Q7TT50|MRCKB_MOUSE sp|Q7TSH2|KPBB_MOUSE sp|Q791V5|MTCH2_MOUSE tr|V9GX06|V9GX06_MOUSE sp|Q6ZWU9|RS27_MOUSE sp|Q8R1V4|TMED4_MOUSE sp|Q8K297|GT251_MOUSE sp|Q9D6K8|FUND2_MOUSE sp|A6H8H2|DEN4C_MOUSE tr|Q91Z50|Q91Z50_MOUSE tr|B9EJ54|B9EJ54_MOUSE sp|Q6A009|LTN1_MOUSE sp|Q61510|TRI25_MOUSE sp|Q14C51|PTCD3_MOUSE sp|P43406|ITAV_MOUSE sp|Q9D7N3|RT09_MOUSE sp|Q569Z5|DDX46_MOUSE sp|Q9DC50|OCTC_MOUSE sp|P52760|UK114_MOUSE sp|P02301|H3C_MOUSE sp|Q3URE1|ACSF3_MOUSE sp|Q8K3K7|PLCB_MOUSE sp|Q6P9Q6|FKB15_MOUSE sp|Q9EPB5|SERHL_MOUSE sp|Q8C0L8|COG5_MOUSE sp|Q80WQ2|VAC14_MOUSE sp|Q91YR7|PRP6_MOUSE sp|Q9R099|TBL2_MOUSE sp|Q8C3X4|GUF1_MOUSE sp|P84091|AP2M1_MOUSE sp|A2AF47|DOC11_MOUSE sp|P84099|RL19_MOUSE sp|Q8BZW8|NHLC2_MOUSE
303.784 449.378 199.866 690.898 1809.88 331.563 316.481 326.174 345.712 447.087 495.997 405.245 379.046 412.29 273.822 300.63 260.941 304.205 251.188 300.195 342.117 222.677 281.52 344.105 235.078 399.306 335.7 400.093 350.567 298.306 493.506 301.95 437.139 350.225 343.681 342.978 623.089 224.488 314.565 444.496 517.263 625.349 570.696 294.3 315.157 213.908 217.351 237.81 404.55 331.373 393.511 402.046 488.056 449.684 383.4 292.479 329.122 314.353 245.968 555.911 370.953 284.495
367.785 608.869 675.274 470.411 1543.18 277.805 361.046 627.305 240.872 223.859 417.019 610.102 318.153 355.757 339.395 282.833 984.956 766.331 277.454 272.575 365.323 422.688 261.089 367.099 461.295 542.282 429.372 464.494 495.394 461.19 389.924 385.792 867.788 369.176 343.383 240.145 450.856 376.87 582.24 517.548 539.147 422.894 207.384 311.201 146.849 307.405 354.15 167.111 561.804 165.818 194.863 340.034 542.29 469.843 388.19 427.713 308.196 205.756 277.941 267.29 407.447 256.19
557.656 741.109 329.767 315.623 1106.57 268.951 593.96 481.146 172.394 297.099 466.089 342.201 234.467 313.624 309.561 579.399 290.828 366.386 385.342 154.655 222.592 175.132 182.752 282.919 230.975 735.38 331.016 498.288 319.431 338.929 418.422 230.669 662.159 265.232 262.774 200.657 454.242 353.862 528.375 314.528 575.052 543.008 351.521 230.289 234.175 284.121 170.572 307.644 354.047 249.436 230.466 437.324 559.908 305.302 385.611 275.326 237.867 236.763 230.912 324.818 644.266 240.697
0.72 0.68 0.53 1.75 1.68 1.51 1.50 1.48 1.46 1.43 1.43 1.39 1.39 1.38 1.38 1.35 1.32 1.31 1.31 1.30 1.29 1.29 1.29 1.28 1.27 1.26 1.26 1.25 1.24 1.24 1.23 1.23 1.21 1.21 1.20 1.19 1.19 1.18 1.18 1.18 1.18 1.18 1.17 1.17 1.17 1.17 1.17 1.16 1.16 1.15 1.15 1.15 1.15 1.15 1.14 1.14 1.14 1.13 1.12 1.12 1.12 1.12
1.07 1.00 1.20 1.18 1.30 1.16 2.10 2.03 0.76 0.79 1.06 1.55 1.07 0.99 1.32 1.46 2.49 2.27 1.66 0.89 0.94 1.36 1.10 1.02 1.65 1.82 1.24 1.26 1.37 1.58 0.94 1.14 1.75 1.05 0.78 0.65 1.00 1.77 1.80 1.09 1.23 0.88 0.61 1.02 0.63 1.43 1.25 1.03 1.38 0.70 0.72 0.96 1.27 0.90 0.95 1.20 0.94 0.68 1.12 0.58 1.84 0.90
ACCEPTED MANUSCRIPT
286.792 330.424 300.101 170.135 383.073 438.824 352.467 299.226 378.074 380.105 304.607 431.244 263.132 392.994 364.063 329.998 284.917 636.62 356.693 402.71 220.766 315.292 292.62 191.218 465.953 307.002 328.644 341.529 376.493 364.887 403.901 284.607 326.483 269.767 292.023 194.894 384.211 528.185 233.454 320.873 444.378 354.978 330.768 290.095 354.657 218.092 203.986 393.973 345.954 311.954 288.29 396.273 523.26 302.171 356.738 518.271 469.665 324.939 324.159 320.616 551.163 338.955
347.355 421.846 363.772 225.91 526.721 595.23 390.439 396.662 510.312 410.608 371.016 489.887 349.699 285.769 390.021 397.039 373.948 702.302 510.742 467.949 261.353 393.509 354.67 235.63 533.584 383.943 395.62 458.98 423.036 408.35 557.768 363.64 412.63 353.968 313.17 264.147 401.244 282.354 269.582 320.413 383.306 314.924 355.07 257.684 459.765 238.002 229.058 349.391 374.407 315.119 321.102 466.889 548.612 332.26 463.136 521.61 592.774 339.839 320.377 353.406 500.173 393.929
RI PT
258.841 359.179 322.783 179.291 451.234 520.253 311.936 349.499 459.673 368.435 323.148 379.111 294.443 286.97 342.378 351.328 332.578 722.25 445.026 451.54 235.919 362.81 303.836 236.231 483.002 365.995 393.974 446.715 381.765 336.976 485.372 346.423 369.517 362.502 301.94 238.513 343.467 266.09 281.536 324.494 331.928 283.211 320.378 262.683 486.829 217.479 221.982 311.973 358.49 323.222 266.763 509.381 496.797 356.674 440.932 457.147 636.681 337.782 288.77 313.677 572.527 378.602
SC
7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
M AN U
TE D
MIA40_MOUSE Mitochondrial intermembrane space import and assembly protein 40 NOP2_MOUSE Putative ribosomal RNA methyltransferase NOP2 MPP6_MOUSE MAGUK p55 subfamily member 6 PPM1B_MOUSE Protein phosphatase 1B GLCM_MOUSE Glucosylceramidase CRTAP_MOUSE Cartilage-associated protein PDCD5_MOUSE Programmed cell death protein 5 VPS25_MOUSE Vacuolar protein-sorting-associated protein 25 E9Q4K7_MOUSE Protein Kif13b NDUS5_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NCBP1_MOUSE Nuclear cap-binding protein subunit 1 UBQL2_MOUSE Ubiquilin-2 DYSF_MOUSE Dysferlin ARP10_MOUSE Actin-related protein 10 PNPO_MOUSE Pyridoxine-5'-phosphate oxidase KIF3B_MOUSE Kinesin-like protein KIF3B CELF2_MOUSE CUGBP Elav-like family member 2 RM03_MOUSE 39S ribosomal protein L3, mitochondrial ROCK1_MOUSE Rho-associated protein kinase 1 TPC11_MOUSE Trafficking protein particle complex subunit 11 ANKY2_MOUSE Ankyrin repeat and MYND domain-containing protein 2 SYCM_MOUSE Probable cysteine--tRNA ligase, mitochondrial SUMF2_MOUSE Sulfatase-modifying factor 2 RAB2A_MOUSE Ras-related protein Rab-2A EMC8_MOUSE ER membrane protein complex subunit 8 UMPS_MOUSE Uridine 5'-monophosphate synthase TIM50_MOUSE Mitochondrial import inner membrane translocase subunit TIM50 PARN_MOUSE Poly(A)-specific ribonuclease PARN ISCA1_MOUSE Iron-sulfur cluster assembly 1 homolog, mitochondrial RMP_MOUSE Unconventional prefoldin RPB5 interactor ACO13_MOUSE Acyl-coenzyme A thioesterase 13 D3Z0M9_MOUSE MCG18410, isoform CRA_a AP3S1_MOUSE AP-3 complex subunit sigma-1 GNPI2_MOUSE Glucosamine-6-phosphate isomerase 2 PEX14_MOUSE Peroxisomal membrane protein PEX14 PPR21_MOUSE Protein phosphatase 1 regulatory subunit 21 E9PX68_MOUSE Protein Slc4a1ap HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthase, cytoplasmic HDAC1_MOUSE Histone deacetylase 1 BROX_MOUSE BRO1 domain-containing protein BROX A1AG1_MOUSE Alpha-1-acid glycoprotein 1 CHM4B_MOUSE Charged multivesicular body protein 4b MD1L1_MOUSE Mitotic spindle assembly checkpoint protein MAD1 SMRC1_MOUSE SWI/SNF complex subunit SMARCC1 SIK2_MOUSE Serine/threonine-protein kinase SIK2 MIRO2_MOUSE Mitochondrial Rho GTPase 2 NIPA_MOUSE Nuclear-interacting partner of ALK PFD6_MOUSE Prefoldin subunit 6 PAPOA_MOUSE Poly(A) polymerase alpha CUL2_MOUSE Cullin-2 RABE1_MOUSE Rab GTPase-binding effector protein 1 RALY_MOUSE RNA-binding protein Raly SPF27_MOUSE Pre-mRNA-splicing factor SPF27 SAE1_MOUSE SUMO-activating enzyme subunit 1 NICA_MOUSE Nicastrin KLC1_MOUSE Kinesin light chain 1 SNR40_MOUSE U5 small nuclear ribonucleoprotein 40 kDa protein MYG1_MOUSE UPF0160 protein MYG1, mitochondrial SRRM1_MOUSE Serine/arginine repetitive matrix protein 1 F192A_MOUSE Protein FAM192A PDLI5_MOUSE PDZ and LIM domain protein 5 PRPF3_MOUSE U4/U6 small nuclear ribonucleoprotein Prp3
EP
Chchd4 Nop2 Mpp6 Ppm1b Gba Crtap Pdcd5 Vps25 Kif13b Ndufs5 Ncbp1 Ubqln2 Dysf Actr10 Pnpo Kif3b Celf2 Mrpl3 Rock1 Trappc11 Ankmy2 Cars2 Sumf2 Rab2a Emc8 Umps Timm50 Parn Isca1 Uri1 Acot13 Ddx23 Ap3s1 Gnpda2 Pex14 Ppp1r21 Slc4a1ap Hmgcs1 Hdac1 Brox Orm1 Chmp4b Mad1l1 Smarcc1 Sik2 Rhot2 Zc3hc1 Pfdn6 Papola Cul2 Rabep1 Raly Bcas2 Sae1 Ncstn Klc1 Snrnp40 Myg1 Srrm1 Fam192a Pdlim5 Prpf3
AC C
sp|Q8VEA4|MIA40_MOUSE sp|Q922K7|NOP2_MOUSE sp|Q9JLB0|MPP6_MOUSE sp|P36993|PPM1B_MOUSE sp|P17439|GLCM_MOUSE sp|Q9CYD3|CRTAP_MOUSE sp|P56812|PDCD5_MOUSE sp|Q9CQ80|VPS25_MOUSE tr|E9Q4K7|E9Q4K7_MOUSE sp|Q99LY9|NDUS5_MOUSE sp|Q3UYV9|NCBP1_MOUSE sp|Q9QZM0|UBQL2_MOUSE sp|Q9ESD7|DYSF_MOUSE sp|Q9QZB7|ARP10_MOUSE sp|Q91XF0|PNPO_MOUSE sp|Q61771|KIF3B_MOUSE sp|Q9Z0H4|CELF2_MOUSE sp|Q99N95|RM03_MOUSE sp|P70335|ROCK1_MOUSE sp|B2RXC1|TPC11_MOUSE sp|Q3TPE9|ANKY2_MOUSE sp|Q8BYM8|SYCM_MOUSE sp|Q8BPG6|SUMF2_MOUSE sp|P53994|RAB2A_MOUSE sp|O70378|EMC8_MOUSE sp|P13439|UMPS_MOUSE sp|Q9D880|TIM50_MOUSE sp|Q8VDG3|PARN_MOUSE sp|Q9D924|ISCA1_MOUSE sp|Q3TLD5|RMP_MOUSE sp|Q9CQR4|ACO13_MOUSE tr|D3Z0M9|D3Z0M9_MOUSE sp|Q9DCR2|AP3S1_MOUSE sp|Q9CRC9|GNPI2_MOUSE sp|Q9R0A0|PEX14_MOUSE sp|Q3TDD9|PPR21_MOUSE tr|E9PX68|E9PX68_MOUSE sp|Q8JZK9|HMCS1_MOUSE sp|O09106|HDAC1_MOUSE sp|Q8K2Q7|BROX_MOUSE sp|Q60590|A1AG1_MOUSE sp|Q9D8B3|CHM4B_MOUSE sp|Q9WTX8|MD1L1_MOUSE sp|P97496|SMRC1_MOUSE sp|Q8CFH6|SIK2_MOUSE sp|Q8JZN7|MIRO2_MOUSE sp|Q80YV2|NIPA_MOUSE sp|Q03958|PFD6_MOUSE sp|Q61183|PAPOA_MOUSE sp|Q9D4H8|CUL2_MOUSE sp|O35551|RABE1_MOUSE sp|Q64012|RALY_MOUSE sp|Q9D287|SPF27_MOUSE sp|Q9R1T2|SAE1_MOUSE sp|P57716|NICA_MOUSE sp|O88447|KLC1_MOUSE sp|Q6PE01|SNR40_MOUSE sp|Q9JK81|MYG1_MOUSE sp|Q52KI8|SRRM1_MOUSE sp|Q91WE2|F192A_MOUSE sp|Q8CI51|PDLI5_MOUSE sp|Q922U1|PRPF3_MOUSE
262.278 345.805 328.722 162.543 394.423 458.679 337.558 312.802 398.191 399.027 306.423 379.69 248.335 441.376 362.408 328.45 282.787 734.03 336.657 432.561 218.443 318.89 270.484 211.128 458.031 316.773 356.387 359.779 360.161 316.529 359.585 287.213 305.159 296.241 296.509 180.047 344.269 530.758 257.252 339.755 408.111 334.589 306.75 303.483 394.353 204.073 201.238 363.408 335.085 321.169 233.257 430.666 461.402 319.592 323.467 440.139 485.824 302.752 273.606 259.183 579.305 294.973
227.285 403.259 654.487 183.53 520.24 384.171 280.893 306.197 366.281 301.386 273.462 381.518 662.703 799.287 248.312 353.52 144.187 282.077 354.445 391.162 257.418 228.99 130.885 250.721 398.572 407.515 281.12 524.041 406.856 455.641 271.628 450.61 226.118 298.096 304.424 196.495 199.518 198.553 228.13 461.553 74.6766 269.561 467.3 573.685 158.061 248.853 278.346 321.928 287.057 416.512 349.668 127.762 461.134 470.508 302.77 476.053 593.298 176.89 254.33 143.121 563.594 361.396
533.133 306.948 702.514 321.018 386.588 282.401 560.937 293.202 391.893 604.08 315.869 1219 301.861 536.341 466.207 343.376 377.095 629.159 307.518 303.475 249.903 236.38 312.61 209.658 789.788 371.461 368.353 411.865 603.499 877.326 649.364 459.133 235.232 276.824 266.772 229.52 444.86 337.807 210.287 441.855 223.546 588.495 406.043 842.207 339.921 244.636 421.38 689.677 307.38 316.785 612.686 423.682 970.35 524.822 223.711 583.147 727.358 370.308 362.777 328.897 919.906 477.859
1.12 1.11 1.11 1.11 1.10 1.10 1.10 1.09 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.00 1.00 0.99 0.99 0.99 0.99 0.99 0.97 0.97 0.97 0.97 0.96 0.96
1.39 1.03 2.18 1.44 1.09 0.70 1.27 0.92 0.91 1.21 0.94 1.98 1.73 1.96 1.01 1.02 0.84 0.67 0.83 0.81 1.11 0.69 0.74 1.08 1.25 1.16 0.90 1.19 1.33 1.90 1.04 1.44 0.66 0.91 0.96 0.98 0.89 0.68 0.85 1.40 0.38 1.34 1.34 2.56 0.59 1.13 1.64 1.43 0.84 1.15 1.73 0.61 1.40 1.51 0.66 1.09 1.19 0.83 1.01 0.74 1.32 1.17
ACCEPTED MANUSCRIPT
561.669 335.547 369.486 536.275 247.566 390.203 249.793 281.82 312.003 351.909 559.58 457.915 517.567 390.475 227.74 331.135 440.378 391.98 329.021 542.403 242.943 274.411 516.874 194.013 377.698 350.919 287.338 318.455 358.429 258.365 434.01 493.534 248.479 488.15 580.938 285.975 358.151 248.782 353.569 387.845 503.72 271.447 389.276 586.74 290.647 404.85 437.016 294.727 341.339 372.721 427.716 340.887 365.499 412.162 392.216 423.446 330.027 291.713 221.743 3.26735 159.865 299.808
486.439 429.732 320.773 543.679 252.293 350.193 234.966 301.499 455.425 173.373 515.326 462.951 641.256 367.618 214.283 356.602 512.344 369.331 350.777 499.669 249.532 230.943 474.094 196.62 369.22 304.047 262.488 335.123 343.618 278.461 380.022 424.769 213.404 387.861 503.104 269.908 332.946 213.961 382.861 358.945 380.245 289.779 369.608 477.82 226.79 370.858 406.455 274.061 277.22 388.78 369.628 317.358 321.662 343.435 316.552 396.897 318.228 243.255 192.829 6.26539 351.607 542.304
RI PT
578.602 458.522 387.946 465.296 248.469 328.554 223.656 274.359 495.557 157.99 509.173 411.423 581.264 396.631 200.897 357.175 502.101 388.516 347.302 581.511 260.064 240.486 434.589 182.026 438.554 354.779 250.981 363.022 354.81 319.57 371.675 407.959 197.036 542.874 670.035 265.204 399.525 230.231 435.089 420.33 375.483 319.247 376.856 460.529 240.22 374.974 430.694 299.179 402.999 459.399 425.736 388.748 374.663 367.954 343.916 455.944 410.161 328.576 341.038 0.000366221 139.882 267.835
SC
7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 6 6 6
M AN U
TE D
RAB8A_MOUSE Ras-related protein Rab-8A LARP7_MOUSE La-related protein 7 NCKP1_MOUSE Nck-associated protein 1 CHSP1_MOUSE Calcium-regulated heat stable protein 1 COR1C_MOUSE Coronin-1C ZO1_MOUSE Tight junction protein ZO-1 PPIH_MOUSE Isoform 2 of Peptidyl-prolyl cis-trans isomerase H DEK_MOUSE Protein DEK MPI_MOUSE Mannose-6-phosphate isomerase SQSTM_MOUSE Sequestosome-1 NUDT5_MOUSE ADP-sugar pyrophosphatase COMD8_MOUSE COMM domain-containing protein 8 DIAP2_MOUSE Protein diaphanous homolog 2 TRM5_MOUSE tRNA (guanine(37)-N1)-methyltransferase STAM1_MOUSE Signal transducing adapter molecule 1 MSRA_MOUSE Mitochondrial peptide methionine sulfoxide reductase RBM5_MOUSE RNA-binding protein 5 YIF1A_MOUSE Protein YIF1A E9Q6J5_MOUSE Protein Bod1l UCKL1_MOUSE Uridine-cytidine kinase-like 1 ALKB5_MOUSE RNA demethylase ALKBH5 NEMO_MOUSE NF-kappa-B essential modulator ATOX1_MOUSE Copper transport protein ATOX1 MCTS1_MOUSE Malignant T-cell-amplified sequence 1 CDC16_MOUSE Cell division cycle protein 16 homolog MPP7_MOUSE MAGUK p55 subfamily member 7 SEP15_MOUSE 15 kDa selenoprotein CD11B_MOUSE Cyclin-dependent kinase 11B GID8_MOUSE Glucose-induced degradation protein 8 homolog CSK21_MOUSE Casein kinase II subunit alpha LEO1_MOUSE RNA polymerase-associated protein LEO1 TMF1_MOUSE TATA element modulatory factor CHIP_MOUSE STIP1 homology and U box-containing protein 1 PSB2_MOUSE Proteasome subunit beta type-2 ZADH2_MOUSE Zinc-binding alcohol dehydrogenase domain-containing protein 2 SRA1_MOUSE Steroid receptor RNA activator 1 OSBP1_MOUSE Oxysterol-binding protein 1 AFAP1_MOUSE Actin filament-associated protein 1 LMNB2_MOUSE Lamin-B2 NMI_MOUSE N-myc-interactor SRSF5_MOUSE Serine/arginine-rich splicing factor 5 UQCC2_MOUSE Ubiquinol-cytochrome-c reductase complex assembly factor 2 NUDT9_MOUSE ADP-ribose pyrophosphatase, mitochondrial RD23A_MOUSE UV excision repair protein RAD23 homolog A PAF1_MOUSE RNA polymerase II-associated factor 1 homolog T2FA_MOUSE General transcription factor IIF subunit 1 S10A1_MOUSE Protein S100-A1 SNX1_MOUSE Sorting nexin-1 G6PE_MOUSE GDH/6PGL endoplasmic bifunctional protein UAP1L_MOUSE UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 UFC1_MOUSE Ubiquitin-fold modifier-conjugating enzyme 1 PURA_MOUSE Transcriptional activator protein Pur-alpha FTO_MOUSE Alpha-ketoglutarate-dependent dioxygenase FTO NEB2_MOUSE Neurabin-2 LUC7L_MOUSE Putative RNA-binding protein Luc7-like 1 TXLNG_MOUSE Gamma-taxilin SRP09_MOUSE Signal recognition particle 9 kDa protein NIBAN_MOUSE Protein Niban AGAL_MOUSE Alpha-galactosidase A CNBP_MOUSE Cellular nucleic acid-binding protein SYUG_MOUSE Gamma-synuclein DDX58_MOUSE Probable ATP-dependent RNA helicase DDX58
EP
Rab8a Larp7 Nckap1 Carhsp1 Coro1c Tjp1 Ppih Dek Mpi Sqstm1 Nudt5 Commd8 Diaph2 Trmt5 Stam Msra Rbm5 Yif1a Bod1l Uckl1 Alkbh5 Ikbkg Atox1 Mcts1 Cdc16 Mpp7 15-Sep Cdk11b Gid8 Csnk2a1 Leo1 Tmf1 Stub1 Psmb2 Zadh2 Sra1 Osbp Afap1 Lmnb2 Nmi Srsf5 Uqcc2 Nudt9 Rad23a Paf1 Gtf2f1 S100a1 Snx1 H6pd Uap1l1 Ufc1 Pura Fto Ppp1r9b Luc7l Txlng Srp9 Fam129a Gla Cnbp Sncg Ddx58
AC C
sp|P55258|RAB8A_MOUSE sp|Q05CL8|LARP7_MOUSE sp|P28660|NCKP1_MOUSE sp|Q9CR86|CHSP1_MOUSE sp|Q9WUM4|COR1C_MOUSE sp|P39447|ZO1_MOUSE sp|Q9D868-2|PPIH_MOUSE sp|Q7TNV0|DEK_MOUSE sp|Q924M7|MPI_MOUSE sp|Q64337|SQSTM_MOUSE sp|Q9JKX6|NUDT5_MOUSE sp|Q9CZG3|COMD8_MOUSE sp|O70566|DIAP2_MOUSE sp|Q9D0C4|TRM5_MOUSE sp|P70297|STAM1_MOUSE sp|Q9D6Y7|MSRA_MOUSE sp|Q91YE7|RBM5_MOUSE sp|Q91XB7|YIF1A_MOUSE tr|E9Q6J5|E9Q6J5_MOUSE sp|Q91YL3|UCKL1_MOUSE sp|Q3TSG4|ALKB5_MOUSE sp|O88522|NEMO_MOUSE sp|O08997|ATOX1_MOUSE sp|Q9DB27|MCTS1_MOUSE sp|Q8R349|CDC16_MOUSE sp|Q8BVD5|MPP7_MOUSE sp|Q9ERR7|SEP15_MOUSE sp|P24788|CD11B_MOUSE sp|Q9D7M1|GID8_MOUSE sp|Q60737|CSK21_MOUSE sp|Q5XJE5|LEO1_MOUSE sp|B9EKI3|TMF1_MOUSE sp|Q9WUD1|CHIP_MOUSE sp|Q9R1P3|PSB2_MOUSE sp|Q8BGC4|ZADH2_MOUSE sp|Q80VJ2|SRA1_MOUSE sp|Q3B7Z2|OSBP1_MOUSE sp|Q80YS6|AFAP1_MOUSE sp|P21619|LMNB2_MOUSE sp|O35309|NMI_MOUSE sp|O35326|SRSF5_MOUSE sp|Q9CQY6|UQCC2_MOUSE sp|Q8BVU5|NUDT9_MOUSE sp|P54726|RD23A_MOUSE sp|Q8K2T8|PAF1_MOUSE sp|Q3THK3|T2FA_MOUSE sp|P56565|S10A1_MOUSE sp|Q9WV80|SNX1_MOUSE sp|Q8CFX1|G6PE_MOUSE sp|Q3TW96|UAP1L_MOUSE sp|Q9CR09|UFC1_MOUSE sp|P42669|PURA_MOUSE sp|Q8BGW1|FTO_MOUSE sp|Q6R891|NEB2_MOUSE sp|Q9CYI4|LUC7L_MOUSE sp|Q8BHN1|TXLNG_MOUSE sp|P49962|SRP09_MOUSE sp|Q3UW53|NIBAN_MOUSE sp|P51569|AGAL_MOUSE sp|P53996|CNBP_MOUSE sp|Q9Z0F7|SYUG_MOUSE sp|Q6Q899|DDX58_MOUSE
605.325 330.511 404.114 412.421 220.894 335.283 215.692 226.933 311.831 309.572 496.393 356.103 392.104 372.509 188.574 290.094 370.612 361.62 282.61 547.375 216.427 244.44 398.917 147.319 376.001 338.66 225.207 281.483 300.293 240.147 341.273 382.229 184.541 531.111 610.759 220.612 339.897 211.151 310.712 350.421 390.818 227.878 299.825 437.209 233.812 304.951 336.319 233.806 357.886 320.434 353.716 294.124 298.202 308.016 274.061 307.5 241.967 188.48 176.717 4.14423 267.289 481.339
539.149 428.639 447.345 427.415 607.528 379.267 315.268 731.587 477.333 545.376 603.491 254.964 574.279 418.336 371.059 163.562 392.409 479.424 133.548 524.556 319.157 251.94 247.885 233.048 575.279 269.885 270.532 331.591 278.565 354.033 234.989 345.392 343.709 487.508 287.129 251.473 277.728 403.067 258.353 327.863 266.412 184.665 494.356 388.373 248.081 301.222 205.087 218.59 241.722 396.876 339.492 339.36 161.336 229.051 392.363 279.815 445.433 363.141 529.838 496.05 90.1862 486.852
570.048 580.217 378.893 1060.68 536.33 730.254 490.464 725.937 587.783 721.344 1269.34 591.115 399.222 594.509 462.474 360.183 722.646 576.562 333.992 386.513 375.865 497.714 968.111 277.918 503.606 421.429 481.128 320.015 640.904 258.003 639.707 778.52 642.818 384.96 304.887 596.561 344.647 538.426 382.484 676.618 725.638 315.03 1237.65 795.065 521.806 515.106 822.174 214.071 220.933 294.483 449.857 363.087 342.679 439.496 610.213 426.996 532.258 349.833 614.49 2093.64 106.382 339.395
0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.93 0.93 0.92 0.92 0.91 0.91 0.91 0.91 0.90 0.90 0.90 0.90 0.90 0.89 0.89 0.89 0.89 0.89 0.89 0.88 0.88 0.88 0.88 0.87 0.87 0.87 0.87 0.86 0.86 0.85 0.85 0.85 0.84 0.84 0.84 0.80 0.80 0.76 0.70 0.66 3.19 2.06 1.80
0.97 1.27 1.09 1.49 2.31 1.54 1.70 2.62 1.32 2.48 1.75 0.97 0.89 1.29 1.94 0.76 1.18 1.35 0.69 0.81 1.38 1.46 1.28 1.36 1.32 0.98 1.40 0.96 1.29 1.06 1.09 1.25 2.21 0.85 0.47 1.54 0.82 1.97 0.81 1.24 1.13 0.85 2.26 1.13 1.45 1.05 1.18 0.73 0.62 0.83 0.92 0.96 0.68 0.86 1.36 0.80 1.32 1.15 2.03 792.51 0.66 1.46
ACCEPTED MANUSCRIPT
107.147 227.918 293.724 324.055 245.223 285.077 302.876 347.056 491.608 317.22 213.364 264.333 209.206 367.145 283.11 183.321 187.753 489.529 228.716 245.309 148.088 232.202 166.294 241.803 218.74 326.262 261.377 270.524 255.062 194.447 317.328 270.902 168.184 309.233 302.599 259.874 281.053 319.652 284.796 253.567 205.223 346.496 456.069 212.752 356.565 183.643 275.409 321.795 228.893 228.457 276.399 195.514 210.249 272.262 610.352 390.756 186.117 294.509 170.322 286.561 255.712 159.785
142.544 242.786 482.432 388.932 409.033 436.471 484.528 549.836 807.112 526.097 298.962 533.941 306.345 571.322 542.465 317.197 288.371 614.972 446.372 399.731 255.595 269.258 197.338 280.679 350.784 444.002 271.346 345.158 327.367 281.813 448.308 459.28 301.222 429.767 360.262 358.439 474.866 440.364 448.006 320.254 306.289 559.317 597.319 321.095 495.132 217.065 389.879 410.1 272.92 234.676 317.065 292.051 268.925 375.377 738.898 518.83 266.27 396.304 172.57 375.394 331.606 244.014
RI PT
97.3294 153.035 329.616 313.585 242.624 271.392 309.59 341.693 429.876 386.147 231.164 326.416 205.932 398.896 342.939 208.536 205.261 389.717 316.734 281.482 193.515 184.476 138.466 193.05 250.275 294.512 215.872 269.959 252.12 215.361 317.154 311.033 227.895 320.906 294.467 266.991 344.583 349.994 337.065 273.264 231.886 470.969 420.775 258.892 390.494 147.836 338.663 268.681 257.257 232.57 251.738 235.842 224.932 310.973 548.656 407.666 219.256 308.204 118.356 289.638 256.361 199.288
SC
6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
M AN U
TE D
Fam210a Alcam Hsd17b7 Myo5a Ctnnd1 Ndufa7 Lpgat1 Srpr Eif2b2 Nbas Rps6ka3 Ndufb7 Rtn4 Casp3 Aak1 Dkc1 Swap70 Mrps30 Rai14 Nr3c1 Itga5 H2-K1 Exoc2 Oxa1l Adsl Nup155 Gapvd1 Rasa3 Tm9sf2 Fbl Rasa1 Adck1 Dock7 Tapt1 Atad1 Ralb Dtd1 Thumpd3 Mrps10 Mcat Skiv2l2 Ndufc2 Zyx Cpq Ubxn6 Nat10 Arsb Pgm3 Vars Arf4 Cyp20a1 B2m Trappc8 Fahd1 Elmo2 Pycr2 Rabgap1 Nek9 Usp25
C10_MOUSE Protein C10 UBC12_MOUSE NEDD8-conjugating enzyme Ubc12 ENV1_MOUSE MLV-related proviral Env polyprotein F210A_MOUSE Protein FAM210A CD166_MOUSE CD166 antigen DHB7_MOUSE 3-keto-steroid reductase MYO5A_MOUSE Unconventional myosin-Va CTND1_MOUSE Catenin delta-1 NDUA7_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 LGAT1_MOUSE Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 SRPR_MOUSE Signal recognition particle receptor subunit alpha EI2BB_MOUSE Translation initiation factor eIF-2B subunit beta E9Q411_MOUSE Protein Nbas KS6A3_MOUSE Ribosomal protein S6 kinase alpha-3 NDUB7_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 RTN4_MOUSE Reticulon-4 CASP3_MOUSE Caspase-3 AAK1_MOUSE AP2-associated protein kinase 1 DKC1_MOUSE H/ACA ribonucleoprotein complex subunit 4 SWP70_MOUSE Switch-associated protein 70 RT30_MOUSE 28S ribosomal protein S30, mitochondrial RAI14_MOUSE Ankycorbin GCR_MOUSE Glucocorticoid receptor ITA5_MOUSE Integrin alpha-5 HA1B_MOUSE H-2 class I histocompatibility antigen, K-B alpha chain EXOC2_MOUSE Exocyst complex component 2 OXA1L_MOUSE Mitochondrial inner membrane protein OXA1L PUR8_MOUSE Adenylosuccinate lyase NU155_MOUSE Nuclear pore complex protein Nup155 GAPD1_MOUSE GTPase-activating protein and VPS9 domain-containing protein 1 RASA3_MOUSE Ras GTPase-activating protein 3 TM9S2_MOUSE Transmembrane 9 superfamily member 2 FBRL_MOUSE rRNA 2'-O-methyltransferase fibrillarin E9PYG6_MOUSE Protein Rasa1 ADCK1_MOUSE Uncharacterized aarF domain-containing protein kinase 1 DOCK7_MOUSE Dedicator of cytokinesis protein 7 TAPT1_MOUSE Transmembrane anterior posterior transformation protein 1 ATAD1_MOUSE ATPase family AAA domain-containing protein 1 RALB_MOUSE Ras-related protein Ral-B DTD1_MOUSE D-tyrosyl-tRNA(Tyr) deacylase 1 THUM3_MOUSE THUMP domain-containing protein 3 RT10_MOUSE 28S ribosomal protein S10, mitochondrial FABD_MOUSE Malonyl-CoA-acyl carrier protein transacylase, mitochondrial SK2L2_MOUSE Superkiller viralicidic activity 2-like 2 NDUC2_MOUSE NADH dehydrogenase [ubiquinone] 1 subunit C2 ZYX_MOUSE Zyxin CBPQ_MOUSE Carboxypeptidase Q UBXN6_MOUSE UBX domain-containing protein 6 NAT10_MOUSE N-acetyltransferase 10 ARSB_MOUSE Arylsulfatase B AGM1_MOUSE Phosphoacetylglucosamine mutase SYVC_MOUSE Valine--tRNA ligase ARF4_MOUSE ADP-ribosylation factor 4 CP20A_MOUSE Cytochrome P450 20A1 B2MG_MOUSE Beta-2-microglobulin E9PWG2_MOUSE Protein Trappc8 FAHD1_MOUSE Acylpyruvase FAHD1, mitochondrial ELMO2_MOUSE Isoform 2 of Engulfment and cell motility protein 2 P5CR2_MOUSE Pyrroline-5-carboxylate reductase 2 RBGP1_MOUSE Rab GTPase-activating protein 1 NEK9_MOUSE Serine/threonine-protein kinase Nek9 UBP25_MOUSE Ubiquitin carboxyl-terminal hydrolase 25
EP
Grcc10 Ube2m
AC C
sp|O35127|C10_MOUSE sp|P61082|UBC12_MOUSE sp|P10404|ENV1_MOUSE sp|Q8BGY7|F210A_MOUSE sp|Q61490|CD166_MOUSE sp|O88736|DHB7_MOUSE sp|Q99104|MYO5A_MOUSE sp|P30999|CTND1_MOUSE sp|Q9Z1P6|NDUA7_MOUSE sp|Q91YX5|LGAT1_MOUSE sp|Q9DBG7|SRPR_MOUSE sp|Q99LD9|EI2BB_MOUSE tr|E9Q411|E9Q411_MOUSE sp|P18654|KS6A3_MOUSE sp|Q9CR61|NDUB7_MOUSE sp|Q99P72|RTN4_MOUSE sp|P70677|CASP3_MOUSE sp|Q3UHJ0|AAK1_MOUSE sp|Q9ESX5|DKC1_MOUSE sp|Q6A028|SWP70_MOUSE sp|Q9D0G0|RT30_MOUSE sp|Q9EP71|RAI14_MOUSE sp|P06537|GCR_MOUSE sp|P11688|ITA5_MOUSE sp|P01901|HA1B_MOUSE sp|Q9D4H1|EXOC2_MOUSE sp|Q8BGA9|OXA1L_MOUSE sp|P54822|PUR8_MOUSE sp|Q99P88|NU155_MOUSE sp|Q6PAR5|GAPD1_MOUSE sp|Q60790|RASA3_MOUSE sp|P58021|TM9S2_MOUSE sp|P35550|FBRL_MOUSE tr|E9PYG6|E9PYG6_MOUSE sp|Q9D0L4|ADCK1_MOUSE sp|Q8R1A4|DOCK7_MOUSE sp|Q4VBD2|TAPT1_MOUSE sp|Q9D5T0|ATAD1_MOUSE sp|Q9JIW9|RALB_MOUSE sp|Q9DD18|DTD1_MOUSE sp|P97770|THUM3_MOUSE sp|Q80ZK0|RT10_MOUSE sp|Q8R3F5|FABD_MOUSE sp|Q9CZU3|SK2L2_MOUSE sp|Q9CQ54|NDUC2_MOUSE sp|Q62523|ZYX_MOUSE sp|Q9WVJ3|CBPQ_MOUSE sp|Q99PL6|UBXN6_MOUSE sp|Q8K224|NAT10_MOUSE sp|P50429|ARSB_MOUSE sp|Q9CYR6|AGM1_MOUSE sp|Q9Z1Q9|SYVC_MOUSE sp|P61750|ARF4_MOUSE sp|Q8BKE6|CP20A_MOUSE sp|P01887|B2MG_MOUSE tr|E9PWG2|E9PWG2_MOUSE sp|Q8R0F8|FAHD1_MOUSE sp|Q8BHL5-2|ELMO2_MOUSE sp|Q922Q4|P5CR2_MOUSE sp|A2AWA9|RBGP1_MOUSE sp|Q8K1R7|NEK9_MOUSE sp|P57080|UBP25_MOUSE
203.485 396.882 426.179 540.316 301.259 369.617 402.606 442.511 516.161 456.386 319.655 277.209 263.423 477.301 313.442 210.414 239.323 563.117 272.142 293.529 193.817 274.696 200.184 285.717 258.907 356.104 338.544 344.174 318.098 238.189 356.694 278.524 200.467 359.583 386.706 299.014 304.628 393.037 321.299 327.158 228.086 437.328 471.228 253.423 412.405 184.04 350.726 300.753 311.835 316.59 312.801 222.343 249.835 318.72 639.971 430.939 215.633 319.755 169.592 303.595 271.151 177.329
238.556 858.935 401.04 372.528 327.487 392.24 693.922 406.477 494.822 448.926 291.952 236.884 346.257 550.18 444.157 258.633 359.915 275.616 334.559 239.648 115.463 352.21 213.019 345.419 115.735 463.266 195.373 731.409 526.45 564.431 203.208 353.749 289.328 372.533 248.606 390.036 377.036 360.273 314.277 196.52 284.738 166.698 470.414 356.867 454.142 276.288 296.596 282.219 275.149 209.389 314.534 372.534 361.434 292.598 240.26 506.082 237.365 313.573 408.719 349.933 210.25 167.093
432.8 1374.64 394.569 329.166 406.541 222.352 449.789 485.802 439.537 312.073 249.719 165.951 285.058 596.787 418.942 204.13 265.117 299.18 166.144 227.908 132.026 421.417 235.974 337.524 133.836 373.936 170.561 443.277 316.885 549.24 163.917 186.074 122.491 305.957 281.919 329.587 365.076 273.139 183.45 200.674 281.993 280.567 913.508 244.919 376.112 680.719 221.134 361.254 137.669 157.782 191.929 226.02 397.52 276.383 792.134 646.625 355.492 327.596 321.254 305.485 121.552 183.746
1.69 1.68 1.46 1.46 1.46 1.45 1.45 1.44 1.44 1.40 1.39 1.37 1.37 1.37 1.37 1.35 1.34 1.34 1.32 1.32 1.32 1.31 1.30 1.30 1.30 1.29 1.28 1.28 1.27 1.27 1.27 1.27 1.27 1.25 1.25 1.25 1.25 1.24 1.24 1.23 1.22 1.22 1.22 1.22 1.21 1.21 1.21 1.20 1.20 1.20 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.18 1.18 1.17
3.28 5.86 1.28 1.10 1.50 1.10 1.87 1.30 1.01 1.08 1.22 0.68 1.52 1.50 1.38 1.18 1.59 0.65 0.92 0.89 0.72 1.86 1.47 1.57 0.53 1.35 0.77 2.17 1.66 2.72 0.58 0.93 1.04 1.08 0.89 1.37 1.19 0.95 0.80 0.75 1.30 0.55 1.58 1.28 1.11 2.89 0.84 1.09 0.85 0.80 0.96 1.39 1.74 0.98 0.89 1.44 1.46 1.06 2.53 1.14 0.65 0.98
ACCEPTED MANUSCRIPT
Enah Prorsd1 U2af2 Trappc5 Usp39 Ganc Kank2 Mrpl51 Fam136a Vbp1 Aoc3 Lin7c
TE D
227.492 344.957 342.896 261.288 328.535 231.854 277.541 162.512 249.841 326.488 332.973 226.066 211.71 319.021 198.864 182.322 226.647 292.697 190.222 450.561 288.992 220.263 217.184 336.928 328.452 152.885 236.471 185.711 187.223 269.943 362.632 327.794 231.276 314.492 236.383 467.749 433.733 333.464 349.336 202.72 321.117 306.918 223.592 495.881 263.279 280.912 169.631 408.173 272.492 194.491 261.299 253.259 244.33 301.606 277.641 289.388 320.764 400.407 371.409 311.302 301.413 241.563
300.044 536.692 463.261 428.979 355.826 271.494 325.671 276.625 325.734 449.884 405.858 348.359 307.994 432.751 236.288 258.765 266.856 413.862 254.162 555.588 366.134 345.895 291.204 394.56 378.88 194.312 293.27 253.349 251.093 361.389 483.605 383.339 349.295 446.757 245.009 385.572 385.084 471.907 489.995 270.145 297.625 332.73 306.736 677.491 340.289 309.798 189.744 516.626 366.794 227.669 282.15 298.37 284.495 308.203 344.1 322.245 347.817 479.657 311.976 333.319 375.746 258.411
RI PT
239.7 364.509 364.048 371.206 316.573 210.605 229.31 233.487 245.55 347.301 337.6 308.109 197.792 355.518 218.581 205.594 246.43 290.756 206.651 526.233 271.088 292.38 262.922 322.31 295.12 162.757 270.78 221.077 220.225 317.006 435.759 349.526 315.394 371.649 240.797 428.241 318.017 395.773 418.458 226.933 241.64 293.77 283.499 613.809 305.318 252.292 167.943 469.322 344.456 186.86 232.233 247.061 253.299 290.505 303.904 326.075 338.221 409.456 275.464 289.29 373.793 227.464
SC
6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
M AN U
NAA35_MOUSE N-alpha-acetyltransferase 35, NatC auxiliary subunit PSME2_MOUSE Proteasome activator complex subunit 2 CDC73_MOUSE Parafibromin COQ6_MOUSE Ubiquinone biosynthesis monooxygenase COQ6 TBCD_MOUSE Tubulin-specific chaperone D GOGA1_MOUSE Golgin subfamily A member 1 UT14A_MOUSE U3 small nucleolar RNA-associated protein 14 homolog A ABCA1_MOUSE ATP-binding cassette sub-family A member 1 LONP2_MOUSE Lon protease homolog 2, peroxisomal AKAP9_MOUSE A-kinase anchor protein 9 DHAK_MOUSE Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) DAB2P_MOUSE Disabled homolog 2-interacting protein UFM1_MOUSE Ubiquitin-fold modifier 1 RO60_MOUSE 60 kDa SS-A/Ro ribonucleoprotein BAG6_MOUSE Large proline-rich protein BAG6 ERGI3_MOUSE Endoplasmic reticulum-Golgi intermediate compartment protein 3 STOM_MOUSE Erythrocyte band 7 integral membrane protein EHD3_MOUSE EH domain-containing protein 3 ERGI1_MOUSE Endoplasmic reticulum-Golgi intermediate compartment protein 1 ELMD2_MOUSE ELMO domain-containing protein 2 TATD1_MOUSE Putative deoxyribonuclease TATDN1 PTN23_MOUSE Tyrosine-protein phosphatase non-receptor type 23 PDIA5_MOUSE Protein disulfide-isomerase A5 CK5P3_MOUSE CDK5 regulatory subunit-associated protein 3 FKBP8_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP8 RASK_MOUSE GTPase KRas PGLT1_MOUSE Protein O-glucosyltransferase 1 VP33A_MOUSE Vacuolar protein sorting-associated protein 33A ARC1B_MOUSE Actin-related protein 2/3 complex subunit 1B LACB2_MOUSE Beta-lactamase-like protein 2 J3KMM1_MOUSE Ubiquitin carboxyl-terminal hydrolase ZN326_MOUSE DBIRD complex subunit ZNF326 DJC11_MOUSE DnaJ homolog subfamily C member 11 HSP13_MOUSE Heat shock 70 kDa protein 13 NU107_MOUSE Nuclear pore complex protein Nup107 CSN6_MOUSE COP9 signalosome complex subunit 6 MFAP1_MOUSE Microfibrillar-associated protein 1 VPS45_MOUSE Vacuolar protein sorting-associated protein 45 FMO1_MOUSE Dimethylaniline monooxygenase [N-oxide-forming] 1 STX12_MOUSE Syntaxin-12 LARP4_MOUSE La-related protein 4 PDIP3_MOUSE Polymerase delta-interacting protein 3 ABCF3_MOUSE ATP-binding cassette sub-family F member 3 EIF2A_MOUSE Eukaryotic translation initiation factor 2A GRDN_MOUSE Girdin HSBP1_MOUSE Heat shock factor-binding protein 1 COMT_MOUSE Catechol O-methyltransferase PNPH_MOUSE Purine nucleoside phosphorylase RHG17_MOUSE Rho GTPase-activating protein 17 CL065_MOUSE Probable peptide chain release factor C12orf65 homolog, mitochondrial ENAH_MOUSE Protein enabled homolog PRXD1_MOUSE Prolyl-tRNA synthetase associated domain-containing protein 1 U2AF2_MOUSE Splicing factor U2AF 65 kDa subunit TPPC5_MOUSE Trafficking protein particle complex subunit 5 SNUT2_MOUSE U4/U6.U5 tri-snRNP-associated protein 2 GANC_MOUSE Neutral alpha-glucosidase C KANK2_MOUSE KN motif and ankyrin repeat domain-containing protein 2 RM51_MOUSE 39S ribosomal protein L51, mitochondrial F136A_MOUSE Protein FAM136A PFD3_MOUSE Prefoldin subunit 3 AOC3_MOUSE Membrane primary amine oxidase LIN7C_MOUSE Protein lin-7 homolog C
EP
Naa35 Psme2 Cdc73 Coq6 Tbcd Golga1 Utp14a Abca1 Lonp2 Akap9 Dak Dab2ip Ufm1 Trove2 Bag6 Ergic3 Stom Ehd3 Ergic1 Elmod2 Tatdn1 Ptpn23 Pdia5 Cdk5rap3 Fkbp8 Kras Poglut1 Vps33a Arpc1b Lactb2 Usp19 Znf326 Dnajc11 Hspa13 Nup107 Cops6 Mfap1 Vps45 Fmo1 Stx12 Larp4 Poldip3 Abcf3 Eif2a Ccdc88a Hsbp1 Comt Pnp Arhgap17
AC C
sp|Q6PHQ8|NAA35_MOUSE sp|P97372|PSME2_MOUSE sp|Q8JZM7|CDC73_MOUSE sp|Q8R1S0|COQ6_MOUSE sp|Q8BYA0|TBCD_MOUSE sp|Q9CW79|GOGA1_MOUSE sp|Q640M1|UT14A_MOUSE sp|P41233|ABCA1_MOUSE sp|Q9DBN5|LONP2_MOUSE sp|Q70FJ1|AKAP9_MOUSE sp|Q8VC30|DHAK_MOUSE sp|Q3UHC7|DAB2P_MOUSE sp|P61961|UFM1_MOUSE sp|O08848|RO60_MOUSE sp|Q9Z1R2|BAG6_MOUSE sp|Q9CQE7|ERGI3_MOUSE sp|P54116|STOM_MOUSE sp|Q9QXY6|EHD3_MOUSE sp|Q9DC16|ERGI1_MOUSE sp|Q8BGF6|ELMD2_MOUSE sp|Q6P8M1|TATD1_MOUSE sp|Q6PB44|PTN23_MOUSE sp|Q921X9|PDIA5_MOUSE sp|Q99LM2|CK5P3_MOUSE sp|O35465|FKBP8_MOUSE sp|P32883|RASK_MOUSE sp|Q8BYB9|PGLT1_MOUSE sp|Q9D2N9|VP33A_MOUSE sp|Q9WV32|ARC1B_MOUSE sp|Q99KR3|LACB2_MOUSE tr|J3KMM1|J3KMM1_MOUSE sp|O88291|ZN326_MOUSE sp|Q5U458|DJC11_MOUSE sp|Q8BM72|HSP13_MOUSE sp|Q8BH74|NU107_MOUSE sp|O88545|CSN6_MOUSE sp|Q9CQU1|MFAP1_MOUSE sp|P97390|VPS45_MOUSE sp|P50285|FMO1_MOUSE sp|Q9ER00|STX12_MOUSE sp|Q8BWW4|LARP4_MOUSE sp|Q8BG81|PDIP3_MOUSE sp|Q8K268|ABCF3_MOUSE sp|Q8BJW6|EIF2A_MOUSE sp|Q5SNZ0|GRDN_MOUSE sp|Q9CQZ1|HSBP1_MOUSE sp|O88587|COMT_MOUSE sp|P23492|PNPH_MOUSE sp|Q3UIA2|RHG17_MOUSE sp|Q80VP5|CL065_MOUSE sp|Q03173|ENAH_MOUSE sp|Q9D820|PRXD1_MOUSE sp|P26369|U2AF2_MOUSE sp|Q9CQA1|TPPC5_MOUSE sp|Q3TIX9|SNUT2_MOUSE sp|Q8BVW0|GANC_MOUSE sp|Q8BX02|KANK2_MOUSE sp|Q9CPY1|RM51_MOUSE sp|Q9CR98|F136A_MOUSE sp|P61759|PFD3_MOUSE sp|O70423|AOC3_MOUSE sp|O88952|LIN7C_MOUSE
247.928 295.327 365.755 311.952 396.978 242.962 263.344 183.338 248.812 329.803 365.456 265.729 161.159 339.189 240.819 184.523 272.07 250.599 197.452 551.757 267.615 233.821 249.121 346.881 322.121 160.08 275.927 202.895 204.501 291.998 404.028 368.507 257.514 314.736 280.584 599.006 439.296 326.676 350.426 200.065 318.218 324.537 247.167 529.476 277.618 268.507 175.849 431.131 295.81 181.525 246.905 237.711 248.208 323.342 271.242 328.453 347.757 373.608 367.111 296.016 329.543 229.882
337.802 669.375 369.524 157.795 308.948 201.004 258.47 104.469 408.809 332.208 331.132 147.97 124.057 523.192 225.178 198.895 136.23 333.897 257.134 484.486 282.108 303.318 255.979 423.691 404.074 195.503 208.511 162.543 976.038 108.979 377.875 411.878 560.229 344.54 580.424 733.267 162.285 320.553 144.506 297.999 334.421 248.308 193.943 482.695 264.61 165.104 421.452 728.624 295.809 252.636 342.592 136.476 344.395 356.946 318.059 286.988 266.632 318.882 257.61 330.987 162.124 208.929
323.617 605.962 492.424 306.176 365.768 430.614 297.333 116.923 332.01 590.035 441.154 416.858 309.744 449.181 463.87 148.307 81.4129 463.298 173.779 434.831 500.337 341.134 197.956 422.498 373.581 227.66 197.215 169.364 672.995 223.286 741.083 1236.67 263.382 349.002 318.834 659.21 406.077 292.862 157.646 463.538 902.726 481.624 256.455 392.633 500.643 542.54 564.191 1153.9 227.434 336.952 692.997 213.063 542.284 297.563 216.514 232.585 371.442 482.302 699.462 561.598 177.861 408.619
1.17 1.17 1.17 1.17 1.17 1.16 1.16 1.16 1.16 1.16 1.15 1.15 1.15 1.14 1.14 1.14 1.14 1.14 1.14 1.13 1.13 1.13 1.13 1.12 1.12 1.12 1.12 1.12 1.12 1.11 1.11 1.11 1.11 1.11 1.10 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.05 1.05 1.05 1.04 1.04
1.42 1.80 1.22 0.73 1.05 1.43 1.10 0.56 1.50 1.37 1.15 1.06 1.06 1.44 1.65 0.90 0.46 1.37 1.09 0.94 1.40 1.26 0.95 1.28 1.25 1.34 0.80 0.82 4.05 0.57 1.40 2.43 1.51 1.01 1.88 1.55 0.76 0.84 0.39 1.77 2.20 1.22 0.89 0.79 1.35 1.33 2.92 2.15 0.85 1.55 2.10 0.70 1.78 1.11 0.92 0.84 0.97 0.99 1.48 1.49 0.50 1.32
ACCEPTED MANUSCRIPT
TE D
290.927 326.81 210.312 159.088 255.69 322.01 193.289 392.215 405.996 413.952 351.998 249.992 370.146 371.984 294.495 267.467 419.267 354.433 219.214 330.432 295.254 312.215 276.327 183.815 161.745 308.909 354.232 303.862 271.663 272.745 380.977 255.376 206.229 615.951 233.291 237.195 499.605 193.5 402.603 373.744 447.402 410.057 305.436 375.197 373.028 333.854 447.756 353.573 141.231 691.438 465.99 290.333 355.167 319.504 410.221 183.734 363.997 243.562 445.679 284.752 337.457 227.257
358.206 397.982 286.921 181.414 262.108 344.156 210.936 521.286 395.432 367.316 382.723 253.885 432.262 449.727 357.937 352.599 461.683 403.861 294.504 305.268 278.9 396.514 326.688 208.251 139.739 359.806 421.835 323.029 305.245 249.303 394.743 306.81 247.691 674.883 233.633 245.978 530.973 212.365 505.037 358.883 386.794 403.206 310.398 372.834 212.768 344.531 528.485 341.82 150.894 522.361 392.567 242.038 311.572 317.029 435.873 183.18 393.489 188.208 403.773 264.244 326.785 214.46
RI PT
342.092 374.247 281.281 177.269 242.641 327.242 189.285 477.948 374.121 333.595 339.4 266.092 381.019 426.704 367.662 334.444 454.429 392.919 313.077 259.527 301.708 415.874 338.515 201.942 129.686 424.436 440.036 287.166 292.595 261.731 371.108 337.015 244.043 669.277 230.916 202.312 480.215 211.236 570.475 338.208 454.52 371.46 340.854 327.404 178.763 402.777 578.857 324.671 149.073 595.985 338.22 295.035 267.862 306.965 433.834 182.74 383.591 259.571 443.866 327.036 309.758 209.09
SC
6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
M AN U
S2540_MOUSE Solute carrier family 25 member 40 CNNM2_MOUSE Metal transporter CNNM2 XPP3_MOUSE Probable Xaa-Pro aminopeptidase 3 FA49B_MOUSE Protein FAM49B RETN_MOUSE Resistin RPAP3_MOUSE RNA polymerase II-associated protein 3 MBNL2_MOUSE Muscleblind-like protein 2 SRPK2_MOUSE SRSF protein kinase 2 ARL1_MOUSE ADP-ribosylation factor-like protein 1 BRD2_MOUSE Bromodomain-containing protein 2 FRDA_MOUSE Frataxin, mitochondrial TM9S4_MOUSE Transmembrane 9 superfamily member 4 MMAB_MOUSE Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial KIF3A_MOUSE Kinesin-like protein KIF3A RHG05_MOUSE Rho GTPase-activating protein 5 BIEA_MOUSE Biliverdin reductase A KCC1A_MOUSE Calcium/calmodulin-dependent protein kinase type 1 EPN1_MOUSE Epsin-1 SF3B6_MOUSE Splicing factor 3B subunit 6 B1AWE0_MOUSE Clathrin light chain A RAB6A_MOUSE Ras-related protein Rab-6A SAFB2_MOUSE Scaffold attachment factor B2 MK09_MOUSE Mitogen-activated protein kinase 9 SART3_MOUSE Squamous cell carcinoma antigen recognized by T-cells 3 PGP_MOUSE Phosphoglycolate phosphatase PLOD3_MOUSE Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 ENOB_MOUSE Beta-enolase SH3G1_MOUSE Endophilin-A2 GLSK_MOUSE Glutaminase kidney isoform, mitochondrial SURF1_MOUSE Surfeit locus protein 1 ELOA1_MOUSE Transcription elongation factor B polypeptide 3 GSHB_MOUSE Glutathione synthetase RBBP6_MOUSE E3 ubiquitin-protein ligase RBBP6 VPS4B_MOUSE Vacuolar protein sorting-associated protein 4B OGT1_MOUSE UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OTU6B_MOUSE OTU domain-containing protein 6B SF3B5_MOUSE Splicing factor 3B subunit 5 CWC27_MOUSE Peptidyl-prolyl cis-trans isomerase CWC27 homolog FUCO_MOUSE Tissue alpha-L-fucosidase ZC21A_MOUSE Zinc finger C2HC domain-containing protein 1A TMED2_MOUSE Transmembrane emp24 domain-containing protein 2 ABI1_MOUSE Abl interactor 1 RABL6_MOUSE Rab-like protein 6 A16L1_MOUSE Autophagy-related protein 16-1 PLIN2_MOUSE Perilipin-2 ADPRH_MOUSE [Protein ADP-ribosylarginine] hydrolase PPA6_MOUSE Lysophosphatidic acid phosphatase type 6 UBAC1_MOUSE Ubiquitin-associated domain-containing protein 1 GALK1_MOUSE Galactokinase CATZ_MOUSE Cathepsin Z ESF1_MOUSE ESF1 homolog TXN4A_MOUSE Thioredoxin-like protein 4A NT5C_MOUSE 5'(3')-deoxyribonucleotidase, cytosolic type PEX5_MOUSE Isoform 2 of Peroxisomal targeting signal 1 receptor QORL1_MOUSE Quinone oxidoreductase-like protein 1 IF6_MOUSE Eukaryotic translation initiation factor 6 PPT1_MOUSE Palmitoyl-protein thioesterase 1 VP26B_MOUSE Vacuolar protein sorting-associated protein 26B HDGR2_MOUSE Hepatoma-derived growth factor-related protein 2 Q91X76_MOUSE 5'-nucleotidase domain containing 2 SMAP_MOUSE Small acidic protein 6PGL_MOUSE 6-phosphogluconolactonase
EP
Slc25a40 Cnnm2 Xpnpep3 Fam49b Retn Rpap3 Mbnl2 Srpk2 Arl1 Brd2 Fxn Tm9sf4 Mmab Kif3a Arhgap5 Blvra Camk1 Epn1 Sf3b6 Clta Rab6a Safb2 Mapk9 Sart3 Pgp Plod3 Eno3 Sh3gl1 Gls Surf1 Tceb3 Gss Rbbp6 Vps4b Ogt Otud6b Sf3b5 Cwc27 Fuca1 Zc2hc1a Tmed2 Abi1 Rabl6 Atg16l1 Plin2 Adprh Acp6 Ubac1 Galk1 Ctsz Esf1 Txnl4a Nt5c Pex5 Cryzl1 Eif6 Ppt1 Vps26b Hdgfrp2 Nt5dc2 Smap Pgls
AC C
sp|Q8BGP6|S2540_MOUSE sp|Q3TWN3|CNNM2_MOUSE sp|B7ZMP1|XPP3_MOUSE sp|Q921M7|FA49B_MOUSE sp|Q99P87|RETN_MOUSE sp|Q9D706|RPAP3_MOUSE sp|Q8C181|MBNL2_MOUSE sp|O54781|SRPK2_MOUSE sp|P61211|ARL1_MOUSE sp|Q7JJ13|BRD2_MOUSE sp|O35943|FRDA_MOUSE sp|Q8BH24|TM9S4_MOUSE sp|Q9D273|MMAB_MOUSE sp|P28741|KIF3A_MOUSE sp|P97393|RHG05_MOUSE sp|Q9CY64|BIEA_MOUSE sp|Q91YS8|KCC1A_MOUSE sp|Q80VP1|EPN1_MOUSE sp|P59708|SF3B6_MOUSE tr|B1AWE0|B1AWE0_MOUSE sp|P35279|RAB6A_MOUSE sp|Q80YR5|SAFB2_MOUSE sp|Q9WTU6|MK09_MOUSE sp|Q9JLI8|SART3_MOUSE sp|Q8CHP8|PGP_MOUSE sp|Q9R0E1|PLOD3_MOUSE sp|P21550|ENOB_MOUSE sp|Q62419|SH3G1_MOUSE sp|D3Z7P3|GLSK_MOUSE sp|P09925|SURF1_MOUSE sp|Q8CB77|ELOA1_MOUSE sp|P51855|GSHB_MOUSE sp|P97868|RBBP6_MOUSE sp|P46467|VPS4B_MOUSE sp|Q8CGY8|OGT1_MOUSE sp|Q8K2H2|OTU6B_MOUSE sp|Q923D4|SF3B5_MOUSE sp|Q3TKY6|CWC27_MOUSE sp|Q99LJ1|FUCO_MOUSE sp|Q8BJH1|ZC21A_MOUSE sp|Q9R0Q3|TMED2_MOUSE sp|Q8CBW3|ABI1_MOUSE sp|Q5U3K5|RABL6_MOUSE sp|Q8C0J2|A16L1_MOUSE sp|P43883|PLIN2_MOUSE sp|P54923|ADPRH_MOUSE sp|Q8BP40|PPA6_MOUSE sp|Q8VDI7|UBAC1_MOUSE sp|Q9R0N0|GALK1_MOUSE sp|Q9WUU7|CATZ_MOUSE sp|Q3V1V3|ESF1_MOUSE sp|P83877|TXN4A_MOUSE sp|Q9JM14|NT5C_MOUSE sp|O09012-2|PEX5_MOUSE sp|Q921W4|QORL1_MOUSE sp|O55135|IF6_MOUSE sp|O88531|PPT1_MOUSE sp|Q8C0E2|VP26B_MOUSE sp|Q3UMU9|HDGR2_MOUSE tr|Q91X76|Q91X76_MOUSE sp|Q9R0P4|SMAP_MOUSE sp|Q9CQ60|6PGL_MOUSE
300.235 328.309 221.476 164.638 249.678 320.536 179.893 365.016 399.135 393.35 320.243 270.305 327.446 356.973 310.235 254.764 419.643 349.948 241.846 287.803 320.194 331.618 286.104 175.838 150.355 367.163 363.151 260.997 251.648 277.372 343.813 273.735 193.535 579.466 219.293 182.338 423.851 181.09 438.952 331.621 486.228 351.09 311.406 302.335 310.809 351.951 441.338 298.337 123.025 686.619 362.393 305.955 270.503 267.291 350.853 157.841 302.014 279.772 421.897 298.946 267.047 184.822
372.155 272.939 160.644 354.37 50.7534 483.055 425.118 410.513 404.643 412.093 221.732 217.492 211.301 367.259 332.557 300.528 332.219 236.247 216.867 238.007 316.738 268.537 262.242 951.486 386.786 254.301 294.527 406.26 495.227 201.996 282.424 352.208 816.443 546.079 237.248 223.914 368.731 228.998 265.87 361.182 378.035 328.98 316.291 583.012 739.977 179.635 509.749 214.37 738.493 425.44 335.735 292.484 236.022 260.885 245.5 301.802 176.981 230.84 245.338 206.102 181.737 140.214
234.081 433.997 223.427 243.497 107.538 878.291 873.507 360.227 323.731 672.099 432.527 180.805 272.803 365.834 294.582 300.739 415.238 289.829 214.281 798.679 264.057 587.386 237.077 1081.51 681.765 192.639 378.842 683.965 464.444 239.551 569.185 540.287 2773.59 838.071 307.377 363.475 742.817 410.448 273.417 690.979 313.056 593.169 360.805 770.477 630.806 229.341 411.551 494.239 567.994 815.653 424.767 323.949 429.729 427.823 286.543 333.902 314.435 215.925 567.443 152.685 398.684 357.579
1.04 1.04 1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.00 1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.95 0.95 0.94 0.94 0.94 0.94 0.94 0.94 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.92 0.92 0.92
0.96 1.01 0.78 1.78 0.32 2.10 3.39 0.89 0.93 1.45 0.95 0.77 0.64 0.92 0.95 1.00 0.86 0.70 0.81 1.76 0.97 1.18 0.81 5.27 3.67 0.61 0.85 1.84 1.70 0.83 1.13 1.51 7.97 1.08 1.17 1.34 1.13 1.58 0.55 1.48 0.77 1.18 1.05 1.93 2.48 0.56 0.90 1.04 4.50 0.96 0.95 1.05 1.07 1.10 0.63 1.73 0.66 0.89 0.91 0.59 0.90 1.14
ACCEPTED MANUSCRIPT
347.373 199.448 496.216 460.357 310.381 365.662 209.167 354.568 585.252 267.495 254.101 333.52 303.538 254.305 400.304 422.43 264.868 393.609 299.359 244.797 456.849 308.695 200.776 216.752 153.956 419.336 544.38 248.126 375.87 329.295 473.757 281.487 211.063 342.016 218.499 357.996 340.804 325.816 376.289 241.926 287.404 487.859 164.363 344.837 532.035 120.463 233.474 138.256 267.026 393.999 254.357 185.794 157.116 121.677 155.214 161.278 269.996 214.57 207.455 318.722 163.198 270.361
364.753 211.526 399.769 495.274 292.961 295.692 219.383 310.581 416.066 240.169 220.013 364.989 287.91 282.739 415.44 400.94 236.127 397.487 277.666 212.933 493.235 281.989 168.99 193.913 136.369 172.493 448.469 254.827 345.367 294.926 437.349 218.544 179.084 295.815 216.202 415.497 248.596 252.611 340.235 203.544 169.828 412.265 147.512 246.197 424.681 400.782 538.396 290.069 785.415 684.821 392.556 339.906 274.194 277.777 272.304 371.447 462.099 450.889 344.304 567.576 281.984 454.786
RI PT
382.584 206.393 452.52 532.232 292.526 289.605 223.146 331.978 441.746 247.552 225.278 401.158 325.56 280.986 478.083 407.719 287.02 442.306 359.279 234.489 532.319 269.866 190.675 233.98 147.949 195.515 449.781 309.845 370.55 313.973 437.717 243.33 187.692 402.399 256.164 521.932 434.714 297.843 455.738 271.584 264.602 646.202 228.244 345.808 541.896 125.867 353.635 157.659 349.126 366.597 221.504 172.151 155.188 179.615 149.436 212.931 216.806 265.64 248.571 324.984 168.228 281.668
SC
6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
M AN U
TE D
Col4a2 Nelfe Bin1 Cpped1 Rnf40 Eif3k Nagk Rnps1 Plbd2 Rbm12 Prmt5 Brd4 Fcho2 Palm2 Cope Uprt Rbbp9 Pank3 Smndc1 Tsnax Brd3 Ccdc58 Bag4 Ube2a Ubxn1 Qsox2 Hdhd2 Vps29 Usp4 Srp19 Sardh Pcmt1 Tceb1 Spryd4 Dpp7 Gamt Snrnp27 Cnn2 Clca1 Gbp2 Ndufa9 Cidec Eefsec Itpr1 S100a4 Serpinb1a Trmu Gypc Mrpl11 Slc1a3 B3galtl Mp68 Nqo1 Mcm6
UBC9_MOUSE SUMO-conjugating enzyme UBC9 ZN207_MOUSE BUB3-interacting and GLEBS motif-containing protein ZNF207 RAE1L_MOUSE mRNA export factor MPPB_MOUSE Mitochondrial-processing peptidase subunit beta LRC47_MOUSE Leucine-rich repeat-containing protein 47 TCEA1_MOUSE Transcription elongation factor A protein 1 PITM1_MOUSE Membrane-associated phosphatidylinositol transfer protein 1 CG050_MOUSE Uncharacterized protein C7orf50 homolog CO4A2_MOUSE Collagen alpha-2(IV) chain NELFE_MOUSE Negative elongation factor E BIN1_MOUSE Myc box-dependent-interacting protein 1 CPPED_MOUSE Calcineurin-like phosphoesterase domain-containing protein 1 BRE1B_MOUSE E3 ubiquitin-protein ligase BRE1B EIF3K_MOUSE Eukaryotic translation initiation factor 3 subunit K NAGK_MOUSE N-acetyl-D-glucosamine kinase RNPS1_MOUSE RNA-binding protein with serine-rich domain 1 PLBL2_MOUSE Putative phospholipase B-like 2 RBM12_MOUSE RNA-binding protein 12 ANM5_MOUSE Protein arginine N-methyltransferase 5 BRD4_MOUSE Bromodomain-containing protein 4 FCHO2_MOUSE FCH domain only protein 2 PALM2_MOUSE Paralemmin-2 COPE_MOUSE Coatomer subunit epsilon UPP_MOUSE Uracil phosphoribosyltransferase homolog RBBP9_MOUSE Putative hydrolase RBBP9 PANK3_MOUSE Pantothenate kinase 3 SPF30_MOUSE Survival of motor neuron-related-splicing factor 30 TSNAX_MOUSE Translin-associated protein X BRD3_MOUSE Bromodomain-containing protein 3 CCD58_MOUSE Coiled-coil domain-containing protein 58 BAG4_MOUSE BAG family molecular chaperone regulator 4 UBE2A_MOUSE Ubiquitin-conjugating enzyme E2 A UBXN1_MOUSE UBX domain-containing protein 1 QSOX2_MOUSE Sulfhydryl oxidase 2 HDHD2_MOUSE Haloacid dehalogenase-like hydrolase domain-containing protein 2 VPS29_MOUSE Vacuolar protein sorting-associated protein 29 UBP4_MOUSE Ubiquitin carboxyl-terminal hydrolase 4 SRP19_MOUSE Signal recognition particle 19 kDa protein SARDH_MOUSE Sarcosine dehydrogenase, mitochondrial PIMT_MOUSE Protein-L-isoaspartate(D-aspartate) O-methyltransferase ELOC_MOUSE Transcription elongation factor B polypeptide 1 SPRY4_MOUSE SPRY domain-containing protein 4 DPP2_MOUSE Dipeptidyl peptidase 2 GAMT_MOUSE Guanidinoacetate N-methyltransferase SNR27_MOUSE U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein CNN2_MOUSE Calponin-2 Q9QX15_MOUSE Calcium-activated chloride channel regulator 1 GBP2_MOUSE Interferon-induced guanylate-binding protein 2 NDUA9_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial CIDEC_MOUSE Cell death activator CIDE-3 SELB_MOUSE Selenocysteine-specific elongation factor ITPR1_MOUSE Inositol 1,4,5-trisphosphate receptor type 1 S10A4_MOUSE Protein S100-A4 ILEUA_MOUSE Leukocyte elastase inhibitor A MTU1_MOUSE Mitochondrial tRNA-specific 2-thiouridylase 1 GLPC_MOUSE Glycophorin-C RM11_MOUSE 39S ribosomal protein L11, mitochondrial EAA1_MOUSE Excitatory amino acid transporter 1 B3GLT_MOUSE Beta-1,3-glucosyltransferase 68MP_MOUSE 6.8 kDa mitochondrial proteolipid NQO1_MOUSE NAD(P)H dehydrogenase [quinone] 1 MCM6_MOUSE DNA replication licensing factor MCM6
EP
Ube2i Znf207 Rae1 Pmpcb Lrrc47 Tcea1 Pitpnm1
AC C
