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Administration of Erythropoietin in a swine model of prolonged cardiac arrest
Resuscitation 85S (2014) S4–S14
Contents lists available at ScienceDirect
Resuscitation journal homepage: www.elsevier.com/locate/resuscitation
Resuscitation 2014, ERC Symposium on Guidelines: Abstract Presentations
Oral Presentations Advanced Life Support AS001 Administration of Erythropoietin in a swine model of prolonged cardiac arrest Panagiotis Vasileiou 1 , Theodoros Xanthos 1,∗ , Dimitrios Barouxis 2 , Charalampos Pantazopoulos 2 , Apostolos Papalois 3 , Pavlos Lelovas 1 , Olympia Kotsilianou 2 , Evita Pliatsika 1 , Evangelia Kouskouni 1 , Nicoletta Iacovidou 1 1
of shocks in comparison with animals that received normal saline (p = 0.04). Furthermore, the neurologic alertness score was higher in the EPO group compared to placebo at 24 (p = 0.004) and 48 hours (p = 0.021). Conclusion: Administration of rh-EPO in a pig model of VFinduced CA just before reperfusion facilitates ROSC and improves survival rates as well as hemodynamic variables. http://dx.doi.org/10.1016/j.resuscitation.2014.03.021
Basic Life Support AS002 Using surveillance video for insight into Out-of-Hospital Cardiac Arrest (OHCA)
National and Kapodistrian University of Athens, Medical School, MSc “Cardiopulmonary Resuscitation”, Athens, Greece 2 Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece 3 Experimental-Research Centre ELPEN, Athens, Greece
1
Purpose of the study: Recombinant human erythropoietin (rhEPO) has been shown to exert tissue protective properties in various experimental models. However, its potential role in the cardiac arrest (CA) setting has not yet been sufficiently elucidated. The purpose of our study was to evaluate the effect of rh-EPO administration in swine model of ventricular fibrillation (VF) CA. The primary goal of our study was to investigate whether rh-EPO exerts any beneficial effect on Return of Spontaneous Circulation (ROSC) rates, while the secondary aim was to assess its impact in the shortterm basis of 24-h and 48-h survival. Materials and methods: VF was electrically induced in 20 piglets and remained untreated for 8 min before attempting resuscitation. Animals were randomized to receive rh-EPO (5000 IU kg−1 , EPO group, n = 10) immediately before the initiation of chest compressions, or to receive 0.9% NaCl solution instead (control group, n = 10). Endpoints of the experiment were defined as either asystole or ROSC. Results: Compared with controls, the EPO group had higher rates of ROSC (100% vs 60%, p = 0.011), and higher 48-h survival (100% vs 40%, p = 0.001). Diastolic aortic pressure (DAoP) and coronary perfusion pressure (CPP) during cardiopulmonary resuscitation (CPR) were significantly higher in the EPO group compared to the placebo group. EPO treated animals required fewer number
Background: Bystander and telephone assisted cardiopulmonary resuscitation (CPR) is important, however little is known about the first critical minutes. On 8th of July 2013, a 57 year old man collapsed with OHCA at a train station in Copenhagen. The incident was captured on closed circuit television (CCTV). We combined CCTV and audio recordings from the emergency medical dispatcher (EMD) in order to identify the learning possibilities. Methods: A qualitative approach based on systematic text condensation with NVivio 10 software. We focused on the interval from collapse until the arrival of an ambulance. Results: Themes (1) organization: Call-processing-time was 101 s (measured from bystander call to the emergency services until the caller was connected to EMD); (2) communication between EMD and caller versus observed by CTTV: The caller could not see the patient very well. EMD was not aware of this and did not realize that the patient had cardiac arrest before CPR was started by other bystanders. The caller himself was not performing CPR, but the CPR instruction was given to him. EMD informed about the
0300-9572/$ – see front matter
Gitte Linderoth 1,∗ , Peter Hallas 2 , Doris Østergaard 3 , Thea Palsgaard 1 , Pernille Pitre 1 , Ida Wibrandt 1 , Freddy Lippert 1 Prehospital Department – the Emergency Unit in the Capital Region, Copenhagen, Denmark 2 Department of Anaesthesiology, Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark 3 Danish Institute for Medical Simulation, Herlev Hospital, Copenhagen, Denmark
