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Aflatoxins in sera from patients with lung cancer
393
Soluble interleukin-2 receptor and soluble CDS antigen levels in serum from patients with non-resectable lung cancer V&-Petersen J, Tvede N, Diamant M, Amt Kjerulff A, Rahbck Sorensen H, Andersen V. Sfeno Memorial Hospira/, 2 Nit/s Steensens Vej. DK-2820Genfofe. Cancer Immunol Immunother 1991;33:121-7. In a preliminary longitudinal study two women with histologically verilied adenocarcinoma of the lung, without simultaneous infectious or inflammatory conditions, were seen every 2 weeks until death. In one of the patients serum soluble interleukin-2 receptor (sIL-2R) levels rose progressively while the levels for the other patient increased during the second half of the observation period. Serum soluble CD8 antigen (sCD8 Ag) showed a pattern dissimilar to the one for sIL-2R. In a retrospective cross-sectional study circulating levels of sIL-2R and sCD8 Ag were measured before explorative thoracotomy in a total of 65 patients with histologically proven non-resectable carcinoma of the lung. The sIL-2R levels were significantly increased independently of histological subclassification while sCD8 Ag was increased only in patients with small-cell lung cancer. There was no correlation between pre-operative values and length of survival.
negativepointwasmade upfortosomeextentbyevaluating thenumber of positive markers. In monitoring the clinical course, independent changes were observed in markers in some cancer paoents. These results implied that measuring multiple tumor markers was of climcal value in monitoring the clinical course of cancer patients as well as in assisting the diagnosis of lung cancer.
Allatoxins in sera from patients with lung cancer Cusumano V. Microbiology Institute, Faculty of Medicine, Piazza XX Setfembre, I-98100 Messina. Oncology (Switzerland) 1991:48:194-5. Sera from patients with lung cancer and from healthy donors were screened for the presence of aflatoxins. Significant differencesin levels of aflatoxins between the two groups were found. Only 1 of the neoplastic patients with aflatoxins in the serum was a smoker. However the percentage of sera from lung cancer containmg aflatoxins 1s not significant enough to provide evidence for a casual relationship hetween aflatoxins exposure and development of lung cancer in humans.
Theprognmticsignificanceofpretreatmentserumlactatedehydrogenase in patients with small-cell lung cancer Sagman U, Feld R, Evans WK, Warr D, Shepherd FA, Payne D, et al. Ontario Cancer Institute. 500 Sherbourne Sr, Toronto. Onr. M4X IK9. J Clin Oncol 1991;9:954-61. Pretreatment serum lactate dehydrogenase (LDH) levels were assayed in 288 patients presenting with small-cell lung cancer (SCLC) between 1976 and 1985. Patients were routinely staged by physical examination,chestx-ray,bone,brain,andliverscans,andbonemarrow evaluation. Clinical response and survival were assessed following treatment with combination chemotherapy as part of four clinical trials. Patients with extensive disease (ED) presented with a higher incidence (108of 147.73%)ofabno~allyelevatedLDH(~ 193 IU/L.)thanthose (65 of 141.46%) with limiteddisease (P=2 x 104. Forty percent of patients had an initial normal LDH level and a higher response rate (89 of 108, 82%; complete response [CR], 47%) than those wth elevated values of LDH (1 I9 of 156, 76%: CR, 29%). ‘IIre CR rate varied inversely with the level of LDH in patients with LD (P= ,026) but not in those with ED (P = ,300). The median survival time and I-year and 2-year survival rates for patients with elevated LDH were 39 weeks and 33% and 6%. respectively, whereas for those with a normal LDH level these were 53 weeks and 54% and 16%. respectively. Patients with LD and elevated levels of LDH manifested a higher relative death rate (I .63: 1) when compared with patients with LD and LDH in the normal range (P = .0083). The survival of patients with ED did not differ between those with normal and elevated levels of LDH (P = ,273). A significant survival advantage persisted for patients with LDH in the normal range following adjustments for extent of disease, performance status (PS), and treatment protocol (P = ,044, log-rank analysis). In conclusion, serum LDH appears to be a significant independent pretreatment prognostic factor in patients with SCLC that correlates with stage of disease, response to treatment. and survival.