sp|P63280|UBC9_MOUSE sp|Q9JMD0|ZN207_MOUSE sp|Q8C570|RAE1L_MOUSE sp|Q9CXT8|MPPB_MOUSE sp|Q505F5|LRC47_MOUSE sp|P10711|TCEA1_MOUSE sp|O35954|PITM1_MOUSE sp|Q9CXL3|CG050_MOUSE sp|P08122|CO4A2_MOUSE sp|P19426|NELFE_MOUSE sp|O08539|BIN1_MOUSE sp|Q8BFS6|CPPED_MOUSE sp|Q3U319|BRE1B_MOUSE sp|Q9DBZ5|EIF3K_MOUSE sp|Q9QZ08|NAGK_MOUSE sp|Q99M28|RNPS1_MOUSE sp|Q3TCN2|PLBL2_MOUSE sp|Q8R4X3|RBM12_MOUSE sp|Q8CIG8|ANM5_MOUSE sp|Q9ESU6|BRD4_MOUSE sp|Q3UQN2|FCHO2_MOUSE sp|Q8BR92|PALM2_MOUSE sp|O89079|COPE_MOUSE sp|B1AVZ0|UPP_MOUSE sp|O88851|RBBP9_MOUSE sp|Q8R2W9|PANK3_MOUSE sp|Q8BGT7|SPF30_MOUSE sp|Q9QZE7|TSNAX_MOUSE sp|Q8K2F0|BRD3_MOUSE sp|Q8R3Q6|CCD58_MOUSE sp|Q8CI61|BAG4_MOUSE sp|Q9Z255|UBE2A_MOUSE sp|Q922Y1|UBXN1_MOUSE sp|Q3TMX7|QSOX2_MOUSE sp|Q3UGR5|HDHD2_MOUSE sp|Q9QZ88|VPS29_MOUSE sp|P35123|UBP4_MOUSE sp|Q9D7A6|SRP19_MOUSE sp|Q99LB7|SARDH_MOUSE sp|P23506|PIMT_MOUSE sp|P83940|ELOC_MOUSE sp|Q91WK1|SPRY4_MOUSE sp|Q9ET22|DPP2_MOUSE sp|O35969|GAMT_MOUSE sp|Q8K194|SNR27_MOUSE sp|Q08093|CNN2_MOUSE tr|Q9QX15|Q9QX15_MOUSE sp|Q9Z0E6|GBP2_MOUSE sp|Q9DC69|NDUA9_MOUSE sp|P56198|CIDEC_MOUSE sp|Q9JHW4|SELB_MOUSE sp|P11881|ITPR1_MOUSE sp|P07091|S10A4_MOUSE sp|Q9D154|ILEUA_MOUSE sp|Q9DAT5|MTU1_MOUSE sp|Q78HU7|GLPC_MOUSE sp|Q9CQF0|RM11_MOUSE sp|P56564|EAA1_MOUSE sp|Q8BHT6|B3GLT_MOUSE sp|P56379|68MP_MOUSE sp|Q64669|NQO1_MOUSE sp|P97311|MCM6_MOUSE
301.525 158.701 464.15 407.291 255.074 299.895 172.177 310.829 509.988 222.234 210.361 293.393 275.283 195.584 367.561 338.403 254.253 341.328 303.614 209.077 377.182 225.094 172.232 198.615 126.148 358.609 398.964 220.307 289.728 250.717 331.157 219.139 152.834 320.644 176.467 310.318 360.219 235.975 307.221 191.321 239.458 428.06 127.2 220.206 252.941 327.376 558.548 235.927 286.47 622.328 415.14 263.64 241.269 217.835 219.444 226.71 296.573 278.049 345.882 396.804 213.994 368.907
474.71 131.268 462.582 210.861 394.715 358.475 212.674 244.716 123.172 182.527 216.088 172.539 177.823 253.879 401.822 239.055 184.319 351.704 370.891 205.156 441.164 127.958 266.745 198.571 621.312 488.719 229.923 245.189 334.453 252.154 249.033 229.126 190.919 351.327 145.55 760.31 385.805 446.079 318.94 189.416 317.611 216.278 95.5498 91.6659 330.997 151.627 121.521 118.956 430.439 115.89 418.787 519.473 205.8 139.029 138.823 134.849 132.019 136.331 233.392 352.095 367.833 378.901
810.073 250.678 748.195 952.75 590.888 575.109 193.975 321.793 178.998 356.81 415.943 187.857 303.682 398.552 358.075 612.335 136.529 723.674 285.687 298.028 644.049 349.039 305.292 211.985 928.915 714.347 570.713 274.173 651.426 416.947 773.107 630.173 408.266 314.921 222.129 643.245 446.719 762.041 334.29 312.312 532.556 410.755 85.4563 248.774 577.983 138.117 157.948 112.286 258.532 351.975 259.628 408.099 387.31 164.06 221.469 139.666 286.666 111.509 145.219 129.964 417.816 252.145
0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.90 0.90 0.90 0.90 0.90 0.89 0.89 0.89 0.89 0.88 0.88 0.88 0.88 0.88 0.87 0.87 0.87 0.86 0.85 0.85 0.85 0.85 0.84 0.83 0.83 0.83 0.83 0.82 0.79 0.78 0.78 0.77 0.74 0.74 0.70 0.68 0.63 2.96 1.87 1.78 1.74 1.72 1.70 1.69 1.65 1.64 1.61 1.60 1.56 1.52 1.51 1.50 1.50 1.49
1.76 0.94 1.28 1.17 1.63 1.42 0.94 0.83 0.29 1.05 1.32 0.49 0.77 1.22 0.87 1.03 0.58 1.29 1.00 1.05 1.10 0.82 1.46 0.91 5.13 1.96 0.81 0.93 1.32 1.04 1.12 1.64 1.50 0.89 0.77 1.60 1.07 1.94 0.79 0.98 1.54 0.55 0.46 0.49 0.85 1.18 0.48 0.78 1.12 0.62 1.43 2.59 1.90 1.01 1.18 0.73 0.86 0.52 0.83 0.75 2.37 1.14
ACCEPTED MANUSCRIPT
215.471 179.189 239.846 158.319 163.584 336.646 183.47 171.994 160.468 311.074 195.784 198.612 171.835 125.332 237.27 345.184 105.416 209.918 156.449 194.595 184.94 250.148 147.198 255.868 177.604 99.9995 189.235 375.55 170.591 166.031 198.815 228.906 374.151 135.656 216.176 235.922 101.417 265.891 275.992 224.191 180.801 226.262 190.602 167.493 113.727 241.655 185.113 212.11 272.844 150.835 298.206 393.876 249.268 238.692 169.547 361.167 218.562 209.796 302.82 262.665 222.062 514.402
191.456 351.742 451.175 254.11 326.045 403.918 284.609 212.252 292.798 441.515 224.79 368.3 308.763 179.207 307.772 458.342 171.147 304.61 243.043 387.57 291.98 242.478 231.807 423.547 186.479 166.482 230.542 717.002 239.062 196.713 205.197 346.636 245.163 207.898 321.17 276.077 149.334 367.373 348.904 285.495 272.489 290.552 253.176 273.473 131.36 357.203 258.549 320.688 340.997 211.139 442.555 506.534 263.218 326.789 262.97 507.73 268.606 254.247 433.863 342.937 252.316 554.85
RI PT
150.703 181.804 284.149 168.889 219.262 239.315 196.074 139.5 195.893 272.512 155.912 249.012 205.839 122.914 210.931 322.578 138.239 206 176.586 291.247 217.846 188.444 157.417 313.864 150.543 136.617 173.11 511.682 180.764 139.504 150.788 260.466 223.019 157.68 249.186 204.373 116.664 271.478 268.125 215.581 200.766 213.439 189.139 217.291 105.124 321.821 198.316 261.657 257.414 169.938 366.18 367.798 209.67 267.749 217.775 390.811 243.771 206.888 325.953 284.96 195.498 429.568
SC
5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
M AN U
TE D
Sparcl1 Supt16h Sbsn Mrpl28 Nop14 Xpot Adam9 Slc38a10 Pdcd11 Usp8 Ppp1r10 Abcb6 Clasp1 Dnajc1 Mrps15 Emc4 Psmb5 Ociad1 Lnp Raf1 Rxra Ttc37 Slc2a4 Ap3m1 Maged1 Tnpo3 Mrps7 Rpl36a Ccdc132 Sort1 Unc45a Pcbp2 Tmx4 Thoc5 Yars2 Ints3 Cnot10 Ddx52 Ppfia1 Lsm14a Mpdu1 Eif2b4 Aldh5a1 Nek7 Stk3 Tsn Mrpl50 Srsf1 Arl2 Elac2 Gna13 Myo1b Thoc2 Cpne1 Myo18a Vps39 Eif4ebp1
ERH_MOUSE Enhancer of rudimentary homolog EXOC1_MOUSE Exocyst complex component 1 RM37_MOUSE 39S ribosomal protein L37, mitochondrial SIN3A_MOUSE Paired amphipathic helix protein Sin3a CN159_MOUSE UPF0317 protein C14orf159 homolog, mitochondrial SPRL1_MOUSE SPARC-like protein 1 SP16H_MOUSE FACT complex subunit SPT16 SBSN_MOUSE Suprabasin RM28_MOUSE 39S ribosomal protein L28, mitochondrial NOP14_MOUSE Nucleolar protein 14 XPOT_MOUSE Exportin-T ADAM9_MOUSE Disintegrin and metalloproteinase domain-containing protein 9 S38AA_MOUSE Putative sodium-coupled neutral amino acid transporter 10 RRP5_MOUSE Protein RRP5 homolog UBP8_MOUSE Ubiquitin carboxyl-terminal hydrolase 8 PP1RA_MOUSE Serine/threonine-protein phosphatase 1 regulatory subunit 10 ABCB6_MOUSE ATP-binding cassette sub-family B member 6, mitochondrial CLAP1_MOUSE CLIP-associating protein 1 DNJC1_MOUSE DnaJ homolog subfamily C member 1 RT15_MOUSE 28S ribosomal protein S15, mitochondrial EMC4_MOUSE ER membrane protein complex subunit 4 PSB5_MOUSE Proteasome subunit beta type-5 OCAD1_MOUSE OCIA domain-containing protein 1 LNP_MOUSE Protein lunapark RAF1_MOUSE RAF proto-oncogene serine/threonine-protein kinase RXRA_MOUSE Retinoic acid receptor RXR-alpha F8VPK0_MOUSE Protein Ttc37 GTR4_MOUSE Solute carrier family 2, facilitated glucose transporter member 4 AP3M1_MOUSE AP-3 complex subunit mu-1 MAGD1_MOUSE Melanoma-associated antigen D1 TNPO3_MOUSE Transportin-3 RT07_MOUSE 28S ribosomal protein S7, mitochondrial RL36A_MOUSE 60S ribosomal protein L36a CC132_MOUSE Coiled-coil domain-containing protein 132 SORT_MOUSE Sortilin UN45A_MOUSE Protein unc-45 homolog A PCBP2_MOUSE Poly(rC)-binding protein 2 TMX4_MOUSE Thioredoxin-related transmembrane protein 4 THOC5_MOUSE THO complex subunit 5 homolog SYYM_MOUSE Tyrosine--tRNA ligase, mitochondrial INT3_MOUSE Integrator complex subunit 3 CNO10_MOUSE CCR4-NOT transcription complex subunit 10 DDX52_MOUSE Probable ATP-dependent RNA helicase DDX52 B2RXQ2_MOUSE Ppfia1 protein LS14A_MOUSE Protein LSM14 homolog A MPU1_MOUSE Mannose-P-dolichol utilization defect 1 protein EI2BD_MOUSE Translation initiation factor eIF-2B subunit delta SSDH_MOUSE Succinate-semialdehyde dehydrogenase, mitochondrial NEK7_MOUSE Serine/threonine-protein kinase Nek7 STK3_MOUSE Serine/threonine-protein kinase 3 TSN_MOUSE Translin RM50_MOUSE 39S ribosomal protein L50, mitochondrial SRSF1_MOUSE Serine/arginine-rich splicing factor 1 ARL2_MOUSE ADP-ribosylation factor-like protein 2 RNZ2_MOUSE Zinc phosphodiesterase ELAC protein 2 GNA13_MOUSE Guanine nucleotide-binding protein subunit alpha-13 MYO1B_MOUSE Unconventional myosin-Ib THOC2_MOUSE THO complex subunit 2 CPNE1_MOUSE Copine-1 MY18A_MOUSE Unconventional myosin-XVIIIa VPS39_MOUSE Vam6/Vps39-like protein 4EBP1_MOUSE Eukaryotic translation initiation factor 4E-binding protein 1
EP
Erh Exoc1 Mrpl37 Sin3a
AC C
sp|P84089|ERH_MOUSE sp|Q8R3S6|EXOC1_MOUSE sp|Q921S7|RM37_MOUSE sp|Q60520|SIN3A_MOUSE sp|Q8BH86|CN159_MOUSE sp|P70663|SPRL1_MOUSE sp|Q920B9|SP16H_MOUSE sp|Q8CIT9|SBSN_MOUSE sp|Q9D1B9|RM28_MOUSE sp|Q8R3N1|NOP14_MOUSE sp|Q9CRT8|XPOT_MOUSE sp|Q61072|ADAM9_MOUSE sp|Q5I012|S38AA_MOUSE sp|Q6NS46|RRP5_MOUSE sp|Q80U87|UBP8_MOUSE sp|Q80W00|PP1RA_MOUSE sp|Q9DC29|ABCB6_MOUSE sp|Q80TV8|CLAP1_MOUSE sp|Q61712|DNJC1_MOUSE sp|Q9DC71|RT15_MOUSE sp|Q9CZX9|EMC4_MOUSE sp|O55234|PSB5_MOUSE sp|Q9CRD0|OCAD1_MOUSE sp|Q7TQ95|LNP_MOUSE sp|Q99N57|RAF1_MOUSE sp|P28700|RXRA_MOUSE tr|F8VPK0|F8VPK0_MOUSE sp|P14142|GTR4_MOUSE sp|Q9JKC8|AP3M1_MOUSE sp|Q9QYH6|MAGD1_MOUSE sp|Q6P2B1|TNPO3_MOUSE sp|Q80X85|RT07_MOUSE sp|P83882|RL36A_MOUSE sp|Q8CI71|CC132_MOUSE sp|Q6PHU5|SORT_MOUSE sp|Q99KD5|UN45A_MOUSE sp|Q61990|PCBP2_MOUSE sp|Q8C0L0|TMX4_MOUSE sp|Q8BKT7|THOC5_MOUSE sp|Q8BYL4|SYYM_MOUSE sp|Q7TPD0|INT3_MOUSE sp|Q8BH15|CNO10_MOUSE sp|Q8K301|DDX52_MOUSE tr|B2RXQ2|B2RXQ2_MOUSE sp|Q8K2F8|LS14A_MOUSE sp|Q9R0Q9|MPU1_MOUSE sp|Q61749|EI2BD_MOUSE sp|Q8BWF0|SSDH_MOUSE sp|Q9ES74|NEK7_MOUSE sp|Q9JI10|STK3_MOUSE sp|Q62348|TSN_MOUSE sp|Q8VDT9|RM50_MOUSE sp|Q6PDM2|SRSF1_MOUSE sp|Q9D0J4|ARL2_MOUSE sp|Q80Y81|RNZ2_MOUSE sp|P27601|GNA13_MOUSE sp|P46735|MYO1B_MOUSE sp|B1AZI6|THOC2_MOUSE sp|Q8C166|CPNE1_MOUSE sp|Q9JMH9|MY18A_MOUSE sp|Q8R5L3|VPS39_MOUSE sp|Q60876|4EBP1_MOUSE
354.708 183.203 322.382 216.149 221.268 418.712 252.303 225.571 206.945 374.596 259.239 242.964 206.056 154.477 288.186 423.567 150.635 239.845 190.4 243.002 227.689 319.182 157.24 303.906 228.329 131.777 225.598 392.846 200.27 184.254 229.608 260.378 493.801 154.869 251.156 265.332 117.278 289.128 315.642 251.22 192.862 242.13 206.667 192.289 132.646 322.423 203.568 246.927 292.673 171.366 347.196 397.572 277.97 267.411 190.461 372.524 271.656 231.845 296.979 292.982 231.905 534.966
571.577 332.014 153.2 305.371 282.786 40.1059 161.73 209.838 155.257 453.722 461.497 177.879 86.6857 209.365 359.952 390.344 243.218 248.927 155.097 151.479 237.7 285.171 155.063 276.476 142.148 636.983 348.613 496.651 169.037 121.054 312.454 166.886 254.33 140.565 220.311 314.678 419.753 224.584 318.655 215.694 225.254 291.967 249.332 237.485 218.354 493.305 407.728 152.995 263.446 149.991 359.69 147.567 185.475 241.512 198.577 646.558 418.404 202.654 426.616 148.108 246.148 157.357
1205.88 391.223 199.582 505.066 441.125 218.997 170.593 365.157 241.216 469.585 306.289 124.891 189.553 94.4014 395.395 877.62 136.767 254.666 346.168 199.362 316.464 245.72 170.451 324.3 131.63 551.977 230.658 260.5 130.342 269.546 221.224 398.704 530.073 109.666 214.392 290.988 679.345 201.435 162.679 278.545 190.981 208.71 257.456 305.359 495.803 827.429 179.653 288.926 289.883 202.587 223.699 453.349 473.087 484.795 168.402 487.974 390.735 224.705 542.898 211.412 193.176 241.142
1.49 1.48 1.48 1.44 1.43 1.43 1.41 1.41 1.40 1.40 1.38 1.37 1.36 1.34 1.33 1.32 1.32 1.31 1.30 1.30 1.29 1.28 1.28 1.28 1.26 1.26 1.26 1.25 1.25 1.25 1.24 1.24 1.24 1.24 1.23 1.23 1.22 1.22 1.22 1.22 1.22 1.21 1.21 1.21 1.21 1.21 1.21 1.20 1.20 1.19 1.19 1.19 1.18 1.17 1.17 1.17 1.17 1.17 1.16 1.16 1.16 1.15
4.85 2.00 0.67 2.48 1.89 0.45 0.88 1.85 1.11 1.58 2.18 0.68 0.73 1.22 1.69 1.90 1.56 1.21 1.51 0.72 1.38 1.21 1.07 1.05 0.83 5.02 1.60 0.85 0.85 1.28 1.53 1.16 1.31 0.85 0.93 1.38 5.04 0.79 0.88 1.12 1.09 1.14 1.33 1.41 3.26 2.34 1.53 0.93 1.04 1.10 0.88 0.79 1.43 1.43 0.95 1.51 1.75 1.03 1.54 0.66 1.05 0.42
ACCEPTED MANUSCRIPT
TE D
EP
311.937 179.6 302.929 210.939 129.277 306.194 274.876 304.894 284.408 235.127 177.563 156.172 230.015 168.961 220.262 186.63 370.958 304.739 235.559 249.052 392.149 266.672 240.914 352.707 337.445 233.963 143.94 273.684 282.943 299.204 148.64 175.509 165.38 218.114 198.761 325.81 212.582 207.053 283.248 147.388 238.341 276.67 170.236 251.969 261.594 223.08 306.583 190.386 242.462 337.688 292.474 344.481 179.816 280.421 396.811 376.542 275.892 178.732 273.626 150.81 277.457 264.1
423.493 211.723 479.132 473.154 182.695 428.316 377.38 355.928 410.544 337.913 226.439 227.155 279.828 218.539 283.881 264.714 456.962 322.86 299.395 310.723 470.202 294.266 303.26 417.626 600.587 260.833 187.098 281.916 336.965 174.809 190.78 223.293 251.157 290.074 230.757 405.397 239.327 238.391 260.135 174.892 198.115 345.339 207.08 241.749 327.784 253.161 266.096 259.081 325.912 373.341 282.06 413.901 170.078 336.496 473.546 400.034 336.147 224.017 258.627 162.565 311.531 259.905
RI PT
361.093 179.229 406.144 379.031 147.002 357.387 312.85 302.475 364.852 301.746 191.774 197.945 234.259 193.765 242.291 219.915 371.021 288.051 258.594 277.045 410.096 237.387 254.672 346.925 513.539 205.939 166.309 255.519 307.813 272.553 165.575 209.617 226.044 269.244 209.072 363.509 217.334 223.964 208.119 153.877 143.293 320.492 165.08 239.871 324.534 231.85 211.363 228.575 297.913 344.827 296.049 337.195 181.908 380.588 445.904 343.994 313.452 195.261 288.35 154.435 296.656 282.043
SC
5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
M AN U
Ralgapb RLGPB_MOUSE Ral GTPase-activating protein subunit beta Mtor MTOR_MOUSE Serine/threonine-protein kinase mTOR Wdr91 WDR91_MOUSE WD repeat-containing protein 91 Gyg1 GLYG_MOUSE Glycogenin-1 Nhp2 NHP2_MOUSE H/ACA ribonucleoprotein complex subunit 2 Rnmtl1 RMTL1_MOUSE RNA methyltransferase-like protein 1 Nfia NFIA_MOUSE Nuclear factor 1 A-type Mapkapk2 MAPK2_MOUSE MAP kinase-activated protein kinase 2 Ampd2 AMPD2_MOUSE AMP deaminase 2 Mrps26 RT26_MOUSE 28S ribosomal protein S26, mitochondrial Sltm SLTM_MOUSE SAFB-like transcription modulator Rps6kb1 KS6B1_MOUSE Ribosomal protein S6 kinase beta-1 Lyplal1 LYPL1_MOUSE Lysophospholipase-like protein 1 Celf1 CELF1_MOUSE CUGBP Elav-like family member 1 Lrrc40 LRC40_MOUSE Leucine-rich repeat-containing protein 40 Osbpl11 OSB11_MOUSE Oxysterol-binding protein-related protein 11 Gnptab GNPTA_MOUSE N-acetylglucosamine-1-phosphotransferase subunits alpha/beta Mrpl9 RM09_MOUSE 39S ribosomal protein L9, mitochondrial Herc4 HERC4_MOUSE Probable E3 ubiquitin-protein ligase HERC4 Mrpl19 RM19_MOUSE 39S ribosomal protein L19, mitochondrial Mob1b MOB1B_MOUSE MOB kinase activator 1B 1810009A15RikQ9D937_MOUSE MCG127334 Tsg101 TS101_MOUSE Tumor susceptibility gene 101 protein Cog4 COG4_MOUSE Conserved oligomeric Golgi complex subunit 4 Insr INSR_MOUSE Insulin receptor Ppp1r2 IPP2_MOUSE Protein phosphatase inhibitor 2 Gsk3b GSK3B_MOUSE Glycogen synthase kinase-3 beta CA123_MOUSE UPF0587 protein C1orf123 homolog Trappc12 TPC12_MOUSE Trafficking protein particle complex subunit 12 Slc25a11 M2OM_MOUSE Mitochondrial 2-oxoglutarate/malate carrier protein Bre BRE_MOUSE BRCA1-A complex subunit BRE Spg21 SPG21_MOUSE Maspardin Timm21 TIM21_MOUSE Isoform 2 of Mitochondrial import inner membrane translocase subunit Tim21 Lman2l LMA2L_MOUSE VIP36-like protein Inppl1 SHIP2_MOUSE Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Preb PREB_MOUSE Prolactin regulatory element-binding protein Ufl1 UFL1_MOUSE E3 UFM1-protein ligase 1 Osbpl2 OSBL2_MOUSE Oxysterol-binding protein-related protein 2 Serbp1 PAIRB_MOUSE Isoform 2 of Plasminogen activator inhibitor 1 RNA-binding protein Cnpy4 CNPY4_MOUSE Protein canopy homolog 4 Dnajb1 DNJB1_MOUSE DnaJ homolog subfamily B member 1 Cog7 COG7_MOUSE Conserved oligomeric Golgi complex subunit 7 Cisd3 CISD3_MOUSE CDGSH iron-sulfur domain-containing protein 3, mitochondrial Nolc1 E9Q5C9_MOUSE Protein Nolc1 Acap2 ACAP2_MOUSE Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 Ict1 ICT1_MOUSE Peptidyl-tRNA hydrolase ICT1, mitochondrial Ptms PTMS_MOUSE Parathymosin Ehd4 EHD4_MOUSE EH domain-containing protein 4 Phf3 B2RQG2_MOUSE PHD finger protein 3 Ptpn1 PTN1_MOUSE Tyrosine-protein phosphatase non-receptor type 1 Ankfy1 ANFY1_MOUSE Ankyrin repeat and FYVE domain-containing protein 1 Gpr107 GP107_MOUSE Protein GPR107 Rpia RPIA_MOUSE Ribose-5-phosphate isomerase Mrpl47 RM47_MOUSE 39S ribosomal protein L47, mitochondrial Tmem126b T126B_MOUSE Complex I assembly factor TMEM126B, mitochondrial Gigyf2 PERQ2_MOUSE PERQ amino acid-rich with GYF domain-containing protein 2 Ndufaf1 CIA30_MOUSE Complex I intermediate-associated protein 30, mitochondrial Optn OPTN_MOUSE Optineurin Smarca4 SMCA4_MOUSE Transcription activator BRG1 Hnrnph2 HNRH2_MOUSE Heterogeneous nuclear ribonucleoprotein H2 Ube2o UBE2O_MOUSE Ubiquitin-conjugating enzyme E2 O Stag2 STAG2_MOUSE Cohesin subunit SA-2
AC C
sp|Q8BQZ4|RLGPB_MOUSE sp|Q9JLN9|MTOR_MOUSE sp|Q7TMQ7|WDR91_MOUSE sp|Q9R062|GLYG_MOUSE sp|Q9CRB2|NHP2_MOUSE sp|Q5ND52|RMTL1_MOUSE sp|Q02780|NFIA_MOUSE sp|P49138|MAPK2_MOUSE sp|Q9DBT5|AMPD2_MOUSE sp|Q80ZS3|RT26_MOUSE sp|Q8CH25|SLTM_MOUSE sp|Q8BSK8|KS6B1_MOUSE sp|Q3UFF7|LYPL1_MOUSE sp|P28659|CELF1_MOUSE sp|Q9CRC8|LRC40_MOUSE sp|Q8CI95|OSB11_MOUSE sp|Q69ZN6|GNPTA_MOUSE sp|Q99N94|RM09_MOUSE sp|Q6PAV2|HERC4_MOUSE sp|Q9D338|RM19_MOUSE sp|Q8BPB0|MOB1B_MOUSE tr|Q9D937|Q9D937_MOUSE sp|Q61187|TS101_MOUSE sp|Q8R1U1|COG4_MOUSE sp|P15208|INSR_MOUSE sp|Q9DCL8|IPP2_MOUSE sp|Q9WV60|GSK3B_MOUSE sp|Q8BHG2|CA123_MOUSE sp|Q8K2L8|TPC12_MOUSE sp|Q9CR62|M2OM_MOUSE sp|Q8K3W0|BRE_MOUSE sp|Q9CQC8|SPG21_MOUSE sp|Q8CCM6-2|TIM21_MOUSE sp|P59481|LMA2L_MOUSE sp|Q6P549|SHIP2_MOUSE sp|Q9WUQ2|PREB_MOUSE sp|Q8CCJ3|UFL1_MOUSE sp|Q8BX94|OSBL2_MOUSE sp|Q9CY58-2|PAIRB_MOUSE sp|Q8BQ47|CNPY4_MOUSE sp|Q9QYJ3|DNJB1_MOUSE sp|Q3UM29|COG7_MOUSE sp|B1AR13|CISD3_MOUSE tr|E9Q5C9|E9Q5C9_MOUSE sp|Q6ZQK5|ACAP2_MOUSE sp|Q8R035|ICT1_MOUSE sp|Q9D0J8|PTMS_MOUSE sp|Q9EQP2|EHD4_MOUSE tr|B2RQG2|B2RQG2_MOUSE sp|P35821|PTN1_MOUSE sp|Q810B6|ANFY1_MOUSE sp|Q8BUV8|GP107_MOUSE sp|P47968|RPIA_MOUSE sp|Q8K2Y7|RM47_MOUSE sp|Q9D1R1|T126B_MOUSE sp|Q6Y7W8|PERQ2_MOUSE sp|Q9CWX2|CIA30_MOUSE sp|Q8K3K8|OPTN_MOUSE sp|Q3TKT4|SMCA4_MOUSE sp|P70333|HNRH2_MOUSE sp|Q6ZPJ3|UBE2O_MOUSE sp|O35638|STAG2_MOUSE
349.981 199.433 332.193 199.558 131.142 325.394 289.261 330.896 319.338 264.08 187.444 168.824 238.37 183.904 228.832 185.904 364.585 332.861 246.967 270.19 415.406 261.919 243.159 353.218 336.644 220.147 151.669 294.091 304.203 445.695 150.136 194.254 172.752 236.543 209.85 338.911 224.68 226.669 269.702 149.613 212.714 297.485 152.417 284.981 299.482 232.319 286.001 186.686 246.446 348.632 340.43 305.135 211.315 357.298 409.481 353.643 279.822 166.728 326.472 154.56 284.59 305.166
264.909 267.617 297.521 248.248 388.486 86.7108 275.716 271.297 340.345 132.728 174.263 190.204 162.386 328.514 252.162 209.347 286.02 132.222 244.61 283.362 477.007 196.069 216.688 464.838 395.821 130.442 173.416 245.83 241.47 306.571 304.976 176.797 226.198 209.017 267.059 482.325 213.726 242.018 204.472 164.018 307.505 266.159 240.608 232.835 239.655 157.409 150.464 231.601 261.56 380.635 532.312 352.163 108.105 128.063 239.107 249.954 149.824 149.872 350.101 346.333 348.013 239.152
324.368 223.708 315.948 641.594 420.293 357.004 338.259 294.064 265.708 207.425 314.763 223.792 241.185 374.326 233.573 257.64 527.947 346.406 238.464 344.799 461.252 331.797 250.171 291.516 350.823 334.844 162.698 584.61 312.948 259.241 259.278 155.368 145.422 209.597 382.668 328.198 152.791 242.373 443.414 228.306 409.88 227.86 329.51 322.116 228.056 419.341 820.835 239.613 456.685 583.594 691.937 331.774 116.8 317.863 276.341 602.051 355.416 275.14 362.469 510.401 339.225 170.869
1.15 1.15 1.14 1.14 1.14 1.14 1.13 1.13 1.12 1.12 1.12 1.12 1.12 1.11 1.11 1.11 1.11 1.11 1.11 1.10 1.10 1.10 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.03
0.88 1.37 0.87 1.51 2.93 0.67 1.04 0.93 0.93 0.63 1.32 1.17 0.87 1.94 1.05 1.15 1.10 0.81 0.98 1.19 1.17 1.05 0.94 1.08 0.88 1.06 1.08 1.57 0.94 0.99 1.80 0.86 0.95 0.86 1.59 1.18 0.85 1.12 1.32 1.30 1.88 0.83 1.70 1.13 0.80 1.27 1.88 1.12 1.33 1.41 2.08 1.00 0.62 0.67 0.61 1.18 0.86 1.14 1.27 2.81 1.20 0.75
ACCEPTED MANUSCRIPT
TE D
218.775 257.996 186.786 271.395 347.372 273.919 216.62 304.337 181.646 401.523 325.083 381.648 233.646 218.22 343.621 163.158 297.73 293.476 255.148 141.65 391.078 159.631 218.268 180.582 237.217 274.721 220.736 194.836 375.807 261.806 369.711 257.606 184.052 205.697 364.627 134.283 358.609 417.043 231.133 321.054 95.9821 430.546 187.041 413.462 297.4 166.392 240.383 312.741 204.711 237.201 265.603 208.362 333.043 261.242 182.458 234.392 215.885 389.303 202.329 176.126 115.584 649.668
260.377 265.922 206.443 297.764 372.662 334.886 198.257 380.688 177.407 338.947 312.002 369.09 255.147 261.467 371.173 225.228 300.22 310.568 339.23 149.68 492.787 192.826 268.607 226.439 248.638 245.663 215.552 213.52 415.238 329.73 431.13 262.434 202.814 215.569 416.942 131.104 431.953 467.234 219.928 337.121 93.5175 489.318 189.512 435.31 293.924 194.698 294.033 302.956 221.902 207.755 344.357 214.16 318.978 268.79 189.464 227.287 210.835 445.959 222.275 225.602 109.771 602.651
RI PT
236.876 228.439 200.217 297.361 332.51 317.868 232.009 353.356 192.609 344.399 336.904 329.872 212.878 272.256 362.893 201.139 261.27 284.234 347.728 133.967 454.651 167.009 230.757 261.723 213.973 280.252 190.54 210.111 345.984 344.986 404.755 233.234 237.759 198.514 401.978 110.311 394.523 462.392 202.471 333.176 100.337 499.032 197.774 419.2 260.25 223.134 291.526 311.844 205.051 227.059 344.48 232.202 283.622 290.369 193.215 262.993 183.826 407.947 249.749 224.299 124.365 547.096
SC
5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
M AN U
NISCH_MOUSE Nischarin PARVA_MOUSE Alpha-parvin E9QAS7_MOUSE Protein Inpp5a TGBR3_MOUSE Transforming growth factor beta receptor type 3 E9Q3E1_MOUSE Aldehyde dehydrogenase MTMR1_MOUSE Myotubularin-related protein 1 OFUT2_MOUSE GDP-fucose protein O-fucosyltransferase 2 STX8_MOUSE Syntaxin-8 FXR1_MOUSE Fragile X mental retardation syndrome-related protein 1 SYPL1_MOUSE Synaptophysin-like protein 1 TMED5_MOUSE Transmembrane emp24 domain-containing protein 5 RM32_MOUSE 39S ribosomal protein L32, mitochondrial HRSL3_MOUSE HRAS-like suppressor 3 AKT1_MOUSE RAC-alpha serine/threonine-protein kinase ZN598_MOUSE Zinc finger protein 598 RAB3A_MOUSE Ras-related protein Rab-3A LRRF2_MOUSE Leucine-rich repeat flightless-interacting protein 2 SHC1_MOUSE SHC-transforming protein 1 ASGL1_MOUSE Isoaspartyl peptidase/L-asparaginase MED21_MOUSE Mediator of RNA polymerase II transcription subunit 21 UCK1_MOUSE Uridine-cytidine kinase 1 RPRD2_MOUSE Regulation of nuclear pre-mRNA domain-containing protein 2 DCXR_MOUSE L-xylulose reductase NAKD2_MOUSE NAD kinase 2, mitochondrial DJC24_MOUSE DnaJ homolog subfamily C member 24 PI3R4_MOUSE Phosphoinositide 3-kinase regulatory subunit 4 D3Z285_MOUSE NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (Fragment) SUOX_MOUSE Sulfite oxidase, mitochondrial A2AR76_MOUSE TRAF family member-associated NF-kappa-B activator SNX4_MOUSE Sorting nexin-4 RNT2_MOUSE Ribonuclease T2 TRIP4_MOUSE Activating signal cointegrator 1 RBM22_MOUSE Pre-mRNA-splicing factor RBM22 E9PWM3_MOUSE Protein Armcx4 MOCS1_MOUSE Molybdenum cofactor biosynthesis protein 1 SORCN_MOUSE Sorcin COMD1_MOUSE COMM domain-containing protein 1 NMRL1_MOUSE NmrA-like family domain-containing protein 1 PEA15_MOUSE Astrocytic phosphoprotein PEA-15 CHERP_MOUSE Calcium homeostasis endoplasmic reticulum protein PEG10_MOUSE Retrotransposon-derived protein PEG10 ADH1_MOUSE Alcohol dehydrogenase 1 COG2_MOUSE Conserved oligomeric Golgi complex subunit 2 SPF45_MOUSE Splicing factor 45 CSTF2_MOUSE Cleavage stimulation factor subunit 2 CAF17_MOUSE Putative transferase CAF17 homolog, mitochondrial CECR5_MOUSE Cat eye syndrome critical region protein 5 homolog LSG1_MOUSE Large subunit GTPase 1 homolog SASH1_MOUSE SAM and SH3 domain-containing protein 1 OTUB1_MOUSE Ubiquitin thioesterase OTUB1 ATPF2_MOUSE ATP synthase mitochondrial F1 complex assembly factor 2 UIF_MOUSE UAP56-interacting factor HEM4_MOUSE Uroporphyrinogen-III synthase RBNS5_MOUSE Rabenosyn-5 BABA1_MOUSE BRISC and BRCA1-A complex member 1 CPT1A_MOUSE Carnitine O-palmitoyltransferase 1, liver isoform ATF2_MOUSE Cyclic AMP-dependent transcription factor ATF-2 ENPP5_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 KBP_MOUSE KIF1-binding protein PRP31_MOUSE U4/U6 small nuclear ribonucleoprotein Prp31 PP1B_MOUSE Serine/threonine-protein phosphatase PP1-beta catalytic subunit CPIN1_MOUSE Anamorsin
EP
Nisch Parva Inpp5a Tgfbr3 Aldh3b2 Mtmr1 Pofut2 Stx8 Fxr1 Sypl1 Tmed5 Mrpl32 Pla2g16 Akt1 Znf598 Rab3a Lrrfip2 Shc1 Asrgl1 Med21 Uck1 Rprd2 Dcxr Nadk2 Dnajc24 Pik3r4 Nfu1 Suox Tank Snx4 Rnaset2 Trip4 Rbm22 Armcx4 Mocs1 Sri Commd1 Nmral1 Pea15 Cherp Peg10 Adh1 Cog2 Rbm17 Cstf2 Iba57 Cecr5 Lsg1 Sash1 Otub1 Atpaf2 Fyttd1 Uros Zfyve20 Babam1 Cpt1a Atf2 Enpp5 Kbp Prpf31 Ppp1cb Ciapin1
AC C
sp|Q80TM9|NISCH_MOUSE sp|Q9EPC1|PARVA_MOUSE tr|E9QAS7|E9QAS7_MOUSE sp|O88393|TGBR3_MOUSE tr|E9Q3E1|E9Q3E1_MOUSE sp|Q9Z2C4|MTMR1_MOUSE sp|Q8VHI3|OFUT2_MOUSE sp|O88983|STX8_MOUSE sp|Q61584|FXR1_MOUSE sp|O09117|SYPL1_MOUSE sp|Q9CXE7|TMED5_MOUSE sp|Q9DCI9|RM32_MOUSE sp|Q8R3U1|HRSL3_MOUSE sp|P31750|AKT1_MOUSE sp|Q80YR4|ZN598_MOUSE sp|P63011|RAB3A_MOUSE sp|Q91WK0|LRRF2_MOUSE sp|P98083|SHC1_MOUSE sp|Q8C0M9|ASGL1_MOUSE sp|Q9CQ39|MED21_MOUSE sp|P52623|UCK1_MOUSE sp|Q6NXI6|RPRD2_MOUSE sp|Q91X52|DCXR_MOUSE sp|Q8C5H8|NAKD2_MOUSE sp|Q91ZF0|DJC24_MOUSE sp|Q8VD65|PI3R4_MOUSE tr|D3Z285|D3Z285_MOUSE sp|Q8R086|SUOX_MOUSE tr|A2AR76|A2AR76_MOUSE sp|Q91YJ2|SNX4_MOUSE sp|Q9CQ01|RNT2_MOUSE sp|Q9QXN3|TRIP4_MOUSE sp|Q8BHS3|RBM22_MOUSE tr|E9PWM3|E9PWM3_MOUSE sp|Q5RKZ7|MOCS1_MOUSE sp|Q6P069|SORCN_MOUSE sp|Q8K4M5|COMD1_MOUSE sp|Q8K2T1|NMRL1_MOUSE sp|Q62048|PEA15_MOUSE sp|Q8CGZ0|CHERP_MOUSE sp|Q7TN75|PEG10_MOUSE sp|P00329|ADH1_MOUSE sp|Q921L5|COG2_MOUSE sp|Q8JZX4|SPF45_MOUSE sp|Q8BIQ5|CSTF2_MOUSE sp|Q8CAK1|CAF17_MOUSE sp|Q91WM2|CECR5_MOUSE sp|Q3UM18|LSG1_MOUSE sp|P59808|SASH1_MOUSE sp|Q7TQI3|OTUB1_MOUSE sp|Q91YY4|ATPF2_MOUSE sp|Q91Z49|UIF_MOUSE sp|P51163|HEM4_MOUSE sp|Q80Y56|RBNS5_MOUSE sp|Q3UI43|BABA1_MOUSE sp|P97742|CPT1A_MOUSE sp|P16951|ATF2_MOUSE sp|Q9EQG7|ENPP5_MOUSE sp|Q6ZPU9|KBP_MOUSE sp|Q8CCF0|PRP31_MOUSE sp|P62141|PP1B_MOUSE sp|Q8WTY4|CPIN1_MOUSE
210.754 236.246 191.085 286.262 324.841 272.138 261.345 289.749 203.777 420.269 360.096 352.843 196.763 233.822 341.657 141.565 261.625 266.664 261.7 124.917 348.751 131.718 176.585 211.146 196.325 301.393 189.649 184.935 294.143 266.102 328.956 219.229 210.718 180.423 333.288 107.682 302.928 390.414 200.489 296.13 96.2373 408.217 181.83 368.018 242.786 179.746 217.278 297.032 171.336 236.981 238.456 206.456 269.443 257.264 167.302 244.386 167.395 306.567 203.977 151.556 114.93 512.563
500.94 251.406 183.544 230.631 279.324 196.892 248.61 180.07 381.679 398.679 437.462 206.586 166.693 230.386 328.671 422.119 259.87 300.921 222.519 83.1185 284.394 198.077 213.422 259.014 310.472 392.936 212.964 159.368 205.495 303.176 252.141 241.748 284.45 145.316 239.674 765.366 356.173 323.711 131.494 400.453 867.703 250.613 238.049 469.651 270.237 169.373 262.607 335.252 161.777 199.762 240.931 80.8261 194.79 339.401 386.333 297.44 138.319 282.811 220.348 226.562 245.565 561.52
449.687 238.932 165.958 298.182 358.706 224.015 171.287 233.404 342.985 318.213 439.094 652.631 407.241 276.705 449.877 428.232 582.614 658.333 364.701 238.733 323.826 210.746 271.022 248.058 782.463 360.324 470.365 339.753 508.916 273.596 597.913 578.976 342.668 312.392 361.109 1162.26 407.476 486.56 232.281 661.128 336.495 329.949 257.057 1008.66 535.027 176.566 528.058 373.15 307.221 180.756 307.875 195.026 430.619 404.398 441.925 182.896 250.919 373.042 221.308 192.932 264.439 1104.49
1.03 1.03 1.03 1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.95 0.95 0.94 0.94 0.94 0.94 0.93
2.09 1.01 0.90 0.93 0.94 0.71 0.94 0.63 1.94 0.96 1.32 1.21 1.29 1.03 1.10 2.33 1.51 1.66 0.97 1.17 0.72 1.25 1.08 1.15 2.42 1.36 1.66 1.23 0.99 0.95 1.10 1.67 1.49 1.13 0.78 7.88 1.01 0.92 0.84 1.62 6.13 0.62 1.29 1.78 1.44 0.89 1.49 1.13 1.14 0.82 0.90 0.63 1.01 1.35 2.20 0.97 0.97 0.82 0.98 1.05 2.13 1.39
ACCEPTED MANUSCRIPT
177.942 327.024 313.766 224.997 293.764 249.133 248.038 431.269 330.055 273.085 183.59 224.659 125.804 321.566 301.972 447.331 315.793 283.125 279.185 251.341 170.386 197.644 246.223 297.629 233.689 234.334 247.833 333.923 276.696 277.289 285.39 283.689 227.77 495.137 203.468 446.755 139.961 163.57 347.843 142.005 137.223 236.406 379.293 222.256 278.136 398.63 310.031 348.942 89.6253 0.00998063 54.9463 115.39 154.144 105.355 135.995 227.098 88.7742 164.395 262.331 151.707 133.226 100.958
156.066 337.418 265.312 224.394 270.452 246.122 251.037 344.709 253.664 261.591 174.223 209.875 117.658 336.927 211.922 436.639 294.939 281.298 271.46 236.709 144.656 152.201 225.774 259.974 242.128 183.673 193.045 315.846 219.57 263.257 253.779 261.792 237.715 505.128 172.097 414.164 145.692 153.675 262.02 117.083 139.292 202.075 315.374 206.87 263.299 302.563 232.233 206.435 573.255 8.4784 196.113 318.029 449.192 221.167 296.752 364.599 244.728 411.916 364.546 226.39 237.41 211.951
RI PT
177.336 366.859 290.816 265.17 293.782 240.587 225.376 344.806 248.106 284.81 238.131 196.055 103.811 357.828 203.436 501.183 326.259 320.629 327.414 248.94 139.219 227.272 264.272 339.521 264.004 195.48 220.823 311.401 202.844 305.48 261.321 251.144 321.976 568.27 166.327 460.141 169.156 183.129 292.792 162.018 163.364 266.083 378.885 258.431 337.401 545.97 415.825 384.758 80.1184 3.06685 84.9684 144.469 188.499 118.413 81.2039 171.271 140.793 181.995 231.032 163.458 157.803 123.61
SC
5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 4 4 4 4 4 4 4 4 4 4 4 4 4 4
M AN U
TE D
Ndrg1 Mat2b Cltb Tardbp Ccdc25 Tmcc3 Strip1 Vps4a Sf3b4 Kiaa0196 Capza1 Gna11 Sh3bp1 Lrrfip1 Ftl1 Cd99l2 Dnajb4 Fggy Lxn Dnajb9 Prcp Nid1 Gpatch8 Cdkn2c Cbwd1 Bag1 Tjp2 Ppp2cb Tsc22d3 Purb Prkab2 Gpt2 Papola Prpf38b Manba Impa2 Ca2 Cnbp Ptn Akr1c14 Naalad2 Dclk1 Ndufa12 Apoc1 Clec2d Mrps18a Tmem87a Pfkfb1 Fads1 Plgrkt
DCAF8_MOUSE DDB1- and CUL4-associated factor 8 UBCP1_MOUSE Ubiquitin-like domain-containing CTD phosphatase 1 HEXI1_MOUSE Protein HEXIM1 KIF2A_MOUSE Kinesin-like protein KIF2A TGON1_MOUSE Trans-Golgi network integral membrane protein 1 MFR1L_MOUSE Mitochondrial fission regulator 1-like CRK_MOUSE Adapter molecule crk TAXB1_MOUSE Tax1-binding protein 1 homolog DNJB6_MOUSE Isoform B of DnaJ homolog subfamily B member 6 LTOR3_MOUSE Ragulator complex protein LAMTOR3 MCAT_MOUSE Mitochondrial carnitine/acylcarnitine carrier protein CI078_MOUSE Uncharacterized protein C9orf78 homolog NDRG1_MOUSE Protein NDRG1 MAT2B_MOUSE Methionine adenosyltransferase 2 subunit beta CLCB_MOUSE Isoform 2 of Clathrin light chain B TADBP_MOUSE TAR DNA-binding protein 43 CCD25_MOUSE Coiled-coil domain-containing protein 25 TMCC3_MOUSE Transmembrane and coiled-coil domains protein 3 STRP1_MOUSE Striatin-interacting protein 1 VPS4A_MOUSE Vacuolar protein sorting-associated protein 4A SF3B4_MOUSE Splicing factor 3B subunit 4 STRUM_MOUSE WASH complex subunit strumpellin Q5RKN9_MOUSE Capping protein (Actin filament) muscle Z-line, alpha 1 GNA11_MOUSE Guanine nucleotide-binding protein subunit alpha-11 3BP1_MOUSE SH3 domain-binding protein 1 LRRF1_MOUSE Leucine-rich repeat flightless-interacting protein 1 Q9CPX4_MOUSE Ferritin C99L2_MOUSE CD99 antigen-like protein 2 DNJB4_MOUSE DnaJ homolog subfamily B member 4 FGGY_MOUSE FGGY carbohydrate kinase domain-containing protein LXN_MOUSE Latexin DNJB9_MOUSE DnaJ homolog subfamily B member 9 PCP_MOUSE Lysosomal Pro-X carboxypeptidase NID1_MOUSE Nidogen-1 GPTC8_MOUSE G patch domain-containing protein 8 CDN2C_MOUSE Cyclin-dependent kinase 4 inhibitor C CBWD1_MOUSE COBW domain-containing protein 1 BAG1_MOUSE BAG family molecular chaperone regulator 1 ZO2_MOUSE Tight junction protein ZO-2 PP2AB_MOUSE Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform T22D3_MOUSE Isoform 3 of TSC22 domain family protein 3 PURB_MOUSE Transcriptional activator protein Pur-beta AAKB2_MOUSE 5'-AMP-activated protein kinase subunit beta-2 ALAT2_MOUSE Alanine aminotransferase 2 E9QAN2_MOUSE Poly(A) polymerase alpha PR38B_MOUSE Pre-mRNA-splicing factor 38B MANBA_MOUSE Beta-mannosidase IMPA2_MOUSE Inositol monophosphatase 2 CAH2_MOUSE Carbonic anhydrase 2 CNBP_MOUSE Isoform 2 of Cellular nucleic acid-binding protein PTN_MOUSE Pleiotrophin Q91WT7_MOUSE 3-alpha-hydroxysteroid dehydrogenase type 1 NALD2_MOUSE N-acetylated-alpha-linked acidic dipeptidase 2 DCLK1_MOUSE Serine/threonine-protein kinase DCLK1 NDUAC_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 APOC1_MOUSE Apolipoprotein C-I CLC2D_MOUSE C-type lectin domain family 2 member D RT18A_MOUSE 28S ribosomal protein S18a, mitochondrial TM87A_MOUSE Transmembrane protein 87A F261_MOUSE 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 FADS1_MOUSE Fatty acid desaturase 1 PLRKT_MOUSE Plasminogen receptor (KT)
EP
Dcaf8 Ublcp1 Hexim1 Kif2a Tgoln1 Mtfr1l Crk Tax1bp1 Dnajb6 Lamtor3 Slc25a20
AC C
sp|Q8N7N5|DCAF8_MOUSE sp|Q8BGR9|UBCP1_MOUSE sp|Q8R409|HEXI1_MOUSE sp|P28740|KIF2A_MOUSE sp|Q62313|TGON1_MOUSE sp|Q9CWE0|MFR1L_MOUSE sp|Q64010|CRK_MOUSE sp|Q3UKC1|TAXB1_MOUSE sp|O54946-2|DNJB6_MOUSE sp|O88653|LTOR3_MOUSE sp|Q9Z2Z6|MCAT_MOUSE sp|Q3TQI7|CI078_MOUSE sp|Q62433|NDRG1_MOUSE sp|Q99LB6|MAT2B_MOUSE sp|Q6IRU5-2|CLCB_MOUSE sp|Q921F2|TADBP_MOUSE sp|Q78PG9|CCD25_MOUSE sp|Q8R310|TMCC3_MOUSE sp|Q8C079|STRP1_MOUSE sp|Q8VEJ9|VPS4A_MOUSE sp|Q8QZY9|SF3B4_MOUSE sp|Q8C2E7|STRUM_MOUSE tr|Q5RKN9|Q5RKN9_MOUSE sp|P21278|GNA11_MOUSE sp|P55194|3BP1_MOUSE sp|Q3UZ39|LRRF1_MOUSE tr|Q9CPX4|Q9CPX4_MOUSE sp|Q8BIF0|C99L2_MOUSE sp|Q9D832|DNJB4_MOUSE sp|A2AJL3|FGGY_MOUSE sp|P70202|LXN_MOUSE sp|Q9QYI6|DNJB9_MOUSE sp|Q7TMR0|PCP_MOUSE sp|P10493|NID1_MOUSE sp|A2A6A1|GPTC8_MOUSE sp|Q60772|CDN2C_MOUSE sp|Q8VEH6|CBWD1_MOUSE sp|Q60739|BAG1_MOUSE sp|Q9Z0U1|ZO2_MOUSE sp|P62715|PP2AB_MOUSE sp|Q9Z2S7-3|T22D3_MOUSE sp|O35295|PURB_MOUSE sp|Q6PAM0|AAKB2_MOUSE sp|Q8BGT5|ALAT2_MOUSE tr|E9QAN2|E9QAN2_MOUSE sp|Q80SY5|PR38B_MOUSE sp|Q8K2I4|MANBA_MOUSE sp|Q91UZ5|IMPA2_MOUSE sp|P00920|CAH2_MOUSE sp|P53996-2|CNBP_MOUSE sp|P63089|PTN_MOUSE tr|Q91WT7|Q91WT7_MOUSE sp|Q9CZR2|NALD2_MOUSE sp|Q9JLM8|DCLK1_MOUSE sp|Q7TMF3|NDUAC_MOUSE sp|P34928|APOC1_MOUSE sp|Q91V08|CLC2D_MOUSE sp|Q99N85|RT18A_MOUSE sp|Q8BXN9|TM87A_MOUSE sp|P70266|F261_MOUSE sp|Q920L1|FADS1_MOUSE sp|Q9D3P8|PLRKT_MOUSE
174.025 306.949 295.732 230.005 273.872 205.379 185.242 368.494 277.389 250.017 212.143 174.959 90.2002 276.28 244.158 415.454 276.005 254.714 265.299 205.517 128.137 221.448 222.536 291.17 187.88 187.58 210.529 239.448 192.694 236.197 213.306 194.591 228.445 394.952 134.59 336.278 108.399 131.118 262.023 131.181 105.788 199.025 250.632 136.027 155.485 321.909 205.626 198.202 523.998 5.66532 127.467 276.894 312.494 257.674 161.256 421.769 142.018 167.626 419.948 269.955 215.59 128.038
356.573 239.787 203.469 248.962 301.667 237.769 201.874 320.771 246.455 187.682 417.434 122.617 879.267 292.629 139.636 718.906 272.774 233.404 472.001 164.347 117.556 183.369 214.99 355.933 299.721 195.867 443.178 105.201 315.772 226.99 384.115 70.9439 200.851 211.799 163.917 227.282 205.479 146.321 201.659 256.361 55.5726 423.552 331.531 842.571 158.73 298.082 257.933 484.659 118.737 424.783 3.93245 93.6262 138.46 213.931 220.235 65.8217 126.909 55.9888 340.605 88.8336 82.6144 680.272
426.984 261.585 307.098 225.205 375.943 405.069 391.027 637.617 631.977 242.442 273.038 260.678 211.109 462.957 489.407 879.081 574.38 297.363 342.12 295.87 244.218 170.533 360.721 286.736 238.252 324.948 359.979 237.434 567.696 224.161 571.699 198.575 149.694 454.389 344.84 600.012 314.844 319.609 433.592 428.075 168.443 613.97 553.371 796.457 452.842 277.356 123.942 338.527 92.5166 2002.87 6.67455 101.186 76.5374 172.574 149.476 268.133 115.995 178.13 186.989 95.2313 76.5349 243.819
0.93 0.93 0.93 0.93 0.93 0.92 0.92 0.92 0.92 0.92 0.92 0.91 0.91 0.90 0.90 0.90 0.89 0.89 0.88 0.88 0.88 0.88 0.88 0.87 0.86 0.86 0.86 0.86 0.86 0.86 0.85 0.85 0.85 0.85 0.83 0.83 0.82 0.82 0.82 0.82 0.82 0.80 0.75 0.71 0.68 0.66 0.60 0.55 6.46 4.60 2.31 2.29 2.22 2.14 2.11 1.97 1.68 1.67 1.59 1.57 1.56 1.51
2.21 0.72 0.84 0.97 1.15 1.31 1.25 1.23 1.52 0.77 1.64 0.91 4.75 1.11 1.24 1.68 1.32 0.88 1.34 0.92 1.17 0.83 1.13 1.01 1.08 1.21 1.71 0.53 1.84 0.77 1.75 0.50 0.64 0.63 1.38 0.91 1.68 1.34 0.99 2.25 0.75 2.06 1.17 3.41 0.99 0.61 0.53 1.12 1.24 789.01 0.08 0.75 0.63 1.73 1.70 0.84 1.06 0.68 1.07 0.58 0.55 4.11
ACCEPTED MANUSCRIPT
123.458 100.666 299.63 201.97 112.985 210.904 122.333 140.446 146.239 294.079 192.712 219.009 135.345 156.385 234.888 248.882 153.519 181.661 146 60.6336 184.344 195.699 113.203 167.807 154.958 83.6061 126.755 109.275 106.051 260.871 167.97 183.042 128.8 170.871 224.56 142.59 234.54 155.593 35.6971 115.289 212.708 230.15 334.314 300.561 207.898 115.696 98.8473 238.138 213.729 236.722 243.751 167.71 243.133 346.952 186.809 179.529 250.779 189.787 138.823 95.9806 130.21 222.983
219.842 161.248 438.53 359.788 274.393 230.946 195.77 249.649 254.679 566.8 175.931 370.213 198.019 267.433 337.359 308.779 151.778 301.908 220.239 86.8648 233.523 231.917 179.32 282.29 235.219 160.536 154.394 168.915 180.539 363.973 255.106 305.293 201.619 251.759 283.806 197.198 322.874 245.509 54.9944 171.607 348.16 335.335 444.238 443.026 172.158 183.45 144.634 324.591 291.913 313.81 382.433 230.658 284.628 348.867 304.881 260.764 379.602 252.434 195.764 132.553 214.858 288.09
RI PT
151.543 102.911 276.165 219.488 175.356 183.349 110.927 160.875 157.742 351.69 143.655 251.261 159.576 175.044 217.725 130.299 117.616 213.569 138.917 60.9562 155.49 153.399 125.537 211.556 161.648 115.687 118.853 111.35 123.609 247.514 193.159 241.875 164.586 174.676 187.799 136.36 238.329 185.565 38.6049 143.307 266.466 268.236 301.725 324.051 168.289 147.067 109.274 241.187 234.975 188.929 276.031 192.541 220.2 265.142 229.91 187.947 315.567 215.772 161.127 95.5542 175.261 237.915
SC
4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
M AN U
TE D
Ndufb3 Cnpy2 Mrpl16 Dgat1 Gtpbp10 Exoc3 H2afz Pex11a Gbp6 Fam3c Rhob Ubr3 Marcksl1 Prps1 Tmco1 Ascc3 Tbc1d5 Camk2d Rfc4 Zfr Noc3l Spcs3 Mrpl45 Ndufb8 Stat6 Mprip Fam98b Tex2 Inpp1 Tmem63a Exoc7 Dpm1 Osbpl8 Polr1a Acbd5 Gabarapl1 Dnm1l Pdk1 Myo9b Tor1b Ntpcr Rab5a Cotl1 Ebna1bp2 Mrpl30 Pik3c3 Memo1 Lipa Mrc2 Abhd10 Fam45a Aimp2 Eftud1
SYF1_MOUSE Pre-mRNA-splicing factor SYF1 GRIN3_MOUSE G protein-regulated inducer of neurite outgrowth 3 RBCC1_MOUSE RB1-inducible coiled-coil protein 1 MOV10_MOUSE Putative helicase MOV-10 TBC13_MOUSE TBC1 domain family member 13 DHRS7_MOUSE Dehydrogenase/reductase SDR family member 7 RT34_MOUSE 28S ribosomal protein S34, mitochondrial SPB1_MOUSE pre-rRNA processing protein FTSJ3 CS052_MOUSE Uncharacterized protein C19orf52 homolog NDUB3_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 CNPY2_MOUSE Protein canopy homolog 2 RM16_MOUSE 39S ribosomal protein L16, mitochondrial DGAT1_MOUSE Diacylglycerol O-acyltransferase 1 GTPBA_MOUSE GTP-binding protein 10 EXOC3_MOUSE Exocyst complex component 3 H2AZ_MOUSE Histone H2A.Z PX11A_MOUSE Peroxisomal membrane protein 11A L7N1X8_MOUSE Protein Gbp6 FAM3C_MOUSE Protein FAM3C RHOB_MOUSE Rho-related GTP-binding protein RhoB UBR3_MOUSE E3 ubiquitin-protein ligase UBR3 MRP_MOUSE MARCKS-related protein PRPS1_MOUSE Ribose-phosphate pyrophosphokinase 1 TMCO1_MOUSE Transmembrane and coiled-coil domain-containing protein 1 ASCC3_MOUSE Activating signal cointegrator 1 complex subunit 3 TBCD5_MOUSE TBC1 domain family member 5 KCC2D_MOUSE Calcium/calmodulin-dependent protein kinase type II subunit delta RFC4_MOUSE Replication factor C subunit 4 ZFR_MOUSE Zinc finger RNA-binding protein NOC3L_MOUSE Nucleolar complex protein 3 homolog Q6ZWQ7_MOUSE Signal peptidase complex subunit 3 RM45_MOUSE 39S ribosomal protein L45, mitochondrial NDUB8_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial STAT6_MOUSE Signal transducer and transcription activator 6 MPRIP_MOUSE Myosin phosphatase Rho-interacting protein FA98B_MOUSE Protein FAM98B TEX2_MOUSE Testis-expressed sequence 2 protein INPP_MOUSE Inositol polyphosphate 1-phosphatase TM63A_MOUSE Transmembrane protein 63A EXOC7_MOUSE Exocyst complex component 7 DPM1_MOUSE Dolichol-phosphate mannosyltransferase subunit 1 B9EJ86_MOUSE Oxysterol-binding protein RPA1_MOUSE DNA-directed RNA polymerase I subunit RPA1 ACBD5_MOUSE Acyl-CoA-binding domain-containing protein 5 GBRL1_MOUSE Gamma-aminobutyric acid receptor-associated protein-like 1 DNM1L_MOUSE Isoform 3 of Dynamin-1-like protein PDK1_MOUSE [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial MYO9B_MOUSE Unconventional myosin-IXb TOR1B_MOUSE Torsin-1B NTPCR_MOUSE Cancer-related nucleoside-triphosphatase homolog RAB5A_MOUSE Ras-related protein Rab-5A COTL1_MOUSE Coactosin-like protein EBP2_MOUSE Probable rRNA-processing protein EBP2 RM30_MOUSE 39S ribosomal protein L30, mitochondrial PK3C3_MOUSE Phosphatidylinositol 3-kinase catalytic subunit type 3 MEMO1_MOUSE Protein MEMO1 LICH_MOUSE Lysosomal acid lipase/cholesteryl ester hydrolase MRC2_MOUSE C-type mannose receptor 2 ABHDA_MOUSE Mycophenolic acid acyl-glucuronide esterase, mitochondrial FA45A_MOUSE Protein FAM45A AIMP2_MOUSE Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 ETUD1_MOUSE Elongation factor Tu GTP-binding domain-containing protein 1
EP
Xab2 Gprin3 Rb1cc1 Mov10 Tbc1d13 Dhrs7 Mrps34 Ftsj3
AC C
sp|Q9DCD2|SYF1_MOUSE sp|Q8BWS5|GRIN3_MOUSE sp|Q9ESK9|RBCC1_MOUSE sp|P23249|MOV10_MOUSE sp|Q8R3D1|TBC13_MOUSE sp|Q9CXR1|DHRS7_MOUSE sp|Q9JIK9|RT34_MOUSE sp|Q9DBE9|SPB1_MOUSE sp|Q8BGX2|CS052_MOUSE sp|Q9CQZ6|NDUB3_MOUSE sp|Q9QXT0|CNPY2_MOUSE sp|Q99N93|RM16_MOUSE sp|Q9Z2A7|DGAT1_MOUSE sp|Q8K013|GTPBA_MOUSE sp|Q6KAR6|EXOC3_MOUSE sp|P0C0S6|H2AZ_MOUSE sp|Q9Z211|PX11A_MOUSE tr|L7N1X8|L7N1X8_MOUSE sp|Q91VU0|FAM3C_MOUSE sp|P62746|RHOB_MOUSE sp|Q5U430|UBR3_MOUSE sp|P28667|MRP_MOUSE sp|Q9D7G0|PRPS1_MOUSE sp|Q921L3|TMCO1_MOUSE sp|E9PZJ8|ASCC3_MOUSE sp|Q80XQ2|TBCD5_MOUSE sp|Q6PHZ2|KCC2D_MOUSE sp|Q99J62|RFC4_MOUSE sp|O88532|ZFR_MOUSE sp|Q8VI84|NOC3L_MOUSE tr|Q6ZWQ7|Q6ZWQ7_MOUSE sp|Q9D0Q7|RM45_MOUSE sp|Q9D6J5|NDUB8_MOUSE sp|P52633|STAT6_MOUSE sp|P97434|MPRIP_MOUSE sp|Q80VD1|FA98B_MOUSE sp|Q6ZPJ0|TEX2_MOUSE sp|P49442|INPP_MOUSE sp|Q91YT8|TM63A_MOUSE sp|O35250|EXOC7_MOUSE sp|O70152|DPM1_MOUSE tr|B9EJ86|B9EJ86_MOUSE sp|O35134|RPA1_MOUSE sp|Q5XG73|ACBD5_MOUSE sp|Q8R3R8|GBRL1_MOUSE sp|Q8K1M6-3|DNM1L_MOUSE sp|Q8BFP9|PDK1_MOUSE sp|Q9QY06|MYO9B_MOUSE sp|Q9ER41|TOR1B_MOUSE sp|Q9CQA9|NTPCR_MOUSE sp|Q9CQD1|RAB5A_MOUSE sp|Q9CQI6|COTL1_MOUSE sp|Q9D903|EBP2_MOUSE sp|Q9D7N6|RM30_MOUSE sp|Q6PF93|PK3C3_MOUSE sp|Q91VH6|MEMO1_MOUSE sp|Q9Z0M5|LICH_MOUSE sp|Q64449|MRC2_MOUSE sp|Q6PE15|ABHDA_MOUSE sp|Q9D8N2|FA45A_MOUSE sp|Q8R010|AIMP2_MOUSE sp|Q8C0D5|ETUD1_MOUSE
189.703 135.964 395.609 243.793 137.559 331.802 135.646 177.984 175.305 345.87 289.092 265.958 200.214 179.317 270.864 199.22 208.964 221.499 156.394 73.1172 210.725 221.873 130.587 208.545 174.103 96.5189 161.224 114.5 114.309 288.33 208.008 239.022 171.762 187.844 240.011 156.192 275.871 183.061 38.2923 152.125 250.733 286.512 347.729 329.562 291.822 139.231 110.679 261.311 254.573 204.202 249.195 207.079 276.977 392.791 199.8 183.875 303.674 236.698 163.016 95.8592 149.339 259.436
209.488 74.0663 286.46 191.881 136.626 228.432 91.5191 231.862 164.843 370.323 149.448 100.033 193.345 82.8269 335.685 398.694 558.112 176.32 188.763 876.534 153.394 136.186 143.217 208.781 285.133 99.9614 161.874 108.143 379.787 402.335 275.77 109.831 218.482 148.254 135.111 258.486 494.073 351.068 670.482 168.664 259.96 318.17 328.135 334.847 278.761 181.439 355.678 374.952 210.288 221.242 360.879 344.685 256.032 230.27 236.426 236.876 374.181 162.382 152.695 98.5686 737.088 383.837
190.747 81.2716 515.542 163.311 145.983 229.958 121.891 141.485 147.315 317.124 228.033 154.925 151.279 123.982 219.539 273.636 463.838 219.112 190.598 684.034 155.663 365.536 140.972 175.406 256.223 166.011 176.879 100.694 580.169 249.246 168.095 154.494 147.463 109.696 215.532 253.005 679.891 305.209 540.863 135.909 199.787 193.043 405.902 861.666 239.751 216.844 557.542 299.332 183.132 327.044 190.981 316.18 224.299 466.841 189.328 262.406 198.649 126.844 188.016 84.5228 405.362 365.431
1.49 1.46 1.45 1.43 1.43 1.43 1.42 1.42 1.41 1.41 1.38 1.35 1.35 1.35 1.34 1.34 1.33 1.32 1.32 1.32 1.31 1.30 1.30 1.29 1.29 1.29 1.29 1.28 1.28 1.28 1.28 1.28 1.27 1.27 1.27 1.27 1.27 1.26 1.26 1.25 1.25 1.25 1.25 1.24 1.23 1.23 1.23 1.22 1.22 1.22 1.22 1.22 1.21 1.21 1.21 1.21 1.21 1.21 1.20 1.19 1.19 1.19
1.46 0.76 1.39 0.84 0.98 1.16 0.91 1.24 1.03 1.06 1.12 0.54 1.17 0.62 1.23 1.77 3.77 1.00 1.33 12.83 0.91 1.44 1.19 1.01 1.71 1.33 1.38 0.95 4.18 1.28 1.23 0.62 1.25 0.75 0.85 1.83 2.48 1.92 16.30 1.18 0.96 1.03 1.15 1.92 1.38 1.52 4.39 1.41 0.88 1.29 1.06 1.83 1.04 1.14 1.02 1.36 1.01 0.71 1.14 0.96 3.74 1.63
ACCEPTED MANUSCRIPT
151.381 203.168 129.382 262.731 112.409 125.723 155.051 143.195 98.1145 229.997 146.686 148.481 242.999 173.178 123.929 207.764 99.9785 150.748 162.875 237.877 185.715 221.995 151.442 72.9858 181.802 228.598 201.158 177.531 173.715 229.683 230.39 181.777 114.206 161.99 290.894 250.541 260.811 240.051 261.766 169.68 201.085 155.422 350.201 149.441 191.573 109.203 244.988 216.241 171.753 248.252 138.413 114.258 211.888 148.48 268.083 130.307 418.759 185.179 149.505 162.709 290.869 227.418
208.109 247.505 183.053 332.236 171.754 155.63 225.846 172.274 146.248 370.505 161.761 184.636 288.235 201.463 137.475 208.992 146.453 206.897 175.444 261.137 225.797 219.617 163.395 98.1832 245.502 216.038 235.398 189.325 227.831 237.725 323.598 220.839 176.257 204.627 276.186 201.878 290.487 288.261 291.114 202.031 218.727 173.676 419.863 188.52 285.542 151.033 329.418 278.648 226.204 284.888 176.523 169.462 258.708 178.541 316.198 194.425 504.262 240.125 198.301 186.836 327.702 256.934
RI PT
171.375 215.597 142.084 303.33 133.415 132.135 177.903 130.938 103.624 298.194 123.634 174.626 260.326 150.416 128.874 199.705 108.595 163.565 146.472 216.1 184.083 179.542 144.89 72.9358 188.821 181.495 237.794 170.769 191.956 161.62 284.69 201.41 140.571 189.391 284.82 232.807 224.875 277.567 230.283 161.37 206.406 138.238 365.785 159.593 227.768 121.078 308.422 277.301 187.889 266.774 144.117 148.615 293.159 151.081 274.73 184.16 410.204 196.594 179.353 161.653 310.61 218.281
SC
4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
M AN U
TE D
Arhgap35 Trmt112 Wdr11 Ube3c Pet112 Golph3 Kpna6 Postn Sec24d Ppif Mrpl2 Tigar Ctnnbl1 Cxx1b Rars2 Tnpo2 Sh3bgrl3 Gulp1 Tbc1d9b Sptlc1 Immt Cops7a Drg2 Ralgapa2 Ppp1r12a Tbc1d15 Pbdc1 Ece1 Cuta Ttll12 Wapal Rrp1 Ubap1 Becn1 Sord Kiaa1033 Mterfd3 Nxf1 Mcmbp Copz2 Parl Raph1 Sh2b2 Chid1 Akr1b10 Rab5b Top3b Pi4ka Agpat3 Chchd1
PLCD1_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 RBM14_MOUSE RNA-binding protein 14 DIDO1_MOUSE Death-inducer obliterator 1 ERG7_MOUSE Lanosterol synthase TRI56_MOUSE E3 ubiquitin-protein ligase TRIM56 E41L5_MOUSE Band 4.1-like protein 5 Q8BH40_MOUSE Syntaxin 7 LRIG1_MOUSE Leucine-rich repeats and immunoglobulin-like domains protein 1 TBC23_MOUSE TBC1 domain family member 23 SNF8_MOUSE Vacuolar-sorting protein SNF8 RRS1_MOUSE Ribosome biogenesis regulatory protein homolog CT024_MOUSE Uncharacterized protein C20orf24 homolog RHG35_MOUSE Rho GTPase-activating protein 35 TR112_MOUSE tRNA methyltransferase 112 homolog WDR11_MOUSE WD repeat-containing protein 11 UBE3C_MOUSE Ubiquitin-protein ligase E3C GATB_MOUSE Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial GOLP3_MOUSE Golgi phosphoprotein 3 IMA7_MOUSE Importin subunit alpha-7 POSTN_MOUSE Periostin Q6NXL1_MOUSE Protein Sec24d PPIF_MOUSE Peptidyl-prolyl cis-trans isomerase F, mitochondrial RM02_MOUSE 39S ribosomal protein L2, mitochondrial TIGAR_MOUSE Fructose-2,6-bisphosphatase TIGAR CTBL1_MOUSE Beta-catenin-like protein 1 Q9D1F0_MOUSE CAAX box 1 homolog A (Human) SYRM_MOUSE Probable arginine--tRNA ligase, mitochondrial TNPO2_MOUSE Transportin-2 SH3L3_MOUSE SH3 domain-binding glutamic acid-rich-like protein 3 GULP1_MOUSE PTB domain-containing engulfment adapter protein 1 TBC9B_MOUSE TBC1 domain family member 9B SPTC1_MOUSE Serine palmitoyltransferase 1 IMMT_MOUSE Isoform 2 of Mitochondrial inner membrane protein CSN7A_MOUSE COP9 signalosome complex subunit 7a DRG2_MOUSE Developmentally-regulated GTP-binding protein 2 RGPA2_MOUSE Ral GTPase-activating protein subunit alpha-2 MYPT1_MOUSE Protein phosphatase 1 regulatory subunit 12A TBC15_MOUSE TBC1 domain family member 15 PBDC1_MOUSE Protein PBDC1 ECE1_MOUSE Endothelin-converting enzyme 1 CUTA_MOUSE Protein CutA TTL12_MOUSE Tubulin--tyrosine ligase-like protein 12 WAPL_MOUSE Wings apart-like protein homolog RRP1_MOUSE Ribosomal RNA processing protein 1 homolog A UBAP1_MOUSE Ubiquitin-associated protein 1 BECN1_MOUSE Beclin-1 DHSO_MOUSE Sorbitol dehydrogenase WASH7_MOUSE WASH complex subunit 7 MTER3_MOUSE mTERF domain-containing protein 3, mitochondrial NXF1_MOUSE Nuclear RNA export factor 1 MCMBP_MOUSE Mini-chromosome maintenance complex-binding protein COPZ2_MOUSE Coatomer subunit zeta-2 PARL_MOUSE Presenilins-associated rhomboid-like protein, mitochondrial F2Z3U3_MOUSE Protein Raph1 (Fragment) SH2B2_MOUSE SH2B adapter protein 2 CHID1_MOUSE Chitinase domain-containing protein 1 D3Z494_MOUSE MCG142264, isoform CRA_a RAB5B_MOUSE Ras-related protein Rab-5B TOP3B_MOUSE DNA topoisomerase 3-beta-1 E9Q3L2_MOUSE Protein Pi4ka PLCC_MOUSE 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma CHCH1_MOUSE Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
EP
Plcd1 Rbm14 Dido1 Lss Trim56 Epb41l5 Stx7 Lrig1 Tbc1d23 Snf8 Rrs1
AC C