Contents lists available at ScienceDirect
Resuscitation journal homepage: www.elsevier.com/locate/resuscitation
Resuscitation 2014, ERC Symposium on Guidelines: Abstract Presentations
Oral Presentations Advanced Life Support AS001 Administration of Erythropoietin in a swine model of prolonged cardiac arrest Panagiotis Vasileiou 1 , Theodoros Xanthos 1,∗ , Dimitrios Barouxis 2 , Charalampos Pantazopoulos 2 , Apostolos Papalois 3 , Pavlos Lelovas 1 , Olympia Kotsilianou 2 , Evita Pliatsika 1 , Evangelia Kouskouni 1 , Nicoletta Iacovidou 1 1
of shocks in comparison with animals that received normal saline (p = 0.04). Furthermore, the neurologic alertness score was higher in the EPO group compared to placebo at 24 (p = 0.004) and 48 hours (p = 0.021). Conclusion: Administration of rh-EPO in a pig model of VFinduced CA just before reperfusion facilitates ROSC and improves survival rates as well as hemodynamic variables. http://dx.doi.org/10.1016/j.resuscitation.2014.03.021
Basic Life Support AS002 Using surveillance video for insight into Out-of-Hospital Cardiac Arrest (OHCA)
National and Kapodistrian University of Athens, Medical School, MSc “Cardiopulmonary Resuscitation”, Athens, Greece 2 Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece 3 Experimental-Research Centre ELPEN, Athens, Greece
1
Purpose of the study: Recombinant human erythropoietin (rhEPO) has been shown to exert tissue protective properties in various experimental models. However, its potential role in the cardiac arrest (CA) setting has not yet been sufficiently elucidated. The purpose of our study was to evaluate the effect of rh-EPO administration in swine model of ventricular fibrillation (VF) CA. The primary goal of our study was to investigate whether rh-EPO exerts any beneficial effect on Return of Spontaneous Circulation (ROSC) rates, while the secondary aim was to assess its impact in the shortterm basis of 24-h and 48-h survival. Materials and methods: VF was electrically induced in 20 piglets and remained untreated for 8 min before attempting resuscitation. Animals were randomized to receive rh-EPO (5000 IU kg−1 , EPO group, n = 10) immediately before the initiation of chest compressions, or to receive 0.9% NaCl solution instead (control group, n = 10). Endpoints of the experiment were defined as either asystole or ROSC. Results: Compared with controls, the EPO group had higher rates of ROSC (100% vs 60%, p = 0.011), and higher 48-h survival (100% vs 40%, p = 0.001). Diastolic aortic pressure (DAoP) and coronary perfusion pressure (CPP) during cardiopulmonary resuscitation (CPR) were significantly higher in the EPO group compared to the placebo group. EPO treated animals required fewer number
Background: Bystander and telephone assisted cardiopulmonary resuscitation (CPR) is important, however little is known about the first critical minutes. On 8th of July 2013, a 57 year old man collapsed with OHCA at a train station in Copenhagen. The incident was captured on closed circuit television (CCTV). We combined CCTV and audio recordings from the emergency medical dispatcher (EMD) in order to identify the learning possibilities. Methods: A qualitative approach based on systematic text condensation with NVivio 10 software. We focused on the interval from collapse until the arrival of an ambulance. Results: Themes (1) organization: Call-processing-time was 101 s (measured from bystander call to the emergency services until the caller was connected to EMD); (2) communication between EMD and caller versus observed by CTTV: The caller could not see the patient very well. EMD was not aware of this and did not realize that the patient had cardiac arrest before CPR was started by other bystanders. The caller himself was not performing CPR, but the CPR instruction was given to him. EMD informed about the
0300-9572/$ – see front matter
Gitte Linderoth 1,∗ , Peter Hallas 2 , Doris Østergaard 3 , Thea Palsgaard 1 , Pernille Pitre 1 , Ida Wibrandt 1 , Freddy Lippert 1 Prehospital Department – the Emergency Unit in the Capital Region, Copenhagen, Denmark 2 Department of Anaesthesiology, Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark 3 Danish Institute for Medical Simulation, Herlev Hospital, Copenhagen, Denmark