Computed tomography distinction of central thoracic masses Woodring JH, Johnson PI. Deparrmenr of Diagnostic Radiology, University of Kentucky Medical Center, 800 Rose Street, Lexington. KY 40536-0084. J Tborac Imaging 1991:6:32-9. In an analysis of 36 central lung, 54 mediastinal, and 10 central pleural masses, features were sought that would allow accurate localization of the mass by CT. The mass-lung interface was the most useful feature: with few exceptions a mass with a spiculated, nodular, or irregular edge was in (he lung, and a mass with a smooth edge was in the mediastinum. In the superior mediastinal, supraazygos, and supraaortic regions lung masses were lateral to the great vessels, and mediastinal masses were medial to the great vessels. Anterior mediastinal masses were typically positioned between the sternum and great vessels: some were more laterally positioned, however, and could only bc distinguished from lung masses by the mass-lung interface. In the infraazygas, infraaortic,andparaspinal areas, lungand mediastinal masses were best differentiated by the mass-lung interface. The angles formed between the mass and lung were occasionally helpful in localizing the mass. Central pleural masses were characterized by a lack of intimate mediastinal effect, obtuse angles between the mass and lung, a smooth mass-lung interface, and characteristic association with other similar areas of involvement in the pleural space. These criteria were used for thecorrectlocalizationof99of lOOmasses: therefore,theycansimplify and focus the work-up of most central thoracic masses. Clinical evaluation oftive tumor marker assay in patients with lung cancer Mizushima Y, Tsuji H, Izumi S, Hirata H, Kin Y, Kawasaki A, et al. lstDepanmentoflnterna1 Medicine. ToyamaMedicalandPharmaceurical (iniversity. Toyama 930-01, Anticancer Res 1991: 11:91-5. Five tumor markers (CAI9-9, CEA. NSE, SCC, TPA) were measured concomitantly in the serum of 128 patients with primary lung cancer (LC), 148 patients with benign disease (B) and 43 normal volunteers. The positive rates for all the twnor markers were significantly higher in tie LC group than in the B group. When multiple tumor markers were quantitated, the specificity for the detection of lung cancer became lower although the sensitivity increased. However, this
The diagnostic yield of bronchoscopy DierkesmannR.ZenrrumfurPneumologie undThoraxchirurgie, Klinik Schillerhohe. 7016 Gerlingen 2. Cardiovasc Inter-vent Radio1 1991;14:248. The endoscopic examination of the tracheobronchial tree 1s most helpful in the diagnosis and staging of bronchial carcinoma. Tumors that are endoscopically visible may he confumed in more than 95% of the cases. In localized peripheral tumors, the diagnostic yield of bmnchoscopy is significantly lower; for peripheral metastases, only about 10%. In diffuse interstitial pulmonary diseases other than malignancies, some infections,and histiocytosis X, bronchoscopy including trambronchial biopsy is less successful.