sp|Q8R3B1|PLCD1_MOUSE sp|Q8C2Q3|RBM14_MOUSE sp|Q8C9B9|DIDO1_MOUSE sp|Q8BLN5|ERG7_MOUSE sp|Q80VI1|TRI56_MOUSE sp|Q8BGS1|E41L5_MOUSE tr|Q8BH40|Q8BH40_MOUSE sp|P70193|LRIG1_MOUSE sp|Q8K0F1|TBC23_MOUSE sp|Q9CZ28|SNF8_MOUSE sp|Q9CYH6|RRS1_MOUSE sp|Q9CQT9|CT024_MOUSE sp|Q91YM2|RHG35_MOUSE sp|Q9DCG9|TR112_MOUSE sp|Q8K1X1|WDR11_MOUSE sp|Q80U95|UBE3C_MOUSE sp|Q99JT1|GATB_MOUSE sp|Q9CRA5|GOLP3_MOUSE sp|O35345|IMA7_MOUSE sp|Q62009|POSTN_MOUSE tr|Q6NXL1|Q6NXL1_MOUSE sp|Q99KR7|PPIF_MOUSE sp|Q9D773|RM02_MOUSE sp|Q8BZA9|TIGAR_MOUSE sp|Q9CWL8|CTBL1_MOUSE tr|Q9D1F0|Q9D1F0_MOUSE sp|Q3U186|SYRM_MOUSE sp|Q99LG2|TNPO2_MOUSE sp|Q91VW3|SH3L3_MOUSE sp|Q8K2A1|GULP1_MOUSE sp|Q5SVR0|TBC9B_MOUSE sp|O35704|SPTC1_MOUSE sp|Q8CAQ8-2|IMMT_MOUSE sp|Q9CZ04|CSN7A_MOUSE sp|Q9QXB9|DRG2_MOUSE sp|A3KGS3|RGPA2_MOUSE sp|Q9DBR7|MYPT1_MOUSE sp|Q9CXF4|TBC15_MOUSE sp|Q9D0B6|PBDC1_MOUSE sp|Q4PZA2|ECE1_MOUSE sp|Q9CQ89|CUTA_MOUSE sp|Q3UDE2|TTL12_MOUSE sp|Q65Z40|WAPL_MOUSE sp|P56183|RRP1_MOUSE sp|Q8BH48|UBAP1_MOUSE sp|O88597|BECN1_MOUSE sp|Q64442|DHSO_MOUSE sp|Q3UMB9|WASH7_MOUSE sp|Q8BKY8|MTER3_MOUSE sp|Q99JX7|NXF1_MOUSE sp|Q8R3C0|MCMBP_MOUSE sp|Q9JHH9|COPZ2_MOUSE sp|Q5XJY4|PARL_MOUSE tr|F2Z3U3|F2Z3U3_MOUSE sp|Q9JID9|SH2B2_MOUSE sp|Q922Q9|CHID1_MOUSE tr|D3Z494|D3Z494_MOUSE sp|P61021|RAB5B_MOUSE sp|Q9Z321|TOP3B_MOUSE tr|E9Q3L2|E9Q3L2_MOUSE sp|Q9D517|PLCC_MOUSE sp|Q9CQA6|CHCH1_MOUSE
172.841 245.621 135.954 331.221 115.429 145.447 162.234 147.229 88.5389 242.888 151.634 189.557 292.946 171.807 153.874 259.144 92.8512 153.684 179.38 256.567 195.61 237.222 173.098 67.446 174.124 247.89 261.01 204.37 185.066 204.094 257.413 210.854 110.006 188.488 366.992 337.595 251.334 288.118 255.899 165.045 233.003 151.355 370.473 152.248 176.367 102.501 278.855 263.58 168.64 279.22 132.508 117.686 292.729 148.312 274.405 147.702 397.594 175.065 159.186 165.247 325.175 226.073
383.377 643.211 126.479 164.016 357.221 150.574 322.667 46.0653 387.659 234.89 107.599 147.72 211.17 123.054 203.915 236.911 138.245 199.543 158.013 83.2981 220.682 153.851 159.956 489.288 218.334 318.35 112.277 266.348 114.035 373.212 246.962 209.098 212.997 236.917 270.614 152.253 257.631 296.413 344.126 141.504 247.873 242.998 446.53 78.9943 142.181 132.181 178.247 305.04 173.123 364.039 139.84 119.674 327.687 263.346 299.305 138.715 406.166 263.494 161.191 256.741 301.62 137.434
296.542 744.505 291.73 141.286 394.478 93.2745 536.419 76.534 244.438 293.124 172.396 123.291 254.682 239.511 136.316 180.185 141.316 187.625 146.88 107.753 137.972 338.538 283.843 474.497 119.59 344.471 156.936 164.751 250.339 651.645 263.959 203.21 240.48 223.593 228.456 190.886 330.684 221.371 540.522 129.237 538.483 215.573 748.882 57.0691 366.05 118.054 362.465 159.28 282.304 321.828 126.265 101.925 215.545 384.557 372.638 106.457 487.269 178.563 148.615 166.377 270.112 261.148
1.18 1.18 1.18 1.17 1.17 1.17 1.17 1.17 1.16 1.16 1.16 1.16 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.14 1.14 1.14 1.14 1.14 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.12 1.12 1.12 1.12 1.12 1.11 1.11 1.11 1.11 1.11 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.08
2.11 3.31 1.54 0.54 3.06 0.95 2.58 0.45 3.13 1.00 1.04 0.84 0.93 1.12 1.35 1.02 1.34 1.23 0.99 0.42 0.97 1.23 1.50 6.60 0.91 1.62 0.61 1.24 1.00 2.62 0.99 1.08 1.78 1.31 0.87 0.71 1.21 1.00 1.80 0.82 1.93 1.56 1.67 0.44 1.21 1.09 0.98 0.94 1.27 1.33 0.94 0.84 1.08 2.16 1.24 0.78 1.08 1.16 0.94 1.30 0.95 0.89
ACCEPTED MANUSCRIPT
151.77 228.258 146.714 228.941 240.454 164.985 162.759 362.494 351.688 110.988 158.19 155.426 192.634 414.121 125.834 153.906 275.882 169.171 114.977 185.392 99.4349 171.199 292.749 229.918 111.495 90.656 77.3015 105.366 248.139 355.905 205.296 147.145 248.827 180.247 335.609 263.944 76.8881 241.688 171.073 193.622 281.455 126.007 26.0341 201.108 192.361 167.324 216.744 257.098 132.819 127.42 462.634 270.736 140.818 142.214 262.509 287.532 174.849 402.185 210.308 148.077 216.66 77.0988
174.752 294.029 169.081 289.859 314.717 219.31 200.217 419.596 396.5 139.015 199.866 170.712 215.324 509.515 171.991 180.617 338.545 219.325 153.745 251.627 121.968 252.534 360.095 253.59 145.711 121.21 95.6621 121.497 311.893 385.12 238.122 157.7 291.462 191.007 512.648 313.654 87.8001 256.116 216.511 275.912 301.28 160.691 37.2715 222.27 191.917 203.61 250.967 321.073 158.768 122.855 362.125 290.939 126.856 145.136 299.037 244.147 154.274 442.58 247.293 168.04 228.361 88.6077
RI PT
153.663 253.969 151.302 257.8 260.394 185.794 172.217 371.134 316.304 116.447 162.67 148.898 185.853 464.993 139.633 162.309 307.457 197.418 142.569 175.66 104.704 223.675 357.674 211.021 117.588 109.22 101.253 100.74 272.153 311.739 221.412 128.434 294.452 175.891 486.996 277.463 75.6764 214.91 210.953 244.354 296.045 151.219 29.514 185.259 201.839 210.786 249.494 314.778 143.687 104.67 374.238 271.85 110.424 144.157 274.701 233.159 130.516 399.16 231.052 178.601 197.974 84.937
SC
4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
M AN U
Map2k4 Gatad2b Ugt1a7c Trim47 Gcdh Fnbp1 Plaa Bsdc1 Pofut1 Rtn4ip1 Ecsit Kif21a Ppp1r14b Mrpl24 Smg1 Rpl34 Stk38 Klhl22 Nupl1 Uqcrh Ccnd2 Cux1 Mbd3 Ifi35 Nudcd3 Eny2 Gtf2e2 Adi1 Coq5 Cpsf2 Ptpn12 Rpa3
TE D
Pde4dip Serpinb9 Ppp1r8 Cpox
CD302_MOUSE CD302 antigen EXTL3_MOUSE Exostosin-like 3 NUB1_MOUSE NEDD8 ultimate buster 1 LGMN_MOUSE Legumain ATG3_MOUSE Ubiquitin-like-conjugating enzyme ATG3 LSM6_MOUSE U6 snRNA-associated Sm-like protein LSm6 CYFP1_MOUSE Cytoplasmic FMR1-interacting protein 1 RM49_MOUSE 39S ribosomal protein L49, mitochondrial MCEE_MOUSE Methylmalonyl-CoA epimerase, mitochondrial UBP16_MOUSE Ubiquitin carboxyl-terminal hydrolase 16 CPSF5_MOUSE Cleavage and polyadenylation specificity factor subunit 5 NXP20_MOUSE Protein Noxp20 PUM2_MOUSE Isoform 2 of Pumilio homolog 2 K0020_MOUSE Pumilio domain-containing protein KIAA0020 GOLI4_MOUSE Golgi integral membrane protein 4 EMD_MOUSE Emerin EI2BA_MOUSE Translation initiation factor eIF-2B subunit alpha RL39_MOUSE 60S ribosomal protein L39 TTC38_MOUSE Tetratricopeptide repeat protein 38 A2MP_MOUSE Alpha-2-macroglobulin-P COQ3_MOUSE Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial KDM1A_MOUSE Lysine-specific histone demethylase 1A CC50A_MOUSE Cell cycle control protein 50A RRP7A_MOUSE Ribosomal RNA-processing protein 7 homolog A CE051_MOUSE UPF0600 protein C5orf51 homolog MYOME_MOUSE Myomegalin O08797_MOUSE Protein Serpinb9 PP1R8_MOUSE Nuclear inhibitor of protein phosphatase 1 HEM6_MOUSE Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial CO040_MOUSE UPF0235 protein C15orf40 homolog MP2K4_MOUSE Dual specificity mitogen-activated protein kinase kinase 4 P66B_MOUSE Transcriptional repressor p66-beta UD17C_MOUSE UDP-glucuronosyltransferase 1-7C TRI47_MOUSE Isoform 2 of Tripartite motif-containing protein 47 GCDH_MOUSE Glutaryl-CoA dehydrogenase, mitochondrial FNBP1_MOUSE Formin-binding protein 1 PLAP_MOUSE Phospholipase A-2-activating protein BSDC1_MOUSE BSD domain-containing protein 1 OFUT1_MOUSE GDP-fucose protein O-fucosyltransferase 1 RT4I1_MOUSE Reticulon-4-interacting protein 1, mitochondrial ECSIT_MOUSE Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial KI21A_MOUSE Kinesin-like protein KIF21A PP14B_MOUSE Protein phosphatase 1 regulatory subunit 14B RM24_MOUSE 39S ribosomal protein L24, mitochondrial SMG1_MOUSE Serine/threonine-protein kinase SMG1 RL34_MOUSE 60S ribosomal protein L34 STK38_MOUSE Serine/threonine-protein kinase 38 KLH22_MOUSE Kelch-like protein 22 NUPL1_MOUSE Nucleoporin p58/p45 QCR6_MOUSE Cytochrome b-c1 complex subunit 6, mitochondrial CCND2_MOUSE G1/S-specific cyclin-D2 CUX1_MOUSE Homeobox protein cut-like 1 MBD3_MOUSE Methyl-CpG-binding domain protein 3 IN35_MOUSE Interferon-induced 35 kDa protein homolog NUDC3_MOUSE NudC domain-containing protein 3 ENY2_MOUSE Transcription and mRNA export factor ENY2 T2EB_MOUSE General transcription factor IIE subunit 2 MTND_MOUSE 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase COQ5_MOUSE 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial CPSF2_MOUSE Cleavage and polyadenylation specificity factor subunit 2 PTN12_MOUSE Tyrosine-protein phosphatase non-receptor type 12 RFA3_MOUSE Replication protein A 14 kDa subunit
EP
Cd302 Extl3 Nub1 Lgmn Atg3 Lsm6 Cyfip1 Mrpl49 Mcee Usp16 Nudt21 Fam114a1 Pum2 Kiaa0020 Golim4 Emd Eif2b1 Rpl39 Ttc38 A2mp Coq3 Kdm1a Tmem30a Rrp7a
AC C
sp|Q9DCG2|CD302_MOUSE sp|Q9WVL6|EXTL3_MOUSE sp|P54729|NUB1_MOUSE sp|O89017|LGMN_MOUSE sp|Q9CPX6|ATG3_MOUSE sp|P62313|LSM6_MOUSE sp|Q7TMB8|CYFP1_MOUSE sp|Q9CQ40|RM49_MOUSE sp|Q9D1I5|MCEE_MOUSE sp|Q99LG0|UBP16_MOUSE sp|Q9CQF3|CPSF5_MOUSE sp|Q9D281|NXP20_MOUSE sp|Q80U58-2|PUM2_MOUSE sp|Q8BKS9|K0020_MOUSE sp|Q8BXA1|GOLI4_MOUSE sp|O08579|EMD_MOUSE sp|Q99LC8|EI2BA_MOUSE sp|P62892|RL39_MOUSE sp|A3KMP2|TTC38_MOUSE sp|Q6GQT1|A2MP_MOUSE sp|Q8BMS4|COQ3_MOUSE sp|Q6ZQ88|KDM1A_MOUSE sp|Q8VEK0|CC50A_MOUSE sp|Q9D1C9|RRP7A_MOUSE sp|Q8BR90|CE051_MOUSE sp|Q80YT7|MYOME_MOUSE tr|O08797|O08797_MOUSE sp|Q8R3G1|PP1R8_MOUSE sp|P36552|HEM6_MOUSE sp|Q9CRC3|CO040_MOUSE sp|P47809|MP2K4_MOUSE sp|Q8VHR5|P66B_MOUSE sp|Q6ZQM8|UD17C_MOUSE sp|Q8C0E3-2|TRI47_MOUSE sp|Q60759|GCDH_MOUSE sp|Q80TY0|FNBP1_MOUSE sp|P27612|PLAP_MOUSE sp|Q80Y55|BSDC1_MOUSE sp|Q91ZW2|OFUT1_MOUSE sp|Q924D0|RT4I1_MOUSE sp|Q9QZH6|ECSIT_MOUSE sp|Q9QXL2|KI21A_MOUSE sp|Q62084|PP14B_MOUSE sp|Q9CQ06|RM24_MOUSE sp|Q8BKX6|SMG1_MOUSE sp|Q9D1R9|RL34_MOUSE sp|Q91VJ4|STK38_MOUSE sp|Q99JN2|KLH22_MOUSE sp|Q8R332|NUPL1_MOUSE sp|P99028|QCR6_MOUSE sp|P30280|CCND2_MOUSE sp|P53564|CUX1_MOUSE sp|Q9Z2D8|MBD3_MOUSE sp|Q9D8C4|IN35_MOUSE sp|Q8R1N4|NUDC3_MOUSE sp|Q9JIX0|ENY2_MOUSE sp|Q9D902|T2EB_MOUSE sp|Q99JT9|MTND_MOUSE sp|Q9CXI0|COQ5_MOUSE sp|O35218|CPSF2_MOUSE sp|P35831|PTN12_MOUSE sp|Q9CQ71|RFA3_MOUSE
155.57 227.358 152.73 235.389 225.396 158.644 160.504 369.745 321.905 104.51 143.454 154.844 189.262 428.912 110.774 155.816 281.553 169.947 119.611 131.481 94.1966 164.969 327.323 212.266 96.0027 88.7479 91.7535 94.7808 233.638 313.656 207.697 129.963 275.555 179.637 342.775 249.129 70.6316 218.003 178.733 177.002 295.704 125.817 20.0794 175.317 213.1 183.911 226.535 262.828 122.822 113.1 488.308 260.1 128.01 145.297 244.337 281.696 153.921 366.153 197.927 161.218 189.528 74.6159
97.9597 233.745 195.913 56.3237 276.326 194.859 167.135 182.029 61.8255 195.525 168.093 186.083 205.443 406.906 178.556 202.739 316.286 140.547 108.267 142.327 142.939 220.939 316.619 265.057 304.651 263.232 356.525 206.13 336.331 208.886 248.662 155.789 370.348 226.858 420.2 158.603 781.716 217.565 163.809 88.6733 174.64 115.404 387.695 71.2375 288.877 169.652 154.773 253 178.128 92.1044 242.701 297.242 99.3156 88.996 255.715 182.929 111.123 51.8011 105.355 212.476 318.252 104.764
124.181 172.286 153.837 110.784 398.606 228.411 111.067 408.078 415.491 244.155 158.514 151.783 329.252 353.293 177.019 211.9 264.318 284.481 139.033 188.334 490.242 171.149 268.027 322.945 307.051 194.533 299.555 294.51 271.17 501.55 201.727 370.376 191.908 198.799 524.233 390.558 565.631 523.635 163.064 143.751 318.305 168.521 956.153 231.191 214.281 145.696 173.141 269.882 154.853 342.16 392.886 337.345 288.702 227.635 351.964 389.723 201.267 246.42 175.829 240.782 217.599 136.535
1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01
0.73 0.84 1.17 0.34 1.35 1.21 0.83 0.80 0.71 1.93 1.02 1.11 1.41 0.86 1.34 1.31 1.00 1.16 0.96 0.92 3.10 0.99 0.90 1.33 2.67 2.29 3.67 2.43 1.17 1.06 1.06 1.91 1.03 1.20 1.15 1.01 8.83 1.62 0.86 0.53 0.85 1.02 24.19 0.78 1.28 0.83 0.70 0.91 1.20 1.87 0.76 1.17 1.54 1.11 1.13 1.10 1.02 0.37 0.64 1.39 1.29 1.49
ACCEPTED MANUSCRIPT
TE D
172.892 220.441 220.973 198.511 162.184 346.072 310.426 268.971 194.261 165.835 170.098 83.1093 141.201 177.772 162.253 255.146 140.757 186.021 311.224 288.357 448.188 220.178 219.615 230.338 141.07 194.122 220.189 147.366 306.559 335.623 121.065 223.878 151.921 251.626 234.458 198.476 217.316 134.706 199.959 172.576 206.585 201.604 286.482 136.257 286.454 187.501 108.68 221.079 171.211 170.576 237.133 234.953 260.139 173.033 163.744 391.028 180.536 102.533 160.516 201.787 254.181 134.08
153.556 232.453 212.437 224.595 154.867 315.913 320.154 296.584 231.774 175.289 157.63 85.2883 159.848 196.022 197.339 284.597 171.46 195.152 300.17 256.49 397.512 228.896 213.168 233.904 176.418 199.701 240.85 158.974 327.573 372.974 138.648 236.557 169.949 219.074 243.839 261.702 220.261 161.129 242.15 162.472 178.653 184.162 293.918 140.494 304.015 213.309 125.555 255.091 164.355 172.945 274.09 234.445 293.483 189.514 180.972 359.045 200.83 101.202 159.813 196.727 218.66 124.826
RI PT
159.314 207.362 226.072 231.502 186.392 253.849 293.167 311.394 246.737 149.227 154.98 83.9381 160.063 192.863 212.212 281.875 152.414 178.202 271.826 254.48 339.401 253.937 179.852 284.03 174.204 216.671 261.581 171.103 314.348 338.675 133.361 218.567 150.417 242.688 229.192 290.467 198.962 159.279 240.823 161.712 198.159 186.669 274.533 142.378 341.618 204.64 121.149 262.322 147.52 155.477 299.666 273.401 292.781 210.687 207.079 367.077 187.781 103.166 163.199 201.888 212.36 110.412
SC
4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
M AN U
TPC6B_MOUSE Trafficking protein particle complex subunit 6B NOP16_MOUSE Nucleolar protein 16 VPS11_MOUSE Vacuolar protein sorting-associated protein 11 homolog OXND1_MOUSE Oxidoreductase NAD-binding domain-containing protein 1 SPCS2_MOUSE Signal peptidase complex subunit 2 TXD17_MOUSE Thioredoxin domain-containing protein 17 ISY1_MOUSE Pre-mRNA-splicing factor ISY1 homolog INT4_MOUSE Integrator complex subunit 4 RAD21_MOUSE Double-strand-break repair protein rad21 homolog LAP2_MOUSE Protein LAP2 E9Q6Q4_MOUSE Protein Rap1gds1 PSMD5_MOUSE 26S proteasome non-ATPase regulatory subunit 5 IKIP_MOUSE Isoform 2 of Inhibitor of nuclear factor kappa-B kinase-interacting protein CC174_MOUSE Coiled-coil domain-containing protein 174 SCRB2_MOUSE Lysosome membrane protein 2 DIAC_MOUSE Di-N-acetylchitobiase CAPZB_MOUSE Isoform 2 of F-actin-capping protein subunit beta WIBG_MOUSE Partner of Y14 and mago CDK5_MOUSE Cyclin-dependent kinase 5 HTSF1_MOUSE HIV Tat-specific factor 1 homolog A2A5R8_MOUSE Double-stranded RNA-binding protein Staufen homolog 1 F7AC41_MOUSE Protein Pus7 (Fragment) UBL4A_MOUSE Ubiquitin-like protein 4A ANGL4_MOUSE Angiopoietin-related protein 4 GLYR1_MOUSE Putative oxidoreductase GLYR1 HACD3_MOUSE Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3 PPAL_MOUSE Lysosomal acid phosphatase DCTN3_MOUSE Dynactin subunit 3 CDK12_MOUSE Cyclin-dependent kinase 12 EDF1_MOUSE Endothelial differentiation-related factor 1 CJ118_MOUSE Uncharacterized protein C10orf118 homolog IFT20_MOUSE Intraflagellar transport protein 20 homolog PACN3_MOUSE Protein kinase C and casein kinase II substrate protein 3 COG3_MOUSE Conserved oligomeric Golgi complex subunit 3 AKAP8_MOUSE A-kinase anchor protein 8 HEXA_MOUSE Beta-hexosaminidase subunit alpha ROA0_MOUSE Heterogeneous nuclear ribonucleoprotein A0 DBLOH_MOUSE Diablo homolog, mitochondrial DNPEP_MOUSE Aspartyl aminopeptidase DSCR3_MOUSE Down syndrome critical region protein 3 homolog SC11A_MOUSE Signal peptidase complex catalytic subunit SEC11A UB2V2_MOUSE Ubiquitin-conjugating enzyme E2 variant 2 TM1L2_MOUSE TOM1-like protein 2 AASD1_MOUSE Alanyl-tRNA editing protein Aarsd1 STK39_MOUSE STE20/SPS1-related proline-alanine-rich protein kinase CTCF_MOUSE Transcriptional repressor CTCF TB10A_MOUSE TBC1 domain family member 10A VTA1_MOUSE Vacuolar protein sorting-associated protein VTA1 homolog P33MX_MOUSE Putative monooxygenase p33MONOX GLRX5_MOUSE Glutaredoxin-related protein 5, mitochondrial PTGR1_MOUSE Prostaglandin reductase 1 CDK4_MOUSE Cyclin-dependent kinase 4 STRN_MOUSE Striatin KT3K_MOUSE Ketosamine-3-kinase RRAS2_MOUSE Ras-related protein R-Ras2 UB2R1_MOUSE Ubiquitin-conjugating enzyme E2 R1 Q8K094_MOUSE Poliovirus receptor I2BP2_MOUSE Interferon regulatory factor 2-binding protein 2 UBL7_MOUSE Ubiquitin-like protein 7 FGFR1_MOUSE Fibroblast growth factor receptor 1 SNUT1_MOUSE U4/U6.U5 tri-snRNP-associated protein 1 CHMP5_MOUSE Charged multivesicular body protein 5
EP
Trappc6b Nop16 Vps11 Oxnad1 Spcs2 Txndc17 Isy1 Ints4 Rad21 Erbb2ip Rap1gds1 Psmd5 Ikbip Ccdc174 Scarb2 Ctbs Capzb Wibg Cdk5 Htatsf1 Stau1 Pus7 Ubl4a Angptl4 Glyr1 ptplad1 Acp2 Dctn3 Cdk12 Edf1 Otg1 Ift20 Pacsin3 Cog3 Akap8 Hexa Hnrnpa0 Diablo Dnpep Dscr3 Sec11a Ube2v2 Tom1l2 Aarsd1 Stk39 Ctcf Tbc1d10a Vta1 P33monox Glrx5 Ptgr1 Cdk4 Strn Fn3krp Rras2 Cdc34 Pvr Irf2bp2 Ubl7 Fgfr1 Sart1 Chmp5
AC C
sp|Q9D289|TPC6B_MOUSE sp|Q9CPT5|NOP16_MOUSE sp|Q91W86|VPS11_MOUSE sp|Q8VE38|OXND1_MOUSE sp|Q9CYN2|SPCS2_MOUSE sp|Q9CQM5|TXD17_MOUSE sp|Q69ZQ2|ISY1_MOUSE sp|Q8CIM8|INT4_MOUSE sp|Q61550|RAD21_MOUSE sp|Q80TH2|LAP2_MOUSE tr|E9Q6Q4|E9Q6Q4_MOUSE sp|Q8BJY1|PSMD5_MOUSE sp|Q9DBZ1-2|IKIP_MOUSE sp|Q3U155|CC174_MOUSE sp|O35114|SCRB2_MOUSE sp|Q8R242|DIAC_MOUSE sp|P47757-2|CAPZB_MOUSE sp|Q8CHP5|WIBG_MOUSE sp|P49615|CDK5_MOUSE sp|Q8BGC0|HTSF1_MOUSE tr|A2A5R8|A2A5R8_MOUSE tr|F7AC41|F7AC41_MOUSE sp|P21126|UBL4A_MOUSE sp|Q9Z1P8|ANGL4_MOUSE sp|Q922P9|GLYR1_MOUSE sp|Q8K2C9|HACD3_MOUSE sp|P24638|PPAL_MOUSE sp|Q9Z0Y1|DCTN3_MOUSE sp|Q14AX6|CDK12_MOUSE sp|Q9JMG1|EDF1_MOUSE sp|Q8C9S4|CJ118_MOUSE sp|Q61025|IFT20_MOUSE sp|Q99JB8|PACN3_MOUSE sp|Q8CI04|COG3_MOUSE sp|Q9DBR0|AKAP8_MOUSE sp|P29416|HEXA_MOUSE sp|Q9CX86|ROA0_MOUSE sp|Q9JIQ3|DBLOH_MOUSE sp|Q9Z2W0|DNPEP_MOUSE sp|O35075|DSCR3_MOUSE sp|Q9R0P6|SC11A_MOUSE sp|Q9D2M8|UB2V2_MOUSE sp|Q5SRX1|TM1L2_MOUSE sp|Q3THG9|AASD1_MOUSE sp|Q9Z1W9|STK39_MOUSE sp|Q61164|CTCF_MOUSE sp|P58802|TB10A_MOUSE sp|Q9CR26|VTA1_MOUSE sp|Q9DBN4|P33MX_MOUSE sp|Q80Y14|GLRX5_MOUSE sp|Q91YR9|PTGR1_MOUSE sp|P30285|CDK4_MOUSE sp|O55106|STRN_MOUSE sp|Q8K274|KT3K_MOUSE sp|P62071|RRAS2_MOUSE sp|Q8CFI2|UB2R1_MOUSE tr|Q8K094|Q8K094_MOUSE sp|E9Q1P8|I2BP2_MOUSE sp|Q91W67|UBL7_MOUSE sp|P16092|FGFR1_MOUSE sp|Q9Z315|SNUT1_MOUSE sp|Q9D7S9|CHMP5_MOUSE
180.058 196.539 234.876 204.775 191.834 279.866 278.98 279.107 205.287 136.844 163.726 79.4198 136.273 167.948 170.37 242.431 115.826 161.715 269.077 271.633 368.697 230.905 173.923 264.317 128.685 197.753 225.227 148.933 272.18 276.322 106.041 187.443 119.685 254.346 200.071 204.995 176.604 118.662 176.713 154.83 205.015 183.642 237.037 123.007 288.825 156.168 90.9197 199.929 135.501 133.684 230.396 243.201 223.084 168.693 164.58 346.667 141.615 90.0284 140.743 177.92 213.78 101.242
212.835 177.193 237.761 158.031 161.038 382.783 269.411 231.879 272.031 198.265 302.933 424.876 173.472 150.931 194.063 247.693 153.218 198.358 372.648 262.455 248.651 208.056 183.798 190.892 282.252 251.118 203.288 240.902 307.948 194.07 74.281 107.97 119.839 293.943 229.453 151.941 142.941 131.98 176.418 156.188 236.186 228.605 124.232 228.421 148.947 133.987 183.5 236.634 78.4978 169.416 283.001 198.626 202.073 164.254 270.135 282.793 306.957 96.908 119.585 100.373 132.05 170.008
169.853 339.355 205.483 282.965 121.598 875.682 519.824 247.627 486.692 332.936 236.791 280.668 94.7951 309.959 67.1277 349.497 149.553 264.122 287.498 631.262 872.144 201.357 338.29 439.911 360.841 212.966 133.238 263.269 436.322 389.021 127.796 257.189 216.661 242.908 397.832 77.2604 319.918 93.3738 198.281 100.927 141.935 349.923 178.279 415.032 123.138 158.018 317.036 217.245 185.348 535.604 277.639 208.903 360.514 240.26 219.422 726.572 185.291 271.535 247.366 161.94 190.582 434.627
1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.92
1.15 1.21 0.99 1.03 0.81 2.10 1.31 0.83 1.72 1.69 1.66 4.22 0.89 1.24 0.70 1.11 1.03 1.27 1.13 1.65 1.42 0.86 1.31 1.23 2.04 1.13 0.70 1.58 1.20 0.86 0.79 0.83 1.11 1.09 1.35 0.47 1.11 0.77 0.85 0.77 0.93 1.49 0.54 2.31 0.43 0.74 2.18 0.94 0.83 2.16 1.04 0.80 1.02 1.05 1.32 1.33 1.34 1.79 1.13 0.65 0.69 2.47
ACCEPTED MANUSCRIPT
129.402 265.137 190.5 172.608 169.115 151.174 133.721 263.185 288.702 224.024 367.866 300.429 154.334 153.647 305.431 255.552 249.603 392.672 107.886 225.426 146.006 139.379 221.818 124.527 250.11 302.238 213.839 193.827 294.545 182.612 144.263 198.002 338.87 206.71 161.875 248.339 292.44 313.094 181.391 282.324 263.948 234.639 216.933 241.143 266.213 715.261 49.5146 68.531 223.162 62.7924 59.7059 64.955 98.5943 39.9502 117.716 107.582 145.958 106.244 144.578 94.0254 105.657 78.8644
123.576 252.925 163.217 127.844 169.607 193.506 130.203 304.26 277.372 237.643 349.42 275.23 136.783 89.319 254.411 230.36 109.012 342.971 93.5036 216.829 119.719 140.006 206.585 125.533 206.9 290.909 155.568 185.151 249.701 179.791 130.495 159.008 255.938 179.9 128.924 240.184 204.995 229.081 156.106 188.848 217.405 158.747 164.033 135.533 153.162 188.728 95.2451 148.273 183.414 129.726 158.983 148.733 181.377 108.108 197.545 193.465 233.41 169.617 235.511 198.079 213.851 161.466
RI PT
103.031 328.697 161.576 131.31 196.836 208.313 137.014 346.466 265.66 273.486 322.453 310.448 151.073 101.344 322.009 219.114 215.722 390.861 90.6121 236.759 167.686 161.119 242.614 146.678 274.713 302.933 242.452 204.684 278.7 203.894 156.477 160.172 338.769 228.459 134.005 292.821 243.314 291.101 239.213 277.134 285.542 212.463 259.852 264.939 300.395 60.4136 20.1857 65.2002 104.638 61.8876 78.5067 72.3071 131.781 62.6984 64.5111 81.7135 163.514 98.9742 113.348 119.436 114.417 90.9365
SC
4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
TE D
SNAG_MOUSE Gamma-soluble NSF attachment protein GET4_MOUSE Golgi to ER traffic protein 4 homolog SPT4A_MOUSE Transcription elongation factor SPT4-A MA7D1_MOUSE MAP7 domain-containing protein 1 Z385A_MOUSE Zinc finger protein 385A PSDE_MOUSE 26S proteasome non-ATPase regulatory subunit 14 CPSF6_MOUSE Cleavage and polyadenylation specificity factor subunit 6 TWF2_MOUSE Twinfilin-2 PSMD9_MOUSE 26S proteasome non-ATPase regulatory subunit 9 IF4A3_MOUSE Eukaryotic initiation factor 4A-III ARCH_MOUSE Protein archease NADK_MOUSE NAD kinase SEC13_MOUSE Protein SEC13 homolog SLMO2_MOUSE Protein slowmo homolog 2 NDRG3_MOUSE Protein NDRG3 CNPY3_MOUSE Protein canopy homolog 3 VATL_MOUSE V-type proton ATPase 16 kDa proteolipid subunit YTHD3_MOUSE YTH domain-containing family protein 3 VATG1_MOUSE V-type proton ATPase subunit G 1 MPDZ_MOUSE Multiple PDZ domain protein SEH1_MOUSE Nucleoporin SEH1 CHTOP_MOUSE Chromatin target of PRMT1 protein GLPK_MOUSE Glycerol kinase SRSF2_MOUSE Serine/arginine-rich splicing factor 2 CREG1_MOUSE Protein CREG1 GRPE2_MOUSE GrpE protein homolog 2, mitochondrial AAKG1_MOUSE 5'-AMP-activated protein kinase subunit gamma-1 BCAR1_MOUSE Breast cancer anti-estrogen resistance protein 1 THYN1_MOUSE Thymocyte nuclear protein 1 ACY1_MOUSE Aminoacylase-1 NCOA1_MOUSE Nuclear receptor coactivator 1 DNJA4_MOUSE DnaJ homolog subfamily A member 4 Q99L20_MOUSE Glutathione S-transferase theta 3 RCOR1_MOUSE REST corepressor 1 RPB4_MOUSE DNA-directed RNA polymerase II subunit RPB4 DJC28_MOUSE DnaJ homolog subfamily C member 28 PPM1F_MOUSE Protein phosphatase 1F IMPCT_MOUSE Protein IMPACT GNPI1_MOUSE Glucosamine-6-phosphate isomerase 1 NRBP_MOUSE Nuclear receptor-binding protein GALNS_MOUSE N-acetylgalactosamine-6-sulfatase NC2A_MOUSE Dr1-associated corepressor HACL1_MOUSE 2-hydroxyacyl-CoA lyase 1 D3YZZ5_MOUSE Protein Tmed7 GFRP_MOUSE GTP cyclohydrolase 1 feedback regulatory protein HMGN2_MOUSE Non-histone chromosomal protein HMG-17 PLP2_MOUSE Proteolipid protein 2 NDRG2_MOUSE Protein NDRG2 DYL1_MOUSE Dynein light chain 1, cytoplasmic RET1_MOUSE Retinol-binding protein 1 MCM4_MOUSE DNA replication licensing factor MCM4 Q9ER67_MOUSE Maged2 protein Q8C6B0_MOUSE MCG20149, isoform CRA_a PCOC1_MOUSE Procollagen C-endopeptidase enhancer 1 H2A1_MOUSE Histone H2A type 1 PT100_MOUSE Protein PET100 homolog, mitochondrial ABCD2_MOUSE ATP-binding cassette sub-family D member 2 DDX24_MOUSE ATP-dependent RNA helicase DDX24 RM10_MOUSE 39S ribosomal protein L10, mitochondrial Q91Z40_MOUSE Gbp6 protein DDX51_MOUSE ATP-dependent RNA helicase DDX51 TAP1_MOUSE Antigen peptide transporter 1
EP
Napg Get4 Supt4h1a Map7d1 Znf385a Psmd14 Cpsf6 Twf2 Psmd9 Eif4a3 Zbtb8os Nadk Sec13 Slmo2 Ndrg3 Cnpy3 Atp6v0c Ythdf3 Atp6v1g1 Mpdz Seh1l Chtop Gk Srsf2 Creg1 Grpel2 Prkag1 Bcar1 Thyn1 Acy1 Ncoa1 Dnaja4 Gstt3 Rcor1 Polr2d Dnajc28 Ppm1f Impact Gnpda1 Nrbp1 Galns Drap1 Hacl1 Tmed7 Gchfr Hmgn2 Plp2 Ndrg2 Dynll1 Rbp1 Mcm4 Maged2 Mettl7a1 Pcolce Hist1h2ab Pet100 Abcd2 Ddx24 Mrpl10 Gbp7 Ddx51 Tap1
AC C
sp|Q9CWZ7|SNAG_MOUSE sp|Q9D1H7|GET4_MOUSE sp|P63271|SPT4A_MOUSE sp|A2AJI0|MA7D1_MOUSE sp|Q8VD12|Z385A_MOUSE sp|O35593|PSDE_MOUSE sp|Q6NVF9|CPSF6_MOUSE sp|Q9Z0P5|TWF2_MOUSE sp|Q9CR00|PSMD9_MOUSE sp|Q91VC3|IF4A3_MOUSE sp|Q505B7|ARCH_MOUSE sp|P58058|NADK_MOUSE sp|Q9D1M0|SEC13_MOUSE sp|Q9CYY7|SLMO2_MOUSE sp|Q9QYF9|NDRG3_MOUSE sp|Q9DAU1|CNPY3_MOUSE sp|P63082|VATL_MOUSE sp|Q8BYK6|YTHD3_MOUSE sp|Q9CR51|VATG1_MOUSE sp|Q8VBX6|MPDZ_MOUSE sp|Q8R2U0|SEH1_MOUSE sp|Q9CY57|CHTOP_MOUSE sp|Q64516|GLPK_MOUSE sp|Q62093|SRSF2_MOUSE sp|O88668|CREG1_MOUSE sp|O88396|GRPE2_MOUSE sp|O54950|AAKG1_MOUSE sp|Q61140|BCAR1_MOUSE sp|Q91YJ3|THYN1_MOUSE sp|Q99JW2|ACY1_MOUSE sp|P70365|NCOA1_MOUSE sp|Q9JMC3|DNJA4_MOUSE tr|Q99L20|Q99L20_MOUSE sp|Q8CFE3|RCOR1_MOUSE sp|Q9D7M8|RPB4_MOUSE sp|Q8VCE1|DJC28_MOUSE sp|Q8CGA0|PPM1F_MOUSE sp|O55091|IMPCT_MOUSE sp|O88958|GNPI1_MOUSE sp|Q99J45|NRBP_MOUSE sp|Q571E4|GALNS_MOUSE sp|Q9D6N5|NC2A_MOUSE sp|Q9QXE0|HACL1_MOUSE tr|D3YZZ5|D3YZZ5_MOUSE sp|P99025|GFRP_MOUSE sp|P09602|HMGN2_MOUSE sp|Q9R1Q7|PLP2_MOUSE sp|Q9QYG0|NDRG2_MOUSE sp|P63168|DYL1_MOUSE sp|Q00915|RET1_MOUSE sp|P49717|MCM4_MOUSE tr|Q9ER67|Q9ER67_MOUSE tr|Q8C6B0|Q8C6B0_MOUSE sp|Q61398|PCOC1_MOUSE sp|P22752|H2A1_MOUSE sp|P0DJE0|PT100_MOUSE sp|Q61285|ABCD2_MOUSE sp|Q9ESV0|DDX24_MOUSE sp|Q3TBW2|RM10_MOUSE tr|Q91Z40|Q91Z40_MOUSE sp|Q6P9R1|DDX51_MOUSE sp|P21958|TAP1_MOUSE
91.2873 293.755 159.415 149.154 163.267 133.171 115.738 248.784 225.196 211.472 271.071 272.726 136.504 137.25 297.822 185.893 298.267 336.174 77.7386 179.716 149.234 116.845 188.87 104.529 236.987 219.877 227.267 147.217 227.823 142.028 116.267 133.21 294.866 170.496 104.602 182.211 208.697 237.32 167.796 234.708 177.12 160.65 172.186 200.955 106.681 72.7697 194.51 139.362 487.115 122.013 119.729 127.211 250.499 81.1944 124.837 140.132 273.303 162.871 181.503 143.548 138.045 105.757
167.085 302.751 137.254 80.2872 133.366 179.102 249.751 194.958 215.321 190.271 252.311 317.727 253.391 91.073 281.489 171.901 229.712 269.475 71.3322 171.395 194.851 94.7626 332.256 105.079 179.68 217.909 330.7 173.072 416.501 132.653 107.823 237.322 626.902 159.435 201.114 104.037 177.507 144.085 198.328 273.012 210.31 140.029 155.458 190.902 177.41 102.828 107.66 254.457 357.153 75.8982 136.244 60.9997 119.047 20.3761 223.81 93.7527 75.9321 110.33 99.6601 78.5516 169.282 64.0553
338.497 213.195 264.427 169.491 224.656 179.95 303.791 273.624 385.555 168.945 435.338 383.114 396.475 205.171 387.461 318.722 260.649 374.998 183.928 325.887 189.408 169.106 262.111 194.761 264.152 356.624 240.036 187.616 802.946 172.804 291.414 223.198 1117.06 245.317 145.189 248.174 175.472 312.053 127.137 212.542 221.648 223.586 172.928 148.982 125.661 183.917 28.9813 332.897 135.168 85.0153 75.8306 37.9465 101.325 27.2592 97.1813 87.7364 86.4935 303.108 126.239 48.467 110.808 48.75
0.92 0.92 0.92 0.91 0.91 0.91 0.91 0.91 0.91 0.90 0.90 0.90 0.89 0.89 0.88 0.88 0.88 0.87 0.86 0.86 0.86 0.85 0.85 0.85 0.85 0.84 0.84 0.83 0.83 0.83 0.82 0.82 0.81 0.81 0.79 0.78 0.77 0.77 0.77 0.76 0.72 0.71 0.71 0.66 0.46 0.34 4.16 2.15 2.05 2.02 2.02 2.01 1.87 1.84 1.77 1.76 1.64 1.62 1.62 1.60 1.60 1.57
2.18 0.87 1.14 0.82 0.98 1.00 2.04 0.77 1.08 0.72 1.00 1.15 2.13 1.16 1.07 1.03 1.05 0.82 1.29 1.08 1.22 0.88 1.28 1.11 0.85 0.95 1.25 0.91 2.13 0.79 1.33 1.29 2.57 0.93 1.17 0.65 0.66 0.75 0.77 0.87 0.79 0.81 0.69 0.67 0.53 0.37 1.96 4.39 1.50 1.29 1.53 0.72 0.96 0.46 1.76 0.96 0.52 2.01 0.88 0.60 1.27 0.66
ACCEPTED MANUSCRIPT
TE D
117.705 90.1547 128.082 68.5752 179.761 89.7385 136.795 237.247 217.351 122.123 101.409 82.594 97.0459 135.084 114.744 66.8692 101.869 92.2279 85.3703 116.104 27.0063 113.051 197.705 93.5002 22.773 76.0802 103.694 71.6555 66.3823 110.298 83.9154 85.6538 70.9063 285.449 83.6734 170.852 162.749 78.4624 141.013 68.5138 159.115 44.386 101.427 21.5104 118.374 130.055 137.109 161.719 128.33 130.256 185.715 162.325 161.475 129.027 322.107 78.7455 128.038 125.412 129.927 212.198 81.9653 66.3383
157.992 217.56 151.712 112.954 292.29 150.321 338.863 194.621 345.768 246.745 177.142 133.324 170.202 219.023 186.702 187.632 222.835 146.85 159.091 174.861 110.244 237.045 346.402 176.26 39.8587 79.9582 180.385 100.497 98.3788 155.447 124.392 136.637 118.922 451.918 136.615 228.916 242.83 137.862 202.259 112.767 236.86 58.9485 190.099 32.7556 218.318 174.92 179.426 297.148 215.239 189.108 204.558 257.294 258.121 208.33 472.632 132.721 187.609 260.673 178.212 305.982 110.09 135.641
RI PT
98.3032 127.861 101.194 62.891 178.174 101.811 198.521 144.836 220.097 156.552 112.204 90.5249 109.208 145.046 129.623 136.151 163.153 106.47 98.2429 111.584 70.8404 157.844 242.151 114.081 27.7561 57.482 118.091 66.3903 66.1079 107.771 82.3411 96.9382 88.3395 262.504 92.9748 182.212 185.616 96.2012 169.862 68.7105 159.514 37.7973 129.161 21.4282 147.485 120.866 130.759 181.402 148.489 143.767 171.719 193.615 190.697 145.175 323.628 89.9796 136.98 202.331 141.778 250.687 83.4543 101.986
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
ATRX_MOUSE Transcriptional regulator ATRX KS6A5_MOUSE Ribosomal protein S6 kinase alpha-5 UBXN4_MOUSE UBX domain-containing protein 4 INF2_MOUSE Inverted formin-2 EXOC5_MOUSE Exocyst complex component 5 CLP1L_MOUSE Cleft lip and palate transmembrane protein 1-like protein ITB3_MOUSE Integrin beta-3 RTN1_MOUSE Reticulon-1 RARR2_MOUSE Retinoic acid receptor responder protein 2 D3Z7Q2_MOUSE Protein Smim20 SMDC1_MOUSE SAYSvFN domain-containing protein 1 ZZEF1_MOUSE Zinc finger ZZ-type and EF-hand domain-containing protein 1 TRM11_MOUSE tRNA (guanine(10)-N2)-methyltransferase homolog SPP2A_MOUSE Signal peptide peptidase-like 2A ALG2_MOUSE Alpha-1,3/1,6-mannosyltransferase ALG2 DPTOR_MOUSE DEP domain-containing mTOR-interacting protein CCD80_MOUSE Coiled-coil domain-containing protein 80 RRP44_MOUSE Exosome complex exonuclease RRP44 DHX30_MOUSE Putative ATP-dependent RNA helicase DHX30 RRP12_MOUSE RRP12-like protein TXNIP_MOUSE Thioredoxin-interacting protein THEM4_MOUSE Acyl-coenzyme A thioesterase THEM4 DOCK1_MOUSE Dedicator of cytokinesis protein 1 SYMPK_MOUSE Symplekin MYEF2_MOUSE Myelin expression factor 2 OXR1_MOUSE Oxidation resistance protein 1 RTCA_MOUSE RNA 3'-terminal phosphate cyclase RPOM_MOUSE DNA-directed RNA polymerase, mitochondrial GNAS2_MOUSE Guanine nucleotide-binding protein G(s) subunit alpha isoforms short BIG2_MOUSE Brefeldin A-inhibited guanine nucleotide-exchange protein 2 APLP2_MOUSE Amyloid-like protein 2 MVD1_MOUSE Diphosphomevalonate decarboxylase RBM28_MOUSE RNA-binding protein 28 DJC15_MOUSE DnaJ homolog subfamily C member 15 RAB3D_MOUSE Ras-related protein Rab-3D A2ANY6_MOUSE Midasin RAD50_MOUSE DNA repair protein RAD50 NQO2_MOUSE Ribosyldihydronicotinamide dehydrogenase [quinone] YLAT2_MOUSE Y+L amino acid transporter 2 BRD7_MOUSE Bromodomain-containing protein 7 PYRD_MOUSE Dihydroorotate dehydrogenase (quinone), mitochondrial RHOA_MOUSE Transforming protein RhoA GTPB1_MOUSE GTP-binding protein 1 FAF2_MOUSE FAS-associated factor 2 CB39L_MOUSE Calcium-binding protein 39-like E9PYK3_MOUSE Protein Parp4 PARP9_MOUSE Poly [ADP-ribose] polymerase 9 TX1B3_MOUSE Tax1-binding protein 3 E9Q735_MOUSE Protein Ube4a DDX50_MOUSE ATP-dependent RNA helicase DDX50 FLII_MOUSE Protein flightless-1 homolog ITM2B_MOUSE Integral membrane protein 2B CP2F2_MOUSE Cytochrome P450 2F2 E9Q137_MOUSE Protein Tex264 MCUR1_MOUSE Mitochondrial calcium uniporter regulator 1 SPCS_MOUSE O-phosphoseryl-tRNA(Sec) selenium transferase GPC4_MOUSE Glypican-4 ACD11_MOUSE Acyl-CoA dehydrogenase family member 11 LBR_MOUSE Lamin-B receptor ALG5_MOUSE Dolichyl-phosphate beta-glucosyltransferase NU133_MOUSE Nuclear pore complex protein Nup133 NFIB_MOUSE Nuclear factor 1 B-type
EP
Atrx Rps6ka5 Ubxn4 Inf2 Exoc5 Clptm1l Itgb3 Rtn1 Rarres2 Smim20 Saysd1 Zzef1 Trmt11 Sppl2a Alg2 Deptor Ccdc80 Dis3 Dhx30 Rrp12 Txnip Them4 Dock1 Sympk Myef2 Oxr1 RtcA Polrmt Gnas Arfgef2 Aplp2 Mvd Rbm28 Dnajc15 Rab3d Mdn1 Rad50 Nqo2 Slc7a6 Brd7 Dhodh Rhoa Gtpbp1 Faf2 Cab39l Parp4 Parp9 Tax1bp3 Ube4a Ddx50 Flii Itm2b Cyp2f2 Tex264 Mcur1 Sepsecs Gpc4 Acad11 Lbr Alg5 Nup133 Nfib
AC C
sp|Q61687|ATRX_MOUSE sp|Q8C050|KS6A5_MOUSE sp|Q8VCH8|UBXN4_MOUSE sp|Q0GNC1|INF2_MOUSE sp|Q3TPX4|EXOC5_MOUSE sp|Q8BXA5|CLP1L_MOUSE sp|O54890|ITB3_MOUSE sp|Q8K0T0|RTN1_MOUSE sp|Q9DD06|RARR2_MOUSE tr|D3Z7Q2|D3Z7Q2_MOUSE sp|Q8K190|SMDC1_MOUSE sp|Q5SSH7|ZZEF1_MOUSE sp|Q9CWH5|TRM11_MOUSE sp|Q9JJF9|SPP2A_MOUSE sp|Q9DBE8|ALG2_MOUSE sp|Q570Y9|DPTOR_MOUSE sp|Q8R2G6|CCD80_MOUSE sp|Q9CSH3|RRP44_MOUSE sp|Q99PU8|DHX30_MOUSE sp|Q6P5B0|RRP12_MOUSE sp|Q8BG60|TXNIP_MOUSE sp|Q3UUI3|THEM4_MOUSE sp|Q8BUR4|DOCK1_MOUSE sp|Q80X82|SYMPK_MOUSE sp|Q8C854|MYEF2_MOUSE sp|Q4KMM3|OXR1_MOUSE sp|Q9D7H3|RTCA_MOUSE sp|Q8BKF1|RPOM_MOUSE sp|P63094|GNAS2_MOUSE sp|A2A5R2|BIG2_MOUSE sp|Q06335|APLP2_MOUSE sp|Q99JF5|MVD1_MOUSE sp|Q8CGC6|RBM28_MOUSE sp|Q78YY6|DJC15_MOUSE sp|P35276|RAB3D_MOUSE tr|A2ANY6|A2ANY6_MOUSE sp|P70388|RAD50_MOUSE sp|Q9JI75|NQO2_MOUSE sp|Q8BGK6|YLAT2_MOUSE sp|O88665|BRD7_MOUSE sp|O35435|PYRD_MOUSE sp|Q9QUI0|RHOA_MOUSE sp|O08582|GTPB1_MOUSE sp|Q3TDN2|FAF2_MOUSE sp|Q9DB16|CB39L_MOUSE tr|E9PYK3|E9PYK3_MOUSE sp|Q8CAS9|PARP9_MOUSE sp|Q9DBG9|TX1B3_MOUSE tr|E9Q735|E9Q735_MOUSE sp|Q99MJ9|DDX50_MOUSE sp|Q9JJ28|FLII_MOUSE sp|O89051|ITM2B_MOUSE sp|P33267|CP2F2_MOUSE tr|E9Q137|E9Q137_MOUSE sp|Q9CXD6|MCUR1_MOUSE sp|Q6P6M7|SPCS_MOUSE sp|P51655|GPC4_MOUSE sp|Q80XL6|ACD11_MOUSE sp|Q3U9G9|LBR_MOUSE sp|Q9DB25|ALG5_MOUSE sp|Q8R0G9|NU133_MOUSE sp|P97863|NFIB_MOUSE
178.605 114.413 196.362 82.2913 233.508 130.835 150.819 362.328 287.191 156.08 130.253 115.382 125.767 182.884 162.95 100.236 152.752 134.541 100.589 145.891 27.4323 140.823 266.26 112.47 30.1691 105.12 126.857 90.5256 84.9338 145.505 105.04 115.329 100.719 302.567 105.781 253.811 230.684 99.5116 219.034 71.9107 191.856 51.3308 119.117 24.7627 136.455 157.489 174.219 154.912 147.341 169.729 263.174 207.084 200.283 148.543 367.174 85.6116 155.176 163.089 172.696 291.495 102.838 80.4925
95.7429 82.706 108.242 375.111 250.115 128.795 268.017 220.657 155.698 125.292 85.6321 88.0458 88.1791 152.854 151.585 165.652 59.521 138.715 87.9662 140.734 60.893 192.734 177.659 224.69 380.73 53.9235 140.589 123.777 90.0284 163.067 94.5372 73.9383 125.176 276.931 592.171 367.732 363.375 135.659 437.866 113.901 144.016 406.483 139.513 315.244 199.121 115.316 136.968 177.836 121.096 210.616 276.728 82.2014 84.6523 269.122 344.548 80.8766 200.624 465.964 207.203 212.375 175.221 52.2253
274.985 69.6519 145.333 496.188 217.107 85.1179 148.872 548.299 348.827 170.667 106.949 80.8033 95.2313 193.51 97.8637 216.889 97.5544 83.0507 176.132 86.3874 32.346 129.151 161.194 255.29 494.36 88.0842 126.189 138.138 60.3254 113.998 161.981 54.9807 145.038 318.464 553.876 410.067 271.584 125.507 189.605 168.709 155.429 327.221 117.956 324.593 119.871 120.589 148.998 179.5 122.453 175.955 152.401 137.58 168.592 230.131 263.329 51.8954 254.598 330.334 92.4309 188.016 120.305 90.4166
1.56 1.52 1.52 1.49 1.47 1.47 1.46 1.46 1.45 1.45 1.44 1.44 1.43 1.43 1.43 1.42 1.42 1.42 1.41 1.41 1.41 1.39 1.39 1.39 1.39 1.39 1.39 1.38 1.38 1.38 1.38 1.38 1.38 1.38 1.37 1.37 1.36 1.36 1.36 1.35 1.35 1.34 1.34 1.34 1.33 1.32 1.32 1.32 1.31 1.31 1.31 1.30 1.30 1.30 1.30 1.29 1.29 1.29 1.29 1.29 1.29 1.28
1.72 0.70 1.11 6.63 1.31 1.12 1.24 2.01 1.15 1.06 0.90 0.98 0.89 1.24 1.02 1.88 0.59 1.12 1.44 1.00 0.95 1.19 0.77 2.31 17.32 1.06 1.20 1.90 1.13 1.27 1.54 0.71 1.70 1.09 6.49 2.20 1.82 1.50 2.02 2.06 0.94 8.93 1.12 14.90 1.20 0.94 1.07 1.04 0.88 1.41 1.20 0.62 0.72 1.82 0.94 0.79 1.72 2.43 1.10 0.86 1.79 0.85
ACCEPTED MANUSCRIPT
Mrps2 Rhog Xrcc5 Slc12a4 Gak Wbp2 Pikfyve Znf622 Itgb5 Zc3h18
TE D
145.547 74.8036 219.354 79.8014 162.95 346.543 237.146 125.227 74.2153 176.067 318.927 150.428 120.793 112.017 132.744 162.14 227.799 122.33 144.853 56.7922 181.164 106.877 141.129 159.076 128.156 125.555 114.41 131.931 70.2327 68.735 114.934 146.279 105.545 153.302 99.6795 87.5526 158.918 113.885 179.294 103.937 175.312 146.939 129.791 155.687 122.413 215.287 114.26 965.199 105.104 90.6112 105.11 173.965 174.691 132.265 148.239 164.351 204.548 105.898 115.635 93.6212 129.088 188.196
267.979 93.9399 203.65 110.377 183.604 536.779 259.232 173.23 94.1532 262.085 392.217 222.204 162.145 183.278 208.831 249.383 280.35 201.021 244.714 89.9218 260.74 158.105 208.545 226.777 167.649 198.544 146.494 150.197 103.192 100.006 150.37 178.538 164.002 209.136 86.0657 99.1042 189.642 155.721 170.34 147.85 242.064 174.654 191.351 221.668 155.818 296.838 139.73 923.506 146.708 142.605 123.037 210.819 189.124 189.109 189.986 184.589 284.331 120.548 155.585 135.256 198.383 183.607
RI PT
209.765 57.7226 169.574 76.4631 120.879 386.064 201.983 135.09 69.0489 192.091 276.111 171.272 93.179 142.59 153.098 184.967 231.457 156.692 181.26 72.2082 191.349 120.004 156.342 184.687 131.151 148.931 115.739 108.517 78.7913 79.4645 109.91 152.647 124.15 174.232 67.8537 74.5545 145.61 131.149 177.214 113.153 201.222 143.849 158.235 183.893 118.342 262.573 126.682 538.306 126.576 112.59 95.8324 162.822 185.49 157.169 175.858 165.386 217.948 94.4064 116.643 109.363 164.475 136.668
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
PRP4B_MOUSE Serine/threonine-protein kinase PRP4 homolog BMP2K_MOUSE BMP-2-inducible protein kinase SUMO3_MOUSE Small ubiquitin-related modifier 3 IQEC1_MOUSE IQ motif and SEC7 domain-containing protein 1 ZNFX1_MOUSE NFX1-type zinc finger-containing protein 1 OPLA_MOUSE 5-oxoprolinase GRM1B_MOUSE GRAM domain-containing protein 1B SRGP2_MOUSE SLIT-ROBO Rho GTPase-activating protein 2 CUL7_MOUSE Cullin-7 VIP2_MOUSE Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 EXOC8_MOUSE Exocyst complex component 8 ASAP1_MOUSE Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 LRC57_MOUSE Leucine-rich repeat-containing protein 57 TM165_MOUSE Transmembrane protein 165 ABCB8_MOUSE ATP-binding cassette sub-family B member 8, mitochondrial SAAL1_MOUSE Protein SAAL1 PLXD1_MOUSE Plexin-D1 ZN512_MOUSE Zinc finger protein 512 SYVM_MOUSE Valine--tRNA ligase, mitochondrial TMX1_MOUSE Thioredoxin-related transmembrane protein 1 HS2ST_MOUSE Heparan sulfate 2-O-sulfotransferase 1 ENDD1_MOUSE Endonuclease domain-containing 1 protein ADNP_MOUSE Activity-dependent neuroprotector homeobox protein KDEL1_MOUSE KDEL motif-containing protein 1 MAGT1_MOUSE Magnesium transporter protein 1 ANO6_MOUSE Anoctamin-6 E9PWT1_MOUSE Transformation/transcription domain-associated protein MO4L1_MOUSE Isoform 2 of Mortality factor 4-like protein 1 XYLK_MOUSE Glycosaminoglycan xylosylkinase F6SAC3_MOUSE Glucose-6-phosphate isomerase STX5_MOUSE Syntaxin-5 DCAKD_MOUSE Dephospho-CoA kinase domain-containing protein SPAST_MOUSE Spastin MA1B1_MOUSE Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase RS21_MOUSE 40S ribosomal protein S21 AKP8L_MOUSE A-kinase anchor protein 8-like AAR2_MOUSE Protein AAR2 homolog NNMT_MOUSE Nicotinamide N-methyltransferase PAG15_MOUSE Group XV phospholipase A2 CA2D1_MOUSE Isoform 2C of Voltage-dependent calcium channel subunit alpha-2/delta-1 TPP2_MOUSE Isoform Short of Tripeptidyl-peptidase 2 G3X8R0_MOUSE Receptor accessory protein 5, isoform CRA_a PANK4_MOUSE Pantothenate kinase 4 COX11_MOUSE Cytochrome c oxidase assembly protein COX11, mitochondrial Q6PFF0_MOUSE Protein Scaf4 RAB34_MOUSE Ras-related protein Rab-34 UBR5_MOUSE E3 ubiquitin-protein ligase UBR5 PRRC1_MOUSE Protein PRRC1 MICU1_MOUSE Calcium uptake protein 1, mitochondrial EFR3A_MOUSE Protein EFR3 homolog A SR140_MOUSE U2 snRNP-associated SURP motif-containing protein CX038_MOUSE Uncharacterized protein CXorf38 homolog RT02_MOUSE 28S ribosomal protein S2, mitochondrial RHOG_MOUSE Rho-related GTP-binding protein RhoG XRCC5_MOUSE X-ray repair cross-complementing protein 5 S12A4_MOUSE Solute carrier family 12 member 4 GAK_MOUSE Cyclin-G-associated kinase WBP2_MOUSE WW domain-binding protein 2 FYV1_MOUSE 1-phosphatidylinositol 3-phosphate 5-kinase ZN622_MOUSE Zinc finger protein 622 ITB5_MOUSE Integrin beta-5 ZCH18_MOUSE Zinc finger CCCH domain-containing protein 18
EP
Prpf4b Bmp2k Sumo3 Iqsec1 Znfx1 Oplah Gramd1b Srgap2 Cul7 Ppip5k2 Exoc8 Asap1 Lrrc57 Tmem165 Abcb8 Saal1 Plxnd1 Znf512 Vars2 Tmx1 Hs2st1 Endod1 Adnp Kdelc1 Magt1 Ano6 Trrap Morf4l1 Fam20b Gm1840 Stx5 Dcakd Spast Man1b1 Rps21 Akap8l Aar2 Nnmt Pla2g15 Cacna2d1 Tpp2 Reep5 Pank4 Cox11 Scaf4 Rab34 Ubr5 Prrc1 Micu1 Efr3a U2surp
AC C
sp|Q61136|PRP4B_MOUSE sp|Q91Z96|BMP2K_MOUSE sp|Q9Z172|SUMO3_MOUSE sp|Q8R0S2|IQEC1_MOUSE sp|Q8R151|ZNFX1_MOUSE sp|Q8K010|OPLA_MOUSE sp|Q80TI0|GRM1B_MOUSE sp|Q91Z67|SRGP2_MOUSE sp|Q8VE73|CUL7_MOUSE sp|Q6ZQB6|VIP2_MOUSE sp|Q6PGF7|EXOC8_MOUSE sp|Q9QWY8|ASAP1_MOUSE sp|Q9D1G5|LRC57_MOUSE sp|P52875|TM165_MOUSE sp|Q9CXJ4|ABCB8_MOUSE sp|Q9D2C2|SAAL1_MOUSE sp|Q3UH93|PLXD1_MOUSE sp|Q69Z99|ZN512_MOUSE sp|Q3U2A8|SYVM_MOUSE sp|Q8VBT0|TMX1_MOUSE sp|Q8R3H7|HS2ST_MOUSE sp|Q8C522|ENDD1_MOUSE sp|Q9Z103|ADNP_MOUSE sp|Q9JHP7|KDEL1_MOUSE sp|Q9CQY5|MAGT1_MOUSE sp|Q6P9J9|ANO6_MOUSE tr|E9PWT1|E9PWT1_MOUSE sp|P60762-2|MO4L1_MOUSE sp|Q8VCS3|XYLK_MOUSE tr|F6SAC3|F6SAC3_MOUSE sp|Q8K1E0|STX5_MOUSE sp|Q8BHC4|DCAKD_MOUSE sp|Q9QYY8|SPAST_MOUSE sp|A2AJ15|MA1B1_MOUSE sp|Q9CQR2|RS21_MOUSE sp|Q9R0L7|AKP8L_MOUSE sp|Q9D2V5|AAR2_MOUSE sp|O55239|NNMT_MOUSE sp|Q8VEB4|PAG15_MOUSE sp|O08532-3|CA2D1_MOUSE sp|Q64514-2|TPP2_MOUSE tr|G3X8R0|G3X8R0_MOUSE sp|Q80YV4|PANK4_MOUSE sp|Q6P8I6|COX11_MOUSE tr|Q6PFF0|Q6PFF0_MOUSE sp|Q64008|RAB34_MOUSE sp|Q80TP3|UBR5_MOUSE sp|Q3UPH1|PRRC1_MOUSE sp|Q8VCX5|MICU1_MOUSE sp|Q8BG67|EFR3A_MOUSE sp|Q6NV83|SR140_MOUSE sp|Q8C5K5|CX038_MOUSE sp|Q924T2|RT02_MOUSE sp|P84096|RHOG_MOUSE sp|P27641|XRCC5_MOUSE sp|Q9JIS8|S12A4_MOUSE sp|Q99KY4|GAK_MOUSE sp|P97765|WBP2_MOUSE sp|Q9Z1T6|FYV1_MOUSE sp|Q91VY9|ZN622_MOUSE sp|O70309|ITB5_MOUSE sp|Q0P678|ZCH18_MOUSE
187.835 76.0485 294.829 87.9644 175.311 384.631 291.868 152.443 84.6521 196.687 349.222 177.607 103.395 132.62 145.438 180.408 287.92 144.091 158.273 68.6564 196.858 120.52 156.607 195.061 150.226 137.188 134.445 143.123 78.3274 80.3793 122.422 183.875 113.676 186.085 115.956 96.3092 176.228 138.616 255.59 111.039 206.074 171.083 151.062 181.042 129.295 268.677 145.205 853.929 127.007 96.9054 113.199 184.912 232.687 149.758 189.455 201.439 210.207 113.453 115.733 101.79 144.097 195.223
155.916 92.4452 133.638 276.826 123.079 113.675 127.87 203.421 50.6865 191.391 293.398 224.876 168.728 155.901 104.769 308.77 147.236 109.743 206.214 159.186 309.701 119.462 205.326 119.812 136.488 252.666 125.154 143.006 55.9633 128.091 163.07 204.797 72.3952 234.899 291.231 126.778 179.735 188.785 242.701 161.661 216.872 195.201 186.498 64.8801 121.226 279.635 132.929 644.854 126.661 84.5043 137.369 109.731 92.9812 205.477 119.938 184.854 207.184 64.2856 122.128 176.385 177.695 134.142
154.234 120.92 396.946 607.011 161.881 91.4702 268.012 143.794 65.7444 112.85 264.896 243.856 173.931 128.533 82.3372 184.925 251.063 70.2277 172.683 129.407 132.658 477.448 329.464 133.805 96.4288 129.094 123.381 162.887 52.1558 88.0854 134.737 124.022 103.49 160.147 549.466 202.273 158.504 250.471 258.657 154.275 134.899 249.048 166.538 142.616 174.292 188.128 169.633 806.007 99.9442 63.9983 180.817 184.798 157.589 158.025 128.071 178.538 526.853 59.5686 149.663 129.884 126.96 367.05
1.28 1.28 1.28 1.27 1.26 1.26 1.25 1.25 1.25 1.25 1.25 1.24 1.24 1.24 1.24 1.24 1.24 1.24 1.24 1.23 1.23 1.23 1.23 1.23 1.23 1.22 1.22 1.22 1.22 1.22 1.21 1.21 1.21 1.21 1.21 1.21 1.20 1.20 1.19 1.19 1.19 1.19 1.19 1.19 1.18 1.18 1.18 1.18 1.18 1.18 1.18 1.18 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17
0.87 1.61 1.36 5.66 1.00 0.28 0.90 1.33 0.81 0.83 0.94 1.46 1.60 1.12 0.65 1.42 0.87 0.65 1.16 2.24 1.19 2.63 1.80 0.74 0.90 1.39 1.08 1.27 0.73 1.46 1.32 1.10 0.77 1.21 5.02 2.03 1.11 1.79 1.41 1.46 0.93 1.53 1.23 0.61 1.23 0.98 1.26 0.96 0.98 0.73 1.58 0.87 0.70 1.26 0.77 1.10 1.74 0.62 1.17 1.51 1.04 1.54
ACCEPTED MANUSCRIPT
Wdr82 Dcun1d1 Ppp1r18 Mgat1
Gnl1 Pus1 Nup160 Fryl Tlk2 Tbcb Lims1
93.8717 92.1686 254.997 144.995 109.937 136.182 65.6921 267.116 121.368 134.618 92.9147 204.559 191.142 80.5167 121.947 121.813 73.5598 69.4767 161.58 167.933 179.906 150.055 128.573 248.874 158.215 204.497 178.056 126.655 121.487 142.917 106.4 60.8577 185.56 111.647 91.8733 90.4275 125.4 186.533 117.026 133.769 142.072 203.967 157.012 133.153 122.7 89.4186 222.133 194.971 129.15 115.599 47.6864 175.728 132.727 162.233 182.293 107.228 230.657 155.91 189.025 159.618 122.042 185.604
114.998 127.449 301.887 214.775 134.767 183.259 89.8836 339.256 163.629 182.866 128.254 247.662 282.693 104.439 149.46 137.588 94.3352 99.3158 203.252 232.42 244.686 192.148 159.756 281.813 147.405 289.917 266.416 150.359 156.772 111.303 127.858 84.3699 256.131 143.025 144.843 109.694 104.052 179.442 150.608 149.315 134.59 258.268 198.648 155.668 176.561 107.182 270.298 230.86 172.685 150.115 63.4501 193.383 171.56 164.147 187.527 138.882 293.249 135.282 144.256 180.843 149.098 208.996
RI PT
110.578 109.007 250.52 201.225 119.663 144.385 55.9516 323.445 138.143 153.267 105.814 224.225 225.412 99.7291 117.242 129.238 63.5595 83.768 173.125 189.384 200.075 156.581 127.1 261.084 143.45 258.5 224.302 128.544 130.323 108.203 105.18 65.0863 205.949 121.32 118.034 98.6529 124.217 146.938 120.454 134.579 110.869 276.392 182.178 138.682 167.95 83.0165 214.727 199.033 134.34 135.388 62.0134 153.793 136.34 154.298 188.073 119.496 244.673 156.745 168.843 172.393 119.966 183.966
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
TE D
Dnajc10 Pmvk Glipr2 Tpm3 Kdelc2 Trmt6 Cers2 Vcpip1 Srsf9 Gpx7 Gcat Pdzk1 Jmjd6 Specc1 Gnai2 Ddx18 Btaf1 Tor1a Snx18 Pex13 Pttg1ip Hectd1 Otud4 Athl1 Mrpl44 Arsa Sec24c Aqr Cenpe Gosr1 Gm5069 Exosc7 Pkn1 Sec61a1 Wdr43 Sgcd Adam17 Mon2 Mrpl22 Ttc39b Ddx19b Akr1e2 Creld2 Timm8b Ptges
DPP9_MOUSE Dipeptidyl peptidase 9 EI2BE_MOUSE Translation initiation factor eIF-2B subunit epsilon CS012_MOUSE Protein C19orf12 homolog DJC10_MOUSE DnaJ homolog subfamily C member 10 PMVK_MOUSE Phosphomevalonate kinase GAPR1_MOUSE Golgi-associated plant pathogenesis-related protein 1 TPM3_MOUSE Isoform 2 of Tropomyosin alpha-3 chain G5E897_MOUSE KDEL (Lys-Asp-Glu-Leu) containing 2, isoform CRA_b TRM6_MOUSE tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 CERS2_MOUSE Ceramide synthase 2 VCIP1_MOUSE Deubiquitinating protein VCIP135 SRSF9_MOUSE Serine/arginine-rich splicing factor 9 GPX7_MOUSE Glutathione peroxidase 7 KBL_MOUSE 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial NHRF3_MOUSE Na(+)/H(+) exchange regulatory cofactor NHE-RF3 JMJD6_MOUSE Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 CYTSB_MOUSE Cytospin-B GNAI2_MOUSE Guanine nucleotide-binding protein G(i) subunit alpha-2 DDX18_MOUSE ATP-dependent RNA helicase DDX18 E9QAE3_MOUSE Protein Btaf1 TOR1A_MOUSE Torsin-1A Q8C788_MOUSE Sorting nexin PEX13_MOUSE Peroxisomal membrane protein PEX13 PTTG_MOUSE Pituitary tumor-transforming gene 1 protein-interacting protein HECD1_MOUSE E3 ubiquitin-protein ligase HECTD1 OTUD4_MOUSE OTU domain-containing protein 4 ATHL1_MOUSE Acid trehalase-like protein 1 RM44_MOUSE 39S ribosomal protein L44, mitochondrial ARSA_MOUSE Arylsulfatase A G3X972_MOUSE Protein Sec24c AQR_MOUSE Intron-binding protein aquarius CENPE_MOUSE Centromere-associated protein E GOSR1_MOUSE Golgi SNAP receptor complex member 1 D3Z0Z9_MOUSE Glyceraldehyde-3-phosphate dehydrogenase EXOS7_MOUSE Exosome complex exonuclease RRP42 PKN1_MOUSE Serine/threonine-protein kinase N1 S61A1_MOUSE Protein transport protein Sec61 subunit alpha isoform 1 WDR43_MOUSE WD repeat-containing protein 43 SGCD_MOUSE Delta-sarcoglycan ADA17_MOUSE Disintegrin and metalloproteinase domain-containing protein 17 MON2_MOUSE Protein MON2 homolog RM22_MOUSE 39S ribosomal protein L22, mitochondrial TT39B_MOUSE Tetratricopeptide repeat protein 39B Q8BZY3_MOUSE Protein Ddx19b AKCL2_MOUSE 1,5-anhydro-D-fructose reductase CREL2_MOUSE Cysteine-rich with EGF-like domain protein 2 TIM8B_MOUSE Mitochondrial import inner membrane translocase subunit Tim8 B PTGES_MOUSE Prostaglandin E synthase CI041_MOUSE UPF0586 protein C9orf41 homolog WDR82_MOUSE WD repeat-containing protein 82 DCNL1_MOUSE DCN1-like protein 1 PPR18_MOUSE Phostensin MGAT1_MOUSE Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase CP062_MOUSE UPF0505 protein C16orf62 homolog CJ076_MOUSE UPF0668 protein C10orf76 homolog GNL1_MOUSE Guanine nucleotide-binding protein-like 1 TRUA_MOUSE tRNA pseudouridine synthase A, mitochondrial NU160_MOUSE Nuclear pore complex protein Nup160 F8VQ05_MOUSE Protein Fryl TLK2_MOUSE Serine/threonine-protein kinase tousled-like 2 TBCB_MOUSE Tubulin-folding cofactor B LIMS1_MOUSE LIM and senescent cell antigen-like-containing domain protein 1
EP
Dpp9 Eif2b5
AC C
