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ADVANCED PARAMETERS OF CARDIAC MECHANICS IN CHILDREN WITH CHRONIC KIDNEY DISEASE: THE 4C STUDY
A1098 JACC April 1, 2014 Volume 63, Issue 12
Non Invasive Imaging Advanced Parameters of Cardiac Mechanics in Children with Chronic Kidney Disease: The 4C Study Poster Contributions Hall C Saturday, March 29, 2014, 3:45 p.m.-4:30 p.m.
Session Title: Non Invasive Imaging: Advances in Echocardiography Abstract Category: 15. Non Invasive Imaging: Echo Presentation Number: 1138-58 Authors: Marcello Chinali, Alessio Franceschini, MariaChiara Matteucci, Doyon Anke, Claudia Esposito, Gabriele Rinelli, Giacomo Pongiglione, Franz Schaefer, Bambino Gesù Pediatric Hospital, Rome, Italy Background: Chronic kidney disease (CKD) in children is associated with high risk of develpment of cardiac failure. Information on the prevalence of abnormalities in cardiac mechanics in CKD children are lacking. Methods: The 4C-study comprises CKD pediatric patients from 14 European countries. Cardiac morphology and function is assessed in a subgroup of patients by echocardiography. Analysis includes study of 2-dimensional radial (Rε), longitudinal (Lε), and circumferential (Cε) strain (endocardial and epicardial), as well as analysis of systolic synchrony. Result: Data on 200 echocardiographic exams analyzed are reported. Mean age was 12.8±3.5yrs (69% boys). All patients showed ejection fraction>55%. As compared to reference values from a matched healthy population, 32% of the strain values in CKD were below normal. A strong association was found between the reduction in Rε and circumferential endocardial-to-epicardial gradient (CS_grad; fig.1;p<0.01), also controlling for clinical characteristics, systolic/diastolic blood pressure, eGFR, LV mass and wall thickness. Reduced cardiac strain was also significantly associated to the presence of increased opposite wall delay in cardiac contraction (p<0.005). Conclusion: Despite the young age and a normal ejection fraction, one in three children with CKD have reduced indices of systolic strain. Impaired cardiac function is related to reduced circumferential systolic transmural gradient and to evidence of cardiac systolic dyssynchrony.
Non Invasive Imaging Advanced Parameters of Cardiac Mechanics in Children with Chronic Kidney Disease: The 4C Study Poster Contributions Hall C Saturday, March 29, 2014, 3:45 p.m.-4:30 p.m.
Session Title: Non Invasive Imaging: Advances in Echocardiography Abstract Category: 15. Non Invasive Imaging: Echo Presentation Number: 1138-58 Authors: Marcello Chinali, Alessio Franceschini, MariaChiara Matteucci, Doyon Anke, Claudia Esposito, Gabriele Rinelli, Giacomo Pongiglione, Franz Schaefer, Bambino Gesù Pediatric Hospital, Rome, Italy Background: Chronic kidney disease (CKD) in children is associated with high risk of develpment of cardiac failure. Information on the prevalence of abnormalities in cardiac mechanics in CKD children are lacking. Methods: The 4C-study comprises CKD pediatric patients from 14 European countries. Cardiac morphology and function is assessed in a subgroup of patients by echocardiography. Analysis includes study of 2-dimensional radial (Rε), longitudinal (Lε), and circumferential (Cε) strain (endocardial and epicardial), as well as analysis of systolic synchrony. Result: Data on 200 echocardiographic exams analyzed are reported. Mean age was 12.8±3.5yrs (69% boys). All patients showed ejection fraction>55%. As compared to reference values from a matched healthy population, 32% of the strain values in CKD were below normal. A strong association was found between the reduction in Rε and circumferential endocardial-to-epicardial gradient (CS_grad; fig.1;p<0.01), also controlling for clinical characteristics, systolic/diastolic blood pressure, eGFR, LV mass and wall thickness. Reduced cardiac strain was also significantly associated to the presence of increased opposite wall delay in cardiac contraction (p<0.005). Conclusion: Despite the young age and a normal ejection fraction, one in three children with CKD have reduced indices of systolic strain. Impaired cardiac function is related to reduced circumferential systolic transmural gradient and to evidence of cardiac systolic dyssynchrony.