Collateral pathways observed by radionuclide superiorcavography in 70 patients with superior vena caval obstruction Muramatsu T, Miyamae T, Dohi Y. Second Departmenr of Internal Medicine, Saitanu Medical School, 38 Moroyama. IrWna-gUn, Saitoma, 350-04. Clin Nucl Med 1991;16:332-6. Schematic representations of collateral pathways that have developed in association with superior vena caval obstruction have been established in studies using radionuclide superior cavography (RNSC). However, these were hampered by the poor resolution of earlier scintillation cameras. Using a modern scintillation camera, we perfomxd RNSC in 7Opatients with obstruction of the superior venacaval system, and examined the differences in collateral pathways in the Presence or absence of obstruction of the azygos vein. RNSC visualized the site of obstruction and collateral pathways far more readily than in prior studies. When the orifice of the azygos vein was not obstructed,
Soluble interleukin-2 receptor and soluble CDS antigen levels in serum from patients with non-resectable lung cancer V&-Petersen J, Tvede N, Diamant M, Amt Kjerulff A, Rahbck Sorensen H, Andersen V. Sfeno Memorial Hospira/, 2 Nit/s Steensens Vej. DK-2820Genfofe. Cancer Immunol Immunother 1991;33:121-7. In a preliminary longitudinal study two women with histologically verilied adenocarcinoma of the lung, without simultaneous infectious or inflammatory conditions, were seen every 2 weeks until death. In one of the patients serum soluble interleukin-2 receptor (sIL-2R) levels rose progressively while the levels for the other patient increased during the second half of the observation period. Serum soluble CD8 antigen (sCD8 Ag) showed a pattern dissimilar to the one for sIL-2R. In a retrospective cross-sectional study circulating levels of sIL-2R and sCD8 Ag were measured before explorative thoracotomy in a total of 65 patients with histologically proven non-resectable carcinoma of the lung. The sIL-2R levels were significantly increased independently of histological subclassification while sCD8 Ag was increased only in patients with small-cell lung cancer. There was no correlation between pre-operative values and length of survival.
negativepointwasmade upfortosomeextentbyevaluating thenumber of positive markers. In monitoring the clinical course, independent changes were observed in markers in some cancer paoents. These results implied that measuring multiple tumor markers was of climcal value in monitoring the clinical course of cancer patients as well as in assisting the diagnosis of lung cancer.
Allatoxins in sera from patients with lung cancer Cusumano V. Microbiology Institute, Faculty of Medicine, Piazza XX Setfembre, I-98100 Messina. Oncology (Switzerland) 1991:48:194-5. Sera from patients with lung cancer and from healthy donors were screened for the presence of aflatoxins. Significant differencesin levels of aflatoxins between the two groups were found. Only 1 of the neoplastic patients with aflatoxins in the serum was a smoker. However the percentage of sera from lung cancer containmg aflatoxins 1s not significant enough to provide evidence for a casual relationship hetween aflatoxins exposure and development of lung cancer in humans.
Theprognmticsignificanceofpretreatmentserumlactatedehydrogenase in patients with small-cell lung cancer Sagman U, Feld R, Evans WK, Warr D, Shepherd FA, Payne D, et al. Ontario Cancer Institute. 500 Sherbourne Sr, Toronto. Onr. M4X IK9. J Clin Oncol 1991;9:954-61. Pretreatment serum lactate dehydrogenase (LDH) levels were assayed in 288 patients presenting with small-cell lung cancer (SCLC) between 1976 and 1985. Patients were routinely staged by physical examination,chestx-ray,bone,brain,andliverscans,andbonemarrow evaluation. Clinical response and survival were assessed following treatment with combination chemotherapy as part of four clinical trials. Patients with extensive disease (ED) presented with a higher incidence (108of 147.73%)ofabno~allyelevatedLDH(~ 193 IU/L.)thanthose (65 of 141.46%) with limiteddisease (P=2 x 104. Forty percent of patients had an initial normal LDH level and a higher response rate (89 of 108, 82%; complete response [CR], 47%) than those wth elevated values of LDH (1 I9 of 156, 76%: CR, 29%). ‘IIre CR rate varied inversely with the level of LDH in patients with LD (P= ,026) but not in those with ED (P = ,300). The median survival time and I-year and 2-year survival rates for patients with elevated LDH were 39 weeks and 33% and 6%. respectively, whereas for those with a normal LDH level these were 53 weeks and 54% and 16%. respectively. Patients with LD and elevated levels of LDH manifested a higher relative death rate (I .63: 1) when compared with patients with LD and LDH in the normal range (P = .0083). The survival of patients with ED did not differ between those with normal and elevated levels of LDH (P = ,273). A significant survival advantage persisted for patients with LDH in the normal range following adjustments for extent of disease, performance status (PS), and treatment protocol (P = ,044, log-rank analysis). In conclusion, serum LDH appears to be a significant independent pretreatment prognostic factor in patients with SCLC that correlates with stage of disease, response to treatment. and survival.