sp|Q8BVG4|DPP9_MOUSE sp|Q8CHW4|EI2BE_MOUSE sp|Q8WUR0|CS012_MOUSE sp|Q9DC23|DJC10_MOUSE sp|Q9D1G2|PMVK_MOUSE sp|Q9CYL5|GAPR1_MOUSE sp|P21107-2|TPM3_MOUSE tr|G5E897|G5E897_MOUSE sp|Q8CE96|TRM6_MOUSE sp|Q924Z4|CERS2_MOUSE sp|Q8CDG3|VCIP1_MOUSE sp|Q9D0B0|SRSF9_MOUSE sp|Q99LJ6|GPX7_MOUSE sp|O88986|KBL_MOUSE sp|Q9JIL4|NHRF3_MOUSE sp|Q9ERI5|JMJD6_MOUSE sp|Q5SXY1|CYTSB_MOUSE sp|P08752|GNAI2_MOUSE sp|Q8K363|DDX18_MOUSE tr|E9QAE3|E9QAE3_MOUSE sp|Q9ER39|TOR1A_MOUSE tr|Q8C788|Q8C788_MOUSE sp|Q9D0K1|PEX13_MOUSE sp|Q8R143|PTTG_MOUSE sp|Q69ZR2|HECD1_MOUSE sp|B2RRE7|OTUD4_MOUSE sp|Q8BP56|ATHL1_MOUSE sp|Q9CY73|RM44_MOUSE sp|P50428|ARSA_MOUSE tr|G3X972|G3X972_MOUSE sp|Q8CFQ3|AQR_MOUSE sp|Q6RT24|CENPE_MOUSE sp|O88630|GOSR1_MOUSE tr|D3Z0Z9|D3Z0Z9_MOUSE sp|Q9D0M0|EXOS7_MOUSE sp|P70268|PKN1_MOUSE sp|P61620|S61A1_MOUSE sp|Q6ZQL4|WDR43_MOUSE sp|P82347|SGCD_MOUSE sp|Q9Z0F8|ADA17_MOUSE sp|Q80TL7|MON2_MOUSE sp|Q8BU88|RM22_MOUSE sp|Q8BYY4|TT39B_MOUSE tr|Q8BZY3|Q8BZY3_MOUSE sp|Q9DCT1|AKCL2_MOUSE sp|Q9CYA0|CREL2_MOUSE sp|P62077|TIM8B_MOUSE sp|Q9JM51|PTGES_MOUSE sp|Q80UY1|CI041_MOUSE sp|Q8BFQ4|WDR82_MOUSE sp|Q9QZ73|DCNL1_MOUSE sp|Q8BQ30|PPR18_MOUSE sp|P27808|MGAT1_MOUSE sp|Q8BWQ6|CP062_MOUSE sp|Q6PD19|CJ076_MOUSE sp|P36916|GNL1_MOUSE sp|Q9WU56|TRUA_MOUSE sp|Q9Z0W3|NU160_MOUSE tr|F8VQ05|F8VQ05_MOUSE sp|O55047|TLK2_MOUSE sp|Q9D1E6|TBCB_MOUSE sp|Q99JW4|LIMS1_MOUSE
122.858 106.481 285.188 186.102 130.802 140.932 50.4593 342.077 135.445 148.765 100.669 245.991 196.272 102.501 124.882 149.888 62.2967 75.5135 178.094 173.633 186.936 155.08 128.924 293.046 192.281 230.42 185.32 136.112 125.868 170.024 109.125 56.5103 181.629 117.198 89.2227 101.089 174.206 190.97 112.271 146.953 144.428 271.57 175.437 143.785 143.256 82.2955 208.527 200.754 115.386 123.969 56.0523 165.027 120.956 179.76 214.833 107.196 222.619 203.819 243.178 178.59 112.846 190.478
80.709 115.86 164.935 175.75 122.161 193.568 451.073 290.837 115.979 134.595 109.224 179.411 135.738 75.4325 120.654 108.005 93.9007 756.548 128.097 186.801 198.85 133.465 116.665 202.772 117.757 153.733 159.162 81.5068 104.693 223.342 36.643 209.871 242.386 217.371 119.346 100.452 623.006 144.848 127.446 155.334 157.581 104.508 220.223 166.767 140.732 78.9815 114.434 236.823 140.231 129.302 218.845 142.387 143.751 475.336 158.699 168.88 220.797 227.252 248.651 198.192 153.112 430.579
75.6749 95.1324 234.623 124.78 166.714 268.145 1137.69 229.314 108 112.057 226.6 379.279 204.458 76.8979 278.052 140.537 146.178 559.269 55.0823 141.905 158.261 197.726 83.942 127.544 161.167 225.828 118.035 132.395 111.31 202.904 31.5569 270.617 259.929 175.026 98.0943 125.566 396.889 96.9467 112.398 151.423 158.76 244.338 273.332 143.417 150.008 183.046 332.061 177.715 215.468 113.557 174.984 186.332 152.146 299.846 124.875 124.174 184.432 153.398 285.645 149.75 283.884 589.047
1.16 1.16 1.16 1.16 1.16 1.16 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.14 1.14 1.14 1.14 1.14 1.13 1.13 1.13 1.13 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.11 1.11 1.11 1.11 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.08 1.08 1.08 1.08 1.08
0.76 1.05 0.79 0.87 1.26 1.65 13.06 0.88 0.86 0.86 1.69 1.30 0.82 0.85 1.67 0.99 1.75 8.59 0.55 0.92 0.94 1.08 0.78 0.65 0.92 0.82 0.69 0.84 0.86 1.70 0.32 3.82 1.28 1.68 1.04 1.20 4.09 0.73 1.01 1.14 1.25 0.73 1.46 1.14 1.00 1.52 1.02 1.05 1.35 0.97 3.59 1.00 1.10 2.45 0.77 1.29 0.85 1.22 1.49 1.05 1.81 2.76
ACCEPTED MANUSCRIPT
Cacul1 Aga Nt5c2 Nudt4 Raver1 Mtif3 Oxsm Ctr9 Vldlr Spag7 Farp2 Triobp Rpl37a Prps2 Fyco1 Zc3h4 Aamdc Ssr4 Carm1 Gga2
178.676 121.152 172.435 131.331 212.582 104.691 186.582 96.9483 73.8867 143.853 217.256 76.6089 170.97 142.323 209.321 88.5361 192.026 143.951 181.17 225.588 56.4126 108.363 101.709 128.377 95.5672 104.081 85.798 38.8107 170.249 151.089 74.3675 134.978 121.145 85.663 148.421 106.863 197.697 284.713 111.617 257.097 209.496 95.8069 129.383 66.815 119.432 95.387 146.065 315.643 78.0293 151.415 136.385 200.774 154.817 109.33 127.804 66.6535 163.88 93.0836 216.831 326.731 212.881 116.739
197.511 146.343 193.621 160.855 205.901 127.866 235.588 128.764 97.2454 176.683 287.017 106.836 228.011 175.242 257.897 111.386 210.241 160.983 191.196 250.928 63.1328 126.583 110.688 149.879 115.633 112.024 104.669 45.7908 197.96 204.687 87.113 137.78 167.053 99.3476 165.661 153.555 190.602 375.883 141.372 208.18 209.444 97.8965 157.28 85.8756 163.609 115.338 189.943 371.534 78.6539 163.265 131.109 214.426 151.186 106.665 71.0454 64.8464 202.745 100.439 264.677 293.651 214.281 155.954
RI PT
160.28 119.151 187.087 141.828 190.583 120.098 204.099 129.167 85.6791 150.038 261.905 77.306 202.019 145.626 208.807 100.99 178.917 127.204 182.01 240.698 53.4245 105.203 94.6186 134.586 105.932 103.837 97.9827 36.1835 176.628 170.773 82.1235 95.8268 145.449 85.6778 126.335 148.281 154.875 332.766 122.834 203.423 207.698 87.4921 136.912 63.6822 146.691 98.1171 161.932 316.297 73.5045 169.068 121.199 168.085 172.045 103.369 124.208 56.5543 182.725 85.2608 229.928 336.611 259.585 141.114
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
Entpd6 Ripk2 Tmem263 Agt Bet1 Rabep2 Nfkb2 Znf830 Lcmt1 Coa6 Aamp Ash2l
TE D
Zcchc24 Obfc1 Stx6 Phpt1 Scyl2 Ccdc127 Mrpl20 Ppp2r5c Praf2 Mcl1 Anapc5 Ptk2b Nars2 Txnrd3 Ppp2ca
BCL9L_MOUSE B-cell CLL/lymphoma 9-like protein SLMAP_MOUSE Sarcolemmal membrane-associated protein RTN3_MOUSE Reticulon-3 CHMP7_MOUSE Charged multivesicular body protein 7 GNL3_MOUSE Guanine nucleotide-binding protein-like 3 SNP47_MOUSE Synaptosomal-associated protein 47 DCTN4_MOUSE Dynactin subunit 4 PTER_MOUSE Phosphotriesterase-related protein WDR44_MOUSE WD repeat-containing protein 44 STK4_MOUSE Serine/threonine-protein kinase 4 OSBL9_MOUSE Oxysterol-binding protein-related protein 9 SH3L1_MOUSE SH3 domain-binding glutamic acid-rich-like protein CC033_MOUSE Protein C3orf33 homolog ZCH24_MOUSE Zinc finger CCHC domain-containing protein 24 STN1_MOUSE CST complex subunit STN1 STX6_MOUSE Syntaxin-6 PHP14_MOUSE 14 kDa phosphohistidine phosphatase SCYL2_MOUSE SCY1-like protein 2 CC127_MOUSE Coiled-coil domain-containing protein 127 RM20_MOUSE 39S ribosomal protein L20, mitochondrial 2A5G_MOUSE Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform PRAF2_MOUSE PRA1 family protein 2 MCL1_MOUSE Induced myeloid leukemia cell differentiation protein Mcl-1 homolog APC5_MOUSE Anaphase-promoting complex subunit 5 FAK2_MOUSE Protein-tyrosine kinase 2-beta SYNM_MOUSE Probable asparagine--tRNA ligase, mitochondrial TRXR3_MOUSE Thioredoxin reductase 3 PP2AA_MOUSE Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform DIA1_MOUSE Deleted in autism protein 1 homolog Q3U0P5_MOUSE Ectonucleoside triphosphate diphosphohydrolase 6, isoform CRA_a RIPK2_MOUSE Receptor-interacting serine/threonine-protein kinase 2 TM263_MOUSE Transmembrane protein 263 ANGT_MOUSE Angiotensinogen BET1_MOUSE BET1 homolog RABE2_MOUSE Rab GTPase-binding effector protein 2 NFKB2_MOUSE Nuclear factor NF-kappa-B p100 subunit ZN830_MOUSE Zinc finger protein 830 A2RTH5_MOUSE Leucine carboxyl methyltransferase 1 COA6_MOUSE Cytochrome c oxidase assembly factor 6 homolog J3QN89_MOUSE Protein Aamp ASH2L_MOUSE Set1/Ash2 histone methyltransferase complex subunit ASH2 CH037_MOUSE Protein C8orf37 homolog CACL1_MOUSE CDK2-associated and cullin domain-containing protein 1 ASPG_MOUSE N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase 5NTC_MOUSE Cytosolic purine 5'-nucleotidase NUDT4_MOUSE Diphosphoinositol polyphosphate phosphohydrolase 2 RAVR1_MOUSE Ribonucleoprotein PTB-binding 1 IF3M_MOUSE Translation initiation factor IF-3, mitochondrial OXSM_MOUSE 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial CTR9_MOUSE RNA polymerase-associated protein CTR9 homolog VLDLR_MOUSE Very low-density lipoprotein receptor SPAG7_MOUSE Sperm-associated antigen 7 FARP2_MOUSE FERM, RhoGEF and pleckstrin domain-containing protein 2 TARA_MOUSE TRIO and F-actin-binding protein RL37A_MOUSE 60S ribosomal protein L37a PRPS2_MOUSE Ribose-phosphate pyrophosphokinase 2 FYCO1_MOUSE FYVE and coiled-coil domain-containing protein 1 ZC3H4_MOUSE Zinc finger CCCH domain-containing protein 4 AAMDC_MOUSE Mth938 domain-containing protein SSRD_MOUSE Translocon-associated protein subunit delta CARM1_MOUSE Histone-arginine methyltransferase CARM1 GGA2_MOUSE ADP-ribosylation factor-binding protein GGA2
EP
Bcl9l Slmap Rtn3 Chmp7 Gnl3 Snap47 Dctn4 Pter Wdr44 Stk4 Osbpl9 Sh3bgrl
AC C
sp|Q67FY2|BCL9L_MOUSE sp|Q3URD3|SLMAP_MOUSE sp|Q9ES97|RTN3_MOUSE sp|Q8R1T1|CHMP7_MOUSE sp|Q8CI11|GNL3_MOUSE sp|Q8R570|SNP47_MOUSE sp|Q8CBY8|DCTN4_MOUSE sp|Q60866|PTER_MOUSE sp|Q6NVE8|WDR44_MOUSE sp|Q9JI11|STK4_MOUSE sp|A2A8Z1|OSBL9_MOUSE sp|Q9JJU8|SH3L1_MOUSE sp|Q8BN57|CC033_MOUSE sp|B2RVL6|ZCH24_MOUSE sp|Q8K2X3|STN1_MOUSE sp|Q9JKK1|STX6_MOUSE sp|Q9DAK9|PHP14_MOUSE sp|Q8CFE4|SCYL2_MOUSE sp|Q3TC33|CC127_MOUSE sp|Q9CQL4|RM20_MOUSE sp|Q60996|2A5G_MOUSE sp|Q9JIG8|PRAF2_MOUSE sp|P97287|MCL1_MOUSE sp|Q8BTZ4|APC5_MOUSE sp|Q9QVP9|FAK2_MOUSE sp|Q8BGV0|SYNM_MOUSE sp|Q99MD6|TRXR3_MOUSE sp|P63330|PP2AA_MOUSE sp|Q3USZ8|DIA1_MOUSE tr|Q3U0P5|Q3U0P5_MOUSE sp|P58801|RIPK2_MOUSE sp|Q9DAM7|TM263_MOUSE sp|P11859|ANGT_MOUSE sp|O35623|BET1_MOUSE sp|Q91WG2|RABE2_MOUSE sp|Q9WTK5|NFKB2_MOUSE sp|Q8R1N0|ZN830_MOUSE tr|A2RTH5|A2RTH5_MOUSE sp|Q8BGD8|COA6_MOUSE tr|J3QN89|J3QN89_MOUSE sp|Q91X20|ASH2L_MOUSE sp|Q3UJP5|CH037_MOUSE sp|Q8R0X2|CACL1_MOUSE sp|Q64191|ASPG_MOUSE sp|Q3V1L4|5NTC_MOUSE sp|Q8R2U6|NUDT4_MOUSE sp|Q9CW46|RAVR1_MOUSE sp|Q9CZD5|IF3M_MOUSE sp|Q9D404|OXSM_MOUSE sp|Q62018|CTR9_MOUSE sp|P98156|VLDLR_MOUSE sp|Q7TNE3|SPAG7_MOUSE sp|Q91VS8|FARP2_MOUSE sp|Q99KW3|TARA_MOUSE sp|P61514|RL37A_MOUSE sp|Q9CS42|PRPS2_MOUSE sp|Q8VDC1|FYCO1_MOUSE sp|Q6ZPZ3|ZC3H4_MOUSE sp|Q8R0P4|AAMDC_MOUSE sp|Q62186|SSRD_MOUSE sp|Q9WVG6|CARM1_MOUSE sp|Q6P5E6|GGA2_MOUSE
168.459 113.011 194.168 133.645 228.652 113.949 184.503 114.178 73.9894 138.159 226.29 58.0411 171.401 133.021 189.507 91.334 186.199 128.768 196.614 246.701 53.996 101.036 98.3868 129.926 98.7277 109.148 90.7957 33.9682 170.848 137.484 79.0198 106.94 115.186 81.6075 124.389 115.769 181.513 274.385 105.377 276.139 229.019 94.708 122.352 50.9197 115.283 87.4317 132.441 289.646 79.8808 171.866 137.657 169.513 188.997 114.395 190.701 62.9437 156.25 84.1943 196.863 391.485 273.59 109.236
158.579 98.2891 192.539 122.376 419.741 86.0101 240.389 103.192 65.468 136.608 211.755 606.707 127.603 145.965 237.889 88.8268 100.341 190.582 249.242 119.964 545.701 139.603 80.7373 101.49 169.941 171.934 197.111 565.81 127.543 178.881 71.02 115.953 34.0573 142.104 112.571 140.46 94.2001 319.575 61.2643 161.901 181.386 43.5421 130.656 38.5865 66.4581 56.4641 168.015 157.15 258.354 228.775 210.379 112.264 169.629 107.557 244.359 201.693 242.677 72.5133 82.0332 412.168 239.78 88.7046
200.286 158.237 166.407 118.978 336.567 93.6001 222.749 113.918 147.089 147.549 389.19 1460.59 150.531 349.954 192.835 154.563 227.548 176.62 132.77 194.588 595.64 82.3842 88.5649 94.8008 222.219 206.888 118.49 709.462 97.9663 214.67 72.0446 201.617 105.687 101.82 214.785 133.989 180.96 311.02 192.624 352.823 242.002 98.1249 110.086 66.8492 100.241 153.549 227.426 388.991 257.611 164.501 175.733 317.429 153.379 169.335 179.325 178.957 279.448 146.249 260.443 288.824 188.925 135.296
1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.03 1.03 1.03 1.03
1.06 1.07 1.00 0.88 1.88 0.80 1.19 0.96 1.33 0.97 1.25 13.43 0.75 1.72 1.03 1.28 0.88 1.35 1.05 0.67 10.39 1.04 0.86 0.75 1.95 1.82 1.72 17.00 0.65 1.22 0.91 1.38 0.52 1.42 1.19 1.08 0.78 1.02 1.08 1.12 1.01 0.77 0.90 0.81 0.63 1.09 1.28 0.86 3.40 1.23 1.50 1.16 0.99 1.30 1.68 3.09 1.51 1.23 0.77 1.06 0.91 0.87
ACCEPTED MANUSCRIPT
TE D
106.404 92.9848 173.138 130.293 180.95 64.7292 95.0562 238.727 185.307 169.134 139.692 120.994 292.102 107.575 189.774 120.77 212.699 164.805 117.881 158.411 69.6387 120.906 179.38 131.329 118.229 123.562 190.499 96.2127 174.446 349.551 168.486 133.823 177.964 403.885 247.393 174.553 170.523 135.194 154.268 175.745 186.708 196.28 127.216 193.008 71.4641 162.137 269.667 123.732 179.478 82.3216 163.749 168.098 188.285 99.7295 116.683 161.338 118.562 180.067 147.047 87.698 106.207 221.679
130.627 79.719 194.225 109.866 211.208 68.9605 113.913 290.692 226.487 135.756 148.434 140.481 292.072 144.906 208.455 117.207 229.808 163.657 96.7711 183.905 76.7881 144.438 216.297 123.491 127.87 131.497 220.223 114.752 190.885 365.348 159.879 141.997 197.441 437.203 220.233 199.094 158.418 140.47 160.965 181.901 152.059 203.481 134.062 197.459 64.8355 190.605 255.579 122.797 103.901 97.4645 192.581 156.579 199.319 104.432 134.182 154.565 132.39 189.047 150.981 72.3891 84.3453 237.253
RI PT
123.31 85.9605 155.699 119.189 184.313 66.7355 89.7287 269.57 230.721 140.045 127.84 137.271 282.701 131.158 207.932 124.119 196.667 142.967 96.5428 164.139 66.0281 127.259 197.15 143.052 121.048 119.858 216.932 111.134 183.481 311.857 149.485 120.539 176.601 422.34 255.078 183.801 151.604 125.914 146.118 168.907 140.574 212.243 121.228 176.849 51.0612 206.163 273.55 115.206 115.416 111.317 189.06 147.54 191.802 93.2708 140.28 172.874 128.603 176.673 157.756 67.398 91.3049 282.638
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
MACD1_MOUSE O-acetyl-ADP-ribose deacetylase MACROD1 KC1A_MOUSE Casein kinase I isoform alpha Q6XLQ8_MOUSE Calumenin CSN8_MOUSE COP9 signalosome complex subunit 8 DCUP_MOUSE Uroporphyrinogen decarboxylase CC115_MOUSE Coiled-coil domain-containing protein 115 D3Z0Y2_MOUSE Peroxiredoxin-6 PI42C_MOUSE Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma SC24A_MOUSE Protein transport protein Sec24A PSMG2_MOUSE Proteasome assembly chaperone 2 AFTIN_MOUSE Aftiphilin PTH2_MOUSE Peptidyl-tRNA hydrolase 2, mitochondrial MYO6_MOUSE Unconventional myosin-VI ACL6A_MOUSE Actin-like protein 6A RM14_MOUSE 39S ribosomal protein L14, mitochondrial 2A5E_MOUSE Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform COXM1_MOUSE COX assembly mitochondrial protein homolog CLIP2_MOUSE CAP-Gly domain-containing linker protein 2 RIC1_MOUSE Protein RIC1 homolog KI13A_MOUSE Kinesin-like protein KIF13A MED8_MOUSE Mediator of RNA polymerase II transcription subunit 8 SRSF4_MOUSE Serine/arginine-rich splicing factor 4 DLP1_MOUSE Decaprenyl-diphosphate synthase subunit 2 SAC1_MOUSE Phosphatidylinositide phosphatase SAC1 NUDT3_MOUSE Diphosphoinositol polyphosphate phosphohydrolase 1 ERLEC_MOUSE Endoplasmic reticulum lectin 1 SPS1_MOUSE Selenide, water dikinase 1 COMD7_MOUSE COMM domain-containing protein 7 SEPT5_MOUSE Septin-5 RWDD1_MOUSE RWD domain-containing protein 1 NCOR1_MOUSE Nuclear receptor corepressor 1 ATF7_MOUSE Cyclic AMP-dependent transcription factor ATF-7 RBM10_MOUSE RNA-binding protein 10 NAA10_MOUSE N-alpha-acetyltransferase 10 SPCS3_MOUSE Signal peptidase complex subunit 3 SMAP1_MOUSE Stromal membrane-associated protein 1 UB2R2_MOUSE Ubiquitin-conjugating enzyme E2 R2 BICD2_MOUSE Protein bicaudal D homolog 2 DCTP1_MOUSE dCTP pyrophosphatase 1 NCK1_MOUSE Cytoplasmic protein NCK1 NCOR2_MOUSE Nuclear receptor corepressor 2 DYLT1_MOUSE Dynein light chain Tctex-type 1 CREB1_MOUSE Cyclic AMP-responsive element-binding protein 1 ZC3HE_MOUSE Zinc finger CCCH domain-containing protein 14 EIF2D_MOUSE Eukaryotic translation initiation factor 2D ILVBL_MOUSE Acetolactate synthase-like protein SCAF8_MOUSE Protein SCAF8 CC124_MOUSE Coiled-coil domain-containing protein 124 LTOR5_MOUSE Ragulator complex protein LAMTOR5 RMND1_MOUSE Required for meiotic nuclear division protein 1 homolog Q8CIH9_MOUSE Amidophosphoribosyltransferase RM46_MOUSE 39S ribosomal protein L46, mitochondrial SYDM_MOUSE Aspartate--tRNA ligase, mitochondrial PCM1_MOUSE Pericentriolar material 1 protein Q3ULW8_MOUSE Protein Parp3 UBP38_MOUSE Ubiquitin carboxyl-terminal hydrolase 38 TPM2_MOUSE Tropomyosin beta chain TOX4_MOUSE TOX high mobility group box family member 4 FAD1_MOUSE FAD synthase RS26_MOUSE 40S ribosomal protein S26 FHOD1_MOUSE FH1/FH2 domain-containing protein 1 SYFM_MOUSE Phenylalanine--tRNA ligase, mitochondrial
EP
Macrod1 Csnk1a1 Calu Cops8 Urod Ccdc115 Prdx6 Pip4k2c Sec24a Psmg2 Aftph Ptrh2 Myo6 Actl6a Mrpl14 Ppp2r5e Cmc1 Clip2 Kiaa1432 Kif13a Med8 Srsf4 Pdss2 Sacm1l Nudt3 Erlec1 Sephs1 Commd7 05-Sep Rwdd1 Ncor1 Atf7 Rbm10 Naa10 Spcs3 Smap1 Ube2r2 Bicd2 Dctpp1 Nck1 Ncor2 Dynlt1 Creb1 Zc3h14 Eif2d Ilvbl Scaf8 Ccdc124 Lamtor5 Rmnd1 Ppat Mrpl46 Dars2 Pcm1 Parp3 Usp38 Tpm2 Tox4 Flad1 Rps26 Fhod1 Fars2
AC C
sp|Q922B1|MACD1_MOUSE sp|Q8BK63|KC1A_MOUSE tr|Q6XLQ8|Q6XLQ8_MOUSE sp|Q8VBV7|CSN8_MOUSE sp|P70697|DCUP_MOUSE sp|Q8VE99|CC115_MOUSE tr|D3Z0Y2|D3Z0Y2_MOUSE sp|Q91XU3|PI42C_MOUSE sp|Q3U2P1|SC24A_MOUSE sp|Q9EST4|PSMG2_MOUSE sp|Q80WT5|AFTIN_MOUSE sp|Q8R2Y8|PTH2_MOUSE sp|Q64331|MYO6_MOUSE sp|Q9Z2N8|ACL6A_MOUSE sp|Q9D1I6|RM14_MOUSE sp|Q61151|2A5E_MOUSE sp|Q9CPZ8|COXM1_MOUSE sp|Q9Z0H8|CLIP2_MOUSE sp|Q69ZJ7|RIC1_MOUSE sp|Q9EQW7|KI13A_MOUSE sp|Q9D7W5|MED8_MOUSE sp|Q8VE97|SRSF4_MOUSE sp|Q33DR3|DLP1_MOUSE sp|Q9EP69|SAC1_MOUSE sp|Q9JI46|NUDT3_MOUSE sp|Q8VEH8|ERLEC_MOUSE sp|Q8BH69|SPS1_MOUSE sp|Q8BG94|COMD7_MOUSE sp|Q9Z2Q6|SEPT5_MOUSE sp|Q9CQK7|RWDD1_MOUSE sp|Q60974|NCOR1_MOUSE sp|Q8R0S1|ATF7_MOUSE sp|Q99KG3|RBM10_MOUSE sp|Q9QY36|NAA10_MOUSE sp|Q9D365|SPCS3_MOUSE sp|Q91VZ6|SMAP1_MOUSE sp|Q6ZWZ2|UB2R2_MOUSE sp|Q921C5|BICD2_MOUSE sp|Q9QY93|DCTP1_MOUSE sp|Q99M51|NCK1_MOUSE sp|Q9WU42|NCOR2_MOUSE sp|P51807|DYLT1_MOUSE sp|Q01147|CREB1_MOUSE sp|Q8BJ05|ZC3HE_MOUSE sp|Q61211|EIF2D_MOUSE sp|Q8BU33|ILVBL_MOUSE sp|Q6DID3|SCAF8_MOUSE sp|Q9D8X2|CC124_MOUSE sp|Q9D1L9|LTOR5_MOUSE sp|Q8CI78|RMND1_MOUSE tr|Q8CIH9|Q8CIH9_MOUSE sp|Q9EQI8|RM46_MOUSE sp|Q8BIP0|SYDM_MOUSE sp|Q9R0L6|PCM1_MOUSE tr|Q3ULW8|Q3ULW8_MOUSE sp|Q8BW70|UBP38_MOUSE sp|P58774|TPM2_MOUSE sp|Q8BU11|TOX4_MOUSE sp|Q8R123|FAD1_MOUSE sp|P62855|RS26_MOUSE sp|Q6P9Q4|FHOD1_MOUSE sp|Q99M01|SYFM_MOUSE
105.355 104.03 143.245 145.705 162.922 65.5684 74.7166 227.883 197.718 179.427 123.724 121.661 291.249 97.3457 193.845 130.467 183.584 146.386 119.184 140.814 59.5353 104.817 161.886 151.883 111.946 111.96 184.718 90.4427 162.594 286.171 153.147 108.144 150.96 373.817 272.817 152.226 157.385 114.91 132.771 155.043 167.786 195.412 108.503 162.641 54.1735 166.8 271.523 109.038 182.089 90.2415 148.524 148.323 167.529 81.4156 113.234 166.75 104.594 152.946 141.053 75.8144 102.775 240.502
291.926 72.1023 141.166 120.793 167.047 105.544 63.8858 194.417 356.107 487.626 102.467 151.026 345.634 113.859 106.219 98.0145 141.485 155.556 136.927 147.261 53.4406 69.1408 168.94 112.688 94.1985 79.7654 191.601 84.0298 143.391 284.347 143.313 121.06 245.782 420.828 248.023 112.265 132.676 116.937 25.6016 121.436 176.338 172.596 181.303 111.622 306.017 146.484 382.914 122.071 75.9225 181.95 277.121 73.1037 144.384 47.8766 88.0256 99.8903 522.963 113.838 273.385 215.031 191.936 172.771
610.326 61.6031 238.011 245.121 204.754 244.423 142.813 291.098 323.162 411.693 219.328 162.2 343.615 105.253 223.641 99.286 519.21 386.934 119.356 186.778 112.286 178.455 188.848 126.743 143.956 147.33 273.306 68.0135 155.123 489.446 394.468 250.09 584.57 530.416 256.186 118.379 278.212 217.61 177.267 197.881 471.706 227.099 295.383 212.077 365.318 115.771 418.171 179.414 463.484 107.006 205.542 164.854 215.481 90.3435 93.4762 122.088 844.332 217.226 287.081 280.857 167.238 231.125
1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.00 1.00 1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.95 0.95
3.93 0.75 1.15 1.47 1.02 2.66 1.12 0.96 1.63 2.91 1.20 1.21 1.20 0.92 0.83 0.81 1.61 1.76 1.20 1.04 1.22 1.00 0.95 0.87 1.00 0.93 1.14 0.73 0.83 1.17 1.69 1.46 2.34 1.15 1.00 0.64 1.28 1.28 0.68 0.93 1.98 0.98 1.92 0.88 5.48 0.71 1.47 1.26 1.83 1.49 1.37 0.75 0.95 0.72 0.71 0.66 5.53 0.93 1.84 3.20 1.82 0.80
ACCEPTED MANUSCRIPT
Enoph1 Polr2e Cln5 Ctif Msi2 Ltbp3 Vamp3 Pcmtd1 Ppp6c Ubr7 Anapc4 Ankrd44 Strn4 Ap1s1 Rtf1 Srek1 Rilpl1
TE D
122.351 185.319 126.643 156.198 64.8979 275.441 299.37 298.203 204.125 194.035 228.369 92.8944 109.635 191.14 198.829 157.097 68.8346 132.93 227.649 210.746 226.326 137.341 294.209 172.05 176.935 149.554 193.059 160.288 139.789 229.867 201.274 159.343 195.688 141.224 130.196 147.58 110.91 176.024 109.882 254.573 105.919 264.133 166.813 134.116 230.905 158.067 160.459 229.993 254.15 171.924 169.13 121.79 225.691 171.451 175.524 131.27 127.213 146.851 126.614 158.529 117.127 251.261
129.999 135.918 114.652 149.554 63.0223 341.036 180.014 310.582 224.123 204.292 248.362 110.924 116.227 151.65 213.28 113.793 64.9699 116.391 227.209 215.21 220.397 146.174 261.023 158.459 195.719 149.09 187.842 151.715 137.77 170.387 194.601 164.439 216.336 196.358 146.816 153.517 113.36 172.79 98.9374 262.846 121.189 230.981 156.696 139.144 223.831 172.833 136.278 224.172 227.003 144.663 142.33 119.75 241.243 178.144 149.493 100.151 128.493 133.765 97.0202 168.554 113.446 264.472
RI PT
131.075 157.082 102.529 138.057 62.2657 348.372 301.416 305.401 213.184 219.752 216.819 111.071 126.438 187.998 198.894 102.69 62.111 140.934 206.384 201.689 204.506 137.877 289.693 187.001 189.92 162.137 174.354 140.595 136.942 147.636 173.618 176.357 227.83 219.673 146.538 187.71 131.69 187.635 132.199 265.471 129.877 244.923 159.547 160.238 224.989 212.98 165.502 337.943 263.504 179.838 141.074 126.716 273.061 216.825 157.345 136.716 136.788 136.221 147.011 175.895 123.26 293.126
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
M AN U
ARFP2_MOUSE Arfaptin-2 VPS53_MOUSE Vacuolar protein sorting-associated protein 53 homolog PHAX_MOUSE Phosphorylated adapter RNA export protein KLC4_MOUSE Kinesin light chain 4 TNG2_MOUSE Transport and Golgi organization 2 homolog ANX11_MOUSE Annexin A11 EDNRA_MOUSE Endothelin-1 receptor ZCHC8_MOUSE Zinc finger CCHC domain-containing protein 8 DDI2_MOUSE Protein DDI1 homolog 2 YTHD1_MOUSE YTH domain-containing family protein 1 CBX5_MOUSE Chromobox protein homolog 5 PITH1_MOUSE PITH domain-containing protein 1 PDCD6_MOUSE Programmed cell death protein 6 SURF4_MOUSE Surfeit locus protein 4 OLM2B_MOUSE Olfactomedin-like protein 2B GBRL2_MOUSE Gamma-aminobutyric acid receptor-associated protein-like 2 CHCH2_MOUSE Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial GNAO_MOUSE Isoform Alpha-2 of Guanine nucleotide-binding protein G(o) subunit alpha FL2D_MOUSE Pre-mRNA-splicing regulator WTAP ASUN_MOUSE Protein asunder homolog FRG1_MOUSE Protein FRG1 COMD9_MOUSE COMM domain-containing protein 9 M4K4_MOUSE Mitogen-activated protein kinase kinase kinase kinase 4 TPPC4_MOUSE Trafficking protein particle complex subunit 4 K0907_MOUSE UPF0469 protein KIAA0907 GABPA_MOUSE GA-binding protein alpha chain MAT1_MOUSE CDK-activating kinase assembly factor MAT1 RYBP_MOUSE RING1 and YY1-binding protein RBM33_MOUSE RNA-binding protein 33 PRC2B_MOUSE Protein PRRC2B MKL2_MOUSE MKL/myocardin-like protein 2 B1ATE0_MOUSE Protein Sgsh MARE3_MOUSE Microtubule-associated protein RP/EB family member 3 FOXK1_MOUSE Forkhead box protein K1 KATL1_MOUSE Katanin p60 ATPase-containing subunit A-like 1 MK14_MOUSE Mitogen-activated protein kinase 14 GTPC1_MOUSE Putative GTP cyclohydrolase 1 type 2 Nif3l1 CRADD_MOUSE Death domain-containing protein CRADD NFIX_MOUSE Nuclear factor 1 X-type BAZ2A_MOUSE Bromodomain adjacent to zinc finger domain protein 2A PPIL1_MOUSE Peptidyl-prolyl cis-trans isomerase-like 1 VP37A_MOUSE Vacuolar protein sorting-associated protein 37A RBM27_MOUSE RNA-binding protein 27 GGH_MOUSE Gamma-glutamyl hydrolase CQ085_MOUSE Uncharacterized protein C17orf85 homolog ENOPH_MOUSE Enolase-phosphatase E1 RPAB1_MOUSE DNA-directed RNA polymerases I, II, and III subunit RPABC1 CLN5_MOUSE Ceroid-lipofuscinosis neuronal protein 5 homolog CTIF_MOUSE CBP80/20-dependent translation initiation factor MSI2H_MOUSE RNA-binding protein Musashi homolog 2 LTBP3_MOUSE Latent-transforming growth factor beta-binding protein 3 VAMP3_MOUSE Vesicle-associated membrane protein 3 PCMD1_MOUSE Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 PPP6_MOUSE Serine/threonine-protein phosphatase 6 catalytic subunit UBR7_MOUSE Putative E3 ubiquitin-protein ligase UBR7 APC4_MOUSE Anaphase-promoting complex subunit 4 ANR44_MOUSE Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B STRN4_MOUSE Striatin-4 AP1S1_MOUSE AP-1 complex subunit sigma-1A RTF1_MOUSE RNA polymerase-associated protein RTF1 homolog SREK1_MOUSE Splicing regulatory glutamine/lysine-rich protein 1 RIPL1_MOUSE RILP-like protein 1
EP
Arfip2 Vps53 Phax Klc4 Tango2 Anxa11 Ednra Zcchc8 Ddi2 Ythdf1 Cbx5 Pithd1 Pdcd6 Surf4 Olfml2b Gabarapl2 Chchd2 Gnao1 Wtap Asun Frg1 Commd9 Map4k4 Trappc4 Kiaa0907 Gabpa Mnat1 Rybp Rbm33 Prrc2b Mkl2 Sgsh Mapre3 Foxk1 Katnal1 Mapk14 Nif3l1 Cradd Nfix Baz2a Ppil1 Vps37a Rbm27 Ggh
AC C
sp|Q8K221|ARFP2_MOUSE sp|Q8CCB4|VPS53_MOUSE sp|Q9JJT9|PHAX_MOUSE sp|Q9DBS5|KLC4_MOUSE sp|P54797|TNG2_MOUSE sp|P97384|ANX11_MOUSE sp|Q61614|EDNRA_MOUSE sp|Q9CYA6|ZCHC8_MOUSE sp|A2ADY9|DDI2_MOUSE sp|P59326|YTHD1_MOUSE sp|Q61686|CBX5_MOUSE sp|Q8BWR2|PITH1_MOUSE sp|P12815|PDCD6_MOUSE sp|Q64310|SURF4_MOUSE sp|Q3V1G4|OLM2B_MOUSE sp|P60521|GBRL2_MOUSE sp|Q9D1L0|CHCH2_MOUSE sp|P18872-2|GNAO_MOUSE sp|Q9ER69|FL2D_MOUSE sp|Q8QZV7|ASUN_MOUSE sp|P97376|FRG1_MOUSE sp|Q8K2Q0|COMD9_MOUSE sp|P97820|M4K4_MOUSE sp|Q9ES56|TPPC4_MOUSE sp|Q3TCX3|K0907_MOUSE sp|Q00422|GABPA_MOUSE sp|P51949|MAT1_MOUSE sp|Q8CCI5|RYBP_MOUSE sp|Q9CXK9|RBM33_MOUSE sp|Q7TPM1|PRC2B_MOUSE sp|P59759|MKL2_MOUSE tr|B1ATE0|B1ATE0_MOUSE sp|Q6PER3|MARE3_MOUSE sp|P42128|FOXK1_MOUSE sp|Q8K0T4|KATL1_MOUSE sp|P47811|MK14_MOUSE sp|Q9EQ80|GTPC1_MOUSE sp|O88843|CRADD_MOUSE sp|P70257|NFIX_MOUSE sp|Q91YE5|BAZ2A_MOUSE sp|Q9D0W5|PPIL1_MOUSE sp|Q8CHS8|VP37A_MOUSE sp|Q5SFM8|RBM27_MOUSE sp|Q9Z0L8|GGH_MOUSE sp|Q8BZR9|CQ085_MOUSE sp|Q8BGB7|ENOPH_MOUSE sp|Q80UW8|RPAB1_MOUSE sp|Q3UMW8|CLN5_MOUSE sp|Q6PEE2|CTIF_MOUSE sp|Q920Q6|MSI2H_MOUSE sp|Q61810|LTBP3_MOUSE sp|P63024|VAMP3_MOUSE sp|P59913|PCMD1_MOUSE sp|Q9CQR6|PPP6_MOUSE sp|Q8BU04|UBR7_MOUSE sp|Q91W96|APC4_MOUSE sp|B2RXR6|ANR44_MOUSE sp|P58404|STRN4_MOUSE sp|P61967|AP1S1_MOUSE sp|A2AQ19|RTF1_MOUSE sp|Q8BZX4|SREK1_MOUSE sp|Q9JJC6|RIPL1_MOUSE
110.052 187.835 101.867 128.364 57.0281 247.383 386.556 258.607 169.262 185.394 170.188 80.7067 105.403 202.009 157.694 128.478 56.8805 138.366 176.073 167.272 178.748 108.75 279.794 173.757 142.976 138.106 150.526 124.5 116.266 174.777 146.956 140.984 168.79 131.08 104.235 149.459 105.699 155.54 119.099 202.452 89.4944 222.98 133.138 122.176 179.525 155.427 151.778 277.387 229.653 165.311 130.822 98.7588 196.253 162.379 139.27 131.633 99.2057 110.38 138.796 119.519 93.3596 203.581
106.72 187.282 131.735 205.889 45.8642 169.065 216.755 274.289 245.152 341.125 84.4109 106.125 153.907 248.853 83.261 140.118 93.7221 293.068 93.0352 131.126 267.978 102.549 300.007 149.691 132.384 149.399 133.123 152.971 88.372 65.4166 96.4865 120.279 184.343 180.827 393.114 129.236 167.038 102.158 401.538 629.544 102.796 178.432 186.212 100.188 144.86 163.267 174.071 159.84 225.386 163.497 100.34 103.342 139.171 171.589 93.2703 97.0225 165.979 110.864 120.596 155.384 77.5889 180.276
102.491 149.96 473.451 281.166 81.2202 176.042 201.715 380.107 414.54 517.924 150.645 83.3106 123.718 174.521 308.252 268.265 125.853 304.65 189.641 170.685 395.151 120.672 529.092 147.84 185.395 223.463 203.877 366.68 211.935 151.273 133.324 220.92 208.64 165.026 423.42 155.118 151.874 162.313 209.66 575.993 144.317 442.689 347.811 108.076 261.05 130.308 207.3 114.478 273.711 283.656 304.292 86.4612 232.216 283.419 188.121 97.6634 123.632 222.108 141.115 236.26 167.109 353.205
0.95 0.95 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.92 0.92 0.92 0.92 0.92 0.91 0.91 0.91 0.91 0.91 0.91 0.90 0.90 0.90 0.90 0.89 0.89 0.89 0.89 0.89 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.87 0.86 0.86 0.86 0.86 0.86 0.86 0.86
0.83 0.98 2.64 1.66 1.00 0.55 0.70 1.08 1.58 2.08 0.53 0.93 1.18 1.12 0.98 1.57 1.68 2.18 0.65 0.73 1.54 0.81 1.42 0.83 0.87 1.20 0.92 1.73 1.09 0.57 0.61 1.02 0.93 0.96 2.95 0.85 1.31 0.73 2.52 2.32 1.05 1.22 1.64 0.71 0.89 0.79 1.17 0.48 0.96 1.27 1.30 0.76 0.74 1.17 0.85 0.73 1.10 1.18 0.96 1.17 1.02 0.98
ACCEPTED MANUSCRIPT
150.999 151.146 138.572 199.444 140.642 134.394 176.484 100.654 298.798 173.833 163.463 214.47 122.462 120.803 199.832 87.8692 217.821 143.191 129.34 134.326 142.176 214.287 163.954 150.023 205.134 257.219 145.997 258.561 162.486 110.971 227.022 231.245 294.752 42.1021 52.905 50.7711 41.4124 66.4355 37.6802 81.211 49.1506 56.0379 60.9577 10.942 43.5787 74.1725 55.1563 89.7464 15.5924 65.0486 77.5169 76.1826 70.4816 76.6657 55.0244 56.4139 249.32 70.0003 72.827 33.2513 69.5074 118.389
96.5095 118.976 141.334 184.869 134.798 106.808 174.676 54.9844 280.425 112.894 148.34 184.864 103.117 45.7544 207.779 54.2372 182.196 99.2238 137.646 126.416 106.095 156.53 110.725 98.8423 155.333 177.627 73.1054 117.262 176.439 69.431 115.376 93.2409 136.322 168.166 226.203 143.683 119.83 149.577 116.245 97.9356 78.8973 112.801 129.083 31.1147 123.583 166.128 108.929 151.501 35.2287 241.468 155.277 155.214 75.8418 162.673 94.2495 124.544 513.465 144.875 139.09 62.0181 162.753 262.961
RI PT
184.253 133.652 173.504 196.285 144.058 112.533 182.797 128.99 369.909 115.359 168.316 186.368 117.734 46.3485 248.463 110.98 217.178 96.0629 166.698 178.122 124.24 216.192 190.974 173.998 341.49 304.182 142.81 219.795 259.618 104.989 331.835 261.217 248.273 44.9139 69.0753 42.9761 46.1868 26.8944 54.8877 52.75 55.9465 42.8985 55.7844 16.3633 35.0756 88.0091 48.0402 72.5215 21.485 129.317 70.2717 93.0771 32.1368 75.976 54.1844 66.6667 226.33 77.4168 79.5119 37.2385 93.5414 148.893
SC
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
TE D
Znf706 Mdm2 Ankzf1 Tmem14c Polr2g Zfand5 Nudt17 Casp6 Rsrc2 Cmbl Ap2s1 Gnb1 Mtatp8 Rtn4 Elp2 Bnip3l Akr7a2 Ifi30 Fntb Slc35e3 Crip1 Serpina3g Akr1c13 Tagln Ncam1 H2afx Anpep Sap18 Tmem176b Fdft1 Cxcl12 Ptgs1 Des Fads2 Gstm7 Sqle Prodh Hba Ca13 Mettl15 Apoa1 Apoo S100g Dock5 Surf6 Rala Ptgis F11r Sfxn2 Slc5a6
ORNT1_MOUSE Mitochondrial ornithine transporter 1 RTF2_MOUSE Protein RTF2 homolog NPS3B_MOUSE Protein NipSnap homolog 3B GCC2_MOUSE GRIP and coiled-coil domain-containing protein 2 CCD22_MOUSE Coiled-coil domain-containing protein 22 ARHG7_MOUSE Rho guanine nucleotide exchange factor 7 FCGRN_MOUSE IgG receptor FcRn large subunit p51 NU1M_MOUSE NADH-ubiquinone oxidoreductase chain 1 BPNT1_MOUSE 3'(2'),5'-bisphosphate nucleotidase 1 CACO1_MOUSE Calcium-binding and coiled-coil domain-containing protein 1 S100B_MOUSE Protein S100-B CR025_MOUSE Uncharacterized protein C18orf25 homolog ZN706_MOUSE Zinc finger protein 706 MDM2_MOUSE E3 ubiquitin-protein ligase Mdm2 ANKZ1_MOUSE Ankyrin repeat and zinc finger domain-containing protein 1 TM14C_MOUSE Transmembrane protein 14C RPB7_MOUSE DNA-directed RNA polymerase II subunit RPB7 ZFAN5_MOUSE AN1-type zinc finger protein 5 NUD17_MOUSE Nucleoside diphosphate-linked moiety X motif 17 CASP6_MOUSE Caspase-6 RSRC2_MOUSE Arginine/serine-rich coiled-coil protein 2 CMBL_MOUSE Carboxymethylenebutenolidase homolog AP2S1_MOUSE AP-2 complex subunit sigma GBB1_MOUSE Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 ATP8_MOUSE ATP synthase protein 8 RTN4_MOUSE Isoform 3 of Reticulon-4 ELP2_MOUSE Elongator complex protein 2 BNI3L_MOUSE BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like ARK72_MOUSE Aflatoxin B1 aldehyde reductase member 2 GILT_MOUSE Gamma-interferon-inducible lysosomal thiol reductase FNTB_MOUSE Protein farnesyltransferase subunit beta S35E3_MOUSE Solute carrier family 35 member E3 CRIP1_MOUSE Cysteine-rich protein 1 SPA3G_MOUSE Serine protease inhibitor A3G AK1CD_MOUSE Aldo-keto reductase family 1 member C13 TAGL_MOUSE Transgelin NCAM1_MOUSE Neural cell adhesion molecule 1 H2AX_MOUSE Histone H2AX AMPN_MOUSE Aminopeptidase N SAP18_MOUSE Histone deacetylase complex subunit SAP18 T176B_MOUSE Transmembrane protein 176B FDFT_MOUSE Squalene synthase SDF1_MOUSE Stromal cell-derived factor 1 PGH1_MOUSE Prostaglandin G/H synthase 1 DESM_MOUSE Desmin FADS2_MOUSE Fatty acid desaturase 2 GSTM7_MOUSE Glutathione S-transferase Mu 7 ERG1_MOUSE Squalene monooxygenase PROD_MOUSE Proline dehydrogenase 1, mitochondrial HBA_MOUSE Hemoglobin subunit alpha CAH13_MOUSE Carbonic anhydrase 13 MET15_MOUSE Probable methyltransferase-like protein 15 APOA1_MOUSE Apolipoprotein A-I APOO_MOUSE Apolipoprotein O S100G_MOUSE Protein S100-G DOCK5_MOUSE Dedicator of cytokinesis protein 5 SURF6_MOUSE Surfeit locus protein 6 RALA_MOUSE Ras-related protein Ral-A PTGIS_MOUSE Prostacyclin synthase JAM1_MOUSE Junctional adhesion molecule A SFXN2_MOUSE Sideroflexin-2 SC5A6_MOUSE Sodium-dependent multivitamin transporter
EP
Slc25a15 Rtfdc1 Nipsnap3b Gcc2 Ccdc22 Arhgef7 Fcgrt Mtnd1 Bpnt1 Calcoco1 S100b
AC C
sp|Q9WVD5|ORNT1_MOUSE sp|Q99K95|RTF2_MOUSE sp|Q9CQE1|NPS3B_MOUSE sp|Q8CHG3|GCC2_MOUSE sp|Q9JIG7|CCD22_MOUSE sp|Q9ES28|ARHG7_MOUSE sp|Q61559|FCGRN_MOUSE sp|P03888|NU1M_MOUSE sp|Q9Z0S1|BPNT1_MOUSE sp|Q8CGU1|CACO1_MOUSE sp|P50114|S100B_MOUSE sp|Q8BH50|CR025_MOUSE sp|Q9D115|ZN706_MOUSE sp|P23804|MDM2_MOUSE sp|Q80UU1|ANKZ1_MOUSE sp|Q9CQN6|TM14C_MOUSE sp|P62488|RPB7_MOUSE sp|O88878|ZFAN5_MOUSE sp|Q9CWD3|NUD17_MOUSE sp|O08738|CASP6_MOUSE sp|A2RTL5|RSRC2_MOUSE sp|Q8R1G2|CMBL_MOUSE sp|P62743|AP2S1_MOUSE sp|P62874|GBB1_MOUSE sp|P03930|ATP8_MOUSE sp|Q99P72-1|RTN4_MOUSE sp|Q91WG4|ELP2_MOUSE sp|Q9Z2F7|BNI3L_MOUSE sp|Q8CG76|ARK72_MOUSE sp|Q9ESY9|GILT_MOUSE sp|Q8K2I1|FNTB_MOUSE sp|Q6PGC7|S35E3_MOUSE sp|P63254|CRIP1_MOUSE sp|Q5I2A0|SPA3G_MOUSE sp|Q8VC28|AK1CD_MOUSE sp|P37804|TAGL_MOUSE sp|P13595|NCAM1_MOUSE sp|P27661|H2AX_MOUSE sp|P97449|AMPN_MOUSE sp|O55128|SAP18_MOUSE sp|Q9R1Q6|T176B_MOUSE sp|P53798|FDFT_MOUSE sp|P40224|SDF1_MOUSE sp|P22437|PGH1_MOUSE sp|P31001|DESM_MOUSE sp|Q9Z0R9|FADS2_MOUSE sp|Q80W21|GSTM7_MOUSE sp|P52019|ERG1_MOUSE sp|Q9WU79|PROD_MOUSE sp|P01942|HBA_MOUSE sp|Q9D6N1|CAH13_MOUSE sp|Q9DCL4|MET15_MOUSE sp|Q00623|APOA1_MOUSE sp|Q9DCZ4|APOO_MOUSE sp|P97816|S100G_MOUSE sp|B2RY04|DOCK5_MOUSE sp|P70279|SURF6_MOUSE sp|P63321|RALA_MOUSE sp|O35074|PTGIS_MOUSE sp|O88792|JAM1_MOUSE sp|Q925N2|SFXN2_MOUSE sp|Q5U4D8|SC5A6_MOUSE
191.385 125.573 126.288 154.241 108.475 104.024 131.327 139.29 284.977 131.045 130.476 145.039 93.8605 90.813 157.518 106.052 165.041 89.831 95.8979 114.633 99.0116 174.249 160.198 146.268 250.105 223.943 130.461 218.839 108.63 72.2107 219.504 192.802 128.6 191.496 173.587 130.452 105.943 83.9281 104.961 205.574 157.044 106.587 119.826 27.0812 34.478 158.501 91.2205 154.86 34.5698 123.821 118.563 137.274 100.931 97.7687 89.8571 81.5981 282.029 101.192 114.695 53.7171 104.062 174.354
165.373 189.338 142.919 190.801 122.132 162.04 143.336 86.8294 476.226 156.05 84.9687 62.7784 177.068 330.76 219.036 85.6156 164.614 28.9381 64.8074 185.856 115.359 159.967 139.313 417.536 115.879 104.547 105.055 152.508 124.966 37.417 200.492 326.642 69.099 197.616 80.387 87.1766 56.5573 122.765 72.4036 99.6836 78.6345 22.0961 59.2162 113.586 83.2383 48.4315 39.2007 57.7792 239.06 24.4348 104.444 140.595 75.2308 95.0268 33.1845 70.695 258.118 113.764 61.5347 55.2396 62.7413 186.529
126.874 325.34 108.979 287.693 189.797 200.015 150.181 79.1105 638.006 311.941 151.182 189.9 390.503 951.828 276.469 74.2449 168.4 106.055 126.691 136.451 194.522 353.574 136.232 530.383 180.753 238.689 88.5007 167.459 217.87 26.8235 188.895 508.292 107.331 362.742 96.9417 82.2449 29.9869 46.389 53.1126 131.345 97.0889 31.7808 73.0285 67.8788 168.59 67.706 56.4475 63.4875 366.35 16.355 169.447 107.351 128.698 53.2259 165.271 55.4139 231.066 67.5299 54.3968 26.8219 427.001 136.502
0.86 0.86 0.86 0.86 0.85 0.85 0.85 0.85 0.85 0.84 0.84 0.82 0.82 0.82 0.81 0.81 0.80 0.79 0.79 0.77 0.77 0.77 0.76 0.76 0.74 0.72 0.70 0.70 0.68 0.66 0.60 0.58 0.49 4.13 3.28 2.92 2.58 2.50 2.39 2.27 2.24 2.22 2.13 2.13 2.01 2.00 1.94 1.89 1.88 1.88 1.85 1.73 1.72 1.71 1.69 1.67 1.67 1.67 1.67 1.64 1.64 1.64
0.87 1.81 0.81 1.21 1.10 1.47 0.82 0.72 1.67 1.62 0.71 0.63 2.36 7.67 1.11 0.80 0.77 0.56 0.65 1.03 1.16 1.19 0.78 2.93 0.54 0.61 0.67 0.67 0.81 0.30 0.70 1.70 0.32 6.44 1.45 1.81 0.99 1.81 1.36 1.72 1.67 0.54 1.13 6.65 3.20 0.72 0.93 0.75 16.33 0.21 1.85 1.46 1.99 0.97 1.82 1.02 1.03 1.23 0.76 1.16 3.00 1.21
ACCEPTED MANUSCRIPT
TE D
121.68 49.3094 10.961 55.7648 91.2885 45.6625 175.282 48.4484 141.987 39.5705 58.6878 173.694 41.2357 57.03 58.0183 84.2438 83.4294 37.8897 65.4432 44.07 53.6905 52.4578 63.7224 158.993 82.2576 54.56 79.8284 143.672 79.3405 79.8107 37.3413 39.0387 39.6939 50.3419 78.1913 28.6757 111.809 77.1667 46.2351 100.38 32.3686 119.663 95.3409 63.9309 116.419 121.601 140.863 124.911 158.637 79.232 56.8613 131.908 44.6546 85.8093 97.9978 120.971 65.9903 93.0916 72.0716 67.7667 95.4787 96.3646
230.507 100.477 21.5423 94.7517 170.048 84.6007 269.726 87.0926 214.847 73.8362 106.829 307.572 68.132 117.819 115.433 157.969 143.659 60.9208 136.323 78.411 144.781 102.712 151.094 87.1508 160.22 89.5424 140.582 210.748 152.463 168.258 75.5975 53.0938 92.4534 108.75 105.017 55.959 140.794 119.286 72.9034 200.059 71.7395 198.452 183.334 106.108 181.675 173.945 247.304 216.962 300.079 134.758 95.5992 189.983 72.5191 159.007 142.851 138.54 102.368 172.564 115.091 118.043 160.514 144.481
RI PT
124.604 57.6613 11.2367 55.8848 81.1471 54.1108 109.971 52.206 139.842 37.5392 57.2642 185.785 44.0187 81.2863 76.2346 78.19 86.5882 41.7452 83.6895 48.5734 90.8778 66.8848 77.3522 94.087 97.6066 55.3176 82.634 137.089 91.4711 114.054 53.2245 21.0574 66.1632 76.5022 80.8847 36.9007 132.873 89.6091 55.4764 124.898 50.0086 129.346 116.72 56.408 106.818 119.888 161.178 140.545 206.011 91.3002 55.6507 108.763 52.2565 111.582 72.2614 112.506 69.2346 147.227 80.2338 76.486 107.475 94.2798
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
ABHD6_MOUSE Monoacylglycerol lipase ABHD6 MP2K3_MOUSE Dual specificity mitogen-activated protein kinase kinase 3 RAB21_MOUSE Ras-related protein Rab-21 CAN5_MOUSE Calpain-5 TIM14_MOUSE Mitochondrial import inner membrane translocase subunit TIM14 CMC2_MOUSE Calcium-binding mitochondrial carrier protein Aralar2 CC134_MOUSE Coiled-coil domain-containing protein 134 MFGM_MOUSE Lactadherin IRGM1_MOUSE Immunity-related GTPase family M protein 1 RU2B_MOUSE U2 small nuclear ribonucleoprotein B'' SHOC2_MOUSE Leucine-rich repeat protein SHOC-2 IF4G3_MOUSE Eukaryotic translation initiation factor 4 gamma 3 HTR5A_MOUSE HEAT repeat-containing protein 5A C1GLT_MOUSE Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 UB2J1_MOUSE Ubiquitin-conjugating enzyme E2 J1 F8VPP8_MOUSE Protein Zc3h7b ITPR3_MOUSE Inositol 1,4,5-trisphosphate receptor type 3 MPC1_MOUSE Mitochondrial pyruvate carrier 1 TI17B_MOUSE Mitochondrial import inner membrane translocase subunit Tim17-B STXB1_MOUSE Syntaxin-binding protein 1 COL12_MOUSE Collectin-12 ANR46_MOUSE Ankyrin repeat domain-containing protein 46 AHSA2_MOUSE Activator of 90 kDa heat shock protein ATPase homolog 2 ATIF1_MOUSE ATPase inhibitor, mitochondrial A2AT37_MOUSE Protein Upf2 TSC2_MOUSE Tuberin RAB31_MOUSE Ras-related protein Rab-31 RDH11_MOUSE Retinol dehydrogenase 11 TPSN_MOUSE Tapasin SFXN5_MOUSE Sideroflexin-5 SIK3_MOUSE Serine/threonine-protein kinase SIK3 TIM16_MOUSE Mitochondrial import inner membrane translocase subunit TIM16 RFC1_MOUSE Replication factor C subunit 1 RT33_MOUSE 28S ribosomal protein S33, mitochondrial F115A_MOUSE Protein FAM115A SUV3_MOUSE ATP-dependent RNA helicase SUPV3L1, mitochondrial FADS3_MOUSE Fatty acid desaturase 3 DJC16_MOUSE DnaJ homolog subfamily C member 16 EHBP1_MOUSE EH domain-binding protein 1 NDUB5_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial WDR46_MOUSE WD repeat-containing protein 46 FMNL2_MOUSE Formin-like protein 2 CADH2_MOUSE Cadherin-2 LYRM5_MOUSE LYR motif-containing protein 5 NDUAD_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NOC2L_MOUSE Nucleolar complex protein 2 homolog LYRM2_MOUSE LYR motif-containing protein 2 ARHGA_MOUSE Rho guanine nucleotide exchange factor 10 E9Q166_MOUSE Protein Atad2b SNTB2_MOUSE Beta-2-syntrophin GNA1_MOUSE Glucosamine 6-phosphate N-acetyltransferase TAM41_MOUSE Mitochondrial translocator assembly and maintenance protein 41 homolog NOP10_MOUSE H/ACA ribonucleoprotein complex subunit 3 SYTC2_MOUSE Probable threonine--tRNA ligase 2, cytoplasmic NDUF6_MOUSE NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 TV23B_MOUSE Golgi apparatus membrane protein TVP23 homolog B HEG1_MOUSE Protein HEG homolog 1 ADH7_MOUSE Alcohol dehydrogenase class 4 mu/sigma chain ARHGC_MOUSE Rho guanine nucleotide exchange factor 12 RCAS1_MOUSE Receptor-binding cancer antigen expressed on SiSo cells LCLT1_MOUSE Lysocardiolipin acyltransferase 1 SUN2_MOUSE SUN domain-containing protein 2
EP
Abhd6 Map2k3 Rab21 Capn5 Dnajc19 Slc25a13 Ccdc134 Mfge8 Irgm1 Snrpb2 Shoc2 Eif4g3 Heatr5a C1galt1 Ube2j1 Zc3h7b Itpr3 Mpc1 Timm17b Stxbp1 Colec12 Ankrd46 Ahsa2 Atpif1 Upf2 Tsc2 Rab31 Rdh11 Tapbp Sfxn5 Sik3 Pam16 Rfc1 Mrps33 Fam115a Supv3l1 Fads3 Dnajc16 Ehbp1 Ndufb5 Wdr46 Fmnl2 Cdh2 Lyrm5 Ndufa13 Noc2l Lyrm2 Arhgef10 Atad2b Sntb2 Gnpnat1 Tamm41 Nop10 Tarsl2 Ndufaf6 Tvp23b Heg1 Adh7 Arhgef12 Ebag9 Lclat1 Sun2
AC C
sp|Q8R2Y0|ABHD6_MOUSE sp|O09110|MP2K3_MOUSE sp|P35282|RAB21_MOUSE sp|O08688|CAN5_MOUSE sp|Q9CQV7|TIM14_MOUSE sp|Q9QXX4|CMC2_MOUSE sp|Q8C7V8|CC134_MOUSE sp|P21956|MFGM_MOUSE sp|Q60766|IRGM1_MOUSE sp|Q9CQI7|RU2B_MOUSE sp|O88520|SHOC2_MOUSE sp|Q80XI3|IF4G3_MOUSE sp|Q5PRF0|HTR5A_MOUSE sp|Q9JJ06|C1GLT_MOUSE sp|Q9JJZ4|UB2J1_MOUSE tr|F8VPP8|F8VPP8_MOUSE sp|P70227|ITPR3_MOUSE sp|P63030|MPC1_MOUSE sp|Q9Z0V7|TI17B_MOUSE sp|O08599|STXB1_MOUSE sp|Q8K4Q8|COL12_MOUSE sp|Q8BTZ5|ANR46_MOUSE sp|Q8N9S3|AHSA2_MOUSE sp|O35143|ATIF1_MOUSE tr|A2AT37|A2AT37_MOUSE sp|Q61037|TSC2_MOUSE sp|Q921E2|RAB31_MOUSE sp|Q9QYF1|RDH11_MOUSE sp|Q9R233|TPSN_MOUSE sp|Q925N0|SFXN5_MOUSE sp|Q6P4S6|SIK3_MOUSE sp|Q9CQV1|TIM16_MOUSE sp|P35601|RFC1_MOUSE sp|Q9D2R8|RT33_MOUSE sp|Q8BNE1|F115A_MOUSE sp|Q80YD1|SUV3_MOUSE sp|Q9JJE7|FADS3_MOUSE sp|Q80TN4|DJC16_MOUSE sp|Q69ZW3|EHBP1_MOUSE sp|Q9CQH3|NDUB5_MOUSE sp|Q9Z0H1|WDR46_MOUSE sp|A2APV2|FMNL2_MOUSE sp|P15116|CADH2_MOUSE sp|Q91V16|LYRM5_MOUSE sp|Q9ERS2|NDUAD_MOUSE sp|Q9WV70|NOC2L_MOUSE sp|Q8R033|LYRM2_MOUSE sp|Q8C033|ARHGA_MOUSE tr|E9Q166|E9Q166_MOUSE sp|Q61235|SNTB2_MOUSE sp|Q9JK38|GNA1_MOUSE sp|Q3TUH1|TAM41_MOUSE sp|Q9CQS2|NOP10_MOUSE sp|Q8BLY2|SYTC2_MOUSE sp|A2AIL4|NDUF6_MOUSE sp|Q9D8T4|TV23B_MOUSE sp|E9Q7X6|HEG1_MOUSE sp|Q64437|ADH7_MOUSE sp|Q8R4H2|ARHGC_MOUSE sp|Q9D0V7|RCAS1_MOUSE sp|Q3UN02|LCLT1_MOUSE sp|Q8BJS4|SUN2_MOUSE
169.202 71.589 14.0352 83.489 101.576 72.1457 177.534 70.7108 225.98 46.6688 73.716 249.081 63.8753 96.0633 91.2948 91.7057 117.637 59.7599 89.0394 61.4124 73.0449 76.7784 60.7569 291.122 107.599 73.0769 99.7585 203.508 99.1649 115.808 57.1035 34.9031 61.9412 76.1509 126.562 39.4261 214.19 121.774 74.0107 124.804 46.8699 157.478 119.196 65.2298 135.917 167.145 177.193 155.954 210.745 103.291 60.7501 143.887 60.3927 110.212 89.2754 179.013 81.4815 152.752 90.632 76.4276 112.317 111.355
147.205 203.716 587.425 97.1127 114.794 88.6514 207.27 68.9007 124.796 57.7667 150.927 235.867 81.9742 105.509 82.8942 45.8345 213.811 49.6597 114.948 108.785 36.8802 81.8764 75.1507 128.098 113.783 67.2868 177.497 181.505 63.9411 88.8183 60.7273 30.5816 42.6175 25.4304 129.781 51.3458 59.7134 109.681 60.0086 104.515 80.245 182.353 115.897 41.7356 132.088 182.075 98.625 102.425 75.3817 82.0681 95.792 134.766 47.319 125.885 91.779 166.253 117.298 119.154 100.633 72.0297 116.594 146.396
208.402 146.438 387.561 58.2826 107.124 40.4834 196.792 65.1945 87.2387 61.375 117.577 259.734 42.5653 72.28 130.127 167.732 134.227 18.8968 58.1247 52.2347 33.2739 102.29 79.9264 174.146 102.705 80.4452 130.93 128.303 65.7666 82.0994 62.3139 60.8524 68.2265 39.7708 93.0967 146.493 93.4668 91.6978 123.793 86.929 49.0799 102.426 103.67 74.5162 135.815 100.035 104.275 60.3786 75.2922 68.3856 89.6413 171.717 37.8653 103.583 93.605 88.5385 85.7551 64.4189 213.115 56.2693 87.4263 125.895
1.62 1.61 1.60 1.60 1.58 1.57 1.57 1.57 1.56 1.56 1.56 1.55 1.55 1.55 1.54 1.54 1.54 1.52 1.51 1.51 1.51 1.50 1.50 1.49 1.49 1.48 1.48 1.48 1.47 1.47 1.47 1.46 1.46 1.46 1.46 1.45 1.45 1.45 1.44 1.44 1.44 1.43 1.43 1.42 1.42 1.41 1.41 1.40 1.40 1.40 1.39 1.39 1.37 1.36 1.36 1.36 1.36 1.35 1.35 1.35 1.34 1.34
1.44 3.27 43.92 1.39 1.29 1.29 1.42 1.33 0.75 1.55 2.32 1.38 1.46 1.29 1.59 1.31 2.05 0.86 1.16 1.74 0.49 1.54 1.10 1.19 1.20 1.34 1.90 1.10 0.76 0.88 1.36 1.52 1.05 0.51 1.40 3.02 0.63 1.21 1.81 0.85 1.57 1.14 1.04 0.97 1.20 1.17 0.67 0.61 0.41 0.88 1.65 1.27 0.88 1.16 1.09 1.09 1.50 0.76 2.06 0.89 1.01 1.43
ACCEPTED MANUSCRIPT
59.3731 76.5677 162.106 49.6614 165.376 146.204 57.3368 126.67 64.7694 129.916 47.3269 111.749 316.599 164.759 85.1746 111.08 140.199 90.8927 97.9944 34.8447 62.6217 49.474 45.6137 50.7585 81.9116 90.4791 60.7991 62.4375 83.5623 95.7571 78.421 133.666 57.7171 58.853 72.4537 88.4601 154.976 115.152 131.124 70.0327 235.336 126.924 43.4262 180.521 178.016 53.5888 85.8475 64.1421 54.537 63.4732 65.3268 101.64 72.7402 69.248 36.1294 69.8427 84.7318 109.733 40.4733 106.353 96.673 75.1883
80.1222 91.1366 156.03 89.3166 238.993 213.465 106.278 193.616 79.5289 213.393 68.8336 167.355 229.248 243.549 134.753 198.394 197.876 116.344 156.717 67.2345 87.7088 67.7188 80.8004 65.1449 101.313 124.621 57.2556 90.9563 109.66 156.214 135.166 206.514 93.6274 94.7765 96.0564 126.591 233.194 152.143 175.131 91.7562 278.598 141.3 74.6608 256.922 227.391 77.9854 152.477 94.2562 84.3576 93.2548 47.9623 139.656 107.193 65.7533 60.3744 77.0363 117.144 166.284 59.7457 119.888 143.946 105.586
RI PT
64.9103 59.3943 150.812 64.6449 153.689 154.865 68.9912 121.79 45.8846 146.912 40.1805 129.019 121.339 168.406 88.723 142.7 136.743 86.2042 111.114 49.7377 77.1808 55.4913 61.7547 43.4908 78.3799 76.8518 44.9552 68.642 65.6777 122.452 103.677 136.739 61.464 77.666 68.5211 95.0197 162.176 116.984 159.391 70.4958 227.022 107.747 57.025 182.16 184.589 49.1171 114.184 78.1491 61.1894 63.1411 53.1312 104.026 73.9979 56.4446 48.3258 48.3582 90.5231 125.787 40.631 92.5691 112.161 80.7729
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
TE D
FMO2_MOUSE Dimethylaniline monooxygenase [N-oxide-forming] 2 FSTL1_MOUSE Follistatin-related protein 1 G3X9B1_MOUSE HEAT repeat containing 1 DI3L2_MOUSE DIS3-like exonuclease 2 CCD91_MOUSE Coiled-coil domain-containing protein 91 MSRB2_MOUSE Methionine-R-sulfoxide reductase B2, mitochondrial DCAF6_MOUSE DDB1- and CUL4-associated factor 6 CDK9_MOUSE Cyclin-dependent kinase 9 CBP_MOUSE CREB-binding protein SCFD2_MOUSE Sec1 family domain-containing protein 2 ANKL2_MOUSE Ankyrin repeat and LEM domain-containing protein 2 FBX7_MOUSE F-box only protein 7 S2551_MOUSE Solute carrier family 25 member 51 PLXA1_MOUSE Plexin-A1 SENP7_MOUSE Sentrin-specific protease 7 GALT_MOUSE Galactose-1-phosphate uridylyltransferase ANT3_MOUSE Antithrombin-III TF_MOUSE Tissue factor ENPP4_MOUSE Bis(5'-adenosyl)-triphosphatase enpp4 PB1_MOUSE Protein polybromo-1 UTP20_MOUSE Small subunit processome component 20 homolog PNO1_MOUSE RNA-binding protein PNO1 BCS1_MOUSE Mitochondrial chaperone BCS1 CD81_MOUSE CD81 antigen ILKAP_MOUSE Integrin-linked kinase-associated serine/threonine phosphatase 2C SMUG1_MOUSE Single-strand selective monofunctional uracil DNA glycosylase SYNRG_MOUSE Synergin gamma CL16A_MOUSE Protein CLEC16A SYEM_MOUSE Probable glutamate--tRNA ligase, mitochondrial TM261_MOUSE Transmembrane protein 261 FACR1_MOUSE Fatty acyl-CoA reductase 1 TDRP_MOUSE Testis development-related protein RAB13_MOUSE Ras-related protein Rab-13 METL8_MOUSE Methyltransferase-like protein 8 UACA_MOUSE Uveal autoantigen with coiled-coil domains and ankyrin repeats SEC62_MOUSE Translocation protein SEC62 CISD2_MOUSE CDGSH iron-sulfur domain-containing protein 2 PSB10_MOUSE Proteasome subunit beta type-10 NCLN_MOUSE Nicalin S27A4_MOUSE Long-chain fatty acid transport protein 4 YKT6_MOUSE Synaptobrevin homolog YKT6 CLCC1_MOUSE Chloride channel CLIC-like protein 1 MTMR2_MOUSE Myotubularin-related protein 2 ARL15_MOUSE ADP-ribosylation factor-like protein 15 PSME4_MOUSE Proteasome activator complex subunit 4 HBS1L_MOUSE HBS1-like protein ZDHC5_MOUSE Palmitoyltransferase ZDHHC5 PP4R1_MOUSE Serine/threonine-protein phosphatase 4 regulatory subunit 1 ABD12_MOUSE Monoacylglycerol lipase ABHD12 VATD_MOUSE V-type proton ATPase subunit D HDHD3_MOUSE Haloacid dehalogenase-like hydrolase domain-containing protein 3 D3Z7X0_MOUSE MCG142036 DJB12_MOUSE DnaJ homolog subfamily B member 12 CE290_MOUSE Centrosomal protein of 290 kDa RM18_MOUSE 39S ribosomal protein L18, mitochondrial TOM7_MOUSE Mitochondrial import receptor subunit TOM7 homolog ITPR2_MOUSE Inositol 1,4,5-trisphosphate receptor type 2 DTX3L_MOUSE E3 ubiquitin-protein ligase DTX3L ARMC8_MOUSE Armadillo repeat-containing protein 8 KAD1_MOUSE Adenylate kinase isoenzyme 1 N4BP1_MOUSE NEDD4-binding protein 1 CUTC_MOUSE Copper homeostasis protein cutC homolog
EP
Fmo2 Fstl1 Heatr1 Dis3l2 Ccdc91 Msrb2 Dcaf6 Cdk9 Crebbp Scfd2 Ankle2 Fbxo7 Slc25a51 Plxna1 Senp7 Galt Serpinc1 F3 Enpp4 Pbrm1 Utp20 Pno1 Bcs1l Cd81 Ilkap Smug1 Synrg Clec16a Ears2 Tmem261 Far1 Tdrp Rab13 Mettl8 Uaca Sec62 Cisd2 Psmb10 Ncln Slc27a4 Ykt6 Clcc1 Mtmr2 Arl15 Psme4 Hbs1l Zdhhc5 Ppp4r1 Abhd12 Atp6v1d Hdhd3 Acad12 Dnajb12 Cep290 Mrpl18 Tomm7 Itpr2 Dtx3l Armc8 Ak1 N4bp1 Cutc
AC C
sp|Q8K2I3|FMO2_MOUSE sp|Q62356|FSTL1_MOUSE tr|G3X9B1|G3X9B1_MOUSE sp|Q8CI75|DI3L2_MOUSE sp|Q9D8L5|CCD91_MOUSE sp|Q78J03|MSRB2_MOUSE sp|Q9DC22|DCAF6_MOUSE sp|Q99J95|CDK9_MOUSE sp|P45481|CBP_MOUSE sp|Q8BTY8|SCFD2_MOUSE sp|Q6P1H6|ANKL2_MOUSE sp|Q3U7U3|FBX7_MOUSE sp|Q5HZI9|S2551_MOUSE sp|P70206|PLXA1_MOUSE sp|Q8BUH8|SENP7_MOUSE sp|Q03249|GALT_MOUSE sp|P32261|ANT3_MOUSE sp|P20352|TF_MOUSE sp|Q8BTJ4|ENPP4_MOUSE sp|Q8BSQ9|PB1_MOUSE sp|Q5XG71|UTP20_MOUSE sp|Q9CPS7|PNO1_MOUSE sp|Q9CZP5|BCS1_MOUSE sp|P35762|CD81_MOUSE sp|Q8R0F6|ILKAP_MOUSE sp|Q6P5C5|SMUG1_MOUSE sp|Q5SV85|SYNRG_MOUSE sp|Q80U30|CL16A_MOUSE sp|Q9CXJ1|SYEM_MOUSE sp|Q9CQ00|TM261_MOUSE sp|Q922J9|FACR1_MOUSE sp|Q8C5P7|TDRP_MOUSE sp|Q9DD03|RAB13_MOUSE sp|A2AUU0|METL8_MOUSE sp|Q8CGB3|UACA_MOUSE sp|Q8BU14|SEC62_MOUSE sp|Q9CQB5|CISD2_MOUSE sp|O35955|PSB10_MOUSE sp|Q8VCM8|NCLN_MOUSE sp|Q91VE0|S27A4_MOUSE sp|Q9CQW1|YKT6_MOUSE sp|Q99LI2|CLCC1_MOUSE sp|Q9Z2D1|MTMR2_MOUSE sp|Q8BGR6|ARL15_MOUSE sp|Q5SSW2|PSME4_MOUSE sp|Q69ZS7|HBS1L_MOUSE sp|Q8VDZ4|ZDHC5_MOUSE sp|Q8K2V1|PP4R1_MOUSE sp|Q99LR1|ABD12_MOUSE sp|P57746|VATD_MOUSE sp|Q9CYW4|HDHD3_MOUSE tr|D3Z7X0|D3Z7X0_MOUSE sp|Q9QYI4|DJB12_MOUSE sp|Q6A078|CE290_MOUSE sp|Q9CQL5|RM18_MOUSE sp|Q9D173|TOM7_MOUSE sp|Q9Z329|ITPR2_MOUSE sp|Q3UIR3|DTX3L_MOUSE sp|Q9DBR3|ARMC8_MOUSE sp|Q9R0Y5|KAD1_MOUSE sp|Q6A037|N4BP1_MOUSE sp|Q9D8X1|CUTC_MOUSE
86.1449 90.5283 261.565 63.008 186.149 187.677 61.731 136.308 67.3492 153.747 47.0858 151.486 350.537 195.499 94.0974 135.537 166.477 116.162 116.196 43.1326 94.4062 68.9543 58.9875 57.3912 106.915 92.4761 79.9107 78.8383 83.6111 125.642 100.033 142.356 59.9756 81.1567 85.4154 109.305 174.068 145.807 197.643 88.523 313.832 158.959 53.7593 205.894 235.055 52.8652 102.225 86.8581 62.6733 67.3204 102.14 120.479 78.2174 92.8911 46.2075 71.9236 103.079 129.631 42.1316 129.549 117.784 89.5066
45.3837 43.1118 271.553 68.2433 132.878 31.2113 53.6604 121.494 150.141 166.978 52.7292 119.411 124.09 252.934 41.8466 104.082 239.029 70.7132 78.3033 128.801 106.399 56.1405 45.9431 55.4351 370.041 105.27 103.362 61.9018 34.6541 140.752 80.8684 49.7514 46.4177 35.1862 92.6864 177.366 157.558 53.0511 201.897 86.2362 241.158 37.3391 33.1884 168.249 213.266 52.9756 82.0759 92.3019 45.8742 86.4997 43.759 55.4151 84.4128 473.879 25.9031 154.529 194.731 125.295 38.9342 113.885 84.6444 82.7653
99.1153 89.4081 141.932 113.873 350.604 158.233 90.739 112.895 391.282 113.655 112.77 84.7202 187.866 179.931 90.0637 159.194 246.112 59.5147 90.1485 99.0829 66.9725 44.8303 24.8766 34.5822 533.311 152.98 89.5965 36.4073 74.162 88.0827 191.135 195.504 28.9786 64.9823 103.297 164.136 137.97 121.802 118.715 56.2148 161.436 18.9916 32.8371 225.573 181.16 50.348 82.8072 139.801 47.213 70.516 74.1526 69.1664 77.6585 291.096 34.43 80.4865 177.015 189.968 30.1214 169.02 132.288 120.18
1.34 1.34 1.33 1.33 1.33 1.33 1.33 1.33 1.33 1.33 1.32 1.32 1.32 1.32 1.32 1.32 1.32 1.31 1.31 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.29 1.29 1.29 1.29 1.29 1.29 1.29 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.27 1.27 1.27 1.27 1.27 1.27 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.25 1.25 1.25
1.16 0.97 1.32 1.59 1.52 0.63 1.14 0.94 4.89 1.01 1.89 0.85 0.71 1.30 0.76 1.04 1.75 0.74 0.81 2.69 1.24 0.96 0.66 0.96 5.64 1.54 1.82 0.75 0.73 1.05 1.49 0.91 0.63 0.73 1.39 1.86 0.93 0.75 1.10 1.01 0.87 0.24 0.66 1.09 1.09 1.01 0.82 1.63 0.80 1.24 1.00 0.61 1.10 6.09 0.71 1.99 2.12 1.34 0.85 1.42 1.04 1.30
ACCEPTED MANUSCRIPT
TE D
83.4032 42.0716 63.7494 128.465 72.0462 60.5767 75.3963 126.567 77.5802 129.136 79.4935 98.1082 63.4026 60.9256 74.5944 134.027 85.3341 95.2333 139.274 96.0023 57.2844 73.95 104.486 67.5962 133.83 81.5952 57.0243 93.7554 85.833 31.6073 157.023 86.9024 91.3594 96.573 159.961 95.5324 33.1631 164.813 64.0109 83.6375 77.5576 96.9583 72.8676 45.92 72.3358 77.3723 153.708 85.0247 44.1677 48.3311 91.6991 262.598 92.9035 118.188 108.11 60.359 40.1937 66.7157 61.9579 93.3023 79.1595 55.9961
121.969 63.7935 79.7405 202.841 112.321 71.7291 105.101 164.604 86.3572 207.45 124.029 156.534 85.4736 76.9006 88.6463 118.984 115.79 142.908 188.073 128.686 89.4639 61.4905 153.206 83.0421 154.998 108.199 100.154 131.475 132.536 49.2367 231.817 122.167 129.7 145.293 141.938 125.175 39.9613 234.348 59.9642 95.5855 94.2251 140.263 96.0296 54.3824 112.703 101.687 206.517 111.989 59.8007 73.0248 143.9 360.804 142.988 138.858 156.42 90.9412 62.9737 76.786 93.3463 130.058 113.477 59.6881
RI PT
88.1002 53.48 56.3378 133.083 79.4553 65.915 75.2587 126.932 58.375 151.913 92.5686 112.108 67.0712 61.1345 58.0436 114.115 88.0387 110.231 145.595 94.4875 68.3587 51.5864 128.243 59.6852 112.768 78.4769 77.1345 108.906 106.274 38.7568 168.422 113.843 99.6467 119.973 167.302 101.226 29.4528 183.553 51.2768 93.8342 84.348 89.9818 78.0973 41.7638 94.4825 87.9599 165.592 74.9375 53.4692 60.5567 116.995 260.185 118.868 136.954 134.386 75.1484 54.0069 60.6669 73.7315 108.621 96.9727 58.2427
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
XXLT1_MOUSE Xyloside xylosyltransferase 1 DIEXF_MOUSE Digestive organ expansion factor homolog CCNT1_MOUSE Cyclin-T1 MSS4_MOUSE Guanine nucleotide exchange factor MSS4 SARAF_MOUSE Store-operated calcium entry-associated regulatory factor DPEP1_MOUSE Dipeptidase 1 PGFS_MOUSE Prostamide/prostaglandin F synthase SIR5_MOUSE NAD-dependent protein deacylase sirtuin-5, mitochondrial PG12A_MOUSE Group XIIA secretory phospholipase A2 GCP2_MOUSE Gamma-tubulin complex component 2 CERU_MOUSE Ceruloplasmin DDX27_MOUSE Probable ATP-dependent RNA helicase DDX27 ADA10_MOUSE Disintegrin and metalloproteinase domain-containing protein 10 TRM2A_MOUSE tRNA (uracil-5-)-methyltransferase homolog A NOSIP_MOUSE Nitric oxide synthase-interacting protein RCL1_MOUSE RNA 3'-terminal phosphate cyclase-like protein UH1BL_MOUSE UHRF1-binding protein 1-like T126A_MOUSE Transmembrane protein 126A 2A5A_MOUSE Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform PRIO_MOUSE Major prion protein TAF6_MOUSE Transcription initiation factor TFIID subunit 6 COX19_MOUSE Cytochrome c oxidase assembly protein COX19 SPTB1_MOUSE Spectrin beta chain, erythrocytic VKGC_MOUSE Vitamin K-dependent gamma-carboxylase ZY11B_MOUSE Protein zyg-11 homolog B RM54_MOUSE 39S ribosomal protein L54, mitochondrial TRM1L_MOUSE TRMT1-like protein NUP85_MOUSE Nuclear pore complex protein Nup85 RFC2_MOUSE Replication factor C subunit 2 PGPI_MOUSE Pyroglutamyl-peptidase 1 GLCNE_MOUSE Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase RMD2_MOUSE Regulator of microtubule dynamics protein 2 PACS1_MOUSE Phosphofurin acidic cluster sorting protein 1 ACOT8_MOUSE Acyl-coenzyme A thioesterase 8 GALE_MOUSE UDP-glucose 4-epimerase RNF13_MOUSE E3 ubiquitin-protein ligase RNF13 KTI12_MOUSE Protein KTI12 homolog QRIC1_MOUSE Glutamine-rich protein 1 PSD10_MOUSE 26S proteasome non-ATPase regulatory subunit 10 LPP3_MOUSE Lipid phosphate phosphohydrolase 3 MOT1_MOUSE Monocarboxylate transporter 1 MED15_MOUSE Mediator of RNA polymerase II transcription subunit 15 TIF1A_MOUSE Transcription intermediary factor 1-alpha EXOS3_MOUSE Exosome complex component RRP40 C2D1B_MOUSE Coiled-coil and C2 domain-containing protein 1B PPARG_MOUSE Peroxisome proliferator-activated receptor gamma DEOC_MOUSE Putative deoxyribose-phosphate aldolase NECP1_MOUSE Adaptin ear-binding coat-associated protein 1 CCZ1_MOUSE Vacuolar fusion protein CCZ1 homolog RAB35_MOUSE Ras-related protein Rab-35 TOR2A_MOUSE Torsin-2A DOPD_MOUSE D-dopachrome decarboxylase RM48_MOUSE 39S ribosomal protein L48, mitochondrial COX14_MOUSE Cytochrome c oxidase assembly protein COX14 TRMB_MOUSE tRNA (guanine-N(7)-)-methyltransferase SELO_MOUSE Selenoprotein O WDR18_MOUSE WD repeat-containing protein 18 MOC2A_MOUSE Molybdopterin synthase sulfur carrier subunit SPG20_MOUSE Spartin PAFA2_MOUSE Platelet-activating factor acetylhydrolase 2, cytoplasmic KS6A1_MOUSE Ribosomal protein S6 kinase alpha-1 MSPD2_MOUSE Motile sperm domain-containing protein 2
EP
Xxylt1 Diexf Ccnt1 Rabif Tmem66 Dpep1 Fam213b Sirt5 Pla2g12a Tubgcp2 Cp Ddx27 Adam10 Trmt2a Nosip Rcl1 Uhrf1bp1l Tmem126a Ppp2r5a Prnp Taf6 Cox19 Sptb Ggcx Zyg11b Mrpl54 Trmt1l Nup85 Rfc2 Pgpep1 Gne Rmdn2 Pacs1 Acot8 Gale Rnf13 Kti12 Qrich1 Psmd10 Ppap2b Slc16a1 Med15 Trim24 Exosc3 Cc2d1b Pparg Dera Necap1 Ccz1 Rab35 Tor2a Ddt Mrpl48 Cox14 Mettl1 Selo Wdr18 Mocs2 Spg20 Pafah2 Rps6ka1 Mospd2
AC C
sp|Q3U4G3|XXLT1_MOUSE sp|Q8BTT6|DIEXF_MOUSE sp|Q9QWV9|CCNT1_MOUSE sp|Q91X96|MSS4_MOUSE sp|Q8R3Q0|SARAF_MOUSE sp|P31428|DPEP1_MOUSE sp|Q9DB60|PGFS_MOUSE sp|Q8K2C6|SIR5_MOUSE sp|Q9EPR2|PG12A_MOUSE sp|Q921G8|GCP2_MOUSE sp|Q61147|CERU_MOUSE sp|Q921N6|DDX27_MOUSE sp|O35598|ADA10_MOUSE sp|Q8BNV1|TRM2A_MOUSE sp|Q9D6T0|NOSIP_MOUSE sp|Q9JJT0|RCL1_MOUSE sp|A2RSJ4|UH1BL_MOUSE sp|Q9D8Y1|T126A_MOUSE sp|Q6PD03|2A5A_MOUSE sp|P04925|PRIO_MOUSE sp|Q62311|TAF6_MOUSE sp|Q8K0C8|COX19_MOUSE sp|P15508|SPTB1_MOUSE sp|Q9QYC7|VKGC_MOUSE sp|Q3UFS0|ZY11B_MOUSE sp|Q9CPW3|RM54_MOUSE sp|A2RSY6|TRM1L_MOUSE sp|Q8R480|NUP85_MOUSE sp|Q9WUK4|RFC2_MOUSE sp|Q9ESW8|PGPI_MOUSE sp|Q91WG8|GLCNE_MOUSE sp|Q8BSE0|RMD2_MOUSE sp|Q8K212|PACS1_MOUSE sp|P58137|ACOT8_MOUSE sp|Q8R059|GALE_MOUSE sp|O54965|RNF13_MOUSE sp|Q9D1R2|KTI12_MOUSE sp|Q3UA37|QRIC1_MOUSE sp|Q9Z2X2|PSD10_MOUSE sp|Q99JY8|LPP3_MOUSE sp|P53986|MOT1_MOUSE sp|Q924H2|MED15_MOUSE sp|Q64127|TIF1A_MOUSE sp|Q7TQK4|EXOS3_MOUSE sp|Q8BRN9|C2D1B_MOUSE sp|P37238|PPARG_MOUSE sp|Q91YP3|DEOC_MOUSE sp|Q9CR95|NECP1_MOUSE sp|Q8C1Y8|CCZ1_MOUSE sp|Q6PHN9|RAB35_MOUSE sp|Q8R1J9|TOR2A_MOUSE sp|O35215|DOPD_MOUSE sp|Q8JZS9|RM48_MOUSE sp|Q8BH51|COX14_MOUSE sp|Q9Z120|TRMB_MOUSE sp|Q9DBC0|SELO_MOUSE sp|Q4VBE8|WDR18_MOUSE sp|Q9Z224|MOC2A_MOUSE sp|Q8R1X6|SPG20_MOUSE sp|Q8VDG7|PAFA2_MOUSE sp|P18653|KS6A1_MOUSE sp|Q9CWP6|MSPD2_MOUSE
92.2703 55.5314 70.0465 123.067 76.3978 85.8288 82.3973 150.096 82.3142 141.129 89.0283 103.727 76.0587 74.1721 75.2848 187.542 98.0569 110.476 162.688 105.573 64.9763 92.7996 132.686 73.292 147.399 87.846 64.1172 116.235 102.209 36.5326 164.369 122.019 102.488 117.765 254.814 113.068 35.8441 187.337 79.5313 118.741 100.591 84.5127 85.4344 51.0102 87.6436 96.8135 176.695 79.9181 57.2561 57.3296 105.883 262.13 109.04 164.57 131.918 69.945 48.8628 74.0871 67.3439 108.921 94.5373 75.0724
58.7507 58.8253 95.7753 112.145 72.7384 24.263 133.989 95.19 75.9006 161.176 50.3514 156.784 77.2185 116.741 104.709 203.57 85.0291 144.889 125.895 113.204 61.1687 59.9173 131.175 113.217 186.833 23.9512 402.563 123.79 92.0153 59.8017 137.073 88.5615 121.091 175.436 135.28 76.7431 71.5607 164.002 72.6028 74.4669 148.094 96.8824 109.272 66.6284 65.9148 81.0973 198.796 83.4214 80.3057 97.3946 59.8449 223.343 43.6867 157.898 109.935 82.5632 51.5462 62.0745 94.0025 116.081 108.009 43.5783
82.1513 28.4215 158.203 178.417 77.4334 29.3183 250.953 249.789 151.064 138.878 80.4308 44.7378 111.28 116.546 234.699 107.108 132.968 100.266 94.9021 161.78 56.624 122.541 96.0901 100.503 107.589 105.066 378.389 80.5853 65.7119 52.4038 142.97 84.8002 98.9258 132.245 109.017 83.8131 221.339 142.787 149.099 62.7048 61.3969 239.088 224.642 36.4956 78.677 156.787 126.436 114.235 74.8014 111.957 72.3328 681.821 58.8238 193.007 76.9786 109.75 40.3809 211.756 133.279 88.0005 111.854 58.4684
1.25 1.25 1.25 1.25 1.25 1.25 1.24 1.24 1.24 1.24 1.24 1.24 1.24 1.24 1.24 1.24 1.23 1.23 1.23 1.23 1.23 1.23 1.23 1.23 1.23 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.21 1.21 1.21 1.21 1.21 1.21 1.21 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.19 1.19 1.19 1.19 1.19 1.19 1.18 1.18 1.18 1.18 1.18
0.82 0.91 2.11 1.11 0.99 0.42 2.56 1.36 1.67 1.07 0.76 0.96 1.44 1.91 2.56 1.25 1.26 1.19 0.78 1.44 0.94 1.45 0.98 1.68 1.19 0.81 5.82 1.01 0.82 1.59 0.86 0.86 1.15 1.42 0.75 0.82 4.68 0.88 1.92 0.77 1.29 1.80 2.21 1.18 0.87 1.44 1.02 1.24 1.59 1.92 0.63 1.73 0.48 1.38 0.77 1.42 0.98 2.15 1.68 1.01 1.25 0.89
ACCEPTED MANUSCRIPT
63.063 72.153 67.1992 48.0084 181.268 75.7476 132.137 90.3187 104.752 151.416 178.252 91.9372 84.1385 146.054 99.9363 120.659 187.296 135.312 78.3857 97.0108 118.959 82.1208 118.512 76.9075 57.7096 103.196 100.067 73.1116 112.627 86.5056 41.0508 28.3232 79.2079 99.7871 83.5767 138.7 50.9348 100.37 86.4502 190.788 64.7205 41.653 44.6177 65.944 98.7759 47.9001 100.699 110.609 119.242 53.2734 77.4297 89.4217 89.7929 126.841 77.7968 50.2356 65.0808 105.775 107.603 168.739 77.0059 79.2379
93.4812 98.7719 93.4915 68.4067 219.443 102.889 151.572 143.867 131.849 196.215 244.4 103.62 114.237 217.272 138.965 165.024 259.01 205.635 151.569 139.4 157.133 106.71 141.101 111.962 84.6038 147.554 147.269 99.8295 139.791 102.802 41.852 40.9937 123.437 162.588 102.138 205.706 65.4481 136.088 125.005 225.939 72.2041 56.4954 64.0657 93.0502 100.308 61.8205 127.239 137.086 169.749 64.8886 107.005 107.352 106.253 144.545 92.8558 48.8532 79.9049 118.947 130.075 177.468 89.7119 98.8834
RI PT
80.7903 76.9452 84.5476 55.6009 178.398 92.9226 80.2394 108.538 106.059 150.557 172.021 92.3141 99.2512 144.834 108.799 130.323 179.188 174.267 121.382 116 121.215 83.3782 160.836 91.7995 74.6996 122.046 136.281 75.5867 118.046 82.9011 38.325 31.3214 101.109 133.66 87.2233 169.967 51.5613 125.836 111.477 182.911 50.816 52.8978 58.3901 70.7834 81.0754 57.0818 107.552 108.089 130.972 54.2751 87.8868 92.3914 79.61 116.655 79.9014 39.2747 67.3915 109.748 128.814 162.287 68.5424 99.0946
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
TE D
Gm15800 Iffo1 Asap2 Smek1 Lancl2 Ube4b Adrbk1 Pde3b Rbm19 Tmem214 Alg1 Sars2 Ifrd1 Arpin Ist1 Bloc1s2 Ngly1 Paxbp1 Aox1 Prdx4 Sidt2 Micu3 Snrpb Arl6 Nmt2 Ptpra Copz1 Yap1 Ppan Adal Letmd1 Hax1 Mroh1 Mogs Rap2c Dnajc21 Kifap3 Stag1 Trabd Slc2a1 Toe1
RT14_MOUSE 28S ribosomal protein S14, mitochondrial RT21_MOUSE 28S ribosomal protein S21, mitochondrial Q6PD28_MOUSE Protein Ppp2r5b ALG11_MOUSE GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase ABH15_MOUSE Abhydrolase domain-containing protein 15 CNNM3_MOUSE Metal transporter CNNM3 PYRD2_MOUSE Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 THNS1_MOUSE Threonine synthase-like 1 AF1L2_MOUSE Actin filament-associated protein 1-like 2 NOL7_MOUSE Nucleolar protein 7 NUCG_MOUSE Endonuclease G, mitochondrial P3H3_MOUSE Prolyl 3-hydroxylase 3 F91A1_MOUSE Protein FAM91A1 TRIO_MOUSE Triple functional domain protein VPS41_MOUSE Vacuolar protein sorting-associated protein 41 homolog DNJC5_MOUSE DnaJ homolog subfamily C member 5 GMPPA_MOUSE Mannose-1-phosphate guanyltransferase alpha FXRD1_MOUSE FAD-dependent oxidoreductase domain-containing protein 1 IF2M_MOUSE Translation initiation factor IF-2, mitochondrial KPRA_MOUSE Phosphoribosyl pyrophosphate synthase-associated protein 1 CD027_MOUSE UPF0609 protein C4orf27 homolog E9PX61_MOUSE Protein Gm15800 IFFO1_MOUSE Intermediate filament family orphan 1 ASAP2_MOUSE Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 P4R3A_MOUSE Serine/threonine-protein phosphatase 4 regulatory subunit 3A LANC2_MOUSE LanC-like protein 2 UBE4B_MOUSE Ubiquitin conjugation factor E4 B ARBK1_MOUSE Beta-adrenergic receptor kinase 1 PDE3B_MOUSE cGMP-inhibited 3',5'-cyclic phosphodiesterase B RBM19_MOUSE Probable RNA-binding protein 19 TM214_MOUSE Transmembrane protein 214 ALG1_MOUSE Chitobiosyldiphosphodolichol beta-mannosyltransferase SYSM_MOUSE Serine--tRNA ligase, mitochondrial IFRD1_MOUSE Interferon-related developmental regulator 1 ARPIN_MOUSE Arpin IST1_MOUSE IST1 homolog BL1S2_MOUSE Biogenesis of lysosome-related organelles complex 1 subunit 2 NGLY1_MOUSE Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase PAXB1_MOUSE PAX3- and PAX7-binding protein 1 AOXA_MOUSE Aldehyde oxidase 1 PRDX4_MOUSE Peroxiredoxin-4 SIDT2_MOUSE SID1 transmembrane family member 2 MICU3_MOUSE Calcium uptake protein 3, mitochondrial RSMB_MOUSE Small nuclear ribonucleoprotein-associated protein B ARL6_MOUSE ADP-ribosylation factor-like protein 6 NMT2_MOUSE Glycylpeptide N-tetradecanoyltransferase 2 PTPRA_MOUSE Receptor-type tyrosine-protein phosphatase alpha COPZ1_MOUSE Coatomer subunit zeta-1 YAP1_MOUSE Yorkie homolog SSF1_MOUSE Suppressor of SWI4 1 homolog ADAL_MOUSE Adenosine deaminase-like protein LTMD1_MOUSE LETM1 domain-containing protein 1 HAX1_MOUSE HCLS1-associated protein X-1 E0CZ22_MOUSE Protein Mroh1 MOGS_MOUSE Mannosyl-oligosaccharide glucosidase RAP2C_MOUSE Ras-related protein Rap-2c E9Q8D0_MOUSE Protein Dnajc21 KIFA3_MOUSE Kinesin-associated protein 3 STAG1_MOUSE Cohesin subunit SA-1 TRABD_MOUSE TraB domain-containing protein GTR1_MOUSE Solute carrier family 2, facilitated glucose transporter member 1 TOE1_MOUSE Target of EGR1 protein 1
EP
Mrps14 Mrps21 Ppp2r5b Alg11 Abhd15 Cnnm3 Pyroxd2 Thnsl1 Afap1l2 Nol7 Endog Leprel2 Fam91a1 Trio Vps41 Dnajc5 Gmppa Foxred1 Mtif2 Prpsap1
AC C
sp|Q9CR88|RT14_MOUSE sp|P58059|RT21_MOUSE tr|Q6PD28|Q6PD28_MOUSE sp|Q3TZM9|ALG11_MOUSE sp|Q5F2F2|ABH15_MOUSE sp|Q32NY4|CNNM3_MOUSE sp|Q3U4I7|PYRD2_MOUSE sp|Q8BH55|THNS1_MOUSE sp|Q5DTU0|AF1L2_MOUSE sp|Q9D7Z3|NOL7_MOUSE sp|O08600|NUCG_MOUSE sp|Q8CG70|P3H3_MOUSE sp|Q3UVG3|F91A1_MOUSE sp|Q0KL02|TRIO_MOUSE sp|Q5KU39|VPS41_MOUSE sp|P60904|DNJC5_MOUSE sp|Q922H4|GMPPA_MOUSE sp|Q3TQB2|FXRD1_MOUSE sp|Q91YJ5|IF2M_MOUSE sp|Q9D0M1|KPRA_MOUSE sp|Q8CFE2|CD027_MOUSE tr|E9PX61|E9PX61_MOUSE sp|Q8BXL9|IFFO1_MOUSE sp|Q7SIG6|ASAP2_MOUSE sp|Q6P2K6|P4R3A_MOUSE sp|Q9JJK2|LANC2_MOUSE sp|Q9ES00|UBE4B_MOUSE sp|Q99MK8|ARBK1_MOUSE sp|Q61409|PDE3B_MOUSE sp|Q8R3C6|RBM19_MOUSE sp|Q8BM55|TM214_MOUSE sp|Q921Q3|ALG1_MOUSE sp|Q9JJL8|SYSM_MOUSE sp|P19182|IFRD1_MOUSE sp|Q9D0A3|ARPIN_MOUSE sp|Q9CX00|IST1_MOUSE sp|Q9CWG9|BL1S2_MOUSE sp|Q9JI78|NGLY1_MOUSE sp|P58501|PAXB1_MOUSE sp|O54754|AOXA_MOUSE sp|O08807|PRDX4_MOUSE sp|Q8CIF6|SIDT2_MOUSE sp|Q9CTY5|MICU3_MOUSE sp|P27048|RSMB_MOUSE sp|O88848|ARL6_MOUSE sp|O70311|NMT2_MOUSE sp|P18052|PTPRA_MOUSE sp|P61924|COPZ1_MOUSE sp|P46938|YAP1_MOUSE sp|Q91YU8|SSF1_MOUSE sp|Q80SY6|ADAL_MOUSE sp|Q924L1|LTMD1_MOUSE sp|O35387|HAX1_MOUSE tr|E0CZ22|E0CZ22_MOUSE sp|Q80UM7|MOGS_MOUSE sp|Q8BU31|RAP2C_MOUSE tr|E9Q8D0|E9Q8D0_MOUSE sp|P70188|KIFA3_MOUSE sp|Q9D3E6|STAG1_MOUSE sp|Q99JY4|TRABD_MOUSE sp|P17809|GTR1_MOUSE sp|Q9D2E2|TOE1_MOUSE
76.0844 76.7652 85.094 53.4835 203.544 95.2192 97.8167 89.6032 115.507 157.852 166.18 112.196 100.492 122.926 105.116 128.168 168.691 155.559 81.5037 109.114 122.983 86.2422 184.434 83.931 69.0306 113.763 126.79 72.4988 127.428 93.2221 49.9891 27.9782 84.2229 106.181 94.3288 148.571 52.0582 122.968 101.44 201.346 59.8316 51.0916 53.0936 61.7606 103.101 56.7895 108.016 109.943 112.309 55.9469 78.7257 96.8424 83.9736 128.78 84.0062 51.2739 68.2066 121.849 133.974 191.697 72.5197 99.8809
56.5918 22.0952 43.3398 57.32 99.753 244.475 73.9618 63.6545 41.4943 97.0479 188.888 48.3325 154.799 190.748 137.133 153.119 215.865 56.4059 72.149 137.692 116.267 121.46 86.39 170.542 54.15 115.565 141.957 79.5384 84.1699 57.8517 52.9939 35.684 77.4415 270.389 66.8715 171.846 38.7548 81.7936 155.48 148.855 140.231 50.0665 60.5815 65.8452 117.189 158.397 109.705 117.041 120.902 280.475 67.7068 54.8172 51.4833 134.129 62.958 55.8592 55.8274 104.424 148.213 293.921 251.855 81.0866
91.6392 70.6424 36.2168 52.8452 128.725 209.191 116.142 101.233 130.876 103.557 262.414 41.8756 107.141 418.838 138.903 103.244 122.939 113.435 104.963 112.662 132.82 139.586 376.6 146.485 69.9463 73.0312 166.992 102.303 110.456 106.355 50.915 67.0432 133.498 88.3328 123.419 172.034 59.3628 122.55 171.158 224.323 154.307 51.3022 52.586 59.9331 112.351 90.3983 68.6355 97.1946 220.305 242.992 88.5248 50.5283 186.767 152.5 53.8521 45.5673 99.2175 85.9749 130.815 220.62 61.6103 61.307
1.18 1.18 1.18 1.18 1.18 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.15 1.15 1.15 1.15 1.15 1.15 1.14 1.14 1.14 1.14 1.14 1.13 1.13 1.13 1.13 1.13 1.13 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.11 1.11
1.03 0.62 0.52 1.06 0.64 2.69 0.90 0.83 0.82 0.66 1.29 0.49 1.43 2.10 1.32 1.02 0.92 0.55 0.89 1.18 1.04 1.58 1.66 1.88 0.94 0.84 1.31 1.22 0.84 0.97 1.31 1.72 1.17 1.54 1.11 1.11 0.96 0.90 1.65 1.00 2.55 1.07 1.10 0.92 1.28 2.37 0.86 0.98 1.36 4.87 0.95 0.58 1.41 1.18 0.74 1.13 1.17 0.88 1.18 1.55 2.15 0.80
ACCEPTED MANUSCRIPT
M AN U
TE D
138.497 45.5682 157.608 72.6146 49.581 182.086 97.2937 117.574 130.636 55.5419 82.7091 36.0743 126.28 80.7849 118.542 132.16 54.4752 87.4987 112.481 116.584 52.6492 66.3229 118.608 68.3183 110.553 57.8821 90.3142 40.7868 87.8215 94.2598 234.502 128.446 68.7387 57.6366 71.4833 108.759 129.543 92.0205 65.2595 125.428 54.8321 43.5723 56.1345 86.4517 67.23 38.0246 78.072 119.32 54.5597 50.8881 53.3526 80.7156 84.4068 63.9854 115.926 125.273 313.489 48.8915 67.8059 144.255 122.041 68.9217
150.236 65.9122 187.217 55.3949 75.4377 159.811 113.78 132.313 157.562 79.0291 97.0006 50.1698 171.417 105.161 129.954 140.613 59.4081 109.995 141.464 133.805 61.7544 81.4726 130.082 93.5471 125.696 76.5103 138.361 56.4605 143.298 110.22 268.029 130.323 77.0031 58.7822 83.6863 108.217 167.294 103.878 80.4743 137.325 59.1142 55.927 67.5363 109.353 83.8502 52.9773 105.599 114.846 54.6879 59.7284 71.1052 109.106 116.808 69.8259 123.338 172.759 334.874 58.0224 62.419 105.534 155.162 91.1598
RI PT
124.217 50.6333 160.26 42.1904 71.6181 113.638 92.9981 104.089 136.694 76.4845 86.7043 40.1862 135.813 97.376 102.214 117.289 59.2555 99.8232 133.293 101.371 55.7474 65.2425 126.459 76.178 102.61 56.5552 119.024 45.0153 129.128 91.8307 209.243 111.707 74.7812 67.1744 79.5603 98.3385 165.504 89.7322 78.4734 105.678 49.7384 44.1488 62.8432 90.3611 67.2083 39.8425 109.275 113.988 57.5975 52.626 58.7188 92.9736 91.8653 72.2858 114.979 138.992 322.682 57.0951 51.7972 132.652 139.316 75.8806
SC
T22D1_MOUSE TSC22 domain family protein 1 2 ASPC1_MOUSE Tether containing UBX domain for GLUT4 2 KPCD_MOUSE Protein kinase C delta type 2 SDF2_MOUSE Stromal cell-derived factor 2 2 Q0VBL3_MOUSE Protein Rbm15 2 MPP10_MOUSE U3 small nucleolar ribonucleoprotein protein MPP10 2 RPE_MOUSE Ribulose-phosphate 3-epimerase 2 ZEB2_MOUSE Zinc finger E-box-binding homeobox 2 2 AP4E1_MOUSE AP-4 complex subunit epsilon-1 2 CRBN_MOUSE Protein cereblon 2 TNR6B_MOUSE Trinucleotide repeat-containing gene 6B protein 2 RPB9_MOUSE DNA-directed RNA polymerase II subunit RPB9 2 LMF1_MOUSE Lipase maturation factor 1 2 F175B_MOUSE BRISC complex subunit Abro1 2 POMP_MOUSE Proteasome maturation protein 2 CIC_MOUSE Protein capicua homolog 2 GCP3_MOUSE Gamma-tubulin complex component 3 2 YIPF4_MOUSE Protein YIPF4 2 D3YYU8_MOUSE Protein Obsl1 2 STAR5_MOUSE StAR-related lipid transfer protein 5 2 TAF10_MOUSE Transcription initiation factor TFIID subunit 10 2 PPIE_MOUSE Peptidyl-prolyl cis-trans isomerase E 2 EMAL4_MOUSE Echinoderm microtubule-associated protein-like 4 2 GDPD1_MOUSE Glycerophosphodiester phosphodiesterase domain-containing protein 1 2 TMA16_MOUSE Translation machinery-associated protein 16 2 BL1S1_MOUSE Biogenesis of lysosome-related organelles complex 1 subunit 1 2 MK03_MOUSE Mitogen-activated protein kinase 3 2 FNBP4_MOUSE Formin-binding protein 4 2 A2AFK4_MOUSE GTP binding protein 5, isoform CRA_a 2 SCMC2_MOUSE Calcium-binding mitochondrial carrier protein SCaMC-2 2 SZRD1_MOUSE SUZ domain-containing protein 1 2 BBX_MOUSE HMG box transcription factor BBX 2 PKHM1_MOUSE Pleckstrin homology domain-containing family M member 1 2 TM230_MOUSE Transmembrane protein 230 2 PLCE_MOUSE 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon 2 IPO4_MOUSE Importin-4 2 RM21_MOUSE 39S ribosomal protein L21, mitochondrial 2 MARK2_MOUSE Serine/threonine-protein kinase MARK2 2 SMRD3_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily 2 D member 3 TDIF2_MOUSE Deoxynucleotidyltransferase terminal-interacting protein 2 2 REPS1_MOUSE RalBP1-associated Eps domain-containing protein 1 2 SMAP2_MOUSE Stromal membrane-associated protein 2 2 CCD94_MOUSE Coiled-coil domain-containing protein 94 2 RM27_MOUSE 39S ribosomal protein L27, mitochondrial 2 HN1L_MOUSE Hematological and neurological expressed 1-like protein 2 MYOV2_MOUSE Myeloma-overexpressed gene 2 protein homolog 2 UXT_MOUSE Protein UXT 2 TF3C4_MOUSE General transcription factor 3C polypeptide 4 2 MCA3_MOUSE Eukaryotic translation elongation factor 1 epsilon-1 2 CCD50_MOUSE Coiled-coil domain-containing protein 50 2 CMC4_MOUSE Cx9C motif-containing protein 4 2 ANO10_MOUSE Anoctamin-10 2 PSMG1_MOUSE Proteasome assembly chaperone 1 2 P66A_MOUSE Transcriptional repressor p66 alpha 2 PDE12_MOUSE 2',5'-phosphodiesterase 12 2 PQBP1_MOUSE Polyglutamine-binding protein 1 2 FBX4_MOUSE F-box only protein 4 2 HDAC2_MOUSE Histone deacetylase 2 2 CDK7_MOUSE Cyclin-dependent kinase 7 2 MOS1_MOUSE Mitochondrial inner membrane organizing system protein 1 2 E9Q3C1_MOUSE Protein C2cd2 2 PIN4_MOUSE Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 2
EP
Tsc22d1 Aspscr1 Prkcd Sdf2 Rbm15 Mphosph10 Rpe Zeb2 Ap4e1 Crbn Tnrc6b Polr2i Lmf1 Fam175b Pomp Cic Tubgcp3 Yipf4 Obsl1 Stard5 Taf10 Ppie Eml4 Gdpd1 Tma16 Bloc1s1 Mapk3 Fnbp4 Mtg2 Slc25a25 Szrd1 Bbx Plekhm1 Tmem230 Agpat5 Ipo4 Mrpl21 Mark2 Smarcd3 Dnttip2 Reps1 Smap2 Ccdc94 Mrpl27 Hn1l Myeov2 Uxt Gtf3c4 Eef1e1 Ccdc50 Cmc4 Ano10 Psmg1 Gatad2a Pde12 Pqbp1 Fbxo4 Hdac2 Cdk7 Minos1 C2cd2 Pin4
AC C
sp|P62500|T22D1_MOUSE sp|Q8VBT9|ASPC1_MOUSE sp|P28867|KPCD_MOUSE sp|Q9DCT5|SDF2_MOUSE tr|Q0VBL3|Q0VBL3_MOUSE sp|Q810V0|MPP10_MOUSE sp|Q8VEE0|RPE_MOUSE sp|Q9R0G7|ZEB2_MOUSE sp|Q80V94|AP4E1_MOUSE sp|Q8C7D2|CRBN_MOUSE sp|Q8BKI2|TNR6B_MOUSE sp|P60898|RPB9_MOUSE sp|Q3U3R4|LMF1_MOUSE sp|Q3TCJ1|F175B_MOUSE sp|Q9CQT5|POMP_MOUSE sp|Q924A2|CIC_MOUSE sp|P58854|GCP3_MOUSE sp|Q8C407|YIPF4_MOUSE tr|D3YYU8|D3YYU8_MOUSE sp|Q9EPQ7|STAR5_MOUSE sp|Q8K0H5|TAF10_MOUSE sp|Q9QZH3|PPIE_MOUSE sp|Q3UMY5|EMAL4_MOUSE sp|Q9CRY7|GDPD1_MOUSE sp|Q9CR02|TMA16_MOUSE sp|O55102|BL1S1_MOUSE sp|Q63844|MK03_MOUSE sp|Q6ZQ03|FNBP4_MOUSE tr|A2AFK4|A2AFK4_MOUSE sp|A2ASZ8|SCMC2_MOUSE sp|Q6NXN1|SZRD1_MOUSE sp|Q8VBW5|BBX_MOUSE sp|Q7TSI1|PKHM1_MOUSE sp|Q8CIB6|TM230_MOUSE sp|Q9D1E8|PLCE_MOUSE sp|Q8VI75|IPO4_MOUSE sp|Q9D1N9|RM21_MOUSE sp|Q05512|MARK2_MOUSE sp|Q6P9Z1|SMRD3_MOUSE sp|Q8R2M2|TDIF2_MOUSE sp|O54916|REPS1_MOUSE sp|Q7TN29|SMAP2_MOUSE sp|Q9D6J3|CCD94_MOUSE sp|Q99N92|RM27_MOUSE sp|Q6PGH2|HN1L_MOUSE sp|Q3U898|MYOV2_MOUSE sp|Q9WTZ0|UXT_MOUSE sp|Q8BMQ2|TF3C4_MOUSE sp|Q9D1M4|MCA3_MOUSE sp|Q810U5|CCD50_MOUSE sp|Q61908|CMC4_MOUSE sp|Q8BH79|ANO10_MOUSE sp|Q9JK23|PSMG1_MOUSE sp|Q8CHY6|P66A_MOUSE sp|Q3TIU4|PDE12_MOUSE sp|Q91VJ5|PQBP1_MOUSE sp|Q8CHQ0|FBX4_MOUSE sp|P70288|HDAC2_MOUSE sp|Q03147|CDK7_MOUSE sp|Q7TNS2|MOS1_MOUSE tr|E9Q3C1|E9Q3C1_MOUSE sp|Q9CWW6|PIN4_MOUSE
142.573 41.2882 166.638 72.3593 59.2974 168.727 97.2829 113.478 138.752 66.7842 90.1018 33.9756 117.767 91.3888 113.53 134.508 65.7961 96.1851 128.951 105.823 57.3421 62.8295 138.501 64.58 107.465 48.6596 90.3667 37.2401 93.4488 92.6447 215.485 130.644 78.8706 76.721 80.0947 116.301 152.338 92.8471 74.72 112.209 53.7206 38.5177 60.3765 80.6989 60.3753 30.4533 94.9529 134.883 65.3321 50.9417 48.6135 76.4052 71.4433 75.4029 121.921 107.897 340.348 54.4629 64.4318 188.061 121.835 62.168
134.628 126.924 330.312 52.2267 73.906 156.709 55.2146 99.4748 138.533 71.1858 48.0304 178.14 116.761 71.3339 55.5816 85.2299 69.1678 186.966 70.9758 224.831 43.7119 53.3301 163.746 85.0944 94.4598 45.3592 109.202 100.537 33.479 109.886 146.232 212.254 61.7752 62.9339 114.893 150.114 92.6815 90.2347 44.1557 242.305 62.8724 29.0763 42.3988 95.3128 37.1846 41.4875 128.817 121.393 112.847 33.151 63.035 143.8 277.214 93.6193 128.731 76.5962 200.014 75.4235 55.9387 170.544 114.643 58.6956
177.944 215.043 224.391 80.11 119.848 169.021 169.469 243.667 135.568 56.6888 86.8235 521.247 192.823 54.4915 137.3 189.365 48.326 299.803 81.7178 354.021 82.8066 111.634 137.105 90.5148 157.075 76.8098 70.4251 128.21 120.312 89.0259 395.111 263.726 71.5794 51.5697 58.8114 66.9039 116.608 178.746 48.1266 523.932 94.6395 62.7451 55.1487 228.828 75.9826 85.7036 104.83 136.198 105.859 99.6097 129.77 162.198 191.631 208.649 122.627 131.439 675.542 43.0109 65.9633 202.077 163.144 139.273
1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06
1.19 3.55 1.75 1.15 1.60 1.10 1.18 1.55 1.03 0.97 0.80 9.17 1.18 0.71 0.87 1.10 1.03 2.60 0.62 2.66 1.17 1.25 1.23 1.22 1.18 1.07 0.86 2.67 0.71 1.07 1.22 1.98 0.93 0.92 1.15 1.05 0.71 1.48 0.64 3.32 1.51 1.05 0.82 1.83 0.84 1.63 1.25 1.10 1.95 1.28 1.72 1.76 2.66 2.22 1.09 0.79 1.38 1.12 1.02 1.35 1.06 1.37
ACCEPTED MANUSCRIPT
TE D
86.0644 98.336 60.6945 177.337 54.3246 177.082 84.0415 122.52 112.3 87.5244 182.991 120.181 124.044 83.3957 158.706 110.041 62.0516 102.734 76.7829 41.4591 111.277 140.235 83.7824 151.958 29.8587 85.5899 107.101 298.678 43.9697 110.233 77.5663 87.8929 115.758 182.112 119.917 161.356 85.2015 124.835 122.618 44.0809 175.247 123.668 124.791 50.518 174.664 32.4632 38.345 93.6935 201.258 132.023 119.686 126.803 89.1872 59.348 59.2852 76.3357 112.949 150.313 97.9967 59.267 128.587 91.2776
107.368 142.407 63.6341 216.831 47.7481 191.013 127.062 136.285 150.656 109.343 164.732 151.527 145.508 99.7603 193.114 129.005 66.5377 125.426 91.9939 49.4364 144.427 132.855 102.612 205.368 28.6639 91.5261 112.97 338.232 45.7208 131.327 81.7856 96.1705 148.544 205.627 153.806 217.952 107.617 168.931 162.052 54.7838 207.523 136.694 151.711 55.6059 176.164 46.9115 55.9436 114.721 194.131 126.538 146.655 136.193 97.4114 76.9481 65.7297 75.8928 89.8546 100.327 117.254 69.0169 142.196 94.2812
RI PT
97.6084 128.187 50.885 182.723 55.8444 169.225 124.284 166.788 126.463 106.245 152.847 143.223 126.665 88.6217 215.489 105.215 50.9209 117.341 79.0958 48.9982 129.249 112.94 76.3152 195.883 23.0424 77.7428 96.486 281.163 40.4135 136.563 69.1221 91.9755 143.099 213.782 138.309 197.092 98.112 171.08 150.879 49.1754 180.918 124.351 138.818 50.9486 150.479 49.9558 46.8867 109.042 203.326 128.305 131.396 118.206 79.3222 71.2471 54.7496 66.2762 84.3906 88.532 118.498 71.9029 133.943 79.1111
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
GMPPB_MOUSE Mannose-1-phosphate guanyltransferase beta STA5B_MOUSE Signal transducer and activator of transcription 5B MIPEP_MOUSE Mitochondrial intermediate peptidase SBNO1_MOUSE Protein strawberry notch homolog 1 UBP46_MOUSE Ubiquitin carboxyl-terminal hydrolase 46 THOC1_MOUSE THO complex subunit 1 DPP8_MOUSE Dipeptidyl peptidase 8 O88325_MOUSE Alpha-N-acetylglucosaminidase IMP2L_MOUSE Mitochondrial inner membrane protease subunit 2 IRS2_MOUSE Insulin receptor substrate 2 ARI1A_MOUSE AT-rich interactive domain-containing protein 1A DTD2_MOUSE Probable D-tyrosyl-tRNA(Tyr) deacylase 2 MRT4_MOUSE mRNA turnover protein 4 homolog MET17_MOUSE Methyltransferase-like protein 17, mitochondrial GALT2_MOUSE Polypeptide N-acetylgalactosaminyltransferase 2 ATP5S_MOUSE ATP synthase subunit s, mitochondrial E9Q394_MOUSE Protein Akap13 PECR_MOUSE Peroxisomal trans-2-enoyl-CoA reductase HNRH1_MOUSE Heterogeneous nuclear ribonucleoprotein H MINP1_MOUSE Multiple inositol polyphosphate phosphatase 1 ZN346_MOUSE Zinc finger protein 346 GNPTG_MOUSE N-acetylglucosamine-1-phosphotransferase subunit gamma SYWM_MOUSE Tryptophan--tRNA ligase, mitochondrial NEMF_MOUSE Nuclear export mediator factor Nemf TBA3_MOUSE Tubulin alpha-3 chain IKBA_MOUSE NF-kappa-B inhibitor alpha TRIA1_MOUSE TP53-regulated inhibitor of apoptosis 1 TITIN_MOUSE Titin M3K7_MOUSE Mitogen-activated protein kinase kinase kinase 7 MGAT2_MOUSE Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase WASH1_MOUSE WAS protein family homolog 1 UBP10_MOUSE Ubiquitin carboxyl-terminal hydrolase 10 TDRKH_MOUSE Tudor and KH domain-containing protein TYW1_MOUSE S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase ERCC2_MOUSE TFIIH basal transcription factor complex helicase XPD subunit ADIP_MOUSE Afadin- and alpha-actinin-binding protein NUD13_MOUSE Nucleoside diphosphate-linked moiety X motif 13 TPC_MOUSE Mitochondrial thiamine pyrophosphate carrier SRR_MOUSE Serine racemase 2ABD_MOUSE Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform SC5A3_MOUSE Sodium/myo-inositol cotransporter STK16_MOUSE Serine/threonine-protein kinase 16 RM53_MOUSE 39S ribosomal protein L53, mitochondrial GLRX2_MOUSE Glutaredoxin-2, mitochondrial UB2FA_MOUSE NEDD8-conjugating enzyme UBE2F PIGN_MOUSE GPI ethanolamine phosphate transferase 1 STBD1_MOUSE Starch-binding domain-containing protein 1 MARH5_MOUSE E3 ubiquitin-protein ligase MARCH5 GCC1_MOUSE GRIP and coiled-coil domain-containing protein 1 SCRB1_MOUSE Scavenger receptor class B member 1 P4K2A_MOUSE Phosphatidylinositol 4-kinase type 2-alpha CARF_MOUSE CDKN2A-interacting protein RM42_MOUSE 39S ribosomal protein L42, mitochondrial E9Q3R9_MOUSE Protein Zbtb21 FGOP2_MOUSE FGFR1 oncogene partner 2 homolog BRK1_MOUSE Protein BRICK1 AP4A_MOUSE Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] LAR4B_MOUSE La-related protein 4B UBP1_MOUSE Ubiquitin carboxyl-terminal hydrolase 1 GPAT4_MOUSE Glycerol-3-phosphate acyltransferase 4 VWA9_MOUSE von Willebrand factor A domain-containing protein 9 NDUS8_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
EP
Gmppb Stat5b Mipep Sbno1 Usp46 Thoc1 Dpp8 Naglu Immp2l Irs2 Arid1a Dtd2 Mrto4 Mettl17 Galnt2 Atp5s Akap13 Pecr Hnrnph1 Minpp1 Znf346 Gnptg Wars2 Nemf Tuba3a Nfkbia Triap1 Ttn Map3k7 Mgat2 Wash1 Usp10 Tdrkh Tyw1 Ercc2 Ssx2ip Nudt13 Slc25a19 Srr Ppp2r2d Slc5a3 Stk16 Mrpl53 Glrx2 Ube2f Pign Stbd1 05-Mar Gcc1 Scarb1 Pi4k2a Cdkn2aip Mrpl42 Zbtb21 Fgfr1op2 Brk1 Nudt2 Larp4b Usp1 Agpat6 Vwa9 Ndufs8
AC C
sp|Q8BTZ7|GMPPB_MOUSE sp|P42232|STA5B_MOUSE sp|A6H611|MIPEP_MOUSE sp|Q689Z5|SBNO1_MOUSE sp|P62069|UBP46_MOUSE sp|Q8R3N6|THOC1_MOUSE sp|Q80YA7|DPP8_MOUSE tr|O88325|O88325_MOUSE sp|Q8BPT6|IMP2L_MOUSE sp|P81122|IRS2_MOUSE sp|A2BH40|ARI1A_MOUSE sp|Q8BHA3|DTD2_MOUSE sp|Q9D0I8|MRT4_MOUSE sp|Q3U2U7|MET17_MOUSE sp|Q6PB93|GALT2_MOUSE sp|Q9CRA7|ATP5S_MOUSE tr|E9Q394|E9Q394_MOUSE sp|Q99MZ7|PECR_MOUSE sp|O35737|HNRH1_MOUSE sp|Q9Z2L6|MINP1_MOUSE sp|Q9R0B7|ZN346_MOUSE sp|Q6S5C2|GNPTG_MOUSE sp|Q9CYK1|SYWM_MOUSE sp|Q8CCP0|NEMF_MOUSE sp|P05214|TBA3_MOUSE sp|Q9Z1E3|IKBA_MOUSE sp|Q9D8Z2|TRIA1_MOUSE sp|A2ASS6|TITIN_MOUSE sp|Q62073|M3K7_MOUSE sp|Q921V5|MGAT2_MOUSE sp|Q8VDD8|WASH1_MOUSE sp|P52479|UBP10_MOUSE sp|Q80VL1|TDRKH_MOUSE sp|Q8BJM7|TYW1_MOUSE sp|O08811|ERCC2_MOUSE sp|Q8VC66|ADIP_MOUSE sp|Q8JZU0|NUD13_MOUSE sp|Q9DAM5|TPC_MOUSE sp|Q9QZX7|SRR_MOUSE sp|Q925E7|2ABD_MOUSE sp|Q9JKZ2|SC5A3_MOUSE sp|O88697|STK16_MOUSE sp|Q9D1H8|RM53_MOUSE sp|Q923X4|GLRX2_MOUSE sp|Q9CY34|UB2FA_MOUSE sp|Q9R1S3|PIGN_MOUSE sp|Q8C7E7|STBD1_MOUSE sp|Q3KNM2|MARH5_MOUSE sp|Q9D4H2|GCC1_MOUSE sp|Q61009|SCRB1_MOUSE sp|Q2TBE6|P4K2A_MOUSE sp|Q8BI72|CARF_MOUSE sp|Q9CPV3|RM42_MOUSE tr|E9Q3R9|E9Q3R9_MOUSE sp|Q9CRA9|FGOP2_MOUSE sp|Q91VR8|BRK1_MOUSE sp|P56380|AP4A_MOUSE sp|Q6A0A2|LAR4B_MOUSE sp|Q8BJQ2|UBP1_MOUSE sp|Q8K2C8|GPAT4_MOUSE sp|Q8R3P6|VWA9_MOUSE sp|Q8K3J1|NDUS8_MOUSE
87.0296 97.3223 54.4318 164.121 68.7454 174.853 92.5042 168.593 100.912 94.5441 188.634 125.616 118.276 81.0625 200.076 97.1736 52.123 105.691 71.3399 45.1921 106.577 130.999 64.1045 156.69 26.3728 78.3474 98.5839 263.728 41.8801 124.832 70.4675 90.4651 120.023 204.192 113.36 152.865 81.8603 136.806 120.23 41.414 159.815 118.645 119.654 48.8373 158.482 37.8375 31.6497 93.6311 221.35 140.746 111.082 115.306 75.434 56.9218 51.1369 70.1749 112.156 143.972 104.161 65.1057 125.41 79.3772
106.23 97.7986 49.3729 232.914 45.5965 200.195 62.7272 102.712 98.4985 96.2503 180.187 86.634 121.521 73.549 172.718 151.398 65.4917 121.617 80.8225 28.2243 72.4417 55.2241 45.0909 302.042 717.452 54.9043 40.2498 266.033 52.4841 169.851 57.4042 67.3327 64.7031 141.973 141.623 104.989 73.8539 147.482 166.158 30.9514 251.167 119.868 71.0565 28.614 117.128 43.9568 106.441 267.789 162.059 98.1365 145.683 100.527 45.3976 43.2698 42.4878 148.133 58.1849 62.2602 97.7218 99.3723 131.409 61.4428
70.3344 64.2872 66.0377 278.615 39.6464 175.38 71.4472 41.9092 179.559 142.99 223.716 89.4942 154.309 77.3051 161.872 232.307 100.856 92.7819 147.263 13.869 125.835 142.311 50.3999 482.997 678.656 132.439 157.749 350.154 110.208 265.426 123.069 75.7953 159.473 163.663 143.227 232.972 101.666 93.3111 193.611 56.064 230.309 134.503 207.93 87.569 319.499 35.379 2.8527 248.563 284.656 99.9633 75.708 150.254 142.262 81.6265 131.708 293.94 90.8775 101.348 90.9525 127.348 95.0168 51.4286
1.06 1.06 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02
0.96 0.72 1.03 1.42 0.77 1.08 0.64 0.50 1.16 1.23 1.20 0.67 1.10 0.88 0.89 1.78 1.47 0.97 1.46 0.47 0.82 0.78 0.60 2.26 26.39 1.15 0.97 1.06 1.93 1.76 1.23 0.80 0.87 0.77 1.10 0.94 0.96 0.81 1.32 0.93 1.35 1.03 1.06 1.15 1.34 0.96 1.28 2.55 1.10 0.76 0.88 1.02 1.11 0.96 1.53 3.10 0.76 0.68 0.87 1.73 0.86 0.66
ACCEPTED MANUSCRIPT
81.3548 61.6227 89.3863 110.593 86.7299 86.223 146.422 117.275 45.2917 134.344 160.853 125.597 181.148 65.871 51.1078 162.922 169.182 45.5882 133.401 164.534 59.9763 100.524 114.097 91.139 46.3237 125.882 144.126 129.855 64.9918 40.2452 195.908 159.145 94.0227 136.755 31.2726 72.4038 80.5606 70.8971 112.975 106.473 125.798 59.5174 59.2037 147.283 55.6892 99.4282 52.5706 88.0195 92.9744 207.326 77.7164 70.4511 89.1036 92.6199 92.9428 107.83 147.057 145.316 36.6018 89.4878 50.9453 192.934
92.7423 64.5333 110.931 128.549 79.88 80.8919 165.825 159.592 42.695 152.996 186.602 146.114 212.585 61.7243 47.985 142.089 145.691 53.7801 150.038 214.895 64.3517 90.6108 110.704 111.096 62.2835 154.194 148.111 136.012 94.1505 62.8958 210.222 157.248 103.733 164.269 43.418 76.8597 93.1849 85.5627 132.395 113.278 143.506 51.4671 65.1859 153.75 53.9165 120.536 54.6079 90.9831 72.745 222.254 84.9814 85.6282 85.4644 100.821 122.264 122.308 80.4742 180.407 43.5119 120.199 60.9927 194.545
SC
RI PT
85.4018 52.0498 115.156 104.754 75.2872 68.4648 165.039 149.381 39.7994 148.376 162.463 161.622 202.22 57.1174 55.4037 149.557 119.366 47.5298 133.053 204.953 54.2738 84.2893 98.3697 109.209 58.5262 153.129 163.785 110.013 98.6002 59.8833 188.783 122.738 91.3487 156.642 42.6215 73.5941 81.8597 80.942 114.968 117.952 150.163 42.025 55.1379 142.327 52.1499 112.54 58.6604 82.1242 97.1184 212.325 79.3062 77.3822 107.174 88.4157 116.248 117.008 126.139 166.725 40.6997 96.7884 49.8079 175.56
M AN U
TE D
Diaph1 Ints12 Pik3r1 Lsm14b Ppp1cc Reep3 Ccdc9 Armc1 Chkb Slu7 Sugp1 Tacc1 Cmtr1 Pdpk1 Wnk4 Lsm3 Ccdc51 Nudt8 Slc25a42 Vps36 Hmgn1 Irf2 Phf6 Rnf114 Sirt4 Anapc1 Srp14 Agpat4 Dctn6 Lsm1 Exosc9 Pqlc3 Sap30bp Trim33 Ado Xpo4 Nudt12 R3hcc1 Rps29 Prkra Cwc15
KPCE_MOUSE Protein kinase C epsilon type 2 DLGP4_MOUSE Disks large-associated protein 4 2 GGCT_MOUSE Gamma-glutamylcyclotransferase 2 TUSC5_MOUSE Tumor suppressor candidate 5 homolog 2 VPS18_MOUSE Vacuolar protein sorting-associated protein 18 homolog 2 BCL7C_MOUSE B-cell CLL/lymphoma 7 protein family member C 2 HSDL1_MOUSE Inactive hydroxysteroid dehydrogenase-like protein 1 2 PHF8_MOUSE Histone lysine demethylase PHF8 2 DPOLB_MOUSE DNA polymerase beta 2 NUP53_MOUSE Nucleoporin NUP53 2 PPDPF_MOUSE Pancreatic progenitor cell differentiation and proliferation factor 2 AGO4_MOUSE Protein argonaute-4 2 TIAR_MOUSE Nucleolysin TIAR 2 TAP26_MOUSE Thyroid transcription factor 1-associated protein 26 2 BID_MOUSE BH3-interacting domain death agonist 2 KISHB_MOUSE Protein kish-B 2 BIN3_MOUSE Bridging integrator 3 2 NSRP1_MOUSE Nuclear speckle splicing regulatory protein 1 2 CYTSA_MOUSE Cytospin-A 2 TRI36_MOUSE E3 ubiquitin-protein ligase Trim36 2 CJ032_MOUSE UPF0693 protein C10orf32 homolog 2 DIAP1_MOUSE Protein diaphanous homolog 1 2 INT12_MOUSE Integrator complex subunit 12 2 P85A_MOUSE Phosphatidylinositol 3-kinase regulatory subunit alpha 2 LS14B_MOUSE Protein LSM14 homolog B 2 PP1G_MOUSE Isoform Gamma-2 of Serine/threonine-protein phosphatase PP1-gamma catalytic subunit 2 REEP3_MOUSE Receptor expression-enhancing protein 3 2 CCDC9_MOUSE Coiled-coil domain-containing protein 9 2 ARMC1_MOUSE Armadillo repeat-containing protein 1 2 CHKB_MOUSE Choline/ethanolamine kinase 2 SLU7_MOUSE Pre-mRNA-splicing factor SLU7 2 SUGP1_MOUSE SURP and G-patch domain-containing protein 1 2 TACC1_MOUSE Transforming acidic coiled-coil-containing protein 1 2 CMTR1_MOUSE Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 2 PDPK1_MOUSE 3-phosphoinositide-dependent protein kinase 1 2 WNK4_MOUSE Serine/threonine-protein kinase WNK4 2 LSM3_MOUSE U6 snRNA-associated Sm-like protein LSm3 2 CCD51_MOUSE Coiled-coil domain-containing protein 51 2 NUDT8_MOUSE Nucleoside diphosphate-linked moiety X motif 8, mitochondrial 2 S2542_MOUSE Mitochondrial coenzyme A transporter SLC25A42 2 VPS36_MOUSE Vacuolar protein-sorting-associated protein 36 2 HMGN1_MOUSE Non-histone chromosomal protein HMG-14 2 IRF2_MOUSE Interferon regulatory factor 2 2 PHF6_MOUSE PHD finger protein 6 2 RN114_MOUSE E3 ubiquitin-protein ligase RNF114 2 SIR4_MOUSE NAD-dependent protein deacetylase sirtuin-4 2 APC1_MOUSE Anaphase-promoting complex subunit 1 2 SRP14_MOUSE Signal recognition particle 14 kDa protein 2 PLCD_MOUSE 1-acyl-sn-glycerol-3-phosphate acyltransferase delta 2 DCTN6_MOUSE Dynactin subunit 6 2 LSM1_MOUSE U6 snRNA-associated Sm-like protein LSm1 2 EXOS9_MOUSE Exosome complex component RRP45 2 PQLC3_MOUSE PQ-loop repeat-containing protein 3 2 S30BP_MOUSE SAP30-binding protein 2 TRI33_MOUSE E3 ubiquitin-protein ligase TRIM33 2 AEDO_MOUSE 2-aminoethanethiol dioxygenase 2 XPO4_MOUSE Exportin-4 2 NUD12_MOUSE Peroxisomal NADH pyrophosphatase NUDT12 2 R3HC1_MOUSE R3H and coiled-coil domain-containing protein 1 2 RS29_MOUSE 40S ribosomal protein S29 2 PRKRA_MOUSE Interferon-inducible double-stranded RNA-dependent protein kinase activator A 2 CWC15_MOUSE Spliceosome-associated protein CWC15 homolog 2
EP
Prkce Dlgap4 Ggct Tusc5 Vps18 Bcl7c Hsdl1 Phf8 Polb Nup35 Ppdpf Ago4 Tial1 Ccdc59 Bid Tmem167b Bin3 Nsrp1 Specc1l Trim36
AC C
sp|P16054|KPCE_MOUSE sp|B1AZP2|DLGP4_MOUSE sp|Q9D7X8|GGCT_MOUSE sp|Q8C838|TUSC5_MOUSE sp|Q8R307|VPS18_MOUSE sp|O08664|BCL7C_MOUSE sp|Q8BTX9|HSDL1_MOUSE sp|Q80TJ7|PHF8_MOUSE sp|Q8K409|DPOLB_MOUSE sp|Q8R4R6|NUP53_MOUSE sp|Q9CR37|PPDPF_MOUSE sp|Q8CJF8|AGO4_MOUSE sp|P70318|TIAR_MOUSE sp|Q8R2N0|TAP26_MOUSE sp|P70444|BID_MOUSE sp|Q80X45|KISHB_MOUSE sp|Q9JI08|BIN3_MOUSE sp|Q5NCR9|NSRP1_MOUSE sp|Q2KN98|CYTSA_MOUSE sp|Q80WG7|TRI36_MOUSE sp|Q9CRC6|CJ032_MOUSE sp|O08808|DIAP1_MOUSE sp|Q9D168|INT12_MOUSE sp|P26450|P85A_MOUSE sp|Q8CGC4|LS14B_MOUSE sp|P63087-2|PP1G_MOUSE sp|Q99KK1|REEP3_MOUSE sp|Q8VC31|CCDC9_MOUSE sp|Q9D7A8|ARMC1_MOUSE sp|O55229|CHKB_MOUSE sp|Q8BHJ9|SLU7_MOUSE sp|Q8CH02|SUGP1_MOUSE sp|Q6Y685|TACC1_MOUSE sp|Q9DBC3|CMTR1_MOUSE sp|Q9Z2A0|PDPK1_MOUSE sp|Q80UE6|WNK4_MOUSE sp|P62311|LSM3_MOUSE sp|Q3URS9|CCD51_MOUSE sp|Q9CR24|NUDT8_MOUSE sp|Q8R0Y8|S2542_MOUSE sp|Q91XD6|VPS36_MOUSE sp|P18608|HMGN1_MOUSE sp|P23906|IRF2_MOUSE sp|Q9D4J7|PHF6_MOUSE sp|Q9ET26|RN114_MOUSE sp|Q8R216|SIR4_MOUSE sp|P53995|APC1_MOUSE sp|P16254|SRP14_MOUSE sp|Q8K4X7|PLCD_MOUSE sp|Q9WUB4|DCTN6_MOUSE sp|Q8VC85|LSM1_MOUSE sp|Q9JHI7|EXOS9_MOUSE sp|Q8C6U2|PQLC3_MOUSE sp|Q02614|S30BP_MOUSE sp|Q99PP7|TRI33_MOUSE sp|Q6PDY2|AEDO_MOUSE sp|Q9ESJ0|XPO4_MOUSE sp|Q9DCN1|NUD12_MOUSE sp|Q8BSI6|R3HC1_MOUSE sp|P62274|RS29_MOUSE sp|Q9WTX2|PRKRA_MOUSE sp|Q9JHS9|CWC15_MOUSE
77.0071 51.1133 97.0576 90.2844 84.6567 76.1323 150.166 110.912 43.6227 133.712 141.147 145.033 175.974 62.4843 59.5804 173.246 145.223 40.058 118.305 157.078 50.6318 95.3731 103.004 90.2761 42.9603 125.641 160.706 104.479 69.8522 37.4649 175.004 125.016 81.7517 128.955 30.2836 68.6216 68.2977 65.3017 93.8821 109.461 130.299 49.2746 48.2415 133.273 52.8541 89.1319 55.3779 77.2203 114.85 191.632 69.772 59.9711 107.782 77.2791 83.1453 98.4602 186.955 124.74 32.08 61.7793 37.3319 164.92
98.3303 40.079 91.7493 69.5796 87.9683 73.6101 167.465 101.613 35.8024 144.673 63.0893 99.6263 236.461 44.6891 62.5457 200.087 68.4708 45.4416 37.4071 94.2228 33.6408 90.4621 69.0595 69.634 35.5393 140.296 125.466 34.833 76.4494 35.1213 117.869 141.574 41.41 66.9464 46.5842 71.7497 63.1677 85.382 144.719 98.4296 160.566 56.2896 39.9202 149.405 162.862 68.6441 47.4343 69.5144 142.802 186.29 52.1521 84.5896 194.166 50.9467 150.477 72.3407 198.593 209.284 29.4466 149.54 136.73 114.92
124.497 72.8293 137.005 38.0411 75.4315 151.684 147.926 130.775 54.1466 171.937 234.713 82.569 417.925 74.3133 96.1584 261.934 190.327 79.0239 133.32 120.098 66.0911 136.616 190.523 120.346 66.3479 107.29 127.202 28.7784 117.169 24.6234 218.192 216.241 111.185 49.1594 49.3315 166.428 133.066 74.8862 270.928 123.106 168.894 84.1981 35.8175 218.222 294.177 104.427 80.0536 106.499 136.287 404.542 96.6366 57.5477 165.353 140.505 79.1952 119.301 168.26 235.274 49.5475 281.236 213.621 206.566
1.02 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98
1.34 0.99 1.12 0.50 1.01 1.46 1.01 0.87 1.06 1.12 0.92 0.63 1.71 0.97 1.49 1.48 0.90 1.34 0.64 0.58 0.87 1.23 1.22 0.95 0.97 0.89 0.82 0.27 1.18 0.60 0.87 1.27 0.82 0.40 1.30 1.63 1.21 1.06 1.82 0.99 1.19 1.38 0.66 1.27 4.24 0.82 1.15 1.03 1.47 1.41 0.95 0.96 1.83 1.06 1.10 0.85 1.34 1.42 1.02 2.31 3.48 0.87
ACCEPTED MANUSCRIPT
121.356 92.4878 115.235 99.6987 88.4859 134.033 127.574 63.7101 153.447 127.656 112.469 61.6945 49.352 117.907 68.7144 62.1459 103.616 105.318 113.406 123.819 53.3609 72.9646 95.1306 189.926 180.863 71.7828 121.216 136.443 173.988 215.101 72.166 71.2026 106.677 63.5997 78.627 187.401 151.887 208.295 166.335 94.5281 55.5779 108.528 55.9248 103.338 134.981 117.544 99.8074 68.2032 86.6338 91.3658 137.201 39.9702 89.4279 121.593 59.1926 124.167 82.2376 82.0744 54.2563 273.982 150.58 99.8265
157.355 80.002 123.373 119.962 84.5525 104.199 85.3963 67.9958 136.648 137.202 119.46 62.5563 56.9654 113.47 70.6296 61.467 124.716 111.825 130.097 146.768 56.283 83.0596 88.4655 179.366 200.86 64.6922 123.818 157.817 210.075 203.458 66.4849 70.7109 123.536 68.3163 63.4897 172.924 134.643 232.482 151.999 82.3396 58.5172 95.2788 60.5831 114.009 115.66 103.503 84.2963 70.7908 99.2802 68.765 131.565 52.0296 119.521 138.184 66.8429 80.7016 81.5324 78.3151 46.8057 313.883 132.474 111.458
RI PT
144.348 76.6056 96.0541 112.897 90.7222 139.094 87.2812 63.7767 128.898 178.569 113.865 57.8844 56.9109 107.05 67.0361 51.5933 126.63 107.595 131.818 147.366 62.4394 77.673 95.6039 160.365 192.685 66.331 127.222 156.963 231.319 198.683 71.1275 64.1272 123.468 62.0891 94.382 164.145 129.634 223.788 164.594 89.0341 64.2806 94.47 65.3946 108.127 169.125 85.3804 94.6517 78.0304 88.4981 100.228 116.397 54.6848 104.3 137.739 67.2542 67.9865 95.3093 71.2516 39.4406 329.787 134.079 94.1463
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
TE D
Armc6 Fam107b Tmem87b Cdkn2aipnl Ehmt1 Commd10 Cpsf7 Grb2 Rab11fip5 Cmas Rnf20 Fip1l1 Vkorc1l1 Homer1 Med10 Rfk Pum1 Sec23b Gpcpd1 Tbl1x Gsta3 Ccm2 Tmed3 Ncs1 Mrpl35 Tgs1 Stambp Dock9 Gpatch11 Mtpap Mmaa Habp4 Setd1a Srxn1 Stk38l R3hdm1 Snx16 Bap18 Champ1 Wbp4
NPC1_MOUSE Niemann-Pick C1 protein RBM7_MOUSE RNA-binding protein 7 FKBPL_MOUSE FK506-binding protein-like CNOT3_MOUSE CCR4-NOT transcription complex subunit 3 DNJC9_MOUSE DnaJ homolog subfamily C member 9 STT3B_MOUSE Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B MKLN1_MOUSE Muskelin PHF5A_MOUSE PHD finger-like domain-containing protein 5A CSTFT_MOUSE Cleavage stimulation factor subunit 2 tau variant XPO7_MOUSE Exportin-7 SFSWA_MOUSE Splicing factor, suppressor of white-apricot homolog RBM4_MOUSE RNA-binding protein 4 QPCTL_MOUSE Glutaminyl-peptide cyclotransferase-like protein RMD3_MOUSE Regulator of microtubule dynamics protein 3 ZFY19_MOUSE Zinc finger FYVE domain-containing protein 19 CC104_MOUSE Coiled-coil domain-containing protein 104 HP1B3_MOUSE Isoform 2 of Heterochromatin protein 1-binding protein 3 NT5D3_MOUSE 5'-nucleotidase domain-containing protein 3 IFI5A_MOUSE Interferon-activable protein 205-A NAA40_MOUSE N-alpha-acetyltransferase 40 WDR4_MOUSE tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 CQ089_MOUSE Uncharacterized protein C17orf89 homolog ARMC6_MOUSE Armadillo repeat-containing protein 6 F107B_MOUSE Protein FAM107B TM87B_MOUSE Transmembrane protein 87B C2AIL_MOUSE CDKN2AIP N-terminal-like protein EHMT1_MOUSE Histone-lysine N-methyltransferase EHMT1 COMDA_MOUSE COMM domain-containing protein 10 CPSF7_MOUSE Cleavage and polyadenylation specificity factor subunit 7 GRB2_MOUSE Growth factor receptor-bound protein 2 RFIP5_MOUSE Rab11 family-interacting protein 5 NEUA_MOUSE N-acylneuraminate cytidylyltransferase BRE1A_MOUSE E3 ubiquitin-protein ligase BRE1A FIP1_MOUSE Pre-mRNA 3'-end-processing factor FIP1 VKORL_MOUSE Vitamin K epoxide reductase complex subunit 1-like protein 1 HOME1_MOUSE Homer protein homolog 1 MED10_MOUSE Mediator of RNA polymerase II transcription subunit 10 RIFK_MOUSE Riboflavin kinase PUM1_MOUSE Pumilio homolog 1 SC23B_MOUSE Protein transport protein Sec23B GPCP1_MOUSE Glycerophosphocholine phosphodiesterase GPCPD1 TBL1X_MOUSE F-box-like/WD repeat-containing protein TBL1X GSTA3_MOUSE Glutathione S-transferase A3 CCM2_MOUSE Malcavernin TMED3_MOUSE Transmembrane emp24 domain-containing protein 3 NCS1_MOUSE Neuronal calcium sensor 1 RM35_MOUSE 39S ribosomal protein L35, mitochondrial TGS1_MOUSE Trimethylguanosine synthase STABP_MOUSE STAM-binding protein DOCK9_MOUSE Dedicator of cytokinesis protein 9 GPT11_MOUSE G patch domain-containing protein 11 PAPD1_MOUSE Poly(A) RNA polymerase, mitochondrial MMAA_MOUSE Methylmalonic aciduria type A homolog, mitochondrial HABP4_MOUSE Intracellular hyaluronan-binding protein 4 E9PYH6_MOUSE Protein Setd1a SRXN1_MOUSE Sulfiredoxin-1 ST38L_MOUSE Serine/threonine-protein kinase 38-like E9Q9Q2_MOUSE Protein R3hdm1 SNX16_MOUSE Sorting nexin-16 BAP18_MOUSE Chromatin complexes subunit BAP18 CHAP1_MOUSE Chromosome alignment-maintaining phosphoprotein 1 WBP4_MOUSE WW domain-binding protein 4