Computed tomography distinction of central thoracic masses Woodring JH, Johnson PI. Deparrmenr of Diagnostic Radiology, University of Kentucky Medical Center, 800 Rose Street, Lexington. KY 40536-0084. J Tborac Imaging 1991:6:32-9. In an analysis of 36 central lung, 54 mediastinal, and 10 central pleural masses, features were sought that would allow accurate localization of the mass by CT. The mass-lung interface was the most useful feature: with few exceptions a mass with a spiculated, nodular, or irregular edge was in (he lung, and a mass with a smooth edge was in the mediastinum. In the superior mediastinal, supraazygos, and supraaortic regions lung masses were lateral to the great vessels, and mediastinal masses were medial to the great vessels. Anterior mediastinal masses were typically positioned between the sternum and great vessels: some were more laterally positioned, however, and could only bc distinguished from lung masses by the mass-lung interface. In the infraazygas, infraaortic,andparaspinal areas, lungand mediastinal masses were best differentiated by the mass-lung interface. The angles formed between the mass and lung were occasionally helpful in localizing the mass. Central pleural masses were characterized by a lack of intimate mediastinal effect, obtuse angles between the mass and lung, a smooth mass-lung interface, and characteristic association with other similar areas of involvement in the pleural space. These criteria were used for thecorrectlocalizationof99of lOOmasses: therefore,theycansimplify and focus the work-up of most central thoracic masses. Clinical evaluation oftive tumor marker assay in patients with lung cancer Mizushima Y, Tsuji H, Izumi S, Hirata H, Kin Y, Kawasaki A, et al. lstDepanmentoflnterna1 Medicine. ToyamaMedicalandPharmaceurical (iniversity. Toyama 930-01, Anticancer Res 1991: 11:91-5. Five tumor markers (CAI9-9, CEA. NSE, SCC, TPA) were measured concomitantly in the serum of 128 patients with primary lung cancer (LC), 148 patients with benign disease (B) and 43 normal volunteers. The positive rates for all the twnor markers were significantly higher in tie LC group than in the B group. When multiple tumor markers were quantitated, the specificity for the detection of lung cancer became lower although the sensitivity increased. However, this
The diagnostic yield of bronchoscopy DierkesmannR.ZenrrumfurPneumologie undThoraxchirurgie, Klinik Schillerhohe. 7016 Gerlingen 2. Cardiovasc Inter-vent Radio1 1991;14:248. The endoscopic examination of the tracheobronchial tree 1s most helpful in the diagnosis and staging of bronchial carcinoma. Tumors that are endoscopically visible may he confumed in more than 95% of the cases. In localized peripheral tumors, the diagnostic yield of bmnchoscopy is significantly lower; for peripheral metastases, only about 10%. In diffuse interstitial pulmonary diseases other than malignancies, some infections,and histiocytosis X, bronchoscopy including trambronchial biopsy is less successful.
Collateral pathways observed by radionuclide superiorcavography in 70 patients with superior vena caval obstruction Muramatsu T, Miyamae T, Dohi Y. Second Departmenr of Internal Medicine, Saitanu Medical School, 38 Moroyama. IrWna-gUn, Saitoma, 350-04. Clin Nucl Med 1991;16:332-6. Schematic representations of collateral pathways that have developed in association with superior vena caval obstruction have been established in studies using radionuclide superior cavography (RNSC). However, these were hampered by the poor resolution of earlier scintillation cameras. Using a modern scintillation camera, we perfomxd RNSC in 7Opatients with obstruction of the superior venacaval system, and examined the differences in collateral pathways in the Presence or absence of obstruction of the azygos vein. RNSC visualized the site of obstruction and collateral pathways far more readily than in prior studies. When the orifice of the azygos vein was not obstructed,