EP
Npc1 Rbm7 Fkbpl Cnot3 Dnajc9 Stt3b Mkln1 Phf5a Cstf2t Xpo7 Sfswap Rbm4 Qpctl Rmdn3 Zfyve19 Ccdc104 Hp1bp3 Nt5dc3 Ifi205a Naa40 Wdr4
AC C
sp|O35604|NPC1_MOUSE sp|Q9CQT2|RBM7_MOUSE sp|O35450|FKBPL_MOUSE sp|Q8K0V4|CNOT3_MOUSE sp|Q91WN1|DNJC9_MOUSE sp|Q3TDQ1|STT3B_MOUSE sp|O89050|MKLN1_MOUSE sp|P83870|PHF5A_MOUSE sp|Q8C7E9|CSTFT_MOUSE sp|Q9EPK7|XPO7_MOUSE sp|Q3USH5|SFSWA_MOUSE sp|Q8C7Q4|RBM4_MOUSE sp|Q8BH73|QPCTL_MOUSE sp|Q3UJU9|RMD3_MOUSE sp|Q9DAZ9|ZFY19_MOUSE sp|Q8C6E0|CC104_MOUSE sp|Q3TEA8-2|HP1B3_MOUSE sp|Q3UHB1|NT5D3_MOUSE sp|Q8CGE8|IFI5A_MOUSE sp|Q8VE10|NAA40_MOUSE sp|Q9EP82|WDR4_MOUSE sp|A2AMZ4|CQ089_MOUSE sp|Q8BNU0|ARMC6_MOUSE sp|Q3TGF2|F107B_MOUSE sp|Q8BKU8|TM87B_MOUSE sp|Q9D211|C2AIL_MOUSE sp|Q5DW34|EHMT1_MOUSE sp|Q8JZY2|COMDA_MOUSE sp|Q8BTV2|CPSF7_MOUSE sp|Q60631|GRB2_MOUSE sp|Q8R361|RFIP5_MOUSE sp|Q99KK2|NEUA_MOUSE sp|Q5DTM8|BRE1A_MOUSE sp|Q9D824|FIP1_MOUSE sp|Q6TEK5|VKORL_MOUSE sp|Q9Z2Y3|HOME1_MOUSE sp|Q9CXU0|MED10_MOUSE sp|Q8CFV9|RIFK_MOUSE sp|Q80U78|PUM1_MOUSE sp|Q9D662|SC23B_MOUSE sp|Q8C0L9|GPCP1_MOUSE sp|Q9QXE7|TBL1X_MOUSE sp|P30115|GSTA3_MOUSE sp|Q8K2Y9|CCM2_MOUSE sp|Q78IS1|TMED3_MOUSE sp|Q8BNY6|NCS1_MOUSE sp|Q9CQL6|RM35_MOUSE sp|Q923W1|TGS1_MOUSE sp|Q9CQ26|STABP_MOUSE sp|Q8BIK4|DOCK9_MOUSE sp|Q3UFS4|GPT11_MOUSE sp|Q9D0D3|PAPD1_MOUSE sp|Q8C7H1|MMAA_MOUSE sp|Q9JKS5|HABP4_MOUSE tr|E9PYH6|E9PYH6_MOUSE sp|Q9D975|SRXN1_MOUSE sp|Q7TSE6|ST38L_MOUSE tr|E9Q9Q2|E9Q9Q2_MOUSE sp|Q8C080|SNX16_MOUSE sp|Q9DCT6|BAP18_MOUSE sp|Q8K327|CHAP1_MOUSE sp|Q61048|WBP4_MOUSE
101.837 84.8719 82.4176 86.9063 89.6281 161.218 123.246 55.6539 137.154 159.741 99.8434 53.1743 45.851 104.096 60.6289 48.3973 97.6435 93.6057 106.379 114.201 55.05 61.6584 94.1204 155.515 156.002 67.2284 113.224 122.074 176.28 190.815 69.9066 57.9037 94.9756 51.015 100.565 160.294 132.139 176.865 161.386 91.4373 54.9454 96.8483 54.1202 85.9157 171.519 87.9208 99.068 66.9682 65.5503 111.517 107.06 37.0256 62.3558 105.184 51.5422 99.1307 84.4569 64.678 40.5692 248.822 132.615 69.1257
170.454 103.173 73.7365 97.355 159.418 125.957 83.9736 94.1868 97.5026 165.332 114.987 63.1893 65.3695 366.918 49.0142 165.531 42.0048 103.169 25.1666 135.382 45.5557 59.8908 120.261 172.758 201.246 58.1762 154.108 129.345 151.199 166.07 124.672 282.13 70.9661 66.04 79.5094 177.729 91.6264 156.246 108.368 107.648 103.468 116.997 146.15 55.1722 106.196 83.9974 73.9436 93.5117 62.1147 92.416 157.782 74.7049 39.4563 52.9203 37.0295 105.04 102.606 57.2099 43.447 192.991 126.026 79.4734
102.22 150.891 162.631 123.679 209.172 106.428 151.313 236.13 170.265 115.908 162.611 116.276 35.8583 543.605 101.618 370.051 65.05 90.6629 33.0124 94.0203 42.5825 76.2584 102.153 351.726 113.288 109.185 227.977 137.256 137.775 311.587 166.913 249.836 126.506 124.7 99.1635 364.574 301.761 307.742 143.509 83.0119 115.841 250.987 553.937 98.5069 88.6123 125.659 255.89 111.318 95.5273 89.9948 256.404 61.7875 46.4295 131.618 54.0182 311.601 79.7899 168.286 68.3065 375.37 235.3 150.02
0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.95 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.93 0.93 0.93 0.93 0.93 0.93
1.03 1.50 1.12 1.04 2.06 0.85 1.10 2.59 0.95 0.92 1.23 1.50 0.95 4.05 1.11 4.71 0.46 0.91 0.24 0.85 0.76 0.90 1.17 1.50 0.84 1.21 1.54 0.91 0.71 1.15 2.03 3.93 0.86 1.52 1.03 1.54 1.40 1.07 0.76 1.04 1.83 1.81 5.77 0.73 0.64 1.03 1.70 1.40 0.90 0.95 1.63 1.44 0.44 0.71 0.72 2.17 1.03 1.47 1.19 0.94 1.27 1.18
ACCEPTED MANUSCRIPT
Csnk2a2 Decr2 Nkap Pnkp Rprd1b Tor1aip2
150.252 178.189 49.497 161.643 136.125 130.926 79.0185 96.8403 158.625 170.009 31.1295 140.043 198.946 163.69 71.6367 82.6843 115.956 98.449 39.5846 88.9499 73.3555 87.0827 91.105 148.958 46.6783 77.4788 158.567 77.1652 115.989 44.4674 104.376 103.777 90.0306 43.8957 70.8593 89.1221 92.4807 169.87 59.4854 169.989 78.991 117.661 113.524 115.01 131.499 95.6636 90.1287 87.9814 99.3047 103.756 83.403 93.5696 176.783 143.509 78.4537 182.827 84.6749 90.8978 75.1725 74.0666 120.974 83.7381
184.411 175.539 53.5045 149.551 128.914 112.843 86.6037 100.132 177.325 221.752 36.3742 94.8195 179.079 187.109 67.1676 61.9774 119.292 97.5417 44.1046 97.4063 61.4296 90.3008 68.2392 113.612 40.4958 84.1498 113.983 74.5249 131.923 46.0946 106.147 103.354 82.4488 45.3532 68.4451 89.6737 89.0337 125.699 54.5549 180.498 78.8416 115.7 120.407 85.6587 105.095 77.7769 78.6056 92.4344 84.3648 106.897 86.4503 144.969 146.051 137.093 83.7764 180.203 74.4645 75.2292 76.1388 77.7824 118.997 83.2348
RI PT
205.274 226.576 51.3335 147.068 135.05 116.342 97.8315 89.894 172.673 237.142 39.393 115.238 183.201 197.299 63.514 108.851 134.589 126.894 39.1617 131.781 59.8118 94.9788 73.5599 116.114 42.8989 86.0655 105.097 73.4285 122.51 50.2544 89.8427 107.378 90.1727 44.4336 59.9188 98.4151 93.3751 124.053 50.6392 173.193 81.0041 125.326 119.673 90.1328 150.876 112.814 81.8797 95.2006 107.254 120.382 101.152 185.82 209.392 159.052 91.7666 176.231 97.8976 91.6638 82.0525 76.8623 122.78 97.1795
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
M AN U
TE D
Znf512b Gaa Ulk3 Mgrn1 Map3k2 Med7 Kctd5 Fam172a Rbm6 Zeb1 Stx18 Tprkb Pafah1b3 Dffa Polr2f Mapk8ip3 Dpf2 Ppp4c Pdcl Pdcl3 Tnip1 Atp6v1f Znf516 Arsk Gtf2f2 Gfer Snrpd1 Uqcc1 Max Tp53bp2 Ccdc93 Nt5c3b Ctbp2 Add1 Nxn Nptn Cr1l
Q6XPS7_MOUSE L-threonine aldolase CPSF1_MOUSE Cleavage and polyadenylation specificity factor subunit 1 ZHX1_MOUSE Zinc fingers and homeoboxes protein 1 CHM2B_MOUSE Charged multivesicular body protein 2b IFT27_MOUSE Intraflagellar transport protein 27 homolog BCAR3_MOUSE Breast cancer anti-estrogen resistance protein 3 VPS28_MOUSE Vacuolar protein sorting-associated protein 28 homolog RU1C_MOUSE U1 small nuclear ribonucleoprotein C RABX5_MOUSE Rab5 GDP/GTP exchange factor TPC13_MOUSE Trafficking protein particle complex subunit 13 MCU_MOUSE Calcium uniporter protein, mitochondrial YTHD2_MOUSE YTH domain-containing family protein 2 STAR7_MOUSE StAR-related lipid transfer protein 7, mitochondrial PRP4_MOUSE U4/U6 small nuclear ribonucleoprotein Prp4 NDEL1_MOUSE Nuclear distribution protein nudE-like 1 CP1B1_MOUSE Cytochrome P450 1B1 KS6A4_MOUSE Ribosomal protein S6 kinase alpha-4 CT027_MOUSE UPF0687 protein C20orf27 homolog B7ZCR6_MOUSE Protein Znf512b LYAG_MOUSE Lysosomal alpha-glucosidase ULK3_MOUSE Serine/threonine-protein kinase ULK3 MGRN1_MOUSE E3 ubiquitin-protein ligase MGRN1 M3K2_MOUSE Mitogen-activated protein kinase kinase kinase 2 MED7_MOUSE Mediator of RNA polymerase II transcription subunit 7 KCTD5_MOUSE BTB/POZ domain-containing protein KCTD5 F172A_MOUSE Protein FAM172A Q3ULB0_MOUSE Protein Rbm6 ZEB1_MOUSE Zinc finger E-box-binding homeobox 1 STX18_MOUSE Syntaxin-18 TPRKB_MOUSE EKC/KEOPS complex subunit Tprkb PA1B3_MOUSE Platelet-activating factor acetylhydrolase IB subunit gamma DFFA_MOUSE Isoform ICAD-S of DNA fragmentation factor subunit alpha RPAB2_MOUSE DNA-directed RNA polymerases I, II, and III subunit RPABC2 JIP3_MOUSE C-Jun-amino-terminal kinase-interacting protein 3 REQU_MOUSE Zinc finger protein ubi-d4 PP4C_MOUSE Serine/threonine-protein phosphatase 4 catalytic subunit PHLP_MOUSE Phosducin-like protein PDCL3_MOUSE Phosducin-like protein 3 TNIP1_MOUSE TNFAIP3-interacting protein 1 VATF_MOUSE V-type proton ATPase subunit F ZN516_MOUSE Zinc finger protein 516 ARSK_MOUSE Arylsulfatase K T2FB_MOUSE General transcription factor IIF subunit 2 ALR_MOUSE FAD-linked sulfhydryl oxidase ALR SMD1_MOUSE Small nuclear ribonucleoprotein Sm D1 UQCC1_MOUSE Ubiquinol-cytochrome-c reductase complex assembly factor 1 MAX_MOUSE Protein max ASPP2_MOUSE Apoptosis-stimulating of p53 protein 2 CCD93_MOUSE Coiled-coil domain-containing protein 93 5NT3B_MOUSE 7-methylguanosine phosphate-specific 5'-nucleotidase CTBP2_MOUSE C-terminal-binding protein 2 ADDA_MOUSE Alpha-adducin NXN_MOUSE Nucleoredoxin NPTN_MOUSE Neuroplastin CR1L_MOUSE Complement component receptor 1-like protein CA122_MOUSE Uncharacterized protein C1orf122 homolog CSK22_MOUSE Casein kinase II subunit alpha' DECR2_MOUSE Peroxisomal 2,4-dienoyl-CoA reductase NKAP_MOUSE NF-kappa-B-activating protein PNKP_MOUSE Bifunctional polynucleotide phosphatase/kinase RPR1B_MOUSE Regulation of nuclear pre-mRNA domain-containing protein 1B TOIP2_MOUSE Torsin-1A-interacting protein 2
EP
Tha1 Cpsf1 Zhx1 Chmp2b Ift27 Bcar3 Vps28 Snrpc Rabgef1 Trappc13 Mcu Ythdf2 Stard7 Prpf4 Ndel1 Cyp1b1 Rps6ka4
AC C
tr|Q6XPS7|Q6XPS7_MOUSE sp|Q9EPU4|CPSF1_MOUSE sp|P70121|ZHX1_MOUSE sp|Q8BJF9|CHM2B_MOUSE sp|Q9D0P8|IFT27_MOUSE sp|Q9QZK2|BCAR3_MOUSE sp|Q9D1C8|VPS28_MOUSE sp|Q62241|RU1C_MOUSE sp|Q9JM13|RABX5_MOUSE sp|Q3TIR1|TPC13_MOUSE sp|Q3UMR5|MCU_MOUSE sp|Q91YT7|YTHD2_MOUSE sp|Q8R1R3|STAR7_MOUSE sp|Q9DAW6|PRP4_MOUSE sp|Q9ERR1|NDEL1_MOUSE sp|Q64429|CP1B1_MOUSE sp|Q9Z2B9|KS6A4_MOUSE sp|Q9D1K7|CT027_MOUSE tr|B7ZCR6|B7ZCR6_MOUSE sp|P70699|LYAG_MOUSE sp|Q3U3Q1|ULK3_MOUSE sp|Q9D074|MGRN1_MOUSE sp|Q61083|M3K2_MOUSE sp|Q9CZB6|MED7_MOUSE sp|Q8VC57|KCTD5_MOUSE sp|Q3TNH5|F172A_MOUSE tr|Q3ULB0|Q3ULB0_MOUSE sp|Q64318|ZEB1_MOUSE sp|Q8VDS8|STX18_MOUSE sp|Q8QZZ7|TPRKB_MOUSE sp|Q61205|PA1B3_MOUSE sp|O54786-2|DFFA_MOUSE sp|P61219|RPAB2_MOUSE sp|Q9ESN9|JIP3_MOUSE sp|Q61103|REQU_MOUSE sp|P97470|PP4C_MOUSE sp|Q9DBX2|PHLP_MOUSE sp|Q8BVF2|PDCL3_MOUSE sp|Q9WUU8|TNIP1_MOUSE sp|Q9D1K2|VATF_MOUSE sp|Q7TSH3|ZN516_MOUSE sp|Q9D2L1|ARSK_MOUSE sp|Q8R0A0|T2FB_MOUSE sp|P56213|ALR_MOUSE sp|P62315|SMD1_MOUSE sp|Q9CWU6|UQCC1_MOUSE sp|P28574|MAX_MOUSE sp|Q8CG79|ASPP2_MOUSE sp|Q7TQK5|CCD93_MOUSE sp|Q3UFY7|5NT3B_MOUSE sp|P56546|CTBP2_MOUSE sp|Q9QYC0|ADDA_MOUSE sp|P97346|NXN_MOUSE sp|P97300|NPTN_MOUSE sp|Q64735|CR1L_MOUSE sp|B1ARW8|CA122_MOUSE sp|O54833|CSK22_MOUSE sp|Q9WV68|DECR2_MOUSE sp|Q9D0F4|NKAP_MOUSE sp|Q9JLV6|PNKP_MOUSE sp|Q9CSU0|RPR1B_MOUSE sp|Q8BYU6|TOIP2_MOUSE
146.571 201.279 40.3628 137.59 123.256 116.606 77.3022 72.5772 128.798 154.353 28.7379 140.577 173.164 145.588 56.8535 113.466 110.192 108.1 27.7241 103.932 60.0112 75.5898 81.7303 127.503 40.9386 64.4147 125.526 62.245 84.6556 39.7978 69.6431 87.7392 80.2859 34.3823 49.5789 79.4507 78.4922 139.098 44.6331 128.361 64.9036 102.514 88.663 98.2519 147.421 108.639 75.1578 70.8646 99.6399 92.6509 77.7163 102.953 196.173 130.671 66.7338 136.659 86.4866 85.6378 62.2795 54.6531 94.8464 75.3317
74.2861 167.583 35.6947 79.5061 101.098 80.9678 72.3152 74.449 155.623 180.506 61.587 113.34 134.642 190.826 52.364 25.6255 93.0366 51.924 24.771 39.2233 131.41 45.1791 70.5146 84.4978 39.3018 61.0993 119.785 44.4073 106.473 42.6001 113.725 59.6469 65.7515 99.7955 63.3047 39.8685 81.5521 174.272 25.7704 87.4266 129.096 59.2756 114.944 87.5642 96.0089 138.096 38.9636 69.0672 84.7711 95.5257 71.3432 76.2632 220.658 125.091 72.0237 31.9254 83.8009 118.679 58.016 120.695 108.392 81.1782
184.76 157.904 91.1124 135.184 243.684 126.755 89.4785 242.86 197.207 201.28 22.9295 132.754 234.835 226.157 89.3168 45.7129 75.3181 90.6746 51.1078 65.0721 168.217 45.3568 78.8007 163.043 46.8515 71.9459 276.263 75.5446 152.082 43.6304 135.338 108.673 140.694 105.494 107.137 59.8851 135.939 365.754 44.4596 190.135 203.882 117.613 170.9 186.512 84.4245 101.272 134.955 153.741 82.5166 97.4924 72.509 102.471 163.753 154.511 76.3948 117.429 62.9369 145.612 137.652 142.579 153.603 78.0804
0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88
0.73 0.80 1.26 0.70 1.27 0.84 0.91 1.70 1.06 0.94 1.20 0.96 0.97 1.16 1.05 0.37 0.67 0.63 0.96 0.47 2.25 0.50 0.91 0.93 0.96 0.81 1.50 0.80 1.08 0.91 1.28 0.80 1.15 2.32 1.30 0.53 1.17 1.84 0.64 0.81 2.08 0.73 1.23 1.34 0.64 1.15 1.01 1.22 0.81 0.86 0.78 0.64 1.00 0.92 0.87 0.42 0.80 1.45 1.24 1.74 1.07 0.88
ACCEPTED MANUSCRIPT
49.0077 169.578 55.3133 78.2997 98.7341 192.147 147.395 77.1841 76.7499 239.119 98.9307 100.562 74.0371 228.115 130.827 100.498 177.442 151.074 126.112 51.7852 192.139 155.026 78.9504 87.2183 164.232 74.7189 58.5577 75.3006 130.151 123.815 135.407 80.9954 242.886 68.9214 108.74 291.02 122.123 123.134 112.411 77.8416 143.862 142.808 164.135 171.407 112.354 120.017 239.593 117.527 217.902 77.5379 138.361 223.761 87.1995 111.771 161.788 175.671 63.4987 79.0754 110.586 96.0215 135.529 111.46
45.1856 140.045 53.7918 61.0728 107.782 183.576 116.007 92.1709 46.5883 213.728 95.208 94.7792 59.7612 154.485 120.083 88.4183 210.699 132.772 48.8878 50.5307 166.272 115.421 80.1249 96.0227 140.13 51.7437 56.2118 80.2808 119.292 100.864 116.46 60.3304 231.226 72.584 106.975 183.768 122.11 97.8884 99.9329 68.7451 117.057 107.267 152.005 139.158 99.116 92.204 221.556 98.8907 187.188 53.3993 93.1403 182.645 73.293 93.0547 160.221 157.576 67.9354 72.0098 98.5888 76.6743 104.128 95.4465
RI PT
SC
M AN U
TE D
Ube2b Hddc3 Pxdn Pygo2 Jund Whsc1l1 Stxbp2 Nfic Trappc2 Dopey2 Acbd6 Eif4ebp2 Snx27 Ikbip Dda1 Atf7ip Vps51 Guk1 Tpd52 Ogfod1 Cav2 Mbd2 Ube2g1 Chmp3 Stx17 Irf3 Fnbp1l Pfn2 Cdc23 Tbl1xr1 Col8a1 Srsf3 Gm16286 Plod2 Cpne3 Art3 Ankrd49 Strn3 Wasl Pisd Efhd2
BCKD_MOUSE [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2 55.2729 RBMS2_MOUSE RNA-binding motif, single-stranded-interacting protein 2 2 135.619 UBE2Z_MOUSE Ubiquitin-conjugating enzyme E2 Z 2 53.7816 PTEN_MOUSE Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase 2 PTEN 74.6091 PDP1_MOUSE [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial 2 130.838 G3UVU2_MOUSE Splicing factor 3A subunit 2 2 205.325 SON_MOUSE Protein SON 2 131.04 NF1_MOUSE Neurofibromin 2 98.6315 TMM33_MOUSE Transmembrane protein 33 2 84.2241 SFR1_MOUSE Swi5-dependent recombination DNA repair protein 1 homolog 2 193.11 ARHL2_MOUSE Poly(ADP-ribose) glycohydrolase ARH3 2 104.451 LTOR1_MOUSE Ragulator complex protein LAMTOR1 2 98.04 NDUS6_MOUSE NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial 2 61.5454 S4R2E2_MOUSE Protein PRRC2C (Fragment) 2 110.583 EOGT_MOUSE EGF domain-specific O-linked N-acetylglucosamine transferase 2 152.961 SMU1_MOUSE WD40 repeat-containing protein SMU1 2 115.763 E9PY42_MOUSE Protein Eci3 (Fragment) 2 196.844 THOC6_MOUSE THO complex subunit 6 homolog 2 162.457 TM135_MOUSE Transmembrane protein 135 2 116.671 F7CVJ5_MOUSE Protein Ahnak2 (Fragment) 2 45.94 ASHWN_MOUSE Ashwin 2 181.255 UBE2B_MOUSE Ubiquitin-conjugating enzyme E2 B 2 115.193 MESH1_MOUSE Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 2 78.2729 PXDN_MOUSE Peroxidasin homolog 2 98.0476 Q80V76_MOUSE Protein Pygo2 2 132.193 JUND_MOUSE Transcription factor jun-D 2 46.93 NSD3_MOUSE Histone-lysine N-methyltransferase NSD3 2 57.2488 STXB2_MOUSE Syntaxin-binding protein 2 2 100.141 NFIC_MOUSE Nuclear factor 1 C-type 2 163.979 TPPC2_MOUSE Trafficking protein particle complex subunit 2 2 152.077 DOP2_MOUSE Protein dopey-2 2 100.156 ACBD6_MOUSE Acyl-CoA-binding domain-containing protein 6 2 60.5405 4EBP2_MOUSE Eukaryotic translation initiation factor 4E-binding protein 2 2 245.505 SNX27_MOUSE Sorting nexin-27 2 92.6277 IKIP_MOUSE Inhibitor of nuclear factor kappa-B kinase-interacting protein 2 119.708 DDA1_MOUSE DET1- and DDB1-associated protein 1 2 185.071 MCAF1_MOUSE Activating transcription factor 7-interacting protein 1 2 160.353 VPS51_MOUSE Vacuolar protein sorting-associated protein 51 homolog 2 146.264 KGUA_MOUSE Guanylate kinase 2 98.8484 TPD52_MOUSE Tumor protein D52 2 68.3608 OGFD1_MOUSE Prolyl 3-hydroxylase OGFOD1 2 137.765 CAV2_MOUSE Caveolin-2 2 165.828 MBD2_MOUSE Methyl-CpG-binding domain protein 2 2 165.463 UB2G1_MOUSE Ubiquitin-conjugating enzyme E2 G1 2 142.855 CHMP3_MOUSE Charged multivesicular body protein 3 2 108.577 STX17_MOUSE Syntaxin-17 2 121.114 IRF3_MOUSE Interferon regulatory factor 3 2 244.011 FBP1L_MOUSE Formin-binding protein 1-like 2 105.255 PROF2_MOUSE Profilin-2 2 217.213 CDC23_MOUSE Cell division cycle protein 23 homolog 2 76.9202 TBL1R_MOUSE F-box-like/WD repeat-containing protein TBL1XR1 2 115.731 CO8A1_MOUSE Collagen alpha-1(VIII) chain 2 228.796 SRSF3_MOUSE Serine/arginine-rich splicing factor 3 2 90.7966 Q9CQX6_MOUSE MCG141091, isoform CRA_a 2 110.988 PLOD2_MOUSE Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 2 185.814 CPNE3_MOUSE Copine-3 2 177.041 NAR3_MOUSE Ecto-ADP-ribosyltransferase 3 2 74.9439 ANR49_MOUSE Ankyrin repeat domain-containing protein 49 2 78.6871 STRN3_MOUSE Striatin-3 2 136.183 WASL_MOUSE Neural Wiskott-Aldrich syndrome protein 2 96.1028 PISD_MOUSE Phosphatidylserine decarboxylase proenzyme 2 126.805 EFHD2_MOUSE EF-hand domain-containing protein D2 2 103.528
EP
Bckdk Rbms2 Ube2z Pten Pdp1 Sf3a2 Son Nf1 Tmem33 Sfr1 Adprhl2 Lamtor1 Ndufs6 Prrc2c Eogt Smu1 Eci3 Thoc6 Tmem135 Ahnak2
AC C
sp|O55028|BCKD_MOUSE sp|Q8VC70|RBMS2_MOUSE sp|Q3UE37|UBE2Z_MOUSE sp|O08586|PTEN_MOUSE sp|Q3UV70|PDP1_MOUSE tr|G3UVU2|G3UVU2_MOUSE sp|Q9QX47|SON_MOUSE sp|Q04690|NF1_MOUSE sp|Q9CR67|TMM33_MOUSE sp|Q8BP27|SFR1_MOUSE sp|Q8CG72|ARHL2_MOUSE sp|Q9CQ22|LTOR1_MOUSE sp|P52503|NDUS6_MOUSE tr|S4R2E2|S4R2E2_MOUSE sp|Q8BYW9|EOGT_MOUSE sp|Q3UKJ7|SMU1_MOUSE tr|E9PY42|E9PY42_MOUSE sp|Q5U4D9|THOC6_MOUSE sp|Q9CYV5|TM135_MOUSE tr|F7CVJ5|F7CVJ5_MOUSE sp|Q922M7|ASHWN_MOUSE sp|P63147|UBE2B_MOUSE sp|Q9D114|MESH1_MOUSE sp|Q3UQ28|PXDN_MOUSE tr|Q80V76|Q80V76_MOUSE sp|P15066|JUND_MOUSE sp|Q6P2L6|NSD3_MOUSE sp|Q64324|STXB2_MOUSE sp|P70255|NFIC_MOUSE sp|Q9CQP2|TPPC2_MOUSE sp|Q3UHQ6|DOP2_MOUSE sp|Q9D061|ACBD6_MOUSE sp|P70445|4EBP2_MOUSE sp|Q3UHD6|SNX27_MOUSE sp|Q9DBZ1|IKIP_MOUSE sp|Q9D9Z5|DDA1_MOUSE sp|Q7TT18|MCAF1_MOUSE sp|Q3UVL4|VPS51_MOUSE sp|Q64520|KGUA_MOUSE sp|Q62393|TPD52_MOUSE sp|Q3U0K8|OGFD1_MOUSE sp|Q9WVC3|CAV2_MOUSE sp|Q9Z2E1|MBD2_MOUSE sp|P62254|UB2G1_MOUSE sp|Q9CQ10|CHMP3_MOUSE sp|Q9D0I4|STX17_MOUSE sp|P70671|IRF3_MOUSE sp|Q8K012|FBP1L_MOUSE sp|Q9JJV2|PROF2_MOUSE sp|Q8BGZ4|CDC23_MOUSE sp|Q8BHJ5|TBL1R_MOUSE sp|Q00780|CO8A1_MOUSE sp|P84104|SRSF3_MOUSE tr|Q9CQX6|Q9CQX6_MOUSE sp|Q9R0B9|PLOD2_MOUSE sp|Q8BT60|CPNE3_MOUSE sp|Q8R2G4|NAR3_MOUSE sp|Q8VE42|ANR49_MOUSE sp|Q9ERG2|STRN3_MOUSE sp|Q91YD9|WASL_MOUSE sp|Q8BSF4|PISD_MOUSE sp|Q9D8Y0|EFHD2_MOUSE
46.1423 126.894 41.5657 72.0381 91.9923 161.691 125.813 59.8307 92.3814 158.927 79.7615 75.7187 56.4632 135.218 122.591 96.3915 108.403 134.372 157.437 32.5173 150.963 113.984 53.1382 60.8926 110.032 50.7618 41.203 67.1781 127.877 130.728 80.9128 58.1941 177.753 62.2788 83.4715 212.746 112.782 126.019 75.5621 51.4477 114.148 146.03 118.485 118.746 81.9193 105.041 173.859 82.6826 166.232 71.6663 111.683 179.831 68.9657 84.5924 116.952 120.431 40.8694 51.5159 93.8806 72.6362 99.2612 70.1889
172.762 72.8765 44.504 57.31 120.273 149.99 225.541 73.6336 79.7187 33.8144 388.047 59.9846 63.5119 16.6125 138.022 126.231 167.766 193.112 75 3.5391 59.397 132.518 25.1922 22.2671 52.9824 39.5927 33.4476 64.6076 151.691 121.793 178.326 42.3611 68.7615 91.5788 73.9043 42.5005 109.146 78.8882 107.017 29.2054 96.7979 182.236 89.8398 143.4 87.4064 108.589 184.04 115.713 173.851 59.3442 142.655 164.865 63.7732 98.4493 328.682 195.483 4.26074 41.2563 49.3503 86.8095 65.797 88.1764
122.101 341.27 45.8271 111.864 96.4856 216.407 475.996 166.544 102.54 122.087 566.195 88.5815 101.498 23.6615 112.767 83.0292 285.801 218.695 74.51 0.0364659 104.856 245.159 65.3519 74.2908 89.3398 27.1809 58.4554 97.568 195.772 119.017 658.491 116.174 358.455 92.4325 58.2633 99.5997 148.97 94.7431 163.039 51.6364 131.694 118.301 181.225 304.889 127.31 219.24 214.37 219.041 267.803 56.7705 334.339 115.607 218.402 180.848 99.5617 137.092 12.0942 132.331 96.7552 106.283 206.252 161.969
0.88 0.87 0.87 0.87 0.87 0.87 0.87 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.85 0.85 0.85 0.85 0.85 0.85 0.85 0.85 0.85 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.83 0.83 0.83 0.83 0.83 0.83 0.82 0.82 0.82 0.82 0.82 0.82 0.82 0.82 0.82 0.81 0.81 0.81 0.80 0.80 0.80 0.80 0.79 0.79 0.78 0.78 0.78 0.78 0.77
2.83 1.36 0.83 1.11 0.94 0.92 2.52 1.37 1.13 0.36 4.69 0.75 1.22 0.12 0.88 0.97 1.21 1.31 0.62 0.04 0.44 1.40 0.58 0.52 0.48 0.55 0.79 0.92 1.18 0.87 3.55 1.12 0.87 1.14 0.58 0.30 0.91 0.64 1.28 0.55 0.81 0.97 0.82 1.43 0.97 1.36 0.82 1.50 1.02 0.75 1.88 0.62 1.59 1.25 1.23 0.94 0.12 1.10 0.59 1.01 1.04 1.16
ACCEPTED MANUSCRIPT
131.45 89.9409 282.067 73.7895 107.562 125.468 84.7939 284.219 84.7119 30.5878 69.2599 141.97 141.286 150.019 97.689 179.313 196.741 129.898 73.7723 83.461 79.7378 165.571 62.6403 640.215 0.0301103 29.7645 23.5214 13.6813 11.3419 125.978 29.569 26.0266 23.0133 17.9483 0 35.1574 93.8874 36.1027 35.923 29.9235 44.3761 115.026 45.7586 34.5581 24.1747 37.4457 65.5619 99.7439 43.9192 16.2747 26.1767 55.7425 17.2413 24.2936 2.28585 41.2517 31.9912 214.548 45.5067 34.9158 32.4318 29.5762
92.4211 69.3482 195.412 54.3571 68.2731 102.225 55.2438 130.907 64.4414 27.0592 54.428 75.8016 57.5279 131.092 51.7719 96.7976 148.147 119.292 44.155 62.626 63.2446 103.293 77.5058 253.345 0 39.1433 99.1109 37.014 42.6832 134.171 94.5174 36.6594 22.7613 52.1139 5.09622 98.7117 155.14 90.1237 74.6393 66.5068 48.6572 202.823 19.5552 76.3119 58.8744 93.0361 141.681 173.717 95.9453 43.992 63.8334 111.749 33.8477 45.7741 4.32644 71.7126 62.2655 408.834 90.3249 71.7792 28.5397 52.1664
RI PT
117.72 74.7987 325.822 73.9886 118.935 135.811 78.8548 261.667 91.2099 40.2352 64.7035 198.328 41.4485 176.444 92.3124 142.762 214.132 158.486 27.6734 114.792 86.798 178.24 165.69 5.49481 0.00111583 18.8251 26.7618 10.0858 15.4114 54.3439 32.6507 22.5881 17.7934 18.2058 3.26424 42.304 73.2065 41.5263 35.2154 36.5867 14.477 98.3206 13.4801 51.5303 30.5753 47.9351 72.3372 71.7487 52.4128 21.4157 39.8268 64.292 17.712 24.1193 3.50443 33.5113 42.5499 237.326 45.1808 48.8126 16.2705 28.5302
SC
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
TE D
Tspan14 Setx Naa20 Cdk6 Tia1 Ubtf Hspd1 Evpl Cwc22 Pawr Mcm5 Mrps17 Ndufa3 Rab32 Acbd4 Zwilch Mrps16 Gclm Enpp2 Tdrd7 Eif4e3 Prim1 Tm7sf2 Hmgcr Ndufa6 Cd164 Antxr1 Farp1 Pnpla6 Gbp9 Cebpzos Ift81 Tmco3 Ppp1r3d Rbpms2 Nup188 Rcn3 Zmynd8 H2afy Rfc3 Mxra7 Ccdc167 Cacnb3 Chmp6 Dcn
RDH12_MOUSE Retinol dehydrogenase 12 BL1S6_MOUSE Biogenesis of lysosome-related organelles complex 1 subunit 6 COA7_MOUSE Cytochrome c oxidase assembly factor 7 HINT3_MOUSE Histidine triad nucleotide-binding protein 3 GLTP_MOUSE Glycolipid transfer protein GPX1_MOUSE Glutathione peroxidase 1 RBX1_MOUSE E3 ubiquitin-protein ligase RBX1 KISHA_MOUSE Protein kish-A ITPK1_MOUSE Inositol-tetrakisphosphate 1-kinase TRIPC_MOUSE E3 ubiquitin-protein ligase TRIP12 ZKSC3_MOUSE Zinc finger protein with KRAB and SCAN domains 3 NDUAB_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 XPO5_MOUSE Exportin-5 SPS2_MOUSE Selenide, water dikinase 2 JAGN1_MOUSE Protein jagunal homolog 1 TFEB_MOUSE Transcription factor EB CB076_MOUSE UPF0538 protein C2orf76 homolog TSN14_MOUSE Tetraspanin-14 SETX_MOUSE Probable helicase senataxin NAA20_MOUSE N-alpha-acetyltransferase 20 CDK6_MOUSE Cyclin-dependent kinase 6 TIA1_MOUSE Nucleolysin TIA-1 UBF1_MOUSE Nucleolar transcription factor 1 D3Z7J9_MOUSE 60 kDa heat shock protein, mitochondrial (Fragment) EVPL_MOUSE Envoplakin CWC22_MOUSE Pre-mRNA-splicing factor CWC22 homolog PAWR_MOUSE PRKC apoptosis WT1 regulator protein MCM5_MOUSE DNA replication licensing factor MCM5 RT17_MOUSE 28S ribosomal protein S17, mitochondrial NDUA3_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 RAB32_MOUSE Ras-related protein Rab-32 A2AHR2_MOUSE Protein Acbd4 H3BKB9_MOUSE Protein zwilch homolog (Fragment) RT16_MOUSE 28S ribosomal protein S16, mitochondrial GSH0_MOUSE Glutamate--cysteine ligase regulatory subunit ENPP2_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 TDRD7_MOUSE Tudor domain-containing protein 7 IF4E3_MOUSE Eukaryotic translation initiation factor 4E type 3 PRI1_MOUSE DNA primase small subunit ERG24_MOUSE Delta(14)-sterol reductase HMDH_MOUSE 3-hydroxy-3-methylglutaryl-coenzyme A reductase NDUA6_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 MUC24_MOUSE Sialomucin core protein 24 ANTR1_MOUSE Anthrax toxin receptor 1 FARP1_MOUSE FERM, RhoGEF and pleckstrin domain-containing protein 1 PLPL6_MOUSE Neuropathy target esterase Q8BTS3_MOUSE Guanylate-binding protein 9 Q8BTE5_MOUSE Uncharacterized protein IFT81_MOUSE Intraflagellar transport protein 81 homolog TMCO3_MOUSE Transmembrane and coiled-coil domain-containing protein 3 A2AJW4_MOUSE Protein phosphatase 1 regulatory subunit 3 RBPS2_MOUSE RNA-binding protein with multiple splicing 2 NU188_MOUSE Nucleoporin NUP188 homolog RCN3_MOUSE Reticulocalbin-3 A2A482_MOUSE Protein Zmynd8 H2AY_MOUSE Core histone macro-H2A.1 RFC3_MOUSE Replication factor C subunit 3 MXRA7_MOUSE Matrix-remodeling-associated protein 7 CC167_MOUSE Coiled-coil domain-containing protein 167 CACB3_MOUSE Voltage-dependent L-type calcium channel subunit beta-3 CHMP6_MOUSE Charged multivesicular body protein 6 PGS2_MOUSE Decorin
EP
Rdh12 Bloc1s6 Coa7 Hint3 Gltp Gpx1 Rbx1 Tmem167a Itpk1 Trip12 Zkscan3 Ndufa11 Xpo5 Sephs2 Jagn1 Tfeb
AC C
sp|Q8BYK4|RDH12_MOUSE sp|Q9R0C0|BL1S6_MOUSE sp|Q921H9|COA7_MOUSE sp|Q9CPS6|HINT3_MOUSE sp|Q9JL62|GLTP_MOUSE sp|P11352|GPX1_MOUSE sp|P62878|RBX1_MOUSE sp|Q9CR64|KISHA_MOUSE sp|Q8BYN3|ITPK1_MOUSE sp|G5E870|TRIPC_MOUSE sp|Q91VW9|ZKSC3_MOUSE sp|Q9D8B4|NDUAB_MOUSE sp|Q924C1|XPO5_MOUSE sp|P97364|SPS2_MOUSE sp|Q5XKN4|JAGN1_MOUSE sp|Q9R210|TFEB_MOUSE sp|Q9CRW3|CB076_MOUSE sp|Q8QZY6|TSN14_MOUSE sp|A2AKX3|SETX_MOUSE sp|P61600|NAA20_MOUSE sp|Q64261|CDK6_MOUSE sp|P52912|TIA1_MOUSE sp|P25976|UBF1_MOUSE tr|D3Z7J9|D3Z7J9_MOUSE sp|Q9D952|EVPL_MOUSE sp|Q8C5N3|CWC22_MOUSE sp|Q925B0|PAWR_MOUSE sp|P49718|MCM5_MOUSE sp|Q9CQE3|RT17_MOUSE sp|Q9CQ91|NDUA3_MOUSE sp|Q9CZE3|RAB32_MOUSE tr|A2AHR2|A2AHR2_MOUSE tr|H3BKB9|H3BKB9_MOUSE sp|Q9CPX7|RT16_MOUSE sp|O09172|GSH0_MOUSE sp|Q9R1E6|ENPP2_MOUSE sp|Q8K1H1|TDRD7_MOUSE sp|Q9DBB5|IF4E3_MOUSE sp|P20664|PRI1_MOUSE sp|Q71KT5|ERG24_MOUSE sp|Q01237|HMDH_MOUSE sp|Q9CQZ5|NDUA6_MOUSE sp|Q9R0L9|MUC24_MOUSE sp|Q9CZ52|ANTR1_MOUSE sp|F8VPU2|FARP1_MOUSE sp|Q3TRM4|PLPL6_MOUSE tr|Q8BTS3|Q8BTS3_MOUSE tr|Q8BTE5|Q8BTE5_MOUSE sp|O35594|IFT81_MOUSE sp|Q8BH01|TMCO3_MOUSE tr|A2AJW4|A2AJW4_MOUSE sp|Q8VC52|RBPS2_MOUSE sp|Q6ZQH8|NU188_MOUSE sp|Q8BH97|RCN3_MOUSE tr|A2A482|A2A482_MOUSE sp|Q9QZQ8|H2AY_MOUSE sp|Q8R323|RFC3_MOUSE sp|Q9CZH7|MXRA7_MOUSE sp|Q9D162|CC167_MOUSE sp|P54285|CACB3_MOUSE sp|P0C0A3|CHMP6_MOUSE sp|P28654|PGS2_MOUSE
99.1715 57.0487 270.685 58.1627 104.106 94.2375 67.3552 276.633 66.3436 25.2155 44.3976 175.056 76.2343 107.221 86.5976 137.519 149.039 87.053 27.0517 71.3006 48.0035 120.081 62.6655 3.49984 0 128.535 60.4929 29.259 25.6911 317.912 61.1778 81.414 75.6323 32.979 2.05626 70.3596 185.658 64.4045 61.5013 58.6339 61.8725 197.172 90.521 82.6964 37.8532 57.4864 100.14 124.7 70.1817 19.9259 47.8714 88.9016 24.198 33.6589 5.09198 49.6295 58.5909 320.639 55.7976 62.6087 49.4201 40.3516
91.9931 38.353 248.74 66.3951 102.719 96.0832 99.4374 245.283 243.59 139.815 30.4812 102.816 62.6704 124.839 105.962 71.5148 111.104 96.4897 265.895 80.6347 92.112 119.495 133.712 165.644 745.255 65.5117 32.5003 34.2205 155.502 186.368 37.7098 44.2244 8.20438 97.3569 80.9935 122.851 84.1561 104.386 55.4505 11.6944 27.1103 168.324 30.5312 29.0251 63.9576 0 74.2106 114.939 53.6873 30.774 30.6906 25.577 26.6523 12.3018 93.6433 57.8708 34.005 437.96 52.788 38.8746 3.22211 13.8015
41.9367 101.819 279.597 92.3632 104.111 191.901 148.655 302.531 288.8 174.465 64.5354 115.358 77.1645 155.505 109.968 244.247 201.978 128.043 179.559 78.5555 100.484 367.755 179.333 14.8887 394.174 39.8357 58.7929 14.9302 173.328 80.1252 29.9406 19.7906 8.52624 149.692 94.6887 93.4234 70.8702 86.6643 45.9156 7.10403 19.6973 120.793 29.5344 34.9443 69.2227 0.133135 55.5522 140.152 47.6378 38.1128 36.1973 99.6962 16.0157 24.7276 242.988 3.6732 57.2877 264.114 48.798 38.5035 10.0437 22.2092
0.77 0.77 0.77 0.76 0.76 0.75 0.75 0.75 0.74 0.74 0.74 0.74 0.73 0.73 0.73 0.73 0.72 0.72 0.70 0.68 0.67 0.65 0.61 0.40 0.00 3.45 3.17 2.79 2.56 2.51 2.50 2.43 2.41 2.35 2.19 2.18 2.04 1.99 1.91 1.88 1.88 1.87 1.86 1.85 1.77 1.76 1.75 1.74 1.72 1.70 1.69 1.67 1.66 1.64 1.63 1.62 1.62 1.61 1.61 1.61 1.60 1.59
0.54 0.85 0.87 1.07 0.91 1.10 1.52 1.00 3.03 4.44 0.71 0.64 0.77 0.86 1.14 0.98 0.76 0.78 4.39 0.80 1.16 1.42 1.37 0.28 36489.60 2.17 1.82 2.07 12.29 1.48 1.09 1.32 0.41 6.83 53.82 2.79 0.93 2.46 1.42 0.28 0.80 1.36 1.01 0.74 2.43 0.00 0.94 1.49 1.05 1.83 1.01 1.04 1.22 0.76 58.14 0.82 1.22 1.55 1.12 0.92 0.27 0.62
ACCEPTED MANUSCRIPT
TE D
71.8065 59.2919 23.3713 25.8693 54.2603 19.4172 20.0156 7.29683 11.8063 21.6719 25.1046 15.9172 28.4232 41.3256 37.3026 71.9384 42.5178 21.0323 52.5702 78.4119 58.8733 20.9306 62.7248 52.2815 33.9678 55.5955 27.634 75.3326 35.1442 22.433 29.2837 126.978 69.4294 57.8536 23.5762 21.3065 35.7026 46.6317 26.1241 19.3547 52.9509 76.5861 192.806 25.9028 13.3917 22.5769 56.505 6.49863 35.3786 37.5485 74.3065 62.7008 44.7095 24.7499 20.3625 42.3218 45.9751 43.9193 41.3909 21.8454 8.31637 27.7648
95.882 125.73 38.8704 46.574 110.9 32.3335 29.458 15.6694 22.3558 41.4085 43.4886 34.7937 44.8823 60.2097 45.1037 136.117 110.864 33.3056 117.749 138.528 73.1243 43.5009 143.239 96.3983 37.0552 83.8489 53.9825 112.515 48.0775 36.8526 51.0304 143.755 98.1658 69.0944 43.7249 38.014 68.4367 124.592 64.5893 36.2929 100.321 145.505 219.047 46.1022 24.6587 38.3643 109.879 17.0698 51.5651 69.6373 62.9348 91.1998 102.108 40.4629 33.4736 57.6745 61.2549 64.4421 66.33 34.3213 20.4313 47.4364
RI PT
61.789 71.485 27.281 25.4274 59.2853 18.3814 12.6749 12.8442 15.829 28.5405 29.0652 25.81 28.4256 42.0921 44.7793 83.3505 70.0436 21.5401 65.7758 81.7184 50.4745 28.569 79.9532 70.9821 20.0872 45.7972 35.6405 81.1257 32.1484 22.9679 32.7314 152.902 62.6094 45.468 27.6438 24.9138 50.8186 70.5259 47.8554 22.1019 50.3731 94.9248 131.656 27.0171 16.2599 26.7673 66.8451 14.2529 34.2415 42.3758 41.3313 68.9834 64.6661 29.2471 22.6481 36.0676 42.6237 38.7431 33.3561 25.9206 15.0726 34.5255
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
PHLA3_MOUSE Pleckstrin homology-like domain family A member 3 ABCD1_MOUSE ATP-binding cassette sub-family D member 1 HECD3_MOUSE E3 ubiquitin-protein ligase HECTD3 OCRL_MOUSE Inositol polyphosphate 5-phosphatase OCRL-1 PLPL2_MOUSE Patatin-like phospholipase domain-containing protein 2 BRX1_MOUSE Ribosome biogenesis protein BRX1 homolog CX7A2_MOUSE Cytochrome c oxidase subunit 7A2, mitochondrial DJC25_MOUSE DnaJ homolog subfamily C member 25 RRP1B_MOUSE Ribosomal RNA processing protein 1 homolog B FINC_MOUSE Fibronectin NIPBL_MOUSE Nipped-B-like protein DEN6A_MOUSE Protein DENND6A TBCEL_MOUSE Tubulin-specific chaperone cofactor E-like protein PWP2_MOUSE Periodic tryptophan protein 2 homolog EMC10_MOUSE ER membrane protein complex subunit 10 CD82_MOUSE CD82 antigen SRBP1_MOUSE Sterol regulatory element-binding protein 1 EPS8_MOUSE Epidermal growth factor receptor kinase substrate 8 GLMN_MOUSE Glomulin F2Z4A3_MOUSE Protein Fat1 GALT7_MOUSE N-acetylgalactosaminyltransferase 7 CLPT1_MOUSE Cleft lip and palate transmembrane protein 1 homolog EXOSX_MOUSE Exosome component 10 ATLA1_MOUSE Atlastin-1 RFNG_MOUSE Beta-1,3-N-acetylglucosaminyltransferase radical fringe CIR1A_MOUSE Cirhin MFTC_MOUSE Mitochondrial folate transporter/carrier TMM43_MOUSE Transmembrane protein 43 E9Q238_MOUSE Protein Kank1 TMUB2_MOUSE Transmembrane and ubiquitin-like domain-containing protein 2 SYPM_MOUSE Probable proline--tRNA ligase, mitochondrial PXMP2_MOUSE Peroxisomal membrane protein 2 E9Q7E2_MOUSE Protein Arid2 IREB2_MOUSE Iron-responsive element-binding protein 2 GRAM4_MOUSE GRAM domain-containing protein 4 EMC7_MOUSE ER membrane protein complex subunit 7 BST2_MOUSE Bone marrow stromal antigen 2 GBRAP_MOUSE Gamma-aminobutyric acid receptor-associated protein ASAH2_MOUSE Neutral ceramidase STPAP_MOUSE Speckle targeted PIP5K1A-regulated poly(A) polymerase BTG1_MOUSE Protein BTG1 SP2_MOUSE Transcription factor Sp2 NDUB4_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 AUP1_MOUSE Ancient ubiquitous protein 1 SGCB_MOUSE Beta-sarcoglycan APOE_MOUSE Apolipoprotein E DIP2B_MOUSE Disco-interacting protein 2 homolog B ARAP1_MOUSE Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 PLRG1_MOUSE Pleiotropic regulator 1 MTER1_MOUSE mTERF domain-containing protein 1, mitochondrial OSMR_MOUSE Oncostatin-M-specific receptor subunit beta ASPN_MOUSE Asporin NID2_MOUSE Nidogen-2 PBIP1_MOUSE Pre-B-cell leukemia transcription factor-interacting protein 1 BIG1_MOUSE Brefeldin A-inhibited guanine nucleotide-exchange protein 1 VPP2_MOUSE V-type proton ATPase 116 kDa subunit a isoform 2 A2AUP1_MOUSE Protein Pfkfb3 E9Q453_MOUSE Tropomyosin alpha-1 chain Q3U821_MOUSE Protein Wdr75 Q3TMP1_MOUSE General transcription factor IIIC, polypeptide 3 AQP1_MOUSE Aquaporin-1 R3GEF_MOUSE Guanine nucleotide exchange factor for Rab-3A
EP
Phlda3 Abcd1 Hectd3 Ocrl Pnpla2 Brix1 Cox7a2 Dnajc25 Rrp1b Fn1 Nipbl Dennd6a Tbcel Pwp2 Emc10 Cd82 Srebf1 Eps8 Glmn Fat1 Galnt7 Clptm1 Exosc10 Atl1 Rfng Cirh1a Slc25a32 Tmem43 Kank1 Tmub2 Pars2 Pxmp2 Arid2 Ireb2 Gramd4 Emc7 Bst2 Gabarap Asah2 Tut1 Btg1 Sp2 Ndufb4 Aup1 Sgcb Apoe Dip2b Arap1 Plrg1 Mterfd1 Osmr Aspn Nid2 Pbxip1 Arfgef1 Atp6v0a2 Pfkfb3 Tpm1 Wdr75 Gtf3c3 Aqp1 Rab3il1
AC C
sp|Q9WV95|PHLA3_MOUSE sp|P48410|ABCD1_MOUSE sp|Q3U487|HECD3_MOUSE sp|Q6NVF0|OCRL_MOUSE sp|Q8BJ56|PLPL2_MOUSE sp|Q9DCA5|BRX1_MOUSE sp|P48771|CX7A2_MOUSE sp|A2ALW5|DJC25_MOUSE sp|Q91YK2|RRP1B_MOUSE sp|P11276|FINC_MOUSE sp|Q6KCD5|NIPBL_MOUSE sp|Q8BH65|DEN6A_MOUSE sp|Q8C5W3|TBCEL_MOUSE sp|Q8BU03|PWP2_MOUSE sp|Q3TAS6|EMC10_MOUSE sp|P40237|CD82_MOUSE sp|Q9WTN3|SRBP1_MOUSE sp|Q08509|EPS8_MOUSE sp|Q8BZM1|GLMN_MOUSE tr|F2Z4A3|F2Z4A3_MOUSE sp|Q80VA0|GALT7_MOUSE sp|Q8VBZ3|CLPT1_MOUSE sp|P56960|EXOSX_MOUSE sp|Q8BH66|ATLA1_MOUSE sp|O09009|RFNG_MOUSE sp|Q8R2N2|CIR1A_MOUSE sp|Q8BMG8|MFTC_MOUSE sp|Q9DBS1|TMM43_MOUSE tr|E9Q238|E9Q238_MOUSE sp|Q3V209|TMUB2_MOUSE sp|Q8CFI5|SYPM_MOUSE sp|P42925|PXMP2_MOUSE tr|E9Q7E2|E9Q7E2_MOUSE sp|Q811J3|IREB2_MOUSE sp|Q8CB44|GRAM4_MOUSE sp|Q9EP72|EMC7_MOUSE sp|Q8R2Q8|BST2_MOUSE sp|Q9DCD6|GBRAP_MOUSE sp|Q9JHE3|ASAH2_MOUSE sp|Q8R3F9|STPAP_MOUSE sp|P62325|BTG1_MOUSE sp|Q9D2H6|SP2_MOUSE sp|Q9CQC7|NDUB4_MOUSE sp|P70295|AUP1_MOUSE sp|P82349|SGCB_MOUSE sp|P08226|APOE_MOUSE sp|Q3UH60|DIP2B_MOUSE sp|Q4LDD4|ARAP1_MOUSE sp|Q922V4|PLRG1_MOUSE sp|Q8R3J4|MTER1_MOUSE sp|O70458|OSMR_MOUSE sp|Q99MQ4|ASPN_MOUSE sp|O88322|NID2_MOUSE sp|Q3TVI8|PBIP1_MOUSE sp|G3X9K3|BIG1_MOUSE sp|P15920|VPP2_MOUSE tr|A2AUP1|A2AUP1_MOUSE tr|E9Q453|E9Q453_MOUSE tr|Q3U821|Q3U821_MOUSE tr|Q3TMP1|Q3TMP1_MOUSE sp|Q02013|AQP1_MOUSE sp|Q8VDV3|R3GEF_MOUSE
115.705 81.3579 40.5965 33.4457 65.8704 26.2929 21.1937 15.2344 20.0029 35.4848 39.3336 28.6263 41.1408 65.4379 78.3756 97.2762 58.1488 30.5933 58.8828 100.371 89.1359 29.7807 67.6877 85.4044 42.5653 64.9491 38.8193 116.7 50.0152 29.114 38.687 260.509 92.5226 79.8136 30.0107 28.4953 55.6418 43.3313 41.3236 23 47.383 99.201 243.114 28.7231 17.2341 31.1713 63.7378 12.0624 45.9654 42.2833 98.7245 92.6697 50.3559 34.7925 26.3497 51.1876 61.6384 50.1884 37.3142 31.9084 11.9964 38.8902
71.8767 509.171 27.6624 62.1167 41.2858 227.572 27.5775 21.5335 21.0448 19.4257 57.768 20.4346 40.6812 53.7733 28.0506 98.2699 25.002 54.7796 86.1082 79.0461 75.8217 15.6811 75.5498 53.4454 47.3676 51.6413 72.0093 114.724 43.0473 20.7321 19.6921 41.6802 105.422 114.485 39.4394 27.9239 37.3911 50.9929 22.5059 28.5949 63.1307 126.322 262.504 28.1669 17.9029 10.9246 87.3295 72.9205 44.6961 16.8361 54.3465 31.0777 47.3919 24.4397 32.4411 90.7763 46.2792 60.7604 40.6274 29.3844 107.757 24.8903
108.378 238.274 34.25 140.192 124.775 71.2186 17.1582 49.18 27.2716 27.5219 149.391 11.3076 69.8406 33.1148 24.5238 49.0457 3.45789 74.5775 38.5991 71.1122 47.8602 19.8737 50.9546 52.6983 51.2915 51.7157 48.956 91.3174 89.2566 8.73704 19.3186 75.7718 104.034 78.9068 60.024 16.5116 48.4495 41.4881 16.1442 40.9882 59.7197 89.3309 158.792 33.4017 0 19.3465 79.5916 31.9226 123.302 40.8051 76.6894 56.5231 36.8813 37.2971 22.071 42.7715 45.3392 106.564 30.1937 42.1305 55.632 27.8741
1.58 1.58 1.57 1.56 1.56 1.55 1.55 1.53 1.53 1.53 1.53 1.52 1.51 1.51 1.50 1.50 1.50 1.50 1.49 1.49 1.48 1.48 1.48 1.47 1.47 1.47 1.47 1.47 1.46 1.45 1.45 1.44 1.44 1.44 1.44 1.44 1.43 1.43 1.43 1.43 1.43 1.43 1.42 1.41 1.41 1.41 1.41 1.40 1.40 1.40 1.40 1.40 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39
1.35 5.72 1.22 3.94 1.46 7.90 1.37 3.51 1.75 0.93 3.82 0.76 1.94 1.04 0.64 0.95 0.25 3.04 1.05 0.94 1.13 0.72 0.89 0.86 1.83 1.02 1.91 1.32 1.97 0.65 0.63 0.42 1.59 1.87 1.94 0.96 0.99 0.79 0.52 1.68 1.19 1.26 1.30 1.16 0.60 0.61 1.35 5.05 2.41 0.72 1.13 0.67 0.77 1.14 1.27 1.70 1.03 2.02 0.95 1.50 6.99 0.85
ACCEPTED MANUSCRIPT
TE D
62.6884 41.4462 29.5109 78.9732 51.6882 30.5562 38.5691 33.5183 19.9427 74.4493 81.7059 36.0043 44.8574 47.6372 78.8928 17.9911 16.518 42.8252 12.561 17.4403 19.9874 64.6701 41.1283 17.2417 31.4557 55.3031 45.0012 47.6083 93.1727 21.8804 54.8067 66.4396 53.876 184.394 32.3967 39.8797 54.646 120.872 33.9997 41.8991 25.9143 48.6312 62.6096 16.7834 51.1531 78.9449 30.2285 31.7151 46.6111 31.0024 30.5442 78.3008 53.5675 45.9561 29.1294 71.6084 47.408 45.738 20.8164 43.409 78.3036 12.7442
99.3905 71.8609 27.3221 137.976 73.9055 41.2062 61.7313 48.6148 42.0533 95.3269 145.733 65.8741 77.0639 63.3374 133.856 40.0928 29.6622 48.0495 26.3821 23.3281 28.6602 96.8791 66.4266 20.4899 32.589 76.2494 59.9517 61.1255 136.763 34.9133 90.6244 107.088 121.205 333.659 47.5975 71.8058 94.709 206.473 44.5471 62.3178 38.6013 69.6978 85.476 28.7039 77.0154 84.7951 45.9131 34.5697 58.3845 42.9084 43.9105 59.2373 83.9552 64.0851 34.1643 99.6123 57.9458 63.1495 19.8484 66.021 120.614 19.2892
RI PT
54.9932 53.6831 20.9853 85.6937 49.2246 23.7078 45.5654 27.28 31.2349 60.3497 99.7443 48.0005 60.8148 44.6861 86.8866 25.9416 19.0309 22.7255 20.382 17.3959 20.5615 66.1889 46.5824 17.9184 17.3294 53.8116 44.6466 38.9324 89.0959 20.2358 53.4917 78.2165 89.7302 204.388 34.0587 45.7467 59.2878 151.586 34.661 42.0802 30.2297 51.2809 60.607 20.5007 63.7861 64.8837 27.2513 21.521 45.9724 28.358 35.3769 43.678 67.9637 42.7971 27.3698 65.6123 45.9977 45.3611 15.8915 44.9211 64.7169 14.3318
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
PT117_MOUSE Protein PET117 homolog, mitochondrial PYRG1_MOUSE CTP synthase 1 CBX4_MOUSE E3 SUMO-protein ligase CBX4 SEC20_MOUSE Vesicle transport protein SEC20 ZCCHV_MOUSE Zinc finger CCCH-type antiviral protein 1 IMP1L_MOUSE Mitochondrial inner membrane protease subunit 1 NSUN6_MOUSE Putative methyltransferase NSUN6 COX16_MOUSE Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial BRD9_MOUSE Bromodomain-containing protein 9 JCAD_MOUSE Junctional protein associated with coronary artery disease EPG5_MOUSE Ectopic P granules protein 5 homolog MOR2A_MOUSE MORC family CW-type zinc finger protein 2A TM205_MOUSE Transmembrane protein 205 MKRN2_MOUSE Probable E3 ubiquitin-protein ligase makorin-2 DUS3L_MOUSE tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like UVSSA_MOUSE UV-stimulated scaffold protein A DOP1_MOUSE Protein dopey-1 TOM34_MOUSE Mitochondrial import receptor subunit TOM34 GLYC_MOUSE Serine hydroxymethyltransferase, cytosolic PKHG3_MOUSE Pleckstrin homology domain-containing family G member 3 CD44_MOUSE CD44 antigen RBPMS_MOUSE RNA-binding protein with multiple splicing ALG12_MOUSE Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase TMED1_MOUSE Transmembrane emp24 domain-containing protein 1 PKHA6_MOUSE Pleckstrin homology domain-containing family A member 6 NVL_MOUSE Nuclear valosin-containing protein-like RM23_MOUSE 39S ribosomal protein L23, mitochondrial A4_MOUSE Amyloid beta A4 protein SOS1_MOUSE Son of sevenless homolog 1 RIN2_MOUSE Ras and Rab interactor 2 TBC31_MOUSE TBC1 domain family member 31 WLS_MOUSE Protein wntless homolog PI42A_MOUSE Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha NMNA1_MOUSE Nicotinamide mononucleotide adenylyltransferase 1 NPA1P_MOUSE Nucleolar pre-ribosomal-associated protein 1 C560_MOUSE Succinate dehydrogenase cytochrome b560 subunit, mitochondrial CTL2_MOUSE Choline transporter-like protein 2 SLIT3_MOUSE Slit homolog 3 protein METL9_MOUSE Methyltransferase-like protein 9 CMKMT_MOUSE Calmodulin-lysine N-methyltransferase B1ART1_MOUSE Protein Vps13d TBL3_MOUSE Transducin beta-like protein 3 SPD2B_MOUSE SH3 and PX domain-containing protein 2B E9PVS5_MOUSE Mitochondrial inner membrane protein (Fragment) E0CXD7_MOUSE LIM domain only protein 3 UTP6_MOUSE U3 small nucleolar RNA-associated protein 6 homolog MFAP3_MOUSE Microfibril-associated glycoprotein 3 NSMA3_MOUSE Sphingomyelin phosphodiesterase 4 RFA1_MOUSE Replication protein A 70 kDa DNA-binding subunit ZFY16_MOUSE Zinc finger FYVE domain-containing protein 16 NUDT6_MOUSE Nucleoside diphosphate-linked moiety X motif 6 TBCC_MOUSE Tubulin-specific chaperone C IL6RB_MOUSE Interleukin-6 receptor subunit beta CASP7_MOUSE Caspase-7 KC1D_MOUSE Casein kinase I isoform delta HPS5_MOUSE Hermansky-Pudlak syndrome 5 protein homolog Q7TNL7_MOUSE Dual specificity protein phosphatase MYO19_MOUSE Unconventional myosin-XIX OTUL_MOUSE Ubiquitin thioesterase otulin MCE1_MOUSE mRNA-capping enzyme ALKB3_MOUSE Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 CCNK_MOUSE Cyclin-K
EP
Pet117 Ctps1 Cbx4 Bnip1 Zc3hav1 Immp1l Nsun6 Cox16 Brd9 Jcad Epg5 Morc2a Tmem205 Mkrn2 Dus3l Uvssa Dopey1 Tomm34 Shmt1 Plekhg3 Cd44 Rbpms Alg12 Tmed1 Plekha6 Nvl Mrpl23 App Sos1 Rin2 Tbc1d31 Wls Pip4k2a Nmnat1 Urb1 Sdhc Slc44a2 Slit3 Mettl9 Camkmt Vps13d Tbl3 Sh3pxd2b Immt Lmo3 Utp6 Mfap3 Smpd4 Rpa1 Zfyve16 Nudt6 Tbcc Il6st Casp7 Csnk1d Hps5 Dusp9 Myo19 Otulin Rngtt Alkbh3 Ccnk
AC C
sp|P0DJF2|PT117_MOUSE sp|P70698|PYRG1_MOUSE sp|O55187|CBX4_MOUSE sp|Q6QD59|SEC20_MOUSE sp|Q3UPF5|ZCCHV_MOUSE sp|Q9CQU8|IMP1L_MOUSE sp|Q7TS68|NSUN6_MOUSE sp|Q9CR63|COX16_MOUSE sp|Q3UQU0|BRD9_MOUSE sp|Q5DTX6|JCAD_MOUSE sp|Q80TA9|EPG5_MOUSE sp|Q69ZX6|MOR2A_MOUSE sp|Q91XE8|TM205_MOUSE sp|Q9ERV1|MKRN2_MOUSE sp|Q91XI1|DUS3L_MOUSE sp|Q9D479|UVSSA_MOUSE sp|Q8BL99|DOP1_MOUSE sp|Q9CYG7|TOM34_MOUSE sp|P50431|GLYC_MOUSE sp|Q4VAC9|PKHG3_MOUSE sp|P15379|CD44_MOUSE sp|Q9WVB0|RBPMS_MOUSE sp|Q8VDB2|ALG12_MOUSE sp|Q3V009|TMED1_MOUSE sp|Q7TQG1|PKHA6_MOUSE sp|Q9DBY8|NVL_MOUSE sp|O35972|RM23_MOUSE sp|P12023|A4_MOUSE sp|Q62245|SOS1_MOUSE sp|Q9D684|RIN2_MOUSE sp|Q6NXY1|TBC31_MOUSE sp|Q6DID7|WLS_MOUSE sp|O70172|PI42A_MOUSE sp|Q9EPA7|NMNA1_MOUSE sp|Q571H0|NPA1P_MOUSE sp|Q9CZB0|C560_MOUSE sp|Q8BY89|CTL2_MOUSE sp|Q9WVB4|SLIT3_MOUSE sp|Q9EPL4|METL9_MOUSE sp|Q3U2J5|CMKMT_MOUSE tr|B1ART1|B1ART1_MOUSE sp|Q8C4J7|TBL3_MOUSE sp|A2AAY5|SPD2B_MOUSE tr|E9PVS5|E9PVS5_MOUSE tr|E0CXD7|E0CXD7_MOUSE sp|Q8VCY6|UTP6_MOUSE sp|Q922T2|MFAP3_MOUSE sp|Q6ZPR5|NSMA3_MOUSE sp|Q8VEE4|RFA1_MOUSE sp|Q80U44|ZFY16_MOUSE sp|Q8CH40|NUDT6_MOUSE sp|Q8VCN9|TBCC_MOUSE sp|Q00560|IL6RB_MOUSE sp|P97864|CASP7_MOUSE sp|Q9DC28|KC1D_MOUSE sp|P59438|HPS5_MOUSE tr|Q7TNL7|Q7TNL7_MOUSE sp|Q5SV80|MYO19_MOUSE sp|Q3UCV8|OTUL_MOUSE sp|O55236|MCE1_MOUSE sp|Q8K1E6|ALKB3_MOUSE sp|O88874|CCNK_MOUSE
63.4414 59.4885 42.0735 88.2919 64.7424 33.2987 53.6048 34.668 27.7452 88.4837 101.559 48.4903 66.7272 62.2145 91.441 19.505 18.5444 40.5184 18.0627 23.6662 26.001 78.9892 51.4444 26.753 32.9496 70.1725 60.3304 54.9086 107.6 21.5462 54.0879 86.0865 70.4391 184.466 40.897 42.1919 56.8911 155.862 46.4415 48.9391 35.7536 62.2822 77.2266 20.5257 74.5012 104.58 29.6443 35.2874 63.0059 34.9144 42.4872 100.11 74.372 51.5129 39.386 78.8681 63.4418 55.0816 27.7711 48.5266 64.0264 15.6648
80.8075 64.0357 40.3503 110.175 80.5899 32.2079 73.6209 76.9692 80.057 78.1981 44.0652 46.1238 41.5821 27.3016 64.8198 20.649 22.078 74.495 24.5064 29.3867 39.2905 69.9923 61.4872 16.1108 17.5699 146.405 20.2349 56.0129 121.362 27.88 47.5557 88.1802 66.7684 114.794 87.6902 93.0964 90.0583 147.938 42.0256 57.7288 41.0608 77.2082 75.5968 34.8844 53.2858 83.7882 16.07 42.3968 78.533 39.252 6.62595 116.915 62.6542 68.3451 16.6765 68.1512 88.1082 67.7606 25.0232 76.1233 47.4429 24.0793
88.0532 51.0856 74.469 109.791 115.343 33.7578 177.898 117.18 70.8485 170.826 62.6812 94.6167 40.2934 83.0752 108.925 19.6374 20.9138 59.2605 6.40095 71.4762 37.6438 161.051 48.9042 9.9645 53.6665 155.35 48.1389 90.6179 84.8851 32.4289 157.901 64.8076 55.4991 192.871 58.3794 158.635 35.1146 111.971 28.6308 30.3745 33.4894 44.4715 68.9982 24.9328 77.3296 28.7508 18.5534 28.0525 57.2073 42.3271 14.1394 161.898 64.3745 94.5652 24.0419 83.7043 97.8373 71.2119 19.769 111.334 115.053 15.506
1.38 1.38 1.37 1.37 1.37 1.37 1.37 1.37 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.35 1.35 1.35 1.35 1.34 1.34 1.34 1.34 1.34 1.34 1.34 1.34 1.34 1.34 1.34 1.33 1.33 1.33 1.33 1.33 1.33 1.33 1.32 1.32 1.32 1.32 1.32 1.32 1.32 1.31 1.31 1.31 1.31 1.31 1.31 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.30 1.29 1.29
1.43 1.21 2.27 1.34 1.94 1.22 2.99 3.19 2.95 1.85 0.59 1.68 0.77 1.20 1.05 0.92 1.21 2.04 0.94 2.90 1.90 1.77 1.26 0.74 1.46 2.77 0.76 1.69 1.13 1.43 1.90 1.06 0.85 0.79 2.20 2.94 1.10 0.95 1.03 1.05 1.33 1.22 1.17 1.60 1.14 0.78 0.60 1.32 1.47 1.37 0.32 2.29 1.05 1.84 0.72 1.11 1.99 1.53 1.22 2.12 1.14 1.46
ACCEPTED MANUSCRIPT
22.3647 82.6705 23.7128 36.1303 64.2988 41.3306 119.272 45.441 48.1217 68.5997 23.2861 39.79 238.97 21.5632 60.3258 60.0526 92.8762 50.346 153.098 36.7495 35.3375 40.2524 62.6897 24.1866 36.788 33.2211 54.8027 50.8117 16.6965 62.0099 38.5446 18.2095 73.1059 43.2757 78.1162 32.4643 13.6306 19.5176 48.7595 44.3712 66.3807 23.2843 16.4033 76.8232 35.2154 26.1193 64.5016 48.1357 81.5006 46.3468 33.9604 38.486 38.9763 35.8748 28.1733 22.4296 33.2555 46.0815 46.1631 106.648 17.972 50.4753
45.0955 80.9298 35.8949 53.3326 64.9862 45.5728 89.1517 56.9922 80.9949 82.2745 33.3193 64.7651 299.916 22.7054 47.6463 91.8063 134.729 68.1227 201.506 54.2156 64.9025 67.85 111.264 40.2973 50.6189 40.3424 72.0196 81.4691 23.1546 93.0019 64.5881 21.0291 102.835 36.2111 101.419 76.4396 15.3543 29.6553 50.9948 64.7123 38.7564 35.949 26.4714 87.3509 46.5419 31.5021 99.4129 74.4527 102.871 77.311 44.3302 44.8195 52.1727 62.3558 37.4366 22.1407 45.9637 69.2935 60.898 146.57 28.6079 69.8111
RI PT
31.1488 51.5546 25.2496 37.4752 37.6456 37.813 77.7389 38.4819 60.6425 52.5766 24.3306 48.1056 231.917 16.7255 30.9429 74.8758 94.567 55.9074 145.305 36.818 47.3175 45.4701 84.7243 38.4018 35.0213 27.0427 49.4864 60.4777 12.4438 74.5732 48.5916 17.0109 76.4927 24.5994 78.3563 61.6942 11.8932 25.2352 39.2456 47.2898 39.3962 29.8042 19.9744 63.7708 34.5802 24.9476 70.7902 46.8717 72.1444 61.6676 30.1254 37.1728 37.0134 45.817 23.8879 19.2988 30.9534 55.5262 44.9519 110.466 26.9893 50.2909
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
TE D
Nol6 Jak1 Smg6 Polr2b Epdr1 Hat1 Micall2 Arhgef1 Man1a2 Mvk Cyth1 Tmem57 Zcchc6 Arih2 Fbxo22 Stk25 Mrps11 Zcrb1 Gtf2h1 Ndc1 Mrpl13 Slc35b3 Itfg3 Mb Dhx57 Tnfrsf1a Pnpla7 Kdm5c Gsk3a Tpm2 Htt Tmem199 Thoc7 Fam173b Nrbp2 Morf4l2 Sirt2 Abl1 Map4k5 Narfl Oxt Mob2 Bmi1 Fam65a Map4k3 Tmppe Nelfcd Rab6b Dimt1 Sptan1 Mtmr6 Cers4 Phf2 Sumo1
UBP30_MOUSE Ubiquitin carboxyl-terminal hydrolase 30 ABHDB_MOUSE Alpha/beta hydrolase domain-containing protein 11 PA2G5_MOUSE Calcium-dependent phospholipase A2 ADCK5_MOUSE Uncharacterized aarF domain-containing protein kinase 5 PLCH2_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 ELOV1_MOUSE Elongation of very long chain fatty acids protein 1 FHL3_MOUSE Four and a half LIM domains protein 3 CA198_MOUSE Uncharacterized protein C1orf198 homolog NOL6_MOUSE Nucleolar protein 6 JAK1_MOUSE Tyrosine-protein kinase JAK1 EST1A_MOUSE Telomerase-binding protein EST1A RPB2_MOUSE DNA-directed RNA polymerase II subunit RPB2 EPDR1_MOUSE Mammalian ependymin-related protein 1 HAT1_MOUSE Histone acetyltransferase type B catalytic subunit MILK2_MOUSE MICAL-like protein 2 ARHG1_MOUSE Rho guanine nucleotide exchange factor 1 MA1A2_MOUSE Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB KIME_MOUSE Mevalonate kinase CYH1_MOUSE Cytohesin-1 MACOI_MOUSE Macoilin TUT7_MOUSE Terminal uridylyltransferase 7 ARI2_MOUSE E3 ubiquitin-protein ligase ARIH2 FBX22_MOUSE F-box only protein 22 STK25_MOUSE Serine/threonine-protein kinase 25 RT11_MOUSE 28S ribosomal protein S11, mitochondrial ZCRB1_MOUSE Zinc finger CCHC-type and RNA-binding motif-containing protein 1 TF2H1_MOUSE General transcription factor IIH subunit 1 NDC1_MOUSE Nucleoporin NDC1 RM13_MOUSE 39S ribosomal protein L13, mitochondrial S35B3_MOUSE Adenosine 3'-phospho 5'-phosphosulfate transporter 2 ITFG3_MOUSE Protein ITFG3 MYG_MOUSE Myoglobin DHX57_MOUSE Putative ATP-dependent RNA helicase DHX57 TNR1A_MOUSE Tumor necrosis factor receptor superfamily member 1A PLPL7_MOUSE Patatin-like phospholipase domain-containing protein 7 KDM5C_MOUSE Lysine-specific demethylase 5C GSK3A_MOUSE Glycogen synthase kinase-3 alpha TPM2_MOUSE Isoform 2 of Tropomyosin beta chain HD_MOUSE Huntingtin TM199_MOUSE Transmembrane protein 199 THOC7_MOUSE THO complex subunit 7 homolog F173B_MOUSE Protein FAM173B NRBP2_MOUSE Nuclear receptor-binding protein 2 MO4L2_MOUSE Mortality factor 4-like protein 2 SIR2_MOUSE NAD-dependent protein deacetylase sirtuin-2 ABL1_MOUSE Tyrosine-protein kinase ABL1 M4K5_MOUSE Mitogen-activated protein kinase kinase kinase kinase 5 NARFL_MOUSE Cytosolic Fe-S cluster assembly factor NARFL NEU1_MOUSE Oxytocin-neurophysin 1 MOB2_MOUSE MOB kinase activator 2 BMI1_MOUSE Polycomb complex protein BMI-1 FA65A_MOUSE Protein FAM65A M4K3_MOUSE Mitogen-activated protein kinase kinase kinase kinase 3 D3Z286_MOUSE Protein Tmppe NELFD_MOUSE Negative elongation factor D RAB6B_MOUSE Ras-related protein Rab-6B DIM1_MOUSE Probable dimethyladenosine transferase SPTN1_MOUSE Isoform 2 of Spectrin alpha chain, non-erythrocytic 1 MTMR6_MOUSE Myotubularin-related protein 6 CERS4_MOUSE Ceramide synthase 4 PHF2_MOUSE Lysine-specific demethylase PHF2 SUMO1_MOUSE Small ubiquitin-related modifier 1
EP
Usp30 Abhd11 Pla2g5 Adck5 Plch2 Elovl1 Fhl3
AC C
sp|Q3UN04|UBP30_MOUSE sp|Q8K4F5|ABHDB_MOUSE sp|P97391|PA2G5_MOUSE sp|Q80V03|ADCK5_MOUSE sp|A2AP18|PLCH2_MOUSE sp|Q9JLJ5|ELOV1_MOUSE sp|Q9R059|FHL3_MOUSE sp|Q8C3W1|CA198_MOUSE sp|Q8R5K4|NOL6_MOUSE sp|P52332|JAK1_MOUSE sp|P61406|EST1A_MOUSE sp|Q8CFI7|RPB2_MOUSE sp|Q99M71|EPDR1_MOUSE sp|Q8BY71|HAT1_MOUSE sp|Q3TN34|MILK2_MOUSE sp|Q61210|ARHG1_MOUSE sp|P39098|MA1A2_MOUSE sp|Q9R008|KIME_MOUSE sp|Q9QX11|CYH1_MOUSE sp|Q7TQE6|MACOI_MOUSE sp|Q5BLK4|TUT7_MOUSE sp|Q9Z1K6|ARI2_MOUSE sp|Q78JE5|FBX22_MOUSE sp|Q9Z2W1|STK25_MOUSE sp|Q9DCA2|RT11_MOUSE sp|Q9CZ96|ZCRB1_MOUSE sp|Q9DBA9|TF2H1_MOUSE sp|Q8VCB1|NDC1_MOUSE sp|Q9D1P0|RM13_MOUSE sp|Q922Q5|S35B3_MOUSE sp|Q8C0Z1|ITFG3_MOUSE sp|P04247|MYG_MOUSE sp|Q6P5D3|DHX57_MOUSE sp|P25118|TNR1A_MOUSE sp|A2AJ88|PLPL7_MOUSE sp|P41230|KDM5C_MOUSE sp|Q2NL51|GSK3A_MOUSE sp|P58774-2|TPM2_MOUSE sp|P42859|HD_MOUSE sp|Q5SYH2|TM199_MOUSE sp|Q7TMY4|THOC7_MOUSE sp|Q9D1Z3|F173B_MOUSE sp|Q91V36|NRBP2_MOUSE sp|Q9R0Q4|MO4L2_MOUSE sp|Q8VDQ8|SIR2_MOUSE sp|P00520|ABL1_MOUSE sp|Q8BPM2|M4K5_MOUSE sp|Q7TMW6|NARFL_MOUSE sp|P35454|NEU1_MOUSE sp|Q8VI63|MOB2_MOUSE sp|P25916|BMI1_MOUSE sp|Q68FE6|FA65A_MOUSE sp|Q99JP0|M4K3_MOUSE tr|D3Z286|D3Z286_MOUSE sp|Q922L6|NELFD_MOUSE sp|P61294|RAB6B_MOUSE sp|Q9D0D4|DIM1_MOUSE sp|P16546-2|SPTN1_MOUSE sp|Q8VE11|MTMR6_MOUSE sp|Q9D6J1|CERS4_MOUSE sp|Q9WTU0|PHF2_MOUSE sp|P63166|SUMO1_MOUSE
23.9834 92.2151 27.2131 41.515 66.3755 56.1595 163.893 50.7425 58.5215 73.121 27.6233 47.7127 301.948 26.2325 68.9876 80.5346 104.496 67.3531 178.642 39.4988 40.3671 41.215 76.284 39.2733 40.6658 36.2043 60.28 59.5642 13.7502 79.8093 45.6409 23.52 86.3475 49.5821 96.0261 42.3567 16.8396 26.711 59.7738 50.5843 94.1267 30.6841 19.1858 89.0872 41.0318 32.4972 70.1317 44.6076 88.9792 57.4899 35.6466 49.5972 42.572 39.4847 27.4607 29.8584 34.0393 57.297 52.4999 123.526 27.2509 55.0122
40.7166 63.5491 0 75.0302 14.2283 37.641 27.9611 24.1826 55.2355 78.4052 21.4274 46.4608 123.616 29.5686 95.9178 81.287 76.4091 33.9057 118.887 31.1273 48.5508 61.8242 115.357 23.9936 19.442 24.6975 64.2004 79.0777 10.3324 20.2546 28.8776 94.0483 101.471 22.415 72.7287 43.07 24.9145 26.6892 75.6071 54.5492 48.4762 26.2913 34.9639 33.3357 44.9661 36.6184 80.4133 44.3252 70.7277 38.185 37.1885 35.034 41.6932 62.1335 36.8356 32.5455 60.0324 63.7705 57.1624 98.4375 37.0005 67.4173
24.9995 101.418 0.0534311 71.1607 75.8931 26.6458 36.1901 43.7673 67.0576 99.4637 49.1498 31.9484 163.516 20.8627 208.915 94.869 71.031 32.9656 139.738 58.0051 39.5432 56.3331 61.074 16.9497 32.7427 40.6103 67.1271 53.7859 19.6953 41.7812 16.8215 121.945 58.4716 61.16 67.3457 60.1059 41.4124 36.501 47.6653 48.3768 61.0259 52.6097 20.9012 27.0186 53.873 61.2794 66.0454 55.4985 86.5962 34.2968 53.4983 55.2739 45.9757 24.9456 30.8381 29.949 40.7488 71.8195 41.5091 117.631 49.5916 134.54
1.29 1.29 1.29 1.29 1.29 1.29 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.28 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.27 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.26 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.25 1.24 1.24 1.24 1.24
1.23 1.23 0.00 1.99 0.88 0.81 0.33 0.81 1.12 1.47 1.48 0.89 0.61 1.32 3.34 1.31 0.79 0.63 0.87 1.21 1.07 1.38 1.20 0.65 0.73 1.08 1.26 1.19 1.03 0.45 0.52 6.13 1.07 1.23 0.90 1.10 2.60 1.41 1.40 1.12 1.04 1.49 1.54 0.43 1.42 1.92 1.08 1.05 1.02 0.67 1.42 1.19 1.15 1.07 1.30 1.50 1.57 1.33 1.08 1.00 1.93 2.00
ACCEPTED MANUSCRIPT
46.2067 29.0395 20.2569 41.3268 94.0479 23.369 39.8278 135.354 68.143 20.604 32.3203 16.4022 50.9423 60.0608 44.6185 66.8646 31.632 53.5065 56.0271 93.4819 16.1681 59.0585 37.8405 64.0797 28.3583 105.406 63.7551 56.4524 48.4451 10.6396 76.4083 14.5718 41.7245 53.5678 29.0968 29.744 29.7747 46.9607 17.2825 23.1549 25.7048 27.5003 49.1669 32.5635 86.7899 29.7759 62.4414 54.2396 43.2704 55.9879 43.5909 24.8006 77.5551 67.64 103.047 48.9314 50.033 43.8624 71.0353 23.1998 47.6695 22.3402
61.4759 26.9683 24.8576 56.9347 120.18 32.6159 57.1452 207.583 104.812 32.7985 50.2686 30.0198 72.8825 93.6637 60.654 106.402 42.4628 66.2898 93.9069 121.16 19.437 43.6394 47.3888 69.0282 48.8822 92.2443 74.6257 85.2407 78.1619 17.8116 104.468 33.5286 54.4705 75.0721 39.4387 38.2881 48.3194 60.5015 28.1962 24.1955 39.0793 34.2977 74.8804 38.3093 106.104 42.308 71.8039 82.3577 65.9871 88.9442 32.1093 36.6494 92.19 85.2201 196.09 85.6222 70.9571 36.9255 90.2408 32.104 52.1144 30.5815
RI PT
47.938 20.7393 18.6501 52.7665 101.797 24.2095 46.6463 149.984 81.6161 21.3649 42.1075 20.0727 51.2021 66.9537 45.6946 81.6042 31.814 52.509 76.6398 92.5203 15.8837 34.1694 43.0582 60.3746 47.2251 85.6958 51.4695 58.4802 71.755 13.6776 73.0224 30.822 42.3887 53.8747 30.119 27.9516 44.2242 43.1645 25.0516 16.5656 26.9697 28.2829 49.7883 24.409 83.3609 36.4458 50.1617 60.8154 52.0933 70.5343 20.5021 31.2803 82.3566 69.4529 132.656 60.7703 54.7742 45.5793 71.3216 25.8579 31.2488 27.1131
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
TE D
INT6_MOUSE Integrator complex subunit 6 CTR1_MOUSE High affinity cationic amino acid transporter 1 PDE9A_MOUSE High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A DICER_MOUSE Endoribonuclease Dicer RGS1_MOUSE Regulator of G-protein signaling 1 RPTOR_MOUSE Regulatory-associated protein of mTOR NOL8_MOUSE Nucleolar protein 8 GLCI1_MOUSE Glucocorticoid-induced transcript 1 protein S35B2_MOUSE Adenosine 3'-phospho 5'-phosphosulfate transporter 1 Q80X68_MOUSE Citrate synthase CCNH_MOUSE Cyclin-H ALS2_MOUSE Alsin STEA3_MOUSE Metalloreductase STEAP3 SOAT1_MOUSE Sterol O-acyltransferase 1 CD2B2_MOUSE CD2 antigen cytoplasmic tail-binding protein 2 MPP8_MOUSE M-phase phosphoprotein 8 WASF1_MOUSE Wiskott-Aldrich syndrome protein family member 1 IQCB1_MOUSE IQ calmodulin-binding motif-containing protein 1 SCAM1_MOUSE Secretory carrier-associated membrane protein 1 TNAP2_MOUSE Tumor necrosis factor alpha-induced protein 2 DPOLZ_MOUSE DNA polymerase zeta catalytic subunit MPRD_MOUSE Cation-dependent mannose-6-phosphate receptor NUDT7_MOUSE Peroxisomal coenzyme A diphosphatase NUDT7 CEBPZ_MOUSE CCAAT/enhancer-binding protein zeta SHPK_MOUSE Sedoheptulokinase NOM1_MOUSE Nucleolar MIF4G domain-containing protein 1 TANC1_MOUSE Protein TANC1 CERS5_MOUSE Ceramide synthase 5 REEP4_MOUSE Receptor expression-enhancing protein 4 NXT1_MOUSE NTF2-related export protein 1 CSK_MOUSE Tyrosine-protein kinase CSK ELYS_MOUSE Protein ELYS EP400_MOUSE E1A-binding protein p400 SPTCS_MOUSE Spatacsin SAS10_MOUSE Something about silencing protein 10 RENR_MOUSE Renin receptor YES_MOUSE Tyrosine-protein kinase Yes BORG5_MOUSE Cdc42 effector protein 1 TSN31_MOUSE Tetraspanin-31 E9QAH1_MOUSE Protein Golgb1 BCAS3_MOUSE Breast carcinoma-amplified sequence 3 homolog MET18_MOUSE Histidine protein methyltransferase 1 homolog TERF2_MOUSE Telomeric repeat-binding factor 2 CF047_MOUSE Uncharacterized protein C6orf47 homolog RM55_MOUSE 39S ribosomal protein L55, mitochondrial RBMX_MOUSE RNA-binding motif protein, X chromosome C102A_MOUSE Coiled-coil domain-containing protein 102A AP1G2_MOUSE AP-1 complex subunit gamma-like 2 ATP7A_MOUSE Copper-transporting ATPase 1 COX20_MOUSE Cytochrome c oxidase protein 20 homolog IMA1_MOUSE Importin subunit alpha-1 VAMP7_MOUSE Vesicle-associated membrane protein 7 LRP6_MOUSE Low-density lipoprotein receptor-related protein 6 EPMIP_MOUSE EPM2A-interacting protein 1 ECT2_MOUSE Protein ECT2 DHR11_MOUSE Dehydrogenase/reductase SDR family member 11 ARI1_MOUSE E3 ubiquitin-protein ligase ARIH1 Q8BH78_MOUSE Reticulon ABHEB_MOUSE Alpha/beta hydrolase domain-containing protein 14B RB22A_MOUSE Ras-related protein Rab-22A KMT2A_MOUSE Histone-lysine N-methyltransferase 2A MED1_MOUSE Mediator of RNA polymerase II transcription subunit 1
EP
Ints6 Slc7a1 Pde9a Dicer1 Rgs1 Rptor Nol8 Glcci1 Slc35b2 Csl Ccnh Als2 Steap3 Soat1 Cd2bp2 Mphosph8 Wasf1 Iqcb1 Scamp1 Tnfaip2 Rev3l M6pr Nudt7 Cebpz Shpk Nom1 Tanc1 Cers5 Reep4 Nxt1 Csk Ahctf1 Ep400 Spg11 Utp3 Atp6ap2 Yes1 Cdc42ep1 Tspan31 Golgb1 Bcas3 Mettl18 Terf2 D17h6s53e Mrpl55 Rbmx Ccdc102a Ap1g2 Atp7a Cox20 Kpna2 Vamp7 Lrp6 Epm2aip1 Ect2 Dhrs11 Arih1 Rtn4 Abhd14b Rab22a Kmt2a Med1
AC C
sp|Q6PCM2|INT6_MOUSE sp|Q09143|CTR1_MOUSE sp|O70628|PDE9A_MOUSE sp|Q8R418|DICER_MOUSE sp|Q9JL25|RGS1_MOUSE sp|Q8K4Q0|RPTOR_MOUSE sp|Q3UHX0|NOL8_MOUSE sp|Q8K3I9|GLCI1_MOUSE sp|Q91ZN5|S35B2_MOUSE tr|Q80X68|Q80X68_MOUSE sp|Q61458|CCNH_MOUSE sp|Q920R0|ALS2_MOUSE sp|Q8CI59|STEA3_MOUSE sp|Q61263|SOAT1_MOUSE sp|Q9CWK3|CD2B2_MOUSE sp|Q3TYA6|MPP8_MOUSE sp|Q8R5H6|WASF1_MOUSE sp|Q8BP00|IQCB1_MOUSE sp|Q8K021|SCAM1_MOUSE sp|Q61333|TNAP2_MOUSE sp|Q61493|DPOLZ_MOUSE sp|P24668|MPRD_MOUSE sp|Q99P30|NUDT7_MOUSE sp|P53569|CEBPZ_MOUSE sp|Q9D5J6|SHPK_MOUSE sp|Q3UFM5|NOM1_MOUSE sp|Q0VGY8|TANC1_MOUSE sp|Q9D6K9|CERS5_MOUSE sp|Q8K072|REEP4_MOUSE sp|Q9QZV9|NXT1_MOUSE sp|P41241|CSK_MOUSE sp|Q8CJF7|ELYS_MOUSE sp|Q8CHI8|EP400_MOUSE sp|Q3UHA3|SPTCS_MOUSE sp|Q9JI13|SAS10_MOUSE sp|Q9CYN9|RENR_MOUSE sp|Q04736|YES_MOUSE sp|Q91W92|BORG5_MOUSE sp|Q9CQ88|TSN31_MOUSE tr|E9QAH1|E9QAH1_MOUSE sp|Q8CCN5|BCAS3_MOUSE sp|Q9CZ09|MET18_MOUSE sp|O35144|TERF2_MOUSE sp|Q9Z1R4|CF047_MOUSE sp|Q9CZ83|RM55_MOUSE sp|Q9WV02|RBMX_MOUSE sp|Q3TMW1|C102A_MOUSE sp|O88512|AP1G2_MOUSE sp|Q64430|ATP7A_MOUSE sp|Q9D7J4|COX20_MOUSE sp|P52293|IMA1_MOUSE sp|P70280|VAMP7_MOUSE sp|O88572|LRP6_MOUSE sp|Q8VEH5|EPMIP_MOUSE sp|Q07139|ECT2_MOUSE sp|Q3U0B3|DHR11_MOUSE sp|Q9Z1K5|ARI1_MOUSE tr|Q8BH78|Q8BH78_MOUSE sp|Q8VCR7|ABHEB_MOUSE sp|P35285|RB22A_MOUSE sp|P55200|KMT2A_MOUSE sp|Q925J9|MED1_MOUSE
55.0854 34.6565 23.2935 59.1314 121.398 25.9581 49.2929 142.901 78.9709 18.6786 40.9901 14.6741 52.1227 61.68 49.7873 75.0567 35.0477 63.2174 68.0736 105.859 19.6789 70.0601 51.2204 82.6652 43.2206 140.585 65.7083 54.656 68.1105 11.7517 77.0269 21.518 47.522 55.1815 32.3132 31.6211 41.3273 48.5799 23.0084 23.8465 24.5248 32.7125 43.9846 30.1196 98.1752 37.0379 63.0058 55.3139 48.0466 62.2646 44.4333 30.297 98.6862 78.175 84.7278 45.0646 53.8107 69.3388 78.7722 26.0381 41.2609 27.9213
67.6548 85.9097 14.9879 31.9618 1.04265 43.8137 92.7197 55.8652 85.6746 17.0438 29.7745 21.5212 47.0559 164.438 64.7593 48.523 28.2649 59.9931 57.1542 106.743 26.4119 173.423 24.4844 100.049 19.2782 121.425 42.4766 57.97 88.6072 180.404 95.2595 143.806 64.2067 81.8646 34.8549 30.7774 41.7948 12.7029 27.8121 25.3946 44.8667 34.8958 47.4762 14.662 25.7149 23.4058 24.8677 46.0033 75.1343 53.5706 23.2446 39.4956 52.525 48.5141 113.86 41.8272 42.0555 33.92 26.7488 35.0617 26.3593 22.4576
38.7735 29.0005 18.5253 50.1299 9.8572 30.9565 53.8944 99.6231 60.7806 14.7235 21.8499 42.9904 39.2254 102.031 153.994 65.2547 51.2018 22.7012 45.5453 81.0582 23.7364 68.8533 40.7749 45.2902 27.419 111.898 35.7103 44.3752 54.7342 252.662 64.3501 121.385 80.2334 56.3806 18.2127 34.1725 61.7163 16.9313 20.3501 56.2204 54.4042 28.1943 31.1536 22.4617 92.3345 44.7129 56.5926 35.5366 45.9673 80.1684 44.2968 28.4218 76.7961 66.199 186.226 85.6281 59.4782 27.1988 66.5211 26.611 37.1052 41.3856
1.24 1.24 1.24 1.23 1.23 1.23 1.23 1.23 1.23 1.23 1.23 1.23 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.22 1.21 1.21 1.21 1.21 1.21 1.21 1.21 1.21 1.21 1.21 1.21 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.20 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.19 1.18 1.18
1.13 2.31 0.86 0.87 0.06 1.57 1.70 0.54 0.98 0.76 0.69 1.77 0.84 2.10 2.42 0.77 1.25 0.78 0.77 1.01 1.56 2.60 0.81 1.17 0.62 1.22 0.68 0.89 1.19 17.81 1.07 5.84 1.72 1.29 0.90 1.13 1.40 0.33 1.14 2.05 1.88 1.13 0.79 0.65 0.69 1.03 0.72 0.71 1.27 1.06 1.05 1.21 0.81 0.84 1.27 1.16 0.97 0.68 0.66 1.26 0.80 1.29
ACCEPTED MANUSCRIPT
53.3475 40.3435 29.8705 43.155 58.6303 32.0138 57.203 49.1776 46.6701 56.5522 49.8955 16.0622 21.325 73.0333 23.3878 31.4708 41.3635 45.262 41.545 49.6456 36.403 70.0845 47.4306 79.8612 52.5917 17.1801 48.3481 65.7858 105.495 22.5001 30.7865 45.8298 22.9094 69.769 18.6769 46.9658 116.191 48.3468 23.8044 83.993 38.479 58.0112 29.6486 69.9675 24.407 40.0755 46.4099 23.5738 18.6497 17.7139 35.6118 74.5773 63.8682 124.212 40.5022 35.3668 132.029 25.6322 101.25 15.5497 44.6216 18.6303
72.838 70.2759 44.9926 57.5565 59.8707 52.3508 70.9945 38.4101 68.6291 49.9216 72.7654 20.6207 25.9798 104.543 29.142 39.4033 60.6953 66.9429 43.0595 63.8378 56.7828 109.018 71.0328 93.8933 37.1625 19.9833 67.1801 81.2237 113.394 29.203 40.0793 50.8868 24.9929 80.7506 34.9148 52.4824 143.962 60.5524 30.7708 79.7695 37.5507 70.1111 35.4501 72.8958 40.5389 50.5487 82.3499 33.5097 26.7685 18.4242 44.9765 80.0504 76.0166 171.061 50.0029 51.2304 142.399 38.8355 118.122 23.8161 55.6327 21.8959
RI PT
49.2469 53.6568 32.7313 43.3289 46.4644 44.7806 53.1896 36.843 67.6512 39.4391 59.0631 16.1701 16.6316 92.5156 23.6846 33.2979 48.7904 50.7432 32.1925 49.2238 45.1756 91.5689 56.6123 68.8078 44.8688 17.8329 51.5753 73.7237 92.5404 28.3682 35.3976 39.7259 15.8748 58.1949 27.4161 47.8378 120.437 59.7446 27.67 62.3739 35.9653 79.571 27.8578 69.1275 32.9803 38.6945 83.0917 29.2898 30.1801 15.5195 35.1031 57.4419 69.8658 113.124 46.4808 42.5602 92.4313 31.5586 105.738 18.269 48.9524 19.0855
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
TE D
Bysl Uhrf1bp1 Mif4gd Dnmbp Rgl2 Cyhr1 Smg9 Trub1 Parp12 Lcor Lemd2 Pop1 Tgoln2 Cuedc1 Tfip11 Rap1b Usp33 Dennd4a Gm6710 Med24 Oard1 Polr1b Kdm6b Vcan Slc37a2 Ei24 Ddah2 Yipf3 Aars2 Pvrl2 Gas6 Ago2 Stard3 Znf532 Fam208a Git1 Golga7 Prpf18 Tsr1 Mrpl38 Ldlrap1 Cdkn1b Thg1l Wfs1 Orc3 Mib1
ERI3_MOUSE ERI1 exoribonuclease 3 MICA3_MOUSE Protein-methionine sulfoxide oxidase MICAL3 SYNJ1_MOUSE Synaptojanin-1 TSTD3_MOUSE Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3 RDH14_MOUSE Retinol dehydrogenase 14 PKN2_MOUSE Serine/threonine-protein kinase N2 TBG1_MOUSE Tubulin gamma-1 chain PK3CA_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform THRB_MOUSE Prothrombin SDOS_MOUSE Protein syndesmos INO1_MOUSE Inositol-3-phosphate synthase 1 MTA70_MOUSE N6-adenosine-methyltransferase subunit METTL3 NFAT5_MOUSE Nuclear factor of activated T-cells 5 TMM59_MOUSE Transmembrane protein 59 RM52_MOUSE 39S ribosomal protein L52, mitochondrial CB043_MOUSE UPF0554 protein C2orf43 homolog BYST_MOUSE Bystin B2KF50_MOUSE Protein Uhrf1bp1 MI4GD_MOUSE MIF4G domain-containing protein DNMBP_MOUSE Dynamin-binding protein RGL2_MOUSE Ral guanine nucleotide dissociation stimulator-like 2 CYHR1_MOUSE Cysteine and histidine-rich protein 1 SMG9_MOUSE Protein SMG9 TRUB1_MOUSE Probable tRNA pseudouridine synthase 1 PAR12_MOUSE Poly [ADP-ribose] polymerase 12 LCOR_MOUSE Ligand-dependent corepressor LEMD2_MOUSE LEM domain-containing protein 2 Q8K205_MOUSE Blood vessel epicardial substance TGON2_MOUSE Trans-Golgi network integral membrane protein 2 CUED1_MOUSE CUE domain-containing protein 1 TFP11_MOUSE Tuftelin-interacting protein 11 RAP1B_MOUSE Ras-related protein Rap-1b UBP33_MOUSE Ubiquitin carboxyl-terminal hydrolase 33 E9Q8V6_MOUSE Protein Dennd4a A2ART0_MOUSE Protein Gm14391 MED24_MOUSE Mediator of RNA polymerase II transcription subunit 24 OARD1_MOUSE O-acetyl-ADP-ribose deacetylase 1 RPA2_MOUSE DNA-directed RNA polymerase I subunit RPA2 KDM6B_MOUSE Lysine-specific demethylase 6B CSPG2_MOUSE Versican core protein SPX2_MOUSE Sugar phosphate exchanger 2 EI24_MOUSE Etoposide-induced protein 2.4 DDAH2_MOUSE N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 YIPF3_MOUSE Protein YIPF3 SYAM_MOUSE Alanine--tRNA ligase, mitochondrial PVRL2_MOUSE Nectin-2 GAS6_MOUSE Growth arrest-specific protein 6 AGO2_MOUSE Protein argonaute-2 STAR3_MOUSE StAR-related lipid transfer protein 3 ZN532_MOUSE Zinc finger protein 532 F208A_MOUSE Protein FAM208A GIT1_MOUSE ARF GTPase-activating protein GIT1 GOGA7_MOUSE Golgin subfamily A member 7 PRP18_MOUSE Pre-mRNA-splicing factor 18 TSR1_MOUSE Pre-rRNA-processing protein TSR1 homolog RM38_MOUSE 39S ribosomal protein L38, mitochondrial ARH_MOUSE Low density lipoprotein receptor adapter protein 1 CDN1B_MOUSE Cyclin-dependent kinase inhibitor 1B THG1_MOUSE Probable tRNA(His) guanylyltransferase WFS1_MOUSE Wolframin ORC3_MOUSE Origin recognition complex subunit 3 MIB1_MOUSE E3 ubiquitin-protein ligase MIB1
EP
Eri3 Mical3 Synj1 Tstd3 Rdh14 Pkn2 Tubg1 Pik3ca F2 Nudt16l1 Isyna1 Mettl3 Nfat5 Tmem59 Mrpl52
AC C
sp|Q8C460|ERI3_MOUSE sp|Q8CJ19|MICA3_MOUSE sp|Q8CHC4|SYNJ1_MOUSE sp|Q9D0B5|TSTD3_MOUSE sp|Q9ERI6|RDH14_MOUSE sp|Q8BWW9|PKN2_MOUSE sp|P83887|TBG1_MOUSE sp|P42337|PK3CA_MOUSE sp|P19221|THRB_MOUSE sp|Q8VHN8|SDOS_MOUSE sp|Q9JHU9|INO1_MOUSE sp|Q8C3P7|MTA70_MOUSE sp|Q9WV30|NFAT5_MOUSE sp|Q9QY73|TMM59_MOUSE sp|Q9D0Y8|RM52_MOUSE sp|Q8BVA5|CB043_MOUSE sp|O54825|BYST_MOUSE tr|B2KF50|B2KF50_MOUSE sp|Q3UBZ5|MI4GD_MOUSE sp|Q6TXD4|DNMBP_MOUSE sp|Q61193|RGL2_MOUSE sp|Q9QXA1|CYHR1_MOUSE sp|Q9DB90|SMG9_MOUSE sp|Q8C0D0|TRUB1_MOUSE sp|Q8BZ20|PAR12_MOUSE sp|Q6ZPI3|LCOR_MOUSE sp|Q6DVA0|LEMD2_MOUSE tr|Q8K205|Q8K205_MOUSE sp|Q62314|TGON2_MOUSE sp|Q8R3V6|CUED1_MOUSE sp|Q9ERA6|TFP11_MOUSE sp|Q99JI6|RAP1B_MOUSE sp|Q8R5K2|UBP33_MOUSE tr|E9Q8V6|E9Q8V6_MOUSE tr|A2ART0|A2ART0_MOUSE sp|Q99K74|MED24_MOUSE sp|Q8R5F3|OARD1_MOUSE sp|P70700|RPA2_MOUSE sp|Q5NCY0|KDM6B_MOUSE sp|Q62059|CSPG2_MOUSE sp|Q9WU81|SPX2_MOUSE sp|Q61070|EI24_MOUSE sp|Q99LD8|DDAH2_MOUSE sp|Q3UDR8|YIPF3_MOUSE sp|Q14CH7|SYAM_MOUSE sp|P32507|PVRL2_MOUSE sp|Q61592|GAS6_MOUSE sp|Q8CJG0|AGO2_MOUSE sp|Q61542|STAR3_MOUSE sp|Q6NXK2|ZN532_MOUSE sp|Q69ZR9|F208A_MOUSE sp|Q68FF6|GIT1_MOUSE sp|Q91W53|GOGA7_MOUSE sp|Q8BM39|PRP18_MOUSE sp|Q5SWD9|TSR1_MOUSE sp|Q8K2M0|RM38_MOUSE sp|Q8C142|ARH_MOUSE sp|P46414|CDN1B_MOUSE sp|Q9CY52|THG1_MOUSE sp|P56695|WFS1_MOUSE sp|Q9JK30|ORC3_MOUSE sp|Q80SY4|MIB1_MOUSE
48.3083 40.7088 28.8899 44.5011 64.123 38.2476 59.1006 62.8298 65.7168 62.7948 55.1371 17.2116 18.5243 89.5306 26.0242 36.4719 44.8782 45.4476 43.2499 51.8826 38.6666 80.0352 50.4091 79.5169 76.3447 20.7853 49.1636 81.0469 116.884 29.8829 36.7429 48.2527 19.9318 67.3363 18.3494 56.996 128.923 64.026 28.5221 88.6856 48.0979 88.1319 30.6519 86.9853 25.3418 39.8241 66.1964 27.1247 29.1969 19.6154 35.9474 70.9706 76.932 100.185 49.3891 37.8009 114.04 26.2164 117.278 14.6202 50.6534 20.8717
63.3653 27.9192 33.6207 28.1037 44.6839 41.0718 81.8636 25.9498 163.972 98.5601 56.2821 19.5564 32.1111 91.4114 11.8198 39.8135 114.315 42.7285 47.8895 79.4044 55.3143 90.8124 67.1912 75.0363 21.8275 12.6479 60.0848 101.094 149.387 13.4156 47.2505 101.716 15.4384 151.736 73.6572 72.8593 118.519 46.3037 59.6382 41.4237 40.2052 66.0404 141.571 61.599 19.572 45.7333 31.4836 55.378 30.2421 25.5899 25.4979 76.2191 75.3631 155.205 36.1867 34.5125 135.216 25.77 109.009 24.9327 37.0316 17.5498
49.3755 31.8472 23.7461 112.249 51.1019 49.2246 56.4814 47.1755 102.975 39.1253 54.4197 29.9997 7.37015 96.0527 33.6314 40.4259 393.842 43.2449 62.5933 188.381 39.1947 84.4418 25.9943 110.128 50.0988 23.5124 38.8052 99.9378 148.82 41.1913 51.4013 53.9922 34.2367 86.1299 82.0987 54.6544 113.737 42.7081 118.42 178.662 20.6331 63.8228 155.887 59.2475 66.1857 37.5446 29.503 36.3787 21.9586 36.4685 29.9477 147.88 65.8917 129.053 37.0102 59.2647 110.912 32.9655 128.587 10.5539 22.6491 18.7666
1.18 1.18 1.18 1.18 1.18 1.18 1.18 1.18 1.18 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.17 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.16 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.15 1.14 1.14 1.14 1.14 1.14 1.14 1.14 1.14 1.14 1.14 1.14 1.14 1.13
1.10 0.64 0.92 1.62 0.91 1.18 1.25 0.85 2.34 1.43 1.02 1.54 1.04 1.13 0.97 1.24 5.64 0.90 1.50 2.71 1.16 1.08 0.90 1.25 0.74 1.03 0.99 1.44 1.51 1.07 1.49 1.82 1.28 1.86 3.38 1.35 0.98 0.82 3.46 1.50 0.82 0.94 5.17 0.87 1.49 1.06 0.47 1.74 1.07 1.87 0.78 1.70 1.06 1.20 0.84 1.20 1.10 1.03 1.15 1.05 0.64 0.96
ACCEPTED MANUSCRIPT
TE D
32.7779 39.0474 63.7276 34.7995 45.0757 18.7307 44.9331 66.4763 107.78 59.3482 69.0183 49.4912 23.3896 137.333 35.6434 58.5213 47.5583 177.844 18.8001 44.5515 46.8169 144.105 58.665 22.3391 25.2648 57.0954 68.8313 43.8156 45.0932 146.391 130.06 69.9482 71.1652 21.6472 49.3778 35.9637 83.1449 93.3531 19.4247 77.4742 29.1164 14.1506 36.3013 35.2252 17.0601 44.5382 53.1278 41.4031 66.9408 34.3844 58.3084 33.7789 38.466 54.8317 36.9184 32.6602 57.0027 67.4921 81.0191 6.51729 99.7642 33.6723
38.5076 44.668 90.5981 36.764 47.6354 20.2246 60.8327 94.1561 109.575 83.3102 81.544 65.413 35.5297 205.56 47.6849 80.8341 63.6697 160.666 23.6828 64.919 54.6786 158.404 64.4866 19.709 41.1746 63.4722 60.7802 52.2121 64.2493 125.887 174.458 69.361 85.2103 27.1168 61.164 48.4083 85.4541 115.439 24.2509 92.7349 40.7402 19.1937 43.6733 41.4202 26.738 52.3965 82.9758 48.0259 99.2128 53.3526 71.1209 40.9284 51.62 65.42 41.6316 47.3168 63.455 90.9118 103.982 7.46678 139.403 41.4462
SC
RI PT
28.634 37.4091 73.2483 25.2172 35.2749 15.5725 45.866 86.726 115.251 66.8367 75.6636 54.1907 37.2083 163.794 41.6948 69.1471 55.8333 168.881 22.4319 61.9802 51.5364 148.786 49.6012 11.0687 35.2478 62.7048 56.9128 38.6549 50.1277 102.654 131.04 52.4186 83.7823 21.639 53.0911 45.9648 81.113 108.461 18.2975 76.4748 34.7014 18.4604 38.2213 40.2524 25.9711 47.8526 72.8771 37.3003 87.616 45.9265 56.919 34.8499 53.3629 68.8617 35.3589 39.9873 56.5033 84.4216 87.9847 6.0039 124.382 34.5444
M AN U
HDDC2_MOUSE HD domain-containing protein 2 1 E9PY46_MOUSE Protein Ift140 1 KC1G3_MOUSE Casein kinase I isoform gamma-3 1 PEBB_MOUSE Core-binding factor subunit beta 1 WDR7_MOUSE WD repeat-containing protein 7 1 RYR3_MOUSE Ryanodine receptor 3 1 RCD1_MOUSE Cell differentiation protein RCD1 homolog 1 NAL9A_MOUSE NACHT, LRR and PYD domains-containing protein 9A 1 B2RVE2_MOUSE Protein Rergl 1 MFN1_MOUSE Mitofusin-1 1 PYRD1_MOUSE Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 1 UXS1_MOUSE UDP-glucuronic acid decarboxylase 1 1 AT11C_MOUSE Probable phospholipid-transporting ATPase 11C 1 TOR3A_MOUSE Torsin-3A 1 Q7TMC8_MOUSE L-fucose kinase 1 SUMF1_MOUSE Sulfatase-modifying factor 1 1 CAMLG_MOUSE Calcium signal-modulating cyclophilin ligand 1 AP4B1_MOUSE AP-4 complex subunit beta-1 1 C2CD5_MOUSE C2 domain-containing protein 5 1 OSBL3_MOUSE Oxysterol-binding protein-related protein 3 1 RIC8A_MOUSE Synembryn-A 1 GHITM_MOUSE Growth hormone-inducible transmembrane protein 1 ALG13_MOUSE Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG131 HTR5B_MOUSE HEAT repeat-containing protein 5B 1 FOXO3_MOUSE Forkhead box protein O3 1 PTCD1_MOUSE Pentatricopeptide repeat-containing protein 1, mitochondrial 1 NFKB1_MOUSE Nuclear factor NF-kappa-B p105 subunit 1 CO4B_MOUSE Complement C4-B 1 IQCE_MOUSE IQ domain-containing protein E 1 TXND9_MOUSE Thioredoxin domain-containing protein 9 1 D6RGQ8_MOUSE Protein Arhgef11 1 E9PZP8_MOUSE Protein Herc1 1 UB2Q2_MOUSE Ubiquitin-conjugating enzyme E2 Q2 1 TM115_MOUSE Transmembrane protein 115 1 TBC17_MOUSE TBC1 domain family member 17 1 HDAC5_MOUSE Histone deacetylase 5 1 PNISR_MOUSE Arginine/serine-rich protein PNISR 1 NDUB9_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 1 CCD53_MOUSE WASH complex subunit CCDC53 1 ABR_MOUSE Active breakpoint cluster region-related protein 1 MET14_MOUSE N6-adenosine-methyltransferase subunit METTL14 1 MSH6_MOUSE DNA mismatch repair protein Msh6 1 DHX36_MOUSE ATP-dependent RNA helicase DHX36 1 RHG10_MOUSE Rho GTPase-activating protein 10 1 RIR1_MOUSE Ribonucleoside-diphosphate reductase large subunit 1 ATG2B_MOUSE Autophagy-related protein 2 homolog B 1 PDK2_MOUSE [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 1 DOCK8_MOUSE Dedicator of cytokinesis protein 8 1 SPCS1_MOUSE Signal peptidase complex subunit 1 1 PCIF1_MOUSE Phosphorylated CTD-interacting factor 1 1 F6Q8N5_MOUSE Protein Upf3b (Fragment) 1 RUSD2_MOUSE RNA pseudouridylate synthase domain-containing protein 2 1 DP13A_MOUSE DCC-interacting protein 13-alpha 1 TF2H2_MOUSE General transcription factor IIH subunit 2 1 GCFC2_MOUSE GC-rich sequence DNA-binding factor 2 1 HM20A_MOUSE High mobility group protein 20A 1 TULP3_MOUSE Tubby-related protein 3 1 S12A7_MOUSE Solute carrier family 12 member 7 1 UBTD2_MOUSE Ubiquitin domain-containing protein 2 1 B9EJR8_MOUSE HEAT repeat containing 2 1 ASM_MOUSE Sphingomyelin phosphodiesterase 1 RPP40_MOUSE Ribonuclease P protein subunit p40 1
EP
Hddc2 Ift140 Csnk1g3 Cbfb Wdr7 Ryr3 Rqcd1 Nlrp9a Rergl Mfn1 Pyroxd1 Uxs1 Atp11c Tor3a Fuk Sumf1 Camlg Ap4b1 C2cd5 Osbpl3 Ric8a Ghitm Alg13 Heatr5b Foxo3 Ptcd1 Nfkb1 C4b Iqce Txndc9 Arhgef11 Herc1 Ube2q2 Tmem115 Tbc1d17 Hdac5 Pnisr Ndufb9 Ccdc53 Abr Mettl14 Msh6 Dhx36 Arhgap10 Rrm1 Atg2b Pdk2 Dock8 Spcs1 Pcif1 Upf3b Rpusd2 Appl1 Gtf2h2 Gcfc2 Hmg20a Tulp3 Slc12a7 Ubtd2 Heatr2 Smpd1 Rpp40
AC C
sp|Q3SXD3|HDDC2_MOUSE tr|E9PY46|E9PY46_MOUSE sp|Q8C4X2|KC1G3_MOUSE sp|Q08024|PEBB_MOUSE sp|Q920I9|WDR7_MOUSE sp|A2AGL3|RYR3_MOUSE sp|Q9JKY0|RCD1_MOUSE sp|Q66X03|NAL9A_MOUSE tr|B2RVE2|B2RVE2_MOUSE sp|Q811U4|MFN1_MOUSE sp|Q3TMV7|PYRD1_MOUSE sp|Q91XL3|UXS1_MOUSE sp|Q9QZW0|AT11C_MOUSE sp|Q9ER38|TOR3A_MOUSE tr|Q7TMC8|Q7TMC8_MOUSE sp|Q8R0F3|SUMF1_MOUSE sp|P49070|CAMLG_MOUSE sp|Q9WV76|AP4B1_MOUSE sp|Q7TPS5|C2CD5_MOUSE sp|Q9DBS9|OSBL3_MOUSE sp|Q3TIR3|RIC8A_MOUSE sp|Q91VC9|GHITM_MOUSE sp|Q9D8C3|ALG13_MOUSE sp|Q8C547|HTR5B_MOUSE sp|Q9WVH4|FOXO3_MOUSE sp|Q8C2E4|PTCD1_MOUSE sp|P25799|NFKB1_MOUSE sp|P01029|CO4B_MOUSE sp|Q6PCQ0|IQCE_MOUSE sp|Q9CQ79|TXND9_MOUSE tr|D6RGQ8|D6RGQ8_MOUSE tr|E9PZP8|E9PZP8_MOUSE sp|Q8K2Z8|UB2Q2_MOUSE sp|Q9WUH1|TM115_MOUSE sp|Q8BYH7|TBC17_MOUSE sp|Q9Z2V6|HDAC5_MOUSE sp|A2AJT4|PNISR_MOUSE sp|Q9CQJ8|NDUB9_MOUSE sp|Q9CR27|CCD53_MOUSE sp|Q5SSL4|ABR_MOUSE sp|Q3UIK4|MET14_MOUSE sp|P54276|MSH6_MOUSE sp|Q8VHK9|DHX36_MOUSE sp|Q6Y5D8|RHG10_MOUSE sp|P07742|RIR1_MOUSE sp|Q80XK6|ATG2B_MOUSE sp|Q9JK42|PDK2_MOUSE sp|Q8C147|DOCK8_MOUSE sp|Q9D958|SPCS1_MOUSE sp|P59114|PCIF1_MOUSE tr|F6Q8N5|F6Q8N5_MOUSE sp|Q149F1|RUSD2_MOUSE sp|Q8K3H0|DP13A_MOUSE sp|Q9JIB4|TF2H2_MOUSE sp|Q8BKT3|GCFC2_MOUSE sp|Q9DC33|HM20A_MOUSE sp|O88413|TULP3_MOUSE sp|Q9WVL3|S12A7_MOUSE sp|Q6PGH0|UBTD2_MOUSE tr|B9EJR8|B9EJR8_MOUSE sp|Q04519|ASM_MOUSE sp|Q8R1F9|RPP40_MOUSE
31.0849 41.9678 64.5945 31.2272 43.3729 18.5428 41.7606 78.8392 142.18 58.9891 81.5691 51.4709 32.7629 133.512 39.3172 62.768 52.5898 229.193 22.6103 54.6343 55.5741 169.423 56.5323 17.6222 26.4258 70.3192 79.6476 39.8506 41.9884 151.968 116.664 67.0426 86.7636 20.9097 52.5133 42.4572 96.5445 108.148 17.508 77.5415 29.839 16.8706 38.6078 41.8598 20.729 49.4438 55.8097 38.6562 70.9313 35.0009 55.5677 34.525 49.3168 70.3929 37.6861 32.368 60.9959 75.3756 80.9984 6.22691 105.726 33.1287
5.34436 37.5747 64.2595 34.2059 51.1013 15.615 46.1969 0.745896 145.881 41.0545 75.1826 41.7604 24.42 83.2748 58.6991 46.2256 44.3157 241.334 24.548 65.3654 60.713 281.331 48.0221 22.4252 27.3255 53.1842 89.8929 30.8338 39.0314 137.126 196.311 68.457 74.531 22.2513 80.4934 33.7364 15.7735 119.834 13.5163 61.9209 29.5329 22.1826 32.4502 41.2891 31.7496 31.5512 59.343 34.3307 73.9217 61.2046 39.0345 26.2862 28.1341 83.2273 34.3712 14.4788 53.7509 67.4064 100.386 119.456 82.5419 38.5176
37.5419 40.7233 43.2842 67.2434 40.4317 22.8789 54.6843 0 91.9195 35.034 67.3555 67.0675 23.4705 42.9329 51.3131 113.48 62.1434 190.369 23.3977 71.5948 44.1532 150.841 104.73 17.2422 25.6942 90.6522 136.057 45.4812 50.0924 204.735 350.88 52.1218 95.8775 11.3413 90.2272 107.211 43.0261 147.613 31.4267 66.8166 40.7482 8.87713 31.9983 31.0254 11.9869 41.6799 86.9743 82.4145 71.1565 32.7267 93.5756 39.4559 29.0526 61.7835 34.7438 36.226 94.4173 60.0757 167.932 50.6182 104 29.8211
1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.13 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.12 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.11 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.10 1.09 1.09 1.09 1.09 1.09
0.70 1.02 0.79 1.69 1.14 1.12 1.11 0.00 1.07 0.60 0.99 1.05 0.79 0.42 1.42 1.25 1.03 1.25 1.16 1.29 1.07 1.48 1.41 1.19 0.88 1.20 1.80 0.93 0.94 1.37 2.10 0.99 1.10 0.78 1.67 1.72 0.36 1.33 1.19 0.84 1.10 0.95 0.86 0.96 1.02 0.79 1.16 1.48 0.94 1.17 1.15 0.96 0.62 1.17 0.96 0.70 1.31 0.84 1.59 13.58 0.83 1.00
ACCEPTED MANUSCRIPT
56.7534 57.564 13.0434 62.4068 77.6896 58.667 24.2854 57.544 93.1461 17.2678 59.7264 125.641 44.9006 62.9367 5.05354 59.0616 36.3885 37.2543 45.0222 42.5484 50.6584 26.0584 46.9744 42.2303 71.9464 48.8387 17.9127 43.6815 47.2121 35.8153 32.7893 30.4896 51.2397 89.6524 28.3977 29.7256 47.9189 66.3345 29.3257 37.945 46.1279 37.7507 66.1524 116.085 43.9808 57.5068 16.4975 62.6575 58.8711 31.8775 13.9819 74.1983 17.3386 106.356 95.2664 9.31011 43.4112 44.5651 53.7368 55.8541 18.8564 52.8135
79.0056 29.6355 19.4039 56.6256 77.6044 74.6152 27.7713 67.4836 120.79 23.4987 85.0641 144.311 55.6848 75.5789 7.81709 82.5775 61.0445 43.3832 48.0031 54.2731 49.905 31.3095 28.2264 54.5784 93.4341 63.6964 23.2184 30.703 62.8497 42.8456 37.1419 30.7651 62.2489 103.279 30.5623 33.6858 45.5775 102.596 34.3583 43.8603 63.3282 47.9089 76.6594 128.05 56.7486 71.4654 15.8404 55.4789 71.4079 38.3217 13.828 89.7341 21.5784 103.827 104.373 13.7597 47.8404 46.5565 47.5713 60.2849 20.1522 67.1603
SC
RI PT
81.1819 44.8123 19.8866 39.6186 52.644 66.1456 21.0364 55.7149 104.593 19.6991 76.493 124.785 48.4037 79.0175 5.71617 74.6794 54.2299 36.0888 39.1748 49.4261 42.5402 29.444 37.0469 47.474 88.3869 47.481 19.9841 21.3751 52.5148 35.1225 29.4807 28.6656 56.8912 87.4159 31.3903 31.6779 45.7434 92.0627 27.1887 44.4887 63.9855 44.8068 68.213 116.13 55.143 59.0961 12.4863 51.8554 56.603 34.4331 10.0271 77.8777 18.1486 118.255 91.9071 10.3357 45.1914 36.1969 48.0038 46.1409 14.241 56.9126
M AN U
Pde6d Hm13 Mtmr12 Acss3 Tpst2 Tmem11 Alas1 Degs1 Snx15 Ift46 Slc30a1 Nkiras2 Bms1 Pon3 Edc4 Hspbp1 Paox Patl1 Smarcd1 Samd4b Mepce Slc25a36 Spats2 Kat7 Smarcb1 Pptc7 Map1lc3a Ing3 Urm1 Adat2 Nrip1 Atp2c1 Vti1b Dph2 Tmpo Wipi1 Sh3d19 Cbfa2t3 Zfand1 Trps1 Aprt
TE D
Arid1b Ltv1 Mtr
WDR92_MOUSE WD repeat-containing protein 92 1 RRN3_MOUSE RNA polymerase I-specific transcription initiation factor RRN3 1 MIO_MOUSE WD repeat-containing protein mio 1 J3QMK2_MOUSE MCG22959, isoform CRA_a 1 MYPT2_MOUSE Protein phosphatase 1 regulatory subunit 12B 1 SPTC2_MOUSE Serine palmitoyltransferase 2 1 SWAHC_MOUSE Ankyrin repeat domain-containing protein SOWAHC 1 KTHY_MOUSE Thymidylate kinase 1 ITIH4_MOUSE Inter alpha-trypsin inhibitor, heavy chain 4 1 XRCC1_MOUSE DNA repair protein XRCC1 1 MERL_MOUSE Merlin 1 E9QJT3_MOUSE Vesicle transport protein SFT2C 1 ITSN2_MOUSE Intersectin-2 1 MPV17_MOUSE Protein Mpv17 1 TBC24_MOUSE TBC1 domain family member 24 1 MET16_MOUSE Methyltransferase-like protein 16 1 CD051_MOUSE Uncharacterized protein C4orf51 homolog 1 E9Q4N6_MOUSE Protein Arid1b 1 LTV1_MOUSE Protein LTV1 homolog 1 METH_MOUSE Methionine synthase 1 CG055_MOUSE UPF0562 protein C7orf55 homolog 1 PDE6D_MOUSE Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta 1 HM13_MOUSE Minor histocompatibility antigen H13 1 MTMRC_MOUSE Myotubularin-related protein 12 1 ACSS3_MOUSE Acyl-CoA synthetase short-chain family member 3, mitochondrial 1 TPST2_MOUSE Protein-tyrosine sulfotransferase 2 1 TMM11_MOUSE Transmembrane protein 11, mitochondrial 1 HEM1_MOUSE 5-aminolevulinate synthase, nonspecific, mitochondrial 1 DEGS1_MOUSE Sphingolipid delta(4)-desaturase DES1 1 SNX15_MOUSE Sorting nexin-15 1 IFT46_MOUSE Intraflagellar transport protein 46 homolog 1 ZNT1_MOUSE Zinc transporter 1 1 KBRS2_MOUSE NF-kappa-B inhibitor-interacting Ras-like protein 2 1 Q6PGF5_MOUSE BMS1 homolog, ribosome assembly protein (Yeast) 1 PON3_MOUSE Serum paraoxonase/lactonase 3 1 EDC4_MOUSE Enhancer of mRNA-decapping protein 4 1 HPBP1_MOUSE Hsp70-binding protein 1 1 PAOX_MOUSE Peroxisomal N(1)-acetyl-spermine/spermidine oxidase 1 PATL1_MOUSE Protein PAT1 homolog 1 1 SMRD1_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily 1 D member 1 SMAG2_MOUSE Protein Smaug homolog 2 1 MEPCE_MOUSE 7SK snRNA methylphosphate capping enzyme 1 S2536_MOUSE Solute carrier family 25 member 36 1 SPAS2_MOUSE Spermatogenesis-associated serine-rich protein 2 1 KAT7_MOUSE Histone acetyltransferase KAT7 1 SNF5_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B 1member 1 PPTC7_MOUSE Protein phosphatase PTC7 homolog 1 MLP3A_MOUSE Microtubule-associated proteins 1A/1B light chain 3A 1 ING3_MOUSE Inhibitor of growth protein 3 1 URM1_MOUSE Ubiquitin-related modifier 1 1 ADAT2_MOUSE tRNA-specific adenosine deaminase 2 1 NRIP1_MOUSE Nuclear receptor-interacting protein 1 1 AT2C1_MOUSE Calcium-transporting ATPase type 2C member 1 1 VTI1B_MOUSE Vesicle transport through interaction with t-SNAREs homolog 1B 1 DPH2_MOUSE Diphthamide biosynthesis protein 2 1 LAP2A_MOUSE Lamina-associated polypeptide 2, isoforms alpha/zeta 1 WIPI1_MOUSE WD repeat domain phosphoinositide-interacting protein 1 1 SH319_MOUSE SH3 domain-containing protein 19 1 MTG16_MOUSE Protein CBFA2T3 1 ZFAN1_MOUSE AN1-type zinc finger protein 1 1 TRPS1_MOUSE Zinc finger transcription factor Trps1 1 APT_MOUSE Adenine phosphoribosyltransferase 1
EP
Wdr92 Rrn3 Mios Bbip1 Ppp1r12b Sptlc2 Sowahc Dtymk Itih4 Xrcc1 Nf2 Sft2d3 Itsn2 Mpv17 Tbc1d24 Mettl16
AC C
sp|Q8BGF3|WDR92_MOUSE sp|B2RS91|RRN3_MOUSE sp|Q8VE19|MIO_MOUSE tr|J3QMK2|J3QMK2_MOUSE sp|Q8BG95|MYPT2_MOUSE sp|P97363|SPTC2_MOUSE sp|Q8C0J6|SWAHC_MOUSE sp|P97930|KTHY_MOUSE sp|A6X935|ITIH4_MOUSE sp|Q60596|XRCC1_MOUSE sp|P46662|MERL_MOUSE tr|E9QJT3|E9QJT3_MOUSE sp|Q9Z0R6|ITSN2_MOUSE sp|P19258|MPV17_MOUSE sp|Q3UUG6|TBC24_MOUSE sp|Q9CQG2|MET16_MOUSE sp|Q9DAF8|CD051_MOUSE tr|E9Q4N6|E9Q4N6_MOUSE sp|Q6NSQ7|LTV1_MOUSE sp|A6H5Y3|METH_MOUSE sp|Q9CR13|CG055_MOUSE sp|O55057|PDE6D_MOUSE sp|Q9D8V0|HM13_MOUSE sp|Q80TA6|MTMRC_MOUSE sp|Q14DH7|ACSS3_MOUSE sp|O88856|TPST2_MOUSE sp|Q8BK08|TMM11_MOUSE sp|Q8VC19|HEM1_MOUSE sp|O09005|DEGS1_MOUSE sp|Q91WE1|SNX15_MOUSE sp|Q9DB07|IFT46_MOUSE sp|Q60738|ZNT1_MOUSE sp|Q9CR56|KBRS2_MOUSE tr|Q6PGF5|Q6PGF5_MOUSE sp|Q62087|PON3_MOUSE sp|Q3UJB9|EDC4_MOUSE sp|Q99P31|HPBP1_MOUSE sp|Q8C0L6|PAOX_MOUSE sp|Q3TC46|PATL1_MOUSE sp|Q61466|SMRD1_MOUSE sp|Q80XS6|SMAG2_MOUSE sp|Q8K3A9|MEPCE_MOUSE sp|Q922G0|S2536_MOUSE sp|Q8K1N4|SPAS2_MOUSE sp|Q5SVQ0|KAT7_MOUSE sp|Q9Z0H3|SNF5_MOUSE sp|Q6NVE9|PPTC7_MOUSE sp|Q91VR7|MLP3A_MOUSE sp|Q8VEK6|ING3_MOUSE sp|Q9D2P4|URM1_MOUSE sp|Q6P6J0|ADAT2_MOUSE sp|Q8CBD1|NRIP1_MOUSE sp|Q80XR2|AT2C1_MOUSE sp|O88384|VTI1B_MOUSE sp|Q9CR25|DPH2_MOUSE sp|Q61033|LAP2A_MOUSE sp|Q8R3E3|WIPI1_MOUSE sp|Q91X43|SH319_MOUSE sp|O54972|MTG16_MOUSE sp|Q8BFR6|ZFAN1_MOUSE sp|Q925H1|TRPS1_MOUSE sp|P08030|APT_MOUSE
71.5329 82.0419 16.5176 54.6412 64.4577 61.2837 21.5727 55.8235 94.4245 16.7067 63.0466 127.904 45.6931 78.6176 3.87259 62.5772 37.2074 36.0168 43.1421 45.2684 50.9564 28.6527 62.5395 42.2762 79.5599 40.0888 17.5953 39.3215 44.4635 33.476 29.844 32.8262 53.979 87.0252 33.6635 32.2169 54.9466 67.3414 26.2595 44.4178 54.4353 40.3563 66.9579 119.963 49.1182 53.0501 15.095 66.6939 51.7577 32.379 11.7447 72.1798 16.1936 135.224 94.8208 7.13976 46.3913 39.229 60.4891 47.9463 14.9483 49.189
95.5799 36.0987 16.3148 35.7147 62.084 79.297 14.9398 22.9215 46.5481 5.50236 29.7222 133.71 45.7807 69.9232 199.317 26.6098 57.9174 36.7252 22.1887 44.7326 30.986 20.9639 49.5044 38.4231 26.8316 41.7567 132.917 129.976 36.1558 22.5853 24.8195 43.9745 34.2869 30.4506 39.8338 45.5896 64.0231 69.9774 27.1241 44.666 24.5848 22.8843 38.7768 97.9552 39.5878 57.0436 23.3311 60.6102 56.3085 24.1381 167.476 34.8956 18.759 108.121 83.1194 126.329 37.2379 16.6957 52.8645 28.4032 20.5875 84.9192
85.0304 53.0563 21.1717 119.824 143.746 65.4444 27.0475 69.1439 326.595 0 20.2619 98.9008 57.7703 69.005 467.807 63.8859 57.5801 58.7691 71.0272 46.6607 44.4097 35.1871 40.0638 77.627 79.7441 34.203 119.459 173.371 54.1039 57.8854 36.4432 44.6723 76.0267 13.8124 43.814 24.8991 52.3266 68.3272 23.5866 63.8558 51.5389 51.6394 31.7258 47.8549 40.3239 51.5278 87.9179 72.0662 136.032 53.3082 242.892 234.197 12.1023 81.724 258.315 116.794 51.9943 26.2805 117.598 41.7963 32.6455 63.4609
1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.09 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.08 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.07 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06
1.31 0.87 1.14 1.52 1.58 1.16 0.93 0.81 1.89 0.15 0.37 0.93 1.11 0.98 61.94 0.68 1.27 1.30 1.11 0.99 0.81 1.01 1.07 1.29 0.66 0.79 6.66 4.66 0.91 1.13 0.98 1.50 1.02 0.25 1.40 1.15 1.24 0.87 0.90 1.32 0.69 0.90 0.52 0.63 0.81 0.93 3.84 1.16 1.67 1.17 17.09 1.77 0.87 0.85 1.82 12.38 1.01 0.53 1.68 0.69 1.61 1.35
ACCEPTED MANUSCRIPT
TE D
24.7223 49.9818 65.6909 73.3688 91.8083 63.6731 86.2036 29.0853 31.3449 35.4851 53.4088 30.0437 32.021 30.7729 72.7953 58.7199 72.9767 44.96 32.2608 57.0622 69.3474 63.5984 20.999 26.4577 29.2097 56.4846 24.3739 65.1614 70.1788 43.2631 66.5134 32.5633 46.7311 55.8909 68.3034 60.0479 25.6039 47.5874 18.5173 43.2215 36.7468 36.2543 96.9127 63.3499 59.1485 42.4941 33.5278 31.5635 83.7558 32.7495 70.0492 10.9411 38.243 47.4658 37.8277 64.1285 42.4663 27.287 36.2278 22.5526 83.0713 38.5479
26.6341 47.8526 43.8161 69.6175 99.428 57.4998 101.496 37.9457 29.6348 39.6884 74.6928 39.169 39.5803 39.413 91.2775 63.9089 73.5585 57.3608 37.4837 73.8257 95.3802 73.3576 23.3219 41.2969 34.7733 67.8414 29.8453 84.9953 89.5178 72.9273 55.9356 44.157 56.3401 56.5089 90.2252 59.3725 32.3286 47.047 24.6702 50.0048 35.266 50.5325 101.505 71.6343 77.0409 56.8477 36.2886 42.8105 90.3953 33.0746 85.2039 10.1172 40.7172 47.9852 44.427 76.7454 42.8804 30.713 40.3149 27.4758 106.886 39.1144
RI PT
19.0789 43.5978 63.7598 58.4626 80.6755 74.1092 76.4195 42.6361 30.2969 28.53 65.4378 35.1737 29.4831 30.5827 81.4043 57.823 88.3027 56.8811 26.7845 66.6676 86.9351 61.982 16.2418 37.9569 33.8334 55.5455 22.7745 76.1703 78.5915 66.2177 55.7602 34.0449 54.0414 53.1303 81.9892 65.3628 29.1306 38.547 22.4323 44.9428 42.7235 42.9192 81.7303 65.9959 59.8616 54.0078 30.315 38.0837 70.5214 24.0249 72.4615 11.2647 35.3437 39.379 42.308 73.8532 38.5542 28.7225 42.9534 27.464 99.0266 35.0734
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
TDRD3_MOUSE Tudor domain-containing protein 3 LLPH_MOUSE Protein LLP homolog RL18A_MOUSE 60S ribosomal protein L18a CTC1_MOUSE CST complex subunit CTC1 A2ANC1_MOUSE Tyrosine-protein phosphatase non-receptor type substrate 1 (Fragment) RN123_MOUSE E3 ubiquitin-protein ligase RNF123 GREM1_MOUSE Gremlin-1 TMM65_MOUSE Transmembrane protein 65 GID4_MOUSE Glucose-induced degradation protein 4 homolog LIMD1_MOUSE LIM domain-containing protein 1 GPN1_MOUSE GPN-loop GTPase 1 NAA25_MOUSE N-alpha-acetyltransferase 25, NatB auxiliary subunit PTN2_MOUSE Tyrosine-protein phosphatase non-receptor type 2 ADXL_MOUSE Adrenodoxin-like protein, mitochondrial NUP37_MOUSE Nucleoporin Nup37 A6ZI47_MOUSE Fructose-bisphosphate aldolase TM7S3_MOUSE Transmembrane 7 superfamily member 3 PRP39_MOUSE Pre-mRNA-processing factor 39 HPCL1_MOUSE Hippocalcin-like protein 1 E9Q6H8_MOUSE Protein Plekha5 TAF5_MOUSE Transcription initiation factor TFIID subunit 5 CANT1_MOUSE Soluble calcium-activated nucleotidase 1 CSTF1_MOUSE Cleavage stimulation factor subunit 1 CTL1_MOUSE Choline transporter-like protein 1 COMD6_MOUSE COMM domain-containing protein 6 GPKOW_MOUSE G patch domain and KOW motifs-containing protein U119B_MOUSE Protein unc-119 homolog B EMAL2_MOUSE Echinoderm microtubule-associated protein-like 2 G45IP_MOUSE Growth arrest and DNA damage-inducible proteins-interacting protein 1 TLL2_MOUSE Tolloid-like protein 2 VPS52_MOUSE Vacuolar protein sorting-associated protein 52 homolog XRN2_MOUSE 5'-3' exoribonuclease 2 CDKL3_MOUSE Cyclin-dependent kinase-like 3 MTRR_MOUSE Methionine synthase reductase EXOS5_MOUSE Exosome complex component RRP46 CDS2_MOUSE Phosphatidate cytidylyltransferase 2 RBM40_MOUSE RNA-binding protein 40 BI1_MOUSE Bax inhibitor 1 RPC3_MOUSE DNA-directed RNA polymerase III subunit RPC3 TPC10_MOUSE Trafficking protein particle complex subunit 10 TLR3_MOUSE Toll-like receptor 3 FMR1_MOUSE Isoform ISO10 of Fragile X mental retardation protein 1 homolog FKB14_MOUSE Peptidyl-prolyl cis-trans isomerase FKBP14 GGPPS_MOUSE Geranylgeranyl pyrophosphate synthase WIZ_MOUSE Protein Wiz GDAP2_MOUSE Ganglioside-induced differentiation-associated protein 2 RFOX3_MOUSE RNA binding protein fox-1 homolog 3 E9Q4Z2_MOUSE Protein Acacb RT63_MOUSE Ribosomal protein 63, mitochondrial CIAO1_MOUSE Probable cytosolic iron-sulfur protein assembly protein CIAO1 THTPA_MOUSE Thiamine-triphosphatase U2AF1_MOUSE Splicing factor U2AF 35 kDa subunit HSC20_MOUSE Iron-sulfur cluster co-chaperone protein HscB, mitochondrial LUZP1_MOUSE Leucine zipper protein 1 RT35_MOUSE 28S ribosomal protein S35, mitochondrial ASCC1_MOUSE Activating signal cointegrator 1 complex subunit 1 GBG2_MOUSE Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 WRIP1_MOUSE ATPase WRNIP1 ARRB1_MOUSE Beta-arrestin-1 DNM3A_MOUSE DNA (cytosine-5)-methyltransferase 3A INT9_MOUSE Integrator complex subunit 9 TIP_MOUSE T-cell immunomodulatory protein
EP
Tdrd3 Llph Rpl18a Ctc1 Sirpa Rnf123 Grem1 Tmem65 Gid4 Limd1 Gpn1 Naa25 Ptpn2 Fdx1l Nup37 Aldoart2 Tm7sf3 Prpf39 Hpcal1 Plekha5 Taf5 Cant1 Cstf1 Slc44a1 Commd6 Gpkow Unc119b Eml2 Gadd45gip1 Tll2 Vps52 Xrn2 Cdkl3 Mtrr Exosc5 Cds2 Rnpc3 Tmbim6 Polr3c Trappc10 Tlr3 Fmr1 Fkbp14 Ggps1 Wiz Gdap2 Rbfox3 Acacb Mrpl57 Ciao1 Thtpa U2af1 Hscb Luzp1 Mrps35 Ascc1 Gng2 Wrnip1 Arrb1 Dnmt3a Ints9 Itfg1
AC C
sp|Q91W18|TDRD3_MOUSE sp|Q9D945|LLPH_MOUSE sp|P62717|RL18A_MOUSE sp|Q5SUQ9|CTC1_MOUSE tr|A2ANC1|A2ANC1_MOUSE sp|Q5XPI3|RN123_MOUSE sp|O70326|GREM1_MOUSE sp|Q4VAE3|TMM65_MOUSE sp|Q9CPY6|GID4_MOUSE sp|Q9QXD8|LIMD1_MOUSE sp|Q8VCE2|GPN1_MOUSE sp|Q8BWZ3|NAA25_MOUSE sp|Q06180|PTN2_MOUSE sp|Q9CPW2|ADXL_MOUSE sp|Q9CWU9|NUP37_MOUSE tr|A6ZI47|A6ZI47_MOUSE sp|Q9CRG1|TM7S3_MOUSE sp|Q8K2Z2|PRP39_MOUSE sp|P62748|HPCL1_MOUSE tr|E9Q6H8|E9Q6H8_MOUSE sp|Q8C092|TAF5_MOUSE sp|Q8VCF1|CANT1_MOUSE sp|Q99LC2|CSTF1_MOUSE sp|Q6X893|CTL1_MOUSE sp|Q3V4B5|COMD6_MOUSE sp|Q56A08|GPKOW_MOUSE sp|Q8C4B4|U119B_MOUSE sp|Q7TNG5|EMAL2_MOUSE sp|Q9CR59|G45IP_MOUSE sp|Q9WVM6|TLL2_MOUSE sp|Q8C754|VPS52_MOUSE sp|Q9DBR1|XRN2_MOUSE sp|Q8BLF2|CDKL3_MOUSE sp|Q8C1A3|MTRR_MOUSE sp|Q9CRA8|EXOS5_MOUSE sp|Q99L43|CDS2_MOUSE sp|Q3UZ01|RBM40_MOUSE sp|Q9D2C7|BI1_MOUSE sp|Q9D483|RPC3_MOUSE sp|Q3TLI0|TPC10_MOUSE sp|Q99MB1|TLR3_MOUSE sp|P35922-10|FMR1_MOUSE sp|P59024|FKB14_MOUSE sp|Q9WTN0|GGPPS_MOUSE sp|O88286|WIZ_MOUSE sp|Q9DBL2|GDAP2_MOUSE sp|Q8BIF2|RFOX3_MOUSE tr|E9Q4Z2|E9Q4Z2_MOUSE sp|Q9CQF8|RT63_MOUSE sp|Q99KN2|CIAO1_MOUSE sp|Q8JZL3|THTPA_MOUSE sp|Q9D883|U2AF1_MOUSE sp|Q8K3A0|HSC20_MOUSE sp|Q8R4U7|LUZP1_MOUSE sp|Q8BJZ4|RT35_MOUSE sp|Q9D8Z1|ASCC1_MOUSE sp|P63213|GBG2_MOUSE sp|Q91XU0|WRIP1_MOUSE sp|Q8BWG8|ARRB1_MOUSE sp|O88508|DNM3A_MOUSE sp|Q8K114|INT9_MOUSE sp|Q99KW9|TIP_MOUSE
19.8076 51.3599 93.3872 70.0954 83.3318 88.453 70.7447 38.012 35.5843 28.0364 50.9638 29.7144 25.3643 25.2926 71.2257 58.8611 95.9424 49.6628 24.5655 56.0959 68.6225 58.3655 15.7357 26.2354 31.3184 49.4963 19.5127 62.9079 66.1694 41.6158 71.9888 25.47 48.9885 57.401 66.4443 71.348 24.6854 42.5993 17.8716 41.5389 47.1893 31.5838 83.738 62.4155 46.1274 43.0169 29.6705 29.1382 68.9544 25.5603 61.9716 12.8069 35.2294 41.5798 38.2078 65.3256 40.5354 26.944 41.1588 23.9709 80.388 36.587
19.5546 36.9515 47.1651 80.4491 7.72037 55.6471 113.412 46.5349 31.3418 110.145 48.1066 30.5973 43.5636 13.2832 108.162 111.782 32.9464 59.7201 30.5641 46.7422 67.3804 40.1788 53.6128 14.9867 42.5869 166.425 154.573 91.8816 34.7261 29.7876 32.0733 24.8583 37.0299 65.4006 85.2033 61.0269 14.293 80.0469 21.9512 68.9665 48.287 30.6521 48.8361 53.8999 55.7861 71.2117 40.9488 36.331 40.2034 68.2863 45.5845 86.827 28.418 40.3208 29.6454 63.2153 51.5899 22.8152 38.4574 16.0168 107.339 41.6533
37.4478 98.8619 41.7878 85.0723 12.0052 45.5805 87.1451 51.8644 36.2068 283.586 48.9381 24.1342 41.0647 54.0712 100.141 112.279 42.7048 40.9789 55.4607 102.49 38.2974 30.5464 58.6997 7.4731 106.31 324.446 72.2531 85.5482 78.6939 48.1679 44.599 18.1007 38.3535 81.6554 71.8195 50.9941 33.7486 69.7889 11.7064 56.3273 26.4995 44.084 118.49 81.2597 75.2973 105.883 87.416 29.21 99.722 142.251 99.5568 133.16 67.6357 108.496 73.3036 81.3414 58.4955 15.0282 33.2688 14.9201 117.426 35.3178
1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.06 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.05 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.04 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03 1.03
1.30 1.45 0.69 1.26 0.11 0.73 1.23 1.37 1.10 6.15 0.82 0.84 1.38 1.10 1.35 1.92 0.47 0.99 1.46 1.21 0.68 0.56 3.02 0.35 2.36 4.38 4.81 1.26 0.76 0.71 0.63 0.64 0.75 1.35 1.04 0.89 0.88 1.74 0.82 1.42 0.94 0.94 0.94 1.04 1.10 1.84 2.01 0.94 0.91 3.71 1.02 9.91 1.31 1.71 1.28 1.05 1.36 0.68 0.91 0.62 1.23 1.05
ACCEPTED MANUSCRIPT
TE D
56.6389 33.9206 45.7245 49.7757 34.6656 60.5144 29.1569 80.7973 24.6885 79.5891 83.4663 57.6984 51.3602 99.3534 39.167 42.718 25.8664 73.5275 42.0859 47.7643 44.8655 22.552 38.5141 49.3118 19.9142 47.3467 56.207 81.2824 26.5784 33.9935 106.132 51.0424 37.543 67.6235 78.695 26.23 54.681 41.5922 39.1407 36.3923 87.4371 51.4318 39.6571 9.91263 17.6189 47.7002 26.8368 149.773 75.6729 164.14 109.623 35.723 35.262 80.6917 21.6726 46.1123 53.6221 49.7879 30.9715 50.9652 19.3661 34.7362
55.9003 45.4857 50.7666 57.8058 40.0475 64.1075 37.7046 36.745 22.3168 90.23 83.5931 65.7448 46.2593 98.4074 31.5338 47.1657 30.7057 77.6201 39.3007 62.5267 35.6929 17.5507 42.5691 68.0347 20.6303 47.7276 69.012 80.5377 26.4265 32.9396 92.6494 52.1049 40.9941 75.9374 77.3311 27.1383 57.6523 44.8108 52.5547 27.0023 51.6842 60.6219 41.5181 14.946 24.4031 51.2343 30.6508 163.843 91.9444 144.299 119.907 41.9614 26.4356 92.0734 31.0371 48.0588 54.2265 46.8559 41.6228 46.992 23.7242 41.5131
RI PT
58.4847 43.7572 45.4359 56.473 30.5746 55.4453 42.617 30.1267 18.9903 85.898 92.1614 59.2845 52.3024 92.1688 23.9965 34.9449 26.1498 65.7145 36.1443 55.181 47.887 13.3904 39.1044 62.2578 18.5404 43.1498 64.7808 79.5679 25.4921 31.6238 118.935 54.3664 39.8145 67.1002 72.5068 24.1578 60.7017 38.7265 49.1965 43.1744 62.797 55.7943 42.3911 15.2848 25.9228 52.753 33.0546 137.014 86.2954 131.257 139.438 41.648 21.8813 83.0248 32.4086 43.7046 56.8645 42.217 41.5862 48.0857 21.3986 34.5513
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
COMD2_MOUSE COMM domain-containing protein 2 Q9JHF5_MOUSE A3 subunit of vacuolar-adenosine triphosphatase NT5M_MOUSE 5'(3')-deoxyribonucleotidase, mitochondrial MMP14_MOUSE Matrix metalloproteinase-14 MED4_MOUSE Mediator of RNA polymerase II transcription subunit 4 BCL10_MOUSE B-cell lymphoma/leukemia 10 LIPT_MOUSE Lipoyltransferase 1, mitochondrial CDN1A_MOUSE Cyclin-dependent kinase inhibitor 1 E2F5_MOUSE Transcription factor E2F5 SMYD2_MOUSE N-lysine methyltransferase SMYD2 APC7_MOUSE Anaphase-promoting complex subunit 7 LAS1L_MOUSE Ribosomal biogenesis protein LAS1L SUN1_MOUSE SUN domain-containing protein 1 PX11B_MOUSE Peroxisomal membrane protein 11B ENC1_MOUSE Ectoderm-neural cortex protein 1 DEUP1_MOUSE Deuterosome protein 1 Q810Y9_MOUSE PRAMEl6 AVEN_MOUSE Cell death regulator Aven CETN2_MOUSE Centrin-2 F6UFZ5_MOUSE Protein Pcf11 (Fragment) TBCK_MOUSE TBC domain-containing protein kinase-like protein G3UW66_MOUSE MCG120086 EXOS8_MOUSE Exosome complex component RRP43 ACY2_MOUSE Aspartoacylase UBAP2_MOUSE Ubiquitin-associated protein 2 Q91XX1_MOUSE Protein Pcdhgb6 RN135_MOUSE E3 ubiquitin-protein ligase RNF135 QSOX1_MOUSE Sulfhydryl oxidase 1 ATG4B_MOUSE Cysteine protease ATG4B ISOC1_MOUSE Isochorismatase domain-containing protein 1 S12A2_MOUSE Solute carrier family 12 member 2 OXLD1_MOUSE Oxidoreductase-like domain-containing protein 1 NCOA2_MOUSE Nuclear receptor coactivator 2 RT18B_MOUSE 28S ribosomal protein S18b, mitochondrial MLX_MOUSE Max-like protein X SIKE1_MOUSE Suppressor of IKBKE 1 FBX6_MOUSE F-box only protein 6 ANM3_MOUSE Protein arginine N-methyltransferase 3 TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 TEP1_MOUSE Telomerase protein component 1 TTC9C_MOUSE Tetratricopeptide repeat protein 9C NRK1_MOUSE Nicotinamide riboside kinase 1 SUSD3_MOUSE Sushi domain-containing protein 3 AFAD_MOUSE Afadin HAIR_MOUSE Lysine-specific demethylase hairless E9Q4X2_MOUSE Protein Uggt2 UCK2_MOUSE Uridine-cytidine kinase 2 LRP1B_MOUSE Low-density lipoprotein receptor-related protein 1B VAV2_MOUSE Guanine nucleotide exchange factor VAV2 PDRG1_MOUSE p53 and DNA damage-regulated protein 1 YTDC1_MOUSE YTH domain-containing protein 1 CEBPB_MOUSE CCAAT/enhancer-binding protein beta G3UYT1_MOUSE Protein Skiv2l (Fragment) UEVLD_MOUSE Ubiquitin-conjugating enzyme E2 variant 3 C19L2_MOUSE CWF19-like protein 2 KSR1_MOUSE Kinase suppressor of Ras 1 RAB43_MOUSE Ras-related protein Rab-43 TAF7_MOUSE Transcription initiation factor TFIID subunit 7 MARF1_MOUSE Meiosis arrest female protein 1 PHKG1_MOUSE Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform F6ZQA3_MOUSE Protein Numa1 (Fragment) PGAM5_MOUSE Serine/threonine-protein phosphatase PGAM5, mitochondrial
EP
Commd2 Tcirg1 Nt5m Mmp14 Med4 Bcl10 Lipt1 Cdkn1a E2f5 Smyd2 Anapc7 Las1l Sun1 Pex11b Enc1 Ccdc67 Pramel6 Aven Cetn2 Pcf11 Tbck Gm6505 Exosc8 Aspa Ubap2 Pcdhgc3 Rnf135 Qsox1 Atg4b Isoc1 Slc12a2 Oxld1 Ncoa2 Mrps18b Mlx Sike1 Fbxo6 Prmt3 Trpm8 Tep1 Ttc9c Nmrk1 Susd3 Mllt4 Hr Uggt2 Uck2 Lrp1b Vav2 Pdrg1 Ythdc1 Cebpb Skiv2l Uevld Cwf19l2 Ksr1 Rab43 Taf7 Marf1 Phkg1 Numa1 Pgam5
AC C
sp|Q8BXC6|COMD2_MOUSE tr|Q9JHF5|Q9JHF5_MOUSE sp|Q8VCE6|NT5M_MOUSE sp|P53690|MMP14_MOUSE sp|Q9CQA5|MED4_MOUSE sp|Q9Z0H7|BCL10_MOUSE sp|Q8VCM4|LIPT_MOUSE sp|P39689|CDN1A_MOUSE sp|Q61502|E2F5_MOUSE sp|Q8R5A0|SMYD2_MOUSE sp|Q9WVM3|APC7_MOUSE sp|A2BE28|LAS1L_MOUSE sp|Q9D666|SUN1_MOUSE sp|Q9Z210|PX11B_MOUSE sp|O35709|ENC1_MOUSE sp|Q7M6Y5|DEUP1_MOUSE tr|Q810Y9|Q810Y9_MOUSE sp|Q9D9K3|AVEN_MOUSE sp|Q9R1K9|CETN2_MOUSE tr|F6UFZ5|F6UFZ5_MOUSE sp|Q8BM85|TBCK_MOUSE tr|G3UW66|G3UW66_MOUSE sp|Q9D753|EXOS8_MOUSE sp|Q8R3P0|ACY2_MOUSE sp|Q91VX2|UBAP2_MOUSE tr|Q91XX1|Q91XX1_MOUSE sp|Q9CWS1|RN135_MOUSE sp|Q8BND5|QSOX1_MOUSE sp|Q8BGE6|ATG4B_MOUSE sp|Q91V64|ISOC1_MOUSE sp|P55012|S12A2_MOUSE sp|Q9CR10|OXLD1_MOUSE sp|Q61026|NCOA2_MOUSE sp|Q99N84|RT18B_MOUSE sp|O08609|MLX_MOUSE sp|Q9CPR7|SIKE1_MOUSE sp|Q9QZN4|FBX6_MOUSE sp|Q922H1|ANM3_MOUSE sp|Q8R4D5|TRPM8_MOUSE sp|P97499|TEP1_MOUSE sp|Q810A3|TTC9C_MOUSE sp|Q91W63|NRK1_MOUSE sp|Q9D176|SUSD3_MOUSE sp|Q9QZQ1|AFAD_MOUSE sp|Q61645|HAIR_MOUSE tr|E9Q4X2|E9Q4X2_MOUSE sp|Q99PM9|UCK2_MOUSE sp|Q9JI18|LRP1B_MOUSE sp|Q60992|VAV2_MOUSE sp|P59048|PDRG1_MOUSE sp|E9Q5K9|YTDC1_MOUSE sp|P28033|CEBPB_MOUSE tr|G3UYT1|G3UYT1_MOUSE sp|Q3U1V6|UEVLD_MOUSE sp|Q8BG79|C19L2_MOUSE sp|Q61097|KSR1_MOUSE sp|Q8CG50|RAB43_MOUSE sp|Q9R1C0|TAF7_MOUSE sp|Q8BJ34|MARF1_MOUSE sp|P07934|PHKG1_MOUSE tr|F6ZQA3|F6ZQA3_MOUSE sp|Q8BX10|PGAM5_MOUSE
62.472 34.2672 42.7863 50.823 26.6402 54.4164 35.6335 76.5817 22.2845 78.5528 95.3165 53.3094 59.1991 96.3764 32.6991 31.8029 22.1689 63.8159 40.1142 41.9425 58.4198 18.9069 36.1613 45.0133 18.3071 43.8795 53.3836 82.1633 26.2211 33.3612 134.619 54.3279 37.1091 60.0683 75.2647 23.5301 58.3493 35.9258 36.1727 52.9003 99.1361 46.9284 40.7454 10.3149 19.2173 49.3928 29.3414 123.314 70.1712 151.331 129.114 35.3956 30.6573 71.486 22.9039 41.5185 55.8199 44.7701 30.5984 51.4461 16.7663 27.1515
47.0653 75.2975 52.3868 55.1285 31.6803 44.5797 17.7002 19.2255 13.7108 81.9249 68.6812 65.7154 142.336 117.191 81.6121 15.4974 24.773 37.8774 19.836 29.63 65.4213 9.28917 32.785 45.9342 7.43033 20.6574 41.4543 54.5008 25.1853 27.3664 99.3332 48.7504 36.4956 16.8144 64.877 16.4825 37.2007 65.7703 30.6221 30.1058 72.5266 95.7115 34.049 30.4042 5.81756 56.7117 23.5025 149.761 68.7917 123.97 96.933 130.117 44.4964 84.1565 41.4346 93.2009 79.7286 40.7803 38.4229 15.6295 15.7913 31.2426
52.0032 50.2402 78.7344 72.1029 47.1151 81.9922 41.9101 60.722 31.7818 80.5223 91.0557 36.556 42.2513 65.2635 57.043 39.49 45.9839 113.363 65.1106 95.513 74.5159 27.5322 36.4194 66.8782 32.1283 46.8735 85.7397 72.3403 25.4616 21.1972 84.8569 114.632 81.9842 81.7094 87.7193 35.7758 41.7602 51.2611 36.6935 42.7344 77.086 135.94 62.3884 44.5814 0 38.227 28.4074 239.143 133.44 291.051 79.39 79.6948 40.8334 105.979 34.2809 111.089 41.2207 84.3553 58.3412 15.0978 23.1389 21.6815
1.03 1.03 1.03 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.02 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.01 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.99 0.99 0.99
0.86 1.62 1.44 1.20 1.21 1.09 0.83 0.72 1.04 0.98 0.91 0.87 1.78 0.95 2.20 0.71 1.36 1.09 1.09 1.22 1.51 1.02 0.89 1.01 1.03 0.75 1.05 0.79 0.97 0.74 0.82 1.55 1.53 0.73 1.01 1.04 0.68 1.46 0.76 0.92 1.00 2.16 1.18 2.98 0.13 0.95 0.87 1.36 1.25 1.40 0.71 2.71 1.49 1.16 1.40 2.27 1.09 1.36 1.33 0.31 0.95 0.76
ACCEPTED MANUSCRIPT
M AN U
TE D
70.4807 40.0658 66.6061 139.028 28.4728 41.3594 22.0794 66.3092 42.6407 46.1592 64.9603 65.3241 40.1658 42.5928 29.8371 32.3292 39.0839 52.3927 55.7015 42.3828 45.9952 66.9751 53.8537 36.1021 117.221 41.7688 40.3449 54.8424 52.665 76.4833 37.4879 57.6632 71.3866 45.3683 45.2935 20.471 68.565 80.9823 63.7112 24.5097 8.57996 107.493 40.6417 14.2575 64.2335 50.1761 23.7707 46.3133 52.3728 89.0624 33.0436 51.8934 65.4468 159.688 26.1689 57.3798 37.5195 55.8115 57.7992 36.1507 47.8515 78.1989
77.9748 50.2753 63.4539 140.601 34.0486 41.1434 22.6042 64.973 44.8053 53.6842 75.3297 64.2056 48.9753 56.4237 18.1474 33.1695 34.2124 53.2359 41.3971 39.8383 39.3185 76.8687 56.6495 32.9852 128.103 38.9855 30.8105 54.0495 67.6023 72.36 36.1344 67.6006 53.2894 40.0822 36.0739 23.0428 76.6386 71.8617 77.7089 31.1192 12.5688 128.412 39.5035 22.0169 58.3045 47.1979 19.6073 50.0712 57.7111 85.4042 30.7244 62.049 71.7561 145.095 28.5121 62.4525 34.1989 56.8239 55.7378 39.7071 43.9058 79.779
RI PT
93.1753 48.4437 67.3264 132.037 38.2603 46.2895 20.6821 57.6891 38.7934 46.793 75.3893 64.0952 45.9663 51.2926 30.6617 33.9237 42.3159 48.9292 49.8649 36.6993 51.8027 73.3902 51.9969 35.1139 152.876 40.4782 32.7833 52.8566 64.8133 64.4245 34.0311 71.2888 66.0906 49.0914 32.267 24.8329 80.8581 61.0301 67.5914 33.6291 13.1809 118.089 34.4178 20.3368 55.9733 50.2008 20.6108 53.8526 47.82 79.2433 41.2082 71.2422 63.1517 132.859 33.7553 60.5346 32.1921 73.4203 63.0058 44.5784 48.4244 74.429
SC
FIBP_MOUSE Acidic fibroblast growth factor intracellular-binding protein 1 TAOK1_MOUSE Serine/threonine-protein kinase TAO1 1 ANM7_MOUSE Protein arginine N-methyltransferase 7 1 F195B_MOUSE Protein FAM195B 1 GPTC4_MOUSE G patch domain-containing protein 4 1 PM34_MOUSE Peroxisomal membrane protein PMP34 1 PELP1_MOUSE Proline-, glutamic acid- and leucine-rich protein 1 1 G3UWM2_MOUSE Protein Snx21 1 TOLIP_MOUSE Toll-interacting protein 1 KAD4_MOUSE Adenylate kinase 4, mitochondrial 1 CDK13_MOUSE Cyclin-dependent kinase 13 1 ABCBA_MOUSE ATP-binding cassette sub-family B member 10, mitochondrial 1 MOD5_MOUSE tRNA dimethylallyltransferase, mitochondrial 1 EGFR_MOUSE Epidermal growth factor receptor 1 INT7_MOUSE Integrator complex subunit 7 1 MB12A_MOUSE Multivesicular body subunit 12A 1 FUND1_MOUSE FUN14 domain-containing protein 1 1 RRP15_MOUSE RRP15-like protein 1 MSMO1_MOUSE Methylsterol monooxygenase 1 1 Q80ZX0_MOUSE Protein Sec24b 1 MED25_MOUSE Mediator of RNA polymerase II transcription subunit 25 1 PUS10_MOUSE Putative tRNA pseudouridine synthase Pus10 1 KPB1_MOUSE Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform 1 SNAPN_MOUSE SNARE-associated protein Snapin 1 WDR47_MOUSE WD repeat-containing protein 47 1 GPX41_MOUSE Phospholipid hydroperoxide glutathione peroxidase, mitochondrial 1 GSE1_MOUSE Genetic suppressor element 1 1 STMN1_MOUSE Stathmin 1 CNST_MOUSE Consortin 1 PPIL3_MOUSE Peptidyl-prolyl cis-trans isomerase-like 3 1 CCD43_MOUSE Coiled-coil domain-containing protein 43 1 E9QAB6_MOUSE Protein Ptar1 1 CO7A1_MOUSE Collagen alpha-1(VII) chain 1 C56D2_MOUSE Cytochrome b561 domain-containing protein 2 1 KRI1_MOUSE Protein KRI1 homolog 1 DLG2_MOUSE Disks large homolog 2 1 OSGEP_MOUSE Probable tRNA N6-adenosine threonylcarbamoyltransferase 1 MF2NB_MOUSE Protein MEF2BNB 1 TE2IP_MOUSE Telomeric repeat-binding factor 2-interacting protein 1 1 FUCO2_MOUSE Plasma alpha-L-fucosidase 1 MEP50_MOUSE Methylosome protein 50 1 DCAF7_MOUSE DDB1- and CUL4-associated factor 7 1 COA5_MOUSE Cytochrome c oxidase assembly factor 5 1 MILK1_MOUSE MICAL-like protein 1 1 UBL5_MOUSE Ubiquitin-like protein 5 1 SMRD2_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily 1 D member 2 VP37B_MOUSE Vacuolar protein sorting-associated protein 37B 1 DPH5_MOUSE Diphthine synthase 1 GBG5_MOUSE Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 1 SMCA2_MOUSE Probable global transcription activator SNF2L2 1 P2RX4_MOUSE P2X purinoceptor 4 1 TFDP1_MOUSE Transcription factor Dp-1 1 SCRIB_MOUSE Protein scribble homolog 1 PFD1_MOUSE Prefoldin subunit 1 1 Q9DAV6_MOUSE Protein Serpinb9b 1 EXOS1_MOUSE Exosome complex component CSL4 1 RWDD4_MOUSE RWD domain-containing protein 4 1 PRPK_MOUSE TP53-regulating kinase 1 RGS2_MOUSE Regulator of G-protein signaling 2 1 BTD_MOUSE Biotinidase 1 D3Z175_MOUSE MCG142459 1 TTC4_MOUSE Tetratricopeptide repeat protein 4 1
EP
Fibp Taok1 Prmt7 Fam195b Gpatch4 Slc25a17 Pelp1 Snx21 Tollip Ak4 Cdk13 Abcb10 Trit1 Egfr Ints7 Mvb12a Fundc1 Rrp15 Msmo1 Sec24b Med25 Pus10 Phka1 Snapin Wdr47 Gpx4 Gse1 Stmn1 Cnst Ppil3 Ccdc43 Ptar1 Col7a1 Cyb561d2 Kri1 Dlg2 Osgep Mef2bnb Terf2ip Fuca2 Wdr77 Dcaf7 Coa5 Micall1 Ubl5 Smarcd2 Vps37b Dph5 Gng5 Smarca2 P2rx4 Tfdp1 Scrib Pfdn1 Serpinb9b Exosc1 Rwdd4 Tp53rk Rgs2 Btd Gm5519 Ttc4
AC C
sp|Q9JI19|FIBP_MOUSE sp|Q5F2E8|TAOK1_MOUSE sp|Q922X9|ANM7_MOUSE sp|Q3UGS4|F195B_MOUSE sp|Q3TFK5|GPTC4_MOUSE sp|O70579|PM34_MOUSE sp|Q9DBD5|PELP1_MOUSE tr|G3UWM2|G3UWM2_MOUSE sp|Q9QZ06|TOLIP_MOUSE sp|Q9WUR9|KAD4_MOUSE sp|Q69ZA1|CDK13_MOUSE sp|Q9JI39|ABCBA_MOUSE sp|Q80UN9|MOD5_MOUSE sp|Q01279|EGFR_MOUSE sp|Q7TQK1|INT7_MOUSE sp|Q78HU3|MB12A_MOUSE sp|Q9DB70|FUND1_MOUSE sp|Q9CYX7|RRP15_MOUSE sp|Q9CRA4|MSMO1_MOUSE tr|Q80ZX0|Q80ZX0_MOUSE sp|Q8VCB2|MED25_MOUSE sp|Q9D3U0|PUS10_MOUSE sp|P18826|KPB1_MOUSE sp|Q9Z266|SNAPN_MOUSE sp|Q8CGF6|WDR47_MOUSE sp|O70325|GPX41_MOUSE sp|Q3U3C9|GSE1_MOUSE sp|P54227|STMN1_MOUSE sp|Q8CBC4|CNST_MOUSE sp|Q9D6L8|PPIL3_MOUSE sp|Q9CR29|CCD43_MOUSE tr|E9QAB6|E9QAB6_MOUSE sp|Q63870|CO7A1_MOUSE sp|Q9WUE3|C56D2_MOUSE sp|Q8VDQ9|KRI1_MOUSE sp|Q91XM9|DLG2_MOUSE sp|Q8BWU5|OSGEP_MOUSE sp|Q9D6Y4|MF2NB_MOUSE sp|Q91VL8|TE2IP_MOUSE sp|Q99KR8|FUCO2_MOUSE sp|Q99J09|MEP50_MOUSE sp|P61963|DCAF7_MOUSE sp|Q99M07|COA5_MOUSE sp|Q8BGT6|MILK1_MOUSE sp|Q9EPV8|UBL5_MOUSE sp|Q99JR8|SMRD2_MOUSE sp|Q8R0J7|VP37B_MOUSE sp|Q9CWQ0|DPH5_MOUSE sp|Q80SZ7|GBG5_MOUSE sp|Q6DIC0|SMCA2_MOUSE sp|Q9JJX6|P2RX4_MOUSE sp|Q08639|TFDP1_MOUSE sp|Q80U72|SCRIB_MOUSE sp|Q9CWM4|PFD1_MOUSE tr|Q9DAV6|Q9DAV6_MOUSE sp|Q9DAA6|EXOS1_MOUSE sp|Q9CPR1|RWDD4_MOUSE sp|Q99PW4|PRPK_MOUSE sp|O08849|RGS2_MOUSE sp|Q8CIF4|BTD_MOUSE tr|D3Z175|D3Z175_MOUSE sp|Q8R3H9|TTC4_MOUSE
83.9864 37.2615 68.9312 127.154 31.8534 45.35 19.5894 57.2906 35.4496 37.9219 62.9864 63.3032 35.8097 35.9726 41.3847 31.9145 45.6457 45.9792 61.7999 37.401 56.1439 60.0738 46.4939 36.3917 134.757 41.0348 40.2263 50.4353 46.095 63.9029 32.984 56.9959 79.4722 51.1367 38.8198 20.6919 67.6033 65.2168 49.0248 24.9718 8.39313 88.8059 32.7385 11.2732 57.3264 49.2909 23.0504 45.9818 38.2312 75.7343 40.2768 55.6765 51.1822 134.506 28.7191 50.0944 32.3278 66.2642 59.273 37.0647 47.6349 65.2776
80.5218 39.3014 71.0779 91.3146 22.5184 54.5799 21.2038 16.4654 35.3706 47.126 34.63 44.2371 57.2285 38.4079 44.8306 40.9392 27.7497 35.9802 21.6271 54.5702 38.0298 92.6058 22.1133 25.1036 129.369 32.752 34.8819 55.1666 48.2763 46.6505 28.8122 78.6148 52.7805 30.6266 16.6905 23.5651 63.407 45.7061 41.8134 21.5842 102.773 93.3928 19.5887 82.4311 54.4414 52.2303 19.5316 49.5135 36.3585 49.7533 27.9658 57.3478 91.4035 127.331 92.8716 72.5581 19.7586 61.1894 24.1954 9.64209 46.3376 65.7195
69.8845 46.1075 64.7974 208.84 31.7845 53.4685 32.5542 46.3926 53.3509 79.0859 61.8391 50.6309 54.9192 39.9381 42.5856 46.286 42.0183 57.3486 19.0431 41.5689 73.3447 97.0902 31.3262 58.065 136.496 68.266 119.844 53.2987 99.9865 120.466 42.5025 73.4063 70.4106 28.5119 38.9703 23.4588 51.0396 102.447 109.475 39.4648 190.001 179.584 51.0101 214.506 123.055 50.4381 33.1975 52.6623 45.9604 111.584 27.3717 93.2189 63.6845 285.096 66.9514 66.4215 63.7815 39.7173 79.0699 31.8494 61.207 157.552
0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.99 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.98 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.97 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.96 0.95 0.95 0.95 0.95 0.95 0.95 0.95
0.92 0.96 1.01 1.11 0.81 1.23 1.26 0.51 1.09 1.36 0.69 0.73 1.30 0.83 1.44 1.32 0.86 0.92 0.39 1.22 1.14 1.35 0.50 1.17 0.98 1.23 2.12 1.01 1.26 1.19 1.00 1.18 0.90 0.63 0.72 1.04 0.77 1.04 1.15 1.05 13.45 1.21 0.94 8.58 1.48 1.02 1.19 1.02 0.82 0.96 0.75 1.22 1.21 1.41 2.67 1.18 1.20 0.78 0.85 0.51 1.12 1.46
ACCEPTED MANUSCRIPT
TE D
28.2458 83.5649 45.1324 38.9236 49.0616 27.7228 38.515 95.2379 26.3498 77.7603 50.1175 87.8552 59.6281 81.4096 88.9452 42.188 64.5457 47.2917 67.5585 42.5854 31.4857 59.8641 87.2546 35.3543 34.0808 90.9161 46.2909 69.0016 12.0015 119.681 21.0017 73.0743 48.3177 30.7245 87.6258 44.0994 168.441 34.9438 86.2719 49.3331 261.402 69.6736 86.0814 32.8033 152.694 50.503 51.8211 52.931 28.0771 126.814 85.4267 43.9099 30.9198 22.707 71.214 38.7078 53.453 75.2865 43.7123 58.9384 33.1571 97.8593
33.6637 83.0315 59.8408 33.8416 62.386 26.3693 33.6567 119.995 25.5286 77.5123 61.8493 78.1151 66.3099 94.6997 77.7439 47.4857 81.2157 43.8428 72.9087 54.4761 29.84 35.6867 95.4451 36.4296 35.0716 100.758 40.118 52.2171 22.939 135.186 18.9617 70.6171 26.84 30.1302 88.6194 45.1427 124.623 42.9926 44.2321 57.3558 249.863 61.7487 81.1738 30.2338 175.115 40.4022 55.087 59.3675 32.7078 109.526 85.8984 44.3479 28.7131 20.6393 74.7454 29.9756 47.9858 63.2155 34.5942 55.0509 33.284 95.8406
RI PT
34.6892 73.4787 62.4465 34.5142 60.125 29.7541 27.7983 134.651 25.4404 81.6917 66.2699 98.4652 67.9246 91.5175 72.5904 45.5529 77.2835 37.8458 80.5714 50.9561 26.621 44.828 97.1621 30.9095 36.4791 93.9194 28.5942 50.2583 24.7494 139.18 17.4891 65.3669 29.9205 26.8938 90.809 48.8149 185.704 48.6369 65.3222 51.2664 248.303 69.2723 98.1848 34.5705 154.083 39.6502 68.9154 66.1275 36.8784 118.239 86.8312 44.4258 28.2996 5.56217 80.475 21.1897 48.2784 70.2622 52.0596 57.406 41.619 91.2239
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
MCM3_MOUSE DNA replication licensing factor MCM3 CC117_MOUSE Coiled-coil domain-containing protein 117 INGR1_MOUSE Interferon gamma receptor 1 PKHG5_MOUSE Pleckstrin homology domain-containing family G member 5 NLRX1_MOUSE NLR family member X1 FBX2_MOUSE F-box only protein 2 RBBP7_MOUSE Histone-binding protein RBBP7 PLCH1_MOUSE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 EDC3_MOUSE Enhancer of mRNA-decapping protein 3 EXTL2_MOUSE Exostosin-like 2 HDGR3_MOUSE Hepatoma-derived growth factor-related protein 3 PEX16_MOUSE Peroxisomal membrane protein PEX16 S2535_MOUSE Solute carrier family 25 member 35 S4A4_MOUSE Electrogenic sodium bicarbonate cotransporter 1 CT2NL_MOUSE CTTNBP2 N-terminal-like protein CTDP1_MOUSE RNA polymerase II subunit A C-terminal domain phosphatase HTRA2_MOUSE Serine protease HTRA2, mitochondrial ZN330_MOUSE Zinc finger protein 330 MITD1_MOUSE MIT domain-containing protein 1 ANXA7_MOUSE Annexin A7 ZFYV1_MOUSE Zinc finger FYVE domain-containing protein 1 NOG2_MOUSE Nucleolar GTP-binding protein 2 HDAC6_MOUSE Histone deacetylase 6 BCL7A_MOUSE B-cell CLL/lymphoma 7 protein family member A FA50A_MOUSE Protein FAM50A CASC3_MOUSE Protein CASC3 E9Q6K3_MOUSE Protein Pibf1 EIF1A_MOUSE Probable RNA-binding protein EIF1AD NPHN_MOUSE Nephrin DUS2L_MOUSE tRNA-dihydrouridine(20) synthase [NAD(P)+]-like MAP1S_MOUSE Microtubule-associated protein 1S CGBP1_MOUSE CGG triplet repeat-binding protein 1 TIM23_MOUSE Mitochondrial import inner membrane translocase subunit Tim23 E9Q842_MOUSE Protein Nav2 NDUF5_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 WDR19_MOUSE WD repeat-containing protein 19 E0CX20_MOUSE Protein BUD31 homolog IGSF8_MOUSE Immunoglobulin superfamily member 8 RING2_MOUSE E3 ubiquitin-protein ligase RING2 B7FAU2_MOUSE Tafazzin (Fragment) Q3TIV9_MOUSE AP-1 complex subunit sigma-2 EGLN1_MOUSE Egl nine homolog 1 EDEM3_MOUSE ER degradation-enhancing alpha-mannosidase-like protein 3 XRCC4_MOUSE DNA repair protein XRCC4 AKTS1_MOUSE Proline-rich AKT1 substrate 1 N6MT2_MOUSE N(6)-adenine-specific DNA methyltransferase 2 SSBP2_MOUSE Single-stranded DNA-binding protein 2 MA7D2_MOUSE MAP7 domain-containing protein 2 CHSTC_MOUSE Carbohydrate sulfotransferase 12 TBA4A_MOUSE Tubulin alpha-4A chain LRP5_MOUSE Low-density lipoprotein receptor-related protein 5 TM10A_MOUSE tRNA methyltransferase 10 homolog A H7BWY8_MOUSE Pre-rRNA-processing protein TSR2 homolog TMOD2_MOUSE Tropomodulin-2 PPCS_MOUSE Phosphopantothenate--cysteine ligase TAB1_MOUSE TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TAF12_MOUSE Transcription initiation factor TFIID subunit 12 MIC1_MOUSE Uncharacterized protein C18orf8 homolog OGFD3_MOUSE 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 RIOK3_MOUSE Serine/threonine-protein kinase RIO3 GALK2_MOUSE N-acetylgalactosamine kinase MIER1_MOUSE Mesoderm induction early response protein 1
EP
Mcm3 Ccdc117 Ifngr1 Plekhg5 Nlrx1 Fbxo2 Rbbp7 Plch1 Edc3 Extl2 Hdgfrp3 Pex16 Slc25a35 Slc4a4 Cttnbp2nl Ctdp1 Htra2 Znf330 Mitd1 Anxa7 Zfyve1 Gnl2 Hdac6 Bcl7a Fam50a Casc3 Pibf1 Eif1ad Nphs1 Dus2 Map1s Cggbp1 Timm23 Nav2 Ndufaf5 Wdr19 Bud31 Igsf8 Rnf2 Taz Ap1s2 Egln1 Edem3 Xrcc4 Akt1s1 N6amt2 Ssbp2 Map7d2 Chst12 Tuba4a Lrp5 Trmt10a Tsr2 Tmod2 Ppcs Tab1 Taf12 Mic1 Ogfod3 Riok3 Galk2 Mier1
AC C
sp|P25206|MCM3_MOUSE sp|Q6PB51|CC117_MOUSE sp|P15261|INGR1_MOUSE sp|Q66T02|PKHG5_MOUSE sp|Q3TL44|NLRX1_MOUSE sp|Q80UW2|FBX2_MOUSE sp|Q60973|RBBP7_MOUSE sp|Q4KWH5|PLCH1_MOUSE sp|Q8K2D3|EDC3_MOUSE sp|Q9ES89|EXTL2_MOUSE sp|Q9JMG7|HDGR3_MOUSE sp|Q91XC9|PEX16_MOUSE sp|Q5SWT3|S2535_MOUSE sp|O88343|S4A4_MOUSE sp|Q99LJ0|CT2NL_MOUSE sp|Q7TSG2|CTDP1_MOUSE sp|Q9JIY5|HTRA2_MOUSE sp|Q922H9|ZN330_MOUSE sp|Q8VDV8|MITD1_MOUSE sp|Q07076|ANXA7_MOUSE sp|Q810J8|ZFYV1_MOUSE sp|Q99LH1|NOG2_MOUSE sp|Q9Z2V5|HDAC6_MOUSE sp|Q9CXE2|BCL7A_MOUSE sp|Q9WV03|FA50A_MOUSE sp|Q8K3W3|CASC3_MOUSE tr|E9Q6K3|E9Q6K3_MOUSE sp|Q3THJ3|EIF1A_MOUSE sp|Q9QZS7|NPHN_MOUSE sp|Q9D7B1|DUS2L_MOUSE sp|Q8C052|MAP1S_MOUSE sp|Q8BHG9|CGBP1_MOUSE sp|Q9WTQ8|TIM23_MOUSE tr|E9Q842|E9Q842_MOUSE sp|A2APY7|NDUF5_MOUSE sp|Q3UGF1|WDR19_MOUSE tr|E0CX20|E0CX20_MOUSE sp|Q8R366|IGSF8_MOUSE sp|Q9CQJ4|RING2_MOUSE tr|B7FAU2|B7FAU2_MOUSE tr|Q3TIV9|Q3TIV9_MOUSE sp|Q91YE3|EGLN1_MOUSE sp|Q2HXL6|EDEM3_MOUSE sp|Q924T3|XRCC4_MOUSE sp|Q9D1F4|AKTS1_MOUSE sp|Q9CY45|N6MT2_MOUSE sp|Q9CYZ8|SSBP2_MOUSE sp|A2AG50|MA7D2_MOUSE sp|Q99LL3|CHSTC_MOUSE sp|P68368|TBA4A_MOUSE sp|Q91VN0|LRP5_MOUSE sp|Q8C1Z8|TM10A_MOUSE tr|H7BWY8|H7BWY8_MOUSE sp|Q9JKK7|TMOD2_MOUSE sp|Q8VDG5|PPCS_MOUSE sp|Q8CF89|TAB1_MOUSE sp|Q8VE65|TAF12_MOUSE sp|Q8VC42|MIC1_MOUSE sp|Q9D136|OGFD3_MOUSE sp|Q9DBU3|RIOK3_MOUSE sp|Q68FH4|GALK2_MOUSE sp|Q5UAK0|MIER1_MOUSE
25.8759 65.3973 41.7868 35.4512 40.5414 27.7327 28.7297 96.1509 23.1276 72.2572 47.4478 96.7717 53.414 67.5836 73.7829 34.7688 51.5407 35.776 65.5721 32.9436 24.39 61.8027 76.2265 25.1776 30.4827 70.9171 29.364 58.3569 11.1249 104.603 16.5817 57.2119 45.2703 22.8589 75.2752 40.0288 199.965 33.6083 94.6674 34.7238 216.47 65.3157 87.267 31.2709 104.227 41.638 54.7744 48.9627 26.3716 113.252 70.6757 35.7268 24.9096 4.94894 62.3841 24.1425 43.9039 68.0235 51.7575 49.7465 34.0378 74.3223
28.4297 184.067 27.1551 23.9758 25.6658 24.019 24.3971 124.978 28.3598 76.8605 41.2322 100.219 74.4939 108.554 63.9028 44.2204 64.5394 36.2306 45.0626 36.6757 20.6941 38.6008 75.9598 24.8541 32.6623 77.1058 38.5845 35.7151 856.211 219.35 10.924 52.9175 45.8387 15.6851 58.778 71.3914 163.019 48.0477 34.8713 27.4893 147.309 73.9 58.4651 20.0733 133.246 28.2213 27.3373 21.282 12.5909 205.904 39.9922 17.264 26.189 42.4305 54.6668 49.2617 27.6793 71.7422 26.142 46.6335 52.408 76.7493
24.5418 359.401 25.1007 45.5058 32.0692 39.3588 43.752 82.6531 34.0735 105.842 75.1994 78.1455 115.437 75.6426 115.95 15.8044 91.9112 75.0401 40.2311 22.8552 31.7483 53.4417 46.5483 59.2605 36.3075 65.7532 278.176 110.651 583.077 292.544 24.7018 92.1686 49.2135 38.7927 131.561 31.9664 162.026 15.4519 67.5751 39.9626 311.11 128.059 55.1257 32.249 299.913 66.3166 58.3266 59.627 5.34237 302.482 52.2565 54.7055 40.5516 10.2427 57.1261 62.6528 55.4802 64.1111 37.2481 68.1604 39.2627 138.151
0.95 0.95 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.94 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.93 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.91 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.90
0.84 3.46 0.49 0.95 0.53 1.10 1.03 0.90 1.21 1.15 1.00 0.96 1.49 1.07 1.11 0.68 1.10 1.31 0.58 0.64 0.90 0.88 0.66 1.27 0.98 0.77 4.23 1.23 39.16 1.98 0.93 1.05 1.21 0.95 1.07 1.11 0.92 0.76 0.68 0.67 0.90 1.45 0.62 0.78 1.41 1.05 0.71 0.68 0.28 2.07 0.54 0.81 1.13 1.86 0.74 1.87 0.82 0.93 0.66 0.99 1.23 1.14
ACCEPTED MANUSCRIPT
Nwc Sssca1 Inip Ermp1 Alpl Wdr33 Secisbp2 Arpc4 Kif20b Morc3 Zfp952 Arfrp1 Ahnak2 Hint2 Aasdhppt
28.3943 40.3902 49.0305 22.6096 24.933 79.8821 46.4672 45.2032 109.691 39.0358 31.5549 35.7927 31.3604 59.6274 148.277 55.9945 40.2458 45.5227 88.6529 61.2827 62.5377 65.2549 14.2157 69.4198 34.3802 82.3087 147.726 57.0475 53.2467 37.7834 101.62 25.1712 108.443 58.3888 27.6402 156.752 34.0133 74.1339 16.5885 84.9561 27.2072 44.3065 32.578 143.938 44.1262 34.714 41.1384 37.9414 36.8918 88.8528 31.0465 11.8945 65.6069 23.4382 61.8964 46.138 45.1291 18.8237 43.5918 23.1689 36.7215 67.2868
29.8562 28.1099 40.7659 21.0887 27.5126 71.651 47.4559 27.5818 100.296 24.5882 27.0103 38.0271 37.4322 47.9231 150.448 49.6606 33.0112 46.1547 78.5814 52.9665 55.8648 64.7405 14.9199 73.2468 31.4403 49.1216 141.205 50.7994 42.4128 34.8093 89.3054 27.2766 104.62 57.3476 28.2888 138.426 38.9555 51.9198 17.4047 26.9145 22.1349 36.3048 30.8923 63.1571 56.5252 33.9248 40.3045 40.3063 35.3149 78.0402 23.6278 11.2415 55.1921 20.228 49.9594 27.0297 30.9822 12.7202 37.773 18.3477 30.1231 61.9382
TE D
M AN U
SC
RI PT
OSBL1_MOUSE Oxysterol-binding protein-related protein 1 1 34.3932 PIGT_MOUSE GPI transamidase component PIG-T 1 36.2941 F122A_MOUSE Protein FAM122A 1 36.0077 RIOK1_MOUSE Serine/threonine-protein kinase RIO1 1 21.1065 AXIN1_MOUSE Axin-1 1 29.2725 KLC2_MOUSE Kinesin light chain 2 1 78.5912 NR2CA_MOUSE Nuclear receptor 2C2-associated protein 1 56.289 SMYD5_MOUSE SET and MYND domain-containing protein 5 1 51.8664 PKNX1_MOUSE Homeobox protein PKNOX1 1 99.3799 PJA1_MOUSE E3 ubiquitin-protein ligase Praja-1 1 26.8789 NRF1_MOUSE Nuclear respiratory factor 1 1 28.5578 PPCEL_MOUSE Prolyl endopeptidase-like 1 41.0977 FA86A_MOUSE Protein FAM86A 1 46.4056 RPB11_MOUSE DNA-directed RNA polymerase II subunit RPB11 1 49.1332 COG6_MOUSE Conserved oligomeric Golgi complex subunit 6 1 146.407 RNF25_MOUSE E3 ubiquitin-protein ligase RNF25 1 44.3568 PHAR4_MOUSE Phosphatase and actin regulator 4 1 29.3126 L12R1_MOUSE Loss of heterozygosity 12 chromosomal region 1 protein homolog 1 43.688 CD033_MOUSE UPF0462 protein C4orf33 homolog 1 91.0531 GPR1_MOUSE G-protein coupled receptor 1 1 46.7244 SH3B4_MOUSE SH3 domain-binding protein 4 1 59.1919 UBIP1_MOUSE Upstream-binding protein 1 1 83.4844 NANP_MOUSE N-acylneuraminate-9-phosphatase 1 23.6892 PARVB_MOUSE Beta-parvin 1 75.1877 ENOG_MOUSE Gamma-enolase 1 32.0998 SMRCD_MOUSE SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily 1A containing DEAD/H 71.169 box 1 CLP1_MOUSE Polyribonucleotide 5'-hydroxyl-kinase Clp1 1 148.466 S2546_MOUSE Solute carrier family 25 member 46 1 68.0015 HOP2_MOUSE Homologous-pairing protein 2 homolog 1 39.1377 TPK1_MOUSE Thiamin pyrophosphokinase 1 1 40.6005 DTBP1_MOUSE Dysbindin 1 90.4282 ATX1L_MOUSE Ataxin-1-like 1 31.2396 RL22L_MOUSE 60S ribosomal protein L22-like 1 1 123.198 FOXO1_MOUSE Forkhead box protein O1 1 62.7542 TTC33_MOUSE Tetratricopeptide repeat protein 33 1 29.1053 BL1S5_MOUSE Biogenesis of lysosome-related organelles complex 1 subunit 5 1 136.019 KLF8_MOUSE Krueppel-like factor 8 1 42.0908 MK08_MOUSE Mitogen-activated protein kinase 8 1 61.4194 SCO1_MOUSE Protein SCO1 homolog, mitochondrial 1 21.469 TSP1_MOUSE Thrombospondin-1 1 17.3691 NUD15_MOUSE Probable 8-oxo-dGTP diphosphatase NUDT15 1 28.9634 TM143_MOUSE Transmembrane protein 143 1 56.3894 MIP18_MOUSE Mitotic spindle-associated MMXD complex subunit MIP18 1 38.4376 UBP24_MOUSE Ubiquitin carboxyl-terminal hydrolase 24 1 151.26 GNAQ_MOUSE Guanine nucleotide-binding protein G(q) subunit alpha 1 59.0977 MRE11_MOUSE Double-strand break repair protein MRE11A 1 41.4043 CA050_MOUSE Uncharacterized protein C1orf50 homolog 1 39.1983 CK074_MOUSE Uncharacterized protein C11orf74 homolog 1 42.0098 SSA27_MOUSE Sjoegren syndrome/scleroderma autoantigen 1 homolog 1 39.8197 SOSSC_MOUSE SOSS complex subunit C 1 76.7808 ERMP1_MOUSE Endoplasmic reticulum metallopeptidase 1 1 23.6943 PPBT_MOUSE Alkaline phosphatase, tissue-nonspecific isozyme 1 11.9535 WDR33_MOUSE pre-mRNA 3' end processing protein WDR33 1 77.4144 Q3U1C4_MOUSE MCG1271 1 20.7131 ARPC4_MOUSE Actin-related protein 2/3 complex subunit 4 1 53.4193 KI20B_MOUSE Kinesin-like protein KIF20B 1 32.596 F7BJB9_MOUSE Protein Morc3 1 44.9157 B0V2W3_MOUSE Protein Zfp952 (Fragment) 1 19.4056 ARFRP_MOUSE ADP-ribosylation factor-related protein 1 1 36.1231 F7DBB3_MOUSE Protein Ahnak2 (Fragment) 1 16.8002 HINT2_MOUSE Histidine triad nucleotide-binding protein 2, mitochondrial 1 33.6223 ADPPT_MOUSE L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 77.9181
EP
Osbpl1a Pigt Fam122a Riok1 Axin1 Klc2 Nr2c2ap Smyd5 Pknox1 Pja1 Nrf1 Prepl Fam86a Polr2j Cog6 Rnf25 Phactr4 Loh12cr1 D3Ertd751e Gpr1 Sh3bp4 Ubp1 Nanp Parvb Eno2 Smarcad1 Clp1 Slc25a46 Psmc3ip Tpk1 Dtnbp1 Atxn1l Rpl22l1 Foxo1 Ttc33 Bloc1s5 Klf8 Mapk8 Sco1 Thbs1 Nudt15 Tmem143 Fam96b Usp24 Gnaq Mre11a
AC C
sp|Q91XL9|OSBL1_MOUSE sp|Q8BXQ2|PIGT_MOUSE sp|Q9DB52|F122A_MOUSE sp|Q922Q2|RIOK1_MOUSE sp|O35625|AXIN1_MOUSE sp|O88448|KLC2_MOUSE sp|Q3TV70|NR2CA_MOUSE sp|Q3TYX3|SMYD5_MOUSE sp|O70477|PKNX1_MOUSE sp|O55176|PJA1_MOUSE sp|Q9WU00|NRF1_MOUSE sp|Q8C167|PPCEL_MOUSE sp|Q3UZW7|FA86A_MOUSE sp|O08740|RPB11_MOUSE sp|Q8R3I3|COG6_MOUSE sp|Q9QZR0|RNF25_MOUSE sp|Q501J7|PHAR4_MOUSE sp|Q9D920|L12R1_MOUSE sp|Q8BGN2|CD033_MOUSE sp|Q8K087|GPR1_MOUSE sp|Q921I6|SH3B4_MOUSE sp|Q811S7|UBIP1_MOUSE sp|Q9CPT3|NANP_MOUSE sp|Q9ES46|PARVB_MOUSE sp|P17183|ENOG_MOUSE sp|Q04692|SMRCD_MOUSE sp|Q99LI9|CLP1_MOUSE sp|Q9CQS4|S2546_MOUSE sp|O35047|HOP2_MOUSE sp|Q9R0M5|TPK1_MOUSE sp|Q91WZ8|DTBP1_MOUSE sp|P0C7T6|ATX1L_MOUSE sp|Q9D7S7|RL22L_MOUSE sp|Q9R1E0|FOXO1_MOUSE sp|Q9D6K7|TTC33_MOUSE sp|Q8R015|BL1S5_MOUSE sp|Q8BLM0|KLF8_MOUSE sp|Q91Y86|MK08_MOUSE sp|Q5SUC9|SCO1_MOUSE sp|P35441|TSP1_MOUSE sp|Q8BG93|NUD15_MOUSE sp|Q8VD26|TM143_MOUSE sp|Q9D187|MIP18_MOUSE sp|B1AY13|UBP24_MOUSE sp|P21279|GNAQ_MOUSE sp|Q61216|MRE11_MOUSE sp|Q5EBG8|CA050_MOUSE sp|Q9CQI4|CK074_MOUSE sp|P56873|SSA27_MOUSE sp|Q3TXT3|SOSSC_MOUSE sp|Q3UVK0|ERMP1_MOUSE sp|P09242|PPBT_MOUSE sp|Q8K4P0|WDR33_MOUSE tr|Q3U1C4|Q3U1C4_MOUSE sp|P59999|ARPC4_MOUSE sp|Q80WE4|KI20B_MOUSE tr|F7BJB9|F7BJB9_MOUSE tr|B0V2W3|B0V2W3_MOUSE sp|Q8BXL7|ARFRP_MOUSE tr|F7DBB3|F7DBB3_MOUSE sp|Q9D0S9|HINT2_MOUSE sp|Q9CQF6|ADPPT_MOUSE
26.5958 40.8352 35.6473 18.1835 21.1176 70.4377 44.5089 59.2406 86.4567 34.2399 26.6084 30.3451 31.687 48.7103 111.164 39.3892 28.6248 32.8799 80.6205 42.6973 51.8665 66.7897 18.5673 54.3832 27.1722 86.089 119.512 59.1085 38.5705 33.89 79.0018 22.0877 98.0727 48.6424 21.3468 117.21 27.3742 66.213 15.7421 62.2013 26.7003 51.0539 30.7115 192.727 32.9314 32.0096 29.2767 28.892 30.9268 64.9621 23.5967 9.32828 68.0593 17.8011 49.1826 40.5743 46.2794 20.0802 30.585 15.8826 30.0596 62.2743
23.8626 46.8293 32.3086 20.9284 14.3586 110.119 41.369 40.3232 76.3929 8.29677 20.7753 32.3871 37.9185 44.3141 160.881 30.3555 34.1263 34.9248 56.3935 25.4163 54.6596 49.7402 28.2431 86.3699 71.795 69.3473 111.834 34.4275 25.5113 24.4871 55.7464 15.0686 78.7329 36.5938 12.8395 79.5846 37.0805 74.84 10.9157 61.2229 21.6926 29.3832 65.4068 164.6 66.5142 42.3312 21.7702 29.5018 9.02406 57.7589 28.2628 115.932 71.5911 12.3281 57.5419 0.54281 48.4563 21.2912 45.653 7.51846 8.93695 56.7668
41.2389 46.7529 63.2453 23.319 34.9183 134.648 69.1365 52.5795 132.921 16.612 21.4 38.9585 50.2452 104.368 114.828 58.1484 16.0476 65.8107 114.29 49.7546 47.6404 41.083 48.8224 84.6714 37.6809 72.8148 163.378 49.2452 48.6614 41.8832 105.863 53.5901 118.478 75.6775 24.6023 154.093 33.0017 64.5883 15.7318 38.0897 39.8106 40.546 97.9686 175.752 38.3524 61.0336 61.6304 62.8893 11.8505 135.745 26.3328 148.555 102.551 42.269 48.7996 74.1876 39.4262 28.3798 43.2368 14.2543 45.6543 66.4989
0.90 0.90 0.90 0.90 0.90 0.90 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.89 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.88 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.87 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86 0.86
1.04 1.22 1.12 1.01 0.91 1.54 1.08 0.96 1.00 0.38 0.70 0.93 1.13 1.37 0.94 0.88 0.72 1.13 0.95 0.70 0.84 0.61 2.03 1.18 1.65 0.93 0.93 0.67 0.80 0.85 0.84 1.22 0.85 0.93 0.66 0.80 0.92 1.03 0.70 0.97 1.09 0.69 2.30 1.15 1.02 1.36 1.04 1.16 0.27 1.17 1.00 11.09 1.22 1.24 0.92 0.95 0.98 1.30 1.12 0.54 0.78 0.85
ACCEPTED MANUSCRIPT
24.1739 66.3887 45.2548 29.1952 48.0297 44.2015 39.4355 37.0645 34.7513 27.9428 59.9889 40.4069 74.8821 38.7746 25.4898 44.6463 58.7551 44.0046 116.374 20.773 45.9975 55.3638 39.9464 54.4471 82.9932 60.3619 53.1544 33.5923 103.542 50.1291 50.7717 41.479 88.8025 59.8976 90.5729 79.0008 91.0282 60.2452 34.0666 37.9988 93.3637 30.9994 87.5462 96.1073 42.8512 31.1304 51.7453 88.9689 70.1443 40.4944 66.3206 41.9918 42.976 31.1957 54.1784 37.0793 30.8321 85.0363 177.866 83.3912 58.7298 76.2407
28.601 57.091 45.9637 31.6886 45.0813 42.451 36.0651 28.9261 28.7573 25.0085 67.2626 35.2168 73.0927 34.5444 28.1152 47.1312 58.0709 45.3412 100.883 15.2402 43.9762 35.8363 35.1694 59.8653 59.6719 57.3866 47.6836 20.3318 63.9904 49.3207 42.4621 35.3092 73.1096 43.0345 86.1125 65.6395 73.8835 40.8132 24.1861 32.7151 74.4848 26.4829 62.7111 66.3432 34.9179 23.4413 42.1449 66.0962 50.9967 34.155 47.4362 33.2868 40.7189 19.2675 48.3311 31.5239 28.8387 109.997 135.254 71.5691 13.8981 63.0691
RI PT
35.2322 57.496 62.9438 36.031 63.0197 50.8495 43.5885 26.9003 28.6738 26.7299 88.1064 36.5922 86.4118 41.1713 29.8486 61.3495 66.0628 53.774 148.63 20.056 48.848 44.6088 38.1162 77.2923 72.112 70.6513 55.4033 19.2188 92.0842 63.5179 54.2862 41.4277 83.7225 50.1542 94.0857 91.7353 84.0732 63.2459 25.9886 33.6819 97.9187 24.8417 106.223 111.443 36.2112 24.1879 62.7901 86.0707 71.5066 42.9686 55.811 38.0042 42.7991 35.5332 76.3885 41.8972 37.2011 145.943 165.031 73.9367 32.9958 76.6037
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
Amotl1 Kdm3b Slc26a2 Pdcd2 Araf L3hypdh Pddc1 Spryd7 Polr2k Itpkc Metap1 Rbpj Hnrnpk Slc7a5 Desi2 Isca2 Lyrm9 Lrrc15 Wdr45 Tmem97 Prr14 Tns3 Pepd Coro7 Arl2bp Mgme1 Git2 Pbld2 Rlf Dhx38 Gmpr2 Khk Ptgfrn Cntln Ccdc110 Evl Ptma Crocc
TE D
Tead4 Ppig Gipc1 R3hdm2 Irak1 Radil Pnkd Fam185a Slc2a8 Poldip2 Phyh Bpgm Leprel4 Enpp3 Iws1 Oaf Arhgap18
NGRN_MOUSE Neugrin TF7L1_MOUSE Transcription factor 7-like 1 ANS1A_MOUSE Ankyrin repeat and SAM domain-containing protein 1A MICU2_MOUSE Calcium uptake protein 2, mitochondrial LTOR2_MOUSE Ragulator complex protein LAMTOR2 CU059_MOUSE UPF0769 protein C21orf59 homolog TEAD4_MOUSE Transcriptional enhancer factor TEF-3 PPIG_MOUSE Peptidyl-prolyl cis-trans isomerase G GIPC1_MOUSE PDZ domain-containing protein GIPC1 R3HD2_MOUSE R3H domain-containing protein 2 IRAK1_MOUSE Interleukin-1 receptor-associated kinase 1 RADIL_MOUSE Ras-associating and dilute domain-containing protein PNKD_MOUSE Probable hydrolase PNKD F185A_MOUSE Protein FAM185A GTR8_MOUSE Solute carrier family 2, facilitated glucose transporter member 8 PDIP2_MOUSE Polymerase delta-interacting protein 2 PAHX_MOUSE Phytanoyl-CoA dioxygenase, peroxisomal PMGE_MOUSE Bisphosphoglycerate mutase SC65_MOUSE Synaptonemal complex protein SC65 ENPP3_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 IWS1_MOUSE Protein IWS1 homolog OAF_MOUSE Out at first protein homolog RHG18_MOUSE Rho GTPase-activating protein 18 CX056_MOUSE UPF0428 protein CXorf56 homolog AMOL1_MOUSE Angiomotin-like protein 1 KDM3B_MOUSE Lysine-specific demethylase 3B S26A2_MOUSE Sulfate transporter PDCD2_MOUSE Programmed cell death protein 2 ARAF_MOUSE Serine/threonine-protein kinase A-Raf T3HPD_MOUSE Trans-L-3-hydroxyproline dehydratase PDDC1_MOUSE Parkinson disease 7 domain-containing protein 1 SPRY7_MOUSE SPRY domain-containing protein 7 RPAB4_MOUSE DNA-directed RNA polymerases I, II, and III subunit RPABC4 IP3KC_MOUSE Inositol-trisphosphate 3-kinase C MAP11_MOUSE Methionine aminopeptidase 1 SUH_MOUSE Recombining binding protein suppressor of hairless HNRPK_MOUSE Isoform 3 of Heterogeneous nuclear ribonucleoprotein K LAT1_MOUSE Large neutral amino acids transporter small subunit 1 DESI2_MOUSE Desumoylating isopeptidase 2 ISCA2_MOUSE Iron-sulfur cluster assembly 2 homolog, mitochondrial LYRM9_MOUSE LYR motif-containing protein 9 LRC15_MOUSE Leucine-rich repeat-containing protein 15 WIPI4_MOUSE WD repeat domain phosphoinositide-interacting protein 4 TMM97_MOUSE Transmembrane protein 97 PRR14_MOUSE Proline-rich protein 14 TENS3_MOUSE Tensin-3 PEPD_MOUSE Xaa-Pro dipeptidase CORO7_MOUSE Coronin-7 AR2BP_MOUSE ADP-ribosylation factor-like protein 2-binding protein MGME1_MOUSE Mitochondrial genome maintenance exonuclease 1 GIT2_MOUSE ARF GTPase-activating protein GIT2 PBLD2_MOUSE Phenazine biosynthesis-like domain-containing protein 2 A2A7F4_MOUSE Insulin-like 3 Q80X98_MOUSE DEAH (Asp-Glu-Ala-His) box polypeptide 38 GMPR2_MOUSE GMP reductase 2 KHK_MOUSE Ketohexokinase FPRP_MOUSE Prostaglandin F2 receptor negative regulator CNTLN_MOUSE Centlein CC110_MOUSE Coiled-coil domain-containing protein 110 EVL_MOUSE Ena/VASP-like protein PTMA_MOUSE Prothymosin alpha CROCC_MOUSE Rootletin
EP
Ngrn Tcf7l1 Anks1a Micu2 Lamtor2
AC C
sp|Q99KS2|NGRN_MOUSE sp|Q9Z1J1|TF7L1_MOUSE sp|P59672|ANS1A_MOUSE sp|Q8CD10|MICU2_MOUSE sp|Q9JHS3|LTOR2_MOUSE sp|Q8BL95|CU059_MOUSE sp|Q62296|TEAD4_MOUSE sp|A2AR02|PPIG_MOUSE sp|Q9Z0G0|GIPC1_MOUSE sp|Q80TM6|R3HD2_MOUSE sp|Q62406|IRAK1_MOUSE sp|Q69Z89|RADIL_MOUSE sp|Q69ZP3|PNKD_MOUSE sp|Q7TPD2|F185A_MOUSE sp|Q9JIF3|GTR8_MOUSE sp|Q91VA6|PDIP2_MOUSE sp|O35386|PAHX_MOUSE sp|P15327|PMGE_MOUSE sp|Q8K2B0|SC65_MOUSE sp|Q6DYE8|ENPP3_MOUSE sp|Q8C1D8|IWS1_MOUSE sp|Q8QZR4|OAF_MOUSE sp|Q8K0Q5|RHG18_MOUSE sp|Q8VDP2|CX056_MOUSE sp|Q9D4H4|AMOL1_MOUSE sp|Q6ZPY7|KDM3B_MOUSE sp|Q62273|S26A2_MOUSE sp|P46718|PDCD2_MOUSE sp|P04627|ARAF_MOUSE sp|Q9CXA2|T3HPD_MOUSE sp|Q8BFQ8|PDDC1_MOUSE sp|Q3TFQ1|SPRY7_MOUSE sp|Q63871|RPAB4_MOUSE sp|Q7TS72|IP3KC_MOUSE sp|Q8BP48|MAP11_MOUSE sp|P31266|SUH_MOUSE sp|P61979-3|HNRPK_MOUSE sp|Q9Z127|LAT1_MOUSE sp|Q9D291|DESI2_MOUSE sp|Q9DCB8|ISCA2_MOUSE sp|Q3UN90|LYRM9_MOUSE sp|Q80X72|LRC15_MOUSE sp|Q91VM3|WIPI4_MOUSE sp|Q8VD00|TMM97_MOUSE sp|Q7TPN9|PRR14_MOUSE sp|Q5SSZ5|TENS3_MOUSE sp|Q11136|PEPD_MOUSE sp|Q9D2V7|CORO7_MOUSE sp|Q9D385|AR2BP_MOUSE sp|Q9CXC3|MGME1_MOUSE sp|Q9JLQ2|GIT2_MOUSE sp|Q9CXN7|PBLD2_MOUSE tr|A2A7F4|A2A7F4_MOUSE tr|Q80X98|Q80X98_MOUSE sp|Q99L27|GMPR2_MOUSE sp|P97328|KHK_MOUSE sp|Q9WV91|FPRP_MOUSE sp|A2AM05|CNTLN_MOUSE sp|Q3V125|CC110_MOUSE sp|P70429|EVL_MOUSE sp|P26350|PTMA_MOUSE sp|Q8CJ40|CROCC_MOUSE
22.198 47.961 45.6652 23.4969 48.8195 37.8774 34.0801 25.045 24.7447 21.0357 57.413 29.5729 62.4665 32.5436 18.2861 41.5623 46.3319 36.3367 120.012 18.7392 34.9029 47.2026 29.567 49.2898 68.8022 51.1266 42.1167 23.3188 97.476 44.4128 44.1413 32.9454 68.7287 47.3948 65.3427 72.724 67.5899 58.4187 23.7722 24.4052 77.9154 17.958 91.2875 98.4249 27.4886 20.1763 48.0116 70.7852 59.4777 30.7782 47.4979 28.5171 25.5352 32.2721 52.413 29.3362 23.5339 67.544 124.457 47.5096 54.6757 50.4878
8.78512 40.3685 71.6379 36.3849 48.631 26.649 36.8915 34.3081 19.9061 12.3758 24.1358 24.582 25.1297 38.202 22.3155 22.6499 67.1228 59.894 64.5052 25.8798 23.8859 35.4161 18.619 19.1147 59.4911 49.3057 78.8716 14.4118 73.297 58.6409 52.0889 46.1894 77.6762 47.2857 47.4577 112.149 51.9116 71.783 22.4527 22.7135 44.7368 15.3183 79.5763 131.035 18.3982 27.0098 23.9681 74.96 42.8594 19.1999 71.3152 24.6548 2.29653 19.2708 38.0818 25.585 6.85977 64.0468 151.712 79.7548 42.8917 43.6676
31.8623 69.2689 94.3957 30.9643 55.7144 53.1197 45.7188 73.1394 26.3683 52.3794 52.8742 93.3608 29.4061 79.4988 21.1381 49.5441 115.003 62.8099 54.8625 41.8267 65.7317 67.6213 40.7754 22.4484 107.147 54.9974 39.2892 50.2075 98.6743 71.4903 90.2822 37.0628 125.855 73.6365 83.7302 82.3582 79.0518 98.684 48.2955 49.3822 137.714 30.3403 90.5484 105.152 35.3554 39.7489 11.0727 137.435 70.2633 36.6144 125.759 39.6725 0 25.0211 39.6927 30.6239 6.45414 186.078 201.988 151.965 165.541 47.1333
0.86 0.85 0.85 0.85 0.85 0.85 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.84 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.82 0.82 0.82 0.82 0.82 0.82 0.81 0.81 0.80 0.80 0.80 0.80 0.80 0.79 0.79 0.79 0.79 0.79 0.78 0.78 0.78 0.78 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.76 0.76 0.75 0.74
0.68 0.88 1.53 1.03 0.94 0.84 1.00 1.68 0.73 1.18 0.52 1.53 0.34 1.47 0.79 0.68 1.46 1.25 0.45 1.66 0.94 1.03 0.76 0.32 1.07 0.80 1.09 1.22 0.88 1.15 1.36 1.00 1.18 1.10 0.71 1.14 0.75 1.38 1.18 1.01 0.95 0.82 0.88 1.14 0.68 1.21 0.31 1.21 0.80 0.67 1.61 0.80 0.03 0.66 0.60 0.71 0.20 1.08 1.03 1.47 2.27 0.59
ACCEPTED MANUSCRIPT
34.1451 38.4605 94.8703 20.0581 28.1914 83.4278 49.2976 69.0127 47.7595 76.9776 58.7744 31.169 59.7715 49.4745 47.6121 35.749 80.7797 97.8933 31.7437 31.7479 58.003 23.5752 106.422 49.7238 58.5754 125.974 31.3573 82.9415 55.9483 56.4638 40.2402 50.8556 76.3887 93.9276 129.252 60.791 84.3456 380.501 44.8067 35.0464 30.36 94.8007 8.68772 159.838 38.7846 102.9 108.542 61.7414 118.026
27.0077 29.0346 75.7088 11.1139 23.0755 52.6985 36.9055 65.5389 24.0393 53.2193 44.4731 16.0353 45.4457 38.172 34.9516 26.6408 55.681 41.6935 24.2951 16.4572 30.7712 20.1793 34.5647 36.2238 35.1146 99.9815 16.1983 48.621 26.325 21.1899 34.9131 38.0893 46.4727 72.1874 128.261 50.9254 39.9917 312.747 30.46 12.9654 16.3036 38.4799 4.37358 58.9188 17.4026 21.6116 34.4264 31.5973 10.408
RI PT
41.6809 53.6689 88.284 12.3219 29.1247 73.9614 49.8523 82.6769 35.0924 64.3495 50.1508 17.7834 63.1644 54.9119 41.7406 31.5425 82.489 112.465 36.1502 20.086 56.8222 28.113 35.8465 52.4644 64.9009 120.802 12.4014 61.5631 36.1229 22.2641 57.6037 57.446 122.09 120.372 216.392 69.1814 57.2133 510.307 79.2979 30.8391 23.8593 34.2104 5.51561 10.681 20.9768 204.731 7.08481 94.0357 28.7547
SC
1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
M AN U
TE D
BCCIP_MOUSE BRCA2 and CDKN1A-interacting protein DGUOK_MOUSE Deoxyguanosine kinase, mitochondrial SNX7_MOUSE Sorting nexin-7 SRBP2_MOUSE Sterol regulatory element-binding protein 2 PTPRM_MOUSE Receptor-type tyrosine-protein phosphatase mu PPOX_MOUSE Protoporphyrinogen oxidase PHOCN_MOUSE MOB-like protein phocein MET10_MOUSE Methyltransferase-like protein 10 SET_MOUSE Isoform 2 of Protein SET B7ZNC5_MOUSE Protein Srsf11 NC2B_MOUSE Protein Dr1 Q9D1M1_MOUSE DNA-directed RNA polymerases I and III subunit RPAC2 PALD_MOUSE Paladin HYI_MOUSE Putative hydroxypyruvate isomerase BAG2_MOUSE BAG family molecular chaperone regulator 2 RN115_MOUSE E3 ubiquitin-protein ligase RNF115 NAPSA_MOUSE Napsin-A ATP6_MOUSE ATP synthase subunit a NAAA_MOUSE N-acylethanolamine-hydrolyzing acid amidase P5CR1_MOUSE Pyrroline-5-carboxylate reductase 1, mitochondrial IFT25_MOUSE Intraflagellar transport protein 25 homolog CBPD_MOUSE Carboxypeptidase D F110C_MOUSE Protein FAM110C PHYD1_MOUSE Phytanoyl-CoA dioxygenase domain-containing protein 1 EZH1_MOUSE Histone-lysine N-methyltransferase EZH1 GPR64_MOUSE G-protein coupled receptor 64 FAKD2_MOUSE FAST kinase domain-containing protein 2 RIPL2_MOUSE RILP-like protein 2 D3Z2Y6_MOUSE Protein S100a16 (Fragment) PRG4_MOUSE Proteoglycan 4 SNTA1_MOUSE Alpha-1-syntrophin TGM2_MOUSE Protein-glutamine gamma-glutamyltransferase 2 TM109_MOUSE Transmembrane protein 109 NEUR1_MOUSE Sialidase-1 E9Q2T3_MOUSE Protein Tnxb DHYS_MOUSE Deoxyhypusine synthase U119A_MOUSE Protein unc-119 homolog A AATF_MOUSE Protein AATF PEF1_MOUSE Peflin SETD7_MOUSE Histone-lysine N-methyltransferase SETD7 DNS2A_MOUSE Deoxyribonuclease-2-alpha B7ZC50_MOUSE Heat shock protein HSP 90-alpha (Fragment) AGTRA_MOUSE Type-1A angiotensin II receptor MT2_MOUSE Metallothionein-2 RL40_MOUSE Ubiquitin-60S ribosomal protein L40 FITM2_MOUSE Fat storage-inducing transmembrane protein 2 TYB4_MOUSE Thymosin beta-4 E9PV38_MOUSE Protein Ces2g D3YYI5_MOUSE Glyceraldehyde-3-phosphate dehydrogenase
EP
Bccip Dguok Snx7 Srebf2 Ptprm Ppox Mob4 Mettl10 Set Srsf11 Dr1 Polr1d Pald1 Hyi Bag2 Rnf115 Napsa Mtatp6 Naaa Pycr1 Hspb11 Cpd Fam110c Phyhd1 Ezh1 Gpr64 Fastkd2 Rilpl2 S100a16 Prg4 Snta1 Tgm2 Tmem109 Neu1 Tnxb Dhps Unc119 Aatf Pef1 Setd7 Dnase2 Hsp90aa1 Agtr1a Mt2 Uba52 Fitm2 Tmsb4x Ces2g Gm7293
AC C
sp|Q9CWI3|BCCIP_MOUSE sp|Q9QX60|DGUOK_MOUSE sp|Q9CY18|SNX7_MOUSE sp|Q3U1N2|SRBP2_MOUSE sp|P28828|PTPRM_MOUSE sp|P51175|PPOX_MOUSE sp|Q6PEB6|PHOCN_MOUSE sp|Q9D853|MET10_MOUSE sp|Q9EQU5-2|SET_MOUSE tr|B7ZNC5|B7ZNC5_MOUSE sp|Q91WV0|NC2B_MOUSE tr|Q9D1M1|Q9D1M1_MOUSE sp|P70261|PALD_MOUSE sp|Q8R1F5|HYI_MOUSE sp|Q91YN9|BAG2_MOUSE sp|Q9D0C1|RN115_MOUSE sp|O09043|NAPSA_MOUSE sp|P00848|ATP6_MOUSE sp|Q9D7V9|NAAA_MOUSE sp|Q922W5|P5CR1_MOUSE sp|Q9D6H2|IFT25_MOUSE sp|O89001|CBPD_MOUSE sp|Q8VE94|F110C_MOUSE sp|Q9DB26|PHYD1_MOUSE sp|P70351|EZH1_MOUSE sp|Q8CJ12|GPR64_MOUSE sp|Q922E6|FAKD2_MOUSE sp|Q99LE1|RIPL2_MOUSE tr|D3Z2Y6|D3Z2Y6_MOUSE sp|Q9JM99|PRG4_MOUSE sp|Q61234|SNTA1_MOUSE sp|P21981|TGM2_MOUSE sp|Q3UBX0|TM109_MOUSE sp|O35657|NEUR1_MOUSE tr|E9Q2T3|E9Q2T3_MOUSE sp|Q3TXU5|DHYS_MOUSE sp|Q9Z2R6|U119A_MOUSE sp|Q9JKX4|AATF_MOUSE sp|Q8BFY6|PEF1_MOUSE sp|Q8VHL1|SETD7_MOUSE sp|P56542|DNS2A_MOUSE tr|B7ZC50|B7ZC50_MOUSE sp|P29754|AGTRA_MOUSE sp|P02798|MT2_MOUSE sp|P62984|RL40_MOUSE sp|P59266|FITM2_MOUSE sp|P20065|TYB4_MOUSE tr|E9PV38|E9PV38_MOUSE tr|D3YYI5|D3YYI5_MOUSE
29.2976 39.2732 59.8895 12.8149 19.1547 62.8772 35.827 45.5732 36.2668 49.4776 34.5801 19.4509 42.6885 36.3142 28.3609 20.8135 59.3049 103.356 22.3972 19.1745 47.9961 14.9123 61.1874 32.5206 47.6908 65.0275 12.9792 47.5875 34.0603 30.3079 28.897 32.0921 79.8581 63.1769 83.082 27.6924 45.2886 221.874 41.541 24.5819 14.3606 34.0668 2.93777 28.5291 11.993 127.366 13.1814 21.1937 12.6712
50.9993 52.1758 97.0824 22.2439 13.7431 35.4436 41.754 53.2633 54.0554 63.3835 28.9204 7.20857 76.9547 26.7055 34.2337 21.8831 17.1414 30.6481 21.8917 56.4924 36.0322 35.423 13.0498 8.97347 86.5259 51.5452 21.8089 33.4056 13.0151 134.151 27.8472 58.3705 23.5069 39.3905 43.7698 61.5921 47.2436 307.696 44.7814 28.9586 12.8532 103.065 426.705 88.6618 79.4337 104.725 10.4515 54.7851 17.0378
63.4091 68.8948 103.421 45.9607 7.6949 75.9842 47.8046 55.426 87.8281 128.115 47.4745 28.5829 46.246 48.2415 64.5138 83.8848 14.5893 75.0667 18.2836 75.476 37.5562 15.1044 129.409 22.3534 111.805 160.168 24.789 109.616 63.1939 194.208 39.2778 68.7578 32.7167 41.1302 45.844 77.0314 115.866 145.907 60.91 55.6387 20.919 135.561 422.979 64.7438 139.258 128.321 30.8154 25.6569 20.5979
0.74 0.74 0.74 0.74 0.74 0.73 0.73 0.73 0.73 0.73 0.73 0.72 0.72 0.71 0.71 0.71 0.70 0.69 0.69 0.69 0.69 0.68 0.67 0.67 0.67 0.67 0.67 0.67 0.66 0.65 0.65 0.65 0.64 0.63 0.61 0.60 0.60 0.60 0.58 0.57 0.57 0.56 0.51 0.51 0.49 0.48 0.41 0.34 0.16
1.51 1.31 1.09 2.11 0.37 0.71 0.90 0.72 1.71 1.36 0.70 0.73 1.00 0.72 1.11 1.57 0.19 0.50 0.59 2.55 0.64 0.98 1.00 0.31 1.61 0.86 1.06 0.99 0.83 4.17 0.69 1.17 0.28 0.38 0.26 1.07 1.15 0.51 0.85 1.28 0.62 1.85 59.82 0.90 3.66 0.76 0.36 0.52 0.26
ACCEPTED MANUSCRIPT
Table S2. Selected proteins from a TMT proteomic analysis of epididymal adipose tissue from WT and adiporedoxin null mice
AC C
EP
TE D
M AN U
Adipokines A2m Alpha-2-macroglobulin Adipoq Adiponectin Apoa1 Apolipoprotein A-I Dpp4 Dipeptidyl peptidase 4 Igfbp4 Insulin-like growth factor-binding protein 4 Lgmn Legumain Orm1 Alpha-1-acid glycoprotein 1 Retn Resistin Collagens Col1a1 Collagen alpha-1(I) chain Col1a2 Collagen alpha-2(I) chain Col3a1 Collagen alpha-1(III) chain Col4a1 Collagen alpha-1(IV) chain Col4a2 Collagen alpha-2(IV) chain Col5a1 Collagen alpha-1(V) chain Col5a2 Collagen alpha-2(V) chain Col6a1 Collagen alpha-1(VI) chain Col6a2 Collagen alpha-2(VI) chain Col6a3 Collagen alpha-6(VI) chain Col6a5 Collagen alpha-5(VI) chain Col6a6 Collagen alpha-6(VI) chain Col12a1 Isoform 2 of Collagen alpha-1(XII) chain Col14a1 Collagen, type XIV, alpha 1 Col15a1 Collagen alpha-1(XV) chain Col18a1 Collagen alpha-18 chain ER Thioredoxin fold proteins FAM213a Adiporedoxin Ero1l ERO1-like protein alpha Erp29 Endoplasmic reticulum resident protein 29 Erp44 Endoplasmic reticulum resident protein 44 P4hb/PDIA1 Protein disulfide-isomerase Pdia3/Erp57 Protein disulfide-isomerase A3 Pdia4/Erp72 Protein disulfide-isomerase A4 Pdia5 Protein disulfide-isomerase A5 Pdia6 Protein disulfide-isomerase A6 Prdx4 Peroxiredoxin-4 Tmx1 Thioredoxin-related transmembrane protein 1 Tmx2 Thioredoxin-related transmembrane protein 2 Tmx3 Protein disulfide-isomerase TMX3
Peptides #
KO/WT
128 21 114 12 2 6 12 19
1.21 1.22 1.22 1.21 1.27 1.17 1.05 1.13
57 32 15 6 15 10 16 135 85 315 146 22 18 74 58 18
0.52 0.59 0.76 0.67 0.60 0.75 0.74 0.64 0.63 0.67 0.61 0.71 0.65 0.66 0.91 0.77
19 16 28 17 113 109 81 6 39 13 7 6 7
0.06 1.05 1.06 0.98 1.00 0.98 1.05 1.06 1.03 1.07 0.92 0.82 1.00
RI PT
Description
SC
Gene Symbol
ACCEPTED MANUSCRIPT
Adrx
A.
Adiponectin
B.
3 2 1
5
SV F B ra i C n ol on H ea Sm rt In t Li ve r Lu M ng us cl e
SC A T FC
M AN U
SV F B ra i C n ol on H ea Sm rt In t Li ve r Lu M ng us cl e
FC
0
A T
0
10
RI PT
Relative expression
Relative expression
4
C.
AC C
EP
TE D
D.
Figure S1 related to Figure 6 Adrx expression in human adipocytes parallels that in mouse fat cells and affects adiponectin secretion. The mRNA distribution of Adrx A. and adiponectin B. in abdominal subcutaneous adipose tissue (AT), and isolated fat cells (FC) and stromal-vascular fractions (SVF) obtained after collagenase digestion is shown in comparison to the other tissues lindicated (n=3). C. Adrx mRNA and protein shows a marked increase in expression during the differentiation of human preadipocytes. The data are expressed as % of one of the 4 cultures that was set to an arbitrary value of 1. D. (I.-IV.) shows that knockdown of Adrx mRNA and protein did not decrease adiponectin mRNA, but markedly decreased the secretion of (HMW) and lower molecular weight forms (MMW and LMW) into the medium. The data in all panels are representative of 3 or more independent experiments. The data in panel D were reproduced in cells from 2 individuals.
ACCEPTED MANUSCRIPT
A
600 500
(%)
400 300
100 0 P58IPK
400
HERP
EDEM1
KO
EP
TE D
(%)
200
0
WARS
WT
300
100
EDEM1
M AN U
CHOP
SC
200
B
KO
RI PT
WT
AC C
F4/80
TNFa
CD11b
Figure S2 related to Figure 5 mRNA Expression of adipocyte ER stress and inflammation markers in the Adrx null and wild type mice. A. ER stress markers (HERP: homocysteine-induced ER protein; CHOP: CAAT/enhancer binding protein (C/EBP) homologous protein; EDEM1: ER degradation enhancer, mannosidase alphalike 1; WARS: tryptophanyl tRNA synthetase; P58IPK: p58 inhibitor of interferon-induced double-stranded RNA-activated protein kinase) and B. Inflammatory markers were measured by RT-qPCR from 8-week old adrx null and wild types mice adipose tissue.
ACCEPTED MANUSCRIPT
B
C Lean (%)
Fat (%)
70.0
50 45
45.0 40.0
60.0
40
35.0
50.0
30.0
40.0
%
%
30
25
20.0
30.0
15
15.0
SC
20
20.0
10.0
10
10.0
5 0 8
10
12
14 16 Week(s)
18
20
22
5.0
0.0
24
0.0
KO
D
E 2
Fasting Glucose
120
Fasting Insulin
TE D
1.5
WT
M AN U
6
ng/ml
100 80 60
40
1
0.5
20 KO
EP
WT
WT
KO
WT
F IPGTT 600 WT
500
KO
400 300
200 100
0
0
AC C
mg/dl
25.0
Glucose (mg/dl)
Body Weight (g)
35
140
RI PT
A
KO
0 0
30 60 90 Time (min)
120
Figure S3 related to Figure 5 Metabolic characteristics of 7 month old Adrx null mice. Body weight growth (A), Body composition lean (B) and fat (C) mass, fasting serum glucose (D) and insulin (E) and glucose tolerance (F) were measured from 7month old adrx null and wild type mice.
ACCEPTED MANUSCRIPT
LFD
A. Male
HFD
RI PT
Adrx aP2
SC
Tubulin
TE D d.
Adrx
aP2 Tubulin Actin
LF HF
AC C
EP
C.
M AN U
B. Female
Actin
Figure S4 related to Figure 5 Adiporedoxin expression is reduced in epididymal adipose tissue from obese, high fad fed (HFD) male mice. A. Male (6/condition) and female B (5/condition) were fed a "chow” (LFD) diet or a HFD for 14 weeks and the expression of the indicated proteins in white adipose tissue lysates was determined by immunoblotting following SDS-PAGE. B. The gels were scanned and quantitatively analyzed as in other figures (mean +S.E.M., p< 0.05, n = 6). C. Serum HMW adiponectin was measured in the mice from A and plotted as the ratio of HMW/total adiponectin normalized to adipocyte Adrx/tubulin.